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Wyświetlanie 1-3 z 3
Tytuł :
Thrombin Provokes Degranulation of Platelet α-Granules Leading to the Release of Active Plasminogen Activator Inhibitor-1 (PAI-1).
Autorzy :
Huebner BR; Department of Surgery, University of Colorado, Aurora, Colorado.
Moore EE; Department of Surgery, University of Colorado, Aurora, Colorado.; Department of Surgery, Denver Health Medical Center, Denver, Colorado.
Moore HB; Department of Surgery, University of Colorado, Aurora, Colorado.
Stettler GR; Department of Surgery, University of Colorado, Aurora, Colorado.
Nunns GR; Department of Surgery, University of Colorado, Aurora, Colorado.
Lawson P; Department of Surgery, University of Colorado, Aurora, Colorado.
Sauaia A; Department of Surgery, University of Colorado, Aurora, Colorado.; Department of Surgery, Denver Health Medical Center, Denver, Colorado.
Kelher M; Department of Surgery, University of Colorado, Aurora, Colorado.; Bonfils Blood Center, Denver, Colorado.
Banerjee A; Department of Surgery, University of Colorado, Aurora, Colorado.
Silliman CC; Bonfils Blood Center, Denver, Colorado.; Department of Pediatrics, University of Colorado, Aurora, Colorado.
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Źródło :
Shock (Augusta, Ga.) [Shock] 2018 Dec; Vol. 50 (6), pp. 671-676.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cytoplasmic Granules/*drug effects
Cytoplasmic Granules/*metabolism
Plasminogen Activator Inhibitor 1/*metabolism
Thrombin/*pharmacology
Blood Platelets/drug effects ; Blood Platelets/metabolism ; Enzyme-Linked Immunosorbent Assay ; Humans ; Thrombelastography ; Tissue Plasminogen Activator/metabolism
Czasopismo naukowe
Tytuł :
Thrombin stimulates increased plasminogen activator inhibitor-1 release from liver compared to lung endothelium.
Autorzy :
Huebner BR; Department of Surgery, University of Colorado, Aurora, Colorado. Electronic address: .
Moore EE; Department of Surgery, University of Colorado, Aurora, Colorado; Department of Surgery, Denver Health Medical Center, Denver, Colorado.
Moore HB; Department of Surgery, University of Colorado, Aurora, Colorado.
Gonzalez E; Department of Surgery, University of Colorado, Aurora, Colorado.
Kelher MR; Bonfils Blood Center, Denver, Colorado.
Sauaia A; Department of Surgery, University of Colorado, Aurora, Colorado; Department of Surgery, Denver Health Medical Center, Denver, Colorado.
Banerjee A; Department of Surgery, University of Colorado, Aurora, Colorado.
Silliman CC; Bonfils Blood Center, Denver, Colorado; Department of Pediatrics, University of Colorado, Aurora, Colorado.
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Źródło :
The Journal of surgical research [J Surg Res] 2018 May; Vol. 225, pp. 1-5. Date of Electronic Publication: 2018 Jan 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Endothelial Cells/*metabolism
Fibrinolysis/*physiology
Liver/*metabolism
Lung/*metabolism
Plasminogen Activator Inhibitor 1/*metabolism
Thrombin/*metabolism
Cells, Cultured ; Cycloheximide/pharmacology ; Endothelium, Vascular/cytology ; Endothelium, Vascular/metabolism ; Enzyme-Linked Immunosorbent Assay ; Humans ; Liver/cytology ; Lung/cytology ; Plasminogen Activator Inhibitor 1/analysis ; Protein Biosynthesis/drug effects ; Protein Synthesis Inhibitors/pharmacology ; Thrombosis/etiology ; Thrombosis/physiopathology ; Tissue Plasminogen Activator/metabolism ; Wounds and Injuries/complications ; Wounds and Injuries/physiopathology
Czasopismo naukowe
Tytuł :
Fibrinolysis shutdown is associated with a fivefold increase in mortality in trauma patients lacking hypersensitivity to tissue plasminogen activator.
Autorzy :
Moore HB; From the Department of Surgery (H.B.M., E.E.M., B.R.H., M.D., G.R.S., G.R.N., P.J.L., A.B., C.S., A.S., K.C.H.), University of Colorado; Denver Health Medical Center (E.E.M., A.G., J.C.); and University of Colorado School of Public Health (A.S.), Denver, Colorado.
Moore EE
Huebner BR
Dzieciatkowska M
Stettler GR
Nunns GR
Lawson PJ
Ghasabyan A
Chandler J
Banerjee A
Silliman C
Sauaia A
Hansen KC
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Źródło :
The journal of trauma and acute care surgery [J Trauma Acute Care Surg] 2017 Dec; Vol. 83 (6), pp. 1014-1022.
Typ publikacji :
Journal Article; Observational Study; Research Support, N.I.H., Extramural
MeSH Terms :
Blood Coagulation Disorders/*blood
Fibrinolysis/*physiology
Plasminogen Activator Inhibitor 1/*blood
Wounds and Injuries/*complications
Adult ; Biomarkers/blood ; Blood Coagulation Disorders/etiology ; Blood Coagulation Disorders/mortality ; Enzyme-Linked Immunosorbent Assay ; Female ; Follow-Up Studies ; Humans ; Injury Severity Score ; Male ; Middle Aged ; Phenotype ; Prognosis ; Prospective Studies ; Proteomics ; Thrombelastography ; Wounds and Injuries/blood ; Wounds and Injuries/diagnosis
Czasopismo naukowe
    Wyświetlanie 1-3 z 3

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