Autor: "Hla, Timothy" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Sphingosine 1-phosphate: Lipid signaling in pathology and therapy.
Autorzy:: Cartier A; Vascular Biology Program, Boston Children's Hospital and Department of Surgery, Harvard Medical School, Boston, MA 02115, USA.
Hla T; Vascular Biology Program, Boston Children's Hospital and Department of Surgery, Harvard Medical School, Boston, MA 02115, USA. timothy.hla@childrens.harvard.edu.; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2019 Oct 18; Vol. 366 (6463).
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms:: Lysophospholipids/*metabolism
Sphingosine/*analogs & derivatives
Sphingosine-1-Phosphate Receptors/*metabolism
Animals ; Apolipoproteins M/metabolism ; Autoimmune Diseases/drug therapy ; Autoimmune Diseases/physiopathology ; Cardiovascular Diseases/drug therapy ; Cardiovascular Diseases/physiopathology ; Cardiovascular Physiological Phenomena ; Cardiovascular System/embryology ; Cardiovascular System/growth & development ; Cardiovascular System/metabolism ; Central Nervous System/growth & development ; Central Nervous System/physiology ; Drug Development ; Fibrosis/drug therapy ; Fibrosis/physiopathology ; Homeostasis ; Humans ; Immune System Phenomena ; Mice ; Molecular Chaperones ; Neurodegenerative Diseases/drug therapy ; Neurodegenerative Diseases/physiopathology ; Signal Transduction ; Sphingosine/metabolism ; Sphingosine-1-Phosphate Receptors/antagonists & inhibitors

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Skocz do pozycji: 2.

Tytuł:: HDL-bound sphingosine-1-phosphate restrains lymphopoiesis and neuroinflammation.
Autorzy:: Blaho VA; 1] Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, New York 10065, USA [2] Brain and Mind Research Institute, Weill Medical College of Cornell University, New York, New York 10065, USA.
Galvani S; Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, New York 10065, USA.
Engelbrecht E; Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, New York 10065, USA.
Liu C; Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, New York 10065, USA.
Swendeman SL; Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, New York 10065, USA.
Kono M; Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland 20892, USA.
Proia RL; Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland 20892, USA.
Steinman L; Department of Neurology and Neurological Sciences, Stanford University, Stanford, California 94305, USA.
Han MH; Department of Neurology and Neurological Sciences, Stanford University, Stanford, California 94305, USA.
Hla T; 1] Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, New York 10065, USA [2] Brain and Mind Research Institute, Weill Medical College of Cornell University, New York, New York 10065, USA.; Pokaż więcej
Źródło:: Nature [Nature] 2015 Jul 16; Vol. 523 (7560), pp. 342-6. Date of Electronic Publication: 2015 Jun 08.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Lymphopoiesis*
Apolipoproteins/*metabolism
Central Nervous System/*pathology
Lipoproteins, HDL/*metabolism
Lymphocytes/*cytology
Lymphocytes/*metabolism
Lysophospholipids/*metabolism
Sphingosine/*analogs & derivatives
Animals ; Apolipoproteins/deficiency ; Apolipoproteins/genetics ; Apolipoproteins M ; Blood-Brain Barrier/pathology ; Cell Movement ; Cell Proliferation/genetics ; Central Nervous System/immunology ; Central Nervous System/metabolism ; Encephalomyelitis, Autoimmune, Experimental/genetics ; Encephalomyelitis, Autoimmune, Experimental/immunology ; Encephalomyelitis, Autoimmune, Experimental/metabolism ; Encephalomyelitis, Autoimmune, Experimental/pathology ; Female ; Fingolimod Hydrochloride/pharmacology ; Hematopoietic Stem Cells/cytology ; Hematopoietic Stem Cells/metabolism ; Inflammation/immunology ; Inflammation/metabolism ; Inflammation/pathology ; Lymphocytes/immunology ; Lymphoid Progenitor Cells/cytology ; Lymphoid Progenitor Cells/metabolism ; Lysophospholipids/agonists ; Lysophospholipids/blood ; Lysophospholipids/genetics ; Male ; Mice ; Mice, Inbred C57BL ; Protein Binding ; Receptors, Lysosphingolipid/metabolism ; Signal Transduction ; Sphingosine/agonists ; Sphingosine/blood ; Sphingosine/genetics ; Sphingosine/metabolism