Temat: "Histone Demethylases" - OpacWWW

Skocz do pozycji: 41.

Tytuł:: Next generation phenotyping for diagnosis and phenotype-genotype correlations in Kabuki syndrome.
Autorzy:: Hennocq Q; Imagine Institute, INSERM UMR1163, 75015, Paris, France. .; Service de chirurgie maxillo-faciale et chirurgie plastique, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France. .; Centre de Référence des Malformations Rares de la Face et de la Cavité Buccale MAFACE, Filière Maladies Rares TeteCou, Paris, France. .; Faculté de Médecine, Université de Paris Cité, 75015, Paris, France. .; Laboratoire 'Forme et Croissance du Crâne', Faculté de Médecine, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Université Paris Cité, Paris, France. .; Hôpital Necker-Enfants Malades, 149 rue de Sèvres, 75015, Paris, France. .
Willems M; Département de Génétique Médicale, Maladies Rares et Médecine Personnalisée, Génétique clinique, CHU Montpellier, Centre de référence anomalies du développement SOOR, INSERM U1183, Montpellier University, Montpellier, France.
Amiel J; Imagine Institute, INSERM UMR1163, 75015, Paris, France.; Faculté de Médecine, Université de Paris Cité, 75015, Paris, France.; Service de médecine génomique des maladies rares, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France.
Arpin S; Service de Génétique, CHU Tours, UMR 1253, iBrain, Université de Tours, Inserm, Tours, France.
Attie-Bitach T; Imagine Institute, INSERM UMR1163, 75015, Paris, France.; Faculté de Médecine, Université de Paris Cité, 75015, Paris, France.; Service de médecine génomique des maladies rares, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France.
Bongibault T; Imagine Institute, INSERM UMR1163, 75015, Paris, France.; Laboratoire 'Forme et Croissance du Crâne', Faculté de Médecine, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Université Paris Cité, Paris, France.
Bouygues T; Imagine Institute, INSERM UMR1163, 75015, Paris, France.; Laboratoire 'Forme et Croissance du Crâne', Faculté de Médecine, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Université Paris Cité, Paris, France.
Cormier-Daire V; Imagine Institute, INSERM UMR1163, 75015, Paris, France.; Faculté de Médecine, Université de Paris Cité, 75015, Paris, France.; Service de médecine génomique des maladies rares, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France.
Corre P; Nantes Université, CHU Nantes, Service de chirurgie maxillo-faciale et stomatologie, 44000, Nantes, France.; Nantes Université, Oniris, UnivAngers, CHU Nantes, INSERM, Regenerative Medicine and Skeleton, RMeS, UMR 1229, 44000, Nantes, France.
Dieterich K; Univ. Grenoble Alpes, Inserm, U1209, IAB, CHU Grenoble Alpes, 38000, Grenoble, France.
Douillet M; Imagine Institute, INSERM UMR1163, 75015, Paris, France.
Feydy J; HeKA team, INRIA, 75012, Paris, France.
Galliani E; Service de chirurgie maxillo-faciale et chirurgie plastique, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France.; Centre de Référence des Malformations Rares de la Face et de la Cavité Buccale MAFACE, Filière Maladies Rares TeteCou, Paris, France.; Faculté de Médecine, Université de Paris Cité, 75015, Paris, France.
Giuliano F; MEDISYN Genetics, Lausanne, Switzerland.
Lyonnet S; Imagine Institute, INSERM UMR1163, 75015, Paris, France.; Faculté de Médecine, Université de Paris Cité, 75015, Paris, France.; Service de médecine génomique des maladies rares, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France.
Picard A; Service de chirurgie maxillo-faciale et chirurgie plastique, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France.; Centre de Référence des Malformations Rares de la Face et de la Cavité Buccale MAFACE, Filière Maladies Rares TeteCou, Paris, France.; Faculté de Médecine, Université de Paris Cité, 75015, Paris, France.
Porntaveetus T; Center of Excellence in Genomics and Precision Dentistry, Department of Physiology, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.
Rio M; Imagine Institute, INSERM UMR1163, 75015, Paris, France.; Faculté de Médecine, Université de Paris Cité, 75015, Paris, France.; Service de médecine génomique des maladies rares, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France.
Rouxel F; Département de Génétique Médicale, Maladies Rares et Médecine Personnalisée, Génétique clinique, CHU Montpellier, Centre de référence anomalies du développement SOOR, INSERM U1183, Montpellier University, Montpellier, France.
Shotelersuk V; Center of Excellence for Medical Genomics, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Toutain A; Service de Génétique, CHU Tours, UMR 1253, iBrain, Université de Tours, Inserm, Tours, France.
Yauy K; Département de Génétique Médicale, Maladies Rares et Médecine Personnalisée, Génétique clinique, CHU Montpellier, Centre de référence anomalies du développement SOOR, INSERM U1183, Montpellier University, Montpellier, France.
Geneviève D; Département de Génétique Médicale, Maladies Rares et Médecine Personnalisée, Génétique clinique, CHU Montpellier, Centre de référence anomalies du développement SOOR, INSERM U1183, Montpellier University, Montpellier, France.
Khonsari RH; Imagine Institute, INSERM UMR1163, 75015, Paris, France.; Service de chirurgie maxillo-faciale et chirurgie plastique, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France.; Centre de Référence des Malformations Rares de la Face et de la Cavité Buccale MAFACE, Filière Maladies Rares TeteCou, Paris, France.; Faculté de Médecine, Université de Paris Cité, 75015, Paris, France.; Laboratoire 'Forme et Croissance du Crâne', Faculté de Médecine, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Université Paris Cité, Paris, France.
Garcelon N; Imagine Institute, INSERM UMR1163, 75015, Paris, France.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2024 Jan 28; Vol. 14 (1), pp. 2330. Date of Electronic Publication: 2024 Jan 28.
Typ publikacji:: Journal Article
MeSH Terms:: Artificial Intelligence*
Hematologic Diseases*/diagnosis
Hematologic Diseases*/genetics
Abnormalities, Multiple*
Vestibular Diseases*
Face/*abnormalities
Humans ; Mutation ; Retrospective Studies ; Phenotype ; Histone Demethylases/genetics ; Genotype
SCR Disease Name:: Kabuki syndrome

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Skocz do pozycji: 42.

Tytuł:: Lysine-Specific Demethylase 1 Inhibitors: A Comprehensive Review Utilizing Computer-Aided Drug Design Technologies.
Autorzy:: Han D; School of Medical Engineering, Xinxiang Medical University, Xinxiang 453003, China.; Henan International Joint Laboratory of Neural Information Analysis and Drug Intelligent Design, Xinxiang 453003, China.; Xinxiang Key Laboratory of Biomedical Information Research, Xinxiang 453003, China.
Lu J; School of Medical Engineering, Xinxiang Medical University, Xinxiang 453003, China.; Henan International Joint Laboratory of Neural Information Analysis and Drug Intelligent Design, Xinxiang 453003, China.; Xinxiang Key Laboratory of Biomedical Information Research, Xinxiang 453003, China.
Fan B; School of Medical Engineering, Xinxiang Medical University, Xinxiang 453003, China.; Henan International Joint Laboratory of Neural Information Analysis and Drug Intelligent Design, Xinxiang 453003, China.; Xinxiang Key Laboratory of Biomedical Information Research, Xinxiang 453003, China.
Lu W; School of Medical Engineering, Xinxiang Medical University, Xinxiang 453003, China.; Henan International Joint Laboratory of Neural Information Analysis and Drug Intelligent Design, Xinxiang 453003, China.; Xinxiang Key Laboratory of Biomedical Information Research, Xinxiang 453003, China.
Xue Y; School of Medical Engineering, Xinxiang Medical University, Xinxiang 453003, China.; Henan International Joint Laboratory of Neural Information Analysis and Drug Intelligent Design, Xinxiang 453003, China.; Xinxiang Key Laboratory of Biomedical Information Research, Xinxiang 453003, China.
Wang M; School of Medical Engineering, Xinxiang Medical University, Xinxiang 453003, China.; Henan International Joint Laboratory of Neural Information Analysis and Drug Intelligent Design, Xinxiang 453003, China.; Xinxiang Key Laboratory of Biomedical Information Research, Xinxiang 453003, China.
Liu T; School of Medical Engineering, Xinxiang Medical University, Xinxiang 453003, China.; Henan International Joint Laboratory of Neural Information Analysis and Drug Intelligent Design, Xinxiang 453003, China.; Xinxiang Key Laboratory of Biomedical Information Research, Xinxiang 453003, China.
Cui S; School of Forensic, Xinxiang Medical University, Xinxiang 453003, China.
Gao Q; School of Pharmacy, Xinxiang Medical University, Xinxiang 453003, China.
Duan Y; School of Pharmacy, Xinxiang Medical University, Xinxiang 453003, China.
Xu Y; School of Medical Engineering, Xinxiang Medical University, Xinxiang 453003, China.; Henan International Joint Laboratory of Neural Information Analysis and Drug Intelligent Design, Xinxiang 453003, China.; Xinxiang Key Laboratory of Biomedical Information Research, Xinxiang 453003, China.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2024 Jan 22; Vol. 29 (2). Date of Electronic Publication: 2024 Jan 22.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Enzyme Inhibitors*/pharmacology
Enzyme Inhibitors*/chemistry
Biological Products*
Lysine ; Molecular Docking Simulation ; Artificial Intelligence ; Drug Design ; Histone Demethylases/metabolism ; Structure-Activity Relationship

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Skocz do pozycji: 43.

Tytuł:: MicroRNA-93-5p regulates odontogenic differentiation and dentin formation via KDM6B.
Autorzy:: Wu S; State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, No. 14, Section 3, Renmin South Road, Chengdu, 610041, Sichuan, China.
Xu X; State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, No. 14, Section 3, Renmin South Road, Chengdu, 610041, Sichuan, China.
Gao S; State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, No. 14, Section 3, Renmin South Road, Chengdu, 610041, Sichuan, China.
Huo S; State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, No. 14, Section 3, Renmin South Road, Chengdu, 610041, Sichuan, China.
Wan M; State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, No. 14, Section 3, Renmin South Road, Chengdu, 610041, Sichuan, China.
Zhou X; State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, No. 14, Section 3, Renmin South Road, Chengdu, 610041, Sichuan, China.
Zhou X; State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, No. 14, Section 3, Renmin South Road, Chengdu, 610041, Sichuan, China.
Zheng L; State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, No. 14, Section 3, Renmin South Road, Chengdu, 610041, Sichuan, China. .
Zhou Y; State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, No. 14, Section 3, Renmin South Road, Chengdu, 610041, Sichuan, China. .; Pokaż więcej
Źródło:: Journal of translational medicine [J Transl Med] 2024 Jan 13; Vol. 22 (1), pp. 54. Date of Electronic Publication: 2024 Jan 13.
Typ publikacji:: Journal Article
MeSH Terms:: Histones*/metabolism
MicroRNAs*/genetics
MicroRNAs*/metabolism
Humans ; Rats ; Animals ; Stem Cells ; Cell Differentiation/genetics ; Dentin ; Cells, Cultured ; Jumonji Domain-Containing Histone Demethylases/genetics

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Skocz do pozycji: 44.

Tytuł:: Cyclin B2 impairs the p53 signaling in nasopharyngeal carcinoma.
Autorzy:: Liu Q; Department of Otolaryngology, Qingdao Municipal Hospital, NO. 1, Shibei District, Jiaozhou Road, 266011, Qingdao, Shandong, P.R. China.
Yuan Y; Department of Otolaryngology, Qingdao Municipal Hospital, NO. 1, Shibei District, Jiaozhou Road, 266011, Qingdao, Shandong, P.R. China.
Shang X; Department of Otolaryngology, Qingdao Municipal Hospital, NO. 1, Shibei District, Jiaozhou Road, 266011, Qingdao, Shandong, P.R. China.
Xin L; Department of Otolaryngology, Qingdao Municipal Hospital, NO. 1, Shibei District, Jiaozhou Road, 266011, Qingdao, Shandong, P.R. China. .; Pokaż więcej
Źródło:: BMC cancer [BMC Cancer] 2024 Jan 02; Vol. 24 (1), pp. 25. Date of Electronic Publication: 2024 Jan 02.
Typ publikacji:: Journal Article
MeSH Terms:: Cyclin B2*/genetics
Cyclin B2*/metabolism
Nasopharyngeal Carcinoma*/genetics
Nasopharyngeal Carcinoma*/pathology
Nasopharyngeal Neoplasms*/genetics
Nasopharyngeal Neoplasms*/pathology
Tumor Suppressor Protein p53*/genetics
Tumor Suppressor Protein p53*/metabolism
Humans ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; Epithelial-Mesenchymal Transition/genetics ; Gene Expression Regulation, Neoplastic ; Jumonji Domain-Containing Histone Demethylases/metabolism ; Signal Transduction/genetics

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Skocz do pozycji: 45.

Tytuł:: Proliferation, migration and phenotypic transformation of VSMC induced via Hcy related to up-expression of WWP2 and p-STAT3.
Autorzy:: Wang X; Department of Pathophysiology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia, P.R. China.; Key Laboratory of Metabolic Cardiovascular Diseases Research of National Health Commission, Ningxia Key Laboratory of Vascular Injury and Repair Research, Yinchuan, Ningxia, P.R. China.
Gui N; Department of Pathophysiology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia, P.R. China.
Ma X; Key Laboratory of Metabolic Cardiovascular Diseases Research of National Health Commission, Ningxia Key Laboratory of Vascular Injury and Repair Research, Yinchuan, Ningxia, P.R. China.
Zeng Y; Key Laboratory of Metabolic Cardiovascular Diseases Research of National Health Commission, Ningxia Key Laboratory of Vascular Injury and Repair Research, Yinchuan, Ningxia, P.R. China.
Mo T; Department of Pathophysiology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia, P.R. China.
Zhang M; Department of Pathophysiology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia, P.R. China.; Key Laboratory of Metabolic Cardiovascular Diseases Research of National Health Commission, Ningxia Key Laboratory of Vascular Injury and Repair Research, Yinchuan, Ningxia, P.R. China.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2024 Jan 02; Vol. 19 (1), pp. e0296359. Date of Electronic Publication: 2024 Jan 02 (Print Publication: 2024).
Typ publikacji:: Journal Article
MeSH Terms:: Muscle, Smooth, Vascular*/metabolism
Muscle, Smooth, Vascular*/pathology
Atherosclerosis*/metabolism
Atherosclerosis*/pathology
Homocystine*/metabolism
Ubiquitin-Protein Ligases*/metabolism
Male ; Animals ; Mice ; STAT3 Transcription Factor/metabolism ; Apolipoproteins E/metabolism ; Signal Transduction ; Aorta/cytology ; Cell Movement ; Sirtuin 1/metabolism ; Phosphorylation ; Histone Demethylases/metabolism

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Skocz do pozycji: 46.

Tytuł:: Transcriptome-wide map of N6-methyladenosine (m6A) profiling in coronary artery disease (CAD) with clopidogrel resistance.
Autorzy:: Yu R; Department of Cardiology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, People's Republic of China.; Key Laboratory of Precision Medicine for Atherosclerotic Diseases of Zhejiang Province, Ningbo, People's Republic of China.
Yu Q; Department of Traditional Chinese Internal Medicine, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, People's Republic of China.
Li Z; Department of Cardiology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, People's Republic of China.; Key Laboratory of Precision Medicine for Atherosclerotic Diseases of Zhejiang Province, Ningbo, People's Republic of China.
Li J; Department of Cardiology, Yuyao People's Hospital of Zhejiang Province, Yuyao, Zhejiang, People's Republic of China.
Yang J; Department of Geriatrics, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, People's Republic of China.
Hu Y; Department of Cardiology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, People's Republic of China.; Key Laboratory of Precision Medicine for Atherosclerotic Diseases of Zhejiang Province, Ningbo, People's Republic of China.
Zheng N; Department of Cardiology, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo, Zhejiang, People's Republic of China.
Li X; Department of Geriatrics, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, People's Republic of China.
Song Y; Department of Cardiology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, People's Republic of China.
Li J; Department of Cardiology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, People's Republic of China.
Chen X; Department of Cardiology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, People's Republic of China. .; Key Laboratory of Precision Medicine for Atherosclerotic Diseases of Zhejiang Province, Ningbo, People's Republic of China. .
Du W; Department of Cardiology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, People's Republic of China. .; Key Laboratory of Precision Medicine for Atherosclerotic Diseases of Zhejiang Province, Ningbo, People's Republic of China. .
Su J; Department of Cardiology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, People's Republic of China. .; Key Laboratory of Precision Medicine for Atherosclerotic Diseases of Zhejiang Province, Ningbo, People's Republic of China. .; Pokaż więcej
Źródło:: Clinical epigenetics [Clin Epigenetics] 2023 Dec 15; Vol. 15 (1), pp. 194. Date of Electronic Publication: 2023 Dec 15.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Coronary Artery Disease*/drug therapy
Coronary Artery Disease*/genetics
RNA, Long Noncoding*/genetics
Humans ; Clopidogrel/pharmacology ; RNA, Circular/genetics ; Transcriptome ; DNA Methylation ; Adenosine/pharmacology ; RNA, Messenger/genetics ; Jumonji Domain-Containing Histone Demethylases ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO

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Tytuł:: A comprehensive AI-driven analysis of large-scale omic datasets reveals novel dual-purpose targets for the treatment of cancer and aging.
Autorzy:: Pun FW; Insilico Medicine Hong Kong Ltd., Hong Kong, China.
Leung GHD; Insilico Medicine Hong Kong Ltd., Hong Kong, China.
Leung HW; Insilico Medicine Hong Kong Ltd., Hong Kong, China.
Rice J; Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway.
Schmauck-Medina T; Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway.
Lautrup S; Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway.
Long X; Insilico Medicine Hong Kong Ltd., Hong Kong, China.
Liu BHM; Insilico Medicine Hong Kong Ltd., Hong Kong, China.
Wong CW; Insilico Medicine Hong Kong Ltd., Hong Kong, China.
Ozerov IV; Insilico Medicine Hong Kong Ltd., Hong Kong, China.
Aliper A; Insilico Medicine AI Ltd., Masdar City, United Arab Emirates.
Ren F; Insilico Medicine Shanghai Ltd., Shanghai, China.
Rosenberg AJ; Department of Medicine, Section of Hematology and Oncology, University of Chicago, Chicago, Illinois, USA.
Agrawal N; Department of Surgery, University of Chicago, Chicago, Illinois, USA.
Izumchenko E; Department of Medicine, Section of Hematology and Oncology, University of Chicago, Chicago, Illinois, USA.
Fang EF; Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway.; The Norwegian Centre On Healthy Ageing (NO-Age), Oslo, Norway.
Zhavoronkov A; Insilico Medicine Hong Kong Ltd., Hong Kong, China.; Insilico Medicine AI Ltd., Masdar City, United Arab Emirates.; Buck Institute for Research on Aging, Novato, California, USA.; Pokaż więcej
Źródło:: Aging cell [Aging Cell] 2023 Dec; Vol. 22 (12), pp. e14017. Date of Electronic Publication: 2023 Oct 27.
Typ publikacji:: Journal Article
MeSH Terms:: Caenorhabditis elegans Proteins*/metabolism
Neoplasms*/drug therapy
Neoplasms*/genetics
Animals ; Humans ; Aging/genetics ; Longevity/genetics ; Caenorhabditis elegans/metabolism ; Artificial Intelligence ; Histone Demethylases/metabolism

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Skocz do pozycji: 48.

Tytuł:: Exploration of Morphological Features of Clear Cell Renal Cell Carcinoma With PBRM1 , SETD2 , BAP1 , or KDM5C Mutations.
Autorzy:: Liu Y; Department of Pathology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Li Y; The First Clinical College, China Medical University, Shenyang, China.
Xu H; Department of Pathology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhou L; Department of Pathology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yang X; Department of Pathology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Wang C; Department of Pathology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Pokaż więcej
Źródło:: International journal of surgical pathology [Int J Surg Pathol] 2023 Dec; Vol. 31 (8), pp. 1485-1494. Date of Electronic Publication: 2023 Mar 13.
Typ publikacji:: Journal Article
MeSH Terms:: Carcinoma, Renal Cell*/pathology
Kidney Neoplasms*/genetics
Kidney Neoplasms*/pathology
Humans ; Tumor Suppressor Proteins/genetics ; Mutation ; DNA-Binding Proteins/genetics ; Transcription Factors/genetics ; Ubiquitin Thiolesterase/genetics ; Histone Demethylases/genetics

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Tytuł:: Echinococcus granulosus cyst fluid inhibits KDM6B-mediated demethylation of trimethylated histone H3 lysine 27 and interleukin-1β production in macrophages.
Autorzy:: Lin R; NHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases, Shihezi University School of Medicine, Shihezi, Xinjiang, China.; Key Laboratory of Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine, Shihezi, Xinjiang, China.
Wang X; NHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases, Shihezi University School of Medicine, Shihezi, Xinjiang, China.; Key Laboratory of Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine, Shihezi, Xinjiang, China.
Ni C; NHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases, Shihezi University School of Medicine, Shihezi, Xinjiang, China.; Key Laboratory of Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine, Shihezi, Xinjiang, China.
Fu C; NHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases, Shihezi University School of Medicine, Shihezi, Xinjiang, China.; Key Laboratory of Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine, Shihezi, Xinjiang, China.
Yang C; NHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases, Shihezi University School of Medicine, Shihezi, Xinjiang, China.; Key Laboratory of Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine, Shihezi, Xinjiang, China.
Dong D
Wu X; NHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases, Shihezi University School of Medicine, Shihezi, Xinjiang, China.; Key Laboratory of Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine, Shihezi, Xinjiang, China.
Chen X; NHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases, Shihezi University School of Medicine, Shihezi, Xinjiang, China.; Key Laboratory of Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine, Shihezi, Xinjiang, China.
Wang L; NHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases, Shihezi University School of Medicine, Shihezi, Xinjiang, China. lh_.; Key Laboratory of Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine, Shihezi, Xinjiang, China. lh_.
Hou J; NHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases, Shihezi University School of Medicine, Shihezi, Xinjiang, China. .; Key Laboratory of Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine, Shihezi, Xinjiang, China. .; Pokaż więcej
Źródło:: Parasites & vectors [Parasit Vectors] 2023 Nov 16; Vol. 16 (1), pp. 422. Date of Electronic Publication: 2023 Nov 16.
Typ publikacji:: Journal Article
MeSH Terms:: Echinococcus granulosus*/metabolism
Histones*/metabolism
Animals ; Child ; Humans ; Mice ; Cyst Fluid/metabolism ; Demethylation ; Interleukin-1beta/genetics ; Interleukin-1beta/metabolism ; Jumonji Domain-Containing Histone Demethylases/genetics ; Lysine/metabolism ; Lysine/pharmacology ; Macrophages ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Reactive Oxygen Species/metabolism

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Tytuł:: A rare presentation of childhood interstitial lung disease attributed to KDM3B gene mutation: a case report.
Autorzy:: Benslimane Z; General Pediatrics Department, Al Qassimi Women and Children Hospital, Sharjah, United Arab Emirates.
Yavuz S; Pediatric Pulmonology Department, Al Qassimi Women and Children Hospital, Sharjah, United Arab Emirates.
Francis N; Pediatric Pulmonology Department, Al Qassimi Women and Children Hospital, Sharjah, United Arab Emirates.; Pokaż więcej
Źródło:: The Pan African medical journal [Pan Afr Med J] 2023 Nov 13; Vol. 46, pp. 84. Date of Electronic Publication: 2023 Nov 13 (Print Publication: 2023).
Typ publikacji:: Case Reports
MeSH Terms:: Hypertension, Pulmonary*
Lung Diseases, Interstitial*/diagnosis
Lung Diseases, Interstitial*/genetics
Child ; Male ; Humans ; Mutation ; Phenotype ; Genotype ; Jumonji Domain-Containing Histone Demethylases/genetics

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Tytuł:: Inhibition of UTX/KDM6A improves recovery of spinal cord injury by attenuating BSCB permeability and macrophage infiltration through the MLCK/p-MLC pathway.
Autorzy:: Xie Y; Department of Spine Surgery and Orthopaedics, Xiangya Hospital, Central South University, Changsha, China.; Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Changsha, China.; Hunan Engineering Research Center of Sports and Health, Changsha, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
Luo Z; Department of Spine Surgery and Orthopaedics, Xiangya Hospital, Central South University, Changsha, China.; Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Changsha, China.; Hunan Engineering Research Center of Sports and Health, Changsha, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
Peng W; Department of Spine Surgery and Orthopaedics, Xiangya Hospital, Central South University, Changsha, China.; Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Changsha, China.; Hunan Engineering Research Center of Sports and Health, Changsha, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
Liu Y; Department of Spine Surgery and Orthopaedics, Xiangya Hospital, Central South University, Changsha, China.; Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Changsha, China.; Hunan Engineering Research Center of Sports and Health, Changsha, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
Yuan F; Department of Spine Surgery and Orthopaedics, Xiangya Hospital, Central South University, Changsha, China.; Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Changsha, China.; Hunan Engineering Research Center of Sports and Health, Changsha, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
Xu J; Department of Spine Surgery and Orthopaedics, Xiangya Hospital, Central South University, Changsha, China.; Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Changsha, China.; Hunan Engineering Research Center of Sports and Health, Changsha, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
Sun Y; Department of Spine Surgery and Orthopaedics, Xiangya Hospital, Central South University, Changsha, China.; Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Changsha, China.; Hunan Engineering Research Center of Sports and Health, Changsha, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
Lu H; Department of Sports Medicine, Xiangya Hospital, Central South University, Changsha, China.; Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Changsha, China.; Hunan Engineering Research Center of Sports and Health, Changsha, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
Wu T; Department of Spine Surgery and Orthopaedics, Xiangya Hospital, Central South University, Changsha, China. .; Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Changsha, China. .; Hunan Engineering Research Center of Sports and Health, Changsha, China. .; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China. .
Jiang L; Department of Spine Surgery and Orthopaedics, Xiangya Hospital, Central South University, Changsha, China. .; Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Changsha, China. .; Hunan Engineering Research Center of Sports and Health, Changsha, China. .; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China. .
Hu J; Department of Spine Surgery and Orthopaedics, Xiangya Hospital, Central South University, Changsha, China. .; Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Changsha, China. .; Hunan Engineering Research Center of Sports and Health, Changsha, China. .; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China. .; Pokaż więcej
Źródło:: Journal of neuroinflammation [J Neuroinflammation] 2023 Nov 11; Vol. 20 (1), pp. 259. Date of Electronic Publication: 2023 Nov 11.
Typ publikacji:: Journal Article
MeSH Terms:: Myosin Light Chains*/metabolism
Spinal Cord Injuries*/metabolism
Animals ; Mice ; Rats ; Blood-Brain Barrier/metabolism ; Endothelial Cells/metabolism ; Histone Demethylases/genetics ; Myosin-Light-Chain Kinase/metabolism ; Permeability ; Phosphorylation ; Rats, Sprague-Dawley ; Spinal Cord/metabolism

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Tytuł:: Ipsilateral synchronous papillary renal neoplasm with reverse polarity and urothelial carcinoma in a renal transplant recipient: a rare case report with molecular analysis and literature review.
Autorzy:: Li D; Department of Pathology, the Affiliated Tai'an City Central Hospital of Qingdao University, Tai'an, 271000, China.
Liu F; Department of Urology, the Affiliated Tai'an City Central Hospital of Qingdao University, Tai'an, 271000, China.
Chen Y; Department of Rehabilitation, the Affiliated Tai'an City Central Hospital of Qingdao University, Tai'an, 271000, China.
Li P; Department of Pathology, the Affiliated Tai'an City Central Hospital of Qingdao University, Tai'an, 271000, China.
Liu Y; Department of Hematology, the Affiliated Tai'an City Central Hospital of Qingdao University, Tai'an, 271000, China.
Pang Y; Department of Pathology, the Affiliated Tai'an City Central Hospital of Qingdao University, Tai'an, 271000, China. .; Pokaż więcej
Źródło:: Diagnostic pathology [Diagn Pathol] 2023 Nov 03; Vol. 18 (1), pp. 120. Date of Electronic Publication: 2023 Nov 03.
Typ publikacji:: Case Reports; Review; Journal Article
MeSH Terms:: Carcinoma, Renal Cell*/pathology
Carcinoma, Transitional Cell*/diagnosis
Carcinoma, Transitional Cell*/genetics
Carcinoma, Transitional Cell*/pathology
Kidney Neoplasms*/genetics
Kidney Neoplasms*/pathology
Kidney Transplantation*/adverse effects
Neoplasms, Multiple Primary*/genetics
Neoplasms, Multiple Primary*/pathology
Urinary Bladder Neoplasms*/genetics
Aged ; Female ; Humans ; Histone Demethylases ; Kidney/pathology ; Proto-Oncogene Proteins p21(ras)

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Skocz do pozycji: 53.

Tytuł:: The Epigenetic Controller Lysine-Specific Demethylase 1 (LSD1) Regulates the Outcome of Hepatitis C Viral Infection.
Autorzy:: Papadopoulou G; Molecular Virology Laboratory, Hellenic Pasteur Institute, 11521 Athens, Greece.; Division of Animal and Human Physiology, Department of Biology, National and Kapodistrian University of Athens, 15784 Athens, Greece.
Petroulia S; Molecular Virology Laboratory, Hellenic Pasteur Institute, 11521 Athens, Greece.
Karamichali E; Molecular Virology Laboratory, Hellenic Pasteur Institute, 11521 Athens, Greece.
Dimitriadis A; Molecular Biology and Immunobiotechnology Laboratory, Hellenic Pasteur Institute, 11521 Athens, Greece.
Marousis D; Molecular Virology Laboratory, Hellenic Pasteur Institute, 11521 Athens, Greece.
Ioannidou E; Molecular Virology Laboratory, Hellenic Pasteur Institute, 11521 Athens, Greece.
Papazafiri P; Division of Animal and Human Physiology, Department of Biology, National and Kapodistrian University of Athens, 15784 Athens, Greece.
Koskinas J; 2nd Department of Internal Medicine, Medical School of Athens, Hippokration General Hospital, 11521 Athens, Greece.
Foka P; Molecular Virology Laboratory, Hellenic Pasteur Institute, 11521 Athens, Greece.
Georgopoulou U; Molecular Virology Laboratory, Hellenic Pasteur Institute, 11521 Athens, Greece.; Pokaż więcej
Źródło:: Cells [Cells] 2023 Nov 03; Vol. 12 (21). Date of Electronic Publication: 2023 Nov 03.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Hepacivirus*/physiology
Hepatitis C*/genetics
Humans ; Lysine/metabolism ; Histone Demethylases/metabolism ; Epigenesis, Genetic ; Membrane Proteins/metabolism ; RNA-Binding Proteins/metabolism

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Tytuł:: JIB-04, a Pan-Inhibitor of Histone Demethylases, Targets Histone-Lysine-Demethylase-Dependent AKT Pathway, Leading to Cell Cycle Arrest and Inhibition of Cancer Stem-Like Cell Properties in Hepatocellular Carcinoma Cells.
Autorzy:: Lee J; Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University, Seoul 120-749, Korea.; BK21 Yonsei Education & Research Center for Biosystems, Yonsei University, Seoul 120-749, Korea.
Kim JS; Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University, Seoul 120-749, Korea.; BK21 Yonsei Education & Research Center for Biosystems, Yonsei University, Seoul 120-749, Korea.
Cho HI; Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University, Seoul 120-749, Korea.; BK21 Yonsei Education & Research Center for Biosystems, Yonsei University, Seoul 120-749, Korea.
Jo SR; Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University, Seoul 120-749, Korea.; BK21 Yonsei Education & Research Center for Biosystems, Yonsei University, Seoul 120-749, Korea.
Jang YK; Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University, Seoul 120-749, Korea.; BK21 Yonsei Education & Research Center for Biosystems, Yonsei University, Seoul 120-749, Korea.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2022 Jul 11; Vol. 23 (14). Date of Electronic Publication: 2022 Jul 11.
Typ publikacji:: Journal Article
MeSH Terms:: Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/therapeutic use
Carcinoma, Hepatocellular*/drug therapy
Carcinoma, Hepatocellular*/metabolism
Cell Cycle Checkpoints*/drug effects
Cell Cycle Checkpoints*/physiology
Histone Demethylases*/antagonists & inhibitors
Histone Demethylases*/metabolism
Histone Demethylases*/pharmacology
Jumonji Domain-Containing Histone Demethylases*/pharmacology
Jumonji Domain-Containing Histone Demethylases*/therapeutic use
Liver Neoplasms*/drug therapy
Liver Neoplasms*/metabolism
Aminopyridines ; Cell Line, Tumor ; Histones/metabolism ; Humans ; Hydrazones ; Lysine/metabolism ; Neoplasm Recurrence, Local/metabolism ; Neoplastic Stem Cells/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism

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Tytuł:: The Functions of the Demethylase JMJD3 in Cancer.
Autorzy:: Sanchez A; Department of Oncogenetics, Centre Jean Perrin, CBRV, 63001 Clermont-Ferrand, France.; INSERM U 1240 Molecular Imagery and Theranostic Strategies (IMoST), 63005 Clermont-Ferrand, France.
Houfaf Khoufaf FZ; Department of Oncogenetics, Centre Jean Perrin, CBRV, 63001 Clermont-Ferrand, France.; INSERM U 1240 Molecular Imagery and Theranostic Strategies (IMoST), 63005 Clermont-Ferrand, France.
Idrissou M; Department of Oncogenetics, Centre Jean Perrin, CBRV, 63001 Clermont-Ferrand, France.; INSERM U 1240 Molecular Imagery and Theranostic Strategies (IMoST), 63005 Clermont-Ferrand, France.
Penault-Llorca F; INSERM U 1240 Molecular Imagery and Theranostic Strategies (IMoST), 63005 Clermont-Ferrand, France.; Department of Biopathology, Centre Jean Perrin, 63011 Clermont-Ferrand, France.
Bignon YJ; Department of Oncogenetics, Centre Jean Perrin, CBRV, 63001 Clermont-Ferrand, France.; INSERM U 1240 Molecular Imagery and Theranostic Strategies (IMoST), 63005 Clermont-Ferrand, France.
Guy L; INSERM U 1240 Molecular Imagery and Theranostic Strategies (IMoST), 63005 Clermont-Ferrand, France.; Department of Urology, Gabriel Montpied Hospital, 63000 Clermont-Ferrand, France.
Bernard-Gallon D; Department of Oncogenetics, Centre Jean Perrin, CBRV, 63001 Clermont-Ferrand, France.; INSERM U 1240 Molecular Imagery and Theranostic Strategies (IMoST), 63005 Clermont-Ferrand, France.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Jan 19; Vol. 22 (2). Date of Electronic Publication: 2021 Jan 19.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Jumonji Domain-Containing Histone Demethylases/*physiology
Neoplasms/*genetics
Animals ; DNA Methylation/genetics ; Enhancer of Zeste Homolog 2 Protein/physiology ; Epigenesis, Genetic/genetics ; Female ; Histone Demethylases/physiology ; Histones/metabolism ; Humans ; Male ; Neoplasms/metabolism ; Neoplasms/pathology

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Skocz do pozycji: 56.

Tytuł:: Dysregulation of the histone demethylase KDM6B in alcohol dependence is associated with epigenetic regulation of inflammatory signaling pathways.
Autorzy:: Johnstone AL; Center for Therapeutic Innovation, University of Miami Miller School of Medicine, Miami, Florida, USA.; Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, Florida, USA.; Division of Product Development, EpiCypher, Inc, Durham, North Carolina, USA.
Andrade NS; Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, Florida, USA.
Barbier E; Department of Clinical and Experimental Medicine, Division of Cell Biology, Faculty of Health Sciences, Linköping University, Linköping, Sweden.
Khomtchouk BB; Center for Therapeutic Innovation, University of Miami Miller School of Medicine, Miami, Florida, USA.; Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, Florida, USA.; Department of Medicine, Section of Computational Biomedicine and Biomedical Data Science, Institute for Genomics and Systems Biology, University of Chicago, Chicago, IL, USA.
Rienas CA; Center for Therapeutic Innovation, University of Miami Miller School of Medicine, Miami, Florida, USA.; Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, Florida, USA.
Lowe K; Center for Therapeutic Innovation, University of Miami Miller School of Medicine, Miami, Florida, USA.; Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, Florida, USA.
Van Booven DJ; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA.
Domi E; Department of Clinical and Experimental Medicine, Division of Cell Biology, Faculty of Health Sciences, Linköping University, Linköping, Sweden.
Esanov R; Center for Therapeutic Innovation, University of Miami Miller School of Medicine, Miami, Florida, USA.; Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, Florida, USA.
Vilca S; Center for Therapeutic Innovation, University of Miami Miller School of Medicine, Miami, Florida, USA.; Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, Florida, USA.
Tapocik JD; Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA.
Rodriguez K; Division of Product Development, EpiCypher, Inc, Durham, North Carolina, USA.
Maryanski D; Division of Product Development, EpiCypher, Inc, Durham, North Carolina, USA.
Keogh MC; Division of Product Development, EpiCypher, Inc, Durham, North Carolina, USA.
Meinhardt MW; Department of Psychopharmacology, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany.
Sommer WH; Department of Psychopharmacology, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany.
Heilig M; Department of Clinical and Experimental Medicine, Division of Cell Biology, Faculty of Health Sciences, Linköping University, Linköping, Sweden.
Zeier Z; Center for Therapeutic Innovation, University of Miami Miller School of Medicine, Miami, Florida, USA.; Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, Florida, USA.
Wahlestedt C; Center for Therapeutic Innovation, University of Miami Miller School of Medicine, Miami, Florida, USA.; Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, Florida, USA.; Pokaż więcej
Źródło:: Addiction biology [Addict Biol] 2021 Jan; Vol. 26 (1), pp. e12816. Date of Electronic Publication: 2019 Aug 01.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:: Alcoholism/*genetics
Jumonji Domain-Containing Histone Demethylases/*genetics
Animals ; Cells, Cultured ; Epigenesis, Genetic ; Ethanol/metabolism ; Histone Demethylases/genetics ; Histones/metabolism ; Humans ; Prefrontal Cortex/metabolism ; Rats ; Signal Transduction ; Up-Regulation

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Skocz do pozycji: 57.

Tytuł:: JMJD6-BRD4 complex stimulates lncRNA HOTAIR transcription by binding to the promoter region of HOTAIR and induces radioresistance in liver cancer stem cells.
Autorzy:: Pei R; Department of Hepatopancreatobiliary Surgery, Xuzhou Cancer Hospital, Gulou District, No. 131, Huancheng Road, Xuzhou, 221005, Jiangsu, People's Republic of China.
Zhao L; Department of Hepatopancreatobiliary Surgery, Xuzhou Cancer Hospital, Gulou District, No. 131, Huancheng Road, Xuzhou, 221005, Jiangsu, People's Republic of China.
Ding Y; Department of Hepatopancreatobiliary Surgery, Xuzhou Cancer Hospital, Gulou District, No. 131, Huancheng Road, Xuzhou, 221005, Jiangsu, People's Republic of China.
Su Z; Department of Hepatopancreatobiliary Surgery, Xuzhou Cancer Hospital, Gulou District, No. 131, Huancheng Road, Xuzhou, 221005, Jiangsu, People's Republic of China.
Li D; Department of Hepatopancreatobiliary Surgery, Xuzhou Cancer Hospital, Gulou District, No. 131, Huancheng Road, Xuzhou, 221005, Jiangsu, People's Republic of China.
Zhu S; Department of Hepatopancreatobiliary Surgery, Xuzhou Cancer Hospital, Gulou District, No. 131, Huancheng Road, Xuzhou, 221005, Jiangsu, People's Republic of China.
Xu L; Department of Hepatopancreatobiliary Surgery, Xuzhou Cancer Hospital, Gulou District, No. 131, Huancheng Road, Xuzhou, 221005, Jiangsu, People's Republic of China.
Zhao W; Department of Hepatopancreatobiliary Surgery, Xuzhou Cancer Hospital, Gulou District, No. 131, Huancheng Road, Xuzhou, 221005, Jiangsu, People's Republic of China. .
Zhou W; Department of Hepatopancreatobiliary Surgery, Xuzhou Cancer Hospital, Gulou District, No. 131, Huancheng Road, Xuzhou, 221005, Jiangsu, People's Republic of China. .; Pokaż więcej
Źródło:: Journal of translational medicine [J Transl Med] 2023 Oct 25; Vol. 21 (1), pp. 752. Date of Electronic Publication: 2023 Oct 25.
Typ publikacji:: Journal Article
MeSH Terms:: Liver Neoplasms*/genetics
Liver Neoplasms*/radiotherapy
Liver Neoplasms*/metabolism
RNA, Long Noncoding*/genetics
RNA, Long Noncoding*/metabolism
Humans ; Cell Cycle Proteins/genetics ; Cell Line, Tumor ; Cell Proliferation/genetics ; Gene Expression Regulation, Neoplastic ; Histone Demethylases/genetics ; Histone Demethylases/metabolism ; Jumonji Domain-Containing Histone Demethylases/genetics ; Neoplastic Stem Cells/metabolism ; Nuclear Proteins/metabolism ; Promoter Regions, Genetic/genetics ; Transcription Factors/metabolism

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Tytuł:: Vitamin C activates young LINE-1 elements in mouse embryonic stem cells via H3K9me3 demethylation.
Autorzy:: Cheng KCL; Blizard Institute, Faculty of Medicine and Dentistry, QMUL, London, E1 2AT, UK.; Computational Biology Program, Ontario Institute for Cancer Research, Toronto, ON, Canada.
Frost JM; Blizard Institute, Faculty of Medicine and Dentistry, QMUL, London, E1 2AT, UK.
Sánchez-Luque FJ; Institute of Parasitology and Biomedicine 'Lopez-Neyra' (IPBLN), Spanish National Research Council (CSIC), PTS Granada, Granada, Spain.
García-Canãdas M; Pfizer-University of Granada-Andalusian Government Centre for Genomics and Oncological Research (GENYO), PTS Granada, Granada, Spain.
Taylor D; Blizard Institute, Faculty of Medicine and Dentistry, QMUL, London, E1 2AT, UK.; MRC London Institute of Medical Sciences, London, W12 0NN, UK.
Yang WR; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Irayanar B; Blizard Institute, Faculty of Medicine and Dentistry, QMUL, London, E1 2AT, UK.
Sampath S; Blizard Institute, Faculty of Medicine and Dentistry, QMUL, London, E1 2AT, UK.
Patani H; Barts Cancer Institute, Faculty of Medicine and Dentistry, QMUL, London, EC1M 6BQ, UK.
Agger K; The Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), University of Copenhagen, Copenhagen, Denmark.
Helin K; The Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), University of Copenhagen, Copenhagen, Denmark.; The Institute of Cancer Research, London, UK.
Ficz G; Barts Cancer Institute, Faculty of Medicine and Dentistry, QMUL, London, EC1M 6BQ, UK.
Burns KH; Department of Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.
Ewing A; Mater Research Institute, University of Queensland, Woolloongabba, QLD, 4102, Australia.
García-Pérez JL; Pfizer-University of Granada-Andalusian Government Centre for Genomics and Oncological Research (GENYO), PTS Granada, Granada, Spain.
Branco MR; Blizard Institute, Faculty of Medicine and Dentistry, QMUL, London, E1 2AT, UK. .; Pokaż więcej
Źródło:: Epigenetics & chromatin [Epigenetics Chromatin] 2023 Oct 16; Vol. 16 (1), pp. 39. Date of Electronic Publication: 2023 Oct 16.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Ascorbic Acid*/pharmacology
Mouse Embryonic Stem Cells*/metabolism
Humans ; Animals ; Mice ; Long Interspersed Nucleotide Elements ; DNA Methylation ; Histone Demethylases/metabolism ; DNA/metabolism ; Demethylation ; Jumonji Domain-Containing Histone Demethylases/genetics ; Jumonji Domain-Containing Histone Demethylases/metabolism

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Skocz do pozycji: 59.

Tytuł:: Oocyte-Specific Knockout of Histone Lysine Demethylase KDM2a Compromises Fertility by Blocking the Development of Follicles and Oocytes.
Autorzy:: Xiong X; Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Exploitation of Ministry of Education, Southwest Minzu University, Chengdu 610041, China.; Key Laboratory for Animal Science of National Ethnic Affairs Commission, Southwest Minzu University, Chengdu 610041, China.
Zhang X; Center for Assisted Reproduction, Sichuan Academy of Medical Science, Sichuan Provincial People's Hospital, Chengdu 610072, China.
Yang M; Key Laboratory for Animal Science of National Ethnic Affairs Commission, Southwest Minzu University, Chengdu 610041, China.
Zhu Y; Key Laboratory for Animal Science of National Ethnic Affairs Commission, Southwest Minzu University, Chengdu 610041, China.
Yu H; Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Exploitation of Ministry of Education, Southwest Minzu University, Chengdu 610041, China.
Fei X; Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Exploitation of Ministry of Education, Southwest Minzu University, Chengdu 610041, China.
Mastuda F; Laboratory of Theriogenology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan.
Lan D; Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Exploitation of Ministry of Education, Southwest Minzu University, Chengdu 610041, China.
Xiong Y; Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Exploitation of Ministry of Education, Southwest Minzu University, Chengdu 610041, China.
Fu W; Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Exploitation of Ministry of Education, Southwest Minzu University, Chengdu 610041, China.
Yin S; Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Exploitation of Ministry of Education, Southwest Minzu University, Chengdu 610041, China.
Li J; Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Exploitation of Ministry of Education, Southwest Minzu University, Chengdu 610041, China.; Key Laboratory for Animal Science of National Ethnic Affairs Commission, Southwest Minzu University, Chengdu 610041, China.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2022 Oct 09; Vol. 23 (19). Date of Electronic Publication: 2022 Oct 09.
Typ publikacji:: Journal Article
MeSH Terms:: Histones*/metabolism
Jumonji Domain-Containing Histone Demethylases*/genetics
Animals ; Estradiol/metabolism ; Female ; Fertility/genetics ; Lysine/metabolism ; Male ; Mice ; Mice, Knockout ; Oocytes/metabolism ; RNA, Messenger/metabolism

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Skocz do pozycji: 60.

Tytuł:: A Screening of Epigenetic Therapeutic Targets for Non-Small Cell Lung Cancer Reveals PADI4 and KDM6B as Promising Candidates.
Autorzy:: Lesbon JCC; Laboratory of Comparative and Translational Oncology, Department of Veterinary Medicine, Faculty of Animal Science and Food Engineering, University of São Paulo, Duque de Caxias, 225-Jardim Elite, Pirassununga 13635-900, SP, Brazil.
Garnica TK; Laboratory of Comparative and Translational Oncology, Department of Veterinary Medicine, Faculty of Animal Science and Food Engineering, University of São Paulo, Duque de Caxias, 225-Jardim Elite, Pirassununga 13635-900, SP, Brazil.
Xavier PLP; Laboratory of Comparative and Translational Oncology, Department of Veterinary Medicine, Faculty of Animal Science and Food Engineering, University of São Paulo, Duque de Caxias, 225-Jardim Elite, Pirassununga 13635-900, SP, Brazil.
Rochetti AL; Laboratory of Comparative and Translational Oncology, Department of Veterinary Medicine, Faculty of Animal Science and Food Engineering, University of São Paulo, Duque de Caxias, 225-Jardim Elite, Pirassununga 13635-900, SP, Brazil.
Reis RM; Molecular Oncology Research Center, Hospital de Amor, Antenor Duarte Viléla, 1331-Dr. Paulo Prata, Barretos 14784-400, SP, Brazil.; Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, 4710-057 Braga, Portugal.; ICVS/3B's-PT Government Associate Laboratory, 4710-057 Braga, Portugal.; ICVS/3B's-PT Government Associate Laboratory, 4805-017 Guimarães, Portugal.
Müller S; Structural Genomics Consortium, Buchmann Institute for Molecular Life Sciences, Johann Wolfgang Goethe University, Max-von-Laue-Str 15-60438, 60438 Frankfurt am Main, Germany.
Fukumasu H; Laboratory of Comparative and Translational Oncology, Department of Veterinary Medicine, Faculty of Animal Science and Food Engineering, University of São Paulo, Duque de Caxias, 225-Jardim Elite, Pirassununga 13635-900, SP, Brazil.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2022 Oct 07; Vol. 23 (19). Date of Electronic Publication: 2022 Oct 07.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Adenocarcinoma of Lung*/drug therapy
Adenocarcinoma of Lung*/genetics
Carcinoma, Non-Small-Cell Lung*/drug therapy
Carcinoma, Non-Small-Cell Lung*/genetics
Jumonji Domain-Containing Histone Demethylases*/genetics
Lung Neoplasms*/drug therapy
Lung Neoplasms*/genetics
Protein-Arginine Deiminase Type 4*/genetics
Cell Line, Tumor ; Early Detection of Cancer ; Epigenesis, Genetic ; Gene Expression Regulation, Neoplastic ; Humans

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