Temat: "Histone Deacetylases metabolism" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Proinflammatory Cytokines Perturb Mouse and Human Pancreatic Islet Circadian Rhythmicity and Induce Uncoordinated β-Cell Clock Gene Expression via Nitric Oxide, Lysine Deacetylases, and Immunoproteasomal Activity
Autorzy:: Nico Fischer
Peter Horskjær Rose
Tina Dahlby
Charna Dibner
Phillip Alexander Keller Andersen
Seyed Mojtaba Ghiasi
Melissa Koomen
Thomas Mandrup-Poulsen
Volodymyr Petrenko; Pokaż więcej
Temat:: chronobiology
diabetes
epigenetics
immuno-metabolism
nitric oxide synthase
Inorganic Chemistry
Organic Chemistry
Physical and Theoretical Chemistry
Computer Science Applications
Spectroscopy
Molecular Biology
General Medicine
Catalysis
CLOCK
HDAC3
Cell biology
Pancreatic islets
medicine.anatomical_structure
medicine
PER2
Proinflammatory cytokine
Chemistry
Knockout mouse
Viability assay
Nitric oxide synthase
biology.protein
biology
Nitric oxide
chemistry.chemical_compound
Cell
Islet
geography.geographical_feature_category
geography
Circadian rhythm
Epigenetics
Article
ddc:612
ddc:616
ARNTL Transcription Factors/genetics/metabolism
Animals
Cell Line
Tumor
Cells
Cultured
Circadian Rhythm
Female
HEK293 Cells
Histone Deacetylases/metabolism
Humans
Insulin/metabolism
Insulin-Secreting Cells/drug effects/metabolism
Interferon-gamma/metabolism/pharmacology
Male
Mice
Nitric Oxide/metabolism
Proteasome Endopeptidase Complex/metabolism
Reactive Oxygen Species/metabolism
lcsh:Biology (General)
lcsh:QH301-705.5
lcsh:Chemistry
lcsh:QD1-999
biochemistry
Źródło:: International Journal of Molecular Sciences
Volume 22
Issue 1
International Journal of Molecular Sciences, Vol. 22, No 1 (2020) P. 83
International Journal of Molecular Sciences, Vol 22, Iss 83, p 83 (2021)
Opis pliku:: application/pdf
Dostępność:: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57f713196105e260c2898cb08ff9e574

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Skocz do pozycji: 2.

Tytuł:: A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing
Autorzy:: Simoben, Conrad
Robaa, Dina
Chakrabarti, Alokta
Schmidtkunz, Karin
Marek, Martin
Lancelot, Julien
Kannan, Srinivasaraghavan
Melesina, Jelena
Shaik, Tajith
Pierce, Raymond
Romier, Christophe
Jung, Manfred
Sippl, Wolfgang; Pokaż więcej
Temat:: crystal structure
docking
epigenetics
histone deacetylase (HDAC) inhibitors
schistosomiasis
virtual screening
MESH: Animals
MESH: Anthelmintics/pharmacology
MESH: Hydroxamic Acids/chemical synthesis
MESH: Hydroxamic Acids/pharmacology
MESH: Apoptosis/drug effects
MESH: Molecular Docking Simulation
MESH: Protein Binding
MESH: Protein Interaction Domains and Motifs
MESH: Protein Structure, Secondary
MESH: Pyrrolidines/chemical synthesis
MESH: Pyrrolidines/pharmacology
MESH: Schistosoma mansoni/drug effects
MESH: Helminth Proteins/chemistry
MESH: Schistosoma mansoni/enzymology
MESH: Schistosoma mansoni/genetics
MESH: Schistosoma mansoni/growth & development
MESH: Binding Sites
MESH: Structure-Activity Relationship
MESH: Zinc/chemistry
MESH: Zinc/metabolism
MESH: Chelating Agents/chemical synthesis
MESH: Anthelmintics/chemical synthesis
MESH: Chelating Agents/pharmacology
MESH: Helminth Proteins/genetics
MESH: Crystallography, X-Ray
MESH: Gene Expression
MESH: Helminth Proteins/antagonists & inhibitors
MESH: Helminth Proteins/metabolism
MESH: Histone Deacetylase Inhibitors/chemical synthesis
MESH: Histone Deacetylase Inhibitors/pharmacology
MESH: Histone Deacetylases/chemistry
MESH: Histone Deacetylases/genetics
MESH: Histone Deacetylases/metabolism
[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM]
lcsh:Organic chemistry
lcsh:QD241-441
Animals
Anthelmintics/pharmacology
Hydroxamic Acids/chemical synthesis
Hydroxamic Acids/pharmacology
Apoptosis/drug effects
Molecular Docking Simulation
Protein Binding
Protein Interaction Domains and Motifs
Protein Structure, Secondary
Pyrrolidines/chemical synthesis
Pyrrolidines/pharmacology
Schistosoma mansoni/drug effects
Helminth Proteins/chemistry
Schistosoma mansoni/enzymology
Schistosoma mansoni/genetics
Schistosoma mansoni/growth & development
Binding Sites
Structure-Activity Relationship
Zinc/chemistry
Zinc/metabolism
Chelating Agents/chemical synthesis
Anthelmintics/chemical synthesis
Chelating Agents/pharmacology
Helminth Proteins/genetics
Crystallography, X-Ray
Gene Expression
Helminth Proteins/antagonists & inhibitors
Helminth Proteins/metabolism
Histone Deacetylase Inhibitors/chemical synthesis
Histone Deacetylase Inhibitors/pharmacology
Histone Deacetylases/chemistry
Histone Deacetylases/genetics
Histone Deacetylases/metabolism
Chemistry (miscellaneous)
Analytical Chemistry
Organic Chemistry
Physical and Theoretical Chemistry
Molecular Medicine
Drug Discovery
Pharmaceutical Science
Structure–activity relationship
Schistosoma mansoni
biology.organism_classification
biology
Virtual screening
Epigenome
Biochemistry
Chemistry
HDAC8
In silico
Docking (dog)
Article
Źródło:: Molecules
Molecules, MDPI, 2018, 23 (3), pp.566. ⟨10.3390/molecules23030566⟩
Molecules, Vol 23, Iss 3, p 566 (2018)
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Opis pliku:: application/octet-stream
Dostępność:: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c57756972e5c4439f4e393638be3994b
https://hal.archives-ouvertes.fr/hal-02391176

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Szczegóły

Skocz do pozycji: 3.

Tytuł:: POWERDRESS-mediated histone deacetylation is essential for thermomorphogenesis in Arabidopsis thaliana
Autorzy:: David J. Tremethick
Avilash Singh Yadav
Celine Tasset
Sureshkumar Balasubramanian
Lennard van der Woude
Maxim Nekrasov
Sridevi Sureshkumar
Martijn van Zanten
Rupali Singh; Pokaż więcej
Temat:: Acetylation
Arabidopsis/genetics
Arabidopsis Proteins/genetics
Histone Deacetylases/metabolism
Histones/metabolism
Morphogenesis
Mutation
Temperature
Transcription Factors/genetics
Research Article
Biology and life sciences
Biochemistry
Proteins
DNA-binding proteins
Histones
Genetics
Gene Expression
Gene Regulation
Plant Science
Plant Anatomy
Fruit and Seed Anatomy
Plant Embryo Anatomy
Hypocotyl
Developmental Biology
Embryogenesis
Plant Embryogenesis
Plant Growth and Development
Plant Development
Computational Biology
Genome Analysis
Transcriptome Analysis
Genomics
Cell Biology
Chromosome Biology
Chromatin
Nucleosomes
Epigenetics
Research and Analysis Methods
Experimental Organism Systems
Model Organisms
Arabidopsis Thaliana
Organisms
Eukaryota
Plants
Brassica
Plant and Algal Models
Cancer Research
Genetics(clinical)
Molecular Biology
Ecology, Evolution, Behavior and Systematics
Chromatin remodeling
Histone
biology.protein
biology
Arabidopsis thaliana
biology.organism_classification
Nucleosome
HDAC9
Regulation of gene expression
Cell biology
SAP30
Histone H1
Histone H2A
Histone methylation
Histone code
Histone methyltransferase
lcsh:Genetics
lcsh:QH426-470
food and beverages
Źródło:: PLoS Genetics
PLoS Genetics, 14(3)
PLoS Genetics, Vol 14, Iss 3, p e1007280 (2018)
Opis pliku:: image/pdf
Dostępność:: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d57a60975b88b4bf219bb7925e75a4bb

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Szczegóły

Skocz do pozycji: 4.

Tytuł:: The crystal structure of the Leishmania infantum Silent Information Regulator 2 related protein 1: Implications to protein function and drug design
Autorzy:: Ronin, Céline
Costa, David Mendes
Tavares, Joana
Faria, Joana
Ciesielski, Fabrice
Ciapetti, Paola
Smith, Terry K.
MacDougall, Jane
Cordeiro-da-Silva, Anabela
Pemberton, Iain K.; Pokaż więcej
Temat:: Binding Site
Crystallography, X-Ray
Drug Design
Group III Histone Deacetylases / chemistry
Group III Histone Deacetylases / metabolism
Humans
Leishmania infantum / metabolismo
Models, Molecular
Peptides / metabolism
Protein Binding
Protein Structure, Secondary
Protozoan Proteins / chemistry
Protozoan Proteins / metabolism
lcsh:Medicine
lcsh:R
lcsh:Science
lcsh:Q
QH301 Biology
RM Therapeutics. Pharmacology
DAS
QH301
RM
Multidisciplinary
Amino acid
chemistry.chemical_classification
chemistry
SIRT2
Function (biology)
Protein structure
Cofactor binding
Cell biology
Sirtuin
biology.protein
biology
Acetylation
Leishmania infantum
biology.organism_classification
Research Article
Physical Sciences
Physics
Condensed Matter Physics
Solid State Physics
Crystallography
Crystal Structure
Biology and Life Sciences
Molecular Biology
Molecular Biology Techniques
Mutagenesis and Gene Deletion Techniques
Deletion Mutagenesis
Research and Analysis Methods
Biochemistry
Enzymology
Enzymes
Proteases
Serine Proteases
Proteins
Macromolecular Structure Analysis
Protein Structure
Recombinant Proteins
Microbiology
Protozoology
Kinetoplastids
Developmental Biology
Life Cycles
Protozoan Life Cycles
Promastigotes
Chemistry
Chemical Compounds
Organic Compounds
Amino Acids
Hydroxyl Amino Acids
Serine
Organic Chemistry
Źródło:: PLoS ONE, Vol 13, Iss 3, p e0193602 (2018)
PLoS ONE
Opis pliku:: application/pdf
Dostępność:: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88cfc4b29d9187320b8ad4cb262ede39

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Szczegóły

Skocz do pozycji: 5.

Tytuł:: HDAC3 is a molecular brake of the metabolic switch supporting white adipose tissue browning
Autorzy:: Ferrari, Alessandra
Longo, Raffaella
Fiorino, Erika
Silva, Rui
Mitro, Nico
Cermenati, Gaia
Gilardi, Federica
Desvergne, Béatrice
Andolfo, Annapaola
Magagnotti, Cinzia
Caruso, Donatella
Fabiani, Emma De
Hiebert, Scott W.
Crestani, Maurizio; Pokaż więcej
Temat:: Article
Adipocytes/physiology
Adipose Tissue, Brown/physiology
Adipose Tissue, White/physiology
Animals
Cell Line
Diet, High-Fat
Gene Expression Regulation/physiology
Gene Silencing
Histone Deacetylases/genetics
Histone Deacetylases/metabolism
Lipid Metabolism
Male
Mice
Mice, Knockout
lcsh:Science
lcsh:Q
General Physics and Astronomy
General Biochemistry, Genetics and Molecular Biology
General Chemistry
White adipose tissue
Futile cycle
Fatty acid metabolism
chemistry.chemical_compound
chemistry
HDAC3
Lipid metabolism
Adipose tissue
Biology
Biochemistry
Fatty acid synthesis
PPARA Gene
adipocytes
adipose tissue, brown
adipose tissue, white
animals
cell line
diet, high-fat
gene expression regulation
gene silencing
histone deacetylases
lipid metabolism
male
mice
mice, knockout
chemistry (all)
biochemistry, genetics and molecular biology (all)
Settore BIO/10 - Biochimica
food and beverages
nutritional and metabolic diseases
hormones, hormone substitutes, and hormone antagonists
lipids (amino acids, peptides, and proteins)
Źródło:: Nature Communications
Nature Communications, vol. 8, no. 1, pp. 93
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Opis pliku:: application/pdf
Dostępność:: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c512383fec48820206bfc3269b78fc0b
http://europepmc.org/articles/PMC5522415

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Szczegóły

Skocz do pozycji: 6.

Tytuł:: UHPLC-MS-based HDAC Assay Applied to Bio-guided Microfractionation of Fungal Extracts
Autorzy:: Pierre-Marie Allard
Jean-Luc Wolfender
Muriel Cuendet
Katia Gindro
Claudia Simões-Pires
Laurence Marcourt
Lucie Ory
Vincent Zwick; Pokaż więcej
Temat:: ddc:615
Chromatography
High Pressure Liquid/methods
Fungi/metabolism
Histone Deacetylases/metabolism
Tandem Mass Spectrometry/methods
Complementary and alternative medicine
Drug Discovery
Plant Science
Molecular Medicine
General Medicine
Biochemistry
Food Science
Analytical Chemistry
Chemistry
Panobinostat
chemistry.chemical_compound
Penicillium griseofulvum
Vorinostat
medicine.drug
medicine
Pharmacology
Trypsin
Belinostat
Histone deacetylase
Enzyme assay
biology.protein
biology
Romidepsin
Źródło:: Phytochemical Analysis, Vol. 28, No 2 (2017) pp. 93-100
Dostępność:: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02b2a031951c1cb9a72525fb8c2df044
https://archive-ouverte.unige.ch/unige:94971

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Szczegóły

Skocz do pozycji: 7.

Tytuł:: Biphenyl-4-yl-acrylohydroxamic acids: identification of a novel indolyl-substituted HDAC inhibitor with antitumor activity
Autorzy:: Cincinelli, Raffaella
Zwick, Vincent
Musso, Loana
Zuco, Valentina
De Cesare, Michelandrea
Zunino, Franco
Simoes-Pires, Claudia
Nurisso, Alessandra
Giannini, Giuseppe
Cuendet, Muriel
Dallavalle, Sabrina; Pokaż więcej
Temat:: Hydroxamic acids
HDAC inhibitors
Antiproliferative activity
Antitumor activity
Synthesis
Settore CHIM/08 - Chimica Farmaceutica
Settore CHIM/06 - Chimica Organica
Organic Chemistry
Drug Discovery
Pharmacology
General Medicine
Docking (molecular)
Biochemistry
Structure–activity relationship
In vitro
Active site
biology.protein
biology
Acetylation
Chemistry
In vivo
Biphenyl compound
Histone H4
Stereochemistry
ddc:615
Antineoplastic Agents/chemistry/pharmacology
Apoptosis/drug effects
Biphenyl Compounds/chemistry/pharmacology
Colonic Neoplasms/drug therapy/metabolism
Drug Screening Assays
Antitumor
HCT116 Cells
Histone Deacetylase Inhibitors/chemistry/pharmacology
Histone Deacetylases/metabolism
Humans
Hydroxamic Acids/chemistry/pharmacology
Molecular Docking Simulation
Neoplasms/drug therapy/metabolism
Structure-Activity Relationship
Źródło:: European Journal of Medicinal Chemistry, Vol. 112 (2016) pp. 99-105
Dostępność:: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c41240a5dcd709036f451727b80a3b2
http://hdl.handle.net/2434/420166

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Szczegóły

Skocz do pozycji: 8.

Tytuł:: The fusion protein SS18-SSX1 employs core Wnt pathway transcription factors to induce a partial Wnt signature in synovial sarcoma
Autorzy:: Cironi, Luisa
Petricevic, Tanja
Fernandes Vieira, Victor
Provero, Paolo
Fusco, Carlo
Cornaz, Sandrine
Fregni, Giulia
Letovanec, Igor
Aguet, Michel
Stamenkovic, Ivan; Pokaż więcej
Temat:: Multidisciplinary
AXIN2
LRP5
Wnt signaling pathway
Fusion protein
TCF/LEF family
Cancer research
LRP6
Beta-catenin
biology.protein
biology
Transcription factor
Animals
Axin Protein
Blotting, Western
Cell Line
Cell Line, Tumor
Gene Expression Profiling
Histone Deacetylases
Humans
Mice
Microscopy, Confocal
Oncogene Proteins, Fusion
RNA Interference
Repressor Proteins
Reverse Transcriptase Polymerase Chain Reaction
Sarcoma, Synovial
TCF Transcription Factors
Transcription Factors
Wnt Signaling Pathway
beta Catenin
Axin Protein/genetics
Axin Protein/metabolism
Gene Expression Profiling/methods
Histone Deacetylases/genetics
Histone Deacetylases/metabolism
Oncogene Proteins, Fusion/genetics
Oncogene Proteins, Fusion/metabolism
Repressor Proteins/genetics
Repressor Proteins/metabolism
Sarcoma, Synovial/genetics
Sarcoma, Synovial/metabolism
Sarcoma, Synovial/pathology
TCF Transcription Factors/genetics
TCF Transcription Factors/metabolism
Transcription Factors/genetics
Transcription Factors/metabolism
Wnt Signaling Pathway/genetics
beta Catenin/genetics
beta Catenin/metabolism
Article
Źródło:: Scientific reports, vol. 6, pp. 22113
Scientific Reports
Opis pliku:: application/pdf
Dostępność:: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60efadcc1928d9d1f484ba21cc89d788

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Pełny tekst Szczegóły

Skocz do pozycji: 9.

Tytuł:: Cell-based multi-substrate assay coupled to UHPLC-ESI-MS/MS for a quick identification of class-specific HDAC inhibitors
Autorzy:: Zwick, Vincent
Simoes Avello, Claudia
Cuendet, Muriel; Pokaż więcej
Temat:: Biochemistry
Genetics
FOS: Biological sciences
Molecular Biology
Pharmacology
Biotechnology
39999 Chemical Sciences not elsewhere classified
FOS: Chemical sciences
Cancer
110309 Infectious Diseases
FOS: Health sciences
60506 Virology
Drug Discovery
General Medicine
HDAC6
medicine.disease
medicine
Biology
High-throughput screening
Histone
biology.protein
Cell
medicine.anatomical_structure
Histone deacetylase
Enzyme
chemistry.chemical_classification
chemistry
Drug discovery
ddc:615
Chromatography
High Pressure Liquid
Dose-Response Relationship
Drug
Drug Evaluation
Preclinical/methods
HeLa Cells
Histone Deacetylase 1/antagonists & inhibitors/metabolism
Histone Deacetylase Inhibitors/analysis/chemistry/pharmacology
Histone Deacetylases/metabolism
Humans
Molecular Conformation
Spectrometry
Mass
Electrospray Ionization
Structure-Activity Relationship
Źródło:: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol. 31, No sup1 (2016) pp. 209-214
Dostępność:: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::883ab462cbcd9a7751ca36c6ff377bbe

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Skocz do pozycji: 10.

Tytuł:: Cross metathesis with hydroxamate and benzamide BOC-protected alkenes to access HDAC inhibitors and their biological evaluation highlighted intrinsic activity of BOC-protected dihydroxamates
Autorzy:: Alessandra Nurisso
Claudia Simões-Pires
Philippe Bertrand
Attila Lehotzky
Samuel Bouchet
Nadine Martinet
Muriel Cuendet
Vincent Zwick
Judit Ovádi
Christophe Blanquart; Pokaż więcej
Temat:: [SDV.CAN]Life Sciences [q-bio]/Cancer
ddc:615
Alkenes/chemistry
Benzamides/chemistry
Dose-Response Relationship
Drug
Formic Acid Esters/chemistry
Histone Deacetylase Inhibitors/chemistry/pharmacology
Histone Deacetylases/metabolism
Humans
Hydroxamic Acids/chemistry
Models
Molecular
Molecular Structure
Structure-Activity Relationship
Organic Chemistry
Clinical Biochemistry
Drug Discovery
Pharmaceutical Science
Molecular Biology
Molecular Medicine
Biochemistry
Selectivity
Structure–activity relationship
Stereochemistry
Convergent synthesis
Benzamide
chemistry.chemical_compound
chemistry
Intrinsic activity
Catalysis
Tubulin
biology.protein
biology
Metathesis
Źródło:: Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2016, ⟨10.1016/j.bmcl.2015.11.011⟩
Bioorganic & Medicinal Chemistry Letters, Vol. 26, No 1 (2016) pp. 154-159
Dostępność:: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acc9fefa73c13b45a09cef22d951db0c
https://www.hal.inserm.fr/inserm-01299475

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Szczegóły

Skocz do pozycji: 11.

Tytuł:: ‘Relax and Repair’ to restrain aging
Autorzy:: Zhongjun Zhou
Baohua Liu
Krishnan; Pokaż więcej
Temat:: Cell Biology
Ageing
DNA mismatch repair
Histone H4
DNA repair
Chromatin
Histone
biology.protein
biology
Premature aging
Genetics
Chromatin remodeling
Cell biology
Histone code
Dna Repair
Lamin A
Prelamin A
Premature Aging
Zmpste24
Senescence
Histone Acetylation
Hgps
Epigenetics
Progeria - genetics - physiopathology
Mice
Lamin Type A - chemistry - genetics - metabolism
Humans
Histones - metabolism
Histone Deacetylases - metabolism
Epigenesis, Genetic
Chromatin - chemistry - metabolism
Animals
Protein Precursors - chemistry - genetics - metabolism
Nuclear Proteins - chemistry - genetics - metabolism
DNA Damage
Aging - genetics
Research Perspective
Źródło:: Aging (Albany NY)
Dostępność:: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c47b742530234e85caa09b5d3770e13
https://www.aging-us.com/lookup/doi/10.18632/aging.100399

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Szczegóły

Skocz do pozycji: 12.

Tytuł:: Insulin-dependent transcriptional control in L6 rat myotubes is associated with modulation of histone acetylation and accumulation of the histone variant H2A.Z in the proximity of the transcriptional start site
Autorzy:: Team1 Carmen
Hubert VIDAL
Team2 Carmen
Luciano Pirola
Carmen Lab; Pokaż więcej
Temat:: Humans
Animals
Rats
Acetylation
Gene Expression Regulation
Transcription Initiation Site
Class Ia Phosphatidylinositol 3-Kinase/metabolism
Hexokinase/metabolism
Histone Deacetylases/metabolism
Histones/*metabolism
Insulin Receptor Substrate Proteins/metabolism
Insulin/*metabolism/pharmacology
Muscle Fibers
Skeletal/drug effects/*metabolism
Phosphatidylinositol 3-Kinases/metabolism
Promoter Regions
Genetic
[SDV]Life Sciences [q-bio]
Cell Biology
Molecular Biology
Biochemistry
Histone deacetylase 2
Histone H2A
Histone deacetylase inhibitor
medicine.drug_class
medicine
Histone code
Biology
Molecular biology
SAP30
Histone deacetylase
Histone H1
HDAC4
Źródło:: Biochemistry and Cell Biology
Biochemistry and Cell Biology, NRC Research Press, 2014, 92 (1), pp.61-7. ⟨10.1139/bcb-2013-0071⟩
Dostępność:: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::313ee74892e18d034649a649e0cef462
https://hal.archives-ouvertes.fr/hal-01859362

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Szczegóły

Skocz do pozycji: 13.

Tytuł:: Activation of histone deacetylase-6 induces contractile dysfunction through derailment of α-tubulin proteostasis in experimental and human atrial fibrillation
Autorzy:: Zhang, Deli
Wu, Chia-Tung
Qi, XiaoYan
Meijering, Roelien A.M.
Hoogstra-Berends, Femke
Tadevosyan, Artavazd
Cubukcuoglu Deniz, Gunseli
Durdu, Serkan
Akar, Ahmet Ruchan
Sibon, Ody C.M.
Nattel, Stanley
Henning, Robert H.
Brundel, Bianca J.J.M.; Pokaż więcej
Temat:: alpha-tubulin deacetylase
atrial fibrillation
Drosophila
epigenesis
genetic
HDAC6 protein
human
MICROTUBULE DISRUPTION
THERAPEUTIC TARGETS
STRUCTURAL-CHANGES
HDAC6 INHIBITOR
DISEASE
HEART
CYTOSKELETON
ACETYLATION
DEGRADATION
PROTEOLYSIS
Animals
Atrial Fibrillation/metabolism
Atrial Remodeling/physiology
Calpain/metabolism
Cardiac Pacing, Artificial
Dogs
Drosophila Proteins/antagonists & inhibitors
HeLa Cells
Histone Deacetylase 6
Histone Deacetylases/metabolism
Humans
Hydroxamic Acids/pharmacology
Indoles/pharmacology
Mice
Microtubules/metabolism
Myocardial Contraction/physiology
Myocytes, Cardiac/cytology
Tubulin/metabolism
Cardiac Pacing
Artificial
Myocytes
Cardiac/cytology
Physiology (medical)
Cardiology and Cardiovascular Medicine
HDAC6
Proteostasis
Histone
biology.protein
biology
Endocrinology
medicine.medical_specialty
medicine
Deacetylase activity
Internal medicine
Epigenetics
Calpain
Cell biology
Fibrillation
medicine.symptom
Acetylation
Źródło:: Circulation, 129(3), 346-358. LIPPINCOTT WILLIAMS & WILKINS
Circulation, 129(3), 346-58. Lippincott Williams and Wilkins
Dostępność:: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97b4426056393da1756ecfedfc62953d
https://research.rug.nl/en/publications/activation-of-histone-deacetylase6-induces-contractile-dysfunction-through-derailment-of-tubulin-proteostasis-in-experimental-and-human-atrial-fibrillation(fd549df7-2e22-47b2-960a-bffc9dd2da13).html

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Szczegóły

Skocz do pozycji: 14.

Tytuł:: Identification and characterization of mechanistically distinct inducers of gamma-globin transcription
Autorzy:: Haley, John D.
Smith, David E.
Schwedes, Janine
Brennan, Richard
Pearce, Cedric
Moore, Claudia
Wang, Faye
Petti, Fillipo
Grosveld, Frank
Jane, Stephen M.
Noguchi, Constance T.
Schechter, Alan N.; Pokaż więcej
Temat:: Histone Deacetylase Inhibitors
Anemia
Sickle Cell/*metabolism
Enzyme Inhibitors/*pharmacology
Erythroid Precursor Cells/metabolism
Fetal Hemoglobin/*metabolism
Globins/genetics/*metabolism
Histone Deacetylases/metabolism
Humans
K562 Cells
RNA
Messenger/metabolism
Transcription
Genetic/*drug effects
globin-switching
histone deacetylase
sickle disease
γ-globin transcription
Anemia, Sickle Cell/*metabolism
RNA, Messenger/metabolism
Transcription, Genetic/*drug effects
Article
Pharmacology
Biochemistry
Transfection
Globin
Transcription (biology)
Biology
Molecular biology
Cell culture
Locus control region
Fetal hemoglobin
Gene expression
Erythroid Precursor Cells
hemic and lymphatic diseases
Źródło:: Biochemical Pharmacology, 1-23
STARTPAGE=1;ENDPAGE=23;ISSN=00062952;TITLE=Biochemical Pharmacology
Biochemical Pharmacology, 66(9), 1755-1768
Opis pliku:: application/pdf
Dostępność:: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14dd61578ca48fbb0ef363f274a9c36d

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Skocz do pozycji: 15.

Tytuł:: Sodium Butyrate Stimulates Expression of Fibroblast Growth Factor 21 in Liver by Inhibition of Histone Deacetylase 3
Autorzy:: Li, Huating
Gao, Zhanguo
Zhang, Jin
Ye, Xin
Xu, Aimin
Ye, Jianping
Jia, Weiping; Pokaż więcej
Temat:: Endocrinology, Diabetes and Metabolism
Internal Medicine
Fatty acid
chemistry.chemical_classification
chemistry
Butyrate
Sodium butyrate
chemistry.chemical_compound
Histone deacetylase
Biology
Internal medicine
medicine.medical_specialty
medicine
HDAC3
Endocrinology
Ketone bodies
Ketogenesis
Trichostatin A
medicine.drug
Histone Deacetylases - metabolism
Bezafibrate - pharmacology
Butyrates - pharmacology
Fibroblast Growth Factors - genetics - metabolism
Gene Expression Regulation - drug effects - physiology
Metabolism
Źródło:: Diabetes
Dostępność:: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6611769b8da3912c3cf406adfaff4de

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Skocz do pozycji: 16.

Tytuł:: Epigenetic control of tissue-type plasminogen activator synthesis in human endothelial cells
Autorzy:: Sylvie Dunoyer-Geindre
Egbert K. O. Kruithof; Pokaż więcej
Temat:: ddc:616
Base Sequence
Cells, Cultured
DNA Methylation
DNA Primers/genetics
Endothelial Cells/drug effects/metabolism
Epigenesis, Genetic/drug effects
Hepatocytes/metabolism
Histone Deacetylase Inhibitors/pharmacology
Histone Deacetylases/metabolism
Histones/metabolism
Humans
Promoter Regions, Genetic
RNA, Messenger/genetics/metabolism
Tissue Plasminogen Activator/biosynthesis/genetics
Physiology (medical)
Cardiology and Cardiovascular Medicine
Physiology
Histone
biology.protein
biology
DNA methylation
PCAF
Histone deacetylase
Acetylation
Molecular biology
T-plasminogen activator
Plasminogen activator
Epigenetics
Źródło:: Cardiovascular Research, Vol. 90, No 3 (2011) pp. 457-63
Cardiovascular research
Dostępność:: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d74d00f0995ff382c4671138dfe0327
https://archive-ouverte.unige.ch/unige:36185

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Szczegóły

Skocz do pozycji: 17.

Tytuł:: Un virus tapi dans l’ombre : les bases moléculaires de la latence du VIH-1: Partie II : la réactivation de la latence du VIH-1 et ses implications thérapeutiques
Autorzy:: Cherrier, Thomas
Le Douce, Valentin
Redel, Laetitia
Marban, Celine
Aunis, Dominique
Rohr, Olivier
Schwartz, Christian; Pokaż więcej
Temat:: Sciences du Vivant [q-bio]/Biologie cellulaire
Disease Reservoirs
HIV Infections/drug therapy/physiopathology
HIV-1/genetics/physiology
Histone Deacetylase Inhibitors/therapeutic use
Histone Deacetylases/metabolism
Humans
RNA, Messenger/genetics
RNA, Viral/genetics
Virus Latency
Virus Replication
Biochemistry, biophysics & molecular biology [Life sciences]
Biochimie, biophysique & biologie moléculaire [Sciences du vivant]
Źródło:: Medecine Sciences : M/S, 26(3), 291-5. France (2010).
Dostępność:: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::8a141aa0cdac7783edcc001875e10d6e
http://www.medecinesciences.org/10.1051/medsci/2010263291

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Szczegóły

Skocz do pozycji: 18.

Tytuł:: Trans-acting antisense RNAs mediate transcriptional gene cosuppression in S. cerevisiae
Autorzy:: Lars M. Steinmetz
Guillaume Schlaepfer
Jurgi Camblong
Elisa Guffanti
Nissrine Beyrouthy
Françoise Stutz; Pokaż więcej
Temat:: Research Paper
Developmental Biology
Genetics
Non-coding RNA
Sense (molecular biology)
Argonaute
RNA interference
Biology
Small interfering RNA
Cosuppression
Antisense RNA
Gene silencing
ddc:570
DNA-Binding Proteins/metabolism
Gene Dosage/genetics
Gene Expression Regulation, Fungal
Gene Silencing
Histone Deacetylases/metabolism
Histone-Lysine N-Methyltransferase
Proton-Phosphate Symporters/genetics
RNA, Antisense/metabolism
Saccharomyces cerevisiae/genetics/metabolism
Saccharomyces cerevisiae Proteins/genetics/metabolism
Suppression, Genetic/genetics
Trans-Activators/metabolism
Transcription Factors/metabolism
Źródło:: Genes & development, Vol. 23, No 13 (2009) pp. 1534-45
Dostępność:: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44a276d92a9dd7821043a81395d98c36
https://europepmc.org/articles/PMC2704465/

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Szczegóły

Skocz do pozycji: 19.

Tytuł:: AKAP-Lbc mobilizes a cardiac hypertrophy signaling pathway
Autorzy:: F. Donelson Smith
Dario Diviani
John D. Scott
Lorene K. Langeberg
Alexandra C. Newton
Maya T. Kunkel
Graeme K. Carnegie
Michael R. Bristow
Fang Zhang
Benjamin S. Pedroja
Joseph Soughayer; Pokaż więcej
Temat:: Article
Cell Biology
Molecular Biology
Protein kinase C
Signal transduction
Biology
Nuclear export signal
A Kinase Anchor Proteins
Cell biology
Kinase activity
Histone deacetylase 5
Histone deacetylase
Regulation of gene expression
Molecular biology
14-3-3 Proteins/metabolism
A Kinase Anchor Proteins/genetics
A Kinase Anchor Proteins/metabolism
Active Transport, Cell Nucleus
Animals
COS Cells
Cardiomegaly/metabolism
Cell Line
Cercopithecus aethiops
Cyclic AMP-Dependent Protein Kinases/metabolism
Gene Expression Regulation
Guanine Nucleotide Exchange Factors/genetics
Guanine Nucleotide Exchange Factors/metabolism
Heart Ventricles/drug effects
Histone Deacetylases/metabolism
Humans
Models, Biological
Myocytes, Cardiac/drug effects
Myocytes, Cardiac/metabolism
Myogenic Regulatory Factors/metabolism
Phenylephrine/pharmacology
Phosphorylation
Protein Kinase C/metabolism
Proto-Oncogene Proteins/genetics
Proto-Oncogene Proteins/metabolism
RNA Interference
Rats
Signal Transduction
Źródło:: Molecular Cell, vol. 32, no. 2, pp. 169-179
Opis pliku:: application/pdf
Dostępność:: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::784529f321a20f89764ff93eefc37bb5
https://europepmc.org/articles/PMC3169907/

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Szczegóły

Skocz do pozycji: 20.

Tytuł:: Acetylation at lysine 346 controls the transforming activity of the HTLV-1 Tax oncoprotein in the Rat-1 fibroblast model
Autorzy:: Carla Sampaio
Pierre P. Roger
Françoise Bex
Katia Coulonval
Mathieu Boxus
Lucas Willems
Anne-Sophie Rinaldi
Julie Lodewick; Pokaż więcej
Temat:: Research
HTLV-1
Tax
Acetylation
CDK4
Transformation
Leukemia
Infectious Diseases
Virology
Immunology
P300-CBP Transcription Factors
Retinoblastoma protein
biology.protein
biology
SUMO protein
Histone deacetylase 5
Cell biology
Phosphorylation
Kinase activity
Ubiquitin
Physiologie de la régulation
Virologie médicale
Sciences bio-médicales et agricoles
Animals
Cell Line
Cell Transformation, Viral
Fibroblasts -- virology
Gene Products, tax -- metabolism
Histone Deacetylases -- metabolism
Human T-lymphotropic virus 1 -- pathogenicity
Humans
Lysine -- metabolism
Protein Processing, Post-Translational
Rats
p300-CBP Transcription Factors -- metabolism
Źródło:: Retrovirology
Retrovirology, 10
Opis pliku:: 1 full-text file(s): application/pdf
Dostępność:: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ee701f71482c8e8e3732ac7a311293e
http://europepmc.org/articles/PMC3734113

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