Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Wyszukujesz frazę ""Histone Deacetylases metabolism"" wg kryterium: Temat


Tytuł:
Proinflammatory Cytokines Perturb Mouse and Human Pancreatic Islet Circadian Rhythmicity and Induce Uncoordinated β-Cell Clock Gene Expression via Nitric Oxide, Lysine Deacetylases, and Immunoproteasomal Activity
Autorzy:
Nico Fischer
Peter Horskjær Rose
Tina Dahlby
Charna Dibner
Phillip Alexander Keller Andersen
Seyed Mojtaba Ghiasi
Melissa Koomen
Thomas Mandrup-Poulsen
Volodymyr Petrenko
Pokaż więcej
Temat:
chronobiology
diabetes
epigenetics
immuno-metabolism
nitric oxide synthase
Inorganic Chemistry
Organic Chemistry
Physical and Theoretical Chemistry
Computer Science Applications
Spectroscopy
Molecular Biology
General Medicine
Catalysis
CLOCK
HDAC3
Cell biology
Pancreatic islets
medicine.anatomical_structure
medicine
PER2
Proinflammatory cytokine
Chemistry
Knockout mouse
Viability assay
Nitric oxide synthase
biology.protein
biology
Nitric oxide
chemistry.chemical_compound
Cell
Islet
geography.geographical_feature_category
geography
Circadian rhythm
Epigenetics
Article
ddc:612
ddc:616
ARNTL Transcription Factors/genetics/metabolism
Animals
Cell Line
Tumor
Cells
Cultured
Circadian Rhythm
Female
HEK293 Cells
Histone Deacetylases/metabolism
Humans
Insulin/metabolism
Insulin-Secreting Cells/drug effects/metabolism
Interferon-gamma/metabolism/pharmacology
Male
Mice
Nitric Oxide/metabolism
Proteasome Endopeptidase Complex/metabolism
Reactive Oxygen Species/metabolism
lcsh:Biology (General)
lcsh:QH301-705.5
lcsh:Chemistry
lcsh:QD1-999
biochemistry
Źródło:
International Journal of Molecular Sciences
Volume 22
Issue 1
International Journal of Molecular Sciences, Vol. 22, No 1 (2020) P. 83
International Journal of Molecular Sciences, Vol 22, Iss 83, p 83 (2021)
Opis pliku:
application/pdf
Dostępność:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57f713196105e260c2898cb08ff9e574
Tytuł:
A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing
Autorzy:
Simoben, Conrad
Robaa, Dina
Chakrabarti, Alokta
Schmidtkunz, Karin
Marek, Martin
Lancelot, Julien
Kannan, Srinivasaraghavan
Melesina, Jelena
Shaik, Tajith
Pierce, Raymond
Romier, Christophe
Jung, Manfred
Sippl, Wolfgang
Pokaż więcej
Temat:
crystal structure
docking
epigenetics
histone deacetylase (HDAC) inhibitors
schistosomiasis
virtual screening
MESH: Animals
MESH: Anthelmintics/pharmacology
MESH: Hydroxamic Acids/chemical synthesis
MESH: Hydroxamic Acids/pharmacology
MESH: Apoptosis/drug effects
MESH: Molecular Docking Simulation
MESH: Protein Binding
MESH: Protein Interaction Domains and Motifs
MESH: Protein Structure, Secondary
MESH: Pyrrolidines/chemical synthesis
MESH: Pyrrolidines/pharmacology
MESH: Schistosoma mansoni/drug effects
MESH: Helminth Proteins/chemistry
MESH: Schistosoma mansoni/enzymology
MESH: Schistosoma mansoni/genetics
MESH: Schistosoma mansoni/growth & development
MESH: Binding Sites
MESH: Structure-Activity Relationship
MESH: Zinc/chemistry
MESH: Zinc/metabolism
MESH: Chelating Agents/chemical synthesis
MESH: Anthelmintics/chemical synthesis
MESH: Chelating Agents/pharmacology
MESH: Helminth Proteins/genetics
MESH: Crystallography, X-Ray
MESH: Gene Expression
MESH: Helminth Proteins/antagonists & inhibitors
MESH: Helminth Proteins/metabolism
MESH: Histone Deacetylase Inhibitors/chemical synthesis
MESH: Histone Deacetylase Inhibitors/pharmacology
MESH: Histone Deacetylases/chemistry
MESH: Histone Deacetylases/genetics
MESH: Histone Deacetylases/metabolism
[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM]
lcsh:Organic chemistry
lcsh:QD241-441
Animals
Anthelmintics/pharmacology
Hydroxamic Acids/chemical synthesis
Hydroxamic Acids/pharmacology
Apoptosis/drug effects
Molecular Docking Simulation
Protein Binding
Protein Interaction Domains and Motifs
Protein Structure, Secondary
Pyrrolidines/chemical synthesis
Pyrrolidines/pharmacology
Schistosoma mansoni/drug effects
Helminth Proteins/chemistry
Schistosoma mansoni/enzymology
Schistosoma mansoni/genetics
Schistosoma mansoni/growth & development
Binding Sites
Structure-Activity Relationship
Zinc/chemistry
Zinc/metabolism
Chelating Agents/chemical synthesis
Anthelmintics/chemical synthesis
Chelating Agents/pharmacology
Helminth Proteins/genetics
Crystallography, X-Ray
Gene Expression
Helminth Proteins/antagonists & inhibitors
Helminth Proteins/metabolism
Histone Deacetylase Inhibitors/chemical synthesis
Histone Deacetylase Inhibitors/pharmacology
Histone Deacetylases/chemistry
Histone Deacetylases/genetics
Histone Deacetylases/metabolism
Chemistry (miscellaneous)
Analytical Chemistry
Organic Chemistry
Physical and Theoretical Chemistry
Molecular Medicine
Drug Discovery
Pharmaceutical Science
Structure–activity relationship
Schistosoma mansoni
biology.organism_classification
biology
Virtual screening
Epigenome
Biochemistry
Chemistry
HDAC8
In silico
Docking (dog)
Article
Źródło:
Molecules
Molecules, MDPI, 2018, 23 (3), pp.566. ⟨10.3390/molecules23030566⟩
Molecules, Vol 23, Iss 3, p 566 (2018)
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Opis pliku:
application/octet-stream
Dostępność:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c57756972e5c4439f4e393638be3994b
https://hal.archives-ouvertes.fr/hal-02391176
Tytuł:
POWERDRESS-mediated histone deacetylation is essential for thermomorphogenesis in Arabidopsis thaliana
Autorzy:
David J. Tremethick
Avilash Singh Yadav
Celine Tasset
Sureshkumar Balasubramanian
Lennard van der Woude
Maxim Nekrasov
Sridevi Sureshkumar
Martijn van Zanten
Rupali Singh
Pokaż więcej
Temat:
Acetylation
Arabidopsis/genetics
Arabidopsis Proteins/genetics
Histone Deacetylases/metabolism
Histones/metabolism
Morphogenesis
Mutation
Temperature
Transcription Factors/genetics
Research Article
Biology and life sciences
Biochemistry
Proteins
DNA-binding proteins
Histones
Genetics
Gene Expression
Gene Regulation
Plant Science
Plant Anatomy
Fruit and Seed Anatomy
Plant Embryo Anatomy
Hypocotyl
Developmental Biology
Embryogenesis
Plant Embryogenesis
Plant Growth and Development
Plant Development
Computational Biology
Genome Analysis
Transcriptome Analysis
Genomics
Cell Biology
Chromosome Biology
Chromatin
Nucleosomes
Epigenetics
Research and Analysis Methods
Experimental Organism Systems
Model Organisms
Arabidopsis Thaliana
Organisms
Eukaryota
Plants
Brassica
Plant and Algal Models
Cancer Research
Genetics(clinical)
Molecular Biology
Ecology, Evolution, Behavior and Systematics
Chromatin remodeling
Histone
biology.protein
biology
Arabidopsis thaliana
biology.organism_classification
Nucleosome
HDAC9
Regulation of gene expression
Cell biology
SAP30
Histone H1
Histone H2A
Histone methylation
Histone code
Histone methyltransferase
lcsh:Genetics
lcsh:QH426-470
food and beverages
Źródło:
PLoS Genetics
PLoS Genetics, 14(3)
PLoS Genetics, Vol 14, Iss 3, p e1007280 (2018)
Opis pliku:
image/pdf
Dostępność:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d57a60975b88b4bf219bb7925e75a4bb
Tytuł:
The crystal structure of the Leishmania infantum Silent Information Regulator 2 related protein 1: Implications to protein function and drug design
Autorzy:
Ronin, Céline
Costa, David Mendes
Tavares, Joana
Faria, Joana
Ciesielski, Fabrice
Ciapetti, Paola
Smith, Terry K.
MacDougall, Jane
Cordeiro-da-Silva, Anabela
Pemberton, Iain K.
Pokaż więcej
Temat:
Binding Site
Crystallography, X-Ray
Drug Design
Group III Histone Deacetylases / chemistry
Group III Histone Deacetylases / metabolism
Humans
Leishmania infantum / metabolismo
Models, Molecular
Peptides / metabolism
Protein Binding
Protein Structure, Secondary
Protozoan Proteins / chemistry
Protozoan Proteins / metabolism
lcsh:Medicine
lcsh:R
lcsh:Science
lcsh:Q
QH301 Biology
RM Therapeutics. Pharmacology
DAS
QH301
RM
Multidisciplinary
Amino acid
chemistry.chemical_classification
chemistry
SIRT2
Function (biology)
Protein structure
Cofactor binding
Cell biology
Sirtuin
biology.protein
biology
Acetylation
Leishmania infantum
biology.organism_classification
Research Article
Physical Sciences
Physics
Condensed Matter Physics
Solid State Physics
Crystallography
Crystal Structure
Biology and Life Sciences
Molecular Biology
Molecular Biology Techniques
Mutagenesis and Gene Deletion Techniques
Deletion Mutagenesis
Research and Analysis Methods
Biochemistry
Enzymology
Enzymes
Proteases
Serine Proteases
Proteins
Macromolecular Structure Analysis
Protein Structure
Recombinant Proteins
Microbiology
Protozoology
Kinetoplastids
Developmental Biology
Life Cycles
Protozoan Life Cycles
Promastigotes
Chemistry
Chemical Compounds
Organic Compounds
Amino Acids
Hydroxyl Amino Acids
Serine
Organic Chemistry
Źródło:
PLoS ONE, Vol 13, Iss 3, p e0193602 (2018)
PLoS ONE
Opis pliku:
application/pdf
Dostępność:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88cfc4b29d9187320b8ad4cb262ede39
Tytuł:
HDAC3 is a molecular brake of the metabolic switch supporting white adipose tissue browning
Autorzy:
Ferrari, Alessandra
Longo, Raffaella
Fiorino, Erika
Silva, Rui
Mitro, Nico
Cermenati, Gaia
Gilardi, Federica
Desvergne, Béatrice
Andolfo, Annapaola
Magagnotti, Cinzia
Caruso, Donatella
Fabiani, Emma De
Hiebert, Scott W.
Crestani, Maurizio
Pokaż więcej
Temat:
Article
Adipocytes/physiology
Adipose Tissue, Brown/physiology
Adipose Tissue, White/physiology
Animals
Cell Line
Diet, High-Fat
Gene Expression Regulation/physiology
Gene Silencing
Histone Deacetylases/genetics
Histone Deacetylases/metabolism
Lipid Metabolism
Male
Mice
Mice, Knockout
lcsh:Science
lcsh:Q
General Physics and Astronomy
General Biochemistry, Genetics and Molecular Biology
General Chemistry
White adipose tissue
Futile cycle
Fatty acid metabolism
chemistry.chemical_compound
chemistry
HDAC3
Lipid metabolism
Adipose tissue
Biology
Biochemistry
Fatty acid synthesis
PPARA Gene
adipocytes
adipose tissue, brown
adipose tissue, white
animals
cell line
diet, high-fat
gene expression regulation
gene silencing
histone deacetylases
lipid metabolism
male
mice
mice, knockout
chemistry (all)
biochemistry, genetics and molecular biology (all)
Settore BIO/10 - Biochimica
food and beverages
nutritional and metabolic diseases
hormones, hormone substitutes, and hormone antagonists
lipids (amino acids, peptides, and proteins)
Źródło:
Nature Communications
Nature Communications, vol. 8, no. 1, pp. 93
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Opis pliku:
application/pdf
Dostępność:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c512383fec48820206bfc3269b78fc0b
http://europepmc.org/articles/PMC5522415
Tytuł:
The fusion protein SS18-SSX1 employs core Wnt pathway transcription factors to induce a partial Wnt signature in synovial sarcoma
Autorzy:
Cironi, Luisa
Petricevic, Tanja
Fernandes Vieira, Victor
Provero, Paolo
Fusco, Carlo
Cornaz, Sandrine
Fregni, Giulia
Letovanec, Igor
Aguet, Michel
Stamenkovic, Ivan
Pokaż więcej
Temat:
Multidisciplinary
AXIN2
LRP5
Wnt signaling pathway
Fusion protein
TCF/LEF family
Cancer research
LRP6
Beta-catenin
biology.protein
biology
Transcription factor
Animals
Axin Protein
Blotting, Western
Cell Line
Cell Line, Tumor
Gene Expression Profiling
Histone Deacetylases
Humans
Mice
Microscopy, Confocal
Oncogene Proteins, Fusion
RNA Interference
Repressor Proteins
Reverse Transcriptase Polymerase Chain Reaction
Sarcoma, Synovial
TCF Transcription Factors
Transcription Factors
Wnt Signaling Pathway
beta Catenin
Axin Protein/genetics
Axin Protein/metabolism
Gene Expression Profiling/methods
Histone Deacetylases/genetics
Histone Deacetylases/metabolism
Oncogene Proteins, Fusion/genetics
Oncogene Proteins, Fusion/metabolism
Repressor Proteins/genetics
Repressor Proteins/metabolism
Sarcoma, Synovial/genetics
Sarcoma, Synovial/metabolism
Sarcoma, Synovial/pathology
TCF Transcription Factors/genetics
TCF Transcription Factors/metabolism
Transcription Factors/genetics
Transcription Factors/metabolism
Wnt Signaling Pathway/genetics
beta Catenin/genetics
beta Catenin/metabolism
Article
Źródło:
Scientific reports, vol. 6, pp. 22113
Scientific Reports
Opis pliku:
application/pdf
Dostępność:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60efadcc1928d9d1f484ba21cc89d788
Tytuł:
Activation of histone deacetylase-6 induces contractile dysfunction through derailment of α-tubulin proteostasis in experimental and human atrial fibrillation
Autorzy:
Zhang, Deli
Wu, Chia-Tung
Qi, XiaoYan
Meijering, Roelien A.M.
Hoogstra-Berends, Femke
Tadevosyan, Artavazd
Cubukcuoglu Deniz, Gunseli
Durdu, Serkan
Akar, Ahmet Ruchan
Sibon, Ody C.M.
Nattel, Stanley
Henning, Robert H.
Brundel, Bianca J.J.M.
Pokaż więcej
Temat:
alpha-tubulin deacetylase
atrial fibrillation
Drosophila
epigenesis
genetic
HDAC6 protein
human
MICROTUBULE DISRUPTION
THERAPEUTIC TARGETS
STRUCTURAL-CHANGES
HDAC6 INHIBITOR
DISEASE
HEART
CYTOSKELETON
ACETYLATION
DEGRADATION
PROTEOLYSIS
Animals
Atrial Fibrillation/metabolism
Atrial Remodeling/physiology
Calpain/metabolism
Cardiac Pacing, Artificial
Dogs
Drosophila Proteins/antagonists & inhibitors
HeLa Cells
Histone Deacetylase 6
Histone Deacetylases/metabolism
Humans
Hydroxamic Acids/pharmacology
Indoles/pharmacology
Mice
Microtubules/metabolism
Myocardial Contraction/physiology
Myocytes, Cardiac/cytology
Tubulin/metabolism
Cardiac Pacing
Artificial
Myocytes
Cardiac/cytology
Physiology (medical)
Cardiology and Cardiovascular Medicine
HDAC6
Proteostasis
Histone
biology.protein
biology
Endocrinology
medicine.medical_specialty
medicine
Deacetylase activity
Internal medicine
Epigenetics
Calpain
Cell biology
Fibrillation
medicine.symptom
Acetylation
Źródło:
Circulation, 129(3), 346-358. LIPPINCOTT WILLIAMS & WILKINS
Circulation, 129(3), 346-58. Lippincott Williams and Wilkins
Dostępność:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97b4426056393da1756ecfedfc62953d
https://research.rug.nl/en/publications/activation-of-histone-deacetylase6-induces-contractile-dysfunction-through-derailment-of-tubulin-proteostasis-in-experimental-and-human-atrial-fibrillation(fd549df7-2e22-47b2-960a-bffc9dd2da13).html

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies

Prześlij opinię

Twoje opinie są dla nas bardzo ważne i mogą być niezwykle pomocne w pokazaniu nam, gdzie możemy dokonać ulepszeń. Bylibyśmy bardzo wdzięczni za poświęcenie kilku chwil na wypełnienie krótkiego formularza.

Formularz