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Wyszukujesz frazę ""Homeodomain Proteins"" wg kryterium: Temat


Tytuł :
Expression of ISL1 and its partners in prostate cancer progression and neuroendocrine differentiation.
Autorzy :
Alshalalfa M; The Prostate Cancer Center, Calgary, AB, Canada.
Abou-Ouf H; Department of Pathology and Laboratory Medicine, University of Calgary Cumming School of Medicine, Calgary, AB, Canada.; Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, AB, Canada.
Davicioni E; Decipher Biosciences Inc, Vancouver, BC, Canada.
Karnes RJ; Department of Urology, Mayo Clinic, Rochester, MN, USA.
Alhajj R; Department of Computer Science, University of Calgary, Calgary, AB, Canada.
Bismar TA; The Prostate Cancer Center, Calgary, AB, Canada. .; Department of Pathology and Laboratory Medicine, University of Calgary Cumming School of Medicine, Calgary, AB, Canada. .; Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, AB, Canada. .; Rockyview General Hospital, Department of Pathology & Laboratory Medicine, Calgary, AB, T2V 1P9, Canada. .
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Źródło :
Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2021 Aug; Vol. 147 (8), pp. 2223-2231. Date of Electronic Publication: 2021 Apr 16.
Typ publikacji :
Journal Article
MeSH Terms :
Homeodomain Proteins/*genetics
LIM-Homeodomain Proteins/*genetics
Neuroendocrine Tumors/*genetics
Prostatic Neoplasms/*genetics
Transcription Factors/*genetics
Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Cell Differentiation/genetics ; Cell Line, Tumor ; Disease Progression ; Drug Resistance, Neoplasm/genetics ; Gene Expression Regulation, Neoplastic ; Homeodomain Proteins/metabolism ; Humans ; LIM-Homeodomain Proteins/metabolism ; Male ; Myeloid Ecotropic Viral Integration Site 1 Protein/genetics ; Myeloid Ecotropic Viral Integration Site 1 Protein/metabolism ; Neuroendocrine Tumors/pathology ; Prostatic Neoplasms/pathology ; Protein Binding ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
Two naturally derived small molecules disrupt the sineoculis homeobox homolog 1-eyes absent homolog 1 (SIX1-EYA1) interaction to inhibit colorectal cancer cell growth.
Autorzy :
Wu J; Department of Integrated Traditional and Western Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China.
Huang B; Department of Vascular Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China.
He HB; Department of Integrated Traditional and Western Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China.
Lu WZ; Department of Integrated Traditional and Western Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China.
Wang WG; Department of Integrated Traditional and Western Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China.
Liu H; Department of Integrated Traditional and Western Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China.
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Źródło :
Chinese medical journal [Chin Med J (Engl)] 2021 Sep 23; Vol. 134 (19), pp. 2340-2352. Date of Electronic Publication: 2021 Sep 23.
Typ publikacji :
Journal Article
MeSH Terms :
Colorectal Neoplasms*/drug therapy
Colorectal Neoplasms*/genetics
Homeodomain Proteins*/genetics
Homeodomain Proteins*/metabolism
Animals ; Cell Line, Tumor ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Genes, Homeobox ; Humans ; Intracellular Signaling Peptides and Proteins ; Mice ; Mice, Nude ; Nuclear Proteins/genetics ; Protein Tyrosine Phosphatases/genetics
Czasopismo naukowe
Tytuł :
The intervening domain is required for DNA-binding and functional identity of plant MADS transcription factors.
Autorzy :
Lai X; Laboratoire Physiologie Cellulaire et Végétale, Université Grenoble Alpes, CNRS, CEA, INRAE, IRIG-DBSCI-LPCV, Grenoble, France.
Vega-Léon R; Plant Cell and Molecular Biology, Institute of Biology, Humboldt-Universität zu Berlin, Berlin, Germany.
Hugouvieux V; Laboratoire Physiologie Cellulaire et Végétale, Université Grenoble Alpes, CNRS, CEA, INRAE, IRIG-DBSCI-LPCV, Grenoble, France. .
Blanc-Mathieu R; Laboratoire Physiologie Cellulaire et Végétale, Université Grenoble Alpes, CNRS, CEA, INRAE, IRIG-DBSCI-LPCV, Grenoble, France.
van der Wal F; Bioscience, Wageningen Plant Research, Wageningen University and Research, Wageningen, The Netherlands.
Lucas J; Laboratoire Physiologie Cellulaire et Végétale, Université Grenoble Alpes, CNRS, CEA, INRAE, IRIG-DBSCI-LPCV, Grenoble, France.
Silva CS; Laboratoire Physiologie Cellulaire et Végétale, Université Grenoble Alpes, CNRS, CEA, INRAE, IRIG-DBSCI-LPCV, Grenoble, France.; European Molecular Biology Laboratory, Grenoble, France.
Jourdain A; Laboratoire Physiologie Cellulaire et Végétale, Université Grenoble Alpes, CNRS, CEA, INRAE, IRIG-DBSCI-LPCV, Grenoble, France.
Muino JM; Systems Biology of Gene Regulation, Institute of Biology, Humboldt-Universität zu Berlin, Berlin, Germany.
Nanao MH; European Synchrotron Radiation Facility, Structural Biology Group, Grenoble, France.
Immink R; Bioscience, Wageningen Plant Research, Wageningen University and Research, Wageningen, The Netherlands.; Laboratory of Molecular Biology, Wageningen University and Research, Wageningen, The Netherlands.
Kaufmann K; Plant Cell and Molecular Biology, Institute of Biology, Humboldt-Universität zu Berlin, Berlin, Germany.
Parcy F; Laboratoire Physiologie Cellulaire et Végétale, Université Grenoble Alpes, CNRS, CEA, INRAE, IRIG-DBSCI-LPCV, Grenoble, France.
Smaczniak C; Plant Cell and Molecular Biology, Institute of Biology, Humboldt-Universität zu Berlin, Berlin, Germany. .
Zubieta C; Laboratoire Physiologie Cellulaire et Végétale, Université Grenoble Alpes, CNRS, CEA, INRAE, IRIG-DBSCI-LPCV, Grenoble, France. .
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Źródło :
Nature communications [Nat Commun] 2021 Aug 06; Vol. 12 (1), pp. 4760. Date of Electronic Publication: 2021 Aug 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA-Binding Proteins/*chemistry
Homeodomain Proteins/*chemistry
Transcription Factors/*chemistry
AGAMOUS Protein, Arabidopsis/chemistry ; AGAMOUS Protein, Arabidopsis/genetics ; Arabidopsis/genetics ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; DNA-Binding Proteins/metabolism ; Flowers ; Gene Expression Regulation, Plant ; Homeodomain Proteins/genetics ; Homeodomain Proteins/metabolism ; MADS Domain Proteins/metabolism ; Phenotype ; Protein Interaction Domains and Motifs ; Transcription Factors/genetics ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
A Novel Splice Variant of the Inhibitor of Growth 3 Lacks the Plant Homeodomain and Regulates Epithelial-Mesenchymal Transition in Prostate Cancer Cells.
Autorzy :
Melekhova A; Institute of Human Genetics, Jena University Hospital, 07740 Jena, Germany.
Leeder M; Department of Adult and Pediatric Urology, Jena University Hospital, 07743 Jena, Germany.
Pungsrinont T; Institute of Human Genetics, Jena University Hospital, 07740 Jena, Germany.
Schmäche T; Institute of Human Genetics, Jena University Hospital, 07740 Jena, Germany.; Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.; National Center for Tumor Diseases (NCT/UCC), 01307 Dresden, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany.
Kallenbach J; Institute of Human Genetics, Jena University Hospital, 07740 Jena, Germany.
Ehsani M; Institute of Human Genetics, Jena University Hospital, 07740 Jena, Germany.
Mirzakhani K; Institute of Human Genetics, Jena University Hospital, 07740 Jena, Germany.
Rasa SMM; Leibniz Institute on Aging, 07745 Jena, Germany.
Neri F; Leibniz Institute on Aging, 07745 Jena, Germany.
Baniahmad A; Institute of Human Genetics, Jena University Hospital, 07740 Jena, Germany.
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Źródło :
Biomolecules [Biomolecules] 2021 Aug 04; Vol. 11 (8). Date of Electronic Publication: 2021 Aug 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic*
RNA Splicing*
Epithelial-Mesenchymal Transition/*genetics
Homeodomain Proteins/*genetics
Prostatic Neoplasms/*genetics
Tumor Suppressor Proteins/*genetics
Cell Line, Tumor ; Cell Proliferation ; Cyclin-Dependent Kinase Inhibitor p16/genetics ; Cyclin-Dependent Kinase Inhibitor p16/metabolism ; Cyclin-Dependent Kinase Inhibitor p21/genetics ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Histones/genetics ; Histones/metabolism ; Homeodomain Proteins/antagonists & inhibitors ; Homeodomain Proteins/metabolism ; Humans ; Male ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/surgery ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Signal Transduction ; Snail Family Transcription Factors/genetics ; Snail Family Transcription Factors/metabolism ; Spheroids, Cellular/metabolism ; Spheroids, Cellular/pathology ; TATA-Box Binding Protein/genetics ; TATA-Box Binding Protein/metabolism ; Tumor Suppressor Proteins/antagonists & inhibitors ; Tumor Suppressor Proteins/metabolism ; Twist-Related Protein 1/genetics ; Twist-Related Protein 1/metabolism ; Zinc Finger E-box-Binding Homeobox 1/genetics ; Zinc Finger E-box-Binding Homeobox 1/metabolism
Czasopismo naukowe
Tytuł :
Norrie disease protein is essential for cochlear hair cell maturation.
Autorzy :
Hayashi Y; Department of Otolaryngology, Harvard Medical School, Boston, MA 02115.; Eaton Peabody Laboratory, Massachusetts Eye and Ear, Boston, MA 02114.
Chiang H; Department of Otolaryngology, Harvard Medical School, Boston, MA 02115.; Eaton Peabody Laboratory, Massachusetts Eye and Ear, Boston, MA 02114.
Tian C; Department of Otolaryngology, Harvard Medical School, Boston, MA 02115.; Eaton Peabody Laboratory, Massachusetts Eye and Ear, Boston, MA 02114.
Indzhykulian AA; Department of Otolaryngology, Harvard Medical School, Boston, MA 02115.; Eaton Peabody Laboratory, Massachusetts Eye and Ear, Boston, MA 02114.; Program in Speech and Hearing Bioscience and Technology, Harvard Medical School, Boston, MA 02115.
Edge ASB; Department of Otolaryngology, Harvard Medical School, Boston, MA 02115; .; Eaton Peabody Laboratory, Massachusetts Eye and Ear, Boston, MA 02114.; Program in Speech and Hearing Bioscience and Technology, Harvard Medical School, Boston, MA 02115.; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02139.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Sep 28; Vol. 118 (39).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA-Binding Proteins/*metabolism
Eye Proteins/*physiology
Hair Cells, Auditory/*pathology
Hearing Loss/*pathology
Homeodomain Proteins/*metabolism
Nerve Tissue Proteins/*physiology
Transcription Factor Brn-3C/*metabolism
Transcription Factors/*metabolism
Animals ; Animals, Newborn ; DNA-Binding Proteins/genetics ; Female ; Hair Cells, Auditory/metabolism ; Hearing Loss/etiology ; Hearing Loss/metabolism ; Homeodomain Proteins/genetics ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Transcription Factor Brn-3C/genetics ; Transcription Factors/genetics ; Wnt Signaling Pathway
Czasopismo naukowe
Tytuł :
Dysregulated paired related homeobox 1 impacts on hepatocellular carcinoma phenotypes.
Autorzy :
Piorońska W; Department of Medicine II, Section Molecular Hepatology, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.
Nwosu ZC; Department of Medicine II, Section Molecular Hepatology, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.; Current address: Department of Molecular and Integrative Physiology, Rogel Cancer Centre, University of Michigan, Ann Arbor, MI, 48109, USA.
Han M; Department of Medicine II, Section Molecular Hepatology, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.; Current address: Department of Internal Medicine, the Second Hospital of Dalian Medical University, Shahekou District, Dalian City, Liaoning Province, China.
Büttner M; The Metabolomics Core Technology Platform of the University of Heidelberg, Im Neuenheimer Feld 360, 69120, Heidelberg, Germany.
Ebert MP; Department of Medicine II, Section Molecular Hepatology, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.
Dooley S; Department of Medicine II, Section Molecular Hepatology, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.
Meyer C; Department of Medicine II, Section Molecular Hepatology, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany. .
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Źródło :
BMC cancer [BMC Cancer] 2021 Sep 08; Vol. 21 (1), pp. 1006. Date of Electronic Publication: 2021 Sep 08.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Metabolome*
Biomarkers, Tumor/*metabolism
Carcinoma, Hepatocellular/*pathology
Homeodomain Proteins/*metabolism
Liver Neoplasms/*pathology
Biomarkers, Tumor/genetics ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/metabolism ; Cell Proliferation ; Epithelial-Mesenchymal Transition ; Homeodomain Proteins/genetics ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/metabolism ; Phenotype ; Prognosis ; Survival Rate ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Transcriptional network involving ERG and AR orchestrates Distal-less homeobox-1 mediated prostate cancer progression.
Autorzy :
Goel S; Molecular Oncology Laboratory, Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, Kanpur, U.P., India.
Bhatia V; Molecular Oncology Laboratory, Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, Kanpur, U.P., India.
Kundu S; Molecular Oncology Laboratory, Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, Kanpur, U.P., India.
Biswas T; Molecular Oncology Laboratory, Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, Kanpur, U.P., India.
Carskadon S; Vattikuti Urology Institute, Department of Urology, Henry Ford Health System, Detroit, MI, USA.
Gupta N; Department of Pathology, Henry Ford Health System, Detroit, MI, USA.
Asim M; Department of Clinical and Experimental Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK.
Morrissey C; Department of Urology, University of Washington, Seattle, WA, USA.
Palanisamy N; Vattikuti Urology Institute, Department of Urology, Henry Ford Health System, Detroit, MI, USA.
Ateeq B; Molecular Oncology Laboratory, Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, Kanpur, U.P., India. .; The Mehta Family Center for Engineering in Medicine, Indian Institute of Technology Kanpur, Kanpur, U.P., India. .
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Źródło :
Nature communications [Nat Commun] 2021 Sep 07; Vol. 12 (1), pp. 5325. Date of Electronic Publication: 2021 Sep 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Transcription, Genetic*
Homeodomain Proteins/*genetics
Prostatic Neoplasms/*genetics
Receptors, Androgen/*genetics
Transcription Factors/*genetics
Androgen Antagonists/pharmacology ; Animals ; Azepines/pharmacology ; Cell Line, Tumor ; Disease Progression ; Gene Expression Regulation, Neoplastic ; Hepatocyte Nuclear Factor 3-alpha/genetics ; Hepatocyte Nuclear Factor 3-alpha/metabolism ; Homeodomain Proteins/metabolism ; Humans ; Male ; Mice ; Mice, Knockout ; Mice, SCID ; Neoplasm Metastasis ; Oncogene Proteins, Fusion/genetics ; Oncogene Proteins, Fusion/metabolism ; Promoter Regions, Genetic ; Prostate/drug effects ; Prostate/metabolism ; Prostate/pathology ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/mortality ; Prostatic Neoplasms/pathology ; Protein Binding ; Receptors, Androgen/metabolism ; Serine Endopeptidases/genetics ; Serine Endopeptidases/metabolism ; Signal Transduction ; Survival Analysis ; Transcription Factors/metabolism ; Transcriptional Regulator ERG/genetics ; Transcriptional Regulator ERG/metabolism ; Triazoles/pharmacology ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Phytochrome B triggers light-dependent chromatin remodelling through the PRC2-associated PHD finger protein VIL1.
Autorzy :
Kim J; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.
Bordiya Y; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.
Kathare PK; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.
Zhao B; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.
Zong W; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.
Huq E; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.
Sung S; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA. .
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Źródło :
Nature plants [Nat Plants] 2021 Sep; Vol. 7 (9), pp. 1213-1219. Date of Electronic Publication: 2021 Aug 05.
Typ publikacji :
Comparative Study; Letter; Research Support, N.I.H., Extramural
MeSH Terms :
Acclimatization/*genetics
Adaptation, Ocular/*genetics
Chromatin Assembly and Disassembly/*genetics
Homeodomain Proteins/*metabolism
Phytochrome B/*metabolism
Polycomb-Group Proteins/*metabolism
Stress, Physiological/*genetics
Arabidopsis/genetics ; Chromatin Assembly and Disassembly/physiology ; Gene Expression Regulation, Plant ; Genes, Plant ; Genetic Variation ; Genotype ; Homeodomain Proteins/genetics ; Mutation ; PHD Zinc Fingers/genetics ; PHD Zinc Fingers/physiology ; Phytochrome B/genetics ; Polycomb-Group Proteins/genetics ; Stress, Physiological/physiology
Raport
Tytuł :
Genetic analysis of primary open-angle glaucoma-related risk alleles in a Korean population: the GLAU-GENDISK study.
Autorzy :
Kim YW; Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.; Department of Ophthalmology, Seoul National University Hospital, Seoul, Korea.
Lee YH; Department of Public Health Sciences, Seoul National University, Seoul, Korea.
Kim JS; Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.; Department of Ophthalmology, Chungnam National University Sejong Hospital, Sejong, Korea.
Lee J; Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.; Department of Ophthalmology, Hallym University Chuncheon Sacred Heart Hospital, Chuncheon, Korea.
Kim YJ; Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.
Cheong HS; Department of Genetic Epidemiology, SNP Genetics, Inc., Seoul, Korea.
Kim SH; Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.; Department of Ophthalmology, Seoul National University Boramae Medical Center, Seoul, Korea.
Park KH; Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.; Department of Ophthalmology, Seoul National University Hospital, Seoul, Korea.
Kim DM; Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.
Choi HJ; Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.; Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Korea.
Jeoung JW; Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea .; Department of Ophthalmology, Seoul National University Hospital, Seoul, Korea.
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Źródło :
The British journal of ophthalmology [Br J Ophthalmol] 2021 Sep; Vol. 105 (9), pp. 1307-1312. Date of Electronic Publication: 2020 Sep 15.
Typ publikacji :
Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Genetic Predisposition to Disease*
Polymorphism, Single Nucleotide*
DNA/*genetics
Glaucoma, Open-Angle/*genetics
Homeodomain Proteins/*genetics
Intraocular Pressure/*physiology
Trans-Activators/*genetics
Alleles ; Female ; Follow-Up Studies ; Genotype ; Glaucoma, Open-Angle/epidemiology ; Glaucoma, Open-Angle/physiopathology ; Homeodomain Proteins/metabolism ; Humans ; Incidence ; Male ; Middle Aged ; Prospective Studies ; Republic of Korea/epidemiology ; Trans-Activators/metabolism
Czasopismo naukowe
Tytuł :
Genome-wide analysis of the mouse LIM gene family reveals its roles in regulating pathological cardiac hypertrophy.
Autorzy :
Wang F; Department of Cardiology, The Second Affiliated Hospital of Air Force Medical University, Xi'an, China.
Zhao J; Department of Cardiology, The Second Affiliated Hospital of Air Force Medical University, Xi'an, China.
Zhang M; Department of Cardiology, The Second Affiliated Hospital of Air Force Medical University, Xi'an, China.
Yang J; Department of Cardiology, The Second Affiliated Hospital of Air Force Medical University, Xi'an, China.
Zeng G; Department of Cardiology, The Second Affiliated Hospital of Air Force Medical University, Xi'an, China.; Department of Cardiology, Xi'an International Medical Center Hospital, Northwest University, Xi'an, China.
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Źródło :
FEBS letters [FEBS Lett] 2021 Sep; Vol. 595 (17), pp. 2271-2289. Date of Electronic Publication: 2021 Aug 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cardiomegaly/*genetics
LIM-Homeodomain Proteins/*genetics
Animals ; Cardiomegaly/pathology ; Carrier Proteins/genetics ; Cytoskeletal Proteins/genetics ; Cytoskeleton/genetics ; DNA-Binding Proteins/genetics ; Electrocardiography ; Gene Expression Regulation ; Heart/embryology ; Heart Failure/genetics ; LIM Domain Proteins/genetics ; LIM-Homeodomain Proteins/chemistry ; Male ; Mice, Inbred C57BL ; Multigene Family ; Phylogeny ; Rats
Czasopismo naukowe
Tytuł :
The Hox protein conundrum: The "specifics" of DNA binding for Hox proteins and their partners.
Autorzy :
De Kumar B; Department of Biomedical Sciences, The University of North Dakota, USA; Department of Genetics, School of Medicine, Yale University, 830, West Campus Drive, West Haven, 06516, USA. Electronic address: .
Darland DC; Department of Biology, The University of North Dakota, USA. Electronic address: .
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Źródło :
Developmental biology [Dev Biol] 2021 Sep; Vol. 477, pp. 284-292. Date of Electronic Publication: 2021 Jun 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
DNA/*metabolism
Homeodomain Proteins/*metabolism
Animals ; DNA-Binding Proteins/metabolism ; Genes, Homeobox ; Homeodomain Proteins/genetics ; Humans ; Models, Genetic ; Protein Binding
Czasopismo naukowe
Tytuł :
Upregulation of HOXC9 generates interferon-gamma resistance in gastric cancer by inhibiting the DAPK1/RIG1/STAT1 axis.
Autorzy :
Tang Y; Department of General Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, China.
Wang T; Department of Radiation Oncology, The Fourth Affiliated Hospital of China Medical University, Shenyang, China.
Yu Y; Department of Radiation Oncology, The Fourth Affiliated Hospital of China Medical University, Shenyang, China.
Yan Y; Department of General Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, China.
Wu C; Department of Radiation Oncology, The Fourth Affiliated Hospital of China Medical University, Shenyang, China.
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Źródło :
Cancer science [Cancer Sci] 2021 Sep; Vol. 112 (9), pp. 3455-3468. Date of Electronic Publication: 2021 Jul 12.
Typ publikacji :
Journal Article
MeSH Terms :
Death-Associated Protein Kinases/*metabolism
Drug Resistance, Neoplasm/*genetics
Homeodomain Proteins/*metabolism
Interferon-gamma/*pharmacology
Receptors, Retinoic Acid/*metabolism
STAT1 Transcription Factor/*metabolism
Signal Transduction/*genetics
Stomach Neoplasms/*metabolism
Up-Regulation/*genetics
Apoptosis/drug effects ; Apoptosis/genetics ; Cell Line, Tumor ; Cell Survival/drug effects ; Cell Survival/genetics ; Cohort Studies ; Databases, Genetic ; Death-Associated Protein Kinases/genetics ; Gene Knockdown Techniques ; Homeodomain Proteins/genetics ; Humans ; Immune Checkpoint Inhibitors/therapeutic use ; Melanoma/drug therapy ; Melanoma/metabolism ; Oncogenes ; Receptors, Retinoic Acid/genetics ; Signal Transduction/drug effects ; Skin Neoplasms/drug therapy ; Skin Neoplasms/metabolism ; Stomach Neoplasms/pathology ; Transfection
Czasopismo naukowe
Tytuł :
Identification of variants of ISL1 gene promoter and cellular functions in isolated ventricular septal defects.
Autorzy :
Zheng SQ; The Institute of Cardiovascular Diseases & Department of Cardiovascular Surgery, TEDA International Cardiovascular Hospital, Tianjin University & Chinese Academy of Medical Sciences, Tianjin, People's Republic of China.
Chen HX; The Institute of Cardiovascular Diseases & Department of Cardiovascular Surgery, TEDA International Cardiovascular Hospital, Tianjin University & Chinese Academy of Medical Sciences, Tianjin, People's Republic of China.
Liu XC; The Institute of Cardiovascular Diseases & Department of Cardiovascular Surgery, TEDA International Cardiovascular Hospital, Tianjin University & Chinese Academy of Medical Sciences, Tianjin, People's Republic of China.
Yang Q; The Institute of Cardiovascular Diseases & Department of Cardiovascular Surgery, TEDA International Cardiovascular Hospital, Tianjin University & Chinese Academy of Medical Sciences, Tianjin, People's Republic of China.
He GW; The Institute of Cardiovascular Diseases & Department of Cardiovascular Surgery, TEDA International Cardiovascular Hospital, Tianjin University & Chinese Academy of Medical Sciences, Tianjin, People's Republic of China.; Drug Research and Development Center, Wannan Medical College, Wuhu, People's Republic of China.; Department of Surgery, Oregon Health and Science University, Portland, Oregon.
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Źródło :
American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2021 Sep 01; Vol. 321 (3), pp. C443-C452. Date of Electronic Publication: 2021 Jul 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Polymorphism, Single Nucleotide*
Promoter Regions, Genetic*
Heart Septal Defects, Ventricular/*genetics
LIM-Homeodomain Proteins/*genetics
Transcription Factors/*genetics
Adolescent ; Asian Continental Ancestry Group ; Base Sequence ; Binding Sites ; Case-Control Studies ; Child ; Child, Preschool ; Databases, Genetic ; Female ; Gene Expression ; Genes, Reporter ; HEK293 Cells ; Heart Septal Defects, Ventricular/ethnology ; Heart Septal Defects, Ventricular/metabolism ; Heart Septal Defects, Ventricular/pathology ; Humans ; Infant ; LIM-Homeodomain Proteins/metabolism ; Luciferases/genetics ; Luciferases/metabolism ; Male ; Protein Binding ; Sequence Analysis, DNA ; Transcription Factors/metabolism ; Ventricular Septum/metabolism ; Ventricular Septum/pathology
Czasopismo naukowe
Tytuł :
Paired-like homeobox gene (PHOX2B) nonpolyalanine repeat expansion mutations (NPARMs): genotype-phenotype correlation in congenital central hypoventilation syndrome (CCHS).
Autorzy :
Zhou A; Department of Pediatrics, Division of Autonomic Medicine, Center for Autonomic Medicine in Pediatrics (CAMP), Ann & Robert H. Lurie Children's Hospital of Chicago and Stanley Manne Children's Research Institute, Chicago, IL, USA.
Rand CM; Department of Pediatrics, Division of Autonomic Medicine, Center for Autonomic Medicine in Pediatrics (CAMP), Ann & Robert H. Lurie Children's Hospital of Chicago and Stanley Manne Children's Research Institute, Chicago, IL, USA.
Hockney SM; Department of Pediatrics, Division of Autonomic Medicine, Center for Autonomic Medicine in Pediatrics (CAMP), Ann & Robert H. Lurie Children's Hospital of Chicago and Stanley Manne Children's Research Institute, Chicago, IL, USA.; Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Niewijk G; Department of Pediatrics, Division of Autonomic Medicine, Center for Autonomic Medicine in Pediatrics (CAMP), Ann & Robert H. Lurie Children's Hospital of Chicago and Stanley Manne Children's Research Institute, Chicago, IL, USA.
Reineke P; Ambry Genetics, Aliso Viejo, CA, USA.
Speare V; Ambry Genetics, Aliso Viejo, CA, USA.
Berry-Kravis EM; Departments of Pediatrics, Neurology, and Biochemistry, Molecular Diagnostics Laboratory, Rush University Medical Center, Chicago, IL, USA.
Zhou L; Departments of Pediatrics, Neurology, and Biochemistry, Molecular Diagnostics Laboratory, Rush University Medical Center, Chicago, IL, USA.
Jennings LJ; Department of Pathology, Molecular Diagnostics Laboratory, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.; Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Yu M; Department of Pathology, Molecular Diagnostics Laboratory, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.
Ceccherini I; IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Bachetti T; IRCCS Istituto Giannina Gaslini, Genoa, Italy.; Lab Neurobiologia dello Sviluppo, Dip. Scienze della Terra dell'Ambiente e della Vita (DISTAV), Università di Genova, Genova, Italy.
Pennock M; North Bristol NHS Trust, Bristol, UK.
Yap KL; Department of Pathology, Molecular Diagnostics Laboratory, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.; Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Weese-Mayer DE; Department of Pediatrics, Division of Autonomic Medicine, Center for Autonomic Medicine in Pediatrics (CAMP), Ann & Robert H. Lurie Children's Hospital of Chicago and Stanley Manne Children's Research Institute, Chicago, IL, USA. .; Northwestern University Feinberg School of Medicine, Chicago, IL, USA. .; Department of Pediatrics, Pediatric Autonomic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. .
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Źródło :
Genetics in medicine : official journal of the American College of Medical Genetics [Genet Med] 2021 Sep; Vol. 23 (9), pp. 1656-1663. Date of Electronic Publication: 2021 May 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genes, Homeobox*
Homeodomain Proteins*/genetics
Genetic Association Studies ; Humans ; Hypoventilation/congenital ; Mutation ; Sleep Apnea, Central
SCR Disease Name :
Congenital central hypoventilation syndrome
Czasopismo naukowe
Tytuł :
Nkx2-2 expressing taste cells in endoderm-derived taste papillae are committed to the type III lineage.
Autorzy :
Qin Y; School of Food Science and Bioengineering, Zhejiang Gongshang University, Hangzhou, PR China; Monell Chemical Senses Center, Philadelphia, PA, USA.
Sukumaran SK; Monell Chemical Senses Center, Philadelphia, PA, USA; Present Address: Department of Nutrition and Health Sciences, University of Nebraska- Lincoln, Lincoln, NE, USA. Electronic address: .
Margolskee RF; Monell Chemical Senses Center, Philadelphia, PA, USA.
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Źródło :
Developmental biology [Dev Biol] 2021 Sep; Vol. 477, pp. 232-240. Date of Electronic Publication: 2021 Jun 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Lineage/*physiology
Homeodomain Proteins/*physiology
Taste Buds/*embryology
Zebrafish Proteins/*physiology
Animals ; Animals, Newborn ; Antigens, Differentiation/biosynthesis ; Antigens, Differentiation/physiology ; Cell Count ; Cell Lineage/genetics ; Female ; Homeodomain Proteins/biosynthesis ; Male ; Mice ; RNA-Seq ; Taste Buds/cytology ; Taste Buds/metabolism ; Zebrafish Proteins/biosynthesis
Czasopismo naukowe
Tytuł :
A Multiplex CRISPR-Screen Identifies PLA2G4A as Prognostic Marker and Druggable Target for HOXA9 and MEIS1 Dependent AML.
Autorzy :
Hassan JJ; Institute of Experimental Hematology, Hannover Medical School, 30625 Hannover, Germany.
Lieske A; Institute of Experimental Hematology, Hannover Medical School, 30625 Hannover, Germany.; Department of Pediatric Hematology and Oncology, Hannover Medical School, 30625 Hannover, Germany.
Dörpmund N; Institute of Experimental Hematology, Hannover Medical School, 30625 Hannover, Germany.; Department of Pediatric Hematology and Oncology, Hannover Medical School, 30625 Hannover, Germany.
Klatt D; Institute of Experimental Hematology, Hannover Medical School, 30625 Hannover, Germany.
Hoffmann D; Institute of Experimental Hematology, Hannover Medical School, 30625 Hannover, Germany.
Kleppa MJ; Institute of Experimental Hematology, Hannover Medical School, 30625 Hannover, Germany.
Kustikova OS; Institute of Experimental Hematology, Hannover Medical School, 30625 Hannover, Germany.
Stahlhut M; Institute of Experimental Hematology, Hannover Medical School, 30625 Hannover, Germany.
Schwarzer A; Institute of Experimental Hematology, Hannover Medical School, 30625 Hannover, Germany.; Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, 30625 Hannover, Germany.
Schambach A; Institute of Experimental Hematology, Hannover Medical School, 30625 Hannover, Germany.; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Maetzig T; Institute of Experimental Hematology, Hannover Medical School, 30625 Hannover, Germany.; Department of Pediatric Hematology and Oncology, Hannover Medical School, 30625 Hannover, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 30; Vol. 22 (17). Date of Electronic Publication: 2021 Aug 30.
Typ publikacji :
Journal Article
MeSH Terms :
CRISPR-Cas Systems*
Gene Expression Regulation, Neoplastic*
Biomarkers, Tumor/*metabolism
Group IV Phospholipases A2/*antagonists & inhibitors
Homeodomain Proteins/*metabolism
Leukemia, Myeloid, Acute/*pathology
Myeloid Ecotropic Viral Integration Site 1 Protein/*metabolism
Apoptosis ; Biomarkers, Tumor/genetics ; Cell Proliferation ; Group IV Phospholipases A2/genetics ; High-Throughput Screening Assays ; Homeodomain Proteins/genetics ; Humans ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/metabolism ; Myeloid Ecotropic Viral Integration Site 1 Protein/genetics ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Genome-Wide Identification and Characterization of KNOTTED-Like Homeobox (KNOX) Homologs in Garlic ( Allium sativum L.) and Their Expression Profilings Responding to Exogenous Cytokinin and Gibberellin.
Autorzy :
Zhang S; College of Horticulture, Northwest A&F University, Yangling 712100, China.
Pan Y; College of Horticulture, Northwest A&F University, Yangling 712100, China.
Zhi C; College of Horticulture, Northwest A&F University, Yangling 712100, China.
Zheng Y; College of Horticulture, Northwest A&F University, Yangling 712100, China.
Wang X; College of Horticulture, Northwest A&F University, Yangling 712100, China.
Li X; College of Horticulture, Northwest A&F University, Yangling 712100, China.
Cheng Z; College of Horticulture, Northwest A&F University, Yangling 712100, China.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 26; Vol. 22 (17). Date of Electronic Publication: 2021 Aug 26.
Typ publikacji :
Journal Article
MeSH Terms :
Cytokinins/*pharmacology
Garlic/*genetics
Gibberellins/*pharmacology
Homeodomain Proteins/*genetics
Plant Proteins/*genetics
Garlic/drug effects ; Garlic/metabolism ; Homeodomain Proteins/metabolism ; Plant Proteins/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
MicroRNA-638 inhibits the progression of breast cancer through targeting HOXA9 and suppressing Wnt/β-cadherin pathway.
Autorzy :
Xu Q; Department of Oncology, Weifang People's Hospital, No. 151, Guangwen Street, Kuiwen District, Weifang, 261041, People's Republic of China.
Zhang Q; Department of Oncology, Weifang People's Hospital, No. 151, Guangwen Street, Kuiwen District, Weifang, 261041, People's Republic of China.
Dong M; Department of Oncology, Weifang People's Hospital, No. 151, Guangwen Street, Kuiwen District, Weifang, 261041, People's Republic of China.
Yu Y; Department of Oncology, Weifang People's Hospital, No. 151, Guangwen Street, Kuiwen District, Weifang, 261041, People's Republic of China. .
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Źródło :
World journal of surgical oncology [World J Surg Oncol] 2021 Aug 20; Vol. 19 (1), pp. 247. Date of Electronic Publication: 2021 Aug 20.
Typ publikacji :
Journal Article
MeSH Terms :
Breast Neoplasms*/genetics
Homeodomain Proteins*/genetics
MicroRNAs*/genetics
Cadherins/genetics ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Female ; Humans ; Prognosis
Czasopismo naukowe
Tytuł :
HOXB8 Counteracts MAPK/ERK Oncogenic Signaling in a Chicken Embryo Model of Neoplasia.
Autorzy :
Wilmerding A; Aix Marseille Université (AMU), Centre National de la Recherche Scientifique (CNRS), Institut de Biologie du Développement de Marseille (IBDM-UMR 7288), 13288 Marseille, France.
Bouteille L; Aix Marseille Université (AMU), Centre National de la Recherche Scientifique (CNRS), Institut de Biologie du Développement de Marseille (IBDM-UMR 7288), 13288 Marseille, France.
Rinaldi L; Aix Marseille Université (AMU), Centre National de la Recherche Scientifique (CNRS), Institut de Biologie du Développement de Marseille (IBDM-UMR 7288), 13288 Marseille, France.; Beth Israel Deaconess Medical Center, Department of Medicine and the Cancer Center, Division of Hematology, Harvard Initiative of RNA Medicine, Harvard Medical School, Boston, MA 02115, USA.
Caruso N; Aix Marseille Université (AMU), Centre National de la Recherche Scientifique (CNRS), Institut de Biologie du Développement de Marseille (IBDM-UMR 7288), 13288 Marseille, France.
Graba Y; Aix Marseille Université (AMU), Centre National de la Recherche Scientifique (CNRS), Institut de Biologie du Développement de Marseille (IBDM-UMR 7288), 13288 Marseille, France.
Delfini MC; Aix Marseille Université (AMU), Centre National de la Recherche Scientifique (CNRS), Institut de Biologie du Développement de Marseille (IBDM-UMR 7288), 13288 Marseille, France.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 18; Vol. 22 (16). Date of Electronic Publication: 2021 Aug 18.
Typ publikacji :
Journal Article
MeSH Terms :
Biomarkers, Tumor/*metabolism
Carcinogenesis/*pathology
Homeodomain Proteins/*metabolism
MAP Kinase Kinase 1/*metabolism
Mitogen-Activated Protein Kinase 1/*metabolism
Mitogen-Activated Protein Kinase 3/*metabolism
Neoplasms/*pathology
Animals ; Biomarkers, Tumor/genetics ; Carcinogenesis/genetics ; Carcinogenesis/metabolism ; Chick Embryo ; Chickens ; Disease Models, Animal ; Gene Expression Regulation, Neoplastic ; Homeodomain Proteins/genetics ; Humans ; MAP Kinase Kinase 1/genetics ; Mitogen-Activated Protein Kinase 1/genetics ; Mitogen-Activated Protein Kinase 3/genetics ; Neoplasms/etiology ; Neoplasms/metabolism ; Prognosis ; Survival Rate ; Transcriptome
Czasopismo naukowe
Tytuł :
Mesomelic dysplasias associated with the HOXD locus are caused by regulatory reallocations.
Autorzy :
Bolt CC; School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland. .
Lopez-Delisle L; School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Mascrez B; Department of Genetics and Evolution, University of Geneva, Geneva, Switzerland.
Duboule D; School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland. .; Department of Genetics and Evolution, University of Geneva, Geneva, Switzerland. .; Collège de France, Paris, France. .
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Źródło :
Nature communications [Nat Commun] 2021 Aug 18; Vol. 12 (1), pp. 5013. Date of Electronic Publication: 2021 Aug 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Abnormalities, Multiple/*genetics
Bone Diseases, Developmental/*genetics
Homeodomain Proteins/*genetics
Limb Deformities, Congenital/*genetics
Transcription Factors/*genetics
Abnormalities, Multiple/embryology ; Abnormalities, Multiple/metabolism ; Animals ; Bone Diseases, Developmental/embryology ; Bone Diseases, Developmental/metabolism ; Disease Models, Animal ; Female ; Gene Deletion ; Homeodomain Proteins/metabolism ; Humans ; Limb Deformities, Congenital/embryology ; Limb Deformities, Congenital/metabolism ; Loss of Function Mutation ; Male ; Mice, Inbred C57BL ; Multigene Family ; Transcription Factors/metabolism
SCR Disease Name :
Mesomelic Limb Shortening and Bowing
Czasopismo naukowe

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