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Tytuł:
RAD51AP1 regulates ALT-HDR through chromatin-directed homeostasis of TERRA.
Autorzy:
Kaminski N; Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
Wondisford AR; Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
Kwon Y; Department of Biochemistry and Structural Biology, University of Texas Health Science Center, San Antonio, TX, USA.
Lynskey ML; Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
Bhargava R; Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
Barroso-González J; Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
García-Expósito L; Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
He B; Department of Biochemistry and Structural Biology, University of Texas Health Science Center, San Antonio, TX, USA; Department of Thoracic Surgery, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Xu M; Department of Biological Sciences, Mellon College of Science, Carnegie Mellon University, Pittsburgh, PA, USA.
Mellacheruvu D; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA; Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI, USA.
Watkins SC; Department of Cell Biology, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
Modesti M; Cancer Research Center of Marseille, CNRS UMR7258, Inserm UMR1068, Aix Marseille Université U105, Institut Paoli Calmettes, 27 Boulevard Lei Roure CS30059, 13273 Marseille Cedex 09, France.
Miller KM; Department of Molecular Biosciences, Institute for Cellular and Molecular Biology, The University of Texas at Austin, 2506 Speedway, Austin, TX 78712, USA.
Nesvizhskii AI; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA; Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI, USA.
Zhang H; Department of Biological Sciences, Mellon College of Science, Carnegie Mellon University, Pittsburgh, PA, USA.
Sung P; Department of Biochemistry and Structural Biology, University of Texas Health Science Center, San Antonio, TX, USA.
O'Sullivan RJ; Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: .
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Źródło:
Molecular cell [Mol Cell] 2022 Nov 03; Vol. 82 (21), pp. 4001-4017.e7. Date of Electronic Publication: 2022 Oct 19.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Telomere Homeostasis*
RNA, Long Noncoding*/genetics
Chromatin/genetics ; Proteomics ; Telomere/genetics ; Telomere/metabolism ; Homeostasis
Czasopismo naukowe
Szczegóły
Tytuł:
Emerging polyfluorinated compound Nafion by-product 2 disturbs intestinal homeostasis in zebrafish (Danio rerio).
Autorzy:
Gui W; Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Guo H; Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
Chen X; Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
Wang J; Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
Guo Y; Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.
Zhang H; Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
Zhou X; Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Zhao Y; State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants, School of Environmental Sciences and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.
Dai J; Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants, School of Environmental Sciences and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China. Electronic address: .
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Źródło:
Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2023 Jan 01; Vol. 249, pp. 114368. Date of Electronic Publication: 2022 Dec 09.
Typ publikacji:
Journal Article
MeSH Terms:
Fluorocarbon Polymers*/toxicity
Homeostasis*/drug effects
Intestines*/drug effects
Water Pollutants, Chemical*/toxicity
Animals ; Humans ; Embryo, Nonmammalian ; Zebrafish
Czasopismo naukowe
Szczegóły
Tytuł:
Causes and consequences of telomere lengthening in a wild vertebrate population.
Autorzy:
Brown TJ; School of Biological Sciences, University of East Anglia, Norwich, UK.
Spurgin LG; School of Biological Sciences, University of East Anglia, Norwich, UK.
Dugdale HL; Behavioural and Physiological Ecology, Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, The Netherlands.
Komdeur J; Behavioural and Physiological Ecology, Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, The Netherlands.
Burke T; Department of Animal and Plant Sciences, University of Sheffield, Sheffield, UK.
Richardson DS; School of Biological Sciences, University of East Anglia, Norwich, UK.; Nature Seychelles, Victoria, Mahé, Seychelles.
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Źródło:
Molecular ecology [Mol Ecol] 2022 Dec; Vol. 31 (23), pp. 5933-5945. Date of Electronic Publication: 2021 Jul 23.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Telomere Homeostasis*
Vertebrates*
Humans ; Animals ; Male ; Adult ; Female ; Telomere Shortening/genetics ; Biological Evolution ; Telomere/genetics
Czasopismo naukowe
Szczegóły
Tytuł:
TPP1 promoter mutations cooperate with TERT promoter mutations to lengthen telomeres in melanoma.
Autorzy:
Chun-On P; Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, Division of Pulmonary, Allergy, and Critical Care Medicine, Pittsburgh, PA, USA.; Environmental and Occupational Health Department, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.; Faculty of Medicine and Public Health, Princess Srisavangavadhana College of Medicine, Chulabhorn Royal Academy, Bangkok, Thailand.
Hinchie AM; Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, Division of Pulmonary, Allergy, and Critical Care Medicine, Pittsburgh, PA, USA.
Beale HC; UC Santa Cruz Genomics Institute, University of California, Santa Cruz, CA, USA.; Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, CA, USA.
Gil Silva AA; Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, Division of Pulmonary, Allergy, and Critical Care Medicine, Pittsburgh, PA, USA.
Rush E; University of Pittsburgh Medical Center, Hillman Cancer Institute, Pittsburgh, PA, USA.
Sander C; University of Pittsburgh Medical Center, Hillman Cancer Institute, Pittsburgh, PA, USA.
Connelly CJ; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Seynnaeve BKN; University of Pittsburgh Medical Center, Hillman Cancer Institute, Pittsburgh, PA, USA.; Department of Pediatrics, Division of Pediatric Hematology/Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Kirkwood JM; University of Pittsburgh Medical Center, Hillman Cancer Institute, Pittsburgh, PA, USA.
Vaske OM; UC Santa Cruz Genomics Institute, University of California, Santa Cruz, CA, USA.; Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, CA, USA.
Greider CW; UC Santa Cruz Genomics Institute, University of California, Santa Cruz, CA, USA.; Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, CA, USA.; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Alder JK; Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, Division of Pulmonary, Allergy, and Critical Care Medicine, Pittsburgh, PA, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2022 Nov 11; Vol. 378 (6620), pp. 664-668. Date of Electronic Publication: 2022 Nov 10.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Melanoma*/genetics
Promoter Regions, Genetic*/genetics
Shelterin Complex*/genetics
Skin Neoplasms*/genetics
Telomerase*/genetics
Telomere Homeostasis*/genetics
Telomere-Binding Proteins*/genetics
Humans ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Mutation ; Telomere/genetics ; Telomere/metabolism ; Transcriptional Activation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
TERRA and RAD51AP1 at the R&D-loop department of ALT telomeres.
Autorzy:
Decottignies A; Genetic and Epigenetic Alterations of Genomes, Telomere Research Group, de Duve Institute, UCLouvain, Brussels, Belgium. Electronic address: .
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Źródło:
Molecular cell [Mol Cell] 2022 Nov 03; Vol. 82 (21), pp. 3963-3965.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Comment
MeSH Terms:
Telomere Homeostasis*
RNA, Long Noncoding*/genetics
Telomere/genetics ; R-Loop Structures ; Chromatin
Czasopismo naukowe
Szczegóły
Tytuł:
Homeostases of epidermis and hair follicle, and development of basal cell carcinoma.
Autorzy:
Jaiswal A; Department of Chemical Engineering, Indian Institute of Technology Kanpur, Kanpur 208016, India.
Singh R; Department of Chemical Engineering, Indian Institute of Technology Kanpur, Kanpur 208016, India. Electronic address: .
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Źródło:
Biochimica et biophysica acta. Reviews on cancer [Biochim Biophys Acta Rev Cancer] 2022 Sep; Vol. 1877 (5), pp. 188795. Date of Electronic Publication: 2022 Sep 09.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Carcinoma, Basal Cell*/genetics
Carcinoma, Basal Cell*/metabolism
Homeostasis*
Skin Neoplasms*/genetics
Skin Neoplasms*/metabolism
Epidermis/metabolism ; Hair Follicle/metabolism ; Hedgehog Proteins/metabolism ; Humans
Czasopismo naukowe
Szczegóły
Tytuł:
Long noncoding RNA uc.230/CUG-binding protein 1 axis sustains intestinal epithelial homeostasis and response to tissue injury.
Autorzy:
Yu TX; Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Kalakonda S; Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Liu X; Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Han N; Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Chung HK; Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Xiao L; Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.; Baltimore Veterans Affairs Medical Center, Baltimore, Maryland, USA.
Rao JN; Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.; Baltimore Veterans Affairs Medical Center, Baltimore, Maryland, USA.
He TC; Department of Surgery, The University of Chicago Medical Center, Chicago, Illinois, USA.
Raufman JP; Baltimore Veterans Affairs Medical Center, Baltimore, Maryland, USA.; Department of Medicine and.
Wang JY; Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.; Baltimore Veterans Affairs Medical Center, Baltimore, Maryland, USA.; Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
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Źródło:
JCI insight [JCI Insight] 2022 Oct 10; Vol. 7 (19). Date of Electronic Publication: 2022 Oct 10.
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural
MeSH Terms:
CELF1 Protein*/genetics
CELF1 Protein*/immunology
Colitis*/genetics
Colitis*/immunology
Homeostasis*/genetics
Homeostasis*/immunology
Intestinal Mucosa*/immunology
RNA, Long Noncoding*/genetics
RNA, Long Noncoding*/immunology
Wound Healing*/genetics
Wound Healing*/immunology
Animals ; Apoptosis ; Mice ; MicroRNAs/genetics ; MicroRNAs/immunology ; RNA, Messenger/genetics ; RNA, Messenger/immunology ; Wounds and Injuries/genetics ; Wounds and Injuries/immunology
Czasopismo naukowe
Szczegóły
Tytuł:
A conserved role of bam in maintaining metabolic homeostasis via regulating intestinal microbiota in Drosophila .
Autorzy:
Wang J; Anhui Agricultural University, Hefei, China.
Zhu Y; Anhui Agricultural University, Hefei, China.
Zhang C; Anhui Agricultural University, Hefei, China.
Duan R; Anhui Agricultural University, Hefei, China.
Kong F; Anhui Agricultural University, Hefei, China.
Zheng X; Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, China.
Hua Y; Anhui Agricultural University, Hefei, China.
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Źródło:
PeerJ [PeerJ] 2022 Oct 10; Vol. 10, pp. e14145. Date of Electronic Publication: 2022 Oct 10 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Drosophila*/genetics
Drosophila Proteins*/genetics
Gastrointestinal Microbiome*/genetics
Homeostasis*/genetics
Animals ; Female ; Mice ; Cell Differentiation/genetics
Czasopismo naukowe
Szczegóły
Tytuł:
Hepatic p53 is regulated by transcription factor FOXO1 and acutely controls glycogen homeostasis.
Autorzy:
Oster M; Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Institute of Pharmacology, Cardiovascular Metabolic Renal (CMR)-Research Center, Berlin, Germany.
Galhuber M; Division of Cell Biology, Histology and Embryology, Gottfried Schatz Research Center for Cell Signaling, Metabolism & Aging, Medical University of Graz, Graz, Austria.
Krstic J; Division of Cell Biology, Histology and Embryology, Gottfried Schatz Research Center for Cell Signaling, Metabolism & Aging, Medical University of Graz, Graz, Austria.
Steinhoff JS; Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Institute of Pharmacology, Cardiovascular Metabolic Renal (CMR)-Research Center, Berlin, Germany.
Lenihan-Geels G; Department of Adipocyte Development and Nutrition, German Institute of Human Nutrition, Nuthetal, Germany.
Wulff S; Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Institute of Pharmacology, Cardiovascular Metabolic Renal (CMR)-Research Center, Berlin, Germany.
Kiefer MF; Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Institute of Pharmacology, Cardiovascular Metabolic Renal (CMR)-Research Center, Berlin, Germany.
Petricek KM; Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Institute of Pharmacology, Cardiovascular Metabolic Renal (CMR)-Research Center, Berlin, Germany.
Wowro SJ; Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Institute of Pharmacology, Cardiovascular Metabolic Renal (CMR)-Research Center, Berlin, Germany.
Flores RE; Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Institute of Pharmacology, Cardiovascular Metabolic Renal (CMR)-Research Center, Berlin, Germany.
Yang N; Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Institute of Pharmacology, Cardiovascular Metabolic Renal (CMR)-Research Center, Berlin, Germany.
Li C; Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Institute of Pharmacology, Cardiovascular Metabolic Renal (CMR)-Research Center, Berlin, Germany.
Meng Y; Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Institute of Pharmacology, Cardiovascular Metabolic Renal (CMR)-Research Center, Berlin, Germany.
Reinisch I; Division of Cell Biology, Histology and Embryology, Gottfried Schatz Research Center for Cell Signaling, Metabolism & Aging, Medical University of Graz, Graz, Austria.
Sommerfeld M; Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Institute of Pharmacology, Cardiovascular Metabolic Renal (CMR)-Research Center, Berlin, Germany.
Weger S; Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Institute of Virology, Campus Benjamin Franklin, Berlin, Germany.
Habisch H; Institute of Molecular Biology and Biochemistry, Medical University Graz, Graz, Austria.
Madl T; Institute of Molecular Biology and Biochemistry, Medical University Graz, Graz, Austria.
Schulz TJ; Department of Adipocyte Development and Nutrition, German Institute of Human Nutrition, Nuthetal, Germany; German Center for Diabetes Research (DZD), München-Neuherberg, Germany; Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany.
Prokesch A; Division of Cell Biology, Histology and Embryology, Gottfried Schatz Research Center for Cell Signaling, Metabolism & Aging, Medical University of Graz, Graz, Austria.
Schupp M; Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Institute of Pharmacology, Cardiovascular Metabolic Renal (CMR)-Research Center, Berlin, Germany. Electronic address: .
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Źródło:
The Journal of biological chemistry [J Biol Chem] 2022 Sep; Vol. 298 (9), pp. 102287. Date of Electronic Publication: 2022 Jul 20.
Typ publikacji:
Journal Article
MeSH Terms:
Forkhead Box Protein O1*/genetics
Forkhead Box Protein O1*/metabolism
Homeostasis*
Liver*/metabolism
Liver Glycogen*/metabolism
Tumor Suppressor Protein p53*/genetics
Tumor Suppressor Protein p53*/metabolism
Animals ; Gene Deletion ; Glucose/metabolism ; Hepatocytes/metabolism ; Insulin/metabolism ; Mice ; Triglycerides/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Cleavage of mitochondrial homeostasis regulator PGAM5 by the intramembrane protease PARL is governed by transmembrane helix dynamics and oligomeric state.
Autorzy:
Siebert V; Center for Molecular Biology of Heidelberg University (ZMBH), Heidelberg, Germany; Center for Biochemistry and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Medical Faculty, University of Cologne, Cologne, Germany.
Silber M; Institute for Biological Interfaces 4, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany.
Heuten E; Center for Molecular Biology of Heidelberg University (ZMBH), Heidelberg, Germany; Center for Biochemistry and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Medical Faculty, University of Cologne, Cologne, Germany.
Muhle-Goll C; Institute for Biological Interfaces 4, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany.
Lemberg MK; Center for Molecular Biology of Heidelberg University (ZMBH), Heidelberg, Germany; Center for Biochemistry and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Medical Faculty, University of Cologne, Cologne, Germany. Electronic address: .
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Źródło:
The Journal of biological chemistry [J Biol Chem] 2022 Sep; Vol. 298 (9), pp. 102321. Date of Electronic Publication: 2022 Jul 31.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Homeostasis*
Metalloproteases*/metabolism
Mitochondria*/enzymology
Mitochondrial Proteins*/metabolism
Phosphoprotein Phosphatases*/metabolism
Proteolysis*
HeLa Cells ; Humans ; Peptides/metabolism ; Protein Kinases/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
A general hypothesis of multistable systems in pathophysiology.
Autorzy:
Burlando B; Department of Pharmacy, University of Genoa, Genoa, 16132, Italy.
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Źródło:
F1000Research [F1000Res] 2022 Aug 05; Vol. 11, pp. 906. Date of Electronic Publication: 2022 Aug 05 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Homeostasis*
Humans
Czasopismo naukowe
Szczegóły
Tytuł:
Akkermansia muciniphila phospholipid induces homeostatic immune responses.
Autorzy:
Bae M; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Blavatnik Institute, Boston, MA, USA.; College of Pharmacy, Gachon University, Incheon, South Korea.
Cassilly CD; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Blavatnik Institute, Boston, MA, USA.
Liu X; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Blavatnik Institute, Boston, MA, USA.; Department of Cancer Biology and the Linde Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Park SM; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Tusi BK; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Chen X; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Kwon J; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Blavatnik Institute, Boston, MA, USA.; Natural Product Informatics Research Center, Korea Institute of Science and Technology (KIST), Ganeung, South Korea.
Filipčík P; Biochemistry Department, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.; SBGrid Consortium, Harvard Medical School, Blavatnik Institute, Boston, MA, USA.
Bolze AS; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Liu Z; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Vlamakis H; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Graham DB; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Buhrlage SJ; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Blavatnik Institute, Boston, MA, USA.; Department of Cancer Biology and the Linde Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Xavier RJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA. .; Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. .; Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. .
Clardy J; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Blavatnik Institute, Boston, MA, USA. jon_.
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Źródło:
Nature [Nature] 2022 Aug; Vol. 608 (7921), pp. 168-173. Date of Electronic Publication: 2022 Jul 27.
Typ publikacji:
Journal Article
MeSH Terms:
Akkermansia*/chemistry
Akkermansia*/cytology
Akkermansia*/immunology
Homeostasis*/immunology
Immunity*
Phosphatidylethanolamines*/chemical synthesis
Phosphatidylethanolamines*/chemistry
Phosphatidylethanolamines*/immunology
Cell Membrane/chemistry ; Cell Membrane/immunology ; Cytokines/immunology ; Humans ; Inflammation Mediators/chemical synthesis ; Inflammation Mediators/chemistry ; Inflammation Mediators/immunology ; Structure-Activity Relationship ; Toll-Like Receptor 1/immunology ; Toll-Like Receptor 2/agonists ; Toll-Like Receptor 2/immunology
SCR Organism:
Akkermansia muciniphila
Czasopismo naukowe
Szczegóły
Tytuł:
4-[1-Ethyl-1-methylhexy]-phenol induces apoptosis and interrupts Ca homeostasis via ROS pathway in Sertoli TM4 cells.
Autorzy:
Liu X; School of Chemical Engineering and Energy Technology, Dongguan University of Technology, Dongguan, 523808, China.; State Key Laboratory of Food Science and Technology, Nanchang University, 235 Nanjing East Road, Nanchang, 330047, China.; Engineering Research Center of Health Food Design & Nutrition Regulation, Institute of Science & Technology Innovation, Dongguan University of Technology, Dongguan, 523808, China.
Li F; Engineering Research Center of Health Food Design & Nutrition Regulation, Institute of Science & Technology Innovation, Dongguan University of Technology, Dongguan, 523808, China.
Zhu Z; Engineering Research Center of Health Food Design & Nutrition Regulation, Institute of Science & Technology Innovation, Dongguan University of Technology, Dongguan, 523808, China.
Peng G; School of Chemical Engineering and Energy Technology, Dongguan University of Technology, Dongguan, 523808, China.
Huang D; State Key Laboratory of Food Science and Technology, Nanchang University, 235 Nanjing East Road, Nanchang, 330047, China.
Xie M; State Key Laboratory of Food Science and Technology, Nanchang University, 235 Nanjing East Road, Nanchang, 330047, China. .
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Źródło:
Environmental science and pollution research international [Environ Sci Pollut Res Int] 2022 Jul; Vol. 29 (35), pp. 52665-52674. Date of Electronic Publication: 2022 Mar 10.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis*
Homeostasis*
Phenols*/pharmacology
Sertoli Cells*/cytology
Sertoli Cells*/drug effects
Acetylcysteine/pharmacology ; Adenosine Triphosphatases/metabolism ; Humans ; Male ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
New twists to the ALTernative endings at telomeres.
Autorzy:
Bhargava R; Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
Lynskey ML; Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
O'Sullivan RJ; Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: .
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Źródło:
DNA repair [DNA Repair (Amst)] 2022 Jul; Vol. 115, pp. 103342. Date of Electronic Publication: 2022 May 13.
Typ publikacji:
Journal Article; Review; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Telomerase*/metabolism
Telomere Homeostasis*
Chromatin ; Histones/genetics ; Telomere/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
The microbiome and gut homeostasis.
Autorzy:
Lee JY; Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, Davis, CA 95616, USA.
Tsolis RM; Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, Davis, CA 95616, USA.
Bäumler AJ; Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, Davis, CA 95616, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2022 Jul; Vol. 377 (6601), pp. eabp9960. Date of Electronic Publication: 2022 Jul 01.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Bacteria*/metabolism
Colon*/microbiology
Colon*/physiopathology
Dysbiosis*/microbiology
Dysbiosis*/physiopathology
Gastrointestinal Microbiome*
Homeostasis*
Intestine, Small*/microbiology
Intestine, Small*/physiopathology
Host Microbial Interactions ; Humans ; Nitrates/metabolism ; Oxygen/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Telomere dynamics in female Columbian ground squirrels: recovery after emergence and loss after reproduction.
Autorzy:
Viblanc VA; Université de Strasbourg, CNRS, IPHC UMR 7178, 67000, Strasbourg, France.
Criscuolo F; Université de Strasbourg, CNRS, IPHC UMR 7178, 67000, Strasbourg, France. .
Sosa S; Université de Strasbourg, CNRS, IPHC UMR 7178, 67000, Strasbourg, France.
Schull Q; MARBEC, University of Montpellier, IFREMER, IRD, CNRS, Avenue Jean Monnet CS 30171, 34203, Sète, France.
Boonstra R; Department of Biological Sciences, University of Toronto, Scarborough, ON, M1C 1A4, Canada.
Saraux C; Université de Strasbourg, CNRS, IPHC UMR 7178, 67000, Strasbourg, France.
Lejeune M; Université de Strasbourg, CNRS, IPHC UMR 7178, 67000, Strasbourg, France.
Roth JD; Department of Biological Sciences, Auburn University, Auburn, AL, USA.
Uhlrich P; Université de Strasbourg, CNRS, IPHC UMR 7178, 67000, Strasbourg, France.
Zahn S; Université de Strasbourg, CNRS, IPHC UMR 7178, 67000, Strasbourg, France.
Dobson FS; Université de Strasbourg, CNRS, IPHC UMR 7178, 67000, Strasbourg, France.; Department of Biological Sciences, Auburn University, Auburn, AL, USA.
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Źródło:
Oecologia [Oecologia] 2022 Jun; Vol. 199 (2), pp. 301-312. Date of Electronic Publication: 2022 Jun 17.
Typ publikacji:
Journal Article
MeSH Terms:
Telomere*
Telomere Homeostasis*
Animals ; Female ; Longitudinal Studies ; Male ; Reproduction/physiology ; Sciuridae/genetics
Czasopismo naukowe
Szczegóły
Tytuł:
Defusing ambiguities in the theory of homeostasis: novel concepts demand demarcation of "regulation" and "internal environment".
Autorzy:
Luca LA Jr; Department of Physiology & Pathology, School of Dentistry, São Paulo State University (UNESP), Araraquara, São Paulo, Brazil. Electronic address: .
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Źródło:
Physiology & behavior [Physiol Behav] 2022 May 15; Vol. 249, pp. 113752. Date of Electronic Publication: 2022 Feb 22.
Typ publikacji:
Letter; Comment
MeSH Terms:
Homeostasis*
Opinia redakcyjna
Szczegóły
Tytuł:
TIN2 deficiency leads to ALT-associated phenotypes and differentiation defects in embryonic stem cells.
Autorzy:
Yin S; MOE Key Laboratory of Gene Function and Regulation, Guangzhou Key Laboratory of Healthy Aging Research, SYSU-BCM Joint Research Center, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China; Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China.
Zhang F; MOE Key Laboratory of Gene Function and Regulation, Guangzhou Key Laboratory of Healthy Aging Research, SYSU-BCM Joint Research Center, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
Lin S; MOE Key Laboratory of Gene Function and Regulation, Guangzhou Key Laboratory of Healthy Aging Research, SYSU-BCM Joint Research Center, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
Chen W; MOE Key Laboratory of Gene Function and Regulation, Guangzhou Key Laboratory of Healthy Aging Research, SYSU-BCM Joint Research Center, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
Weng K; Shanghai Institute of Precision Medicine, Shanghai 200125, China.
Liu D; Verna and Marrs Mclean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Wang C; MOE Key Laboratory of Gene Function and Regulation, Guangzhou Key Laboratory of Healthy Aging Research, SYSU-BCM Joint Research Center, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
He Z; MOE Key Laboratory of Gene Function and Regulation, Guangzhou Key Laboratory of Healthy Aging Research, SYSU-BCM Joint Research Center, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
Chen Y; MOE Key Laboratory of Gene Function and Regulation, Guangzhou Key Laboratory of Healthy Aging Research, SYSU-BCM Joint Research Center, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
Ma W; MOE Key Laboratory of Gene Function and Regulation, Guangzhou Key Laboratory of Healthy Aging Research, SYSU-BCM Joint Research Center, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
Huang J; MOE Key Laboratory of Gene Function and Regulation, Guangzhou Key Laboratory of Healthy Aging Research, SYSU-BCM Joint Research Center, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
Huang Y; MOE Key Laboratory of Gene Function and Regulation, Guangzhou Key Laboratory of Healthy Aging Research, SYSU-BCM Joint Research Center, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China. Electronic address: .
Songyang Z; MOE Key Laboratory of Gene Function and Regulation, Guangzhou Key Laboratory of Healthy Aging Research, SYSU-BCM Joint Research Center, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China; Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China; Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou 510005, China. Electronic address: .
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Źródło:
Stem cell reports [Stem Cell Reports] 2022 May 10; Vol. 17 (5), pp. 1183-1197. Date of Electronic Publication: 2022 Apr 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Telomere*/genetics
Telomere Homeostasis*
Animals ; Embryonic Stem Cells/metabolism ; Mice ; Phenotype ; X-linked Nuclear Protein/genetics ; X-linked Nuclear Protein/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Emergence of multiple set-points of cellular homeostatic tension.
Autorzy:
Ueda Y; Division of Bioengineering, Graduate School of Engineering Science, Osaka University, Japan.
Deguchi S; Division of Bioengineering, Graduate School of Engineering Science, Osaka University, Japan. Electronic address: .
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Źródło:
Journal of biomechanics [J Biomech] 2023 Apr; Vol. 151, pp. 111543. Date of Electronic Publication: 2023 Mar 11.
Typ publikacji:
Journal Article
MeSH Terms:
Actins*/metabolism
Muscle Contraction*
Stress Fibers/ultrastructure ; Biophysics ; Homeostasis ; Stress, Mechanical
Czasopismo naukowe
Szczegóły
Wyświetlanie 1-20 z 179979

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