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    Tytuł:
    Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells.
    Autorzy:
    Ramsuran V; Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA.; KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.
    Naranbhai V; Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA.; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
    Horowitz A; Department of Oncological Sciences, Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
    Qi Y; Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
    Martin MP; Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
    Yuki Y; Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
    Gao X; Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
    Walker-Sperling V; Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA.
    Del Prete GQ; AIDS and Cancer Virus Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
    Schneider DK; AIDS and Cancer Virus Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
    Lifson JD; AIDS and Cancer Virus Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
    Fellay J; School of Life Sciences, École Polytechnique Fédérale de Lausanne, and Swiss Institute of Bioinformatics, Lausanne, Switzerland.
    Deeks SG; Department of Medicine University of California, San Francisco, CA 94143, USA.
    Martin JN; Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94143, USA.
    Goedert JJ; Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20850, USA.
    Wolinsky SM; Division of Infectious Diseases, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
    Michael NL; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
    Kirk GD; Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA.
    Buchbinder S; Department of Medicine University of California, San Francisco, CA 94143, USA.; Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94143, USA.; San Francisco Department of Public Health, HIV Research Section, San Francisco, CA 94102, USA.
    Haas D; Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
    Ndung'u T; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA.; African Health Research Institute, Durban, South Africa.; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.; Max Planck Institute for Infection Biology, Berlin, Germany.
    Goulder P; African Health Research Institute, Durban, South Africa.; Department of Paediatrics, University of Oxford, Oxford, UK.
    Parham P; Departments of Structural Biology and Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.
    Walker BD; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA.; African Health Research Institute, Durban, South Africa.; Institute for Medical and Engineering Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
    Carlson JM; Microsoft Research, Redmond, WA 98052, USA.
    Carrington M; Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA. .; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA.
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    Źródło:
    Science (New York, N.Y.) [Science] 2018 Jan 05; Vol. 359 (6371), pp. 86-90. Date of Electronic Publication: 2018 Jan 04.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    HIV/*immunology
    HIV Infections/*immunology
    HLA Antigens/*metabolism
    Killer Cells, Natural/*immunology
    NK Cell Lectin-Like Receptor Subfamily C/*metabolism
    Alleles ; CD4 Lymphocyte Count ; Cohort Studies ; HIV Infections/drug therapy ; HIV Infections/genetics ; HLA Antigens/genetics ; Humans ; Ligands ; NK Cell Lectin-Like Receptor Subfamily C/antagonists & inhibitors ; NK Cell Lectin-Like Receptor Subfamily C/genetics ; Protein Sorting Signals ; Viremia/immunology
    Czasopismo naukowe
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