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Tytuł:
Epigallocatechin-3-gallate Enhances Cognitive and Memory Performance and Protects Against Brain Injury in Methionine-induced Hyperhomocysteinemia Through Interdependent Molecular Pathways.
Autorzy:
Mostafa MD; Zoology Department, Faculty of Science, Mansoura University, Mansoura, Egypt.
ElKomy MA; Zoology Department, Faculty of Science, Mansoura University, Mansoura, Egypt.
Othman AI; Zoology Department, Faculty of Science, Mansoura University, Mansoura, Egypt.
Amer ME; Zoology Department, Faculty of Science, Mansoura University, Mansoura, Egypt.
El-Missiry MA; Zoology Department, Faculty of Science, Mansoura University, Mansoura, Egypt. .
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Źródło:
Neurotoxicity research [Neurotox Res] 2022 Dec; Vol. 40 (6), pp. 2103-2116. Date of Electronic Publication: 2022 Nov 17.
Typ publikacji:
Journal Article
MeSH Terms:
Hyperhomocysteinemia*/chemically induced
Hyperhomocysteinemia*/complications
Hyperhomocysteinemia*/drug therapy
Catechin*/pharmacology
Catechin*/therapeutic use
Brain Injuries*
Mice ; Male ; Animals ; Methionine/pharmacology ; Oxidative Stress ; Cognition ; Apoptosis Regulatory Proteins ; Racemethionine/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Protective Effects of Acetazolamide Against Homocysteine-Induced Blood-Brain-Barrier Disruption by Regulating the Activation of the Wnt/β-Catenin Signaling Pathway.
Autorzy:
Li C; Department of Neurology, Guangzhou Eighth People's Hospital, Guangzhou Medical University, No.8 Huaying Road, Guangzhou, 510440, Guangdong, China. .
Zhang B; Department of Neurology, Guangzhou Eighth People's Hospital, Guangzhou Medical University, No.8 Huaying Road, Guangzhou, 510440, Guangdong, China.
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Źródło:
Neurotoxicity research [Neurotox Res] 2022 Oct; Vol. 40 (5), pp. 1261-1271. Date of Electronic Publication: 2022 Aug 03.
Typ publikacji:
Journal Article
MeSH Terms:
Brain Diseases*/metabolism
Hyperhomocysteinemia*/chemically induced
Hyperhomocysteinemia*/drug therapy
Hyperhomocysteinemia*/metabolism
Neuroprotective Agents*/metabolism
Neuroprotective Agents*/pharmacology
Acetazolamide/metabolism ; Acetazolamide/pharmacology ; Animals ; Blood-Brain Barrier ; Carbonic Anhydrase Inhibitors/metabolism ; Carbonic Anhydrase Inhibitors/pharmacology ; Claudin-5/metabolism ; Claudin-5/pharmacology ; Endothelial Cells/metabolism ; Homocysteine/metabolism ; Matrix Metalloproteinase 2/metabolism ; Matrix Metalloproteinase 9/metabolism ; Mice ; Occludin/metabolism ; Occludin/pharmacology ; Rats ; Wnt Signaling Pathway/physiology ; beta Catenin/metabolism ; beta Catenin/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Hyperhomocysteinemia-related serum metabolome alterations not normalized by short-term folic acid treatment.
Autorzy:
Kumar AA; Cardiovascular Diseases & Diabetes Biology, Rajiv Gandhi Centre for Biotechnology, Poojappura, Thiruvananthapuram, Kerala, 695014, India.
Anusree VR; Cardiovascular Diseases & Diabetes Biology, Rajiv Gandhi Centre for Biotechnology, Poojappura, Thiruvananthapuram, Kerala, 695014, India.
Satheesh G; Cardiovascular Diseases & Diabetes Biology, Rajiv Gandhi Centre for Biotechnology, Poojappura, Thiruvananthapuram, Kerala, 695014, India.
Vijayakumar G; Medical Trust Hospital and Diabetes Care Centre, Kulanada, Pathanamthitta, Kerala, India.
Chandran M; Mass Spectrometry and Proteomics Core Facility, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, 695014, India.
Simon L; Medical Trust Hospital and Diabetes Care Centre, Kulanada, Pathanamthitta, Kerala, India.
Lakshmi S; Division of Cancer Research, Regional Cancer Centre, Thiruvananthapuram, Kerala, India.
Pillai MR; Cancer Research Program, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, 695014, India.
Jaleel A; Cardiovascular Diseases & Diabetes Biology, Rajiv Gandhi Centre for Biotechnology, Poojappura, Thiruvananthapuram, Kerala, 695014, India. .; Mass Spectrometry and Proteomics Core Facility, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, 695014, India. .
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Źródło:
Metabolomics : Official journal of the Metabolomic Society [Metabolomics] 2021 May 09; Vol. 17 (5), pp. 47. Date of Electronic Publication: 2021 May 09.
Typ publikacji:
Journal Article
MeSH Terms:
Hyperhomocysteinemia*/drug therapy
Adolescent ; Adult ; Folic Acid ; Folic Acid Deficiency/drug therapy ; Homocysteine ; Humans ; Metabolome ; Vitamin B 12 ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Maternal Hyperhomocysteinemia Induces Neuroinflammation and Neuronal Death in the Rat Offspring Cortex.
Autorzy:
Shcherbitskaia AD; D.O. Ott Institute of Obstetrics, Gynecology, and Reproductology, St. Petersburg, Russia. .; I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, St. Petersburg, Russia. .
Vasilev DS; I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, St. Petersburg, Russia.
Milyutina YP; D.O. Ott Institute of Obstetrics, Gynecology, and Reproductology, St. Petersburg, Russia.
Tumanova NL; I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, St. Petersburg, Russia.
Zalozniaia IV; D.O. Ott Institute of Obstetrics, Gynecology, and Reproductology, St. Petersburg, Russia.
Kerkeshko GO; Saint Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia.
Arutjunyan AV; D.O. Ott Institute of Obstetrics, Gynecology, and Reproductology, St. Petersburg, Russia.
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Źródło:
Neurotoxicity research [Neurotox Res] 2020 Aug; Vol. 38 (2), pp. 408-420. Date of Electronic Publication: 2020 Jun 05.
Typ publikacji:
Journal Article
MeSH Terms:
Cerebral Cortex/*metabolism
Hyperhomocysteinemia/*metabolism
Inflammation/*metabolism
Neurons/*metabolism
Pregnancy Complications/*metabolism
Animals ; Animals, Newborn ; Apoptosis ; Brain/metabolism ; Brain/pathology ; Caspase 3/metabolism ; Cerebral Cortex/pathology ; Disease Models, Animal ; Female ; Hyperhomocysteinemia/chemically induced ; Inflammation/pathology ; Interleukin-1beta/metabolism ; Interleukin-6/metabolism ; Methionine/toxicity ; Neuroglia/metabolism ; Neuroglia/pathology ; Neurons/pathology ; Pregnancy ; Pregnancy Complications/chemically induced ; Rats ; Tumor Necrosis Factor-alpha/metabolism ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Chronic Mild Hyperhomocysteinemia Alters Inflammatory and Oxidative/Nitrative Status and Causes Protein/DNA Damage, as well as Ultrastructural Changes in Cerebral Cortex: Is Acetylsalicylic Acid Neuroprotective?
Autorzy:
de S Moreira D; Programa de Pós-Graduação em Ciências Biológicas: Bioquímica, ICBS, UFRGS, Porto Alegre, RS, Brazil.; Laboratório de Neuroproteção e Doenças Neurometabólicas, Departamento de Bioquímica, ICBS, UFRGS, Porto Alegre, RS, Brazil.
Figueiró PW; Programa de Pós-Graduação em Ciências Biológicas: Bioquímica, ICBS, UFRGS, Porto Alegre, RS, Brazil.; Laboratório de Neuroproteção e Doenças Neurometabólicas, Departamento de Bioquímica, ICBS, UFRGS, Porto Alegre, RS, Brazil.
Siebert C; Programa de Pós-Graduação em Ciências Biológicas: Bioquímica, ICBS, UFRGS, Porto Alegre, RS, Brazil.; Laboratório de Neuroproteção e Doenças Neurometabólicas, Departamento de Bioquímica, ICBS, UFRGS, Porto Alegre, RS, Brazil.
Prezzi CA; Laboratório de Neuroproteção e Doenças Neurometabólicas, Departamento de Bioquímica, ICBS, UFRGS, Porto Alegre, RS, Brazil.
Rohden F; Programa de Pós-Graduação em Ciências Biológicas: Bioquímica, ICBS, UFRGS, Porto Alegre, RS, Brazil.
Guma FCR; Programa de Pós-Graduação em Ciências Biológicas: Bioquímica, ICBS, UFRGS, Porto Alegre, RS, Brazil.; Departamento de Bioquímica, ICBS, UFRGS, Rua Ramiro Barcelos, 2600-Anexo, Porto Alegre, RS, 90035-003, Brazil.
Manfredini V; Laboratório de Hematologia e Citologia Clínica, Universidade Federal do Pampa, BR 472, Km 592, Caixa Postal 118, Uruguaiana, RS, 97508-000, Brazil.
Wyse ATS; Programa de Pós-Graduação em Ciências Biológicas: Bioquímica, ICBS, UFRGS, Porto Alegre, RS, Brazil. .; Laboratório de Neuroproteção e Doenças Neurometabólicas, Departamento de Bioquímica, ICBS, UFRGS, Porto Alegre, RS, Brazil. .; Departamento de Bioquímica, ICBS, UFRGS, Rua Ramiro Barcelos, 2600-Anexo, Porto Alegre, RS, 90035-003, Brazil. .
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Źródło:
Neurotoxicity research [Neurotox Res] 2018 Apr; Vol. 33 (3), pp. 580-592. Date of Electronic Publication: 2017 Dec 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Acetylcholinesterase/*metabolism
Cerebral Cortex/*pathology
Cerebral Cortex/*ultrastructure
Cytokines/*metabolism
Hyperhomocysteinemia/*complications
Nitrites/*metabolism
Animals ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Aspirin/pharmacology ; Catalase/metabolism ; Comet Assay ; DNA Damage/drug effects ; Dendritic Spines/drug effects ; Dendritic Spines/ultrastructure ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Homocysteine/toxicity ; Hyperhomocysteinemia/chemically induced ; Hyperhomocysteinemia/pathology ; Male ; Oxidative Stress ; Rats ; Rats, Wistar ; Superoxide Dismutase/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Opicapone Protects Against Hyperhomocysteinemia-Induced Increase in Blood-Brain Barrier Permeability.
Autorzy:
Wang J; Department of Neurology, Ya'an Peoples Hospital, Ya'an, 625000, Sichuan, China.
Zheng B; Department of Neurology, Ya'an Peoples Hospital, Ya'an, 625000, Sichuan, China.
Yang S; Department of Neurology, The Affiliated Hospital of University of Electronic Science and Technology, Sichuan Provincial People's Hospital, Chengdu, 610000, Sichuan, China.
Zheng H; Department of Neurology, Chengdu First People's Hospital, Chengdu, 610000, Sichuan, China. .
Wang J; Department of Neurology, The Affiliated Hospital of University of Electronic Science and Technology, Sichuan Provincial People's Hospital, Chengdu, 610000, Sichuan, China. drwang_.
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Źródło:
Neurotoxicity research [Neurotox Res] 2021 Dec; Vol. 39 (6), pp. 2018-2028. Date of Electronic Publication: 2021 Oct 28.
Typ publikacji:
Journal Article
MeSH Terms:
Blood-Brain Barrier/*drug effects
Hyperhomocysteinemia/*complications
Neuroprotective Agents/*therapeutic use
Oxadiazoles/*therapeutic use
Animals ; Blotting, Western ; Cell Membrane Permeability/drug effects ; Enzyme-Linked Immunosorbent Assay ; Male ; Mice ; Mice, Inbred C57BL ; Neuroprotective Agents/pharmacology ; Oxadiazoles/pharmacology ; Real-Time Polymerase Chain Reaction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Severe Hyperhomocysteinemia Decreases Creatine Kinase Activity and Causes Memory Impairment: Neuroprotective Role of Creatine.
Autorzy:
Kolling J; Department of Biochemistry, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Longoni A; Department of Biochemistry, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Siebert C; Department of Biochemistry, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Dos Santos TM; Department of Biochemistry, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Marques EP; Department of Biochemistry, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Carletti J; Department of Morphological Sciences, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Pereira LO; Department of Morphological Sciences, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Wyse ATS; Department of Biochemistry, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. .; Departamento de Bioquímica, Instituto das Ciências da Saúde (ICBS), Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600 anexo, Porto Alegre, RS, 90035-003, Brazil. .
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Źródło:
Neurotoxicity research [Neurotox Res] 2017 Nov; Vol. 32 (4), pp. 585-593. Date of Electronic Publication: 2017 Jun 27.
Typ publikacji:
Journal Article
MeSH Terms:
Creatine/*pharmacology
Creatine Kinase/*drug effects
Hippocampus/*drug effects
Hyperhomocysteinemia/*drug therapy
Memory/*drug effects
Animals ; Female ; Homeostasis/drug effects ; Hyperhomocysteinemia/chemically induced ; Male ; Memory Disorders/prevention & control ; Neuroprotection/drug effects ; Phosphorylation ; Rats, Wistar
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Homocysteine and Gliotoxicity.
Autorzy:
Wyse ATS; Programa de Pós-Graduação em Ciências Biológicas - Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. .; Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. .
Bobermin LD; Programa de Pós-Graduação em Ciências Biológicas - Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Dos Santos TM; Programa de Pós-Graduação em Ciências Biológicas - Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Quincozes-Santos A; Programa de Pós-Graduação em Ciências Biológicas - Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.; Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
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Źródło:
Neurotoxicity research [Neurotox Res] 2021 Jun; Vol. 39 (3), pp. 966-974. Date of Electronic Publication: 2021 Mar 30.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Homocysteine/*metabolism
Homocysteine/*toxicity
Neurodegenerative Diseases/*chemically induced
Neurodegenerative Diseases/*metabolism
Neuroglia/*drug effects
Neuroglia/*metabolism
Animals ; Astrocytes/drug effects ; Astrocytes/metabolism ; Astrocytes/pathology ; Gliosis/chemically induced ; Gliosis/metabolism ; Gliosis/pathology ; Humans ; Hyperhomocysteinemia/chemically induced ; Hyperhomocysteinemia/metabolism ; Hyperhomocysteinemia/pathology ; Neurodegenerative Diseases/pathology ; Neuroglia/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Severe Hyperhomocysteinemia Decreases Respiratory Enzyme and Na(+)-K(+) ATPase Activities, and Leads to Mitochondrial Alterations in Rat Amygdala.
Autorzy:
Kolling J; Laboratório de Neuroproteção e Doenças Neurometabólicas, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600-Anexo, Porto Alegre, RS, 90035-003, Brazil.; Laboratório de Erros Inatos do Metabolismo, Departamento de Bioquímica, ICBS, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600-Anexo, Porto Alegre, RS, 90035-003, Brazil.
Scherer EB; Laboratório de Neuroproteção e Doenças Neurometabólicas, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600-Anexo, Porto Alegre, RS, 90035-003, Brazil.; Laboratório de Erros Inatos do Metabolismo, Departamento de Bioquímica, ICBS, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600-Anexo, Porto Alegre, RS, 90035-003, Brazil.
Siebert C; Laboratório de Neuroproteção e Doenças Neurometabólicas, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600-Anexo, Porto Alegre, RS, 90035-003, Brazil.; Laboratório de Erros Inatos do Metabolismo, Departamento de Bioquímica, ICBS, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600-Anexo, Porto Alegre, RS, 90035-003, Brazil.
Longoni A; Laboratório de Neuroproteção e Doenças Neurometabólicas, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600-Anexo, Porto Alegre, RS, 90035-003, Brazil.; Laboratório de Erros Inatos do Metabolismo, Departamento de Bioquímica, ICBS, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600-Anexo, Porto Alegre, RS, 90035-003, Brazil.
Loureiro S; Laboratório de Neuroproteção e Doenças Neurometabólicas, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600-Anexo, Porto Alegre, RS, 90035-003, Brazil.; Laboratório de Erros Inatos do Metabolismo, Departamento de Bioquímica, ICBS, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600-Anexo, Porto Alegre, RS, 90035-003, Brazil.
Weis S; Laboratório de Neuroproteção e Doenças Neurometabólicas, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600-Anexo, Porto Alegre, RS, 90035-003, Brazil.; Laboratório de Erros Inatos do Metabolismo, Departamento de Bioquímica, ICBS, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600-Anexo, Porto Alegre, RS, 90035-003, Brazil.
Petenuzzo L; Laboratório de Neuroproteção e Doenças Neurometabólicas, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600-Anexo, Porto Alegre, RS, 90035-003, Brazil.; Laboratório de Erros Inatos do Metabolismo, Departamento de Bioquímica, ICBS, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600-Anexo, Porto Alegre, RS, 90035-003, Brazil.
Wyse AT; Laboratório de Neuroproteção e Doenças Neurometabólicas, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600-Anexo, Porto Alegre, RS, 90035-003, Brazil. .; Laboratório de Erros Inatos do Metabolismo, Departamento de Bioquímica, ICBS, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600-Anexo, Porto Alegre, RS, 90035-003, Brazil. .
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Źródło:
Neurotoxicity research [Neurotox Res] 2016 Apr; Vol. 29 (3), pp. 408-18. Date of Electronic Publication: 2015 Dec 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Amygdala/*metabolism
Creatine/*administration & dosage
Electron Transport Chain Complex Proteins/*metabolism
Hyperhomocysteinemia/*metabolism
Mitochondria/*metabolism
Sodium-Potassium-Exchanging ATPase/*metabolism
Amygdala/drug effects ; Animals ; Apoptosis/drug effects ; Electron Transport Chain Complex Proteins/drug effects ; Electron Transport Complex IV/metabolism ; Female ; Homocysteine/blood ; Homocysteine/toxicity ; Hyperhomocysteinemia/chemically induced ; Male ; Mitochondria/drug effects ; Necrosis/chemically induced ; Rats ; Rats, Wistar ; Succinate Dehydrogenase/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 220

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