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Tytuł:
Design, synthesis and biological evaluation of novel histone deacetylase (HDAC) inhibitors derived from β -elemene scaffold.
Autorzy:
Gao Y; Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines; Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, China.
Duan J; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines; Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, China.
Dang X; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines; Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, China.
Yuan Y; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines; Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, China.
Wang Y; Research and Development, Dalian HolleyKingkong Pharmaceutical Co. Ltd, Liaoning, China.
He X; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines; Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, China.
Bai R; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines; Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, China.
Ye XY; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines; Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, China.
Xie T; Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines; Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, China.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2023 Dec; Vol. 38 (1), pp. 2195991.
Typ publikacji:
Journal Article
MeSH Terms:
Histone Deacetylase Inhibitors*
Antineoplastic Agents*/chemistry
Animals ; Mice ; Cell Line, Tumor ; Cell Proliferation ; Histone Deacetylases/metabolism ; Drug Design ; Drug Screening Assays, Antitumor ; Histone Deacetylase 1/metabolism ; Histone Deacetylase 1/pharmacology ; Structure-Activity Relationship
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
High-content analysis identified synergistic drug interactions between INK128, an mTOR inhibitor, and HDAC inhibitors in a non-small cell lung cancer cell line.
Autorzy:
Wang S; School of Chemistry and Molecular Engineering at East China Normal University, Shanghai, 200062, China.
Oliveira-Silveira J; Center of Biotechnology, PPGBCM, Federal University of Rio Grande Do Sul (UFRGS), Porto Alegre, Rio Grande Do Sul, 91501970, Brazil.
Fang G; NYU-ECNU Center for Computational Chemistry at NYU Shanghai, Shanghai, 200062, China.; Arts and Science, New York University at Shanghai, Shanghai, 200122, China.
Kang J; NYU-ECNU Center for Computational Chemistry at NYU Shanghai, Shanghai, 200062, China. .; Arts and Science, New York University at Shanghai, Shanghai, 200122, China. .
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Źródło:
BMC cancer [BMC Cancer] 2024 Mar 12; Vol. 24 (1), pp. 335. Date of Electronic Publication: 2024 Mar 12.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Non-Small-Cell Lung*/drug therapy
Lung Neoplasms*/drug therapy
Antineoplastic Agents*/therapeutic use
Humans ; Histone Deacetylase Inhibitors/pharmacology ; MTOR Inhibitors ; Cell Line, Tumor ; Proteasome Inhibitors/therapeutic use ; Pyrimidines/therapeutic use ; TOR Serine-Threonine Kinases/metabolism ; Drug Combinations ; DNA/therapeutic use ; Drug Synergism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Discovery of novel polysubstituted N -alkyl acridone analogues as histone deacetylase isoform-selective inhibitors for cancer therapy.
Autorzy:
Wang Z; Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo, People's Republic of China.
Zhao L; Institute of Drug Discovery Technology, Ningbo University, Ningbo, People's Republic of China.
Zhang B; Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo, People's Republic of China.
Feng J; Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo, People's Republic of China.
Wang Y; Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo, People's Republic of China.
Zhang B; Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo, People's Republic of China.
Jin H; Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo, People's Republic of China.
Ding L; Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo, People's Republic of China.
Wang N; Institute of Drug Discovery Technology, Ningbo University, Ningbo, People's Republic of China.
He S; Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo, People's Republic of China.; Ningbo Institute of Marine Medicine, Peking University, Ningbo, People's Republic of China.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2023 Dec; Vol. 38 (1), pp. 2206581.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/chemistry
Neoplasms*
Humans ; Histone Deacetylase Inhibitors/pharmacology ; Histone Deacetylase Inhibitors/chemistry ; Molecular Structure ; Structure-Activity Relationship ; Cell Line, Tumor ; Molecular Docking Simulation ; Histone Deacetylases/metabolism ; Protein Isoforms/metabolism ; Cell Proliferation ; Histone Deacetylase 1/metabolism ; Histone Deacetylase 1/pharmacology ; Repressor Proteins/metabolism ; Repressor Proteins/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Synthesis and biological evaluation of C-4 substituted phenoxazine-bearing hydroxamic acids with potent class II histone deacetylase inhibitory activities.
Autorzy:
Chu JC; Ph.D. Program in Drug Discovery and Development Industry, College of Pharmacy, Taipei Medical University, Taipei, Taiwan.
Tseng HJ; School of Pharmacy, Taipei Medical University, Taipei, Taiwan.; Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California, United States.
Lee SB; Ph.D. Program in Drug Discovery and Development Industry, College of Pharmacy, Taipei Medical University, Taipei, Taiwan.
Hsu KC; Ph.D. Program in Drug Discovery and Development Industry, College of Pharmacy, Taipei Medical University, Taipei, Taiwan.; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.; Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.; TMU Research Center for Drug Discovery, Taipei Medical University, Taipei, Taiwan.
Hsin LW; School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan.
Liang RH; School of Pharmacy, Taipei Medical University, Taipei, Taiwan.
Lin TE; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.; Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.
Gao NC; Graduate Institute of Pharmacognosy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan.
Chen LC; Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California, United States.
Lu WH; Graduate Institute of Pharmacognosy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan.
Wang AH; The Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.
Huang WJ; Ph.D. Program in Drug Discovery and Development Industry, College of Pharmacy, Taipei Medical University, Taipei, Taiwan.; School of Pharmacy, Taipei Medical University, Taipei, Taiwan.; Graduate Institute of Pharmacognosy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2023 Dec; Vol. 38 (1), pp. 2212326.
Typ publikacji:
Journal Article
MeSH Terms:
Hydroxamic Acids*/pharmacology
Antineoplastic Agents*/pharmacology
Histone Deacetylase Inhibitors/pharmacology ; Hydrogen Peroxide/pharmacology ; Structure-Activity Relationship ; Histone Deacetylases/metabolism ; Histone Deacetylase 1/pharmacology ; Cell Proliferation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Discovery and biological evaluation of novel CARM1/HDAC2 dual-targeting inhibitors with anti-prostate cancer agents.
Autorzy:
Liang S; Department of Urology, Pharmacy and Oncology, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, China.
Geng Y; Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing, China.
Niu MM; Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing, China.
Zhang Y; Department of Urology, Pharmacy and Oncology, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, China.
He W; Department of Urology, Pharmacy and Oncology, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, China.
Li J; Department of Urology, Pharmacy and Oncology, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, China.
Yang L; Department of Urology, Pharmacy and Oncology, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, China.
Xu Z; Department of Urology, Pharmacy and Oncology, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, China.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2023 Dec; Vol. 38 (1), pp. 2241118.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*/pharmacology
Prostatic Neoplasms*/drug therapy
Prostatic Neoplasms*/metabolism
Male ; Humans ; Histone Deacetylase 2/metabolism ; Protein-Arginine N-Methyltransferases/metabolism ; Histone Deacetylase Inhibitors/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Sodium Butyrate Enhances the Cytotoxic Effect of Etoposide in HDACi-Sensitive and HDACi-Resistant Transformed Cells.
Autorzy:
Gnedina OO; Institute of Cytology, Russian Academy of Sciences, St. Petersburg 194064, Russia.
Morshneva AV; Institute of Cytology, Russian Academy of Sciences, St. Petersburg 194064, Russia.
Igotti MV; Institute of Cytology, Russian Academy of Sciences, St. Petersburg 194064, Russia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Nov 02; Vol. 24 (21). Date of Electronic Publication: 2023 Nov 02.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*/pharmacology
Butyric Acid/pharmacology ; bcl-2-Associated X Protein ; Etoposide/pharmacology ; Histone Deacetylase Inhibitors/pharmacology ; Apoptosis ; Cell Line, Tumor
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Epigenetic Modulators as Therapeutic Agents in Cancer.
Autorzy:
Patnaik E; Department of Biology, Memphis University School, Memphis, TN 38119, USA.
Madu C; Departments of Biological Sciences, University of Memphis, Memphis, TN 38152, USA.
Lu Y; Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Oct 06; Vol. 24 (19). Date of Electronic Publication: 2023 Oct 06.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Neoplasms*/drug therapy
Neoplasms*/genetics
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/therapeutic use
Humans ; Histones/metabolism ; DNA Methylation ; Epigenesis, Genetic ; Histone Deacetylase Inhibitors/pharmacology ; Histone Deacetylase Inhibitors/therapeutic use ; Acetylation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Identification of Novel Natural Dual HDAC and Hsp90 Inhibitors for Metastatic TNBC Using e-Pharmacophore Modeling, Molecular Docking, and Molecular Dynamics Studies.
Autorzy:
AbdElmoniem N; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Gezira, Wad Madani 21111, Sudan.
H Abdallah M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Gezira, Wad Madani 21111, Sudan.
M Mukhtar R; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Gezira, Wad Madani 21111, Sudan.
Moutasim F; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Gezira, Wad Madani 21111, Sudan.
Rafie Ahmed A; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Gezira, Wad Madani 21111, Sudan.
Edris A; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Gezira, Wad Madani 21111, Sudan.
Ibraheem W; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Gezira, Wad Madani 21111, Sudan.
Makki AA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Gezira, Wad Madani 21111, Sudan.
M Elshamly E; Department of Molecular Biotechnology, Hochschule Anhalt, 06846 Dessau-Roßlau, Germany.
Elhag R; Department of Biology, College of Science and Technology, Florida A & M University, Tallahassee, FL 32307, USA.
Osman W; Department of Pharmacognosy, Faculty of Pharmacy, University of Khartoum, Khartoum 11114, Sudan.
A Mothana R; Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Alzain AA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Gezira, Wad Madani 21111, Sudan.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Feb 13; Vol. 28 (4). Date of Electronic Publication: 2023 Feb 13.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*/pharmacology
Triple Negative Breast Neoplasms*/drug therapy
HSP90 Heat-Shock Proteins*/antagonists & inhibitors
Histone Deacetylase Inhibitors*/pharmacology
Female ; Humans ; Ligands ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Pharmacophore
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Design, Synthesis, and Antiproliferative Activity of Selective Histone Deacetylases 6 Inhibitors Containing a Tetrahydropyridopyrimidine Scaffold.
Autorzy:
Wang B; Department of Biochemistry and Molecular Biology, Sanquan College of Xinxiang Medical University, Xinxiang 453003, China.
Liu Y; Experimental Teaching Center of Biology & Basic Medicine, Sanquan College of Xinxiang Medical University, Xinxiang 453003, China.
Zhang L; Department of Biochemistry and Molecular Biology, Sanquan College of Xinxiang Medical University, Xinxiang 453003, China.
Wang Y; Department of Biochemistry and Molecular Biology, Sanquan College of Xinxiang Medical University, Xinxiang 453003, China.
Li Z; Department of Biochemistry and Molecular Biology, Sanquan College of Xinxiang Medical University, Xinxiang 453003, China.
Chen X; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Xianyang 712100, China.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Oct 29; Vol. 28 (21). Date of Electronic Publication: 2023 Oct 29.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*
Humans ; Histone Deacetylase 6 ; Cell Line, Tumor ; Histone Deacetylase Inhibitors ; HCT116 Cells ; Cell Proliferation ; Structure-Activity Relationship
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Phenylacetyl-/Trolox- Amides: Synthesis, Sigma-1, HDAC-6, and Antioxidant Activities.
Autorzy:
Flores R; Pharmaceutical Sciences Department, Feik School of Pharmacy, University of the Incarnate Word, San Antonio, TX 78209, USA.
Iqbal S; Pharmaceutical Sciences Department, Feik School of Pharmacy, University of the Incarnate Word, San Antonio, TX 78209, USA.
Sikazwe D; Pharmaceutical Sciences Department, Feik School of Pharmacy, University of the Incarnate Word, San Antonio, TX 78209, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Oct 18; Vol. 24 (20). Date of Electronic Publication: 2023 Oct 18.
Typ publikacji:
Journal Article
MeSH Terms:
Antioxidants*/pharmacology
Antineoplastic Agents*/pharmacology
Amides/pharmacology ; Chromans ; Structure-Activity Relationship ; Amines ; Histone Deacetylase Inhibitors/pharmacology ; Drug Design
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Discovery and SAR analysis of 5-chloro-4-((substituted phenyl)amino)pyrimidine bearing histone deacetylase inhibitors.
Autorzy:
Zhang L; Department of Medicinal Chemistry, School of Pharmacy, Weifang Medical University, Weifang, China.
Chen Y; School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.
Li F; Department of Medicinal Chemistry, School of Pharmacy, Weifang Medical University, Weifang, China.
Zhang L; School of Stomatology, Weifang Medical University, Weifang, China.
Feng J; Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of sciences), Jinan, China.
Zhang L; Department of Medicinal Chemistry, School of Pharmacy, Weifang Medical University, Weifang, China.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 1918-1927.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*/chemistry
Antineoplastic Agents*/pharmacology
Histone Deacetylase Inhibitors*/chemistry
Histone Deacetylase Inhibitors*/pharmacology
Apoptosis ; Cell Line, Tumor ; Cell Proliferation ; Histone Deacetylase 1 ; Histone Deacetylase 6/metabolism ; Histone Deacetylases/metabolism ; Pyrimidines/pharmacology ; Structure-Activity Relationship
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Solid-Phase Parallel Synthesis of Dual Histone Deacetylase-Cyclooxygenase Inhibitors.
Autorzy:
Bachmann LM; Institute for Drug Discovery, Medical Faculty, Leipzig University, Brüderstraße 34, 04103 Leipzig, Germany.
Hanl M; Department of Pharmaceutical and Cell Biological Chemistry, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany.
Feller F; Department of Pharmaceutical and Cell Biological Chemistry, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany.
Sinatra L; Institute for Drug Discovery, Medical Faculty, Leipzig University, Brüderstraße 34, 04103 Leipzig, Germany.
Schöler A; Institute for Drug Discovery, Medical Faculty, Leipzig University, Brüderstraße 34, 04103 Leipzig, Germany.
Pietzsch J; Department of Radiopharmaceutical and Chemical Biology, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Bautzner Landstraße 400, 01328 Dresden, Germany.; Faculty of Chemistry and Food Chemistry, School of Science, Technische Universität Dresden, Mommsenstraße 4, 01062 Dresden, Germany.
Laube M; Department of Radiopharmaceutical and Chemical Biology, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Bautzner Landstraße 400, 01328 Dresden, Germany.
Hansen FK; Department of Pharmaceutical and Cell Biological Chemistry, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Jan 20; Vol. 28 (3). Date of Electronic Publication: 2023 Jan 20.
Typ publikacji:
Journal Article
MeSH Terms:
Histone Deacetylase Inhibitors*/pharmacology
Antineoplastic Agents*/pharmacology
Cyclooxygenase 2 ; Cell Proliferation ; Histone Deacetylases ; Cyclooxygenase Inhibitors/pharmacology ; Cell Line, Tumor ; Drug Screening Assays, Antitumor
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Electrochemical Synthesis of New Isoxazoles and Triazoles Tethered with Thiouracil Base as Inhibitors of Histone Deacetylases in Human Breast Cancer Cells.
Autorzy:
Vishwanath D; Laboratory of Chemical Biology, Department of Studies in Organic Chemistry, University of Mysore, Mysore 570006, Karnataka, India.
Xi Z; Shenzhen Bay Laboratory, Shenzhen 518055, China.
Ravish A; Laboratory of Chemical Biology, Department of Studies in Organic Chemistry, University of Mysore, Mysore 570006, Karnataka, India.
Mohan A; Laboratory of Chemical Biology, Department of Studies in Organic Chemistry, University of Mysore, Mysore 570006, Karnataka, India.
Basappa S; Department of Chemistry, BITS-Pilani Hyderabad Campus, Jawaharnagar 500078, Medchal, Telangana, India.
Krishnamurthy NP; NMR Research Centre, Indian Institute of Science, Bangalore 560012, Karnataka, India.
Gaonkar SL; Department of Chemistry, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India.
Pandey V; Tsinghua Berkeley Shenzhen Institute, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China.; Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China.
Lobie PE; Shenzhen Bay Laboratory, Shenzhen 518055, China.; Tsinghua Berkeley Shenzhen Institute, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China.; Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China.
Basappa B; Laboratory of Chemical Biology, Department of Studies in Organic Chemistry, University of Mysore, Mysore 570006, Karnataka, India.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Jul 06; Vol. 28 (13). Date of Electronic Publication: 2023 Jul 06.
Typ publikacji:
Journal Article
MeSH Terms:
Breast Neoplasms*/drug therapy
Antineoplastic Agents*/chemistry
Humans ; Female ; Histone Deacetylases/metabolism ; Triazoles/chemistry ; Cell Line, Tumor ; Isoxazoles/pharmacology ; Histone Deacetylase Inhibitors/chemistry ; Cell Proliferation ; Structure-Activity Relationship
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Design, Synthesis, and Biological Evaluation of Novel Quinazolin-4(3H)-One-Based Histone Deacetylase 6 (HDAC6) Inhibitors for Anticancer Activity.
Autorzy:
Khetmalis YM; Department of Chemistry, Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Hyderabad 500078, Telangana, India.
Fathima A; Department of Biological Sciences, Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Hyderabad 500078, Telangana, India.
Schweipert M; Department of Chemical Engineering and Biotechnology, University of Applied Sciences Darmstadt, Haardtring 100, 64295 Darmstadt, Germany.
Debarnot C; Department of Chemical Engineering and Biotechnology, University of Applied Sciences Darmstadt, Haardtring 100, 64295 Darmstadt, Germany.
Bandaru NVMR; Department of Chemistry, Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Hyderabad 500078, Telangana, India.
Murugesan S; Medicinal Chemistry Research Laboratory, Department of Pharmacy, Birla Institute of Technology & Science Pilani, Pilani Campus, Pilani 333031, Rajasthan, India.
Jamma T; Department of Biological Sciences, Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Hyderabad 500078, Telangana, India.
Meyer-Almes FJ; Department of Chemical Engineering and Biotechnology, University of Applied Sciences Darmstadt, Haardtring 100, 64295 Darmstadt, Germany.
Sekhar KVGC; Department of Chemistry, Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Hyderabad 500078, Telangana, India.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jul 03; Vol. 24 (13). Date of Electronic Publication: 2023 Jul 03.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*/chemistry
Histone Deacetylase 6/metabolism ; Structure-Activity Relationship ; Cell Line, Tumor ; Quinazolines/pharmacology ; Quinazolines/chemistry ; Histone Deacetylase Inhibitors/chemistry ; Cell Proliferation ; Molecular Structure ; Histone Deacetylase 1/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Targeting HDAC6 to Overcome Autophagy-Promoted Anti-Cancer Drug Resistance.
Autorzy:
Jo H; Department of Biochemistry, College of Natural Sciences, Kangwon National University, Chuncheon 24341, Korea.
Shim K; Department of Biochemistry, College of Natural Sciences, Kangwon National University, Chuncheon 24341, Korea.
Jeoung D; Department of Biochemistry, College of Natural Sciences, Kangwon National University, Chuncheon 24341, Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Aug 24; Vol. 23 (17). Date of Electronic Publication: 2022 Aug 24.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Antineoplastic Agents*/pharmacology
Histone Deacetylase Inhibitors*/therapeutic use
Autophagy ; Histone Deacetylase 6 ; Histone Deacetylases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Histone Deacetylase Inhibitory Activity and Antiproliferative Potential of New [6]-Shogaol Derivatives.
Autorzy:
Phaosiri C; Natural Products Research Unit, Center of Excellence for Innovation in Chemistry, Ministry of Higher Education, Science, Research and Innovation (Implementation Unit-IU, Khon Kaen University), Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.
Yenjai C; Natural Products Research Unit, Center of Excellence for Innovation in Chemistry, Ministry of Higher Education, Science, Research and Innovation (Implementation Unit-IU, Khon Kaen University), Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.
Senawong T; Natural Products Research Unit, Department of Biochemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.
Senawong G; Natural Products Research Unit, Department of Biochemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.
Saenglee S; Ban Dong Sub-District Administration Organization, Ubolratana District, Khon Kaen 40250, Thailand.
Somsakeesit LO; Department of Chemistry, Faculty of Engineering, Rajamangala University of Technology Isan, Khon Kaen 40000, Thailand.
Kumboonma P; Department of Applied Chemistry, Faculty of Science and Liberal Arts, Rajamangala University of Technology Isan, Nakhon Ratchasima 30000, Thailand.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2022 May 22; Vol. 27 (10). Date of Electronic Publication: 2022 May 22.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*/pharmacology
Histone Deacetylase Inhibitors*/pharmacology
Histone Deacetylases*/metabolism
Catechols ; Cell Line, Tumor ; Cell Proliferation ; Humans ; Molecular Docking Simulation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Target Design of Novel Histone Deacetylase 6 Selective Inhibitors with 2-Mercaptoquinazolinone as the Cap Moiety.
Autorzy:
Bui HTB; Department of Chemistry, College of Natural Sciences, Can Tho University, Can Tho 900000, Vietnam.
Nguyen PH; Department of Biomedical Science, BK21 FOUR Program in Biomedical Science and Engineering, Inha University College of Medicine, Incheon 22212, Korea.; Inha Institute of Aerospace Medicine, Inha University College of Medicine, Incheon 22332, Korea.
Pham QM; Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, Ha Noi 100000, Vietnam.; Faculty of Chemistry; Vietnam Academy of Science and Technology, Graduate University of Science and Technology, Ha Noi 100000, Vietnam.
Tran HP; Department of Biomedical Science, BK21 FOUR Program in Biomedical Science and Engineering, Inha University College of Medicine, Incheon 22212, Korea.; Inha Institute of Aerospace Medicine, Inha University College of Medicine, Incheon 22332, Korea.
Tran Q; Department of Chemistry, College of Natural Sciences, Can Tho University, Can Tho 900000, Vietnam.
Jung H; Department of Biomedical Science, BK21 FOUR Program in Biomedical Science and Engineering, Inha University College of Medicine, Incheon 22212, Korea.; Inha Institute of Aerospace Medicine, Inha University College of Medicine, Incheon 22332, Korea.
Hong QV; Department of Chemistry, College of Natural Sciences, Can Tho University, Can Tho 900000, Vietnam.
Nguyen QC; Department of Chemistry, College of Natural Sciences, Can Tho University, Can Tho 900000, Vietnam.
Nguyen QP; Department of Chemistry, College of Natural Sciences, Can Tho University, Can Tho 900000, Vietnam.
Le HT; Department of Chemistry, College of Natural Sciences, Can Tho University, Can Tho 900000, Vietnam.
Yang SG; Department of Biomedical Science, BK21 FOUR Program in Biomedical Science and Engineering, Inha University College of Medicine, Incheon 22212, Korea.; Inha Institute of Aerospace Medicine, Inha University College of Medicine, Incheon 22332, Korea.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2022 Mar 28; Vol. 27 (7). Date of Electronic Publication: 2022 Mar 28.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*/chemistry
Antineoplastic Agents*/pharmacology
Histone Deacetylase Inhibitors*/chemistry
Histone Deacetylase Inhibitors*/pharmacology
Cell Proliferation ; Drug Screening Assays, Antitumor ; Epigenesis, Genetic ; Histone Deacetylase 6 ; Histone Deacetylases/metabolism ; Humans ; Molecular Docking Simulation ; Molecular Structure ; Repressor Proteins/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Synergistic Interaction of the Class IIa HDAC Inhibitor CHDI0039 with Bortezomib in Head and Neck Cancer Cells.
Autorzy:
Schrenk C; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany.
Bollmann LM; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany.
Haist C; Department of Otorhinolaryngology, Head & Neck Surgery, Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany.
Bister A; Department of Otorhinolaryngology, Head & Neck Surgery, Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany.
Wiek C; Department of Otorhinolaryngology, Head & Neck Surgery, Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany.
Wecker M; Department of General, Visceral and Pediatric Surgery, Medical Faculty, University Hospital of the Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany.
Roth D; Department of General, Visceral and Pediatric Surgery, Medical Faculty, University Hospital of the Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany.
Petzsch P; Biological and Medical Research Centre (BMFZ), Genomics & Transcriptomics Laboratory, Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany.
Köhrer K; Biological and Medical Research Centre (BMFZ), Genomics & Transcriptomics Laboratory, Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany.
Hamacher A; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany.
Hanenberg H; Department of Otorhinolaryngology, Head & Neck Surgery, Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany.; Department of Pediatrics III, University Children's Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.
Fluegen G; Department of General, Visceral and Pediatric Surgery, Medical Faculty, University Hospital of the Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany.
Kassack MU; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Mar 14; Vol. 24 (6). Date of Electronic Publication: 2023 Mar 14.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*/pharmacology
Head and Neck Neoplasms*/drug therapy
Head and Neck Neoplasms*/genetics
Humans ; Histone Deacetylase Inhibitors/pharmacology ; Bortezomib/pharmacology ; Cisplatin ; Squamous Cell Carcinoma of Head and Neck/drug therapy ; Squamous Cell Carcinoma of Head and Neck/genetics ; Cell Line, Tumor
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Entinostat-Bortezomib Hybrids against Multiple Myeloma.
Autorzy:
Ferro A; School of Pharmaceutical Sciences, University of Geneva, 1211 Geneva, Switzerland.; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, 1211 Geneva, Switzerland.
Graikioti D; Synthetic Organic Chemistry Laboratory, Department of Chemistry, University of Patras, 26504 Patras, Greece.
Gezer E; School of Pharmaceutical Sciences, University of Geneva, 1211 Geneva, Switzerland.; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, 1211 Geneva, Switzerland.
Athanassopoulos CM; Synthetic Organic Chemistry Laboratory, Department of Chemistry, University of Patras, 26504 Patras, Greece.
Cuendet M; School of Pharmaceutical Sciences, University of Geneva, 1211 Geneva, Switzerland.; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, 1211 Geneva, Switzerland.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Feb 02; Vol. 28 (3). Date of Electronic Publication: 2023 Feb 02.
Typ publikacji:
Journal Article
MeSH Terms:
Multiple Myeloma*/drug therapy
Multiple Myeloma*/metabolism
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/therapeutic use
Humans ; Bortezomib/pharmacology ; Bortezomib/therapeutic use ; Proteasome Endopeptidase Complex/metabolism ; Boronic Acids/pharmacology ; Cell Line, Tumor ; Neoplasm Recurrence, Local/drug therapy ; Proteasome Inhibitors/pharmacology ; Proteasome Inhibitors/therapeutic use ; Histone Deacetylase Inhibitors/therapeutic use ; Histone Deacetylases ; Drug Resistance, Neoplasm
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Mitigating the BFL1-mediated antiapoptotic pathway in diffuse large B cell lymphoma by inhibiting HDACs.
Autorzy:
Park E; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.; Center for Medical Innovation, Seoul National University Hospital, Seoul, Republic of Korea.
Lee C; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.; Center for Medical Innovation, Seoul National University Hospital, Seoul, Republic of Korea.
Park J; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.; Center for Medical Innovation, Seoul National University Hospital, Seoul, Republic of Korea.
Liu J; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.; Center for Medical Innovation, Seoul National University Hospital, Seoul, Republic of Korea.
Hong J; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.; Center for Medical Innovation, Seoul National University Hospital, Seoul, Republic of Korea.; Department of Internal Medicine, Division of Hematology and Medical Oncology, Seoul National University Hospital, Seoul, Republic of Korea.
Shin DY; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.; Center for Medical Innovation, Seoul National University Hospital, Seoul, Republic of Korea.; Department of Internal Medicine, Division of Hematology and Medical Oncology, Seoul National University Hospital, Seoul, Republic of Korea.
Byun JM; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.; Center for Medical Innovation, Seoul National University Hospital, Seoul, Republic of Korea.; Department of Internal Medicine, Division of Hematology and Medical Oncology, Seoul National University Hospital, Seoul, Republic of Korea.
Yun H; Center for Medical Innovation, Seoul National University Hospital, Seoul, Republic of Korea.; Department of Internal Medicine, Division of Hematology and Medical Oncology, Seoul National University Hospital, Seoul, Republic of Korea.; Center for Precision Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Koh Y; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.; Center for Medical Innovation, Seoul National University Hospital, Seoul, Republic of Korea.; Department of Internal Medicine, Division of Hematology and Medical Oncology, Seoul National University Hospital, Seoul, Republic of Korea.
Yoon SS; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.; Center for Medical Innovation, Seoul National University Hospital, Seoul, Republic of Korea.; Department of Internal Medicine, Division of Hematology and Medical Oncology, Seoul National University Hospital, Seoul, Republic of Korea.
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Źródło:
Leukemia & lymphoma [Leuk Lymphoma] 2023 Jan; Vol. 64 (1), pp. 205-216. Date of Electronic Publication: 2022 Nov 04.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Agents*/therapeutic use
Lymphoma, Large B-Cell, Diffuse*/drug therapy
Lymphoma, Large B-Cell, Diffuse*/genetics
Lymphoma, Large B-Cell, Diffuse*/metabolism
Humans ; Histone Deacetylase Inhibitors/pharmacology ; Histone Deacetylase Inhibitors/therapeutic use ; Cell Line, Tumor ; Histone Deacetylases/genetics ; Histone Deacetylases/metabolism ; Apoptosis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
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