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Wyszukujesz frazę ""Homologous Recombination"" wg kryterium: Temat


Tytuł :
The dominant strain of SARS-CoV-2 is a mosaicism.
Autorzy :
Wang W; Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Science, Shandong Normal University, Jinan, Shandong 250014, China.
Li CP; Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Science, Shandong Normal University, Jinan, Shandong 250014, China.
He M; Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Science, Shandong Normal University, Jinan, Shandong 250014, China.
Li SW; Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Science, Shandong Normal University, Jinan, Shandong 250014, China.
Cao L; Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Science, Shandong Normal University, Jinan, Shandong 250014, China.
Ding NZ; Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Science, Shandong Normal University, Jinan, Shandong 250014, China.
He CQ; Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Science, Shandong Normal University, Jinan, Shandong 250014, China. Electronic address: .
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Źródło :
Virus research [Virus Res] 2021 Nov; Vol. 305, pp. 198553. Date of Electronic Publication: 2021 Sep 04.
Typ publikacji :
Historical Article; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Evolution, Molecular*
Genome, Viral*
Homologous Recombination*
Mosaicism*
COVID-19/*epidemiology
SARS-CoV-2/*genetics
Americas/epidemiology ; Asia/epidemiology ; Base Sequence ; COVID-19/history ; COVID-19/transmission ; COVID-19/virology ; Europe/epidemiology ; Genomics/methods ; History, 21st Century ; Humans ; Mutation ; Phylogeny ; SARS-CoV-2/classification ; SARS-CoV-2/pathogenicity
SCR Organism :
SARS-CoV-2 variants
Czasopismo naukowe
Tytuł :
POLθ-mediated end joining is restricted by RAD52 and BRCA2 until the onset of mitosis.
Autorzy :
Llorens-Agost M; Radiation Biology and DNA Repair, Technical University of Darmstadt, Darmstadt, Germany.
Ensminger M; Radiation Biology and DNA Repair, Technical University of Darmstadt, Darmstadt, Germany.
Le HP; Department of Microbiology and Molecular Genetics, University of California, Davis, Davis, CA, USA.
Gawai A; Radiation Biology and DNA Repair, Technical University of Darmstadt, Darmstadt, Germany.
Liu J; Department of Microbiology and Molecular Genetics, University of California, Davis, Davis, CA, USA.
Cruz-García A; Radiation Biology and DNA Repair, Technical University of Darmstadt, Darmstadt, Germany.
Bhetawal S; Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Smithville, TX, USA.
Wood RD; Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Smithville, TX, USA.
Heyer WD; Department of Microbiology and Molecular Genetics, University of California, Davis, Davis, CA, USA.
Löbrich M; Radiation Biology and DNA Repair, Technical University of Darmstadt, Darmstadt, Germany. .
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Źródło :
Nature cell biology [Nat Cell Biol] 2021 Oct; Vol. 23 (10), pp. 1095-1104. Date of Electronic Publication: 2021 Oct 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Breaks, Double-Stranded*
DNA End-Joining Repair*
Homologous Recombination*
Mitosis*
BRCA2 Protein/*metabolism
DNA-Directed DNA Polymerase/*metabolism
Rad52 DNA Repair and Recombination Protein/*metabolism
BRCA2 Protein/genetics ; Cell Cycle ; DNA-Directed DNA Polymerase/genetics ; HeLa Cells ; Humans ; Rad52 DNA Repair and Recombination Protein/genetics
Czasopismo naukowe
Tytuł :
Influences of ssDNA-RecA Filament Length on the Fidelity of Homologous Recombination.
Autorzy :
Danilowicz C; Department of Physics, Harvard University, Cambridge, MA 02138, USA.
Vietorisz E; Department of Physics, Harvard University, Cambridge, MA 02138, USA.
Godoy-Carter V; Department of Biology, Northeastern University, Boston, MA 02115, USA.
Prévost C; Laboratoire de Biochimie Théorique, CNRS Université de Paris, UPR 9080, 13 rue Pierre et Marie Curie, F-75005 Paris, France; Institut de Biologie Physico-Chimique, Fondation Edmond de Rotschild, PSL Research University, Paris, France.
Prentiss M; Department of Physics, Harvard University, Cambridge, MA 02138, USA.
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Źródło :
Journal of molecular biology [J Mol Biol] 2021 Sep 03; Vol. 433 (18), pp. 167143. Date of Electronic Publication: 2021 Jul 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Repair*
DNA Replication*
Homologous Recombination*
DNA/*genetics
DNA, Single-Stranded/*genetics
Rec A Recombinases/*metabolism
Adenosine Triphosphate/metabolism ; DNA/chemistry ; DNA, Single-Stranded/chemistry ; Models, Molecular ; Rec A Recombinases/genetics
Czasopismo naukowe
Tytuł :
Recombination in a sterile polyploid hybrid yeast upon meiotic Return-To-Growth.
Autorzy :
Serero A; Institut Curie, Centre de Recherche, CNRS UMR3244, PSL Research University, 26 rue d'Ulm, 75248, Paris, Cedex 05, France; Meiogenix, 38 rue Servan, 75544, Paris, Cedex 11, France.
Bedrat A; Institut Curie, Centre de Recherche, CNRS UMR3244, PSL Research University, 26 rue d'Ulm, 75248, Paris, Cedex 05, France; Meiogenix, 38 rue Servan, 75544, Paris, Cedex 11, France.
Baulande S; ICGEX NGS Platform, Institut Curie, 26 rue d'Ulm, 75248, Paris, Cedex 05, France.
Bastianelli G; Meiogenix, 38 rue Servan, 75544, Paris, Cedex 11, France.
Colavizza D; Lesaffre international, Direction R&D, Service Génétique, 147 rue Gabriel Péri, 59700, Marcq-en-Barœul, France.
Desfougères T; Lesaffre international, Direction R&D, Service Génétique, 147 rue Gabriel Péri, 59700, Marcq-en-Barœul, France.
Pignède G; Lesaffre international, Direction R&D, Service Génétique, 147 rue Gabriel Péri, 59700, Marcq-en-Barœul, France.
Quipourt-Isnard AD; Lesaffre international, Direction R&D, Service Génétique, 147 rue Gabriel Péri, 59700, Marcq-en-Barœul, France.
Nicolas A; Institut Curie, Centre de Recherche, CNRS UMR3244, PSL Research University, 26 rue d'Ulm, 75248, Paris, Cedex 05, France; Meiogenix, 38 rue Servan, 75544, Paris, Cedex 11, France. Electronic address: .
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Źródło :
Microbiological research [Microbiol Res] 2021 Sep; Vol. 250, pp. 126789. Date of Electronic Publication: 2021 May 21.
Typ publikacji :
Journal Article
MeSH Terms :
Homologous Recombination*
Meiosis/*genetics
Saccharomyces cerevisiae/*genetics
Saccharomyces cerevisiae/*growth & development
Genome, Fungal ; Phenotype ; Polyploidy
Czasopismo naukowe
Tytuł :
Chromosomal Location Determines the Rate of Intrachromosomal Homologous Recombination in Salmonella.
Autorzy :
Garmendia E; Department of Medical Biochemistry and Microbiology, Biomedical Center, Uppsala University, Uppsala, Sweden.
Brandis G; Department of Medical Biochemistry and Microbiology, Biomedical Center, Uppsala University, Uppsala, Sweden.
Guy L; Department of Medical Biochemistry and Microbiology, Biomedical Center, Uppsala University, Uppsala, Sweden.
Cao S; Department of Medical Biochemistry and Microbiology, Biomedical Center, Uppsala University, Uppsala, Sweden.
Hughes D; Department of Medical Biochemistry and Microbiology, Biomedical Center, Uppsala University, Uppsala, Sweden.
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Źródło :
MBio [mBio] 2021 Jun 29; Vol. 12 (3), pp. e0115121. Date of Electronic Publication: 2021 Jun 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Homologous Recombination*
Chromosomes, Bacterial/*genetics
Salmonella/*genetics
DNA Repair
Czasopismo naukowe
Tytuł :
Rad52 Oligomeric N-Terminal Domain Stabilizes Rad51 Nucleoprotein Filaments and Contributes to Their Protection against Srs2.
Autorzy :
Ma E; Université de Paris and Université Paris-Saclay, Inserm, LGRM/iRCM/IBFJ-CEA, UMR Stabilité Génétique Cellules Souches et Radiations, F-92265 Fontenay-Aux-Roses, France.
Maloisel L; Université de Paris and Université Paris-Saclay, Inserm, LGRM/iRCM/IBFJ-CEA, UMR Stabilité Génétique Cellules Souches et Radiations, F-92265 Fontenay-Aux-Roses, France.
Le Falher L; Present address: Precision Oncology Genomics, Oncology Therapeutic Area, Sanofi R&D, F-94403 Vitry-Sur-Seine, France.
Guérois R; Université Paris Saclay, CNRS, LBSR/i2BC-CEA, Institute for Integrative Biology of the Cell (I2BC), F-91198 Gif-Sur-Yvette, France.
Coïc E; Université de Paris and Université Paris-Saclay, Inserm, LGRM/iRCM/IBFJ-CEA, UMR Stabilité Génétique Cellules Souches et Radiations, F-92265 Fontenay-Aux-Roses, France.
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Źródło :
Cells [Cells] 2021 Jun 11; Vol. 10 (6). Date of Electronic Publication: 2021 Jun 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Homologous Recombination*
Mutation*
DNA Helicases/*metabolism
Rad51 Recombinase/*chemistry
Rad52 DNA Repair and Recombination Protein/*metabolism
Saccharomyces cerevisiae/*metabolism
Saccharomyces cerevisiae Proteins/*chemistry
Saccharomyces cerevisiae Proteins/*metabolism
DNA Helicases/genetics ; Protein Domains ; Rad51 Recombinase/genetics ; Rad51 Recombinase/metabolism ; Rad52 DNA Repair and Recombination Protein/chemistry ; Rad52 DNA Repair and Recombination Protein/genetics ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae Proteins/genetics
Czasopismo naukowe
Tytuł :
Altered replication stress response due to CARD14 mutations promotes recombination-induced revertant mosaicism.
Autorzy :
Miyauchi T; Department of Dermatology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido 060-8638, Japan.
Suzuki S; Department of Dermatology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido 060-8638, Japan.
Takeda M; Department of Dermatology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido 060-8638, Japan.
Peh JT; Department of Dermatology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido 060-8638, Japan.
Aiba M; Department of Dermatology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido 060-8638, Japan.
Natsuga K; Department of Dermatology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido 060-8638, Japan.
Fujita Y; Department of Dermatology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido 060-8638, Japan.
Takeichi T; Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, 466-8550, Japan.
Sakamoto T; Sakamoto Clinic, Fujieda, Shizuoka 426-0063, Japan.
Akiyama M; Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, 466-8550, Japan.
Shimizu H; Department of Dermatology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido 060-8638, Japan.
Nomura T; Department of Dermatology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido 060-8638, Japan; Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan. Electronic address: .
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Źródło :
American journal of human genetics [Am J Hum Genet] 2021 Jun 03; Vol. 108 (6), pp. 1026-1039. Date of Electronic Publication: 2021 May 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Replication*
Homologous Recombination*
Mosaicism*
Mutation*
Stress, Physiological*
CARD Signaling Adaptor Proteins/*genetics
Guanylate Cyclase/*genetics
Membrane Proteins/*genetics
Pityriasis Rubra Pilaris/*pathology
Psoriasis/*pathology
Cell Cycle ; Humans ; Pityriasis Rubra Pilaris/genetics ; Psoriasis/genetics
Czasopismo naukowe
Tytuł :
BARD1 reads H2A lysine 15 ubiquitination to direct homologous recombination.
Autorzy :
Becker JR; Medical Research Council (MRC) Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Clifford G; Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh, UK.
Bonnet C; Medical Research Council (MRC) Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Groth A; The Novo Nordisk Center for Protein Research (CPR), Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.; Biotech Research and Innovation Centre (BRIC), Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
Wilson MD; Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh, UK.
Chapman JR; Medical Research Council (MRC) Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK. .; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK. .; NIHR Biomedical Research Centre, University of Oxford, Oxford, UK. .
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Źródło :
Nature [Nature] 2021 Aug; Vol. 596 (7872), pp. 433-437. Date of Electronic Publication: 2021 Jul 28.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Homologous Recombination*
Ubiquitination*
Lysine/*chemistry
Lysine/*metabolism
Tumor Suppressor Proteins/*metabolism
Ubiquitin-Protein Ligases/*metabolism
Adult ; Amino Acid Motifs ; BRCA1 Protein/chemistry ; BRCA1 Protein/metabolism ; Chromatin/metabolism ; Cisplatin/pharmacology ; DNA Breaks, Double-Stranded ; DNA Damage/drug effects ; Female ; HCT116 Cells ; HEK293 Cells ; Histones/chemistry ; Histones/metabolism ; Humans ; Male ; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology ; Protein Domains ; Recombinational DNA Repair ; Tumor Suppressor Proteins/chemistry ; Tumor Suppressor p53-Binding Protein 1/deficiency ; Tumor Suppressor p53-Binding Protein 1/metabolism ; Ubiquitin/metabolism ; Ubiquitin-Protein Ligases/chemistry ; Ubiquitin-Protein Ligases/deficiency
Czasopismo naukowe
Tytuł :
Recombination machinery engineering facilitates metabolic engineering of the industrial yeast Pichia pastoris.
Autorzy :
Cai P; Division of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.; School of Bioengineering, Dalian University of Technology, Dalian 116024, China.
Duan X; Division of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.; Dalian Key Laboratory of Energy Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
Wu X; Division of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.; Dalian Key Laboratory of Energy Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Gao L; Division of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.; Dalian Key Laboratory of Energy Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Ye M; Division of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.; Dalian Key Laboratory of Energy Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Zhou YJ; Division of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.; CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.; Dalian Key Laboratory of Energy Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.; Laboratory of Synthetic Biology for Biocataysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Jul 21; Vol. 49 (13), pp. 7791-7805.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Homologous Recombination*
Metabolic Engineering*
Saccharomycetales/*genetics
CRISPR-Cas Systems ; Fatty Alcohols/metabolism ; Gene Editing ; Gene Expression ; Metabolic Networks and Pathways/genetics ; Promoter Regions, Genetic ; Saccharomycetales/metabolism
SCR Organism :
Komagataella pastoris
Czasopismo naukowe
Tytuł :
NuA4 and SAGA acetyltransferase complexes cooperate for repair of DNA breaks by homologous recombination.
Autorzy :
Cheng X; St-Patrick Research Group in Basic Oncology, Laval University Cancer Research Center, Oncology Division of CHU de Québec-Université Laval Research Center, Quebec City, Canada.
Côté V; St-Patrick Research Group in Basic Oncology, Laval University Cancer Research Center, Oncology Division of CHU de Québec-Université Laval Research Center, Quebec City, Canada.
Côté J; St-Patrick Research Group in Basic Oncology, Laval University Cancer Research Center, Oncology Division of CHU de Québec-Université Laval Research Center, Quebec City, Canada.
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Źródło :
PLoS genetics [PLoS Genet] 2021 Jul 06; Vol. 17 (7), pp. e1009459. Date of Electronic Publication: 2021 Jul 06 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Homologous Recombination*
DNA Repair/*physiology
Histone Acetyltransferases/*genetics
Saccharomyces cerevisiae/*genetics
Saccharomyces cerevisiae Proteins/*genetics
Trans-Activators/*genetics
Acetylation ; Chromatin/genetics ; Chromatin/metabolism ; DNA Breaks, Double-Stranded ; Histone Acetyltransferases/metabolism ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/metabolism ; Trans-Activators/metabolism
Czasopismo naukowe
Tytuł :
DHX9-dependent recruitment of BRCA1 to RNA promotes DNA end resection in homologous recombination.
Autorzy :
Chakraborty P; Division of Cellular Medicine, Jacqui Wood Cancer Centre, School of Medicine, University of Dundee, Scotland, United Kingdom.
Hiom K; Division of Cellular Medicine, Jacqui Wood Cancer Centre, School of Medicine, University of Dundee, Scotland, United Kingdom. .
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Źródło :
Nature communications [Nat Commun] 2021 Jul 05; Vol. 12 (1), pp. 4126. Date of Electronic Publication: 2021 Jul 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA*
Homologous Recombination*
RNA*
BRCA1 Protein/*metabolism
DEAD-box RNA Helicases/*metabolism
Neoplasm Proteins/*metabolism
BRCA1 Protein/genetics ; DEAD-box RNA Helicases/genetics ; DNA Damage ; DNA Helicases ; DNA Repair ; DNA Replication ; DNA-Binding Proteins/metabolism ; Humans ; Phthalazines ; Piperazines ; RNA Helicases ; RNA, Messenger ; Rad51 Recombinase ; Recombinational DNA Repair
Czasopismo naukowe
Tytuł :
Localization matters: nuclear-trapped Survivin sensitizes glioblastoma cells to temozolomide by elevating cellular senescence and impairing homologous recombination.
Autorzy :
Reich TR; Department of Toxicology, University Medical Center, Mainz, Germany.
Schwarzenbach C; Department of Toxicology, University Medical Center, Mainz, Germany.
Vilar JB; Department of Toxicology, University Medical Center, Mainz, Germany.
Unger S; Department of Toxicology, University Medical Center, Mainz, Germany.
Mühlhäusler F; Department of Toxicology, University Medical Center, Mainz, Germany.
Nikolova T; Department of Toxicology, University Medical Center, Mainz, Germany.
Poplawski A; Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center, Mainz, Germany.
Baymaz HI; Institute of Molecular Biology (IMB), Johannes Gutenberg University, Mainz, Germany.
Beli P; Institute of Molecular Biology (IMB), Johannes Gutenberg University, Mainz, Germany.
Christmann M; Department of Toxicology, University Medical Center, Mainz, Germany.
Tomicic MT; Department of Toxicology, University Medical Center, Mainz, Germany. .
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Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2021 Jul; Vol. 78 (14), pp. 5587-5604. Date of Electronic Publication: 2021 Jun 08.
Typ publikacji :
Journal Article
MeSH Terms :
Cellular Senescence*
Drug Resistance, Neoplasm*
Homologous Recombination*
Cell Nucleus/*metabolism
Glioblastoma/*drug therapy
Survivin/*metabolism
Temozolomide/*pharmacology
Animals ; Antineoplastic Agents, Alkylating/pharmacology ; Apoptosis ; Biomarkers, Tumor ; Brain Neoplasms/drug therapy ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Cell Nucleus/genetics ; Cell Proliferation ; DNA Damage ; DNA Repair ; Female ; Gene Expression Regulation, Neoplastic ; Glioblastoma/metabolism ; Glioblastoma/pathology ; Humans ; Mice ; Mice, Nude ; Survivin/genetics ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Homology-Based Interactions between Small RNAs and Their Targets Control Dominance Hierarchy of Male Determinant Alleles of Self-Incompatibility in Arabidopsis lyrata .
Autorzy :
Yasuda S; Division of Biological Sciences, Nara Institute of Science and Technology, Nara 630-0192, Japan.
Kobayashi R; Division of Biological Sciences, Nara Institute of Science and Technology, Nara 630-0192, Japan.
Ito T; Division of Biological Sciences, Nara Institute of Science and Technology, Nara 630-0192, Japan.
Wada Y; Division of Biological Sciences, Nara Institute of Science and Technology, Nara 630-0192, Japan.
Takayama S; Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 29; Vol. 22 (13). Date of Electronic Publication: 2021 Jun 29.
Typ publikacji :
Journal Article
MeSH Terms :
Epistasis, Genetic*
Gene Expression Regulation, Plant*
Genes, Dominant*
Homologous Recombination*
RNA, Plant*
Social Dominance*
Arabidopsis/*genetics
Alleles ; Genotype ; Haplotypes ; Nucleic Acid Conformation
Czasopismo naukowe
Tytuł :
Eliminating hypoxic tumor cells improves response to PARP inhibitors in homologous recombination-deficient cancer models.
Autorzy :
Mehibel M; Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University Medical Center, Stanford, California, USA.
Xu Y; Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University Medical Center, Stanford, California, USA.
Li CG; Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University Medical Center, Stanford, California, USA.
Moon EJ; Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University Medical Center, Stanford, California, USA.
Thakkar KN; Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University Medical Center, Stanford, California, USA.
Diep AN; Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University Medical Center, Stanford, California, USA.
Kim RK; Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University Medical Center, Stanford, California, USA.
Bloomstein JD; Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University Medical Center, Stanford, California, USA.
Xiao Y; Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University Medical Center, Stanford, California, USA.
Bacal J; Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California, USA.
Saldivar JC; Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California, USA.
Le QT; Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University Medical Center, Stanford, California, USA.
Cimprich KA; Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California, USA.
Rankin EB; Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University Medical Center, Stanford, California, USA.; Department of Obstetrics and Gynecology, Stanford University Medical Center, Stanford, California, USA.
Giaccia AJ; Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University Medical Center, Stanford, California, USA.; Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom.
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Źródło :
The Journal of clinical investigation [J Clin Invest] 2021 Jun 01; Vol. 131 (11).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Damage*
Homologous Recombination*
Neoplasms, Experimental*/drug therapy
Neoplasms, Experimental*/genetics
Neoplasms, Experimental*/metabolism
Poly(ADP-ribose) Polymerase Inhibitors/*pharmacology
Reactive Oxygen Species/*metabolism
Animals ; Cell Hypoxia/drug effects ; Cell Hypoxia/genetics ; Cell Line, Tumor ; Female ; Humans ; Mice ; Mice, Nude ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Pold4, the fourth subunit of replicative polymerase δ, suppresses gene conversion in the immunoglobulin-variable gene in avian DT40 cells.
Autorzy :
Kojima K; Department of Chemistry, Graduate School of Science, Tokyo Metropolitan University, Minamiosawa 1-1, Hachioji-shi, Tokyo, 192-0397, Japan.
Ooka M; Department of Chemistry, Graduate School of Science, Tokyo Metropolitan University, Minamiosawa 1-1, Hachioji-shi, Tokyo, 192-0397, Japan.
Abe T; Department of Chemistry, Graduate School of Science, Tokyo Metropolitan University, Minamiosawa 1-1, Hachioji-shi, Tokyo, 192-0397, Japan.
Hirota K; Department of Chemistry, Graduate School of Science, Tokyo Metropolitan University, Minamiosawa 1-1, Hachioji-shi, Tokyo, 192-0397, Japan. Electronic address: .
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Źródło :
DNA repair [DNA Repair (Amst)] 2021 Apr; Vol. 100, pp. 103056. Date of Electronic Publication: 2021 Feb 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
DNA Damage*
Gene Conversion*
Homologous Recombination*
Chickens/*metabolism
Immunoglobulin Variable Region/*metabolism
Animals ; Cell Line ; Chickens/genetics ; DNA/metabolism ; DNA Breaks, Double-Stranded ; DNA Repair ; DNA Replication ; Immunoglobulin Variable Region/genetics
Czasopismo naukowe
Tytuł :
Super-resolution mapping of cellular double-strand break resection complexes during homologous recombination.
Autorzy :
Whelan DR; Department of Pharmacy and Biomedical Sciences, La Trobe Institute for Molecular Science, La Trobe University, Bendigo, VIC 3552, Australia; .
Rothenberg E; Department of Biochemistry and Molecular Pharmacology, Perlmutter Cancer Center, New York University School of Medicine, New York, NY 10016 .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Mar 16; Vol. 118 (11).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Breaks, Double-Stranded*
Homologous Recombination*
Recombinational DNA Repair*
Single Molecule Imaging*
BRCA1 Protein/metabolism ; Cell Line, Tumor ; DNA Helicases/metabolism ; DNA Repair Enzymes/metabolism ; DNA, Single-Stranded/metabolism ; Endodeoxyribonucleases/metabolism ; Exodeoxyribonucleases/metabolism ; Humans ; MRE11 Homologue Protein/metabolism ; Multiprotein Complexes/metabolism ; RecQ Helicases/metabolism ; Tumor Suppressor p53-Binding Protein 1/metabolism
Czasopismo naukowe
Tytuł :
The Rad51 paralog complex Rad55-Rad57 acts as a molecular chaperone during homologous recombination.
Autorzy :
Roy U; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.
Kwon Y; Department of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Marie L; Department of Microbiology and Immunology, Columbia University, New York, NY 10032, USA.
Symington L; Department of Microbiology and Immunology, Columbia University, New York, NY 10032, USA.
Sung P; Department of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Lisby M; Department of Biology, University of Copenhagen, 2200 Copenhagen N, Denmark; Center for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen N, Denmark.
Greene EC; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2021 Mar 04; Vol. 81 (5), pp. 1043-1057.e8. Date of Electronic Publication: 2021 Jan 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Gene Expression Regulation, Fungal*
Homologous Recombination*
Adenosine Triphosphatases/*genetics
DNA Helicases/*genetics
DNA Repair Enzymes/*genetics
DNA-Binding Proteins/*genetics
Rad51 Recombinase/*genetics
Saccharomyces cerevisiae/*genetics
Saccharomyces cerevisiae Proteins/*genetics
Adenosine Triphosphatases/metabolism ; Binding Sites ; DNA Helicases/metabolism ; DNA Repair Enzymes/metabolism ; DNA, Fungal/genetics ; DNA, Fungal/metabolism ; DNA, Single-Stranded/genetics ; DNA, Single-Stranded/metabolism ; DNA-Binding Proteins/metabolism ; Genes, Reporter ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; Luminescent Proteins/genetics ; Luminescent Proteins/metabolism ; Molecular Chaperones/genetics ; Molecular Chaperones/metabolism ; Mutation ; Protein Binding ; Rad51 Recombinase/metabolism ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/metabolism ; Signal Transduction ; Single Molecule Imaging
Czasopismo naukowe
Tytuł :
Evaluating the Genomic Parameters Governing rAAV-Mediated Homologous Recombination.
Autorzy :
Spector LP; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Tiffany M; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
Ferraro NM; Biomedical Informatics Program, Stanford University School of Medicine, Stanford, CA, USA.
Abell NS; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Montgomery SB; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Kay MA; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: .
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Źródło :
Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2021 Mar 03; Vol. 29 (3), pp. 1028-1046. Date of Electronic Publication: 2020 Nov 26.
Typ publikacji :
Evaluation Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Homologous Recombination*
Transgenes*
Chromatin/*genetics
Dependovirus/*genetics
Gene Targeting/*methods
Gene Transfer Techniques/*statistics & numerical data
Genetic Vectors/*genetics
Genetic Vectors/administration & dosage ; Humans ; K562 Cells
Czasopismo naukowe
Tytuł :
Pathogenicity assessment of variants for breast cancer susceptibility genes based on BRCAness of tumor sample.
Autorzy :
Yoshida R; Department of Oncotherapeutic Medicine, Graduate School of Medicine, Tohoku University, Sendai, Japan.; Division of Cancer Genomics, Cancer Institute, Japanese Foundation for Cancer Research (JFCR), Tokyo, Japan.; Department of Clinical Genetic Oncology, Cancer Institute Hospital (CIH), JFCR, Tokyo, Japan.
Hagio T; Division of Cancer Genomics, Cancer Institute, Japanese Foundation for Cancer Research (JFCR), Tokyo, Japan.; Project for Development of Innovative Research on Cancer Therapeutics, Cancer Precision Medicine Center, JFCR, Tokyo, Japan.
Kaneyasu T; Division of Cancer Genomics, Cancer Institute, Japanese Foundation for Cancer Research (JFCR), Tokyo, Japan.; Project for Development of Innovative Research on Cancer Therapeutics, Cancer Precision Medicine Center, JFCR, Tokyo, Japan.
Gotoh O; Division of Cancer Genomics, Cancer Institute, Japanese Foundation for Cancer Research (JFCR), Tokyo, Japan.; Project for Development of Innovative Research on Cancer Therapeutics, Cancer Precision Medicine Center, JFCR, Tokyo, Japan.
Osako T; Division of Pathology, Cancer Institute, JFCR, Tokyo, Japan.
Tanaka N; Division of Cancer Genomics, Cancer Institute, Japanese Foundation for Cancer Research (JFCR), Tokyo, Japan.; Project for Development of Innovative Research on Cancer Therapeutics, Cancer Precision Medicine Center, JFCR, Tokyo, Japan.
Amino S; Division of Cancer Genomics, Cancer Institute, Japanese Foundation for Cancer Research (JFCR), Tokyo, Japan.; Project for Development of Genomics-based Cancer Medicine, Cancer Precision Medicine Center, JFCR, Tokyo, Japan.
Yaguchi N; Division of Cancer Genomics, Cancer Institute, Japanese Foundation for Cancer Research (JFCR), Tokyo, Japan.; Project for Development of Innovative Research on Cancer Therapeutics, Cancer Precision Medicine Center, JFCR, Tokyo, Japan.
Nakashima E; Breast Oncology Center, CIH, JFCR, Tokyo, Japan.
Kitagawa D; Breast Oncology Center, CIH, JFCR, Tokyo, Japan.; Department of Breast Surgical Oncology, Center Hospital of the National Center for Global Health and Medicine, Tokyo, Japan.
Ueno T; Breast Oncology Center, CIH, JFCR, Tokyo, Japan.
Ohno S; Breast Oncology Center, CIH, JFCR, Tokyo, Japan.
Nakajima T; Department of Clinical Genetic Oncology, Cancer Institute Hospital (CIH), JFCR, Tokyo, Japan.
Nakamura S; Division of Breast Surgical Oncology, Showa University School of Medicine, Tokyo, Japan.
Miki Y; Division of Genetic Diagnosis, Cancer Institute, JFCR, Tokyo, Japan.
Hirota T; Department of Cellular and Molecular Imaging of Cancer, Graduate School of Medicine, Tohoku University, Sendai, Japan.; Division of Experimental Pathology, Cancer Institute, JFCR, Tokyo, Japan.
Takahashi S; Department of Oncotherapeutic Medicine, Graduate School of Medicine, Tohoku University, Sendai, Japan.; Department of Medical Oncology, CIH, JFCR, Tokyo, Japan.
Matsuura M; Division of Cancer Genomics, Cancer Institute, Japanese Foundation for Cancer Research (JFCR), Tokyo, Japan.
Noda T; Division of Cancer Genomics, Cancer Institute, Japanese Foundation for Cancer Research (JFCR), Tokyo, Japan.; Project for Development of Genomics-based Cancer Medicine, Cancer Precision Medicine Center, JFCR, Tokyo, Japan.; Cancer, Institute, JFCR, Tokyo, Japan.
Mori S; Division of Cancer Genomics, Cancer Institute, Japanese Foundation for Cancer Research (JFCR), Tokyo, Japan.; Project for Development of Innovative Research on Cancer Therapeutics, Cancer Precision Medicine Center, JFCR, Tokyo, Japan.
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Źródło :
Cancer science [Cancer Sci] 2021 Mar; Vol. 112 (3), pp. 1310-1319. Date of Electronic Publication: 2021 Feb 02.
Typ publikacji :
Journal Article; Observational Study; Validation Study
MeSH Terms :
Genetic Predisposition to Disease*
Homologous Recombination*
Models, Genetic*
Biomarkers, Tumor/*genetics
Breast Neoplasms/*genetics
Adult ; Aged ; Ataxia Telangiectasia Mutated Proteins/genetics ; BRCA1 Protein/genetics ; BRCA2 Protein/genetics ; Breast/pathology ; Breast/surgery ; Breast Neoplasms/pathology ; Breast Neoplasms/surgery ; Checkpoint Kinase 2/genetics ; DNA Mutational Analysis ; Datasets as Topic ; Exome/genetics ; Fanconi Anemia Complementation Group N Protein/genetics ; Female ; Genetic Testing/methods ; Germ-Line Mutation ; Humans ; Mastectomy ; Middle Aged ; Whole Exome Sequencing
Czasopismo naukowe
Tytuł :
CXCL10 potentiates immune checkpoint blockade therapy in homologous recombination-deficient tumors.
Autorzy :
Shi Z; Obstetrics and Gynecology Hospital, NHC Key Laboratory of Reproduction Regualtion, Shanghai Institute of Planned Parenthood Research, State Key Laboratory of Genetic Engineering at School of Life Sciences, Institute of Reproduction and Development, Fudan University, Shanghai 200032, China.; Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Institute of Metabolism and Integrative Biology, Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, China.
Shen J; Department of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 200025, China.; Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, 200025, China.
Qiu J; Obstetrics and Gynecology Hospital, NHC Key Laboratory of Reproduction Regualtion, Shanghai Institute of Planned Parenthood Research, State Key Laboratory of Genetic Engineering at School of Life Sciences, Institute of Reproduction and Development, Fudan University, Shanghai 200032, China.; Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Institute of Metabolism and Integrative Biology, Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, China.
Zhao Q; Obstetrics and Gynecology Hospital, NHC Key Laboratory of Reproduction Regualtion, Shanghai Institute of Planned Parenthood Research, State Key Laboratory of Genetic Engineering at School of Life Sciences, Institute of Reproduction and Development, Fudan University, Shanghai 200032, China.
Hua K; Obstetrics and Gynecology Hospital, NHC Key Laboratory of Reproduction Regualtion, Shanghai Institute of Planned Parenthood Research, State Key Laboratory of Genetic Engineering at School of Life Sciences, Institute of Reproduction and Development, Fudan University, Shanghai 200032, China.; Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Institute of Metabolism and Integrative Biology, Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, China.
Wang H; Obstetrics and Gynecology Hospital, NHC Key Laboratory of Reproduction Regualtion, Shanghai Institute of Planned Parenthood Research, State Key Laboratory of Genetic Engineering at School of Life Sciences, Institute of Reproduction and Development, Fudan University, Shanghai 200032, China.; Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Institute of Metabolism and Integrative Biology, Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, China.; Children's Hospital of Fudan University, Shanghai 201100, China.
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Źródło :
Theranostics [Theranostics] 2021 May 24; Vol. 11 (15), pp. 7175-7187. Date of Electronic Publication: 2021 May 24 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Breast Neoplasms*/genetics
Breast Neoplasms*/immunology
Breast Neoplasms*/therapy
Chemokine CXCL10*/genetics
Chemokine CXCL10*/immunology
Databases, Nucleic Acid*
Homologous Recombination*
Polymorphism, Single Nucleotide*
Genomic Instability/*immunology
Immune Checkpoint Inhibitors/*therapeutic use
Neoplasm Proteins/*immunology
Female ; Humans ; Immunotherapy ; Neoplasm Proteins/genetics ; Tumor Microenvironment/drug effects ; Tumor Microenvironment/genetics ; Tumor Microenvironment/immunology
Czasopismo naukowe

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