Autor: "Howell BA" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: The Combination of a Human Biomimetic Liver Microphysiology System with BIOLOGXsym, a Quantitative Systems Toxicology (QST) Modeling Platform for Macromolecules, Provides Mechanistic Understanding of Tocilizumab- and GGF2-Induced Liver Injury.
Autorzy:: Beaudoin JJ; DILIsym Services Division, Simulations Plus Inc., Research Triangle Park, Durham, NC 27709, USA.
Clemens L; DILIsym Services Division, Simulations Plus Inc., Research Triangle Park, Durham, NC 27709, USA.
Miedel MT; Department of Computational and Systems Biology, Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15219, USA.
Gough A; Department of Computational and Systems Biology, Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15219, USA.
Zaidi F; Metabolon Inc., Durham, NC 27713, USA.
Ramamoorthy P; Metabolon Inc., Durham, NC 27713, USA.
Wong KE; Metabolon Inc., Durham, NC 27713, USA.
Sarangarajan R; Metabolon Inc., Durham, NC 27713, USA.
Battista C; DILIsym Services Division, Simulations Plus Inc., Research Triangle Park, Durham, NC 27709, USA.
Shoda LKM; DILIsym Services Division, Simulations Plus Inc., Research Triangle Park, Durham, NC 27709, USA.
Siler SQ; DILIsym Services Division, Simulations Plus Inc., Research Triangle Park, Durham, NC 27709, USA.
Taylor DL; Department of Computational and Systems Biology, Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15219, USA.
Howell BA; DILIsym Services Division, Simulations Plus Inc., Research Triangle Park, Durham, NC 27709, USA.
Vernetti LA; Department of Computational and Systems Biology, Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15219, USA.
Yang K; DILIsym Services Division, Simulations Plus Inc., Research Triangle Park, Durham, NC 27709, USA.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Jun 02; Vol. 24 (11). Date of Electronic Publication: 2023 Jun 02.
Typ publikacji:: Journal Article
MeSH Terms:: Biological Products*/pharmacology
Chemical and Drug Induced Liver Injury*/etiology
Chemical and Drug Induced Liver Injury, Chronic*
Humans ; Biomimetics ; Liver

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Skocz do pozycji: 2.

Tytuł:: Quantitative systems toxicology (QST) reproduces species differences in PF-04895162 liver safety due to combined mitochondrial and bile acid toxicity.
Autorzy:: Generaux G; DILIsym Services Inc. Research Triangle Park North Carolina.
Lakhani VV; DILIsym Services Inc. Research Triangle Park North Carolina.
Yang Y; DILIsym Services Inc. Research Triangle Park North Carolina.; Present address: Division of Pharmacometrics Office of Clinical Pharmacology Office of Translational Sciences Center for Drug Evaluation and Research Food and Drug Administration Food and Drug Administration Silver Spring Maryland.
Nadanaciva S; Compound Safety Prediction Worldwide Medicinal Chemistry Pfizer Inc. Groton Connecticut.
Qiu L; Investigative Toxicology Drug Safety Research and Development Pfizer Inc. Groton Connecticut.
Riccardi K; Pharmacokinetics, Dynamics and Metabolism Medicinal Sciences Pfizer Inc. Groton Connecticut.
Di L; Pharmacokinetics, Dynamics and Metabolism Medicinal Sciences Pfizer Inc. Groton Connecticut.
Howell BA; DILIsym Services Inc. Research Triangle Park North Carolina.
Siler SQ; DILIsym Services Inc. Research Triangle Park North Carolina.
Watkins PB; UNC Eshelman School of Pharmacy University of North Carolina at Chapel Hill Chapel Hill North Carolina.; UNC Institute for Drug Safety Sciences University of North Carolina at Chapel Hill Chapel Hill North Carolina.
Barton HA; Translational Modeling and Simulation Biomedicine Design Pfizer, Inc. Groton Connecticut.
Aleo MD; Investigative Toxicology Drug Safety Research and Development Pfizer Inc. Groton Connecticut.
Shoda LKM; DILIsym Services Inc. Research Triangle Park North Carolina.; Pokaż więcej
Źródło:: Pharmacology research & perspectives [Pharmacol Res Perspect] 2019 Oct 09; Vol. 7 (6), pp. e00523. Date of Electronic Publication: 2019 Oct 09 (Print Publication: 2019).
Typ publikacji:: Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:: Models, Biological*
ATP Binding Cassette Transporter, Subfamily B, Member 11/*antagonists & inhibitors
Anticonvulsants/*toxicity
Chemical and Drug Induced Liver Injury/*pathology
Quinazolines/*toxicity
ATP Binding Cassette Transporter, Subfamily B, Member 11/metabolism ; Administration, Oral ; Adolescent ; Adult ; Animals ; Anticonvulsants/administration & dosage ; Chemical and Drug Induced Liver Injury/etiology ; Computer Simulation ; Dose-Response Relationship, Drug ; Drug Evaluation, Preclinical/standards ; Epilepsy/drug therapy ; HEK293 Cells ; Healthy Volunteers ; Hepatocytes ; Humans ; Inhibitory Concentration 50 ; Liver/drug effects ; Liver/pathology ; Male ; Middle Aged ; Mitochondria/drug effects ; Quinazolines/administration & dosage ; Rats ; Species Specificity ; Taurocholic Acid/metabolism ; Young Adult

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