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Wyszukujesz frazę ""Histone Demethylases"" wg kryterium: Temat


Tytuł :
Lysine Demethylase KDM6A in Differentiation, Development, and Cancer.
Autorzy :
Tran N; Laboratory of Endocrinology and Receptor Biology, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA.
Broun A; Laboratory of Endocrinology and Receptor Biology, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA.
Ge K; Laboratory of Endocrinology and Receptor Biology, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA .
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Źródło :
Molecular and cellular biology [Mol Cell Biol] 2020 Sep 28; Vol. 40 (20). Date of Electronic Publication: 2020 Sep 28 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural; Review
MeSH Terms :
Cell Differentiation/*genetics
Gene Expression Regulation/*genetics
Histone Demethylases/*genetics
Neoplasms/*genetics
Catalytic Domain/genetics ; Chromatin Assembly and Disassembly/genetics ; Embryonic Stem Cells/cytology ; Genes, Tumor Suppressor ; Histone Demethylases/metabolism ; Humans ; Jumonji Domain-Containing Histone Demethylases/metabolism ; Nuclear Proteins/metabolism
Czasopismo naukowe
Tytuł :
H3K27me3 demethylase UTX regulates the differentiation of a subset of bipolar cells in the mouse retina.
Autorzy :
Umutoni D; Division of Molecular and Developmental Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.; Department of Ophthalmology, University of Tokyo, Tokyo, Japan.
Iwagawa T; Division of Molecular and Developmental Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
Baba Y; Division of Molecular and Developmental Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
Tsuhako A; Division of Molecular and Developmental Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
Honda H; Field of Human Disease Models, Major in Advanced Life Sciences and Medicine, Institute of Laboratory Animals, Tokyo Women's Medical University, Tokyo, Japan.
Aihara M; Department of Ophthalmology, University of Tokyo, Tokyo, Japan.
Watanabe S; Division of Molecular and Developmental Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
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Źródło :
Genes to cells : devoted to molecular & cellular mechanisms [Genes Cells] 2020 Jun; Vol. 25 (6), pp. 402-412. Date of Electronic Publication: 2020 Apr 14.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Differentiation/*genetics
Histone Demethylases/*metabolism
Retina/*metabolism
Retinal Bipolar Cells/*metabolism
Animals ; Apoptosis/genetics ; Cell Lineage ; Cell Proliferation/genetics ; Gene Expression Regulation, Developmental/genetics ; Gene Knockdown Techniques ; Histone Demethylases/genetics ; Jumonji Domain-Containing Histone Demethylases/genetics ; Jumonji Domain-Containing Histone Demethylases/metabolism ; Methylation ; Mice ; Mice, Knockout ; Protein Kinase C-alpha/metabolism ; RNA Interference ; Retina/embryology ; Retina/enzymology ; Retinal Bipolar Cells/cytology ; Retinal Bipolar Cells/enzymology ; Retinal Rod Photoreceptor Cells/cytology ; Retinal Rod Photoreceptor Cells/metabolism
Czasopismo naukowe
Tytuł :
Cancer-derived UTX TPR mutations G137V and D336G impair interaction with MLL3/4 complexes and affect UTX subcellular localization.
Autorzy :
Kato H; Cancer Science Institute of Singapore, National University of Singapore, 14 Medical Drive, Singapore, 117599, Republic of Singapore. .; Department of Genome Medicine, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya, Tokyo, 156-8506, Japan. .; Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Science, Mizuho-ku, Nagoya, 467-860, Japan. .
Asamitsu K; Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Science, Mizuho-ku, Nagoya, 467-860, Japan.
Sun W; Cancer Science Institute of Singapore, National University of Singapore, 14 Medical Drive, Singapore, 117599, Republic of Singapore.
Kitajima S; Cancer Science Institute of Singapore, National University of Singapore, 14 Medical Drive, Singapore, 117599, Republic of Singapore.; The Institute for Advanced Biosciences, Keio University, Kakuganji 246-2, Mizukami, Tsuruoka, Yamagata, 997-0052, Japan.
Yoshizawa-Sugata N; Department of Genome Medicine, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya, Tokyo, 156-8506, Japan.
Okamoto T; Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Science, Mizuho-ku, Nagoya, 467-860, Japan.
Masai H; Department of Genome Medicine, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya, Tokyo, 156-8506, Japan.
Poellinger L; Cancer Science Institute of Singapore, National University of Singapore, 14 Medical Drive, Singapore, 117599, Republic of Singapore.; Department of Cell and Molecular Biology, Karolinska Institutet, SE-171 77, Stockholm, Sweden.
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Źródło :
Oncogene [Oncogene] 2020 Apr; Vol. 39 (16), pp. 3322-3335. Date of Electronic Publication: 2020 Feb 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Colorectal Neoplasms/*genetics
DNA-Binding Proteins/*genetics
Histone Demethylases/*genetics
Nuclear Proteins/*genetics
Tetratricopeptide Repeat/*genetics
Transcription Factors/*genetics
Amino Acid Substitution/genetics ; CRISPR-Cas Systems/genetics ; Cell Cycle Proteins/genetics ; Colorectal Neoplasms/pathology ; Gene Expression Regulation, Neoplastic/genetics ; HCT116 Cells ; Histone-Lysine N-Methyltransferase/genetics ; Humans ; Jumonji Domain-Containing Histone Demethylases/genetics ; Mutation/genetics
Czasopismo naukowe
Tytuł :
Lysine-specific histone demethylase 1A (LSD1) in cervical cancer.
Autorzy :
Beilner D; Department of Obstetrics and Gynaecology, LMU Munich, Marchioninistraße 15, 81377, Munich, Germany.
Kuhn C; Department of Obstetrics and Gynaecology, LMU Munich, Marchioninistraße 15, 81377, Munich, Germany.
Kost BP; Department of Obstetrics and Gynaecology, LMU Munich, Marchioninistraße 15, 81377, Munich, Germany.
Jückstock J; Department of Obstetrics and Gynaecology, LMU Munich, Marchioninistraße 15, 81377, Munich, Germany.
Mayr D; Department of Pathology, LMU Munich, Thalkirchner Str. 56, 80337, Munich, Germany.
Schmoeckel E; Department of Pathology, LMU Munich, Thalkirchner Str. 56, 80337, Munich, Germany.
Dannecker C; Department of Obstetrics and Gynaecology, University Hospital Augsburg, Stenglinstr. 2, 86156, Augsburg, Germany.
Mahner S; Department of Obstetrics and Gynaecology, LMU Munich, Marchioninistraße 15, 81377, Munich, Germany.
Jeschke U; Department of Obstetrics and Gynaecology, LMU Munich, Marchioninistraße 15, 81377, Munich, Germany. .; Department of Obstetrics and Gynaecology, University Hospital Augsburg, Stenglinstr. 2, 86156, Augsburg, Germany. .
Heidegger HH; Department of Obstetrics and Gynaecology, LMU Munich, Marchioninistraße 15, 81377, Munich, Germany.
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Źródło :
Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2020 Nov; Vol. 146 (11), pp. 2843-2850. Date of Electronic Publication: 2020 Jul 28.
Typ publikacji :
Journal Article
MeSH Terms :
Adenocarcinoma/*enzymology
Carcinoma, Squamous Cell/*enzymology
Histone Demethylases/*metabolism
Uterine Cervical Neoplasms/*enzymology
Adenocarcinoma/pathology ; Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/analysis ; Carcinoma, Squamous Cell/pathology ; Female ; Histone Demethylases/analysis ; Humans ; Middle Aged ; Uterine Cervical Neoplasms/pathology
Czasopismo naukowe
Tytuł :
Alternative isoforms of KDM2A and KDM2B lysine demethylases negatively regulate canonical Wnt signaling.
Autorzy :
Lađinović D; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic.
Pinkas D; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic.
Šopin T; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic.
Raška O; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic.
Liška F; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic.
Raška I; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic.
Vacík T; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic.
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Źródło :
PloS one [PLoS One] 2020 Oct 26; Vol. 15 (10), pp. e0236612. Date of Electronic Publication: 2020 Oct 26 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation*
Promoter Regions, Genetic*
Wnt Signaling Pathway*
Cyclin D1/*metabolism
F-Box Proteins/*metabolism
Jumonji Domain-Containing Histone Demethylases/*metabolism
Transcription Factor 7-Like 1 Protein/*metabolism
CpG Islands ; Cyclin D1/genetics ; F-Box Proteins/genetics ; HEK293 Cells ; Humans ; Jumonji Domain-Containing Histone Demethylases/genetics ; Lysine/genetics ; Lysine/metabolism ; Protein Isoforms ; Transcription Factor 7-Like 1 Protein/genetics
Czasopismo naukowe
Tytuł :
LncRNA LOXL1-AS1 is transcriptionally activated by JUND and contributes to osteoarthritis progression via targeting the miR-423-5p/KDM5C axis.
Autorzy :
Chen K; Department of Orthopaedics, Shanghai Eighth People's Hospital, 14th Floor, Building2, No.8 Caobao Road, Xuhui District, Shanghai 200235, China. Electronic address: .
Fang H; Department of Orthopaedics, Shanghai Eighth People's Hospital, 14th Floor, Building2, No.8 Caobao Road, Xuhui District, Shanghai 200235, China.
Xu N; Department of Orthopaedics, Shanghai Eighth People's Hospital, 14th Floor, Building2, No.8 Caobao Road, Xuhui District, Shanghai 200235, China.
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Źródło :
Life sciences [Life Sci] 2020 Oct 01; Vol. 258, pp. 118095. Date of Electronic Publication: 2020 Jul 14.
Typ publikacji :
Journal Article
MeSH Terms :
Signal Transduction*
Transcription, Genetic*
Histone Demethylases/*metabolism
MicroRNAs/*metabolism
Osteoarthritis/*genetics
Proto-Oncogene Proteins c-jun/*metabolism
RNA, Long Noncoding/*metabolism
Apoptosis/genetics ; Base Sequence ; Cell Proliferation/genetics ; Chondrocytes/metabolism ; Chondrocytes/pathology ; Disease Progression ; Gene Silencing ; Histone Demethylases/genetics ; Humans ; Inflammation/genetics ; Inflammation/pathology ; MicroRNAs/genetics ; Osteoarthritis/pathology ; RNA, Long Noncoding/genetics
Czasopismo naukowe
Tytuł :
Therapeutically targeting head and neck squamous cell carcinoma through synergistic inhibition of LSD1 and JMJD3 by TCP and GSK-J1.
Autorzy :
Zhang W; Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University, 210029, Nanjing, P. R. China.
Cheng J; Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University, 210029, Nanjing, P. R. China.
Diao P; Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University, 210029, Nanjing, P. R. China.
Wang D; Department of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital, Nanjing Medical University, 210029, Nanjing, P. R. China.
Zhang W; Department of Oral Pathology, Affiliated Stomatological Hospital, Nanjing Medical University, 210029, Nanjing, P. R. China.
Jiang H; Department of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital, Nanjing Medical University, 210029, Nanjing, P. R. China.
Wang Y; Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University, 210029, Nanjing, P. R. China. .
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Źródło :
British journal of cancer [Br J Cancer] 2020 Feb; Vol. 122 (4), pp. 528-538. Date of Electronic Publication: 2019 Dec 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Squamous Cell Carcinoma of Head and Neck*
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Benzazepines/*pharmacology
Histone Demethylases/*antagonists & inhibitors
Pyrimidines/*pharmacology
Tranylcypromine/*pharmacology
Animals ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Drug Synergism ; Enzyme Inhibitors/pharmacology ; Humans ; Jumonji Domain-Containing Histone Demethylases/antagonists & inhibitors ; Mice ; Mice, Inbred C57BL ; Mice, Nude ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Nascent transcript and single-cell RNA-seq analysis defines the mechanism of action of the LSD1 inhibitor INCB059872 in myeloid leukemia.
Autorzy :
Johnston G; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Ramsey HE; Department of Medicine and Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
Liu Q; Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 37203, USA; Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Wang J; Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 37203, USA; Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Stengel KR; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Sampathi S; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Acharya P; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Arrate M; Department of Medicine and Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
Stubbs MC; Incyte Corporation, Wilmington, DE 19803, USA.
Burn T; Incyte Corporation, Wilmington, DE 19803, USA.
Savona MR; Department of Medicine and Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37203, USA; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37027, USA.
Hiebert SW; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37027, USA. Electronic address: .
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Źródło :
Gene [Gene] 2020 Aug 20; Vol. 752, pp. 144758. Date of Electronic Publication: 2020 May 15.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Leukemic/*drug effects
Histone Demethylases/*antagonists & inhibitors
Leukemia, Myeloid, Acute/*metabolism
Animals ; Antineoplastic Agents/pharmacology ; Cell Differentiation/drug effects ; Cell Line, Tumor ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Female ; Histone Demethylases/genetics ; Histone Demethylases/metabolism ; Humans ; Leukemia, Myeloid, Acute/genetics ; Mice ; Mice, Inbred C57BL ; RNA-Seq ; Single-Cell Analysis/methods ; Stem Cells/metabolism ; THP-1 Cells ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Whole Exome Sequencing/methods
Czasopismo naukowe
Tytuł :
JMJD5 couples with CDK9 to release the paused RNA polymerase II.
Autorzy :
Liu H; Department of Biomedical Research, National Jewish Health, Denver, CO 80206.; Department of Immunology and Microbiology, School of Medicine, University of Colorado Denver, Aurora, CO 80216.
Ramachandran S; RNA Bioscience Initiative and Department of Genetics and Biochemistry, School of Medicine, University of Colorado Denver, Aurora, CO 80216.
Fong N; RNA Bioscience Initiative and Department of Genetics and Biochemistry, School of Medicine, University of Colorado Denver, Aurora, CO 80216.
Phang T; Department of Biostatistics and Informatics, School of Medicine, University of Colorado Denver, Aurora, CO 80216.
Lee S; Department of Biomedical Research, National Jewish Health, Denver, CO 80206.; Department of Immunology and Microbiology, School of Medicine, University of Colorado Denver, Aurora, CO 80216.
Parsa P; NanoTemper Technologies, Inc., South San Francisco, CA 94080.
Liu X; Department of Hematology, Duke University, Durham, NC 27710.
Harmacek L; Department of Biomedical Research, National Jewish Health, Denver, CO 80206.
Danhorn T; Department of Biomedical Research, National Jewish Health, Denver, CO 80206.
Song T; Department of Biomedical Research, National Jewish Health, Denver, CO 80206.
Oh S; Department of Cell Biology, University of Oklahoma, Oklahoma City, OK 73104.
Zhang Q; School of Life Science, China Agricultural University, 100101 Beijing, People's Republic of China.
Chen Z; School of Life Science, China Agricultural University, 100101 Beijing, People's Republic of China.
Zhang Q; Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523.
Tu TH; Department of Biomedical Research, National Jewish Health, Denver, CO 80206.
Happoldt C; Department of Biomedical Research, National Jewish Health, Denver, CO 80206.
O'Conner B; Department of Biomedical Research, National Jewish Health, Denver, CO 80206.
Janknecht R; Department of Cell Biology, University of Oklahoma, Oklahoma City, OK 73104.
Li CY; Department of Hematology, Duke University, Durham, NC 27710.
Marrack P; Department of Biomedical Research, National Jewish Health, Denver, CO 80206.; Department of Immunology and Microbiology, School of Medicine, University of Colorado Denver, Aurora, CO 80216.
Kappler J; Department of Biomedical Research, National Jewish Health, Denver, CO 80206; .; Department of Immunology and Microbiology, School of Medicine, University of Colorado Denver, Aurora, CO 80216.
Leach S; Department of Biomedical Research, National Jewish Health, Denver, CO 80206.
Zhang G; Department of Biomedical Research, National Jewish Health, Denver, CO 80206; .; Department of Immunology and Microbiology, School of Medicine, University of Colorado Denver, Aurora, CO 80216.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Aug 18; Vol. 117 (33), pp. 19888-19895. Date of Electronic Publication: 2020 Aug 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription, Genetic*
Cyclin-Dependent Kinase 9/*metabolism
Histone Demethylases/*metabolism
RNA Polymerase II/*metabolism
Cell Line, Tumor ; Cyclin-Dependent Kinase 9/genetics ; Histone Demethylases/chemistry ; Histone Demethylases/genetics ; Humans ; Nucleosomes/genetics ; Nucleosomes/metabolism ; Phosphorylation ; Positive Transcriptional Elongation Factor B/genetics ; Positive Transcriptional Elongation Factor B/metabolism ; Promoter Regions, Genetic ; Protein Binding ; Protein Domains ; RNA Polymerase II/genetics
Czasopismo naukowe
Tytuł :
Jumonji domain containing-3 (JMJD3) inhibition attenuates IL-1β-induced chondrocytes damage in vitro and protects osteoarthritis cartilage in vivo.
Autorzy :
Jun Z; Department of Orthopaedics, Gongli Hospital, The Second Military Medical University, No. 219, Miaopu Road, Pudong New Area, Shanghai, 200135, People's Republic of China.
Xinmeng J; Department of Orthopaedics, Gongli Hospital, The Second Military Medical University, No. 219, Miaopu Road, Pudong New Area, Shanghai, 200135, People's Republic of China.
Yue L; Department of Orthopaedics, Gongli Hospital, The Second Military Medical University, No. 219, Miaopu Road, Pudong New Area, Shanghai, 200135, People's Republic of China.
Zhi W; Department of Orthopaedics, Gongli Hospital, The Second Military Medical University, No. 219, Miaopu Road, Pudong New Area, Shanghai, 200135, People's Republic of China.
Yan Z; Department of Orthopaedics, Gongli Hospital, The Second Military Medical University, No. 219, Miaopu Road, Pudong New Area, Shanghai, 200135, People's Republic of China.
Tieyi Y; Department of Orthopaedics, Gongli Hospital, The Second Military Medical University, No. 219, Miaopu Road, Pudong New Area, Shanghai, 200135, People's Republic of China.
Jiangan T; Department of Orthopaedics, Gongli Hospital, The Second Military Medical University, No. 219, Miaopu Road, Pudong New Area, Shanghai, 200135, People's Republic of China. .
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Źródło :
Inflammation research : official journal of the European Histamine Research Society ... [et al.] [Inflamm Res] 2020 Jul; Vol. 69 (7), pp. 657-666. Date of Electronic Publication: 2020 May 11.
Typ publikacji :
Journal Article
MeSH Terms :
Benzazepines/*pharmacology
Cartilage/*drug effects
Chondrocytes/*drug effects
Jumonji Domain-Containing Histone Demethylases/*antagonists & inhibitors
Osteoarthritis/*prevention & control
Pyrimidines/*pharmacology
Aggrecans/metabolism ; Animals ; Cartilage/physiopathology ; Cell Line ; Chondrocytes/physiology ; Collagen/metabolism ; Gene Expression ; Humans ; Inflammation/prevention & control ; Interleukin-1beta/pharmacology ; Jumonji Domain-Containing Histone Demethylases/genetics ; Jumonji Domain-Containing Histone Demethylases/physiology ; Mice ; Mice, Inbred C57BL ; NF-kappa B/metabolism ; Osteoarthritis/physiopathology ; Rats ; Signal Transduction/physiology
Czasopismo naukowe
Tytuł :
Inhibition of LSD1 in MDS progenitors restores differentiation of CD141 conventional dendritic cells.
Autorzy :
Srivastava P; Department of Medicine, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA.
Tzetzo SL; Department of Immunology, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA.
Gomez EC; Department of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA.
Eng KH; Department of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA.
Jani Sait SN; Department of Pathology and Laboratory Medicine, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA.
Kuechle JB; Department of Orthopaedics, University at Buffalo, Buffalo, NY, USA.
Singh PK; Center for Personalized Medicine, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA.
De Jong K; Flow and Image Cytometry Shared Resource, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA.
Wiatrowski KR; Department of Medicine, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA.
Peresie J; Department of Medicine, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA.
Dimitroff A; Department of Medicine, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA.
Lynch ML; Department of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA.
Wang J; Department of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA.
Abrams SI; Department of Immunology, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA.
Griffiths EA; Department of Medicine, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA. .; Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA. .
Nemeth MJ; Department of Medicine, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA. .; Department of Immunology, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA. .
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Źródło :
Leukemia [Leukemia] 2020 Sep; Vol. 34 (9), pp. 2460-2472. Date of Electronic Publication: 2020 Feb 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Differentiation*/genetics
Antigens, Surface/*immunology
Dendritic Cells/*cytology
Histone Demethylases/*antagonists & inhibitors
Myelodysplastic Syndromes/*pathology
Neoplastic Stem Cells/*pathology
Animals ; Dendritic Cells/immunology ; Epigenesis, Genetic ; Female ; Histone Demethylases/metabolism ; Humans ; Interferon Regulatory Factors/metabolism ; Mice ; Mice, Knockout ; Neoplastic Stem Cells/metabolism
Czasopismo naukowe
Tytuł :
Biological roles of LSD1 beyond its demethylase activity.
Autorzy :
Gu F; Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences, Hangzhou, China.; Department of Radiation Oncology, Cancer Hospital of the University of Chinese Academy of Sciences, Hangzhou, China.; Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou, China.
Lin Y; Department of Oncology, Hospital of Chinese Medicine of Changxing County, Huzhou, 313100, China.
Wang Z; Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences, Hangzhou, China.; Department of Radiation Oncology, Cancer Hospital of the University of Chinese Academy of Sciences, Hangzhou, China.; Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou, China.
Wu X; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Ye Z; Department of Respiratory Diseases, Hwa Mei Hospital, University of Chinese Academy Sciences, Ningbo, China.
Wang Y; Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences, Hangzhou, China. .; Department of Radiation Oncology, Cancer Hospital of the University of Chinese Academy of Sciences, Hangzhou, China. .; Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou, China. .
Lan H; Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences, Hangzhou, China. .; Department of Radiation Oncology, Cancer Hospital of the University of Chinese Academy of Sciences, Hangzhou, China. .; Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou, China. .
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Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2020 Sep; Vol. 77 (17), pp. 3341-3350. Date of Electronic Publication: 2020 Mar 19.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Histone Demethylases/*metabolism
Autophagy ; Demethylation ; F-Box-WD Repeat-Containing Protein 7/metabolism ; Histone Demethylases/chemistry ; Histones/metabolism ; Humans ; Neoplasms/metabolism ; Neoplasms/pathology ; Proteasome Endopeptidase Complex/metabolism ; Sequestosome-1 Protein/metabolism ; Ubiquitination
Czasopismo naukowe
Tytuł :
Precise separation of lysine-specific demethylase 1 inhibitors from Corydalis yanhusuo using multi-mode counter-current chromatography guided by virtual screening.
Autorzy :
Lin Y; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Bioactive Natural Product Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China.
Luo J; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Bioactive Natural Product Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China.
Li L; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Bioactive Natural Product Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China.
Liu X; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Bioactive Natural Product Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China.
Wang W; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Bioactive Natural Product Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China.
Zhu L; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Bioactive Natural Product Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China.
Han C; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Bioactive Natural Product Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China. Electronic address: .
Kong L; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Bioactive Natural Product Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China. Electronic address: .
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Źródło :
Journal of chromatography. A [J Chromatogr A] 2020 Aug 16; Vol. 1625, pp. 461294. Date of Electronic Publication: 2020 Jun 03.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Evaluation, Preclinical*
User-Computer Interface*
Corydalis/*chemistry
Countercurrent Distribution/*methods
Enzyme Inhibitors/*isolation & purification
Histone Demethylases/*antagonists & inhibitors
Biological Assay ; Cell Line, Tumor ; Cell Movement/drug effects ; Chromatography, High Pressure Liquid ; Enzyme Inhibitors/chemistry ; Histone Demethylases/metabolism ; Humans ; Hydrogen-Ion Concentration ; Molecular Docking Simulation ; Solvents ; Tandem Mass Spectrometry
Czasopismo naukowe
Tytuł :
MiR-134-5p Regulates Myocardial Apoptosis and Angiogenesis by Directly Targeting KDM2A After Myocardial Infarction.
Autorzy :
Li X; Department of Heart Disease, Affiliated Hospital to Changchun University of Chinese Medicine.
Wei C; Department of Cardiology, Chongming Branch Xinhua Hospital affiliated to Medical College of Shanghai Jiaotong University.
Zhang Z; Department of Heart Disease, Affiliated Hospital to Changchun University of Chinese Medicine.
Jin Q; Department of Heart Disease, Affiliated Hospital to Changchun University of Chinese Medicine.
Xiao X; Department of Heart Disease, Affiliated Hospital to Changchun University of Chinese Medicine.
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Źródło :
International heart journal [Int Heart J] 2020 Jul 30; Vol. 61 (4), pp. 815-821. Date of Electronic Publication: 2020 Jul 18.
Typ publikacji :
Journal Article
MeSH Terms :
Jumonji Domain-Containing Histone Demethylases/*metabolism
MicroRNAs/*metabolism
Myocardial Infarction/*metabolism
Animals ; Apoptosis ; Jumonji Domain-Containing Histone Demethylases/genetics ; Male ; Mice, Inbred C57BL ; Neovascularization, Physiologic
Czasopismo naukowe
Tytuł :
Downregulation of Jumonji-C domain-containing protein 5 inhibits proliferation by silibinin in the oral cancer PDTX model.
Autorzy :
Yang CY; School of Dentistry, National Defense Medical Center, Taipei, Taiwan, R.O.C.
Tsao CH; Department of Microbiology and Immunology, National Defense Medical Center, Taipei, Taiwan, R.O.C.; Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, R.O.C.
Hsieh CC; Department of Pharmacy Practice, Tri-Service General Hospital, Taipei, Taiwan, R.O.C.
Lin CK; Division of Anatomic Pathology, Taipei Tzu Chi Hospital, Taipei, Taiwan, R.O.C.
Lin CS; Department of Radiation Oncology, Tri-Service General Hospital, National Defense Medical Centre, Taipei, Taiwan, R.O.C.; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, R.O.C.
Li YH; School of Dentistry, National Defense Medical Center, Taipei, Taiwan, R.O.C.; Department of Oral and Maxillofacial Surgery, Tri-Service General Hospital, Taipei, Taiwan, R.O.C.
Chang WC; School of Dentistry, National Defense Medical Center, Taipei, Taiwan, R.O.C.; Department of Oral and Maxillofacial Surgery, Tri-Service General Hospital, Taipei, Taiwan, R.O.C.
Cheng JC; School of Dentistry, National Defense Medical Center, Taipei, Taiwan, R.O.C.; Department of Oral and Maxillofacial Surgery, Tri-Service General Hospital, Taipei, Taiwan, R.O.C.
Lin GJ; Department of Biology and Anatomy, National Defense Medical Center, Taipei, Taiwan, R.O.C.
Sytwu HK; Department of Microbiology and Immunology, National Defense Medical Center, Taipei, Taiwan, R.O.C.; National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli County, Taiwan, R.O.C.
Wang YL; Department of Dentistry, Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan, R.O.C.
Chen YW; School of Dentistry, National Defense Medical Center, Taipei, Taiwan, R.O.C.; Department of Oral and Maxillofacial Surgery, Tri-Service General Hospital, Taipei, Taiwan, R.O.C.
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Źródło :
PloS one [PLoS One] 2020 Jul 17; Vol. 15 (7), pp. e0236101. Date of Electronic Publication: 2020 Jul 17 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Proliferation*
Biomarkers, Tumor/*metabolism
Carcinoma, Squamous Cell/*pathology
Histone Demethylases/*metabolism
Mouth Neoplasms/*pathology
Repressor Proteins/*metabolism
Silybin/*pharmacology
Trans-Activators/*metabolism
Animals ; Antineoplastic Agents, Phytogenic/pharmacology ; Apoptosis ; Biomarkers, Tumor/genetics ; Carcinoma, Squamous Cell/drug therapy ; Carcinoma, Squamous Cell/metabolism ; Female ; Gene Expression Regulation, Neoplastic ; Histone Demethylases/genetics ; Humans ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Mouth Neoplasms/drug therapy ; Mouth Neoplasms/metabolism ; Prognosis ; Repressor Proteins/genetics ; Survival Rate ; Trans-Activators/genetics ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Prognostic Value of Histopathological Features and Loss of H3K27me3 Immunolabeling in Anaplastic Meningioma: A Multicenter Retrospective Study.
Autorzy :
Gauchotte G; INSERM U1256, Faculty of Medicine, Université de Lorraine, Vandoeuvre-lès-Nancy.; Department of Pathology, CHRU, Nancy, France.; Centre de Ressources Biologiques, BB-0033-00035 (GG, SL), CHRU, Nancy, France.
Peyre M; Sorbonne Universités, INSERM, CNRS, UMR S 1127, Institut du Cerveau et de la Moelle Épinière, Paris, France.; Department of Neurosurgery, Groupe Hospitalier Pitié Salpêtrière, AP-HP (MP, MK), Paris, France.; Department of Pathology, Hôpital Lariboisière, AP-HP, Paris, France.
Pouget C; INSERM U1256, Faculty of Medicine, Université de Lorraine, Vandoeuvre-lès-Nancy.; Department of Pathology, CHRU, Nancy, France.
Cazals-Hatem D; Department of Pathology, Hôpital Beaujon, AP-HP, Clichy, France.
Polivka M
Rech F; Department of Neurosurgery, CHRU, Nancy, France.; Institut des Neurosciences, INSERM U1051, Montpellier, France.
Varlet P; Department of Neuropathology, Centre Hospitalier Saint-Anne, Paris, France.
Loiseau H; Department of Neurosurgery, CEREPEG, Hôpital Pellegrin Tripode, Bordeaux, France.; EA 7435 - IMOTION University of Bordeaux (HL), Bordeaux.
Lacomme S; Centre de Ressources Biologiques, BB-0033-00035 (GG, SL), CHRU, Nancy, France.
Mokhtari K; Sorbonne Universités, INSERM, CNRS, UMR S 1127, Institut du Cerveau et de la Moelle Épinière, Paris, France.; AP-HP, Department of Neuropathology, Hôpital de la Pitié Salpêtrière, Paris, France.
Kalamarides M; Sorbonne Universités, INSERM, CNRS, UMR S 1127, Institut du Cerveau et de la Moelle Épinière, Paris, France.; Department of Neurosurgery, Groupe Hospitalier Pitié Salpêtrière, AP-HP (MP, MK), Paris, France.
Bielle F; Sorbonne Universités, INSERM, CNRS, UMR S 1127, Institut du Cerveau et de la Moelle Épinière, Paris, France.; AP-HP, Department of Neuropathology, Hôpital de la Pitié Salpêtrière, Paris, France.; SiRIC CURAMUS (Cancer United Research Associating Medicine, University & Society), Site de Recherche Intégrée sur le Cancer IUC, APHP.6, Sorbonne Université (FB), Paris, France.
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Źródło :
Journal of neuropathology and experimental neurology [J Neuropathol Exp Neurol] 2020 Jul 01; Vol. 79 (7), pp. 754-762.
Typ publikacji :
Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Biomarkers, Tumor/*metabolism
Jumonji Domain-Containing Histone Demethylases/*metabolism
Meningeal Neoplasms/*metabolism
Meningeal Neoplasms/*pathology
Meningioma/*metabolism
Meningioma/*pathology
Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/analysis ; Female ; Follow-Up Studies ; Humans ; Jumonji Domain-Containing Histone Demethylases/analysis ; Male ; Meningeal Neoplasms/diagnosis ; Meningioma/diagnosis ; Middle Aged ; Prognosis ; Retrospective Studies ; Survival Rate/trends ; Young Adult
Czasopismo naukowe
Tytuł :
Enhancer-mediated enrichment of interacting JMJD3-DDX21 to ENPP2 locus prevents R-loop formation and promotes transcription.
Autorzy :
Argaud D; Laboratory of Cardiovascular Pathobiology, Quebec Heart and Lung Institute/Research Center, Department of Surgery, Laval University, Quebec G1V-4G5, Canada.
Boulanger MC; Laboratory of Cardiovascular Pathobiology, Quebec Heart and Lung Institute/Research Center, Department of Surgery, Laval University, Quebec G1V-4G5, Canada.
Chignon A; Laboratory of Cardiovascular Pathobiology, Quebec Heart and Lung Institute/Research Center, Department of Surgery, Laval University, Quebec G1V-4G5, Canada.
Mkannez G; Laboratory of Cardiovascular Pathobiology, Quebec Heart and Lung Institute/Research Center, Department of Surgery, Laval University, Quebec G1V-4G5, Canada.
Mathieu P; Laboratory of Cardiovascular Pathobiology, Quebec Heart and Lung Institute/Research Center, Department of Surgery, Laval University, Quebec G1V-4G5, Canada.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2019 Sep 19; Vol. 47 (16), pp. 8424-8438.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DEAD-box RNA Helicases/*genetics
DNA/*genetics
Jumonji Domain-Containing Histone Demethylases/*genetics
Phosphoric Diester Hydrolases/*genetics
RNA, Messenger/*genetics
Transcription, Genetic/*drug effects
CRISPR-Cas Systems ; DEAD-box RNA Helicases/metabolism ; DNA/chemistry ; DNA/metabolism ; Enhancer Elements, Genetic ; Gene Editing/methods ; Gene Expression Regulation ; HEK293 Cells ; Histone Demethylases/genetics ; Histone Demethylases/metabolism ; Histones/genetics ; Histones/metabolism ; Humans ; Inflammation ; Jumonji Domain-Containing Histone Demethylases/metabolism ; Lipopolysaccharides/pharmacology ; Models, Biological ; NF-kappa B/genetics ; NF-kappa B/metabolism ; Nucleic Acid Conformation ; Phosphoric Diester Hydrolases/metabolism ; Protein Binding ; RNA, Messenger/biosynthesis ; RNA, Messenger/chemistry ; Signal Transduction ; Transcription Initiation Site
Czasopismo naukowe
Tytuł :
Vitamin C-dependent lysine demethylase 6 (KDM6)-mediated demethylation promotes a chromatin state that supports the endothelial-to-hematopoietic transition.
Autorzy :
Zhang T; CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou 510530, China.; University of Chinese Academy of Sciences, Beijing 100049, China.; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.; Hefei Institute of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China.; Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, 510005 China.
Huang K; CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou 510530, China.; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.; Hefei Institute of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China.; Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, 510005 China.
Zhu Y; CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou 510530, China.; University of Chinese Academy of Sciences, Beijing 100049, China.; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.
Wang T; CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou 510530, China.; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.
Shan Y; CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou 510530, China.; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.
Long B; Department of Hematology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China.
Li Y; CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou 510530, China.; University of Chinese Academy of Sciences, Beijing 100049, China.; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.
Chen Q; CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou 510530, China.; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.
Wang P; CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou 510530, China.; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.
Zhao S; CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou 510530, China.; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.
Li D; CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou 510530, China.; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.
Wu C; CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou 510530, China.; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.
Kang B; CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou 510530, China.; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.
Gu J; CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou 510530, China.; University of Chinese Academy of Sciences, Beijing 100049, China.; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.
Mai Y; CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou 510530, China.; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.
Wang Q; CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou 510530, China.; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.
Li J; CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou 510530, China.; University of Chinese Academy of Sciences, Beijing 100049, China.; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.
Zhang Y; CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou 510530, China.; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.
Liang Z; CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou 510530, China.; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.
Guo L; CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou 510530, China.; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.
Wu F; CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou 510530, China.; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.
Su S; CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou 510530, China.; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.
Wang J; CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou 510530, China.; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.
Gao M; CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou 510530, China.; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.
Zhong X; CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou 510530, China.; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.
Liao B; CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou 510530, China.; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.; Hefei Institute of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.
Chen J; CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou 510530, China.; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.
Zhang X; CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou 510530, China.; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.
Shu X; CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou 510530, China.; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.
Pei D; CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou 510530, China.; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.
Nie J; CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou 510530, China.; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.; Anhui Province Key Laboratory of Medical Physics and Technology, Center of Medical Physics and Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui 230031, China.; Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei, Anhui 230031, China.
Pan G; CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou 510530, China .; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.; Hefei Institute of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.; Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, 510005 China.; Shandong Medicinal Biotechnology Center, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250012, China.
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2019 Sep 13; Vol. 294 (37), pp. 13657-13670. Date of Electronic Publication: 2019 Jul 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Ascorbic Acid/*metabolism
Hematopoietic Stem Cells/*metabolism
Histone Demethylases/*metabolism
Animals ; Animals, Genetically Modified ; Cell Differentiation/genetics ; Cell Differentiation/physiology ; Chromatin/metabolism ; Chromatin/physiology ; Demethylation ; Endothelial Cells/metabolism ; Histone Demethylases/genetics ; Histones/metabolism ; Humans ; Jumonji Domain-Containing Histone Demethylases/metabolism ; Lysine/metabolism ; Methylation ; Pluripotent Stem Cells/metabolism ; Zebrafish/genetics
Czasopismo naukowe
Tytuł :
Combined inhibition of JAK/STAT pathway and lysine-specific demethylase 1 as a therapeutic strategy in CSF3R/CEBPA mutant acute myeloid leukemia.
Autorzy :
Braun TP; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239.; Division of Hematology and Medical Oncology, Oregon Health & Science University, Portland, OR 97239.
Coblentz C; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239.
Smith BM; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239.
Coleman DJ; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239.
Schonrock Z; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239.
Carratt SA; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239.
Callahan RL; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239.
Maniaci B; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239.
Druker BJ; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239; .; Division of Hematology and Medical Oncology, Oregon Health & Science University, Portland, OR 97239.
Maxson JE; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239; .; Division of Hematology and Medical Oncology, Oregon Health & Science University, Portland, OR 97239.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Jun 16; Vol. 117 (24), pp. 13670-13679. Date of Electronic Publication: 2020 May 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
CCAAT-Enhancer-Binding Proteins/*genetics
Enzyme Inhibitors/*administration & dosage
Histone Demethylases/*antagonists & inhibitors
Janus Kinase 2/*antagonists & inhibitors
Leukemia, Myeloid, Acute/*drug therapy
Receptors, Colony-Stimulating Factor/*genetics
STAT Transcription Factors/*metabolism
Animals ; CCAAT-Enhancer-Binding Proteins/metabolism ; Female ; Histone Demethylases/genetics ; Histone Demethylases/metabolism ; Humans ; Janus Kinase 2/genetics ; Janus Kinase 2/metabolism ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/metabolism ; Mice ; Mice, Inbred BALB C ; Receptors, Colony-Stimulating Factor/metabolism ; STAT Transcription Factors/antagonists & inhibitors ; STAT Transcription Factors/genetics ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Crystal Structure of the LSD1/CoREST Histone Demethylase Bound to Its Nucleosome Substrate.
Autorzy :
Kim SA; Department of Biochemistry and Molecular Biology, Center for Eukaryotic Gene Regulation, The Pennsylvania State University, University Park, PA 16802, USA.
Zhu J; Department of Biochemistry and Molecular Biology, Center for Eukaryotic Gene Regulation, The Pennsylvania State University, University Park, PA 16802, USA.
Yennawar N; Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
Eek P; Department of Biochemistry and Molecular Biology, Center for Eukaryotic Gene Regulation, The Pennsylvania State University, University Park, PA 16802, USA.
Tan S; Department of Biochemistry and Molecular Biology, Center for Eukaryotic Gene Regulation, The Pennsylvania State University, University Park, PA 16802, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 Jun 04; Vol. 78 (5), pp. 903-914.e4. Date of Electronic Publication: 2020 May 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Histone Demethylases/*metabolism
Histone Demethylases/*ultrastructure
Amino Acid Sequence ; Catalytic Domain ; Chromatin/metabolism ; Co-Repressor Proteins/genetics ; Co-Repressor Proteins/metabolism ; Crystallography, X-Ray/methods ; DNA/genetics ; DNA/metabolism ; Histone Demethylases/genetics ; Histones/metabolism ; Humans ; Methylation ; Models, Molecular ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Nucleosomes/chemistry ; Nucleosomes/genetics ; Nucleosomes/metabolism ; Peptides/metabolism ; Protein Binding ; Protein Conformation
Czasopismo naukowe

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