Baricitinib treatment resolves lower airway inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques.
Autorzy :
Hoang TN; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Pino M; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Boddapati AK; Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Viox EG; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Starke CE; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR, USA. Upadhyay AA; Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Gumber S; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, Georgia, USA.; Division of Pathology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Busman-Sahay K; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR, USA. Strongin Z; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Harper JL; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Tharp GK; Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Pellegrini KL; Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Kirejczyk S; Division of Pathology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Zandi K; Center for AIDS Research, Department of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia, USA. Tao S; Center for AIDS Research, Department of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia, USA. Horton TR; Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Beagle EN; Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Mahar EA; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Lee MY; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Cohen J; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Jean SM; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Wood JS; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Connor-Stroud F; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Stammen RL; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Delmas OM; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Wang S; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Cooney KA; Department of Medicine, School of Medicine, Emory University, Atlanta, Georgia, USA. Sayegh MN; Department of Medicine, School of Medicine, Emory University, Atlanta, Georgia, USA. Wang L; Department of Medicine, School of Medicine, Emory University, Atlanta, Georgia, USA. Weiskopf D; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, USA. Filev PD; Department of Radiology and Imaging Sciences, School of Medicine, Emory University, Atlanta, Georgia, USA. Waggoner J; Department of Medicine, School of Medicine, Emory University, Atlanta, Georgia, USA. Piantadosi A; Department of Medicine, School of Medicine, Emory University, Atlanta, Georgia, USA.; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, Georgia, USA. Kasturi SP; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Al-Shakhshir H; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA. Ribeiro SP; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA. Sekaly RP; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA. Levit RD; Department of Medicine, School of Medicine, Emory University, Atlanta, Georgia, USA. Estes JD; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR, USA.; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA. Vanderford TH; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Schinazi RF; Center for AIDS Research, Department of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia, USA. Bosinger SE; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.; Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, Georgia, USA. Paiardini M; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, Georgia, USA.
Bone Marrow-Derived CD4 T Cells Are Depleted in Simian Immunodeficiency Virus-Infected Macaques and Contribute to the Size of the Replication-Competent Reservoir.
Autorzy :
Hoang TN; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, Georgia, USA. Harper JL; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, Georgia, USA. Pino M; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, Georgia, USA. Wang H; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, Georgia, USA. Micci L; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, Georgia, USA. King CT; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, Georgia, USA. McGary CS; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, Georgia, USA. McBrien JB; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, Georgia, USA. Cervasi B; Flow Cytometry Core, Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. Silvestri G; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, Georgia, USA.; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA. Paiardini M; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, Georgia, USA .; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA.
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Źródło :
Journal of virology [J Virol] 2018 Dec 10; Vol. 93 (1). Date of Electronic Publication: 2018 Dec 10 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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