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Tytuł :
Transplantation of human dental pulp stem cells compensates for striatal atrophy and modulates neuro-inflammation in 3-nitropropionic acid rat model of Huntington's disease.
Autorzy :
Eskandari N; Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Boroujeni ME; Department of Human Molecular Genetics, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, Poznan, Poland.
Abdollahifar MA; Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Piryaei A; Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Khodagholi F; Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mirbehbahani SH; Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Siroosi S; Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Moghaddam MH; Anatomical Sciences Research Center Kashan, Kashan University of Medical Sciences, Kashan, Iran.
Aliaghaei A; Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: .
Sadeghi Y; Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Anatomy & Neuroscience, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, VIC, Australia. Electronic address: .
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Źródło :
Neuroscience research [Neurosci Res] 2021 Sep; Vol. 170, pp. 133-144. Date of Electronic Publication: 2020 Dec 22.
Typ publikacji :
Journal Article
MeSH Terms :
Huntington Disease*/chemically induced
Huntington Disease*/therapy
Animals ; Atrophy ; Dental Pulp ; Disease Models, Animal ; Humans ; Inflammation/chemically induced ; Nitro Compounds ; Propionates ; Rats ; Stem Cells
Czasopismo naukowe
Tytuł :
Clinical predictors and neural correlates for compromised swallowing safety in Huntington disease.
Autorzy :
Schumann-Werner B; Department of Neurology, Medical Faculty, RWTH Aachen University, Aachen, Germany.; Department of Neurology, Medical Faculty, Euregional Huntington Centre Aachen, RWTH Aachen University, Aachen, Germany.
Dogan I; Department of Neurology, Medical Faculty, RWTH Aachen University, Aachen, Germany.; Department of Neurology, Medical Faculty, Euregional Huntington Centre Aachen, RWTH Aachen University, Aachen, Germany.; JARA-BRAIN Institute Molecular Neuroscience and Neuroimaging, Forschungszentrum Jülich, Research Centre Jülich and RWTH Aachen University, Aachen, Germany.
Mirzazade S; Department of Neurology, Medical Faculty, RWTH Aachen University, Aachen, Germany.; JARA-BRAIN Institute Molecular Neuroscience and Neuroimaging, Forschungszentrum Jülich, Research Centre Jülich and RWTH Aachen University, Aachen, Germany.
Mall B; Department of Neurology, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Overbeck R; Department of Neurology, Medical Faculty, RWTH Aachen University, Aachen, Germany.; Department of Neurology, Medical Faculty, Euregional Huntington Centre Aachen, RWTH Aachen University, Aachen, Germany.
Honrath P; Department of Neurology, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Schulz JB; Department of Neurology, Medical Faculty, RWTH Aachen University, Aachen, Germany.; Department of Neurology, Medical Faculty, Euregional Huntington Centre Aachen, RWTH Aachen University, Aachen, Germany.; JARA-BRAIN Institute Molecular Neuroscience and Neuroimaging, Forschungszentrum Jülich, Research Centre Jülich and RWTH Aachen University, Aachen, Germany.; Section of Interdisciplinary Geriatrics, Department of Neurology, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Reetz K; Department of Neurology, Medical Faculty, RWTH Aachen University, Aachen, Germany.; Department of Neurology, Medical Faculty, Euregional Huntington Centre Aachen, RWTH Aachen University, Aachen, Germany.; JARA-BRAIN Institute Molecular Neuroscience and Neuroimaging, Forschungszentrum Jülich, Research Centre Jülich and RWTH Aachen University, Aachen, Germany.
Werner CJ; Department of Neurology, Medical Faculty, RWTH Aachen University, Aachen, Germany.; Department of Neurology, Medical Faculty, Euregional Huntington Centre Aachen, RWTH Aachen University, Aachen, Germany.; Section of Interdisciplinary Geriatrics, Department of Neurology, Medical Faculty, RWTH Aachen University, Aachen, Germany.
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Źródło :
European journal of neurology [Eur J Neurol] 2021 Sep; Vol. 28 (9), pp. 2855-2862. Date of Electronic Publication: 2021 Jun 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Deglutition Disorders*/diagnostic imaging
Deglutition Disorders*/etiology
Huntington Disease*/complications
Huntington Disease*/diagnostic imaging
Deglutition ; Female ; Gray Matter ; Humans ; Magnetic Resonance Imaging
Czasopismo naukowe
Tytuł :
Transglutaminase 6 Is Colocalized and Interacts with Mutant Huntingtin in Huntington Disease Rodent Animal Models.
Autorzy :
Schulze-Krebs A; Experimental Therapy, Preclinical Experimental Center, University Hospital Erlangen (UKEr), Friedrich-Alexander-University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
Canneva F; Experimental Therapy, Preclinical Experimental Center, University Hospital Erlangen (UKEr), Friedrich-Alexander-University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
Stemick J; Department of Molecular Neurology, University Hospital Erlangen (UKEr), Friedrich-Alexander-University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
Plank AC; Experimental Therapy, Preclinical Experimental Center, University Hospital Erlangen (UKEr), Friedrich-Alexander-University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
Harrer J; Experimental Therapy, Preclinical Experimental Center, University Hospital Erlangen (UKEr), Friedrich-Alexander-University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
Bates GP; Huntington's Disease Centre, Department of Neurodegenerative Disease and UK Dementia Research Institute at UCL, Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.
Aeschlimann D; Matrix Biology and Tissue Repair Research Unit, College of Biomedical and Life Sciences, School of Dentistry, Cardiff University, Cardiff CF14 4XY, UK.
Steffan JS; Institute of Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697, USA.; Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697, USA.
von Hörsten S; Experimental Therapy, Preclinical Experimental Center, University Hospital Erlangen (UKEr), Friedrich-Alexander-University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 18; Vol. 22 (16). Date of Electronic Publication: 2021 Aug 18.
Typ publikacji :
Journal Article
MeSH Terms :
Disease Models, Animal*
Mutation*
Huntingtin Protein/*metabolism
Huntington Disease/*pathology
Mutant Proteins/*metabolism
Neurons/*metabolism
Transglutaminases/*metabolism
Animals ; Huntingtin Protein/genetics ; Huntington Disease/genetics ; Huntington Disease/metabolism ; Mice ; Mice, Transgenic ; Mutant Proteins/genetics ; Rats ; Transglutaminases/genetics
Czasopismo naukowe
Tytuł :
Small-molecule suppression of calpastatin degradation reduces neuropathology in models of Huntington's disease.
Autorzy :
Hu D; Department of Physiology & Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Sun X; Department of Physiology & Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Magpusao A; Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Fedorov Y; Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Thompson M; Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Wang B; Proteomics Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Lundberg K; Proteomics Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Adams DJ; Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, OH, USA. .
Qi X; Department of Physiology & Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Sep 06; Vol. 12 (1), pp. 5305. Date of Electronic Publication: 2021 Sep 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium-Binding Proteins/*genetics
Dynamins/*genetics
Huntington Disease/*genetics
Mitochondria/*drug effects
Neuroprotective Agents/*pharmacology
Pyridines/*pharmacology
Pyrimidines/*pharmacology
Animals ; Calcium-Binding Proteins/metabolism ; Calpain/genetics ; Calpain/metabolism ; Corpus Striatum/drug effects ; Corpus Striatum/metabolism ; Corpus Striatum/pathology ; Disease Models, Animal ; Dynamins/metabolism ; Gene Expression Regulation ; Glycogen Synthase Kinase 3 beta/antagonists & inhibitors ; Glycogen Synthase Kinase 3 beta/genetics ; Glycogen Synthase Kinase 3 beta/metabolism ; Humans ; Huntington Disease/drug therapy ; Huntington Disease/metabolism ; Huntington Disease/pathology ; Injections, Intraperitoneal ; Male ; Mice ; Mitochondria/metabolism ; Mitochondria/pathology ; Neurons/drug effects ; Neurons/metabolism ; Neurons/pathology ; Primary Cell Culture ; Proteasome Endopeptidase Complex/metabolism ; Proteolysis ; Signal Transduction
Czasopismo naukowe
Tytuł :
The clinical, imaging and biological features of psychosis in Han Chinese patients with Huntington's disease.
Autorzy :
Li XY; Department of Neurology and Research Center of Neurology in Second Affiliated Hospital, and Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China.
Gao B; Department of Neurology and Research Center of Neurology in Second Affiliated Hospital, and Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China.
Xie JJ; Department of Neurology and Research Center of Neurology in Second Affiliated Hospital, and Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China.
Bao YF; Department of Neurology and Research Center of Neurology in Second Affiliated Hospital, and Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China.
Dong Y; Department of Neurology and Research Center of Neurology in Second Affiliated Hospital, and Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China; Department of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Wu ZY; Department of Neurology and Research Center of Neurology in Second Affiliated Hospital, and Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China; CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai, China. Electronic address: .
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Źródło :
Journal of psychiatric research [J Psychiatr Res] 2021 Sep; Vol. 141, pp. 333-338. Date of Electronic Publication: 2021 Jul 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Huntington Disease*/complications
Huntington Disease*/diagnostic imaging
Huntington Disease*/genetics
Neurodegenerative Diseases*
Psychotic Disorders*/diagnostic imaging
China ; Cross-Sectional Studies ; Disease Progression ; Female ; Humans ; Middle Aged
Czasopismo naukowe
Tytuł :
Gene targeting techniques for Huntington's disease.
Autorzy :
Fields E; Gemstone Honors Program, University of Maryland, College Park, MD 20742, United States.
Vaughan E; Gemstone Honors Program, University of Maryland, College Park, MD 20742, United States.
Tripu D; Gemstone Honors Program, University of Maryland, College Park, MD 20742, United States.
Lim I; Gemstone Honors Program, University of Maryland, College Park, MD 20742, United States.
Shrout K; Gemstone Honors Program, University of Maryland, College Park, MD 20742, United States.
Conway J; Gemstone Honors Program, University of Maryland, College Park, MD 20742, United States.
Salib N; Gemstone Honors Program, University of Maryland, College Park, MD 20742, United States.
Lee Y; Gemstone Honors Program, University of Maryland, College Park, MD 20742, United States.
Dhamsania A; Gemstone Honors Program, University of Maryland, College Park, MD 20742, United States.
Jacobsen M; Gemstone Honors Program, University of Maryland, College Park, MD 20742, United States.
Woo A; Gemstone Honors Program, University of Maryland, College Park, MD 20742, United States.
Xue H; Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, United States.
Cao K; Gemstone Honors Program, University of Maryland, College Park, MD 20742, United States; Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, United States. Electronic address: .
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Źródło :
Ageing research reviews [Ageing Res Rev] 2021 Sep; Vol. 70, pp. 101385. Date of Electronic Publication: 2021 Jun 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Huntington Disease*/genetics
Huntington Disease*/therapy
Alleles ; Gene Expression Regulation ; Gene Targeting ; Humans ; Huntingtin Protein/genetics ; Huntingtin Protein/metabolism
Czasopismo naukowe
Tytuł :
Health services utilization of Chinese patients with Huntington's disease: a cross-sectional study.
Autorzy :
Ke H; Department of Neurology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.; Department of Clinical Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Cao X; Chinese Huntington's Disease Association, Shanghai, China.
Song Y; Department of Biostatistics, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Cao L; Department of Neurology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China. .; Chinese Huntington's Disease Association, Shanghai, China. .; Department of Neurology, Institute of Neurology, Rui Jin Hospital & Rui Jin Hospital North, Shanghai Jiao Tong University School of Medicine, Shanghai, China. .
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Źródło :
BMC health services research [BMC Health Serv Res] 2021 Aug 12; Vol. 21 (1), pp. 806. Date of Electronic Publication: 2021 Aug 12.
Typ publikacji :
Journal Article
MeSH Terms :
Huntington Disease*/epidemiology
Huntington Disease*/therapy
Quality of Life*
China/epidemiology ; Cross-Sectional Studies ; Facilities and Services Utilization ; Humans
Czasopismo naukowe
Tytuł :
New Avenues for the Treatment of Huntington's Disease.
Autorzy :
Kim A; Island Medical Program and Faculty of Medicine, University of British Columbia, Victoria, BC V8P 5C2, Canada.
Lalonde K; Island Medical Program and Faculty of Medicine, University of British Columbia, Victoria, BC V8P 5C2, Canada.
Truesdell A; Division of Medical Sciences, University of Victoria, Victoria, BC V8P 5C2, Canada.; Schulich School of Medicine and Dentistry, Western University, London, ON N6A 5C1, Canada.
Gomes Welter P; Neuroscience Graduate Program, Federal University of Santa Catarina, Florianópolis 88040-900, Brazil.
Brocardo PS; Neuroscience Graduate Program, Federal University of Santa Catarina, Florianópolis 88040-900, Brazil.
Rosenstock TR; Institute of Cancer and Genomic Science, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.; Department of Pharmacology, University of São Paulo, São Paulo 05508-000, Brazil.
Gil-Mohapel J; Island Medical Program and Faculty of Medicine, University of British Columbia, Victoria, BC V8P 5C2, Canada.; Division of Medical Sciences, University of Victoria, Victoria, BC V8P 5C2, Canada.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 04; Vol. 22 (16). Date of Electronic Publication: 2021 Aug 04.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Huntington Disease/*therapy
Animals ; Autophagy ; Clinical Trials as Topic ; Disease Management ; Disease Models, Animal ; Humans ; Huntington Disease/genetics ; Huntington Disease/pathology ; Huntington Disease/physiopathology
Czasopismo naukowe
Tytuł :
Demethyleneberberine: A possible treatment for Huntington's disease.
Autorzy :
Gupta S; Chitkara College of Pharmacy, Chitkara University, Punjab 140401, India.
Khan A; Chitkara College of Pharmacy, Chitkara University, Punjab 140401, India.
Vishwas S; School of Pharmaceutical Sciences, Lovely Professional University, Punjab 144411, India.
Gulati M; School of Pharmaceutical Sciences, Lovely Professional University, Punjab 144411, India.
Gurjeet Singh T; Chitkara College of Pharmacy, Chitkara University, Punjab 140401, India.
Dua K; Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Australia.
Kumar Singh S; School of Pharmaceutical Sciences, Lovely Professional University, Punjab 144411, India. Electronic address: .
Najda A; Laboratory of Quality of Vegetables and Medicinal Plants, Department of Vegetable Crops and Medicinal Plants, University of Life Sciences in Lublin, 15 Akademicka Street, 20-950 Lublin, Poland. Electronic address: .
Sayed AA; Zoology Department, Faculty of Science, Cairo University, Giza 12613, Egypt.
Almeer R; Department of Zoology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
Abdel-Daim MM; Pharmacology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt. Electronic address: .
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Źródło :
Medical hypotheses [Med Hypotheses] 2021 Aug; Vol. 153, pp. 110639. Date of Electronic Publication: 2021 Jun 29.
Typ publikacji :
Journal Article
MeSH Terms :
Berberine*/analogs & derivatives
Berberine*/therapeutic use
Huntington Disease*/drug therapy
Neurodegenerative Diseases*
Humans ; Oxidative Stress
Czasopismo naukowe
Tytuł :
Huntington's Chorea-a Rare Neurodegenerative Autosomal Dominant Disease: Insight into Molecular Genetics, Prognosis and Diagnosis.
Autorzy :
Talukder P; Department of Biotechnology, University of Engineering and Management, Kolkata, University Area, Plot, Street Number 03, Action Area III, B/5, Newtown, Kolkata, West Bengal, 700156, India. .
Jana A; Department of Biotechnology, University of Engineering and Management, Kolkata, University Area, Plot, Street Number 03, Action Area III, B/5, Newtown, Kolkata, West Bengal, 700156, India.
Dhar S; Department of Biotechnology, University of Engineering and Management, Kolkata, University Area, Plot, Street Number 03, Action Area III, B/5, Newtown, Kolkata, West Bengal, 700156, India.
Ghosh S; Department of Biotechnology, University of Engineering and Management, Kolkata, University Area, Plot, Street Number 03, Action Area III, B/5, Newtown, Kolkata, West Bengal, 700156, India.
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Źródło :
Applied biochemistry and biotechnology [Appl Biochem Biotechnol] 2021 Aug; Vol. 193 (8), pp. 2634-2648. Date of Electronic Publication: 2021 Jul 07.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Genetic Testing*
Huntingtin Protein*/genetics
Huntingtin Protein*/metabolism
Huntington Disease*/diagnosis
Huntington Disease*/genetics
Huntington Disease*/metabolism
Protein Biosynthesis*
Transcription, Genetic*
Trinucleotide Repeat Expansion*
Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Humans
Czasopismo naukowe
Tytuł :
Isoform-Specific Reduction of the Basic Helix-Loop-Helix Transcription Factor TCF4 Levels in Huntington's Disease.
Autorzy :
Nurm K; Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn 12618, Estonia.
Sepp M; Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn 12618, Estonia.
Castany-Pladevall C; Departament de Biomedicina, Facultat de Medicina i Ciències de la Salut, Institut de Neurociències, Universitat de Barcelona, Barcelona, Catalonia 08036, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia 08036, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, 28031, Spain.
Creus-Muncunill J; Departament de Biomedicina, Facultat de Medicina i Ciències de la Salut, Institut de Neurociències, Universitat de Barcelona, Barcelona, Catalonia 08036, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia 08036, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, 28031, Spain.
Tuvikene J; Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn 12618, Estonia.; Protobios LLC, Tallinn 12618, Estonia.
Sirp A; Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn 12618, Estonia.
Vihma H; Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn 12618, Estonia.
Blake DJ; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff CF24 4HQ, United Kingdom.
Perez-Navarro E; Departament de Biomedicina, Facultat de Medicina i Ciències de la Salut, Institut de Neurociències, Universitat de Barcelona, Barcelona, Catalonia 08036, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia 08036, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, 28031, Spain.
Timmusk T; Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn 12618, Estonia .; Protobios LLC, Tallinn 12618, Estonia.
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Źródło :
ENeuro [eNeuro] 2021 Oct 14; Vol. 8 (5). Date of Electronic Publication: 2021 Oct 14 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Huntington Disease*/genetics
Adult ; Animals ; Disease Models, Animal ; Hippocampus ; Humans ; Male ; Mice ; Mice, Transgenic ; Neurons ; Protein Isoforms ; Transcription Factor 4/genetics
Czasopismo naukowe
Tytuł :
Tracking Huntington's Disease Progression Using Motor, Functional, Cognitive, and Imaging Markers.
Autorzy :
Abeyasinghe PM; School of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash University, Melbourne, Victoria, Australia.
Long JD; Department of Psychiatry, Carver Collage of Medicine, The University of Iowa, Iowa City, Iowa, USA.; Department of Biostatistics, College of Public Health, The University of Iowa, Iowa City, Iowa, USA.
Razi A; School of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash University, Melbourne, Victoria, Australia.; Monash Biomedical Imaging, Monash University, Clayton, Victoria, Australia.; Wellcome Centre for Human Neuroimaging, UCL, London, United Kingdom.
Pustina D; CHDI Management/CHDI Foundation, Princeton, New Jersey, USA.
Paulsen JS; Department of Neurology, University of Wisconsin, Madison, Wisconsin, USA.
Tabrizi SJ; UCL Department of Neurodegenerative Disease and Huntington's Disease Centre, UCL Queen Square Institute of Neurology, Dementia Research Institute at UCL, London, United Kingdom.
Poudel GR; Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Victoria, Australia.
Georgiou-Karistianis N; School of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash University, Melbourne, Victoria, Australia.
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Źródło :
Movement disorders : official journal of the Movement Disorder Society [Mov Disord] 2021 Oct; Vol. 36 (10), pp. 2282-2292. Date of Electronic Publication: 2021 May 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Huntington Disease*/diagnostic imaging
Biomarkers ; Cognition ; Disease Progression ; Humans ; Longitudinal Studies ; Magnetic Resonance Imaging
Czasopismo naukowe
Tytuł :
Late-onset Huntington's disease associated with CAG repeat lengths of 30 and 31.
Autorzy :
Stoker TB; John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, E.D. Adrian Building, Forvie Site, Robinson Way, Cambridge, CB2 0PY, UK. .
Holden ST; Department of Clinical Genetics, East Anglian Medical Genetics Service, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.
Barker RA; John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, E.D. Adrian Building, Forvie Site, Robinson Way, Cambridge, CB2 0PY, UK.; Wellcome Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, UK.
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Źródło :
Journal of neurology [J Neurol] 2021 Oct; Vol. 268 (10), pp. 3916-3919. Date of Electronic Publication: 2021 Jun 17.
Typ publikacji :
Letter
MeSH Terms :
Huntington Disease*/genetics
Humans ; Huntingtin Protein/genetics ; Trinucleotide Repeat Expansion/genetics ; Trinucleotide Repeats/genetics
Opinia redakcyjna
Tytuł :
Macromolecular crowding in solution alters huntingtin interaction and aggregation at interfaces.
Autorzy :
Groover SE; The C. Eugene Bennett Department of Chemistry, West Virginia University, 217 Clark Hall, Morgantown, WV 26506, United States.
Adegbuyiro A; The C. Eugene Bennett Department of Chemistry, West Virginia University, 217 Clark Hall, Morgantown, WV 26506, United States.
Fan CK; The C. Eugene Bennett Department of Chemistry, West Virginia University, 217 Clark Hall, Morgantown, WV 26506, United States.
Hodges BL; The C. Eugene Bennett Department of Chemistry, West Virginia University, 217 Clark Hall, Morgantown, WV 26506, United States.
Beasley M; The C. Eugene Bennett Department of Chemistry, West Virginia University, 217 Clark Hall, Morgantown, WV 26506, United States.
Taylor K; The C. Eugene Bennett Department of Chemistry, West Virginia University, 217 Clark Hall, Morgantown, WV 26506, United States.
Stonebraker AR; The C. Eugene Bennett Department of Chemistry, West Virginia University, 217 Clark Hall, Morgantown, WV 26506, United States.
Siriwardhana C; The C. Eugene Bennett Department of Chemistry, West Virginia University, 217 Clark Hall, Morgantown, WV 26506, United States.
Legleiter J; The C. Eugene Bennett Department of Chemistry, West Virginia University, 217 Clark Hall, Morgantown, WV 26506, United States; Rockefeller Neurosciences Institutes, West Virginia University, 1 Medical Center Dr., P.O. Box 9303, Morgantown, WV 26505, United States; Department of Neuroscience, West Virginia University, 1 Medical Center Dr., P.O. Box 9303, Morgantown, WV 26505, United States. Electronic address: .
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Źródło :
Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2021 Oct; Vol. 206, pp. 111969. Date of Electronic Publication: 2021 Jul 07.
Typ publikacji :
Journal Article
MeSH Terms :
Huntington Disease*
Neurodegenerative Diseases*
Humans ; Huntingtin Protein/genetics ; Lipid Bilayers ; Protein Aggregates
Czasopismo naukowe
Tytuł :
Caenorhabditis elegans as a Model System for Discovering Bioactive Compounds against Polyglutamine-mediated Neurotoxicity.
Autorzy :
Wang Q; Institute for Food Nutrition and Human Health, School of Food Science and Engineering, South China University of Technology.
Zhang J; School of Bioscience and Bioengineering, Hebei University of Economics and Business.
Jiang Y; Institute for Food Nutrition and Human Health, School of Food Science and Engineering, South China University of Technology; Perfect Life & Health Institute.
Xiao Y; Institute for Food Nutrition and Human Health, School of Food Science and Engineering, South China University of Technology.
Li X; Perfect Life & Health Institute.
Mao X; Perfect Life & Health Institute.
Huang Z; Institute for Food Nutrition and Human Health, School of Food Science and Engineering, South China University of Technology; .
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Źródło :
Journal of visualized experiments : JoVE [J Vis Exp] 2021 Sep 21 (175). Date of Electronic Publication: 2021 Sep 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Video-Audio Media
MeSH Terms :
Caenorhabditis elegans*/genetics
Huntington Disease*/genetics
Animals ; Huntingtin Protein/genetics ; Peptides
Czasopismo naukowe
Tytuł :
Exploring the Potential of Reinforcement Learning as a Clinical Biomarker in Premanifest Huntington's Disease.
Autorzy :
Voon V; Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom; Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China. Electronic address: .
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Źródło :
Biological psychiatry. Cognitive neuroscience and neuroimaging [Biol Psychiatry Cogn Neurosci Neuroimaging] 2021 Sep; Vol. 6 (9), pp. 854-855.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Comment
MeSH Terms :
Huntington Disease*/diagnosis
Biomarkers ; Disease Progression ; Humans
Czasopismo naukowe
Tytuł :
Aberrant Striatal Value Representation in Huntington's Disease Gene Carriers 25 Years Before Onset.
Autorzy :
Nair A; Huntington's Disease Centre, University College London Queen Square Institute of Neurology, University College London, London, United Kingdom; Max Planck University College London Centre for Computational Psychiatry and Ageing Research, University College London Queen Square Institute of Neurology, University College London, London, United Kingdom.
Johnson EB; Huntington's Disease Centre, University College London Queen Square Institute of Neurology, University College London, London, United Kingdom.
Gregory S; Huntington's Disease Centre, University College London Queen Square Institute of Neurology, University College London, London, United Kingdom.
Osborne-Crowley K; Huntington's Disease Centre, University College London Queen Square Institute of Neurology, University College London, London, United Kingdom.
Zeun P; Huntington's Disease Centre, University College London Queen Square Institute of Neurology, University College London, London, United Kingdom.
Scahill RI; Huntington's Disease Centre, University College London Queen Square Institute of Neurology, University College London, London, United Kingdom.
Lowe J; Huntington's Disease Centre, University College London Queen Square Institute of Neurology, University College London, London, United Kingdom.
Papoutsi M; Huntington's Disease Centre, University College London Queen Square Institute of Neurology, University College London, London, United Kingdom.
Palminteri S; Laboratoire de Neurosciences Cognitives et Computationnelles, Institut National de la Santé et de la Recherche Médicale, Paris, France; Département d'Etudes Cognitives, Ecole Normale Supérieure, Paris, France; Université de Paris Sciences et Lettres, Paris, France.
Rutledge RB; Max Planck University College London Centre for Computational Psychiatry and Ageing Research, University College London Queen Square Institute of Neurology, University College London, London, United Kingdom; University College London Institute of Cognitive Neuroscience, University College London Queen Square Institute of Neurology, University College London, London, United Kingdom.
Rees G; University College London Institute of Cognitive Neuroscience, University College London Queen Square Institute of Neurology, University College London, London, United Kingdom.
Tabrizi SJ; Huntington's Disease Centre, University College London Queen Square Institute of Neurology, University College London, London, United Kingdom; Wellcome Centre for Human Neuroimaging, University College London Queen Square Institute of Neurology, University College London, London, United Kingdom. Electronic address: .
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Źródło :
Biological psychiatry. Cognitive neuroscience and neuroimaging [Biol Psychiatry Cogn Neurosci Neuroimaging] 2021 Sep; Vol. 6 (9), pp. 910-918. Date of Electronic Publication: 2021 Jan 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Huntington Disease*/genetics
Corpus Striatum ; Humans ; Magnetic Resonance Imaging ; Reward
Czasopismo naukowe
Tytuł :
Huntington's disease among immigrant groups and Swedish-born individuals: a cohort study of all adults 18 years of age and older in Sweden.
Autorzy :
Wändell P; Division of Family Medicine and Primary Care, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden. .
Fredrikson S; Division of Neurology, Department of Clinical Neuroscience, Karolinska Institutet Huddinge, Stockholm, Sweden.
Carlsson AC; Division of Family Medicine and Primary Care, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden.; Academic Primary Health Care Centre, Stockholm Region, Stockholm, Sweden.
Li X; Center for Primary Health Care Research, Lund University, Malmö, Sweden.
Sundquist J; Center for Primary Health Care Research, Lund University, Malmö, Sweden.; Department of Family Medicine and Community Health, Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Community-based Healthcare Research and Education (CoHRE), Department of Functional Pathology, School of Medicine, Shimane University, Matsue, Japan.
Sundquist K; Center for Primary Health Care Research, Lund University, Malmö, Sweden.; Department of Family Medicine and Community Health, Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Community-based Healthcare Research and Education (CoHRE), Department of Functional Pathology, School of Medicine, Shimane University, Matsue, Japan.
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Źródło :
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology [Neurol Sci] 2021 Sep; Vol. 42 (9), pp. 3851-3856. Date of Electronic Publication: 2021 Jan 30.
Typ publikacji :
Journal Article
MeSH Terms :
Emigrants and Immigrants*
Huntington Disease*/epidemiology
Adolescent ; Adult ; Aged, 80 and over ; Cohort Studies ; Female ; Humans ; Incidence ; Male ; Risk Factors ; Sweden/epidemiology
Czasopismo naukowe
Tytuł :
Greater time in bed and less physical activity associate with poorer cognitive functioning performance in Huntington's disease.
Autorzy :
McLaren B; School of Psychological Sciences, Turner Institute for Brain and Mental Health, Monash University.
Drummond SPA; School of Psychological Sciences, Turner Institute for Brain and Mental Health, Monash University.
Glikmann-Johnston Y; School of Psychological Sciences, Turner Institute for Brain and Mental Health, Monash University.
Loy C; Brain and Mind Centre, University of Sydney.
Bellgrove MA; School of Psychological Sciences, Turner Institute for Brain and Mental Health, Monash University.
Stout JC; School of Psychological Sciences, Turner Institute for Brain and Mental Health, Monash University.
Andrews SC; School of Psychological Sciences, Turner Institute for Brain and Mental Health, Monash University.
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Źródło :
Neuropsychology [Neuropsychology] 2021 Sep; Vol. 35 (6), pp. 656-667. Date of Electronic Publication: 2021 Jul 22.
Typ publikacji :
Journal Article
MeSH Terms :
Huntington Disease*/complications
Cognition ; Exercise ; Humans ; Memory, Short-Term ; Neuropsychological Tests
Czasopismo naukowe
Tytuł :
Huntington's disease: lessons from prion disorders.
Autorzy :
Alpaugh M; Département de Psychiatrie & Neurosciences, Faculté de Médecine, Université Laval, Québec, QC, G1V 0A6, Canada. .; Centre de Recherche du CHU de Québec, Axe Neuroscience, T2-50, 2705 boulevard Laurier, Québec, QC, G1V 4G2, Canada. .
Cicchetti F; Département de Psychiatrie & Neurosciences, Faculté de Médecine, Université Laval, Québec, QC, G1V 0A6, Canada. .; Centre de Recherche du CHU de Québec, Axe Neuroscience, T2-50, 2705 boulevard Laurier, Québec, QC, G1V 4G2, Canada. .
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Źródło :
Journal of neurology [J Neurol] 2021 Sep; Vol. 268 (9), pp. 3493-3504. Date of Electronic Publication: 2021 Feb 24.
Typ publikacji :
Journal Article
MeSH Terms :
Huntington Disease*/genetics
Neurodegenerative Diseases*
Prion Diseases*
Prions*/genetics
Humans ; Prion Proteins/genetics
Czasopismo naukowe

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