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Wyświetlanie 1-17 z 17
Tytuł:
PIK3CA mutations and their impact on survival outcomes of patients with endometrial cancer: A systematic review and meta-analysis.
Autorzy:
Bredin HK; Department of Clinical Science, Centre for Cancer Biomarkers, University of Bergen, Bergen, Norway.; Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway.
Krakstad C; Department of Clinical Science, Centre for Cancer Biomarkers, University of Bergen, Bergen, Norway.; Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway.
Hoivik EA; Department of Clinical Science, Centre for Cancer Biomarkers, University of Bergen, Bergen, Norway.; Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway.
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Źródło:
PloS one [PLoS One] 2023 Mar 21; Vol. 18 (3), pp. e0283203. Date of Electronic Publication: 2023 Mar 21 (Print Publication: 2023).
Typ publikacji:
Meta-Analysis; Systematic Review; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Phosphatidylinositol 3-Kinases*/genetics
Phosphatidylinositol 3-Kinases*/metabolism
Endometrial Neoplasms*/pathology
Humans ; Female ; Signal Transduction ; Mutation ; Class I Phosphatidylinositol 3-Kinases/genetics ; Class I Phosphatidylinositol 3-Kinases/metabolism
Czasopismo naukowe
Tytuł:
A radiogenomics application for prognostic profiling of endometrial cancer.
Autorzy:
Hoivik EA; Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway. Erling.Hoivik@uib.no.; Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway. Erling.Hoivik@uib.no.; Mohn Medical Imaging and Visualization Centre (MMIV), Department of Radiology, Haukeland University Hospital, Bergen, Norway. Erling.Hoivik@uib.no.; Section of Radiology, Department of Clinical Medicine, University of Bergen, Bergen, Norway. Erling.Hoivik@uib.no.
Hodneland E; Mohn Medical Imaging and Visualization Centre (MMIV), Department of Radiology, Haukeland University Hospital, Bergen, Norway.; Section of Radiology, Department of Clinical Medicine, University of Bergen, Bergen, Norway.
Dybvik JA; Mohn Medical Imaging and Visualization Centre (MMIV), Department of Radiology, Haukeland University Hospital, Bergen, Norway.; Section of Radiology, Department of Clinical Medicine, University of Bergen, Bergen, Norway.
Wagner-Larsen KS; Mohn Medical Imaging and Visualization Centre (MMIV), Department of Radiology, Haukeland University Hospital, Bergen, Norway.; Section of Radiology, Department of Clinical Medicine, University of Bergen, Bergen, Norway.
Fasmer KE; Mohn Medical Imaging and Visualization Centre (MMIV), Department of Radiology, Haukeland University Hospital, Bergen, Norway.; Section of Radiology, Department of Clinical Medicine, University of Bergen, Bergen, Norway.
Berg HF; Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway.; Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway.
Halle MK; Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway.; Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway.
Haldorsen IS; Mohn Medical Imaging and Visualization Centre (MMIV), Department of Radiology, Haukeland University Hospital, Bergen, Norway. .; Section of Radiology, Department of Clinical Medicine, University of Bergen, Bergen, Norway. .
Krakstad C; Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway. .; Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway. .
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Źródło:
Communications biology [Commun Biol] 2021 Dec 06; Vol. 4 (1), pp. 1363. Date of Electronic Publication: 2021 Dec 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Algorithms*
Machine Learning*
Endometrial Neoplasms/*diagnosis
Imaging Genomics/*statistics & numerical data
Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Middle Aged ; Prognosis
Czasopismo naukowe
Tytuł:
A Gene Signature Identifying CIN3 Regression and Cervical Cancer Survival.
Autorzy:
Halle MK; Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, 5053 Bergen, Norway.; Department of Obstetrics and Gynaecology, Haukeland University Hospital, 5053 Bergen, Norway.
Munk AC; Department of Obstetrics and Gynaecology, Sørlandet Hospital Kristiansand, 4604 Kristiansand, Norway.
Engesæter B; Section for Cervical Cancer Screening, Cancer Registry of Norway, 0304 Oslo, Norway.
Akbari S; Department of Pathology, Stavanger University Hospital, 4068 Stavanger, Norway.
Frafjord A; Department of Pathology, Stavanger University Hospital, 4068 Stavanger, Norway.
Hoivik EA; Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, 5053 Bergen, Norway.; Department of Obstetrics and Gynaecology, Haukeland University Hospital, 5053 Bergen, Norway.
Forsse D; Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, 5053 Bergen, Norway.; Department of Obstetrics and Gynaecology, Haukeland University Hospital, 5053 Bergen, Norway.
Fasmer KE; Section for Radiology, Department of Clinical Medicine, University of Bergen, 5021 Bergen, Norway.; Mohn Medical Imaging and Visualization Centre, Department of Radiology, Haukeland University Hospital, 5021 Bergen, Norway.
Woie K; Department of Obstetrics and Gynaecology, Haukeland University Hospital, 5053 Bergen, Norway.
Haldorsen IS; Section for Radiology, Department of Clinical Medicine, University of Bergen, 5021 Bergen, Norway.; Mohn Medical Imaging and Visualization Centre, Department of Radiology, Haukeland University Hospital, 5021 Bergen, Norway.
Bertelsen BI; Department of Pathology, Haukeland University Hospital, 5021 Bergen, Norway.
Janssen EAM; Department of Pathology, Stavanger University Hospital, 4068 Stavanger, Norway.; Department of Chemistry, Bioscience and Environmental Technology, University of Stavanger, 4036 Stavanger, Norway.
Gudslaugsson E; Department of Pathology, Stavanger University Hospital, 4068 Stavanger, Norway.
Krakstad C; Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, 5053 Bergen, Norway.; Department of Obstetrics and Gynaecology, Haukeland University Hospital, 5053 Bergen, Norway.
Øvestad IT; Department of Pathology, Stavanger University Hospital, 4068 Stavanger, Norway.
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Źródło:
Cancers [Cancers (Basel)] 2021 Nov 16; Vol. 13 (22). Date of Electronic Publication: 2021 Nov 16.
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
An MRI-Based Radiomic Prognostic Index Predicts Poor Outcome and Specific Genetic Alterations in Endometrial Cancer.
Autorzy:
Jacob H; Section of Radiology, Department of Clinical Medicine, University of Bergen, 5020 Bergen, Norway.; Mohn Medical Imaging and Visualization Centre (MMIV), Department of Radiology, Haukeland University Hospital, 5021 Bergen, Norway.; Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, 5021 Bergen, Norway.
Dybvik JA; Section of Radiology, Department of Clinical Medicine, University of Bergen, 5020 Bergen, Norway.; Mohn Medical Imaging and Visualization Centre (MMIV), Department of Radiology, Haukeland University Hospital, 5021 Bergen, Norway.
Ytre-Hauge S; Section of Radiology, Department of Clinical Medicine, University of Bergen, 5020 Bergen, Norway.; Mohn Medical Imaging and Visualization Centre (MMIV), Department of Radiology, Haukeland University Hospital, 5021 Bergen, Norway.
Fasmer KE; Section of Radiology, Department of Clinical Medicine, University of Bergen, 5020 Bergen, Norway.; Mohn Medical Imaging and Visualization Centre (MMIV), Department of Radiology, Haukeland University Hospital, 5021 Bergen, Norway.
Hoivik EA; Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, 5021 Bergen, Norway.; Department of Obstetrics and Gynaecology, Haukeland University Hospital, 5021 Bergen, Norway.
Trovik J; Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, 5021 Bergen, Norway.; Department of Obstetrics and Gynaecology, Haukeland University Hospital, 5021 Bergen, Norway.
Krakstad C; Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, 5021 Bergen, Norway.; Department of Obstetrics and Gynaecology, Haukeland University Hospital, 5021 Bergen, Norway.
Haldorsen IS; Section of Radiology, Department of Clinical Medicine, University of Bergen, 5020 Bergen, Norway.; Mohn Medical Imaging and Visualization Centre (MMIV), Department of Radiology, Haukeland University Hospital, 5021 Bergen, Norway.
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Źródło:
Journal of clinical medicine [J Clin Med] 2021 Feb 02; Vol. 10 (3). Date of Electronic Publication: 2021 Feb 02.
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Class I Phosphoinositide 3-Kinase PIK3CA /p110α and PIK3CB /p110β Isoforms in Endometrial Cancer.
Autorzy:
Mazloumi Gavgani F; Department of Biological Science, University of Bergen, 5008 Bergen, Norway. .
Smith Arnesen V; Department of Biological Science, University of Bergen, 5008 Bergen, Norway. .
Jacobsen RG; Department of Biological Science, University of Bergen, 5008 Bergen, Norway. .
Krakstad C; Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, 5021 Bergen, Norway. .; Department of Gynecology and Obstetrics, Haukeland University Hospital, 5053 Bergen, Norway. .
Hoivik EA; Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, 5021 Bergen, Norway. Erling.Hoivik@uib.no.; Department of Gynecology and Obstetrics, Haukeland University Hospital, 5053 Bergen, Norway. Erling.Hoivik@uib.no.
Lewis AE; Department of Biological Science, University of Bergen, 5008 Bergen, Norway. .
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2018 Dec 07; Vol. 19 (12). Date of Electronic Publication: 2018 Dec 07.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Class I Phosphatidylinositol 3-Kinases/*metabolism
Endometrial Neoplasms/*enzymology
Endometrial Neoplasms/*metabolism
PTEN Phosphohydrolase/*metabolism
Phosphatidylinositol 3-Kinase/*metabolism
Animals ; Class I Phosphatidylinositol 3-Kinases/genetics ; Endometrial Neoplasms/genetics ; Female ; Humans ; PTEN Phosphohydrolase/genetics ; Phosphatidylinositol 3-Kinase/genetics
Czasopismo naukowe
Tytuł:
Identification of highly connected and differentially expressed gene subnetworks in metastasizing endometrial cancer.
Autorzy:
Kusonmano K; Computational Biology Unit, Department of Informatics, University of Bergen, Bergen, Norway.; Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway.; Bioinformatics and Systems Biology Program, School of Bioresources and Technology, King Mongkut's University of Technology Thonburi, Bangkok, Thailand.
Halle MK; Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway.; Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway.
Wik E; Centre for Cancer Biomarkers, Department of Clinical Medicine, University of Bergen, Bergen, Norway.; Department of Pathology, The Gade Institute, Haukeland University Hospital, Bergen, Norway.
Hoivik EA; Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway.; Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway.
Krakstad C; Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway.; Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway.
Mauland KK; Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway.; Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway.
Tangen IL; Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway.; Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway.
Berg A; Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway.; Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway.
Werner HMJ; Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway.; Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway.
Trovik J; Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway.; Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway.
Øyan AM; Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway.; Department of Microbiology, Haukeland University Hospital, Bergen, Norway.
Kalland KH; Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway.; Department of Microbiology, Haukeland University Hospital, Bergen, Norway.
Jonassen I; Computational Biology Unit, Department of Informatics, University of Bergen, Bergen, Norway.; Centre for Cancer Biomarkers, Department of Informatics, University of Bergen, Bergen, Norway.
Salvesen HB; Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway.; Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway.
Petersen K; Computational Biology Unit, Department of Informatics, University of Bergen, Bergen, Norway.
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Źródło:
PloS one [PLoS One] 2018 Nov 01; Vol. 13 (11), pp. e0206665. Date of Electronic Publication: 2018 Nov 01 (Print Publication: 2018).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Carcinoma/*genetics
Carcinoma/*metabolism
Endometrial Neoplasms/*genetics
Endometrial Neoplasms/*metabolism
Neoplasm Metastasis/*genetics
Neoplasm Metastasis/*physiopathology
Cell Proliferation ; Computational Biology ; Epithelial-Mesenchymal Transition/physiology ; Female ; Gene Expression Regulation, Neoplastic ; Gene Regulatory Networks ; Humans ; Hypoxia/genetics ; Hypoxia/metabolism ; Models, Statistical ; RNA/metabolism ; Software
Czasopismo naukowe
Tytuł:
Deletion of exchange proteins directly activated by cAMP (Epac) causes defects in hippocampal signaling in female mice.
Autorzy:
Aesoy R; Department of Clinical Science, University of Bergen, Bergen, Norway.
Muwonge H; Department of Biomedicine, University of Bergen, Bergen, Norway.
Asrud KS; Department of Biomedicine, University of Bergen, Bergen, Norway.
Sabir M; Department of Clinical Science, University of Bergen, Bergen, Norway.
Witsoe SL; Department of Clinical Medicine, University of Bergen, Bergen, Norway.
Bjornstad R; Department of Clinical Science, University of Bergen, Bergen, Norway.
Kopperud RK; Department of Clinical Science, University of Bergen, Bergen, Norway.
Hoivik EA; Department of Clinical Science, University of Bergen, Bergen, Norway.
Doskeland SO; Department of Biomedicine, University of Bergen, Bergen, Norway.
Bakke M; Department of Biomedicine, University of Bergen, Bergen, Norway.
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Źródło:
PloS one [PLoS One] 2018 Jul 26; Vol. 13 (7), pp. e0200935. Date of Electronic Publication: 2018 Jul 26 (Print Publication: 2018).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Deletion*
Guanine Nucleotide Exchange Factors/*deficiency
Guanine Nucleotide Exchange Factors/*genetics
Hippocampus/*cytology
Signal Transduction/*genetics
Animals ; Corticosterone/blood ; Female ; Hippocampus/metabolism ; Hippocampus/pathology ; Male ; Mice ; Mice, Inbred C57BL ; MicroRNAs/genetics ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Stress, Psychological/genetics ; Stress, Psychological/pathology
Czasopismo naukowe
Tytuł:
Corrigendum: Recurrent hormone-binding domain truncated ESR1 amplifications in primary endometrial cancers suggest their implication in hormone independent growth.
Autorzy:
Holst F
Hoivik EA
Gibson WJ
Taylor-Weiner A
Schumacher SE
Asmann YW
Grossmann P
Trovik J
Necela BM
Thompson EA
Meyerson M
Beroukhim R
Salvesen HB
Cherniack AD
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Źródło:
Scientific reports [Sci Rep] 2017 Jun 30; Vol. 7, pp. 46873. Date of Electronic Publication: 2017 Jun 30.
Typ publikacji:
Journal Article; Published Erratum
Czasopismo naukowe
Tytuł:
Increased microvascular permeability in mice lacking Epac1 (Rapgef3).
Autorzy:
Kopperud RK; Department of Biomedicine, University of Bergen, Bergen, Norway.; Centre for Cancer Biomarkers (CCBIO), University of Bergen, Bergen, Norway.
Rygh CB; Department of Biomedicine, University of Bergen, Bergen, Norway.
Karlsen TV; Department of Biomedicine, University of Bergen, Bergen, Norway.
Krakstad C; Department of Biomedicine, University of Bergen, Bergen, Norway.
Kleppe R; Department of Biomedicine, University of Bergen, Bergen, Norway.
Hoivik EA; Department of Biomedicine, University of Bergen, Bergen, Norway.
Bakke M; Department of Biomedicine, University of Bergen, Bergen, Norway.
Tenstad O; Department of Biomedicine, University of Bergen, Bergen, Norway.
Selheim F; Department of Biomedicine, University of Bergen, Bergen, Norway.
Lidén Å; Department of Biomedicine, University of Bergen, Bergen, Norway.
Madsen L; Department of Biomedicine, University of Bergen, Bergen, Norway.; Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Pavlin T; Department of Biomedicine, University of Bergen, Bergen, Norway.
Taxt T; Department of Biomedicine, University of Bergen, Bergen, Norway.
Kristiansen K; Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Curry FE; Department of Physiology and Membrane Biology, School of Medicine, University of California, Davis, CA, USA.
Reed RK; Department of Biomedicine, University of Bergen, Bergen, Norway.; Centre for Cancer Biomarkers (CCBIO), University of Bergen, Bergen, Norway.
Døskeland SO; Department of Biomedicine, University of Bergen, Bergen, Norway.
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Źródło:
Acta physiologica (Oxford, England) [Acta Physiol (Oxf)] 2017 Feb; Vol. 219 (2), pp. 441-452. Date of Electronic Publication: 2016 May 17.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Capillary Permeability/*physiology
Guanine Nucleotide Exchange Factors/*metabolism
Animals ; Blotting, Western ; Disease Models, Animal ; Female ; Immunohistochemistry ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Microscopy, Electron, Transmission
Czasopismo naukowe
Tytuł:
Long-term consumption of an obesogenic high fat diet prior to ischemia-reperfusion mediates cardioprotection via Epac1-dependent signaling.
Autorzy:
Edland F; Department of Biomedicine, Faculty of Medicine and Dentistry, University of Bergen, Bergen, Norway.
Wergeland A; Department of Biomedicine, Faculty of Medicine and Dentistry, University of Bergen, Bergen, Norway.
Kopperud R; Department of Biomedicine, Faculty of Medicine and Dentistry, University of Bergen, Bergen, Norway.
Åsrud KS; Department of Biomedicine, Faculty of Medicine and Dentistry, University of Bergen, Bergen, Norway.
Hoivik EA; Department of Biomedicine, Faculty of Medicine and Dentistry, University of Bergen, Bergen, Norway.
Witsø SL; Department of Biomedicine, Faculty of Medicine and Dentistry, University of Bergen, Bergen, Norway.
Æsøy R; Department of Biomedicine, Faculty of Medicine and Dentistry, University of Bergen, Bergen, Norway.
Madsen L; Department of Biology, University of Copenhagen, Copenhagen, Denmark ; National Institute of Nutrition and Seafood Research, Bergen, Norway.
Kristiansen K; Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Bakke M; Department of Biomedicine, Faculty of Medicine and Dentistry, University of Bergen, Bergen, Norway.
Døskeland SO; Department of Biomedicine, Faculty of Medicine and Dentistry, University of Bergen, Bergen, Norway.
Jonassen AK; Department of Biomedicine, Faculty of Medicine and Dentistry, University of Bergen, Bergen, Norway ; Faculty of Health Science and Medicine, Norwegian University of Science and Technology, NTNU, Trondheim, Norway.
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Źródło:
Nutrition & metabolism [Nutr Metab (Lond)] 2016 Nov 28; Vol. 13, pp. 87. Date of Electronic Publication: 2016 Nov 28 (Print Publication: 2016).
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Corrigendum: Recurrent hormone-binding domain truncated ESR1 amplifications in primary endometrial cancers suggest their implication in hormone independent growth.
Autorzy:
Holst F
Hoivik EA
Gibson WJ
Taylor-Weiner A
Schumacher SE
Asmann YW
Grossmann P
Trovik J
Necela BM
Thompson EA
Meyerson M
Beroukhim R
Salvesen HB
Cherniack AD
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Źródło:
Scientific reports [Sci Rep] 2016 Jun 24; Vol. 6, pp. 27960. Date of Electronic Publication: 2016 Jun 24.
Typ publikacji:
Journal Article; Published Erratum
Czasopismo naukowe
Tytuł:
Recurrent hormone-binding domain truncated ESR1 amplifications in primary endometrial cancers suggest their implication in hormone independent growth.
Autorzy:
Holst F; Centre for Cancer Biomarkers, Department of Clinical Science, The University of Bergen, Norway.; KG Jebsen Center for Precision Medicine in Gynecologic Cancer, Department of Gynecology and Obstetrics, Haukeland University Hospital Bergen, Norway.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.
Hoivik EA; Centre for Cancer Biomarkers, Department of Clinical Science, The University of Bergen, Norway.; KG Jebsen Center for Precision Medicine in Gynecologic Cancer, Department of Gynecology and Obstetrics, Haukeland University Hospital Bergen, Norway.
Gibson WJ; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Taylor-Weiner A; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Schumacher SE; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.
Asmann YW; Department of Health Sciences Research, Mayo Clinic Cancer Center, Jacksonville, Florida 32224, USA.
Grossmann P; Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Department of Biostatistics &Computational Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Trovik J; Centre for Cancer Biomarkers, Department of Clinical Science, The University of Bergen, Norway.; KG Jebsen Center for Precision Medicine in Gynecologic Cancer, Department of Gynecology and Obstetrics, Haukeland University Hospital Bergen, Norway.
Necela BM; Department of Cancer Biology, Mayo Clinic Cancer Center, Jacksonville, Florida.
Thompson EA; Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Meyerson M; Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
Beroukhim R; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Salvesen HB; Centre for Cancer Biomarkers, Department of Clinical Science, The University of Bergen, Norway.; KG Jebsen Center for Precision Medicine in Gynecologic Cancer, Department of Gynecology and Obstetrics, Haukeland University Hospital Bergen, Norway.
Cherniack AD; Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
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Źródło:
Scientific reports [Sci Rep] 2016 May 10; Vol. 6, pp. 25521. Date of Electronic Publication: 2016 May 10.
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Regulation of CDKN2B expression by interaction of Arnt with Miz-1--a basis for functional integration between the HIF and Myc gene regulatory pathways.
Autorzy:
Aesoy R; Department of Biomedicine, University of Bergen, Jonas Lies vei 91, N-5009 Bergen, Norway. .
Gradin K
Aasrud KS
Hoivik EA
Ruas JL
Poellinger L
Bakke M
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Źródło:
Molecular cancer [Mol Cancer] 2014 Mar 11; Vol. 13, pp. 54. Date of Electronic Publication: 2014 Mar 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Aryl Hydrocarbon Receptor Nuclear Translocator/*metabolism
Carcinogenesis/*genetics
Cyclin-Dependent Kinase Inhibitor p15/*biosynthesis
Genes, myc/*genetics
Hypoxia-Inducible Factor 1/*genetics
Kruppel-Like Transcription Factors/*metabolism
Cell Line, Tumor ; Chromatin Immunoprecipitation ; Cyclin-Dependent Kinase Inhibitor p15/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; Immunoblotting ; Immunoprecipitation ; RNA Interference ; Reverse Transcriptase Polymerase Chain Reaction ; Signal Transduction/physiology ; Transfection ; Two-Hybrid System Techniques
Czasopismo naukowe
Tytuł:
Landscape of genomic alterations in cervical carcinomas.
Autorzy:
Ojesina AI; 1] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA [2] The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA [3].
Lichtenstein L; 1] The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA [2].
Freeman SS; The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.
Pedamallu CS; 1] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA [2] The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.
Imaz-Rosshandler I; Instituto Nacional de Medicina Genomica, Mexico City 14610, Mexico.
Pugh TJ; 1] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA [2] The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.
Cherniack AD; The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.
Ambrogio L; The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.
Cibulskis K; The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.
Bertelsen B; Department of Pathology, Haukeland University Hospital, N5021 Bergen, Norway.
Romero-Cordoba S; Instituto Nacional de Medicina Genomica, Mexico City 14610, Mexico.
Treviño V; Tecnológico de Monterrey, Monterrey 64849, Mexico.
Vazquez-Santillan K; Instituto Nacional de Medicina Genomica, Mexico City 14610, Mexico.
Guadarrama AS; Instituto Nacional de Medicina Genomica, Mexico City 14610, Mexico.
Wright AA; 1] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA [2] Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
Rosenberg MW; The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.
Duke F; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.
Kaplan B; 1] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA [2] The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.
Wang R; 1] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA [2] Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Nickerson E; The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.
Walline HM; Cancer Biology Program, Program in the Biomedical Sciences, Rackham Graduate School, University of Michigan, Ann Arbor, Michigan 48109, USA.
Lawrence MS; The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.
Stewart C; The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.
Carter SL; The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.
McKenna A; The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.
Rodriguez-Sanchez IP; Facultad de Medicina y Hospital Universitario 'Dr. José Eluterio González' de la Universidad Autónoma de Nuevo León, Monterrey, Nuevo León 64460, México.
Espinosa-Castilla M; Instituto Nacional de Medicina Genomica, Mexico City 14610, Mexico.
Woie K; Department of Obstetrics and Gynecology, Haukeland University Hospital, N5021 Bergen, Norway.
Bjorge L; 1] Department of Obstetrics and Gynecology, Haukeland University Hospital, N5021 Bergen, Norway [2] Department of Clinical Science, Centre for Cancer Biomarkers, University of Bergen, N5020 Bergen, Norway.
Wik E; 1] Department of Obstetrics and Gynecology, Haukeland University Hospital, N5021 Bergen, Norway [2] Department of Clinical Science, Centre for Cancer Biomarkers, University of Bergen, N5020 Bergen, Norway.
Halle MK; 1] Department of Obstetrics and Gynecology, Haukeland University Hospital, N5021 Bergen, Norway [2] Department of Clinical Science, Centre for Cancer Biomarkers, University of Bergen, N5020 Bergen, Norway.
Hoivik EA; 1] Department of Obstetrics and Gynecology, Haukeland University Hospital, N5021 Bergen, Norway [2] Department of Clinical Science, Centre for Cancer Biomarkers, University of Bergen, N5020 Bergen, Norway.
Krakstad C; 1] Department of Obstetrics and Gynecology, Haukeland University Hospital, N5021 Bergen, Norway [2] Department of Clinical Science, Centre for Cancer Biomarkers, University of Bergen, N5020 Bergen, Norway.
Gabiño NB; Instituto Nacional de Medicina Genomica, Mexico City 14610, Mexico.
Gómez-Macías GS; Facultad de Medicina y Hospital Universitario 'Dr. José Eluterio González' de la Universidad Autónoma de Nuevo León, Monterrey, Nuevo León 64460, México.
Valdez-Chapa LD; Facultad de Medicina y Hospital Universitario 'Dr. José Eluterio González' de la Universidad Autónoma de Nuevo León, Monterrey, Nuevo León 64460, México.
Garza-Rodríguez ML; Facultad de Medicina y Hospital Universitario 'Dr. José Eluterio González' de la Universidad Autónoma de Nuevo León, Monterrey, Nuevo León 64460, México.
Maytorena G; Instituto Mexicano del Seguro Social, Mexico City 06720, Mexico.
Vazquez J; Instituto Mexicano del Seguro Social, Mexico City 06720, Mexico.
Rodea C; Instituto Mexicano del Seguro Social, Mexico City 06720, Mexico.
Cravioto A; Instituto Mexicano del Seguro Social, Mexico City 06720, Mexico.
Cortes ML; The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.
Greulich H; 1] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA [2] The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA [3] Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
Crum CP; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
Neuberg DS; Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.
Hidalgo-Miranda A; Instituto Nacional de Medicina Genomica, Mexico City 14610, Mexico.
Escareno CR; 1] Instituto Nacional de Medicina Genomica, Mexico City 14610, Mexico [2] Claremont Graduate University, Claremont, California 91711, USA.
Akslen LA; 1] Department of Pathology, Haukeland University Hospital, N5021 Bergen, Norway [2] Centre for Cancer Biomarkers, Department of Clinical Medicine, University of Bergen, N5020 Bergen, Norway.
Carey TE; Head and Neck Oncology Program and Department of Otolaryngology, University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 38109, USA.
Vintermyr OK; 1] Department of Pathology, Haukeland University Hospital, N5021 Bergen, Norway [2] Centre for Cancer Biomarkers, Department of Clinical Medicine, University of Bergen, N5020 Bergen, Norway.
Gabriel SB; The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.
Barrera-Saldaña HA; Facultad de Medicina y Hospital Universitario 'Dr. José Eluterio González' de la Universidad Autónoma de Nuevo León, Monterrey, Nuevo León 64460, México.
Melendez-Zajgla J; Instituto Nacional de Medicina Genomica, Mexico City 14610, Mexico.
Getz G; 1] The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA [2] Massachusetts General Hospital Cancer Center and Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA.
Salvesen HB; 1] Department of Obstetrics and Gynecology, Haukeland University Hospital, N5021 Bergen, Norway [2] Department of Clinical Science, Centre for Cancer Biomarkers, University of Bergen, N5020 Bergen, Norway [3].
Meyerson M; 1] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA [2] The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA [3] Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA [4].
Pokaż więcej
Źródło:
Nature [Nature] 2014 Feb 20; Vol. 506 (7488), pp. 371-5. Date of Electronic Publication: 2013 Dec 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Genome, Human/*genetics
Mutation/*genetics
Uterine Cervical Neoplasms/*genetics
Adenocarcinoma/genetics ; Adenocarcinoma/virology ; Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/virology ; Case-Control Studies ; Cell Cycle Proteins/genetics ; Core Binding Factor beta Subunit/genetics ; DNA Copy Number Variations/genetics ; DNA Mutational Analysis ; DNA-Binding Proteins/genetics ; E1A-Associated p300 Protein/genetics ; Exome/genetics ; F-Box Proteins/genetics ; F-Box-WD Repeat-Containing Protein 7 ; Female ; Gene Expression Regulation, Neoplastic/genetics ; Genomics ; HLA-B Antigens/genetics ; Humans ; Mitogen-Activated Protein Kinase 1/genetics ; NF-E2-Related Factor 2/genetics ; Papillomaviridae/genetics ; Papillomaviridae/physiology ; Papillomavirus Infections/genetics ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins c-ets ; Receptor, ErbB-2/genetics ; Transcription Factors/genetics ; Transcriptome/genetics ; Tumor Suppressor Protein p53/genetics ; Ubiquitin-Protein Ligases/genetics ; Uterine Cervical Neoplasms/virology ; Virus Integration/genetics
Czasopismo naukowe
Tytuł:
DNA methylation of alternative promoters directs tissue specific expression of Epac2 isoforms.
Autorzy:
Hoivik EA; Department of Biomedicine, University of Bergen, Bergen, Norway.
Witsoe SL
Bergheim IR
Xu Y
Jakobsson I
Tengholm A
Doskeland SO
Bakke M
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Źródło:
PloS one [PLoS One] 2013 Jul 04; Vol. 8 (7), pp. e67925. Date of Electronic Publication: 2013 Jul 04 (Print Publication: 2013).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
DNA Methylation*
Epigenesis, Genetic*
Promoter Regions, Genetic*
Guanine Nucleotide Exchange Factors/*genetics
Hepatocytes/*metabolism
Animals ; Female ; Genes, Reporter ; Guanine Nucleotide Exchange Factors/metabolism ; Hepatocytes/cytology ; Luciferases/genetics ; Male ; Mice ; Mice, Inbred C57BL ; Organ Specificity ; Primary Cell Culture ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Signal Transduction ; Transcription, Genetic
Czasopismo naukowe
Tytuł:
KRAS gene amplification and overexpression but not mutation associates with aggressive and metastatic endometrial cancer.
Autorzy:
Birkeland E; Department of Obstetrics and Gynaecology, Haukeland University Hospital, Bergen 5021, Norway.
Wik E
Mjøs S
Hoivik EA
Trovik J
Werner HM
Kusonmano K
Petersen K
Raeder MB
Holst F
Øyan AM
Kalland KH
Akslen LA
Simon R
Krakstad C
Salvesen HB
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Źródło:
British journal of cancer [Br J Cancer] 2012 Dec 04; Vol. 107 (12), pp. 1997-2004. Date of Electronic Publication: 2012 Oct 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Amplification*
Gene Dosage*
Mutation*
Endometrial Neoplasms/*genetics
Endometrial Neoplasms/*pathology
Genes, ras/*genetics
Proto-Oncogene Proteins/*genetics
ras Proteins/*genetics
Adult ; Aged ; Endometrial Neoplasms/metabolism ; Endometrial Neoplasms/mortality ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Immunohistochemistry ; Lymphatic Metastasis ; Middle Aged ; Neoplasm Grading ; Oligonucleotide Array Sequence Analysis ; Phenotype ; Polymerase Chain Reaction ; Predictive Value of Tests ; Prognosis ; Proto-Oncogene Proteins p21(ras) ; Sequence Analysis, DNA ; Tissue Array Analysis ; Up-Regulation
Czasopismo naukowe
Tytuł:
High-throughput mutation profiling of primary and metastatic endometrial cancers identifies KRAS, FGFR2 and PIK3CA to be frequently mutated.
Autorzy:
Krakstad C; Department of Clinical Medicine, University of Bergen, Bergen, Norway. />Birkeland E
Seidel D
Kusonmano K
Petersen K
Mjøs S
Hoivik EA
Wik E
Halle MK
Øyan AM
Kalland KH
Werner HM
Trovik J
Salvesen H
Pokaż więcej
Źródło:
PloS one [PLoS One] 2012; Vol. 7 (12), pp. e52795. Date of Electronic Publication: 2012 Dec 27.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Carcinoma/*genetics
Endometrial Neoplasms/*genetics
Phosphatidylinositol 3-Kinases/*genetics
Proto-Oncogene Proteins/*genetics
Receptor, Fibroblast Growth Factor, Type 2/*genetics
ras Proteins/*genetics
Aged ; Carcinoma/secondary ; Cell Line, Tumor ; Class I Phosphatidylinositol 3-Kinases ; Cluster Analysis ; DNA Mutational Analysis ; Endometrial Neoplasms/pathology ; Female ; Gene Frequency ; Genetic Association Studies ; Genetic Linkage ; High-Throughput Nucleotide Sequencing ; Humans ; Mutation, Missense ; Oligonucleotide Array Sequence Analysis ; Proto-Oncogene Proteins p21(ras) ; Transcriptome
Czasopismo naukowe
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