Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ

Wyszukujesz frazę ""Huntingtin Protein"" wg kryterium: Temat


Tytuł :
Huntingtin fibrils with different toxicity, structure, and seeding potential can be interconverted.
Autorzy :
Mario Isas J; Department of Physiology & Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Pandey NK; Department of Physiology & Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Xu H; Department of Physiology & Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Teranishi K; Department of Physiology & Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Okada AK; Department of Physiology & Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.; Department of Emergency Medicine, Regions Hospital, St. Paul, MN, USA.
Fultz EK; Department of Physiology & Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Rawat A; Department of Physiology & Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Applebaum A; Department of Physiology & Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Meier F; Department of Physiology & Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Chen J; Department of Physiology & Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Langen R; Department of Physiology & Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. .
Siemer AB; Department of Physiology & Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. .
Pokaż więcej
Źródło :
Nature communications [Nat Commun] 2021 Jul 13; Vol. 12 (1), pp. 4272. Date of Electronic Publication: 2021 Jul 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Huntingtin Protein/*metabolism
Huntington Disease/*metabolism
Neurodegenerative Diseases/*metabolism
Humans ; Huntingtin Protein/genetics ; Huntington Disease/genetics ; Neurodegenerative Diseases/genetics ; Peptides/chemistry ; Peptides/metabolism ; Protein Interaction Maps
Czasopismo naukowe
Tytuł :
Involvement of Huntingtin in Development and Ciliary Beating Regulation of Larvae of the Sea Urchin, Hemicentrotus pulcherrimus .
Autorzy :
Katow H; Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan.; Research Center for Marine Biology, Tohoku University, Aomori 039-3501, Japan.
Katow T; Research Center for Marine Biology, Tohoku University, Aomori 039-3501, Japan.
Yoshida H; Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan.
Kiyomoto M; Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan.; Marine and Coastal Research Center, Ochanomizu University, Chiba 294-0301, Japan.
Pokaż więcej
Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 May 12; Vol. 22 (10). Date of Electronic Publication: 2021 May 12.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Developmental*
Swimming*
Cilia/*physiology
Huntingtin Protein/*metabolism
Larva/*physiology
Sea Urchins/*physiology
Amino Acid Sequence ; Animals ; Huntingtin Protein/genetics ; Sequence Homology
Czasopismo naukowe
Tytuł :
Huntingtin: A Protein with a Peculiar Solvent Accessible Surface.
Autorzy :
Babbi G; Biocomputing Group, University of Bologna, Via San Giacomo 9/2, 40126 Bologna, Italy.
Savojardo C; Biocomputing Group, University of Bologna, Via San Giacomo 9/2, 40126 Bologna, Italy.
Martelli PL; Biocomputing Group, University of Bologna, Via San Giacomo 9/2, 40126 Bologna, Italy.
Casadio R; Biocomputing Group, University of Bologna, Via San Giacomo 9/2, 40126 Bologna, Italy.; Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies, National Research Council, Via Giovanni Amendola 122/O, 70126 Bari, Italy.
Pokaż więcej
Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 12; Vol. 22 (6). Date of Electronic Publication: 2021 Mar 12.
Typ publikacji :
Journal Article
MeSH Terms :
Computational Biology*
Calcium/*metabolism
Huntingtin Protein/*chemistry
Proteins/*genetics
Binding Sites/genetics ; Humans ; Huntingtin Protein/genetics ; Huntingtin Protein/ultrastructure ; Hydrophobic and Hydrophilic Interactions ; Models, Molecular ; Protein Binding/genetics ; Solvents/chemistry ; Surface Properties
Czasopismo naukowe
Tytuł :
The Proteasome Activators Blm10/PA200 Enhance the Proteasomal Degradation of N-Terminal Huntingtin.
Autorzy :
Aladdin A; Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.; Doctoral School of Molecular Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Yao Y; Department of Biochemistry and Molecular Cell Biology, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China.; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10460, USA.
Yang C; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10460, USA.; Departments of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Kahlert G; Institute for Systems Biology, Seattle, WA 98109, USA.
Ghani M; Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.; Doctoral School of Molecular Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Király N; Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.; Doctoral School of Molecular Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Boratkó A; Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Uray K; Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Dittmar G; Proteomics of Cellular Signalling, Luxembourg Institute of Health, 1445 Strassen, Luxembourg.; Department of Life Science and Medicine, University of Luxembourg, 4365 Esch-sur-Alzette, Luxembourg.
Tar K; Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10460, USA.
Pokaż więcej
Źródło :
Biomolecules [Biomolecules] 2020 Nov 20; Vol. 10 (11). Date of Electronic Publication: 2020 Nov 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Huntingtin Protein/*genetics
Huntingtin Protein/*metabolism
Nuclear Proteins/*metabolism
Proteasome Endopeptidase Complex/*chemistry
Proteasome Endopeptidase Complex/*metabolism
Saccharomyces cerevisiae Proteins/*metabolism
Cell Line, Tumor ; Cell Survival ; Gene Knockdown Techniques ; Humans ; Huntingtin Protein/chemistry ; Models, Molecular ; Nuclear Proteins/chemistry ; Nuclear Proteins/genetics ; Peptides/metabolism ; Proteasome Endopeptidase Complex/genetics ; Protein Aggregates ; Proteolysis ; Saccharomyces cerevisiae/enzymology ; Saccharomyces cerevisiae Proteins/chemistry ; Saccharomyces cerevisiae Proteins/genetics
Czasopismo naukowe
Tytuł :
Analysis of mutant and total huntingtin expression in Huntington's disease murine models.
Autorzy :
Fodale V; Department of Translational Biology, IRBM S.p.A., via Pontina Km 30, 600, Pomezia, Rome, Italy.
Pintauro R; Department of Translational Biology, IRBM S.p.A., via Pontina Km 30, 600, Pomezia, Rome, Italy.
Daldin M; Department of Translational Biology, IRBM S.p.A., via Pontina Km 30, 600, Pomezia, Rome, Italy.
Altobelli R; Department of Translational Biology, IRBM S.p.A., via Pontina Km 30, 600, Pomezia, Rome, Italy.
Spiezia MC; Department of Translational Biology, IRBM S.p.A., via Pontina Km 30, 600, Pomezia, Rome, Italy.
Bisbocci M; Department of Translational Biology, IRBM S.p.A., via Pontina Km 30, 600, Pomezia, Rome, Italy.
Macdonald D; CHDI Management/CHDI Foundation, Suite 700, 6080 Centre Drive, Los Angeles, CA, USA. .
Bresciani A; Department of Translational Biology, IRBM S.p.A., via Pontina Km 30, 600, Pomezia, Rome, Italy.
Pokaż więcej
Źródło :
Scientific reports [Sci Rep] 2020 Dec 17; Vol. 10 (1), pp. 22137. Date of Electronic Publication: 2020 Dec 17.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression*
Mutation*
Huntingtin Protein/*genetics
Huntington Disease/*genetics
Animals ; Biomarkers ; Brain/metabolism ; Brain/pathology ; Disease Models, Animal ; Fibroblasts/metabolism ; Gene Knock-In Techniques ; Humans ; Huntingtin Protein/cerebrospinal fluid ; Huntingtin Protein/metabolism ; Huntington Disease/drug therapy ; Huntington Disease/metabolism ; Huntington Disease/pathology ; Immunoassay ; Immunohistochemistry ; Mice ; Rats ; Reproducibility of Results
Czasopismo naukowe
Tytuł :
Disease-related Huntingtin seeding activities in cerebrospinal fluids of Huntington's disease patients.
Autorzy :
Lee CYD; Center for Neurobehavioral Genetics, The Jane and Terry Semel Institute for Neuroscience & Human Behavior, University of California, Los Angeles, Los Angeles, USA.; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Wang N; Center for Neurobehavioral Genetics, The Jane and Terry Semel Institute for Neuroscience & Human Behavior, University of California, Los Angeles, Los Angeles, USA.; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Shen K; Department of Biology and BioX Program, Stanford University, Stanford, CA, USA.; Department of Molecular and Cell Biology, UC Berkeley, Berkeley, CA, USA.
Stricos M; Center for Neurobehavioral Genetics, The Jane and Terry Semel Institute for Neuroscience & Human Behavior, University of California, Los Angeles, Los Angeles, USA.; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Langfelder P; Center for Neurobehavioral Genetics, The Jane and Terry Semel Institute for Neuroscience & Human Behavior, University of California, Los Angeles, Los Angeles, USA.; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Cheon KH; Center for Neurobehavioral Genetics, The Jane and Terry Semel Institute for Neuroscience & Human Behavior, University of California, Los Angeles, Los Angeles, USA.; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Cortés EP; Division of Aging and Dementia, Department of Neurology, Columbia University Medical Center, New York, NY, USA.
Vinters HV; Department of Pathology and Laboratory Medicine, Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Vonsattel JP; Division of Aging and Dementia, Department of Neurology, Columbia University Medical Center, New York, NY, USA.
Wexler NS; Departments of Neurology and Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Hereditary Disease Foundation, New York, NY, USA.
Damoiseaux R; California NanoSystems Institute, University of California, Los Angeles, CA, USA.; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA, USA.
Frydman J; Department of Biology and BioX Program, Stanford University, Stanford, CA, USA.
Yang XW; Center for Neurobehavioral Genetics, The Jane and Terry Semel Institute for Neuroscience & Human Behavior, University of California, Los Angeles, Los Angeles, USA. .; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. .
Pokaż więcej
Źródło :
Scientific reports [Sci Rep] 2020 Nov 20; Vol. 10 (1), pp. 20295. Date of Electronic Publication: 2020 Nov 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cerebrospinal Fluid/*metabolism
HSP40 Heat-Shock Proteins/*metabolism
Huntingtin Protein/*metabolism
Huntington Disease/*pathology
Molecular Chaperones/*metabolism
Nerve Tissue Proteins/*metabolism
Protein Aggregation, Pathological/*pathology
Adult ; Aged ; Aged, 80 and over ; Brain/pathology ; Cell Line ; Exons/genetics ; Female ; Genes, Reporter/genetics ; HSP40 Heat-Shock Proteins/genetics ; Humans ; Huntingtin Protein/cerebrospinal fluid ; Huntingtin Protein/genetics ; Huntington Disease/cerebrospinal fluid ; Huntington Disease/genetics ; Intravital Microscopy ; Male ; Middle Aged ; Molecular Chaperones/genetics ; Mutation ; Nerve Tissue Proteins/genetics ; Protein Aggregation, Pathological/cerebrospinal fluid ; Protein Aggregation, Pathological/genetics ; Protein Domains/genetics ; Protein Engineering ; Protein Folding
Czasopismo naukowe
Tytuł :
Mutant Huntingtin Is Cleared from the Brain via Active Mechanisms in Huntington Disease.
Autorzy :
Caron NS; Centre for Molecular Medicine and Therapeutics, British Columbia Children's Hospital Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada.
Banos R; Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida 32828.
Yanick C; Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida 32828.
Aly AE; Centre for Molecular Medicine and Therapeutics, British Columbia Children's Hospital Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada.
Byrne LM; UCL Huntington's Disease Centre, UCL Queen Square Institute of Neurology, University College London, London, WC1N 3BG, United Kingdom.
Smith ED; Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida 32828.
Xie Y; Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida 32828.
Smith SEP; Seattle Children's Research Institute, Center for Integrative Brain Research, Seattle, Washington 98101.
Potluri N; Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida 32828.
Findlay Black H; Centre for Molecular Medicine and Therapeutics, British Columbia Children's Hospital Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada.
Casal L; Centre for Molecular Medicine and Therapeutics, Vancouver, British Columbia V5Z 4H4, Canada.
Ko S; Centre for Molecular Medicine and Therapeutics, Vancouver, British Columbia V5Z 4H4, Canada.
Cheung D; Centre for Molecular Medicine and Therapeutics, Vancouver, British Columbia V5Z 4H4, Canada.
Kim H; Department of Biological Sciences, KAIST, Daejeon, Korea, 34141.
Seong IS; Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02114.
Wild EJ; UCL Huntington's Disease Centre, UCL Queen Square Institute of Neurology, University College London, London, WC1N 3BG, United Kingdom.
Song JJ; Department of Biological Sciences, KAIST, Daejeon, Korea, 34141.
Hayden MR; Centre for Molecular Medicine and Therapeutics, British Columbia Children's Hospital Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada .
Southwell AL; Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida 32828 .
Pokaż więcej
Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2021 Jan 27; Vol. 41 (4), pp. 780-796. Date of Electronic Publication: 2020 Dec 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain Chemistry*
Huntingtin Protein/*cerebrospinal fluid
Huntington Disease/*cerebrospinal fluid
Animals ; Astrocytes/metabolism ; Biomarkers/cerebrospinal fluid ; Female ; Glymphatic System/metabolism ; Humans ; Huntingtin Protein/genetics ; Huntington Disease/genetics ; Male ; Mice ; Mice, Transgenic ; Mutation ; Neurons/metabolism ; Trinucleotide Repeat Expansion
Czasopismo naukowe
Tytuł :
PIAS1 modulates striatal transcription, DNA damage repair, and SUMOylation with relevance to Huntington's disease.
Autorzy :
Morozko EL; Department of Neurobiology and Behavior, University of California, Irvine, CA 92697.
Smith-Geater C; Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697.
Monteys AM; Raymond G. Perelman Center for Cell and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104.
Pradhan S; Department of Neurology, University of Texas Medical Branch, Galveston, TX 77555.
Lim RG; Institute of Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697.
Langfelder P; Department of Human Genetics, David Geffen School of Medicine at University of California, Los Angeles, CA 90095.
Kachemov M; Department of Neurobiology and Behavior, University of California, Irvine, CA 92697.
Hill A; Incisive Genetics Inc., Vancouver, BC, Canada V6A 0H9.
Stocksdale JT; Department of Neurobiology and Behavior, University of California, Irvine, CA 92697.
Cullis PR; NanoMedicines Innovation Network, University of British Columbia, Vancouver, BC, Canada V6T 1Z3.; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada V6T 1Z3.
Wu J; Department of Biological Chemistry, University of California, Irvine, CA 92697.
Ochaba J; Department of Neurobiology and Behavior, University of California, Irvine, CA 92697.
Miramontes R; Institute of Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697.
Chakraborty A; Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555.
Hazra TK; Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555.
Lau A; Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697.
St-Cyr S; Raymond G. Perelman Center for Cell and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104.
Orellana I; Sue and Bill Gross Stem Cell Institute, University of California, Irvine, CA 92697.
Kopan L; Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697.
Wang KQ; Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697.
Yeung S; Institute of Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697.
Leavitt BR; Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, BC, Canada V5Z 4H4.
Reidling JC; Institute of Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697.
Yang XW; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095.
Steffan JS; Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697.; Institute of Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697.
Davidson BL; Raymond G. Perelman Center for Cell and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104.; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Sarkar PS; Department of Neurology, University of Texas Medical Branch, Galveston, TX 77555.; Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX 77555.
Thompson LM; Department of Neurobiology and Behavior, University of California, Irvine, CA 92697; .; Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697.; Institute of Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697.; Department of Biological Chemistry, University of California, Irvine, CA 92697.; Sue and Bill Gross Stem Cell Institute, University of California, Irvine, CA 92697.
Pokaż więcej
Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Jan 26; Vol. 118 (4).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
DNA Repair*
Protein Processing, Post-Translational*
DNA/*genetics
DNA Repair Enzymes/*genetics
Huntingtin Protein/*genetics
Huntington Disease/*genetics
Phosphotransferases (Alcohol Group Acceptor)/*genetics
Protein Inhibitors of Activated STAT/*genetics
Small Ubiquitin-Related Modifier Proteins/*genetics
Animals ; Cell Differentiation ; DNA/metabolism ; DNA Damage ; DNA Repair Enzymes/metabolism ; Disease Models, Animal ; Female ; Humans ; Huntingtin Protein/metabolism ; Huntington Disease/metabolism ; Huntington Disease/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Neurons/metabolism ; Neurons/pathology ; Phosphotransferases (Alcohol Group Acceptor)/metabolism ; Pluripotent Stem Cells/metabolism ; Pluripotent Stem Cells/pathology ; Primary Cell Culture ; Protein Inhibitors of Activated STAT/antagonists & inhibitors ; Protein Inhibitors of Activated STAT/metabolism ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Small Ubiquitin-Related Modifier Proteins/antagonists & inhibitors ; Small Ubiquitin-Related Modifier Proteins/metabolism ; Sumoylation ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
The evolution of the huntingtin-associated protein 40 (HAP40) in conjunction with huntingtin.
Autorzy :
Seefelder M; Department of Gene Therapy, Ulm University, 89081, Ulm, Germany.
Alva V; Department of Protein Evolution, Max Planck Institute for Developmental Biology, Max-Planck-Ring 5, 72076, Tübingen, Germany.
Huang B; Department of Gene Therapy, Ulm University, 89081, Ulm, Germany.
Engler T; Department of Gene Therapy, Ulm University, 89081, Ulm, Germany.
Baumeister W; Department of Molecular Structural Biology, Max Planck Institute of Biochemistry, 82152, Martinsried, Germany.
Guo Q; Department of Molecular Structural Biology, Max Planck Institute of Biochemistry, 82152, Martinsried, Germany.; Peking-Tsinghua Joint Center for Life Sciences, School of Life Sciences, Peking University, Beijing, 100871, China.
Fernández-Busnadiego R; Department of Molecular Structural Biology, Max Planck Institute of Biochemistry, 82152, Martinsried, Germany.; Institute of Neuropathology, University Medical Center Göttingen, 37099, Göttingen, Germany.; Cluster of Excellence 'Multiscale Bioimaging: From Molecular Machines To Networks of Excitable Cells' (MBExC), University of Göttingen, Göttingen, Germany.
Lupas AN; Department of Protein Evolution, Max Planck Institute for Developmental Biology, Max-Planck-Ring 5, 72076, Tübingen, Germany. .
Kochanek S; Department of Gene Therapy, Ulm University, 89081, Ulm, Germany. .
Pokaż więcej
Źródło :
BMC evolutionary biology [BMC Evol Biol] 2020 Dec 09; Vol. 20 (1), pp. 162. Date of Electronic Publication: 2020 Dec 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dictyostelium*
Eukaryota*/classification
Eukaryota*/genetics
Huntingtin Protein*/genetics
Huntington Disease*
Nuclear Proteins*/genetics
Animals ; Evolution, Molecular
Czasopismo naukowe
Tytuł :
The β-turn-supporting motif in the polyglutamine binding peptide QBP1 is essential for inhibiting huntingtin aggregation.
Autorzy :
Belwal VK; Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, India.
Datta D; Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, India.
Chaudhary N; Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, India.
Pokaż więcej
Źródło :
FEBS letters [FEBS Lett] 2020 Sep; Vol. 594 (17), pp. 2894-2903. Date of Electronic Publication: 2020 Jul 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Huntingtin Protein/*chemistry
Oligopeptides/*chemistry
Peptides/*chemistry
Amino Acid Motifs ; Amino Acid Substitution ; Cloning, Molecular ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Gene Expression ; Genetic Vectors/chemistry ; Genetic Vectors/metabolism ; Humans ; Huntingtin Protein/genetics ; Huntingtin Protein/metabolism ; Mutation ; Oligopeptides/genetics ; Oligopeptides/metabolism ; Peptides/metabolism ; Protein Aggregates ; Protein Conformation, beta-Strand ; Recombinant Fusion Proteins/chemistry ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/metabolism ; Solutions ; Thioredoxins/chemistry ; Thioredoxins/genetics ; Thioredoxins/metabolism ; Ubiquitin-Protein Ligases/chemistry ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism
Czasopismo naukowe
Tytuł :
Site-specific ubiquitination of pathogenic huntingtin attenuates its deleterious effects.
Autorzy :
Hakim-Eshed V; The Rappaport Faculty of Medicine and Research Institute, 3109601 Haifa, Israel.; Network Biology Research Laboratories, Technion-Israel Institute of Technology, 3200003 Haifa, Israel.
Boulos A; The Rappaport Faculty of Medicine and Research Institute, 3109601 Haifa, Israel.; Network Biology Research Laboratories, Technion-Israel Institute of Technology, 3200003 Haifa, Israel.
Cohen-Rosenzweig C; The Rappaport Faculty of Medicine and Research Institute, 3109601 Haifa, Israel.; The Technion Integrated Cancer Center (TICC), Technion-Israel Institute of Technology, 3109601 Haifa, Israel.
Yu-Taeger L; Department of Human Genetics, Medical Faculty, Ruhr University Bochum, 44801 Bochum, Germany.
Ziv T; Smoler Proteomics Center, Faculty of Biology, Technion-Israel Institute of Technology, 3200003 Haifa, Israel.
Kwon YT; Department of Biomedical Sciences, Protein Metabolism Medical Research Center, College of Medicine, Seoul National University, Seoul, South Korea.
Riess O; Medical Genetics and Applied Genomics Medicine, Eberhard Karl University, 72074 Tuebingen, Germany.
Phuc Nguyen HH; Department of Human Genetics, Medical Faculty, Ruhr University Bochum, 44801 Bochum, Germany.
Ziv NE; The Rappaport Faculty of Medicine and Research Institute, 3109601 Haifa, Israel; .; Network Biology Research Laboratories, Technion-Israel Institute of Technology, 3200003 Haifa, Israel.
Ciechanover A; The Rappaport Faculty of Medicine and Research Institute, 3109601 Haifa, Israel; .; The Technion Integrated Cancer Center (TICC), Technion-Israel Institute of Technology, 3109601 Haifa, Israel.
Pokaż więcej
Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Aug 04; Vol. 117 (31), pp. 18661-18669. Date of Electronic Publication: 2020 Jul 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Huntingtin Protein*/chemistry
Huntingtin Protein*/genetics
Huntingtin Protein*/metabolism
Huntington Disease*/genetics
Huntington Disease*/metabolism
Huntington Disease*/pathology
Ubiquitination/*physiology
Animals ; Brain/cytology ; Brain/metabolism ; Cell Death/physiology ; Cells, Cultured ; Disease Models, Animal ; Humans ; Lysine/chemistry ; Lysine/metabolism ; Neurons/metabolism ; Proteasome Endopeptidase Complex ; Protein Aggregation, Pathological/metabolism ; Rats ; Rats, Transgenic
Czasopismo naukowe
Tytuł :
Wild-type huntingtin regulates human macrophage function.
Autorzy :
O'Regan GC; UCL Huntington's Disease Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK.
Farag SH; UCL Huntington's Disease Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK.
Ostroff GR; Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Two Biotech, Suite 113, Worcester, MA, 01605, USA.
Tabrizi SJ; UCL Huntington's Disease Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK. .; UK Dementia Research Institute at UCL, UCL Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK. .
Andre R; UCL Huntington's Disease Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK. .
Pokaż więcej
Źródło :
Scientific reports [Sci Rep] 2020 Oct 14; Vol. 10 (1), pp. 17269. Date of Electronic Publication: 2020 Oct 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Huntingtin Protein/*immunology
Macrophages/*immunology
Cells, Cultured ; Cytokines/genetics ; Cytokines/immunology ; Humans ; Huntingtin Protein/genetics ; Phagocytosis
Czasopismo naukowe
Tytuł :
Osmolytes dynamically regulate mutant Huntingtin aggregation and CREB function in Huntington's disease cell models.
Autorzy :
Aravindan S; Department of Cell Biology and Neuroscience, Rutgers State University of New Jersey, Nelson Biology Laboratory, 604 Allison Road, Piscataway, NJ, 08854, USA.
Chen S; Department of Cell Biology and Neuroscience, Rutgers State University of New Jersey, Nelson Biology Laboratory, 604 Allison Road, Piscataway, NJ, 08854, USA.
Choudhry H; Department of Cell Biology and Neuroscience, Rutgers State University of New Jersey, Nelson Biology Laboratory, 604 Allison Road, Piscataway, NJ, 08854, USA.
Molfetta C; Department of Cell Biology and Neuroscience, Rutgers State University of New Jersey, Nelson Biology Laboratory, 604 Allison Road, Piscataway, NJ, 08854, USA.
Chen KY; Department of Chemistry and Chemical Biology, Rutgers State University of New Jersey, Nelson Biology Laboratory, 604 Allison Road, Piscataway, NJ, 08854, USA.
Liu AYC; Department of Cell Biology and Neuroscience, Rutgers State University of New Jersey, Nelson Biology Laboratory, 604 Allison Road, Piscataway, NJ, 08854, USA. .
Pokaż więcej
Źródło :
Scientific reports [Sci Rep] 2020 Sep 23; Vol. 10 (1), pp. 15511. Date of Electronic Publication: 2020 Sep 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cyclic AMP Response Element-Binding Protein/*metabolism
Huntingtin Protein/*metabolism
Huntington Disease/*metabolism
Animals ; Autophagy ; Gene Knockdown Techniques ; Glycerol/pharmacology ; HSC70 Heat-Shock Proteins/metabolism ; HSP70 Heat-Shock Proteins/metabolism ; Huntingtin Protein/genetics ; Mutation ; Osmolar Concentration ; PC12 Cells ; Protein Aggregation, Pathological/genetics ; Protein Aggregation, Pathological/metabolism ; Protein Folding ; Rats ; Sorbitol/pharmacology ; Sucrose/pharmacology ; Trehalose/pharmacology
Czasopismo naukowe
Tytuł :
Cell Type-Specific Transcriptomics Reveals that Mutant Huntingtin Leads to Mitochondrial RNA Release and Neuronal Innate Immune Activation.
Autorzy :
Lee H; Picower Institute for Learning and Memory, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Fenster RJ; Picower Institute for Learning and Memory, Cambridge, MA 02139, USA.
Pineda SS; Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA 02139, USA; MIT Computer Science and Artificial Intelligence Laboratory, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Gibbs WS; Ann Romney Center for Neurologic Disease, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Mohammadi S; MIT Computer Science and Artificial Intelligence Laboratory, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Davila-Velderrain J; MIT Computer Science and Artificial Intelligence Laboratory, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Garcia FJ; Department of Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, USA.
Therrien M; Picower Institute for Learning and Memory, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Novis HS; Ann Romney Center for Neurologic Disease, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Gao F; Picower Institute for Learning and Memory, Cambridge, MA 02139, USA; Bioinformatics Resource Center in the Beckman Institute at Caltech, Pasadena, CA 91125, USA.
Wilkinson H; CHDI Foundation/CHDI Management Inc., Princeton, NJ 08540, USA.
Vogt T; CHDI Foundation/CHDI Management Inc., Princeton, NJ 08540, USA.
Kellis M; Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA 02139, USA; MIT Computer Science and Artificial Intelligence Laboratory, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
LaVoie MJ; Ann Romney Center for Neurologic Disease, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Heiman M; Department of Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, USA; Picower Institute for Learning and Memory, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: .
Pokaż więcej
Źródło :
Neuron [Neuron] 2020 Sep 09; Vol. 107 (5), pp. 891-908.e8. Date of Electronic Publication: 2020 Jul 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Huntingtin Protein/*immunology
Huntington Disease/*immunology
Immunity, Innate/*immunology
Neurons/*immunology
RNA, Mitochondrial/*immunology
Animals ; Humans ; Huntingtin Protein/genetics ; Huntington Disease/genetics ; Huntington Disease/pathology ; Mice ; Mutation ; Neurons/pathology ; Transcriptome
Czasopismo naukowe
Tytuł :
Huntingtin gene CAG repeat size affects autism risk: Family-based and case-control association study.
Autorzy :
Piras IS; Neurogenomics Division, The Translational Genomics Research Institute, Phoenix, Arizona, USA.
Picinelli C; Mafalda Luce Center for Pervasive Developmental Disorders, Milan, Italy.
Iennaco R; Department of Biosciences, Università degli Studi di Milano, Milan, Italy.; Istituto Nazionale di Genetica Molecolare 'Romeo ed Enrica Invernizzi', Milan, Italy.
Baccarin M; Mafalda Luce Center for Pervasive Developmental Disorders, Milan, Italy.
Castronovo P; Mafalda Luce Center for Pervasive Developmental Disorders, Milan, Italy.
Tomaiuolo P; Interdepartmental Program 'Autism 0-90', 'Gaetano Martino' University Hospital, University of Messina, Messina, Italy.
Cucinotta F; Interdepartmental Program 'Autism 0-90', 'Gaetano Martino' University Hospital, University of Messina, Messina, Italy.
Ricciardello A; Interdepartmental Program 'Autism 0-90', 'Gaetano Martino' University Hospital, University of Messina, Messina, Italy.
Turriziani L; Interdepartmental Program 'Autism 0-90', 'Gaetano Martino' University Hospital, University of Messina, Messina, Italy.
Nanetti L; Unit of Medical Genetics and Neurogenetics, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Mariotti C; Unit of Medical Genetics and Neurogenetics, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Gellera C; Unit of Medical Genetics and Neurogenetics, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Lintas C; Unit of Child and Adolescent NeuroPsychiatry & Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio-Medico, Rome, Italy.
Sacco R; Unit of Child and Adolescent NeuroPsychiatry & Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio-Medico, Rome, Italy.
Zuccato C; Department of Biosciences, Università degli Studi di Milano, Milan, Italy.; Istituto Nazionale di Genetica Molecolare 'Romeo ed Enrica Invernizzi', Milan, Italy.
Cattaneo E; Department of Biosciences, Università degli Studi di Milano, Milan, Italy.; Istituto Nazionale di Genetica Molecolare 'Romeo ed Enrica Invernizzi', Milan, Italy.
Persico AM; Interdepartmental Program 'Autism 0-90', 'Gaetano Martino' University Hospital, University of Messina, Messina, Italy.
Pokaż więcej
Źródło :
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics [Am J Med Genet B Neuropsychiatr Genet] 2020 Sep; Vol. 183 (6), pp. 341-351. Date of Electronic Publication: 2020 Jul 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Autistic Disorder/*genetics
Huntingtin Protein/*genetics
Adult ; Alleles ; Autism Spectrum Disorder/genetics ; Autism Spectrum Disorder/metabolism ; Autistic Disorder/metabolism ; Brain ; Case-Control Studies ; Child ; Child, Preschool ; Family ; Female ; Gene Frequency/genetics ; Humans ; Huntingtin Protein/metabolism ; Huntington Disease/genetics ; Male ; Middle Aged ; Nerve Tissue Proteins/genetics ; Neurogenesis ; Penetrance ; Risk Factors ; Trinucleotide Repeat Expansion/genetics ; Trinucleotide Repeats/genetics
Czasopismo naukowe
Tytuł :
TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models.
Autorzy :
Hegde RN; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Chiki A; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Petricca L; Department of Neuroscience, IRBM Science Park, Rome, Italy.
Martufi P; Department of Neuroscience, IRBM Science Park, Rome, Italy.
Arbez N; Division of Neurobiology, Department of Psychiatry and Departments of Neurology, Neuroscience and Pharmacology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Mouchiroud L; Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Auwerx J; Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Landles C; Huntington's Disease Centre, Department of Neurodegenerative Disease and UK Dementia Research Institute at UCL, Queen Square Institute of Neurology, University College London, London, UK.
Bates GP; Huntington's Disease Centre, Department of Neurodegenerative Disease and UK Dementia Research Institute at UCL, Queen Square Institute of Neurology, University College London, London, UK.
Singh-Bains MK; Centre for Brain Research, Department of Anatomy and Medical Imaging, University of Auckland, Auckland, New Zealand.
Dragunow M; Centre for Brain Research, Department of Pharmacology and Clinical Pharmacology, University of Auckland, Auckland, New Zealand.
Curtis MA; Centre for Brain Research, Department of Anatomy and Medical Imaging, University of Auckland, Auckland, New Zealand.
Faull RL; Centre for Brain Research, Department of Anatomy and Medical Imaging, University of Auckland, Auckland, New Zealand.
Ross CA; Division of Neurobiology, Department of Psychiatry and Departments of Neurology, Neuroscience and Pharmacology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Caricasole A; Department of Neuroscience, IRBM Science Park, Rome, Italy.
Lashuel HA; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Pokaż więcej
Źródło :
The EMBO journal [EMBO J] 2020 Sep 01; Vol. 39 (17), pp. e104671. Date of Electronic Publication: 2020 Aug 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Mutation*
Protein Aggregates*
Caenorhabditis elegans/*metabolism
Huntingtin Protein/*metabolism
Huntington Disease/*metabolism
Protein-Serine-Threonine Kinases/*metabolism
Animals ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans Proteins/genetics ; Disease Models, Animal ; HEK293 Cells ; Humans ; Huntingtin Protein/genetics ; Huntington Disease/genetics ; Phosphorylation ; Protein-Serine-Threonine Kinases/genetics ; Rats
Czasopismo naukowe
Tytuł :
A role of cellular translation regulation associated with toxic Huntingtin protein.
Autorzy :
Joag H; National Centre for Cell Science, S. P. Pune University, Pune, India.; Max Planck Institute of Neurobiology, Martinsried, Germany.
Ghatpande V; National Centre for Cell Science, S. P. Pune University, Pune, India.
Desai M; National Centre for Cell Science, S. P. Pune University, Pune, India.
Sarkar M; National Centre for Cell Science, S. P. Pune University, Pune, India.
Raina A; National Centre for Cell Science, S. P. Pune University, Pune, India.
Shinde M; Institute of Bioinformatics and Biotechnology, S. P. Pune University, Pune, India.
Chitale R; Institute of Bioinformatics and Biotechnology, S. P. Pune University, Pune, India.
Deo A; Institute of Bioinformatics and Biotechnology, S. P. Pune University, Pune, India.
Bose T; Institute of Bioinformatics and Biotechnology, S. P. Pune University, Pune, India. .
Majumdar A; National Centre for Cell Science, S. P. Pune University, Pune, India. .
Pokaż więcej
Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2020 Sep; Vol. 77 (18), pp. 3657-3670. Date of Electronic Publication: 2019 Dec 03.
Typ publikacji :
Journal Article
MeSH Terms :
Protein Biosynthesis*
Huntingtin Protein/*metabolism
Animals ; Animals, Genetically Modified/metabolism ; Cells, Cultured ; Drosophila/metabolism ; Drosophila Proteins/antagonists & inhibitors ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Humans ; Huntingtin Protein/genetics ; Huntington Disease/metabolism ; Huntington Disease/pathology ; Neurons/cytology ; Neurons/metabolism ; Peptides/metabolism ; Polyribosomes/metabolism ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; RNA Interference ; RNA, Small Interfering/metabolism ; Transcription Factors/antagonists & inhibitors ; Transcription Factors/genetics ; Transcription Factors/metabolism ; mRNA Cleavage and Polyadenylation Factors/antagonists & inhibitors ; mRNA Cleavage and Polyadenylation Factors/genetics ; mRNA Cleavage and Polyadenylation Factors/metabolism
Czasopismo naukowe
Tytuł :
Huntington's disease alters human neurodevelopment.
Autorzy :
Barnat M; Univ. Grenoble Alpes, INSERM, U1216, Grenoble Institut Neurosciences, Grenoble, France.
Capizzi M; Univ. Grenoble Alpes, INSERM, U1216, Grenoble Institut Neurosciences, Grenoble, France.
Aparicio E; Univ. Grenoble Alpes, INSERM, U1216, Grenoble Institut Neurosciences, Grenoble, France.
Boluda S; Department of Neuropathology Raymond Escourolle, AP-HP, Pitié-Salpêtrière University Hospital, Paris, France.
Wennagel D; Univ. Grenoble Alpes, INSERM, U1216, Grenoble Institut Neurosciences, Grenoble, France.
Kacher R; Univ. Grenoble Alpes, INSERM, U1216, Grenoble Institut Neurosciences, Grenoble, France.
Kassem R; Univ. Grenoble Alpes, INSERM, U1216, Grenoble Institut Neurosciences, Grenoble, France.
Lenoir S; Univ. Grenoble Alpes, INSERM, U1216, Grenoble Institut Neurosciences, Grenoble, France.
Agasse F; Univ. Grenoble Alpes, INSERM, U1216, Grenoble Institut Neurosciences, Grenoble, France.
Braz BY; Univ. Grenoble Alpes, INSERM, U1216, Grenoble Institut Neurosciences, Grenoble, France.
Liu JP; Department of Neuroscience, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Ighil J; AP-HP, Sorbonne University, Service de Gynécologie Obstétrique, Pitié-Salpêtrière Hospital, Paris, France.
Tessier A; AP-HP, Unité d'Embryofoetopathologie, Necker Hospital, Paris, France.
Zeitlin SO; Department of Neuroscience, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Duyckaerts C; Department of Neuropathology Raymond Escourolle, AP-HP, Pitié-Salpêtrière University Hospital, Paris, France.
Dommergues M; AP-HP, Sorbonne University, Service de Gynécologie Obstétrique, Pitié-Salpêtrière Hospital, Paris, France.
Durr A; Sorbonne University, Paris Brain Institute, APHP, INSERM U1127, CNRS UMR7225, Pitié-Salpêtrière Hospital, Paris, France .
Humbert S; Univ. Grenoble Alpes, INSERM, U1216, Grenoble Institut Neurosciences, Grenoble, France. .
Pokaż więcej
Źródło :
Science (New York, N.Y.) [Science] 2020 Aug 14; Vol. 369 (6505), pp. 787-793. Date of Electronic Publication: 2020 Jul 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Huntingtin Protein/*metabolism
Huntington Disease/*metabolism
Nervous System/*embryology
Animals ; Cell Cycle ; Endosomes/metabolism ; Fetus ; Humans ; Huntingtin Protein/genetics ; Huntington Disease/genetics ; Mice ; Mice, Mutant Strains ; Mitosis ; Mutation ; Neuroepithelial Cells/metabolism ; Tight Junctions/metabolism ; Zonula Occludens-1 Protein/metabolism
Czasopismo naukowe
Tytuł :
Imaging Mutant Huntingtin Aggregates: Development of a Potential PET Ligand.
Autorzy :
Liu L; CHDI Management/CHDI Foundation, 6080 Center Drive, Suite 700, Los Angeles, California 90045, United States.
Prime ME; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K.
Lee MR; CHDI Management/CHDI Foundation, 6080 Center Drive, Suite 700, Los Angeles, California 90045, United States.
Khetarpal V; CHDI Management/CHDI Foundation, 6080 Center Drive, Suite 700, Los Angeles, California 90045, United States.
Brown CJ; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K.
Johnson PD; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K.
Miranda-Azpiazu P; Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Hospital, Karolinska Institutet, S-17176 Stockholm, Sweden.
Chen X; Albany Molecular Research, Inc., 1001 Main St., Buffalo, New York 14203, United States.
Clark-Frew D; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K.
Coe S; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K.
Davis R; Albany Molecular Research, Inc., 1001 Main St., Buffalo, New York 14203, United States.
Dickie A; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K.
Ebneth A; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K.
Esposito S; IRBM, IRBM Science Park S.p.A., Via Pontina Km 30, 600, 00071 Pomezia (RM), Italy.
Gadouleau E; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K.
Gai X; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K.
Galan S; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K.
Green S; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K.
Greenaway C; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K.
Giles P; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K.
Halldin C; Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Hospital, Karolinska Institutet, S-17176 Stockholm, Sweden.
Hayes S; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K.
Herbst T; CHDI Management/CHDI Foundation, 6080 Center Drive, Suite 700, Los Angeles, California 90045, United States.
Herrmann F; Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany.
Heßmann M; Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany.
Jia Z; Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Hospital, Karolinska Institutet, S-17176 Stockholm, Sweden.
Kiselyov A; CHDI Management/CHDI Foundation, 6080 Center Drive, Suite 700, Los Angeles, California 90045, United States.
Kotey A; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K.
Krulle T; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K.
Mangette JE; Albany Molecular Research, Inc., 1001 Main St., Buffalo, New York 14203, United States.
Marston RW; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K.
Menta S; IRBM, IRBM Science Park S.p.A., Via Pontina Km 30, 600, 00071 Pomezia (RM), Italy.
Mills MR; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K.
Monteagudo E; IRBM, IRBM Science Park S.p.A., Via Pontina Km 30, 600, 00071 Pomezia (RM), Italy.
Nag S; Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Hospital, Karolinska Institutet, S-17176 Stockholm, Sweden.
Nibbio M; IRBM, IRBM Science Park S.p.A., Via Pontina Km 30, 600, 00071 Pomezia (RM), Italy.
Orsatti L; IRBM, IRBM Science Park S.p.A., Via Pontina Km 30, 600, 00071 Pomezia (RM), Italy.
Schaertl S; Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany.
Scheich C; Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany.
Sproston J; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K.
Stepanov V; Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Hospital, Karolinska Institutet, S-17176 Stockholm, Sweden.
Svedberg M; Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Hospital, Karolinska Institutet, S-17176 Stockholm, Sweden.
Takano A; Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Hospital, Karolinska Institutet, S-17176 Stockholm, Sweden.
Taylor M; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K.
Thomas W; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K.
Toth M; Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Hospital, Karolinska Institutet, S-17176 Stockholm, Sweden.
Vaidya D; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K.
Vanräs K; Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Hospital, Karolinska Institutet, S-17176 Stockholm, Sweden.
Weddell D; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K.
Wigginton I; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K.
Wityak J; CHDI Management/CHDI Foundation, 6080 Center Drive, Suite 700, Los Angeles, California 90045, United States.
Mrzljak L; CHDI Management/CHDI Foundation, 6080 Center Drive, Suite 700, Los Angeles, California 90045, United States.
Munoz-Sanjuan I; CHDI Management/CHDI Foundation, 6080 Center Drive, Suite 700, Los Angeles, California 90045, United States.
Bard JA; CHDI Management/CHDI Foundation, 6080 Center Drive, Suite 700, Los Angeles, California 90045, United States.
Dominguez C; CHDI Management/CHDI Foundation, 6080 Center Drive, Suite 700, Los Angeles, California 90045, United States.
Pokaż więcej
Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Aug 13; Vol. 63 (15), pp. 8608-8633. Date of Electronic Publication: 2020 Jul 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Huntingtin Protein/*analysis
Huntington Disease/*diagnostic imaging
Positron-Emission Tomography/*methods
Protein Aggregation, Pathological/*diagnostic imaging
Animals ; Disease Models, Animal ; Dogs ; Female ; Humans ; Huntingtin Protein/genetics ; Huntington Disease/genetics ; Ligands ; Madin Darby Canine Kidney Cells ; Male ; Mice ; Mice, Inbred C57BL ; Mutation ; Peptides/genetics ; Protein Aggregation, Pathological/genetics ; Radiopharmaceuticals/analysis ; Rats, Sprague-Dawley
Czasopismo naukowe

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies