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Tytuł :
Long-term Safety of Growth Hormone in Adults With Growth Hormone Deficiency: Overview of 15 809 GH-Treated Patients.
Autorzy :
Johannsson G; Department of Endocrinology, Sahlgrenska University Hospital & Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, SE-413 45, Gothenburg, Sweden.
Touraine P; Department of Endocrinology and Reproductive Medicine, Center for Rare Endocrine and Gynecological Disorders, Sorbonne Université, Assistance Publique Hopitaux de Paris, Paris, France.
Feldt-Rasmussen U; Department of Endocrinology and Metabolism, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Clinical Science, Copenhagen University, Copenhagen, Denmark.
Pico A; Biomedical Research Networking Center in Rare Diseases (CIBERER), Institute of Health Carlos III (ISCIII), Madrid, Spain.; Hospital General Universitario de Alicante-Institute for Health and Biomedical Research (ISABIAL), Alicante, Spain.; Department of Clinical Medicine, Miguel Hernández University, Elche, Spain.
Vila G; Clinical Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
Mattsson AF; Pfizer Endocrine Care, Pfizer Health AB, Sollentuna, Sweden.
Carlsson M; Rare Disease, Biopharmaceuticals, Pfizer, New York, NY, USA.
Korbonits M; Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
van Beek AP; Department of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Wajnrajch MP; Rare Disease, Biopharmaceuticals, Pfizer, New York, NY, USA.; Department of Pediatrics, New York University Langone Medical Center, New York, NY, USA.
Gomez R; European Medical Affairs, Pfizer, Brussels, Belgium.
Yuen KCJ; Barrow Pituitary Center, Barrow Neurological Institute, University of Arizona College of Medicine and Creighton School of Medicine, Phoenix, AZ, USA.
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Źródło :
The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2022 Jun 16; Vol. 107 (7), pp. 1906-1919.
Typ publikacji :
Journal Article
MeSH Terms :
Dwarfism, Pituitary*/complications
Dwarfism, Pituitary*/drug therapy
Dwarfism, Pituitary*/epidemiology
Human Growth Hormone*/adverse effects
Hypopituitarism*/drug therapy
Hypopituitarism*/epidemiology
Pituitary Diseases*/etiology
Pituitary Neoplasms*/drug therapy
Adolescent ; Adult ; Child ; Growth Hormone/therapeutic use ; Hormone Replacement Therapy/adverse effects ; Humans ; Quality of Life
Czasopismo naukowe
Tytuł :
Increased testicular insulin-like growth factor 1 is associated with gonadal activation by recombinant growth hormone in immature rats.
Autorzy :
Xu Y; Department of Life Science and Institute for Natural Sciences, Hanyang University, Seoul, 04760, Korea.
Han CY; Department of Life Science and Institute for Natural Sciences, Hanyang University, Seoul, 04760, Korea.
Park MJ; Department of Pediatrics, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, 01757, Korea. .
Gye MC; Department of Life Science and Institute for Natural Sciences, Hanyang University, Seoul, 04760, Korea. .
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Źródło :
Reproductive biology and endocrinology : RB&E [Reprod Biol Endocrinol] 2022 Apr 23; Vol. 20 (1), pp. 72. Date of Electronic Publication: 2022 Apr 23.
Typ publikacji :
Journal Article
MeSH Terms :
Human Growth Hormone*/pharmacology
Insulin-Like Growth Factor I*/genetics
Insulin-Like Growth Factor I*/metabolism
Insulin-Like Growth Factor I*/pharmacology
Testis*/metabolism
Animals ; Gonadotropin-Releasing Hormone/metabolism ; Growth Hormone/genetics ; Growth Hormone/metabolism ; Growth Hormone/pharmacology ; Kisspeptins/metabolism ; Male ; RNA, Messenger/metabolism ; Rats ; Testosterone
Czasopismo naukowe
Tytuł :
Exogenous growth hormone functionally alleviates glucocorticoid-induced longitudinal bone growth retardation in male rats by activating the Ihh/PTHrP signaling pathway.
Autorzy :
Peng G; Department of Emergency Surgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, 550001, China; School of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou, 550025, China; Department of Orthopedics, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, 550001, China. Electronic address: .
Sun H; School of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou, 550025, China; Department of Orthopedics, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, 550001, China. Electronic address: .
Jiang H; Department of Pediatric Orthopaedic, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, 550001, China. Electronic address: .
Wang Q; Department of Emergency Surgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, 550001, China; School of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou, 550025, China. Electronic address: .
Gan L; Department of Emergency Surgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, 550001, China; School of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou, 550025, China. Electronic address: .
Tian Y; School of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou, 550025, China. Electronic address: .
Sun J; Wound Trauma Medical Center, State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Army Medical University, Chongqing, 400042, China. Electronic address: .
Wen D; Wound Trauma Medical Center, State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Army Medical University, Chongqing, 400042, China. Electronic address: .
Deng J; Department of Emergency Surgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, 550001, China. Electronic address: .
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Źródło :
Molecular and cellular endocrinology [Mol Cell Endocrinol] 2022 Apr 05; Vol. 545, pp. 111571. Date of Electronic Publication: 2022 Jan 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Glucocorticoids*/adverse effects
Glucocorticoids*/metabolism
Parathyroid Hormone-Related Protein*/metabolism
Parathyroid Hormone-Related Protein*/pharmacology
Animals ; Cell Differentiation ; Child ; Chondrocytes/metabolism ; Growth Disorders/metabolism ; Growth Hormone/metabolism ; Growth Hormone/pharmacology ; Growth Plate/metabolism ; Hedgehog Proteins/metabolism ; Humans ; Male ; Rats ; Receptor, Parathyroid Hormone, Type 1/metabolism ; Signal Transduction ; Trans-Activators/metabolism
Czasopismo naukowe
Tytuł :
The role of growth hormone for fertility in women with hypopituitarism.
Autorzy :
Chen J; Department of Medicine, Division of Endocrinology & Metabolism, Stanford University School of Medicine, 300 Pasteur Drive, Grant-S025, Stanford, CA 94305-5103, United States of America. Electronic address: .
Katznelson L; Neurosurgery and Medicine (Endocrinology and Metabolism), Stanford University School of Medicine, 300 Pasteur Drive, Grant-S025, Stanford, CA 94305-5103, United States of America.
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Źródło :
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society [Growth Horm IGF Res] 2022 Apr; Vol. 63, pp. 101458. Date of Electronic Publication: 2022 Mar 29.
Typ publikacji :
Journal Article
MeSH Terms :
Human Growth Hormone*/pharmacology
Human Growth Hormone*/therapeutic use
Hypopituitarism*/drug therapy
Female ; Fertility ; Growth Hormone/pharmacology ; Hormone Replacement Therapy ; Humans ; Pregnancy
Czasopismo naukowe
Tytuł :
Effects of adult growth hormone deficiency and replacement therapy on the cardiometabolic risk profile.
Autorzy :
Ratku B; Department of Emergency Medicine, Faculty of Medicine, University of Debrecen, Egyetem tér 1, Debrecen, 4032, Hungary.; Doctoral School of Health Sciences, University of Debrecen, Debrecen, Hungary.; Department of Emergency and Oxyology, Faculty of Health, University of Debrecen, Debrecen, Hungary.
Sebestyén V; Department of Emergency Medicine, Faculty of Medicine, University of Debrecen, Egyetem tér 1, Debrecen, 4032, Hungary.; Doctoral School of Health Sciences, University of Debrecen, Debrecen, Hungary.
Erdei A; Division of Endocrinology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Nagy EV; Division of Endocrinology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Szabó Z; Department of Emergency Medicine, Faculty of Medicine, University of Debrecen, Egyetem tér 1, Debrecen, 4032, Hungary.
Somodi S; Department of Emergency Medicine, Faculty of Medicine, University of Debrecen, Egyetem tér 1, Debrecen, 4032, Hungary. .; Division of Endocrinology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary. .
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Źródło :
Pituitary [Pituitary] 2022 Apr; Vol. 25 (2), pp. 211-228. Date of Electronic Publication: 2022 Feb 01.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Atherosclerosis*
Dwarfism, Pituitary*
Human Growth Hormone*/therapeutic use
Adult ; Child ; Growth Hormone ; Hormone Replacement Therapy ; Humans
Czasopismo naukowe
Tytuł :
Dapagliflozin partially restores reproductive function in MC4R KO obese female mice.
Autorzy :
Cui L; School of Biomedical Science, University of Queensland, St Lucia, Brisbane, Queensland, Australia.; Department of Reproduction and Infertility, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Tan C; School of Biomedical Science, University of Queensland, St Lucia, Brisbane, Queensland, Australia.
Huang L; School of Biomedical Science, University of Queensland, St Lucia, Brisbane, Queensland, Australia.
Wang W; School of Biomedical Science, University of Queensland, St Lucia, Brisbane, Queensland, Australia.
Huang Z; School of Biomedical Science, University of Queensland, St Lucia, Brisbane, Queensland, Australia.
Geng F; School of Biomedical Science, University of Queensland, St Lucia, Brisbane, Queensland, Australia.
Wu M; Department of Reproduction and Infertility, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Chen X; Endocrinology Department, Renmin Hospital of Wuhan University, Wuchang District, Wuhan, Hubei Province, China.
Cowley M; Department of Physiology, Monash University, Clayton, Victoria, Australia.
Roelfsema F; Endocrinology and Metabolism, Leiden University, Leiden, Netherlands.
Chen C; School of Biomedical Science, University of Queensland, St Lucia, Brisbane, Queensland, Australia.
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Źródło :
The Journal of endocrinology [J Endocrinol] 2022 Jun 17; Vol. 254 (2), pp. 65-76. Date of Electronic Publication: 2022 Jun 17.
Typ publikacji :
Journal Article
MeSH Terms :
Human Growth Hormone*
Receptor, Melanocortin, Type 4*/genetics
Receptor, Melanocortin, Type 4*/metabolism
Animals ; Benzhydryl Compounds/pharmacology ; Female ; Glucosides/pharmacology ; Growth Hormone/metabolism ; Humans ; Hyperphagia ; Luteinizing Hormone ; Mice ; Mice, Knockout ; Obesity/complications ; Obesity/drug therapy ; Obesity/genetics
Czasopismo naukowe
Tytuł :
Critical Extracellular Ca Dependence of the Binding between PTH1R and a G-Protein Peptide Revealed by MD Simulations.
Autorzy :
Li M; College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, China.
Bao Y; College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, China.
Xu R; College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, China.
La H; College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, China.
Guo J; College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, China.; Engineering Research Centre of Applied Technology on Machine Translation and Artificial Intelligence, Faculty of Applied Science, Macao Polytechnic University, Macao 999078, China.
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Źródło :
ACS chemical neuroscience [ACS Chem Neurosci] 2022 Jun 01; Vol. 13 (11), pp. 1666-1674. Date of Electronic Publication: 2022 May 11.
Typ publikacji :
Journal Article
MeSH Terms :
Calcium*/metabolism
Parathyroid Hormone*/chemistry
Parathyroid Hormone*/metabolism
GTP-Binding Proteins/metabolism ; Molecular Dynamics Simulation ; Receptor, Parathyroid Hormone, Type 1/chemistry ; Receptor, Parathyroid Hormone, Type 1/metabolism
Czasopismo naukowe
Tytuł :
The p300 Inhibitor A-485 Exerts Antitumor Activity in Growth Hormone Pituitary Adenoma.
Autorzy :
Ji C; Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, National Center for Neurological Disorders, Shanghai, China.; Neurosurgical Institute of Fudan University, Shanghai, China.
Xu W; Hospital & Institute of Obstetrics and Gynecology, Fudan University, Shanghai, China.
Ding H; Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, China.; Drug Discovery and Design Center, CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Chen Z; Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, National Center for Neurological Disorders, Shanghai, China.; Neurosurgical Institute of Fudan University, Shanghai, China.
Shi C; Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, National Center for Neurological Disorders, Shanghai, China.; Neurosurgical Institute of Fudan University, Shanghai, China.
Han J; Drug Discovery and Design Center, CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Yu L; Drug Discovery and Design Center, CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Qiao N; Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, National Center for Neurological Disorders, Shanghai, China.; Neurosurgical Institute of Fudan University, Shanghai, China.; Shanghai Key laboratory of Brain Function Restoration and Neural Regeneration, Shanghai, China.
Zhang Y; Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, National Center for Neurological Disorders, Shanghai, China.; Neurosurgical Institute of Fudan University, Shanghai, China.; Shanghai Key laboratory of Brain Function Restoration and Neural Regeneration, Shanghai, China.
Cao X; Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, National Center for Neurological Disorders, Shanghai, China.; Neurosurgical Institute of Fudan University, Shanghai, China.; Shanghai Key laboratory of Brain Function Restoration and Neural Regeneration, Shanghai, China.
Zhou X; Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, National Center for Neurological Disorders, Shanghai, China.; Neurosurgical Institute of Fudan University, Shanghai, China.; Shanghai Key laboratory of Brain Function Restoration and Neural Regeneration, Shanghai, China.
Cheng H; Department of Pathology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Feng H; Department of Medicinal Chemistry, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Luo C; Drug Discovery and Design Center, CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Li Z; Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, China.
Zhou B; Department of Medicinal Chemistry, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, UCAS, Hangzhou, China.
Ye Z; Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, National Center for Neurological Disorders, Shanghai, China.; Neurosurgical Institute of Fudan University, Shanghai, China.; Shanghai Key laboratory of Brain Function Restoration and Neural Regeneration, Shanghai, China.
Zhao Y; Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, National Center for Neurological Disorders, Shanghai, China.; Neurosurgical Institute of Fudan University, Shanghai, China.; Shanghai Key laboratory of Brain Function Restoration and Neural Regeneration, Shanghai, China.; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, China.; National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China.
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Źródło :
The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2022 May 17; Vol. 107 (6), pp. e2291-e2300.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenoma*/drug therapy
Adenoma*/genetics
Adenoma*/metabolism
Growth Hormone-Secreting Pituitary Adenoma*/genetics
Human Growth Hormone*/therapeutic use
Pituitary Neoplasms*/drug therapy
Pituitary Neoplasms*/genetics
Pituitary Neoplasms*/metabolism
Carcinogenesis ; Cell Line, Tumor ; Cell Proliferation ; Growth Hormone/therapeutic use ; Humans ; Phosphatidylinositol 3-Kinases
Czasopismo naukowe
Tytuł :
Proteomic Analysis of the Intestinal Resistance to Thyroid Hormone Mouse Model With Thyroid Hormone Receptor Alpha Mutations.
Autorzy :
Xi Y; Department of Endocrinology and Metabolism, Endocrine Institute, and Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Hospital of China Medical University, Shenyang, China.; Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.
Zhang D; Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.
Liang Y; Department of Endocrinology and Metabolism, Endocrine Institute, and Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Hospital of China Medical University, Shenyang, China.
Shan Z; Department of Endocrinology and Metabolism, Endocrine Institute, and Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Hospital of China Medical University, Shenyang, China.
Teng X; Department of Endocrinology and Metabolism, Endocrine Institute, and Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Hospital of China Medical University, Shenyang, China.
Teng W; Department of Endocrinology and Metabolism, Endocrine Institute, and Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Hospital of China Medical University, Shenyang, China.
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Źródło :
Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2022 Apr 28; Vol. 13, pp. 773516. Date of Electronic Publication: 2022 Apr 28 (Print Publication: 2022).
Typ publikacji :
Journal Article
MeSH Terms :
Thyroid Hormone Resistance Syndrome*/genetics
Animals ; Disease Models, Animal ; Humans ; Intestines ; Mice ; Mutation ; Proteomics ; Receptors, Thyroid Hormone/genetics ; Thyroid Hormone Receptors alpha/genetics ; Thyroid Hormone Receptors alpha/metabolism ; Thyroid Hormones ; Triiodothyronine
Czasopismo naukowe
Tytuł :
The Origination of Growth Hormone/Insulin-Like Growth Factor System: A Story From Ancient Basal Chordate Amphioxus.
Autorzy :
Li M; School of Basic Medical Sciences, Qingdao University, Qingdao, China.
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Źródło :
Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2022 Apr 01; Vol. 13, pp. 825722. Date of Electronic Publication: 2022 Apr 01 (Print Publication: 2022).
Typ publikacji :
Journal Article; Review
MeSH Terms :
Human Growth Hormone*/metabolism
Lancelets*/genetics
Lancelets*/metabolism
Animals ; Growth Hormone/genetics ; Growth Hormone/metabolism ; Insulin-Like Growth Factor Binding Proteins/genetics ; Insulin-Like Growth Factor Binding Proteins/metabolism ; Protein Binding ; Vertebrates/metabolism
Czasopismo naukowe
Tytuł :
Safety and Efficacy of Lonapegsomatropin in Children With Growth Hormone Deficiency: enliGHten Trial 2-Year Results.
Autorzy :
Maniatis AK; Rocky Mountain Pediatric Endocrinology, Centennial, CO, USA.
Casella SJ; Children's Hospital at Dartmouth-Hitchcock, LebanonNH, USA.
Nadgir UM; Center of Excellence in Diabetes and Endocrinology, Sacramento, CA, USA.
Hofman PL; Liggins Institute, University of Auckland, Auckland, New Zealand.
Saenger P; NYU Langone Health, New York, NY, USA.
Chertock ED; Voronezh State Medical University, Voronezh, Russia.
Aghajanova EM; Yerevan State Medical University, Yerevan, Armenia.
Korpal-Szczyrska M; Klinika Pediatrii, Diabetologii i Endokrynologii Uniwersyteckie Centrum Kliniczne, Gdansk, Poland.
Vlachopapadopoulou E; Children's Hospital. P. A. Kyriakou, Athens, Greece.
Malievskiy O; Bashkir State Medical University, Ufa, Russia.
Chaychenko T; MHI Regional Child Clinical Hospital, Child Endocrinology Center, Kharkiv National Medical University, Kharkiv, Ukraine.
Cappa M; UOC di Endocrinologia, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy.
Song W; Ascendis Pharma, Palo Alto, CA, USA.
Mao M; Ascendis Pharma, Palo Alto, CA, USA.
Mygind PH; Ascendis Pharma, Palo Alto, CA, USA.
Smith AR; Ascendis Pharma, Palo Alto, CA, USA.
Chessler SD; Ascendis Pharma, Palo Alto, CA, USA.
Komirenko AS; Ascendis Pharma, Palo Alto, CA, USA.
Beckert M; Ascendis Pharma A/S, Hellerup, Denmark.
Shu AD; Ascendis Pharma, Palo Alto, CA, USA.
Thornton PS; Cook Children's Health Care System, Fort Worth, TX, USA.
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Źródło :
The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2022 Jun 16; Vol. 107 (7), pp. e2680-e2689.
Typ publikacji :
Journal Article
MeSH Terms :
Dwarfism, Pituitary*
Human Growth Hormone*/adverse effects
Body Height ; Child ; Growth Disorders/drug therapy ; Growth Hormone ; Humans
Czasopismo naukowe
Tytuł :
Efficacy and Safety of Weekly Somatrogon vs Daily Somatropin in Children With Growth Hormone Deficiency: A Phase 3 Study.
Autorzy :
Deal CL; Centre de recherche CHU Ste-Justine, Université de Montréal, Montréal, Canada.
Steelman J; Cook Children's Medical Center, Fort Worth, TX, USA.
Vlachopapadopoulou E; Children's Hospital P. & A. Kyriakou, Athens, Greece.
Stawerska R; Polish Mother's Memorial Hospital-Research Institute, Lodz, and Medical University of Lodz, Lodz, Poland.
Silverman LA; Goryeb Children's Hospital, Atlantic Health System, Morristown, NJ, USA.
Phillip M; Schneider Children's Medical Center of Israel, Petah Tikva, and Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Kim HS; Yonsei University College of Medicine, Seoul, South Korea.
Ko C; Kyungpook National University Children's Hospital, Daegu, South Korea.
Malievskiy O; Bashkir State Medical University, Ufa, Russia.
Cara JF; Pfizer Inc, New York, NY, USA.
Roland CL; Pfizer Inc, Sanford, NC, USA.
Taylor CT; Pfizer Inc, New York, NY, USA.
Valluri SR; Pfizer Inc, New York, NY, USA.
Wajnrajch MP; Pfizer Inc, New York, NY, USA.; New York University Langone Medical Center, New York, NY, USA.
Pastrak A; OPKO Health, Miami, FL, USA.
Miller BS; University of Minnesota Masonic Children's Hospital, Minneapolis, MN, USA.
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Źródło :
The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2022 Jun 16; Vol. 107 (7), pp. e2717-e2728.
Typ publikacji :
Clinical Trial, Phase III; Journal Article; Randomized Controlled Trial
MeSH Terms :
Dwarfism, Pituitary*/drug therapy
Human Growth Hormone*/adverse effects
Body Height ; Child ; Female ; Growth Disorders/drug therapy ; Growth Hormone/therapeutic use ; Humans ; Male ; Recombinant Proteins/adverse effects
Czasopismo naukowe
Tytuł :
Formation of False Context Fear Memory Is Regulated by Hypothalamic Corticotropin-Releasing Factor in Mice.
Autorzy :
Kasama E; Department of Pharmacology, School of Pharmaceutical Science, Ohu University, 31-1 Misumido, Tomitamachi, Koriyama 963-8611, Fukushima, Japan.
Moriya M; Department of Pharmacology, School of Pharmaceutical Science, Ohu University, 31-1 Misumido, Tomitamachi, Koriyama 963-8611, Fukushima, Japan.
Kamimura R; Department of Pharmacology, School of Pharmaceutical Science, Ohu University, 31-1 Misumido, Tomitamachi, Koriyama 963-8611, Fukushima, Japan.
Matsuki T; Department of Cellular Pathology, Institute for Developmental Research, Aichi Developmental Disability Center, Kasugai 480-0392, Aichi, Japan.
Seki K; Department of Pharmacology, School of Pharmaceutical Science, Ohu University, 31-1 Misumido, Tomitamachi, Koriyama 963-8611, Fukushima, Japan.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2022 Jun 03; Vol. 23 (11). Date of Electronic Publication: 2022 Jun 03.
Typ publikacji :
Journal Article
MeSH Terms :
Adrenocorticotropic Hormone*/pharmacology
Corticotropin-Releasing Hormone*/metabolism
Animals ; Fear ; Freezing Reaction, Cataleptic/physiology ; Hypothalamo-Hypophyseal System/metabolism ; Mice ; Pituitary Hormone-Releasing Hormones/pharmacology ; Pituitary-Adrenal System/metabolism
Czasopismo naukowe
Tytuł :
A randomized, controlled, first-in-patient trial of choriogonadotropin beta added to follitropin delta in women undergoing ovarian stimulation in a long GnRH agonist protocol.
Autorzy :
Fernández Sánchez M; IVI-RMA Seville, Seville, Spain.; Departament of Surgery, Universidad de Sevilla, Seville, Spain.; Department of Molecular Biology and Biochemical Engineering, Universidad Pablo de Olavide, Seville, Spain.; Fundacion IVI, Instituto Investigación Sanitaria La Fe, Valencia, Spain.
Višnová H; IVF CUBE, Prague, Czech Republic.
Larsson P; Global Biometrics, Ferring Pharmaceuticals, Copenhagen, Denmark.
Yding Andersen C; Laboratory of Reproductive Biology, Copenhagen University Hospital and Faculty of Health Science, Copenhagen University, Copenhagen, Denmark.
Filicori M; GynePro Medical Group, Bologna, Italy.
Blockeel C; Centre for Reproductive Medicine, Universitair Ziekenhuis Brussel, Brussels, Belgium.
Pinborg A; Fertility Clinic, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Khalaf Y; Assisted Conception Unit, Guy's Hospital, London, UK.
Mannaerts B; Reproductive Medicine & Maternal Health, Ferring Pharmaceuticals, Copenhagen, Denmark.
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Corporate Authors :
Rainbow Study Group
Źródło :
Human reproduction (Oxford, England) [Hum Reprod] 2022 May 30; Vol. 37 (6), pp. 1161-1174.
Typ publikacji :
Clinical Trial Protocol; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Follicle Stimulating Hormone, Human*
Ovulation Induction*/methods
Animals ; Anti-Mullerian Hormone ; Body Weight ; CHO Cells ; Chorionic Gonadotropin ; Chorionic Gonadotropin, beta Subunit, Human ; Cricetinae ; Cricetulus ; Female ; Fertilization in Vitro/methods ; Gonadotropin-Releasing Hormone ; Humans ; Pharmaceutical Preparations ; Pregnancy ; Pregnancy Rate ; Randomized Controlled Trials as Topic ; Recombinant Proteins
Czasopismo naukowe
Tytuł :
A randomized clinical trial demonstrating cell type specific effects of hyperlipidemia and hyperinsulinemia on pituitary function.
Autorzy :
McDonald R; Department of Obstetrics and Gynecology, University of Colorado School of Medicine, Aurora, CO, United States of America.
Kuhn K; Department of Obstetrics and Gynecology, University of Colorado School of Medicine, Aurora, CO, United States of America.
Nguyen TB; Department of Obstetrics and Gynecology, University of Colorado School of Medicine, Aurora, CO, United States of America.
Tannous A; Department of Obstetrics and Gynecology, University of Colorado School of Medicine, Aurora, CO, United States of America.
Schauer I; Department of Medicine, Division of Endocrinology, Metabolism & Diabetes, University of Colorado School of Medicine, Aurora, CO, United States of America.; Endocrinology Section, Rocky Mountain Regional Veterans Affairs Medical Center, Aurora, CO, United States of America.
Santoro N; Department of Obstetrics and Gynecology, University of Colorado School of Medicine, Aurora, CO, United States of America.
Bradford AP; Department of Obstetrics and Gynecology, University of Colorado School of Medicine, Aurora, CO, United States of America.
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Źródło :
PloS one [PLoS One] 2022 May 11; Vol. 17 (5), pp. e0268323. Date of Electronic Publication: 2022 May 11 (Print Publication: 2022).
Typ publikacji :
Journal Article; Randomized Controlled Trial
MeSH Terms :
Human Growth Hormone*/metabolism
Hyperinsulinism*/complications
Hyperlipidemias*/complications
Hyperlipidemias*/drug therapy
Adiponectin ; Creatinine ; Cross-Over Studies ; Female ; Follicle Stimulating Hormone ; Growth Hormone ; Heparin ; Humans ; Hydrocortisone ; Insulin ; Insulin-Like Growth Factor I ; Leptin ; Lipids ; Luteinizing Hormone ; Obesity/complications ; Pituitary Hormones ; Pregnancy ; Prolactin ; Thyroid Hormones ; Thyrotropin/metabolism
Czasopismo naukowe
Tytuł :
Correlation of LH level and steroid concentrations in GnRH antagonist protocol: A sub-analysis of Ganirelix phase III study of China.
Autorzy :
Li R; IVF Department, Peking University Third Hospital, No. 49 North Garden Road, Haidian district, Beijing, China.
Gong F; IVF Department, Reproductive and Genetic Hospital of Citic-Xiangya, Changsha, Hunan, China.
Chen H; IVF Department, Shanghai JIAI Genetics and IVF Institute, Shanghai, China.
Wang Q; Global Medical Affairs, MSD China, Shanghai, China.
Qiao J; IVF Department, Peking University Third Hospital, No. 49 North Garden Road, Haidian district, Beijing, China. Electronic address: .
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Źródło :
Journal of gynecology obstetrics and human reproduction [J Gynecol Obstet Hum Reprod] 2022 May; Vol. 51 (5), pp. 102363. Date of Electronic Publication: 2022 Mar 19.
Typ publikacji :
Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial
MeSH Terms :
Gonadotropin-Releasing Hormone*/agonists
Hormone Antagonists*/therapeutic use
Estradiol/blood ; Female ; Humans ; Luteinizing Hormone/blood ; Pregnancy ; Progesterone/blood
Czasopismo naukowe
Tytuł :
What is the Role of Thyroid Hormone Receptor Alpha 2 (TRα2) in Human Physiology?
Autorzy :
Paisdzior S; Institute of Experimental Pediatric Endocrinology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Schuelke M; NeuroCure Cluster of Excellence; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Department of Neuropediatrics, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Krude H; Institute of Experimental Pediatric Endocrinology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
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Źródło :
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association [Exp Clin Endocrinol Diabetes] 2022 May; Vol. 130 (5), pp. 296-302. Date of Electronic Publication: 2022 Mar 07.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Alternative Splicing*
Thyroid Hormone Receptors alpha*/genetics
Thyroid Hormone Receptors alpha*/metabolism
Animals ; Humans ; Mice ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; RNA, Messenger/metabolism ; Receptors, Thyroid Hormone/genetics ; Receptors, Thyroid Hormone/metabolism
Czasopismo naukowe
Tytuł :
Corticotropin-releasing factor receptor type 2 in the midbrain critically contributes to the hedonic feeding behavior of mice under heat stress.
Autorzy :
Chen L; Guangdong Provincial Key Laboratory of Animal Nutrition Control, Guangzhou, Guangdong, China; College of Animal Science, South China Agricultural University, China.
Wu H; Guangdong Provincial Key Laboratory of Animal Nutrition Control, Guangzhou, Guangdong, China; College of Animal Science, South China Agricultural University, China.
Li Y; Guangdong Provincial Key Laboratory of Animal Nutrition Control, Guangzhou, Guangdong, China; College of Animal Science, South China Agricultural University, China.
Feng X; Guangdong Provincial Key Laboratory of Animal Nutrition Control, Guangzhou, Guangdong, China; College of Animal Science, South China Agricultural University, China.
Zhu S; Guangdong Provincial Key Laboratory of Animal Nutrition Control, Guangzhou, Guangdong, China; College of Animal Science, South China Agricultural University, China.
Xie K; Guangdong Provincial Key Laboratory of Animal Nutrition Control, Guangzhou, Guangdong, China; College of Animal Science, South China Agricultural University, China.
Wu X; Guangdong Provincial Key Laboratory of Animal Nutrition Control, Guangzhou, Guangdong, China; College of Animal Science, South China Agricultural University, China.
Sun Z; Guangdong Provincial Key Laboratory of Animal Nutrition Control, Guangzhou, Guangdong, China; College of Animal Science, South China Agricultural University, China.
Shu G; Guangdong Provincial Key Laboratory of Animal Nutrition Control, Guangzhou, Guangdong, China; College of Animal Science, South China Agricultural University, China.
Wang S; Guangdong Provincial Key Laboratory of Animal Nutrition Control, Guangzhou, Guangdong, China; College of Animal Science, South China Agricultural University, China.
Gao P; Guangdong Provincial Key Laboratory of Animal Nutrition Control, Guangzhou, Guangdong, China; College of Animal Science, South China Agricultural University, China.
Zhu X; Guangdong Provincial Key Laboratory of Animal Nutrition Control, Guangzhou, Guangdong, China; College of Animal Science, South China Agricultural University, China.
Zhu C; Guangdong Provincial Key Laboratory of Animal Nutrition Control, Guangzhou, Guangdong, China; College of Animal Science, South China Agricultural University, China.
Jiang Q; Guangdong Provincial Key Laboratory of Animal Nutrition Control, Guangzhou, Guangdong, China; College of Animal Science, South China Agricultural University, China.
Wang L; Guangdong Provincial Key Laboratory of Animal Nutrition Control, Guangzhou, Guangdong, China; College of Animal Science, South China Agricultural University, China. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2022 Apr 30; Vol. 602, pp. 77-83. Date of Electronic Publication: 2022 Mar 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Feeding Behavior*
Heat-Shock Response*
Mesencephalon*/metabolism
Receptors, Corticotropin-Releasing Hormone*/genetics
Receptors, Corticotropin-Releasing Hormone*/metabolism
Animals ; Corticotropin-Releasing Hormone/genetics ; Corticotropin-Releasing Hormone/metabolism ; Hypothalamo-Hypophyseal System/metabolism ; Mice ; Pituitary-Adrenal System/metabolism
Czasopismo naukowe
Tytuł :
Association between overweight and growth hormone secretion in patients with non-functioning pituitary tumors.
Autorzy :
Seki Y; Department of Endocrinology and Hypertension, Tokyo Women's Medical University, Tokyo, Japan.
Ichihara A; Department of Endocrinology and Hypertension, Tokyo Women's Medical University, Tokyo, Japan.
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Źródło :
PloS one [PLoS One] 2022 Apr 22; Vol. 17 (4), pp. e0267324. Date of Electronic Publication: 2022 Apr 22 (Print Publication: 2022).
Typ publikacji :
Journal Article
MeSH Terms :
Human Growth Hormone*
Pituitary Neoplasms*/complications
Pituitary Neoplasms*/diagnosis
Pituitary Neoplasms*/surgery
Adult ; Growth Hormone ; Growth Hormone-Releasing Hormone ; Humans ; Overweight/complications ; Retrospective Studies ; Thyroxine
Czasopismo naukowe
Tytuł :
Effective GH Replacement With Once-weekly Somapacitan vs Daily GH in Children with GHD: 3-year Results From REAL 3.
Autorzy :
Sävendahl L; Department of Women's and Children's Health, Karolinska Institutet and Pediatric Endocrinology Unit, Karolinska University Hospital, Solna 171 64, Sweden.
Battelino T; University Medical Center Ljubljana, and Faculty of Medicine, University of Ljubljana, Ljubljana 1000, Slovenia.
Højby Rasmussen M; Novo Nordisk, Clinical Drug Development, Søborg 2860, Denmark.
Brod M; The Brod Group, Mill Valley, CA 94941, USA.
Saenger P; NYU Langone Health, Mineola, NY 11501, USA.
Horikawa R; National Center for Child Health and Development, Tokyo 157-8535, Japan.
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Źródło :
The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2022 Apr 19; Vol. 107 (5), pp. 1357-1367.
Typ publikacji :
Clinical Trial, Phase II; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Dwarfism, Pituitary*/drug therapy
Human Growth Hormone*
Pituitary Hormones, Anterior*
Body Height ; Child ; Growth Hormone/therapeutic use ; Histidine ; Humans ; Insulin-Like Growth Factor I/therapeutic use ; Mannitol ; Phenol
Czasopismo naukowe

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