Autor: "Huang W" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Tumor-secreted IFI35 promotes proliferation and cytotoxic activity of CD8 T cells through PI3K/AKT/mTOR signaling pathway in colorectal cancer.
Autorzy:: Li P; Guangdong Institute of Gastroenterology; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, People's Republic of China.; School of Medicine, Sun Yat-Sen University, Shenzhen, Guangdong, People's Republic of China.; Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.
Zhou D; Department of Hepatobiliary and Pancreatic Surgery, Sun Yat-Sen University Cancer Center, Guangdong, Guangzhou, People's Republic of China.
Chen D; Guangdong Institute of Gastroenterology; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, People's Republic of China.
Cheng Y; Department of Radiation Oncology, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, People's Republic of China.
Chen Y; School of Medicine, Sun Yat-Sen University, Shenzhen, Guangdong, People's Republic of China.
Lin Z; Guangdong Institute of Gastroenterology; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, People's Republic of China.
Zhang X; Guangzhou Biosyngen Co., Ltd., Guangdong, People's Republic of China.
Huang Z; Guangzhou Biosyngen Co., Ltd., Guangdong, People's Republic of China.
Cai J; Department of General Surgery (Department of Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangdong, Guangzhou, People's Republic of China.
Huang W; Guangdong Institute of Gastroenterology; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, People's Republic of China.
Lin Y; Guangdong Institute of Gastroenterology; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, People's Republic of China.
Ke H; Guangdong Institute of Gastroenterology; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, People's Republic of China.
Long J; Guangdong Institute of Gastroenterology; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, People's Republic of China.
Zou Y; Guangdong Institute of Gastroenterology; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, People's Republic of China. .; Department of General Surgery (Department of Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangdong, Guangzhou, People's Republic of China. .
Ye S; Guangdong Institute of Gastroenterology; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, People's Republic of China. .; Department of General Surgery (Department of Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangdong, Guangzhou, People's Republic of China. .; Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China. .
Lan P; Guangdong Institute of Gastroenterology; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, People's Republic of China. .; Department of General Surgery (Department of Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangdong, Guangzhou, People's Republic of China. .; Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China. .; State Key Laboratory of Oncology in South China, Sun Yat-sen University, Guangzhou, People's Republic of China. .; Pokaż więcej
Źródło:: Journal of biomedical science [J Biomed Sci] 2023 Jun 28; Vol. 30 (1), pp. 47. Date of Electronic Publication: 2023 Jun 28.
Typ publikacji:: Journal Article
MeSH Terms:: Antineoplastic Agents*
Colonic Neoplasms*
Humans ; Animals ; Mice ; Phosphatidylinositol 3-Kinases ; Proto-Oncogene Proteins c-akt/genetics ; CD8-Positive T-Lymphocytes ; Proteomics ; Signal Transduction ; TOR Serine-Threonine Kinases/genetics ; Tumor Microenvironment

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Skocz do pozycji: 2.

Tytuł:: Altered resting-state hippocampal functional connectivity in breast cancer survivors with chemotherapy-induced amenorrhea.
Autorzy:: Zhuang Y; Department of Medical Imaging, Medical Imaging Center, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, China.
Guo L; Department of Medical Imaging, Medical Imaging Center, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, China.
Huang W; Department of Medical Imaging, Medical Imaging Center, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, China.
Bo G; Department of Medical Imaging, Medical Imaging Center, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, China.
Zhang J; Department of Medical Imaging, Medical Imaging Center, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, China.
Zhu Z; Department of Medical Imaging, Medical Imaging Center, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, China.
Feng Y; Department of Medical Imaging, Medical Imaging Center, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, China.; Pokaż więcej
Źródło:: Brain and behavior [Brain Behav] 2023 Jun; Vol. 13 (6), pp. e3039. Date of Electronic Publication: 2023 May 08.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Breast Neoplasms*/drug therapy
Breast Neoplasms*/psychology
Cancer Survivors*
Antineoplastic Agents*/adverse effects
Female ; Humans ; Amenorrhea/chemically induced ; Amenorrhea/diagnostic imaging ; Amenorrhea/drug therapy ; Brain ; Magnetic Resonance Imaging/methods ; Hippocampus/diagnostic imaging ; Hormones/therapeutic use

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Skocz do pozycji: 3.

Tytuł:: A Pyrazolate Osmium(VI) Nitride Exhibits Anticancer Activity through Modulating Protein Homeostasis in HepG2 Cells.
Autorzy:: Huang C; Department of Physiology, Shantou University Medical College, Shantou 515041, China.; Department of Biological Chemistry, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA.
Huang W; Department of Medicinal Chemistry, Shantou University Medical College, Shantou 515041, China.
Ji P; Department of Medicinal Chemistry, Shantou University Medical College, Shantou 515041, China.
Song F; Department of Medicinal Chemistry, Shantou University Medical College, Shantou 515041, China.
Liu T; Department of Medicinal Chemistry, Shantou University Medical College, Shantou 515041, China.
Li M; Department of Physiology, Shantou University Medical College, Shantou 515041, China.
Guo H; Department of Physiology, Shantou University Medical College, Shantou 515041, China.
Huang Y; Department of Medicinal Chemistry, Shantou University Medical College, Shantou 515041, China.
Yu C; Department of Physiology, Shantou University Medical College, Shantou 515041, China.
Wang C; Department of Medicinal Chemistry, Shantou University Medical College, Shantou 515041, China.
Ni W; Department of Medicinal Chemistry, Shantou University Medical College, Shantou 515041, China.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2022 Oct 24; Vol. 23 (21). Date of Electronic Publication: 2022 Oct 24.
Typ publikacji:: Journal Article
MeSH Terms:: Osmium*/pharmacology
Antineoplastic Agents*/pharmacology
Humans ; Hep G2 Cells ; Proteostasis ; Apoptosis ; Cell Line, Tumor

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Skocz do pozycji: 4.

Tytuł:: Mechanism of Citri Reticulatae Pericarpium as an Anticancer Agent from the Perspective of Flavonoids: A Review.
Autorzy:: Song L; College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610000, China.
Xiong P; College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610000, China.
Zhang W; College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610000, China.
Hu H; College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610000, China.
Tang S; College of Traditional Chinese Medicine, Hainan Medical University, Haikou 571199, China.
Jia B; College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610000, China.
Huang W; College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610000, China.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2022 Aug 31; Vol. 27 (17). Date of Electronic Publication: 2022 Aug 31.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/therapeutic use
Citrus*
Drugs, Chinese Herbal*/pharmacology
Drugs, Chinese Herbal*/therapeutic use
Flavonoids/pharmacology ; Flavonoids/therapeutic use ; Medicine, Chinese Traditional

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Skocz do pozycji: 5.

Tytuł:: Exploring the kinase-inhibitor fragment interaction space facilitates the discovery of kinase inhibitor overcoming resistance by mutations.
Autorzy:: Wang ZZ; Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan, 430079, P. R. China.
Wang MS; Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan, 430079, P. R. China.
Wang F; Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan, 430079, P. R. China.
Shi XX; Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan, 430079, P. R. China.
Huang W; Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan, 430079, P. R. China.
Hao GF; Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan, 430079, P. R. China.
Yang GF; Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan, 430079, P. R. China.; Pokaż więcej
Źródło:: Briefings in bioinformatics [Brief Bioinform] 2022 Jul 18; Vol. 23 (4).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Antineoplastic Agents*/therapeutic use
Neoplasms*/genetics
Humans ; Mutation ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Receptor, trkA/genetics ; Receptor, trkA/metabolism

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Skocz do pozycji: 6.

Tytuł:: DTX-P7, a peptide-drug conjugate, is highly effective for non-small cell lung cancer.
Autorzy:: Jiang Y; Department of Pharmacology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing, 100005, China.
Huang W; Department of Pharmacology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing, 100005, China.
Sun X; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
Yang X; Department of Pharmacology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing, 100005, China.
Wu Y; Department of Pharmacology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing, 100005, China.
Shi J; Department of Pharmacology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing, 100005, China.
Zheng J; Department of Pharmacology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing, 100005, China.
Fan S; Department of Pharmacology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing, 100005, China.
Liu J; Department of Pharmacology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing, 100005, China.
Wang J; Department of Pharmacology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing, 100005, China.
Liang Z; Department of Pharmacology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing, 100005, China.
Yang N; Department of Pharmacology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing, 100005, China. .
Liu Z; Department of Pharmacology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing, 100005, China. .
Liu Y; Department of Pharmacology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing, 100005, China. .; Pokaż więcej
Źródło:: Journal of hematology & oncology [J Hematol Oncol] 2022 Jun 03; Vol. 15 (1), pp. 73. Date of Electronic Publication: 2022 Jun 03.
Typ publikacji:: Letter; Research Support, Non-U.S. Gov't
MeSH Terms:: Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/therapeutic use
Carcinoma, Non-Small-Cell Lung*/drug therapy
Carcinoma, Non-Small-Cell Lung*/pathology
Lung Neoplasms*/drug therapy
Lung Neoplasms*/pathology
Cell Line, Tumor ; Docetaxel/chemistry ; Docetaxel/pharmacology ; Drug Carriers/chemistry ; Humans ; Peptides/chemistry ; Peptides/pharmacology ; Peptides/therapeutic use

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Skocz do pozycji: 7.

Tytuł:: Design, Synthesis, and Cytotoxic Activity of Novel Natural Arylsulfonamide-Inspired Molecules.
Autorzy:: Huang W; Key Laboratory of Microbial Pesticides, Ministry of Agriculture and Rural Affairs, Wuhan 430064, China.; National Biopesticide Engineering Research Centre, Hubei Biopesticide Engineering Research Centre, Hubei Academy of Agricultural Sciences, Wuhan 430064, China.
Shi L; Key Laboratory of Microbial Pesticides, Ministry of Agriculture and Rural Affairs, Wuhan 430064, China.; National Biopesticide Engineering Research Centre, Hubei Biopesticide Engineering Research Centre, Hubei Academy of Agricultural Sciences, Wuhan 430064, China.
Liu M; Key Laboratory of Microbial Pesticides, Ministry of Agriculture and Rural Affairs, Wuhan 430064, China.; National Biopesticide Engineering Research Centre, Hubei Biopesticide Engineering Research Centre, Hubei Academy of Agricultural Sciences, Wuhan 430064, China.
Zhang Z; Key Laboratory of Microbial Pesticides, Ministry of Agriculture and Rural Affairs, Wuhan 430064, China.; National Biopesticide Engineering Research Centre, Hubei Biopesticide Engineering Research Centre, Hubei Academy of Agricultural Sciences, Wuhan 430064, China.
Liu F; Key Laboratory of Microbial Pesticides, Ministry of Agriculture and Rural Affairs, Wuhan 430064, China.; National Biopesticide Engineering Research Centre, Hubei Biopesticide Engineering Research Centre, Hubei Academy of Agricultural Sciences, Wuhan 430064, China.
Long T; Key Laboratory of Microbial Pesticides, Ministry of Agriculture and Rural Affairs, Wuhan 430064, China.; National Biopesticide Engineering Research Centre, Hubei Biopesticide Engineering Research Centre, Hubei Academy of Agricultural Sciences, Wuhan 430064, China.
Wen S; Key Laboratory of Microbial Pesticides, Ministry of Agriculture and Rural Affairs, Wuhan 430064, China.; National Biopesticide Engineering Research Centre, Hubei Biopesticide Engineering Research Centre, Hubei Academy of Agricultural Sciences, Wuhan 430064, China.
Huang D; Key Laboratory of Microbial Pesticides, Ministry of Agriculture and Rural Affairs, Wuhan 430064, China.; National Biopesticide Engineering Research Centre, Hubei Biopesticide Engineering Research Centre, Hubei Academy of Agricultural Sciences, Wuhan 430064, China.
Wang K; Key Laboratory of Microbial Pesticides, Ministry of Agriculture and Rural Affairs, Wuhan 430064, China.; National Biopesticide Engineering Research Centre, Hubei Biopesticide Engineering Research Centre, Hubei Academy of Agricultural Sciences, Wuhan 430064, China.
Zhou R; Key Laboratory of Microbial Pesticides, Ministry of Agriculture and Rural Affairs, Wuhan 430064, China.; National Biopesticide Engineering Research Centre, Hubei Biopesticide Engineering Research Centre, Hubei Academy of Agricultural Sciences, Wuhan 430064, China.
Fang W; Key Laboratory of Microbial Pesticides, Ministry of Agriculture and Rural Affairs, Wuhan 430064, China.; National Biopesticide Engineering Research Centre, Hubei Biopesticide Engineering Research Centre, Hubei Academy of Agricultural Sciences, Wuhan 430064, China.
Hu H; Key Laboratory of Microbial Pesticides, Ministry of Agriculture and Rural Affairs, Wuhan 430064, China.; National Biopesticide Engineering Research Centre, Hubei Biopesticide Engineering Research Centre, Hubei Academy of Agricultural Sciences, Wuhan 430064, China.
Ke S; Key Laboratory of Microbial Pesticides, Ministry of Agriculture and Rural Affairs, Wuhan 430064, China.; National Biopesticide Engineering Research Centre, Hubei Biopesticide Engineering Research Centre, Hubei Academy of Agricultural Sciences, Wuhan 430064, China.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2022 Feb 22; Vol. 27 (5). Date of Electronic Publication: 2022 Feb 22.
Typ publikacji:: Journal Article
MeSH Terms:: Antineoplastic Agents*

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Skocz do pozycji: 8.

Tytuł:: Novel brain-targeted nanomicelles for anti-glioma therapy mediated by the ApoE-enriched protein corona in vivo.
Autorzy:: Zhang ZA; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China.; Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Xin X; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China.; Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Liu C; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China.; Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Liu YH; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China.; Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Duan HX; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China.; Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Qi LL; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China.; Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Zhang YY; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China.; Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Zhao HM; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China.; Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Chen LQ; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China.; Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Jin MJ; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China.; Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Gao ZG; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China. .; Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China. .
Huang W; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China. .; Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China. .; Pokaż więcej
Źródło:: Journal of nanobiotechnology [J Nanobiotechnology] 2021 Dec 28; Vol. 19 (1), pp. 453. Date of Electronic Publication: 2021 Dec 28.
Typ publikacji:: Journal Article
MeSH Terms:: Protein Corona*/chemistry
Antineoplastic Agents/*administration & dosage
Apolipoproteins E/*administration & dosage
Brain/*drug effects
Glioma/*drug therapy
Nanoparticles/*administration & dosage
Amyloid beta-Peptides/administration & dosage ; Amyloid beta-Peptides/chemistry ; Amyloid beta-Peptides/pharmacokinetics ; Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacokinetics ; Apolipoproteins E/chemistry ; Apolipoproteins E/pharmacokinetics ; Blood-Brain Barrier/metabolism ; Brain/metabolism ; Cell Line ; Cell Survival/drug effects ; Drug Delivery Systems ; Glioma/metabolism ; Humans ; Mice ; Micelles ; Nanoparticles/chemistry ; Paclitaxel/administration & dosage ; Paclitaxel/chemistry ; Paclitaxel/pharmacokinetics ; Peptide Fragments/administration & dosage ; Peptide Fragments/chemistry ; Peptide Fragments/pharmacokinetics ; Polyesters/administration & dosage ; Polyesters/chemistry ; Polyesters/pharmacokinetics ; Polyethylene Glycols/administration & dosage ; Polyethylene Glycols/chemistry ; Polyethylene Glycols/pharmacokinetics

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Skocz do pozycji: 9.

Tytuł:: Optical Fibre-Enabled Photoswitching for Localised Activation of an Anti-Cancer Therapeutic Drug.
Autorzy:: Palasis KA; Department of Chemistry, The University of Adelaide, Adelaide 5005, Australia.; Institute for Photonics and Advanced Sensing, The University of Adelaide, Adelaide 5005, Australia.; The Australian Research Council Centre of Excellence for Nanoscale Biophotonics, The University of Adelaide, Adelaide 5005, Australia.
Lokman NA; Robinson Research Institute, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide 5005, Australia.
Quirk BC; Institute for Photonics and Advanced Sensing, The University of Adelaide, Adelaide 5005, Australia.; The Australian Research Council Centre of Excellence for Nanoscale Biophotonics, The University of Adelaide, Adelaide 5005, Australia.; School of Biomedicine, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide 5005, Australia.
Adwal A; Robinson Research Institute, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide 5005, Australia.
Scolaro L; Institute for Photonics and Advanced Sensing, The University of Adelaide, Adelaide 5005, Australia.; The Australian Research Council Centre of Excellence for Nanoscale Biophotonics, The University of Adelaide, Adelaide 5005, Australia.; School of Biomedicine, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide 5005, Australia.
Huang W; Institute for Photonics and Advanced Sensing, The University of Adelaide, Adelaide 5005, Australia.; The Australian Research Council Centre of Excellence for Nanoscale Biophotonics, The University of Adelaide, Adelaide 5005, Australia.; Centre of Research Excellence in Translating Nutritional Science to Good Health, Adelaide Medical School, The University of Adelaide, Adelaide 5005, Australia.
Ricciardelli C; Robinson Research Institute, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide 5005, Australia.
Oehler MK; Robinson Research Institute, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide 5005, Australia.; Department of Gynaecological Oncology, Royal Adelaide Hospital, Adelaide 5000, Australia.; Future Industries Institute, University of South Australia, Adelaide 5095, Australia.
McLaughlin RA; Institute for Photonics and Advanced Sensing, The University of Adelaide, Adelaide 5005, Australia.; The Australian Research Council Centre of Excellence for Nanoscale Biophotonics, The University of Adelaide, Adelaide 5005, Australia.; School of Biomedicine, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide 5005, Australia.
Abell AD; Department of Chemistry, The University of Adelaide, Adelaide 5005, Australia.; Institute for Photonics and Advanced Sensing, The University of Adelaide, Adelaide 5005, Australia.; The Australian Research Council Centre of Excellence for Nanoscale Biophotonics, The University of Adelaide, Adelaide 5005, Australia.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Oct 07; Vol. 22 (19). Date of Electronic Publication: 2021 Oct 07.
Typ publikacji:: Journal Article
MeSH Terms:: Antineoplastic Agents/*pharmacology
Colorectal Neoplasms/*drug therapy
Dimethyl Sulfoxide/*chemistry
Optical Fibers/*statistics & numerical data
Antineoplastic Agents/chemistry ; Cell Survival ; Humans ; Tumor Cells, Cultured

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Skocz do pozycji: 10.

Tytuł:: Design, synthesis, and biological evaluation of novel 4,4-difluoro-1-methyl-N, 6-diphenyl-5, 6-dihydro-4H-pyrimido [4, 5-b] [1, 2, 4] triazolo [4, 3-d] [1, 4] diazepin-8-amine derivatives as potential BRD4 inhibitors.
Autorzy:: Li J; Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.
Zhang W; Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.; Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, China Pharmaceutical University, Nanjing, China.
Qiu Q; Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.
Zhou D; Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.
Feng Z; Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.
Tong Z; Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.
Wei J; Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.
Huang W; Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.; Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, China Pharmaceutical University, Nanjing, China.
Li J; Henan University of Chinese Medicine, Zhengzhou, China.
Qian H; Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.; Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, China Pharmaceutical University, Nanjing, China.
Shi W; Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.; Pokaż więcej
Źródło:: Chemical biology & drug design [Chem Biol Drug Des] 2021 May; Vol. 97 (5), pp. 1117-1128. Date of Electronic Publication: 2021 Mar 06.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Drug Design*
Antineoplastic Agents/*chemical synthesis
Cell Cycle Proteins/*antagonists & inhibitors
Transcription Factors/*antagonists & inhibitors
Triazoles/*chemistry
Amines/chemistry ; Antineoplastic Agents/metabolism ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Binding Sites ; Cell Cycle Proteins/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Down-Regulation/drug effects ; G1 Phase Cell Cycle Checkpoints/drug effects ; Humans ; Molecular Docking Simulation ; Proto-Oncogene Proteins c-myc/metabolism ; Structure-Activity Relationship ; Transcription Factors/metabolism ; Triazoles/metabolism ; Triazoles/pharmacology

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Skocz do pozycji: 11.

Tytuł:: Identification of probe-quality degraders for Poly(ADP-ribose) polymerase-1 (PARP-1).
Autorzy:: Zhang Z; Key Laboratory of Neuropsychiatric Drug Research of Zhejiang Province, Hangzhou Medical College, Hangzhou, P. R. China.
Chang X; Key Laboratory of Neuropsychiatric Drug Research of Zhejiang Province, Hangzhou Medical College, Hangzhou, P. R. China.
Zhang C; Key Laboratory of Neuropsychiatric Drug Research of Zhejiang Province, Hangzhou Medical College, Hangzhou, P. R. China.
Zeng S; Key Laboratory of Neuropsychiatric Drug Research of Zhejiang Province, Hangzhou Medical College, Hangzhou, P. R. China.
Liang M; Key Laboratory of Neuropsychiatric Drug Research of Zhejiang Province, Hangzhou Medical College, Hangzhou, P. R. China.
Ma Z; Key Laboratory of Neuropsychiatric Drug Research of Zhejiang Province, Hangzhou Medical College, Hangzhou, P. R. China.
Wang Z; Key Laboratory of Neuropsychiatric Drug Research of Zhejiang Province, Hangzhou Medical College, Hangzhou, P. R. China.
Huang W; Key Laboratory of Neuropsychiatric Drug Research of Zhejiang Province, Hangzhou Medical College, Hangzhou, P. R. China.
Shen Z; Key Laboratory of Neuropsychiatric Drug Research of Zhejiang Province, Hangzhou Medical College, Hangzhou, P. R. China.; Pokaż więcej
Źródło:: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 1606-1615.
Typ publikacji:: Journal Article
MeSH Terms:: Antineoplastic Agents/*pharmacology
Poly (ADP-Ribose) Polymerase-1/*antagonists & inhibitors
Poly(ADP-ribose) Polymerase Inhibitors/*pharmacology
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; Cell Cycle Checkpoints/drug effects ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Lenalidomide ; Molecular Structure ; Phthalazines ; Piperazines ; Poly (ADP-Ribose) Polymerase-1/metabolism ; Poly(ADP-ribose) Polymerase Inhibitors/chemical synthesis ; Poly(ADP-ribose) Polymerase Inhibitors/chemistry ; Proteolysis/drug effects ; Structure-Activity Relationship

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Skocz do pozycji: 12.

Tytuł:: Grignard Reagent Utilization Enables a Practical and Scalable Construction of 3-Substituted 5-Chloro-1,6-naphthyridin-4-one Derivatives.
Autorzy:: Wang MS; Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan 430079, China.
Gong Y; Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan 430079, China.
Yu ZC; Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan 430079, China.
Tian YG; Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan 430079, China.
Zhuo LS; Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan 430079, China.
Huang W; Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan 430079, China.
She NF; Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan 430079, China.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2020 Dec 01; Vol. 25 (23). Date of Electronic Publication: 2020 Dec 01.
Typ publikacji:: Journal Article
MeSH Terms:: Antineoplastic Agents/*chemistry
Indicators and Reagents/*chemistry
Naphthyridines/*chemistry
Models, Molecular ; Molecular Structure ; Stereoisomerism ; Structure-Activity Relationship

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Skocz do pozycji: 13.

Tytuł:: Autologous culture method improves retention of tumors' native properties.
Autorzy:: Tang Y; Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology, Department of Pathology and Pathophysiology, Shantou University Medical College, Shantou, 515041, Guangdong, China. .; Dalian Municipal Central Hospital, Dalian, 116033, Liaoning, China. .
Xu Q; Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology, Department of Pathology and Pathophysiology, Shantou University Medical College, Shantou, 515041, Guangdong, China.
Yan M; Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology, Department of Pathology and Pathophysiology, Shantou University Medical College, Shantou, 515041, Guangdong, China.
Zhang Y; Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology, Department of Pathology and Pathophysiology, Shantou University Medical College, Shantou, 515041, Guangdong, China.
Zhu P; Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology, Department of Pathology and Pathophysiology, Shantou University Medical College, Shantou, 515041, Guangdong, China.
Li X; Department of Pathology, Beijing University Cancer Hospital, Beijing, 100142, China.
Sang L; Dalian Municipal Central Hospital, Dalian, 116033, Liaoning, China.
Zhang M; Dalian Municipal Central Hospital, Dalian, 116033, Liaoning, China.
Huang W; Cancer Hospital of Shantou University Medical College, Shantou, 515041, Guangdong, China.
Lin L; Shantou Central Hospital, Shantou, 515041, Guangdong, China.
Wu J; Cancer Hospital of Shantou University Medical College, Shantou, 515041, Guangdong, China.
Xin Y; Dalian Municipal Central Hospital, Dalian, 116033, Liaoning, China.
Fu J; Shantou Central Hospital, Shantou, 515041, Guangdong, China.
Zhang L; Dalian Municipal Central Hospital, Dalian, 116033, Liaoning, China.
Zhang S; Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology, Department of Pathology and Pathophysiology, Shantou University Medical College, Shantou, 515041, Guangdong, China.
Gu J; Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology, Department of Pathology and Pathophysiology, Shantou University Medical College, Shantou, 515041, Guangdong, China. .; Jinxin Research Institute for Reproductive Medicine and Genetics, Chengdu Jinjiang Hospital for Maternal and Child Health Care, Chengdu, 610066, Sichuan, China. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2020 Nov 24; Vol. 10 (1), pp. 20455. Date of Electronic Publication: 2020 Nov 24.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Antineoplastic Agents/*pharmacology
Body Fluids/*cytology
Cell Culture Techniques/*methods
Neoplasms/*pathology
Serum/*cytology
Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/metabolism ; Body Fluids/drug effects ; Body Fluids/metabolism ; Cell Proliferation ; Cell Survival ; Cells, Cultured ; Drug Resistance, Neoplasm ; Female ; Humans ; Male ; Middle Aged ; Models, Biological ; Neoplasms/metabolism ; Serum/drug effects ; Serum/metabolism ; Tissue Scaffolds

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Skocz do pozycji: 14.

Tytuł:: Cancer-targeted design of bioresponsive prodrug with enhanced cellular uptake to achieve precise cancer therapy.
Autorzy:: Liang Y; a The First Affiliated Hospital, and Department of Chemistry , Jinan University , Guangzhou , China.
Huang W; a The First Affiliated Hospital, and Department of Chemistry , Jinan University , Guangzhou , China.
Zeng D; a The First Affiliated Hospital, and Department of Chemistry , Jinan University , Guangzhou , China.
Huang X; a The First Affiliated Hospital, and Department of Chemistry , Jinan University , Guangzhou , China.
Chan L; a The First Affiliated Hospital, and Department of Chemistry , Jinan University , Guangzhou , China.
Mei C; a The First Affiliated Hospital, and Department of Chemistry , Jinan University , Guangzhou , China.
Feng P; a The First Affiliated Hospital, and Department of Chemistry , Jinan University , Guangzhou , China.
Tan CH; b Division of Chemistry and Biological Chemistry , Nanyang Technological University , Singapore.
Chen T; a The First Affiliated Hospital, and Department of Chemistry , Jinan University , Guangzhou , China.; Pokaż więcej
Źródło:: Drug delivery [Drug Deliv] 2018 Nov; Vol. 25 (1), pp. 1350-1361.
Typ publikacji:: Journal Article
MeSH Terms:: Antineoplastic Agents/*administration & dosage
Antineoplastic Agents/*chemistry
Biological Transport/*drug effects
Neoplasms/*drug therapy
Prodrugs/*chemistry
Animals ; Apoptosis/drug effects ; Camptothecin/administration & dosage ; Camptothecin/chemistry ; Cell Line, Tumor ; Drug Delivery Systems/methods ; Glutathione/chemistry ; Hep G2 Cells ; Humans ; MCF-7 Cells ; Mice ; Mice, Nude

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Skocz do pozycji: 15.

Tytuł:: Design, synthesis and evaluation of a novel series of inhibitors reversing P-glycoprotein-mediated multidrug resistance.
Autorzy:: Ghaleb H; Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.
Li H; Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.
Kairuki M; Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.
Qiu Q; Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.
Bi X; Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.
Liu C; Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.
Liao C; Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.
Li J; Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.
Hezam K; Antibody Engineering Laboratory, School of Life Science and Technology, China Pharmaceutical University, Nanjing, China.
Huang W; Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.; Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, China Pharmaceutical University, Nanjing, China.
Qian H; Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.; Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, China Pharmaceutical University, Nanjing, China.; Pokaż więcej
Źródło:: Chemical biology & drug design [Chem Biol Drug Des] 2018 Sep; Vol. 92 (3), pp. 1708-1716. Date of Electronic Publication: 2018 Jun 14.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Drug Design*
ATP Binding Cassette Transporter, Subfamily B, Member 1/*antagonists & inhibitors
Antineoplastic Agents/*chemical synthesis
ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism ; Antineoplastic Agents/pharmacology ; Binding Sites ; Cell Survival ; Click Chemistry ; Doxorubicin/chemistry ; Doxorubicin/metabolism ; Doxorubicin/pharmacology ; Drug Resistance, Neoplasm/drug effects ; Humans ; K562 Cells ; Microscopy, Confocal ; Molecular Docking Simulation ; Protein Structure, Tertiary ; Rhodamines/chemistry ; Rhodamines/metabolism ; Structure-Activity Relationship

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Skocz do pozycji: 16.

Tytuł:: Inhibition of thioredoxin activates mitophagy and overcomes adaptive bortezomib resistance in multiple myeloma.
Autorzy:: Zheng Z; Department of Hematology, Fujian Provincial Key Laboratory of Hematology, Fujian Medical University Union Hospital, 29 Xinquan Road, Fuzhou, Fujian, 350001, China.; Division of Hematologic Malignancies and Cellular Therapy, Duke University Medical Center, 3961, Durham, NC, 27710, USA.
Fan S; Division of Hematologic Malignancies and Cellular Therapy, Duke University Medical Center, 3961, Durham, NC, 27710, USA.
Zheng J; Department of Hematology, Fujian Provincial Key Laboratory of Hematology, Fujian Medical University Union Hospital, 29 Xinquan Road, Fuzhou, Fujian, 350001, China.
Huang W; Division of Hematologic Malignancies and Cellular Therapy, Duke University Medical Center, 3961, Durham, NC, 27710, USA.
Gasparetto C; Division of Hematologic Malignancies and Cellular Therapy, Duke University Medical Center, 3961, Durham, NC, 27710, USA.
Chao NJ; Division of Hematologic Malignancies and Cellular Therapy, Duke University Medical Center, 3961, Durham, NC, 27710, USA.
Hu J; Department of Hematology, Fujian Provincial Key Laboratory of Hematology, Fujian Medical University Union Hospital, 29 Xinquan Road, Fuzhou, Fujian, 350001, China. .
Kang Y; Division of Hematologic Malignancies and Cellular Therapy, Duke University Medical Center, 3961, Durham, NC, 27710, USA. .; Pokaż więcej
Źródło:: Journal of hematology & oncology [J Hematol Oncol] 2018 Feb 27; Vol. 11 (1), pp. 29. Date of Electronic Publication: 2018 Feb 27.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Antineoplastic Agents/*pharmacology
Bortezomib/*pharmacology
Drug Resistance, Neoplasm/*drug effects
Mitophagy/*drug effects
Multiple Myeloma/*drug therapy
Thioredoxins/*antagonists & inhibitors
Thioredoxins/*genetics
Animals ; Cell Line, Tumor ; Humans ; Mice, Inbred NOD ; Mice, SCID ; Multiple Myeloma/genetics ; Multiple Myeloma/pathology ; Up-Regulation/drug effects

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Skocz do pozycji: 17.

Tytuł:: Characterization and validation of potential therapeutic targets based on the molecular signature of patient-derived xenografts in gastric cancer.
Autorzy:: Chen Z; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Fu-Cheng Road 52, Hai-Dian District, Beijing, 100142, China.
Huang W; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Fu-Cheng Road 52, Hai-Dian District, Beijing, 100142, China.
Tian T; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Fu-Cheng Road 52, Hai-Dian District, Beijing, 100142, China.
Zang W; Novogene Bioinformatics Institute, Beijing, China.
Wang J; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Fu-Cheng Road 52, Hai-Dian District, Beijing, 100142, China.
Liu Z; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Fu-Cheng Road 52, Hai-Dian District, Beijing, 100142, China.
Li Z; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Pathology, Peking University Cancer Hospital and Institute, Beijing, China.
Lai Y; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Pathology, Peking University Cancer Hospital and Institute, Beijing, China.
Jiang Z; Novogene Bioinformatics Institute, Beijing, China.
Gao J; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Fu-Cheng Road 52, Hai-Dian District, Beijing, 100142, China. gaojing_.
Shen L; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Fu-Cheng Road 52, Hai-Dian District, Beijing, 100142, China. .; Pokaż więcej
Źródło:: Journal of hematology & oncology [J Hematol Oncol] 2018 Feb 13; Vol. 11 (1), pp. 20. Date of Electronic Publication: 2018 Feb 13.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Gene Expression Regulation, Neoplastic*/drug effects
Transcriptome*/drug effects
Antineoplastic Agents/*therapeutic use
Stomach Neoplasms/*drug therapy
Stomach Neoplasms/*genetics
Animals ; Antineoplastic Agents/pharmacology ; Humans ; Mice, Inbred NOD ; Mice, SCID ; Molecular Targeted Therapy/methods ; Signal Transduction/drug effects ; Stomach Neoplasms/metabolism ; Stomach Neoplasms/pathology ; Xenograft Model Antitumor Assays/methods

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Skocz do pozycji: 18.

Tytuł:: Isolation and identification of human metabolites from a novel anti-tumor candidate drug 5-chlorogenic acid injection by HPLC-HRMS/MS and HPLC-SPE-NMR.
Autorzy:: Ren T; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Sciences, No. 2 Nanwei Street, Xicheng District, Beijing, 100050, China.
Wang Y; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Sciences, No. 2 Nanwei Street, Xicheng District, Beijing, 100050, China.
Wang C; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Sciences, No. 2 Nanwei Street, Xicheng District, Beijing, 100050, China.
Zhang M; Jiuzhang Biochemical Engineering Science and Technology Development Co., Ltd., Chengdu, Sichuan, 610041, China.
Huang W; Jiuzhang Biochemical Engineering Science and Technology Development Co., Ltd., Chengdu, Sichuan, 610041, China.
Jiang J; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Sciences, No. 2 Nanwei Street, Xicheng District, Beijing, 100050, China. .
Li W; Department of Glioma, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, China. .
Zhang J; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Sciences, No. 2 Nanwei Street, Xicheng District, Beijing, 100050, China. .; Pokaż więcej
Źródło:: Analytical and bioanalytical chemistry [Anal Bioanal Chem] 2017 Dec; Vol. 409 (30), pp. 7035-7048. Date of Electronic Publication: 2017 Nov 07.
Typ publikacji:: Journal Article
MeSH Terms:: Antineoplastic Agents/*metabolism
Chlorogenic Acid/*metabolism
Chromatography, High Pressure Liquid/*methods
Magnetic Resonance Spectroscopy/*methods
Mass Spectrometry/*methods
Adult ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/urine ; Chlorogenic Acid/chemistry ; Chlorogenic Acid/urine ; Feces/chemistry ; Female ; Humans ; Male ; Middle Aged ; Molecular Structure

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Skocz do pozycji: 19.

Tytuł:: Synthesis and biological evaluation of novel peptides based on antimicrobial peptides as potential agents with antitumor and multidrug resistance-reversing activities.
Autorzy:: Zhang B; Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.
Shi W; Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.
Li J; Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.
Liao C; Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.
Yang L; Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.
Huang W; Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.; Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, China Pharmaceutical University, Nanjing, China.
Qian H; Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.; Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, China Pharmaceutical University, Nanjing, China.; Pokaż więcej
Źródło:: Chemical biology & drug design [Chem Biol Drug Des] 2017 Nov; Vol. 90 (5), pp. 972-980. Date of Electronic Publication: 2017 Jun 28.
Typ publikacji:: Journal Article
MeSH Terms:: Antimicrobial Cationic Peptides/*chemistry
Antimicrobial Cationic Peptides/*pharmacology
Antineoplastic Agents/*chemistry
Antineoplastic Agents/*pharmacology
Neoplasms/*drug therapy
Oligopeptides/*chemistry
Oligopeptides/*pharmacology
Amino Acid Sequence ; Antimicrobial Cationic Peptides/chemical synthesis ; Antineoplastic Agents/chemical synthesis ; Apoptosis/drug effects ; Cell Line, Tumor ; Drug Resistance, Multiple/drug effects ; Humans ; Oligopeptides/chemical synthesis ; Solid-Phase Synthesis Techniques

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Skocz do pozycji: 20.

Tytuł:: Mitochondria targeting and near-infrared fluorescence imaging of a novel heptamethine cyanine anticancer agent.
Autorzy:: Ning J; Institute for Nanobiomedical Technology and Membrane Biology, Laboratory of Ethnopharmacology, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
Huang B; Institute for Nanobiomedical Technology and Membrane Biology, Laboratory of Ethnopharmacology, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
Wei Z; Institute for Nanobiomedical Technology and Membrane Biology, Laboratory of Ethnopharmacology, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
Li W; Regenerative Medicine Research Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
Zheng H; Department of Integrated Traditional Chinese and Western Medicine, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
Ma L; Regenerative Medicine Research Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
Xing Z; Institute for Nanobiomedical Technology and Membrane Biology, Laboratory of Ethnopharmacology, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
Niu H; Institute for Nanobiomedical Technology and Membrane Biology, Laboratory of Ethnopharmacology, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
Huang W; Institute for Nanobiomedical Technology and Membrane Biology, Laboratory of Ethnopharmacology, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, P.R. China.; Pokaż więcej
Źródło:: Molecular medicine reports [Mol Med Rep] 2017 Jun; Vol. 15 (6), pp. 3761-3766. Date of Electronic Publication: 2017 Apr 10.
Typ publikacji:: Journal Article
MeSH Terms:: Carbocyanines*
Fluorescent Dyes*
Molecular Imaging*/methods
Optical Imaging*/methods
Antineoplastic Agents/*therapeutic use
Mitochondria/*drug effects
Mitochondria/*metabolism
Animals ; Antineoplastic Agents/chemistry ; Cell Line, Tumor ; Cell Survival ; Melanoma, Experimental ; Mice ; Microscopy, Confocal

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