Autor: "Hou G" - OpacWWW - Prolib Integro

Skocz do pozycji: 1.

Tytuł:: Hydroxyl-substituted double Schiff-base condensed 4-piperidone/cyclohexanones as potential anticancer agents with biological evaluation.
Autorzy:: Zhang L; a School of Basic Medical Sciences, Binzhou Medical University , Yantai , P. R. China.
Chen Q; b Department of Pharmacy , Taihe County People's Hospital , Taihe , P. R. China.
Hou G; a School of Basic Medical Sciences, Binzhou Medical University , Yantai , P. R. China.
Zhao W; a School of Basic Medical Sciences, Binzhou Medical University , Yantai , P. R. China.
Hou Y; a School of Basic Medical Sciences, Binzhou Medical University , Yantai , P. R. China.; Pokaż więcej
Źródło:: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2019 Dec; Vol. 34 (1), pp. 264-271.
Typ publikacji:: Journal Article
MeSH Terms:: Antineoplastic Agents/*pharmacology
Cyclohexanones/*pharmacology
Hydroxides/*chemistry
Piperidones/*pharmacology
Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cyclohexanones/chemistry ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Female ; Humans ; Liver Neoplasms, Experimental/drug therapy ; Liver Neoplasms, Experimental/pathology ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Molecular Docking Simulation ; Molecular Structure ; Piperidones/chemistry ; Schiff Bases/chemistry ; Structure-Activity Relationship

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Skocz do pozycji: 2.

Tytuł:: Novel asymmetric 3,5-bis(arylidene)piperidin-4-one derivatives: synthesis, crystal structures and cytotoxicity.
Autorzy:: Yao B; School of Pharmacy, The Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of China, Binzhou Medical University, Yantai 264003, People's Republic of China.
Li N; School of Pharmacy, The Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of China, Binzhou Medical University, Yantai 264003, People's Republic of China.
Wang C; School of Pharmacy, The Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of China, Binzhou Medical University, Yantai 264003, People's Republic of China.
Hou G; School of Pharmacy, The Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of China, Binzhou Medical University, Yantai 264003, People's Republic of China.
Meng Q; School of Pharmacy, Yantai University, Yantai 264005, People's Republic of China.
Yan K; School of Pharmacy, The Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of China, Binzhou Medical University, Yantai 264003, People's Republic of China.; Pokaż więcej
Źródło:: Acta crystallographica. Section C, Structural chemistry [Acta Crystallogr C Struct Chem] 2018 Jun 01; Vol. 74 (Pt 6), pp. 659-665. Date of Electronic Publication: 2018 May 08.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Antineoplastic Agents/*chemistry
Antineoplastic Agents/*pharmacology
Piperidines/*chemistry
Piperidines/*pharmacology
Crystallography, X-Ray ; Humans ; Hydrogen Bonding ; Molecular Structure ; Spectroscopy, Fourier Transform Infrared

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Skocz do pozycji: 3.

Tytuł:: Synthesis, antitumor activity evaluation of some new N-aroyl-α,β-unsaturated piperidones with fluorescence.
Autorzy:: Sun J; a 1 School of Pharmacy, Binzhou Medical University , Yantai , Shandong , P.R. China and.
Wang S; b 2 Yantai Yuhuangding Hospital Emergency , Yantai , Shandong , P.R. China.
Li H; a 1 School of Pharmacy, Binzhou Medical University , Yantai , Shandong , P.R. China and.
Jiang W; a 1 School of Pharmacy, Binzhou Medical University , Yantai , Shandong , P.R. China and.
Hou G; a 1 School of Pharmacy, Binzhou Medical University , Yantai , Shandong , P.R. China and.
Zhao F; a 1 School of Pharmacy, Binzhou Medical University , Yantai , Shandong , P.R. China and.
Cong W; a 1 School of Pharmacy, Binzhou Medical University , Yantai , Shandong , P.R. China and.; Pokaż więcej
Źródło:: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2016; Vol. 31 (3), pp. 495-502. Date of Electronic Publication: 2015 Sep 18.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Fluorescence*
Antineoplastic Agents/*chemical synthesis
Antineoplastic Agents/*pharmacology
Piperidones/*pharmacology
Animals ; Antineoplastic Agents/chemistry ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Mice ; Mice, Nude ; Molecular Structure ; Neoplasms, Experimental/drug therapy ; Neoplasms, Experimental/pathology ; Piperidones/chemical synthesis ; Piperidones/chemistry ; Structure-Activity Relationship

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Skocz do pozycji: 4.

Tytuł:: The Antitumor Activity of the Novel Compound Jesridonin on Human Esophageal Carcinoma Cells.
Autorzy:: Wang C; School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, 450001, China; New Drug Research & Development Center, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, 450001, China.
Jiang L; School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, 450001, China; New Drug Research & Development Center, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, 450001, China.
Wang S; School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, 450001, China; New Drug Research & Development Center, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, 450001, China.
Shi H; School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, 450001, China; New Drug Research & Development Center, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, 450001, China.
Wang J; School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, 450001, China; New Drug Research & Development Center, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, 450001, China.
Wang R; School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, 450001, China; New Drug Research & Development Center, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, 450001, China.
Li Y; School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, 450001, China; New Drug Research & Development Center, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, 450001, China.
Dou Y; School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, 450001, China; New Drug Research & Development Center, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, 450001, China.
Liu Y; School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, 450001, China; New Drug Research & Development Center, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, 450001, China.
Hou G; School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, 450001, China; New Drug Research & Development Center, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, 450001, China.
Ke Y; School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, 450001, China; New Drug Research & Development Center, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, 450001, China.
Liu H; School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, 450001, China; New Drug Research & Development Center, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, 450001, China.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2015 Jun 23; Vol. 10 (6), pp. e0130284. Date of Electronic Publication: 2015 Jun 23 (Print Publication: 2015).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Antineoplastic Agents/*pharmacology
Diterpenes, Kaurane/*pharmacology
Esophageal Neoplasms/*pathology
Animals ; Cell Line, Tumor ; Esophageal Neoplasms/metabolism ; Humans ; Mice ; Neoplasm Proteins/metabolism ; Xenograft Model Antitumor Assays

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Skocz do pozycji: 5.

Tytuł:: Antitumor effect and mechanism of action of a tumor-targeting recombinant human tumor necrosis factor-α fusion protein mediated by urokinase.
Autorzy:: Dai YC; Institute of Medical Inspection, Guangdong Medical College, Zhanjiang, Guangdong 523808, P.R. China.
Yang SM; Institute of Medical Inspection, Guangdong Medical College, Zhanjiang, Guangdong 523808, P.R. China.
Wang X; Institute of Medical Inspection, Guangdong Medical College, Zhanjiang, Guangdong 523808, P.R. China.
Zhou YJ; Department of Clinical Biochemistry, Guangdong Medical College, Zhanjiang, Guangdong 523808, P.R. China.
Hou G; Department of Clinical Biochemistry, Guangdong Medical College, Zhanjiang, Guangdong 523808, P.R. China.
Huang DN; Department of Clinical Biochemistry, Guangdong Medical College, Zhanjiang, Guangdong 523808, P.R. China.; Pokaż więcej
Źródło:: Molecular medicine reports [Mol Med Rep] 2015 Jun; Vol. 11 (6), pp. 4333-40. Date of Electronic Publication: 2015 Feb 06.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Antineoplastic Agents/*pharmacology
Recombinant Fusion Proteins/*pharmacology
Tumor Necrosis Factor-alpha/*pharmacology
Urokinase-Type Plasminogen Activator/*metabolism
Animals ; Apoptosis/drug effects ; Cell Line, Tumor ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Female ; Gene Expression ; Humans ; Immunohistochemistry ; Kidney/drug effects ; Kidney/metabolism ; Liver/drug effects ; Liver/metabolism ; Male ; Mice ; Mutation ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/metabolism ; Neoplasms/pathology ; Proto-Oncogene Proteins c-bcl-2/genetics ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Recombinant Fusion Proteins/genetics ; Tumor Burden/drug effects ; Tumor Necrosis Factor-alpha/genetics ; Urokinase-Type Plasminogen Activator/blood ; Vascular Endothelial Growth Factor A/genetics ; Vascular Endothelial Growth Factor A/metabolism ; bcl-2-Associated X Protein/genetics ; bcl-2-Associated X Protein/metabolism

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Skocz do pozycji: 6.

Tytuł:: Design, synthesis and bioevaluation of novel N-substituted-3,5-bis(arylidene)-4-piperidone derivatives as cytotoxic and antitumor agents with fluorescent properties.
Autorzy:: Sun J; Binzhou Medical University, Yantai, 264003, China.
Zhang S
Yu C
Hou G
Zhang X
Li K
Zhao F; Pokaż więcej
Źródło:: Chemical biology & drug design [Chem Biol Drug Des] 2014 Apr; Vol. 83 (4), pp. 392-400. Date of Electronic Publication: 2014 Feb 01.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Drug Design*
Antineoplastic Agents/*chemical synthesis
Antineoplastic Agents/*pharmacology
Fluorescent Dyes/*chemical synthesis
Piperidones/*chemical synthesis
Piperidones/*pharmacology
Antineoplastic Agents/chemistry ; Cell Line, Tumor ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Fluorescent Dyes/chemistry ; Fluorescent Dyes/pharmacology ; Humans ; Molecular Structure ; Piperidones/chemistry

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