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Tytuł :
Double Prenylation of SNARE Protein Ykt6 Is Required for Lysosomal Hydrolase Trafficking.
Autorzy :
Sakata N; Department of Molecular and Cellular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Shirakawa R; Department of Molecular and Cellular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Goto K; Department of Molecular and Cellular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Trinh DA; Department of Molecular and Cellular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Horiuchi H; Department of Molecular and Cellular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
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Źródło :
Journal of biochemistry [J Biochem] 2020 Oct 09. Date of Electronic Publication: 2020 Oct 09.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Detection of acquired von Willebrand syndrome after ventricular assist device by total thrombus-formation analysis system.
Autorzy :
Takashio S; Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Center for Metabolic Regulation of Healthy Aging, Kumamoto University, Kumamoto, Japan.
Kaikita K; Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Center for Metabolic Regulation of Healthy Aging, Kumamoto University, Kumamoto, Japan.
Nishi M; Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Center for Metabolic Regulation of Healthy Aging, Kumamoto University, Kumamoto, Japan.
Morioka M; Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Center for Metabolic Regulation of Healthy Aging, Kumamoto University, Kumamoto, Japan.
Higo T; Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Shiose A; Department of Cardiovascular Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Doman T; Department of Molecular and Cellular Biology, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan.
Horiuchi H; Department of Molecular and Cellular Biology, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan.
Fukui T; Department of Cardiovascular Surgery, Graduate School of Medical Sciences, Center for Metabolic Regulation of Healthy Aging, Kumamoto University, Kumamoto, Japan.
Tsujita K; Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Center for Metabolic Regulation of Healthy Aging, Kumamoto University, Kumamoto, Japan.
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Źródło :
ESC heart failure [ESC Heart Fail] 2020 Oct; Vol. 7 (5), pp. 3235-3239. Date of Electronic Publication: 2020 Jul 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Czasopismo naukowe
Tytuł :
A SNARE geranylgeranyltransferase essential for the organization of the Golgi apparatus.
Autorzy :
Shirakawa R; Department of Molecular and Cellular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Goto-Ito S; Institute for Quantitative Biosciences, The University of Tokyo, Tokyo, Japan.; Synchrotron Radiation Research Organization, The University of Tokyo, Tokyo, Japan.
Goto K; Department of Molecular and Cellular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Wakayama S; Department of Molecular and Cellular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Kubo H; Department of Molecular and Cellular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Sakata N; Department of Molecular and Cellular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Trinh DA; Department of Molecular and Cellular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Yamagata A; Institute for Quantitative Biosciences, The University of Tokyo, Tokyo, Japan.; Synchrotron Radiation Research Organization, The University of Tokyo, Tokyo, Japan.
Sato Y; Institute for Quantitative Biosciences, The University of Tokyo, Tokyo, Japan.; Synchrotron Radiation Research Organization, The University of Tokyo, Tokyo, Japan.
Masumoto H; Biomedical Research Support Center, Nagasaki University School of Medicine, Nagasaki, Japan.
Cheng J; Department of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Fujimoto T; Research Institute for Diseases of Old Age, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Fukai S; Institute for Quantitative Biosciences, The University of Tokyo, Tokyo, Japan.; Synchrotron Radiation Research Organization, The University of Tokyo, Tokyo, Japan.
Horiuchi H; Department of Molecular and Cellular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
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Źródło :
The EMBO journal [EMBO J] 2020 Apr 15; Vol. 39 (8), pp. e104120. Date of Electronic Publication: 2020 Mar 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alkyl and Aryl Transferases/*metabolism
Dimethylallyltranstransferase/*metabolism
R-SNARE Proteins/*metabolism
SNARE Proteins/*metabolism
Alkyl and Aryl Transferases/chemistry ; Alkyl and Aryl Transferases/genetics ; Animals ; Dimethylallyltranstransferase/chemistry ; Dimethylallyltranstransferase/genetics ; Golgi Apparatus/metabolism ; Humans ; Male ; Membrane Fusion ; Protein Binding ; Protein Multimerization ; Protein Prenylation ; Protein Transport ; R-SNARE Proteins/genetics ; Rats ; Rats, Wistar
Czasopismo naukowe
Tytuł :
Disappearance of Angiodysplasia Following Transcatheter Aortic Valve Implantation in a Patient with Heyde's Syndrome: A Case Report and Review of the Literature.
Autorzy :
Tsuchiya S; Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine.
Matsumoto Y; Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine.
Doman T; Department of Molecular and Cellular Biology, Institute of Development, Aging, and Cancer, Tohoku University.
Fujiya T; Department of Gastroenterology, Tohoku University Graduate School of Medicine.
Sugisawa J; Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine.
Suda A; Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine.
Sato K; Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine.
Ikeda S; Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine.
Shindo T; Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine.
Kikuchi Y; Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine.
Hao K; Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine.
Takahashi J; Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine.
Hatta W; Department of Gastroenterology, Tohoku University Graduate School of Medicine.
Koike T; Department of Gastroenterology, Tohoku University Graduate School of Medicine.
Masamune A; Department of Gastroenterology, Tohoku University Graduate School of Medicine.
Saiki Y; Department of Cardiovascular Surgery, Tohoku University Graduate school of Medicine.
Horiuchi H; Department of Molecular and Cellular Biology, Institute of Development, Aging, and Cancer, Tohoku University.
Shimokawa H; Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine.
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Źródło :
Journal of atherosclerosis and thrombosis [J Atheroscler Thromb] 2020 Mar 01; Vol. 27 (3), pp. 271-277. Date of Electronic Publication: 2019 Aug 03.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Anemia*/diagnosis
Anemia*/etiology
Anemia*/therapy
Angiodysplasia*/blood
Angiodysplasia*/complications
Angiodysplasia*/diagnostic imaging
Angiodysplasia*/therapy
Gastrointestinal Hemorrhage*/diagnosis
Gastrointestinal Hemorrhage*/etiology
Gastrointestinal Hemorrhage*/therapy
Stomach*/blood supply
Stomach*/diagnostic imaging
Aortic Valve Stenosis/*surgery
Gastroscopy/*methods
Transcatheter Aortic Valve Replacement/*methods
Aged, 80 and over ; Aortic Valve Stenosis/diagnosis ; Aortic Valve Stenosis/physiopathology ; Blood Transfusion/methods ; Female ; Hemostasis, Surgical/methods ; Humans ; Protein Multimerization ; Severity of Illness Index ; Treatment Outcome ; von Willebrand Factor/analysis
Czasopismo naukowe
Tytuł :
[Acquired von Willebrand syndrome: a hemostatic disorder frequently encountered in the fields of cardiology and gastroenterology].
Autorzy :
Horiuchi H; Department of Molecular and Cellular Biology, Institute of Development, Aging and Cancer, Tohoku University.
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Źródło :
[Rinsho ketsueki] The Japanese journal of clinical hematology [Rinsho Ketsueki] 2020; Vol. 61 (5), pp. 542-548.
Typ publikacji :
Journal Article
MeSH Terms :
Cardiology*
Gastroenterology*
Hemostatic Disorders*
von Willebrand Diseases*
Humans ; von Willebrand Factor
Czasopismo naukowe
Tytuł :
Down-regulation of RalGTPase-Activating Protein Promotes Colitis-Associated Cancer via NLRP3 Inflammasome Activation.
Autorzy :
Iida T; Department of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Sapporo, Japan.
Hirayama D; Department of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Sapporo, Japan.
Minami N; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Matsuura M; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Wagatsuma K; Department of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Sapporo, Japan.
Kawakami K; Department of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Sapporo, Japan.
Nagaishi K; Second Department of Anatomy, Sapporo Medical University School of Medicine, Sapporo, Japan.
Nojima M; Center for Translational Research, The Institute of Medical Science Hospital, The University of Tokyo, Tokyo, Japan.
Ikeuchi H; Division of Lower Gastrointestinal, Department of Surgery, Hyogo College of Medicine, Nishinomiya, Japan; Inflammatory Bowel Disease Center, Hyogo College of Medicine, Nishinomiya, Japan.
Hirota S; Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Japan.
Shirakawa R; Department of Molecular and Cellular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Horiuchi H; Department of Molecular and Cellular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Nakase H; Department of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Sapporo, Japan. Electronic address: .
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Źródło :
Cellular and molecular gastroenterology and hepatology [Cell Mol Gastroenterol Hepatol] 2020; Vol. 9 (2), pp. 277-293. Date of Electronic Publication: 2019 Oct 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Czasopismo naukowe
Tytuł :
Downregulation of RalGTPase-activating protein promotes invasion of prostatic epithelial cells and progression from intraepithelial neoplasia to cancer during prostate carcinogenesis.
Autorzy :
Uegaki M; Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Kita Y; Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Shirakawa R; Department of Molecular and Cellular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Miyagi, Japan.
Teramoto Y; Department of Diagnostic Pathology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Kamiyama Y; Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Saito R; Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Yoshikawa T; Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Sakamoto H; Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Goto T; Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Akamatsu S; Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Yamasaki T; Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Inoue T; Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Suzuki A; Division of Molecular and Cellular Biology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
Horiuchi H; Department of Molecular and Cellular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Miyagi, Japan.
Ogawa O; Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Kobayashi T; Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
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Źródło :
Carcinogenesis [Carcinogenesis] 2019 Dec 31; Vol. 40 (12), pp. 1535-1544.
Typ publikacji :
Journal Article
MeSH Terms :
Adenocarcinoma/*pathology
GTPase-Activating Proteins/*metabolism
Neoplasm Invasiveness/*pathology
Prostatic Intraepithelial Neoplasia/*pathology
Prostatic Neoplasms/*pathology
Adenocarcinoma/metabolism ; Animals ; Carcinogenesis/metabolism ; Carcinogenesis/pathology ; Cell Line, Tumor ; Disease Progression ; Down-Regulation ; Epithelial Cells/metabolism ; Epithelial Cells/pathology ; Humans ; Male ; Mice ; Prostatic Intraepithelial Neoplasia/metabolism ; Prostatic Neoplasms/metabolism
Czasopismo naukowe
Tytuł :
Inhibitor of Growth 4 (ING4) is a positive regulator of rRNA synthesis.
Autorzy :
Trinh DA; Department of Oral Cancer Therapeutics, Graduate School of Dentistry, Tohoku University, Sendai, Japan.; Department of Molecular and Cellular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Shirakawa R; Department of Molecular and Cellular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Kimura T; Department of Molecular and Cellular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.; Research Center for Molecular Genetics, Institute for Promotion of Medical Science Research, Yamagata University Faculty of Medicine, Yamagata, Yamagata, Japan.
Sakata N; Department of Molecular and Cellular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Goto K; Department of Molecular and Cellular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Horiuchi H; Department of Oral Cancer Therapeutics, Graduate School of Dentistry, Tohoku University, Sendai, Japan. hisanori.horiuchi..; Department of Molecular and Cellular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan. hisanori.horiuchi..
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Źródło :
Scientific reports [Sci Rep] 2019 Nov 21; Vol. 9 (1), pp. 17235. Date of Electronic Publication: 2019 Nov 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Cycle Proteins/*genetics
Homeodomain Proteins/*genetics
RNA, Ribosomal/*genetics
Tumor Suppressor Proteins/*genetics
Acetylation ; Cell Line, Tumor ; Cell Nucleus/genetics ; DNA, Ribosomal/genetics ; HeLa Cells ; Histones/genetics ; Humans ; Promoter Regions, Genetic/genetics ; Transcription, Genetic/genetics
Czasopismo naukowe
Tytuł :
Acquired von Willebrand syndrome in patients treated with veno-arterial extracorporeal membrane oxygenation.
Autorzy :
Tamura T; Department of Cardiology, Tenri Hospital, 200 Mishima-cho, Tenri, Nara, 632-8552, Japan. .
Horiuchi H; Department of Molecular and Cellular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Obayashi Y; Department of Cardiology, Tenri Hospital, 200 Mishima-cho, Tenri, Nara, 632-8552, Japan.
Fuki M; Department of Cardiology, Tenri Hospital, 200 Mishima-cho, Tenri, Nara, 632-8552, Japan.
Imanaka M; Department of Cardiology, Tenri Hospital, 200 Mishima-cho, Tenri, Nara, 632-8552, Japan.
Kuroda M; Department of Cardiology, Tenri Hospital, 200 Mishima-cho, Tenri, Nara, 632-8552, Japan.
Nishimura S; Department of Cardiology, Tenri Hospital, 200 Mishima-cho, Tenri, Nara, 632-8552, Japan.
Amano M; Department of Cardiology, Tenri Hospital, 200 Mishima-cho, Tenri, Nara, 632-8552, Japan.
Sakamoto J; Department of Cardiology, Tenri Hospital, 200 Mishima-cho, Tenri, Nara, 632-8552, Japan.
Tamaki Y; Department of Cardiology, Tenri Hospital, 200 Mishima-cho, Tenri, Nara, 632-8552, Japan.
Enomoto S; Department of Cardiology, Tenri Hospital, 200 Mishima-cho, Tenri, Nara, 632-8552, Japan.
Miyake M; Department of Cardiology, Tenri Hospital, 200 Mishima-cho, Tenri, Nara, 632-8552, Japan.
Kondo H; Department of Cardiology, Tenri Hospital, 200 Mishima-cho, Tenri, Nara, 632-8552, Japan.
Izumi C; Department of Cardiology, Tenri Hospital, 200 Mishima-cho, Tenri, Nara, 632-8552, Japan.
Nakagawa Y; Department of Cardiology, Tenri Hospital, 200 Mishima-cho, Tenri, Nara, 632-8552, Japan.
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Źródło :
Cardiovascular intervention and therapeutics [Cardiovasc Interv Ther] 2019 Oct; Vol. 34 (4), pp. 358-363. Date of Electronic Publication: 2019 Jan 17.
Typ publikacji :
Journal Article
MeSH Terms :
Extracorporeal Membrane Oxygenation/*adverse effects
von Willebrand Diseases/*etiology
Adult ; Aged ; Female ; Gastrointestinal Hemorrhage/etiology ; Hemothorax/etiology ; Humans ; Male ; Middle Aged ; Myocardial Infarction/therapy ; Myocarditis/therapy ; Pulmonary Embolism/therapy
Czasopismo naukowe
Tytuł :
Acquired von Willebrand syndrome in patients treated with veno-arterial extracorporeal membrane oxygenation.
Autorzy :
Tamura, Toshihiro
Horiuchi, Hisanori
Obayashi, Yuki
Fuki, Masayuki
Imanaka, Miyako
Kuroda, Maiko
Nishimura, Shunsuke
Amano, Masashi
Sakamoto, Jiro
Tamaki, Yodo
Enomoto, Soichiro
Miyake, Makoto
Kondo, Hirokazu
Izumi, Chisato
Nakagawa, Yoshihisa
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Źródło :
Cardiovascular Intervention & Therapeutics; Oct2019, Vol. 34 Issue 4, p358-363, 6p
Czasopismo naukowe
Tytuł :
Acquired von Willebrand Syndrome Associated with Cardiovascular Diseases.
Autorzy :
Horiuchi H; Department of Molecular and Cellular Biology, Institute of Development, Aging and Cancer, Tohoku University.
Doman T; Department of Molecular and Cellular Biology, Institute of Development, Aging and Cancer, Tohoku University.
Kokame K; Department of Molecular Pathogenesis, National Cerebral and Cardiovascular Center.
Saiki Y; Division of Cardiovascular Surgery, Tohoku University Graduate School of Medicine.
Matsumoto M; Department of Blood Transfusion Medicine, Nara Medical University.
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Źródło :
Journal of atherosclerosis and thrombosis [J Atheroscler Thromb] 2019 Apr 01; Vol. 26 (4), pp. 303-314. Date of Electronic Publication: 2019 Mar 12.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Cardiovascular Diseases/*pathology
von Willebrand Diseases/*pathology
von Willebrand Factor/*metabolism
Animals ; Cardiovascular Diseases/complications ; Cardiovascular Diseases/metabolism ; Humans ; Prognosis ; von Willebrand Diseases/complications ; von Willebrand Diseases/metabolism
Czasopismo naukowe
Tytuł :
Abstract 15658: Significant Individual Variability in von Willbrand Factor Fragility in Response to Shear Stress-A Possible Clue to Predict Bleeding Risk After Left Ventricular Assist Device Implantation.
Autorzy :
Sakatsume, Ko (AUTHOR)
Akiyama, Masatoshi (AUTHOR)
Sasaki, Konosuke (AUTHOR)
Suzuki, Yusuke (AUTHOR)
Yoshioka, Ichiro (AUTHOR)
Kumagai, Kiichiro (AUTHOR)
Adachi, Osamu (AUTHOR)
Horiuchi, Hisanori (AUTHOR)
Maruyama, Osamu (AUTHOR)
Saiki, Yoshikatsu (AUTHOR)
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Źródło :
Circulation. 2018 Supplement, Vol. 138, pA15658-A15658. 1p.
Czasopismo naukowe
Tytuł :
Association between the severity of acquired von Willebrand syndrome and gastrointestinal bleeding after continuous-flow left ventricular assist device implantation.
Autorzy :
Sakatsume K; Division of Cardiovascular Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.; Department of Molecular and Cellular Biology, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan.
Saito K; Department of Molecular and Cellular Biology, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan.
Akiyama M; Division of Cardiovascular Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Sasaki K; Division of Cardiovascular Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Kawatsu S; Division of Cardiovascular Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Takahashi G; Division of Cardiovascular Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Adachi O; Division of Cardiovascular Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Kawamoto S; Division of Cardiovascular Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Horiuchi H; Department of Molecular and Cellular Biology, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan.
Saiki Y; Division of Cardiovascular Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
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Źródło :
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery [Eur J Cardiothorac Surg] 2018 Nov 01; Vol. 54 (5), pp. 841-846.
Typ publikacji :
Journal Article
MeSH Terms :
Gastrointestinal Hemorrhage/*etiology
Heart-Assist Devices/*adverse effects
von Willebrand Diseases/*etiology
Adult ; Biomarkers/blood ; Female ; Follow-Up Studies ; Gastrointestinal Hemorrhage/blood ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Prosthesis Design ; Severity of Illness Index ; von Willebrand Diseases/blood ; von Willebrand Factor/analysis
Czasopismo naukowe
Tytuł :
C2 Domains of Munc13-4 Are Crucial for Ca -Dependent Degranulation and Cytotoxicity in NK Cells.
Autorzy :
Bin NR; Division of Fundamental Neurobiology, Krembil Research Institute, University Health Network, Toronto, Ontario M5T 2S8, Canada.; Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Ma K; Division of Fundamental Neurobiology, Krembil Research Institute, University Health Network, Toronto, Ontario M5T 2S8, Canada.; Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Tien CW; Division of Fundamental Neurobiology, Krembil Research Institute, University Health Network, Toronto, Ontario M5T 2S8, Canada.; Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Wang S; Division of Fundamental Neurobiology, Krembil Research Institute, University Health Network, Toronto, Ontario M5T 2S8, Canada.; Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Zhu D; Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.; Department of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Park S; Division of Fundamental Neurobiology, Krembil Research Institute, University Health Network, Toronto, Ontario M5T 2S8, Canada.; Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Turlova E; Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.; Department of Surgery, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Sugita K; Division of Genetics and Development, Krembil Research Institute, University Health Network, Toronto, Ontario M5T 2S8, Canada.
Shirakawa R; Department of Molecular and Cellular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan; and.
van der Sluijs P; Department of Cell Biology, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands.
Horiuchi H; Department of Molecular and Cellular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan; and.
Sun HS; Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.; Department of Surgery, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Monnier PP; Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.; Division of Genetics and Development, Krembil Research Institute, University Health Network, Toronto, Ontario M5T 2S8, Canada.
Gaisano HY; Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.; Department of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Sugita S; Division of Fundamental Neurobiology, Krembil Research Institute, University Health Network, Toronto, Ontario M5T 2S8, Canada; .; Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
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Źródło :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2018 Jul 15; Vol. 201 (2), pp. 700-713. Date of Electronic Publication: 2018 Jun 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Killer Cells, Natural/*immunology
Lymphohistiocytosis, Hemophagocytic/*immunology
Mast Cells/*immunology
Membrane Proteins/*metabolism
Secretory Vesicles/*metabolism
Animals ; Aspartic Acid/genetics ; Calcium Signaling ; Cell Degranulation ; Cells, Cultured ; Cytotoxicity, Immunologic ; Humans ; Mice ; Mice, Inbred C57BL ; Mice, Mutant Strains ; Mutation/genetics ; Protein Domains/genetics ; Rats
Czasopismo naukowe
Tytuł :
Impact of Baseline Thrombocytopenia on Bleeding and Mortality After Percutaneous Coronary Intervention.
Autorzy :
Ito S; Division of Cardiology, Kokura Memorial Hospital, Kitakyusyu, Japan.
Watanabe H; Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Morimoto T; Department of Clinical Epidemiology, Hyogo College of Medicine, Nishinomiya, Japan.
Yoshikawa Y; Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Shiomi H; Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Shizuta S; Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Ono K; Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Yamaji K; Division of Cardiology, Kokura Memorial Hospital, Kitakyusyu, Japan.
Soga Y; Division of Cardiology, Kokura Memorial Hospital, Kitakyusyu, Japan.
Hyodo M; Division of Cardiology, Kokura Memorial Hospital, Kitakyusyu, Japan.
Shirai S; Division of Cardiology, Kokura Memorial Hospital, Kitakyusyu, Japan.
Ando K; Division of Cardiology, Kokura Memorial Hospital, Kitakyusyu, Japan.
Horiuchi H; Department of Molecular and Cellular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Kimura T; Division of Cardiology, Kokura Memorial Hospital, Kitakyusyu, Japan. Electronic address: .
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Źródło :
The American journal of cardiology [Am J Cardiol] 2018 Jun 01; Vol. 121 (11), pp. 1304-1314. Date of Electronic Publication: 2018 Mar 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mortality*
Percutaneous Coronary Intervention*
Postoperative Hemorrhage/*epidemiology
ST Elevation Myocardial Infarction/*surgery
Thrombocytopenia/*epidemiology
Aged ; Aged, 80 and over ; Female ; Humans ; Japan/epidemiology ; Male ; Middle Aged ; Myocardial Infarction/epidemiology ; Platelet Count ; Postoperative Complications/epidemiology ; Proportional Hazards Models ; Risk Factors ; ST Elevation Myocardial Infarction/blood ; ST Elevation Myocardial Infarction/epidemiology ; Stroke/epidemiology
Czasopismo naukowe
Tytuł :
Human CTL-based functional analysis shows the reliability of a munc13-4 protein expression assay for FHL3 diagnosis.
Autorzy :
Shibata H; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Yasumi T; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Shimodera S; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Hiejima E; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Izawa K; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Kawai T; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Shirakawa R; Department of Molecular and Cellular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Wada T; Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.
Nishikomori R; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Horiuchi H; Department of Molecular and Cellular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Ohara O; Laboratory for Integrative Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Kazusa DNA Research Institute, Kisarazu, Japan; and.
Ishii E; Department of Pediatrics, Graduate School of Medicine, Ehime University, Toon, Japan.
Heike T; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
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Źródło :
Blood [Blood] 2018 May 03; Vol. 131 (18), pp. 2016-2025. Date of Electronic Publication: 2018 Mar 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression*
Lymphohistiocytosis, Hemophagocytic/*diagnosis
Lymphohistiocytosis, Hemophagocytic/*etiology
Membrane Proteins/*genetics
T-Lymphocytes, Cytotoxic/*immunology
Alleles ; Amino Acid Substitution ; Biomarkers ; Cell Line ; Flow Cytometry ; Genotype ; Humans ; Membrane Proteins/metabolism ; Molecular Diagnostic Techniques ; Mutation ; T-Lymphocytes, Cytotoxic/metabolism
SCR Disease Name :
Hemophagocytic lymphohistiocytosis, familial, 3
Czasopismo naukowe

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