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Tytuł:
HCN2 Channels in the Ventral Hippocampal CA1 Regulate Nociceptive Hypersensitivity in Mice.
Autorzy:
Zheng Y; Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Shao S; Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Zhang Y; National Health Commission Key Laboratory of Human Disease Comparative Medicine, Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, Institute of Laboratory Animal Science, Chinese Academy of Medical Science (CAMS) & Peking Union Medical College (PUMC), Beijing 100101, China.
Yuan S; Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Xing Y; Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Wang J; Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Qi X; Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Cui K; Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Tong J; Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Liu F; Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Cui S; Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Wan Y; Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.; Key Laboratory for Neuroscience, Ministry of Education/National Health Commission, Peking University, Beijing 100101, China.
Yi M; Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.; Key Laboratory for Neuroscience, Ministry of Education/National Health Commission, Peking University, Beijing 100101, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Sep 07; Vol. 24 (18). Date of Electronic Publication: 2023 Sep 07.
Typ publikacji:
Journal Article
MeSH Terms:
Chronic Pain*
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels*/genetics
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels*/metabolism
Potassium Channels*/genetics
Potassium Channels*/metabolism
Animals ; Mice ; Action Potentials ; Cyclic Nucleotide-Gated Cation Channels/metabolism ; Nociception ; CA1 Region, Hippocampal/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Dysfunction of Ca Channels in Hereditary and Chronic Human Heart Diseases and Experimental Animal Models.
Autorzy:
Shemarova I; I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, 194223 Saint-Petersburg, Russia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Oct 27; Vol. 24 (21). Date of Electronic Publication: 2023 Oct 27.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels*
Heart Failure*
Animals ; Humans ; Arrhythmias, Cardiac/genetics ; Models, Animal ; Calcium Channels/genetics ; Cyclic Nucleotide-Gated Cation Channels/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Xenon's Sedative Effect Is Mediated by Interaction with the Cyclic Nucleotide-Binding Domain (CNBD) of HCN2 Channels Expressed by Thalamocortical Neurons of the Ventrobasal Nucleus in Mice.
Autorzy:
Kassab NED; Department of Anesthesiology and Intensive Care Medicine, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich, 81675 Munich, Germany.
Mehlfeld V; Department of Pharmacy-Center for Drug Research, Ludwig-Maximilians-Universitñt Mnchen, 81377 Munich, Germany.
Kass J; Department of Pharmacy-Center for Drug Research, Ludwig-Maximilians-Universitñt Mnchen, 81377 Munich, Germany.
Biel M; Department of Pharmacy-Center for Drug Research, Ludwig-Maximilians-Universitñt Mnchen, 81377 Munich, Germany.
Schneider G; Department of Anesthesiology and Intensive Care Medicine, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich, 81675 Munich, Germany.
Rammes G; Department of Anesthesiology and Intensive Care Medicine, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich, 81675 Munich, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 May 11; Vol. 24 (10). Date of Electronic Publication: 2023 May 11.
Typ publikacji:
Journal Article
MeSH Terms:
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels*/metabolism
Potassium Channels*/metabolism
Xenon*/pharmacology
Animals ; Mice ; Cyclic Nucleotide-Gated Cation Channels/metabolism ; Hypnotics and Sedatives/pharmacology ; Neurons/metabolism ; Nucleotides, Cyclic/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Conversion of Unmodified Stem Cells to Pacemaker Cells by Overexpression of Key Developmental Genes.
Autorzy:
Karimi T; Heart and Vascular Institute, Department of Medicine, Tulane University Health Science Center, 1430 Tulane Ave, New Orleans, LA 70112, USA.; Alliance of Cardiovascular Researchers, 2211 Augusta Dr #10, Houston, TX 77057, USA.
Pan Z; University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Potaman VN; Alliance of Cardiovascular Researchers, 2211 Augusta Dr #10, Houston, TX 77057, USA.; InGeneron Inc., 8205 El Rio Street, Houston, TX 77054, USA.
Alt EU; Heart and Vascular Institute, Department of Medicine, Tulane University Health Science Center, 1430 Tulane Ave, New Orleans, LA 70112, USA.; Alliance of Cardiovascular Researchers, 2211 Augusta Dr #10, Houston, TX 77057, USA.; InGeneron Inc., 8205 El Rio Street, Houston, TX 77054, USA.; Sanford Health, University of South Dakota, Sioux Falls, SD 57104, USA.; Isar Klinikum Munich, Sonnenstr 24-26, 80331 Munich, Germany.
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Źródło:
Cells [Cells] 2023 May 13; Vol. 12 (10). Date of Electronic Publication: 2023 May 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels*/genetics
Myocytes, Cardiac*/metabolism
Humans ; Heart Conduction System ; Stem Cells/metabolism ; Genes, Developmental
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
An LQT2-related mutation in the voltage-sensing domain is involved in switching the gating polarity of hERG.
Autorzy:
Liu Z; Zhongshan Institute for Drug Discovery, Zhongshan, 528400, China.; Center for Neurological and Psychiatric Research and Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Wang F; School of Pharmacy, Zunyi Medical University, Zunyi, 563000, China.; Zhongshan Institute for Drug Discovery, Zhongshan, 528400, China.
Yuan H; School of Pharmacy, Zunyi Medical University, Zunyi, 563000, China.; Zhongshan Institute for Drug Discovery, Zhongshan, 528400, China.
Tian F; Zhongshan Institute for Drug Discovery, Zhongshan, 528400, China.; Center for Neurological and Psychiatric Research and Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Yang C; Zhongshan Institute for Drug Discovery, Zhongshan, 528400, China.; Center for Neurological and Psychiatric Research and Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
Hu F; Zhongshan Institute for Drug Discovery, Zhongshan, 528400, China.; Center for Neurological and Psychiatric Research and Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Liu Y; Zhongshan Institute for Drug Discovery, Zhongshan, 528400, China.
Tang M; Zhongshan Institute for Drug Discovery, Zhongshan, 528400, China.; School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China.
Ping M; Zhongshan Institute for Drug Discovery, Zhongshan, 528400, China.; Center for Neurological and Psychiatric Research and Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.
Kang C; Zhongshan Institute for Drug Discovery, Zhongshan, 528400, China.; School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China.
Luo T; Zhongshan Institute for Drug Discovery, Zhongshan, 528400, China.; School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang, 550025, China.
Yang G; School of Pharmacy, Zunyi Medical University, Zunyi, 563000, China.; Zhongshan Institute for Drug Discovery, Zhongshan, 528400, China.
Hu M; Zhongshan Institute for Drug Discovery, Zhongshan, 528400, China.; Pharmacology Laboratory, Zhongshan Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Zhongshan, 528401, China.
Gao Z; School of Pharmacy, Zunyi Medical University, Zunyi, 563000, China. .; Zhongshan Institute for Drug Discovery, Zhongshan, 528400, China. .; Center for Neurological and Psychiatric Research and Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. .; University of Chinese Academy of Sciences, Beijing, 100049, China. .
Li P; School of Pharmacy, Zunyi Medical University, Zunyi, 563000, China. .; Zhongshan Institute for Drug Discovery, Zhongshan, 528400, China. .; Center for Neurological and Psychiatric Research and Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. .; University of Chinese Academy of Sciences, Beijing, 100049, China. .
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Źródło:
BMC biology [BMC Biol] 2024 Feb 05; Vol. 22 (1), pp. 29. Date of Electronic Publication: 2024 Feb 05.
Typ publikacji:
Journal Article
MeSH Terms:
Ion Channel Gating*/genetics
ERG1 Potassium Channel*/genetics
Humans ; Amino Acid Sequence ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/genetics ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/metabolism ; Mutation ; Nucleotides, Cyclic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Modelling and analysis of cAMP-induced mixed-mode oscillations in cortical neurons: Critical roles of HCN and M-type potassium channels.
Autorzy:
Martin M; Department of Information Engineering, University of Padova, Padova, Italy.
Pedersen MG; Department of Information Engineering, University of Padova, Padova, Italy.
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Źródło:
PLoS computational biology [PLoS Comput Biol] 2024 Mar 22; Vol. 20 (3), pp. e1011559. Date of Electronic Publication: 2024 Mar 22 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
Potassium Channels*/chemistry
Nucleotides, Cyclic*/pharmacology
Neurons ; Cyclic AMP ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/physiology ; Cyclic Nucleotide-Gated Cation Channels
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Chronic but not acute nicotine treatment ameliorates acute inflammation-induced working memory impairment by increasing CRTC1 and HCN2 in adult male mice.
Autorzy:
Wang X; School of Life Science, Nanchang University, Nanchang, China.; Institute of Biomedical Innovation, Jiangxi Medical College, Nanchang University, Nanchang, China.
Wang Q; Department of Histology and Embryology, School of Basic Medical Sciences, Advanced Innovation Center for Human Brain Protection, Beijing Key Laboratory of Cancer Invasion and Metastasis Research, Capital Medical University, Beijing, China.
Song M; Institute of Neuroscience, The Second The Second Affiliated Hospital of Soochow University, Suzhou, China.
Wang Y; Department of Histology and Embryology, School of Basic Medical Sciences, Advanced Innovation Center for Human Brain Protection, Beijing Key Laboratory of Cancer Invasion and Metastasis Research, Capital Medical University, Beijing, China.
Shen X; Institute of Neuroscience, The Second The Second Affiliated Hospital of Soochow University, Suzhou, China.
Sun Y; Institute of Neuroscience, The Second The Second Affiliated Hospital of Soochow University, Suzhou, China.
Guo C; School of Biosciences, University of Sheffield, Sheffield, UK.
Geng P; Department of Histology and Embryology, School of Basic Medical Sciences, Advanced Innovation Center for Human Brain Protection, Beijing Key Laboratory of Cancer Invasion and Metastasis Research, Capital Medical University, Beijing, China.
Ma C; School of Life Science, Nanchang University, Nanchang, China.; Institute of Biomedical Innovation, Jiangxi Medical College, Nanchang University, Nanchang, China.
Jin X; Department of Histology and Embryology, School of Basic Medical Sciences, Advanced Innovation Center for Human Brain Protection, Beijing Key Laboratory of Cancer Invasion and Metastasis Research, Capital Medical University, Beijing, China.; Institute of Neuroscience, The Second The Second Affiliated Hospital of Soochow University, Suzhou, China.
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Źródło:
CNS neuroscience & therapeutics [CNS Neurosci Ther] 2024 Feb; Vol. 30 (2), pp. e14627.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Memory, Short-Term*/physiology
Nicotine*/pharmacology
Nicotine*/therapeutic use
Nicotine*/metabolism
Humans ; Mice ; Male ; Animals ; Tumor Necrosis Factor-alpha/metabolism ; Lipopolysaccharides/toxicity ; Memory Disorders/drug therapy ; Memory Disorders/etiology ; Memory Disorders/metabolism ; Hippocampus/metabolism ; Transcription Factors/metabolism ; Inflammation/chemically induced ; Inflammation/drug therapy ; Inflammation/metabolism ; Interleukin-1beta/metabolism ; Potassium Channels/metabolism ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Sedative Properties of Dexmedetomidine Are Mediated Independently from Native Thalamic Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel Function at Clinically Relevant Concentrations.
Autorzy:
Schwerin S; Department of Anesthesiology and Intensive Care Medicine, Klinikum Rechts der Isar, Technical University of Munich School of Medicine, 81675 Munich, Germany.
Westphal C; Department of Anesthesiology and Intensive Care Medicine, Klinikum Rechts der Isar, Technical University of Munich School of Medicine, 81675 Munich, Germany.
Klug C; Department of Anesthesiology and Intensive Care Medicine, Klinikum Rechts der Isar, Technical University of Munich School of Medicine, 81675 Munich, Germany.
Schneider G; Department of Anesthesiology and Intensive Care Medicine, Klinikum Rechts der Isar, Technical University of Munich School of Medicine, 81675 Munich, Germany.
Kreuzer M; Department of Anesthesiology and Intensive Care Medicine, Klinikum Rechts der Isar, Technical University of Munich School of Medicine, 81675 Munich, Germany.
Haseneder R; Department of Anesthesiology and Intensive Care Medicine, Klinikum Rechts der Isar, Technical University of Munich School of Medicine, 81675 Munich, Germany.
Kratzer S; Department of Anesthesiology and Intensive Care Medicine, Klinikum Rechts der Isar, Technical University of Munich School of Medicine, 81675 Munich, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Dec 28; Vol. 24 (1). Date of Electronic Publication: 2022 Dec 28.
Typ publikacji:
Journal Article
MeSH Terms:
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels*/metabolism
Dexmedetomidine*/pharmacology
Mice ; Animals ; Cyclic Nucleotide-Gated Cation Channels/metabolism ; Hypnotics and Sedatives/pharmacology ; Thalamus/metabolism ; Adrenergic alpha-2 Receptor Agonists/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
HCN2 channel-induced rescue of brain, eye, heart and gut teratogenesis caused by nicotine, ethanol and aberrant notch signalling.
Autorzy:
Pai VP; Allen Discovery Center at Tufts University, Medford, Massachusetts, USA.
Levin M; Allen Discovery Center at Tufts University, Medford, Massachusetts, USA.
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Źródło:
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society [Wound Repair Regen] 2022 Nov; Vol. 30 (6), pp. 681-706. Date of Electronic Publication: 2022 Jun 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Ethanol*/adverse effects
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels*/metabolism
Nicotine*/adverse effects
Potassium Channels*/metabolism
Teratogenesis*
Humans ; Receptors, Notch
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
When Is a Potassium Channel Not a Potassium Channel?
Autorzy:
Accili E; Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
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Źródło:
Function (Oxford, England) [Function (Oxf)] 2022 Oct 07; Vol. 3 (6), pp. zqac052. Date of Electronic Publication: 2022 Oct 07 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Potassium Channels*/chemistry
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels*
Cyclic Nucleotide-Gated Cation Channels/physiology ; Potassium ; Sodium
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Positive chronotropic action of HCN channel antagonism in human collecting lymphatic vessels.
Autorzy:
Majgaard J; Department of Biomedicine, Aarhus University, Aarhus, Denmark.
Skov FG; Department of Biomedicine, Aarhus University, Aarhus, Denmark.
Kim S; Department of Biomedicine, Aarhus University, Aarhus, Denmark.
Hjortdal VE; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Aarhus, Denmark.
Boedtkjer DMB; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
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Źródło:
Physiological reports [Physiol Rep] 2022 Aug; Vol. 10 (16), pp. e15401.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels*/metabolism
Lymphatic Vessels*
Cesium/metabolism ; Cesium/pharmacology ; Humans ; Ivabradine ; Muscle Contraction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Identification of HCN1 as a 14-3-3 client.
Autorzy:
Lankford C; Department of Biochemistry and Molecular Biology, University of Iowa, Iowa City, Iowa, United States of America.
Houtman J; Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, United States of America.
Baker SA; Department of Biochemistry and Molecular Biology, University of Iowa, Iowa City, Iowa, United States of America.
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Źródło:
PloS one [PLoS One] 2022 Jun 09; Vol. 17 (6), pp. e0268335. Date of Electronic Publication: 2022 Jun 09 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels*/genetics
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels*/metabolism
Potassium Channels*/genetics
Potassium Channels*/metabolism
Animals ; Cyclic Nucleotide-Gated Cation Channels/metabolism ; HEK293 Cells ; Humans ; Mice ; Neurons/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Functional and structural characterization of interactions between opposite subunits in HCN pacemaker channels.
Autorzy:
Kondapuram M; Universitätsklinikum Jena, Institut für Physiologie II, Jena, Germany.
Frieg B; John von Neumann-Institut für Computing (NIC), Jülich Supercomputing Centre (JSC), and Institut für Biologische Informationsprozesse (IBI-7: Strukturbiochemie), Forschungszentrum Jülich GmbH, Jülich, Germany.
Yüksel S; Universitätsklinikum Jena, Institut für Physiologie II, Jena, Germany.
Schwabe T; Universitätsklinikum Jena, Institut für Physiologie II, Jena, Germany.
Sattler C; Universitätsklinikum Jena, Institut für Physiologie II, Jena, Germany.
Lelle M; Universitätsklinikum Jena, Institut für Physiologie II, Jena, Germany.
Schweinitz A; Universitätsklinikum Jena, Institut für Physiologie II, Jena, Germany.
Schmauder R; Universitätsklinikum Jena, Institut für Physiologie II, Jena, Germany.
Benndorf K; Universitätsklinikum Jena, Institut für Physiologie II, Jena, Germany.
Gohlke H; John von Neumann-Institut für Computing (NIC), Jülich Supercomputing Centre (JSC), and Institut für Biologische Informationsprozesse (IBI-7: Strukturbiochemie), Forschungszentrum Jülich GmbH, Jülich, Germany. .; Institut für Pharmazeutische und Medizinische Chemie, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany. .; Institut für Bio- und Geowissenschaften (IBG-4: Bioinformatik), Forschungszentrum Jülich GmbH, Jülich, Germany. .
Kusch J; Universitätsklinikum Jena, Institut für Physiologie II, Jena, Germany. .
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Źródło:
Communications biology [Commun Biol] 2022 May 09; Vol. 5 (1), pp. 430. Date of Electronic Publication: 2022 May 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels*/chemistry
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels*/genetics
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels*/metabolism
Nucleotides, Cyclic*
Cyclic AMP ; Ion Channel Gating ; Patch-Clamp Techniques
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Effects of Axonal Demyelination, Inflammatory Cytokines and Divalent Cation Chelators on Thalamic HCN Channels and Oscillatory Bursting.
Autorzy:
Oniani T; Institute of Physiology I, Westfälische Wilhelms-Universität, Robert-Koch-Str. 27a, D-48149 Münster, Germany.
Vinnenberg L; Department of Neurology with Institute of Translational Neurology, Albert-Schweitzer-Campus 1, D-48149 Münster, Germany.
Chaudhary R; Institute of Physiology I, Westfälische Wilhelms-Universität, Robert-Koch-Str. 27a, D-48149 Münster, Germany.
Schreiber JA; Institute of Pharmaceutical and Medicinal Chemistry, Westfälische Wilhelms-Universität, Corren-Str. 48, D-48149 Münster, Germany.; Cellular Electrophysiology and Molecular Biology, Department of Cardiovascular Medicine, Institute for Genetics of Heart Diseases (IfGH), University Hospital Münster, Robert-Koch-Str. 45, D-48149 Münster, Germany.
Riske K; European Institute for Molecular Imaging (EIMI), Westfälische Wilhelms-Universität, Waldeyer-Str. 15, D-48149 Münster, Germany.
Williams B; Center for Systems Neuroscience, Neurophotonics Center, Department of Biomedical Engineering, Boston University, 610 Commonwealth Ave., Boston, MA 02215, USA.
Pape HC; Institute of Physiology I, Westfälische Wilhelms-Universität, Robert-Koch-Str. 27a, D-48149 Münster, Germany.
White JA; Center for Systems Neuroscience, Neurophotonics Center, Department of Biomedical Engineering, Boston University, 610 Commonwealth Ave., Boston, MA 02215, USA.
Junker A; European Institute for Molecular Imaging (EIMI), Westfälische Wilhelms-Universität, Waldeyer-Str. 15, D-48149 Münster, Germany.
Seebohm G; Cellular Electrophysiology and Molecular Biology, Department of Cardiovascular Medicine, Institute for Genetics of Heart Diseases (IfGH), University Hospital Münster, Robert-Koch-Str. 45, D-48149 Münster, Germany.
Meuth SG; Neurology Clinic, University Clinic Düsseldorf, Moorenstraße 5, D-40225 Düsseldorf, Germany.
Hundehege P; Department of Neurology with Institute of Translational Neurology, Albert-Schweitzer-Campus 1, D-48149 Münster, Germany.
Budde T; Institute of Physiology I, Westfälische Wilhelms-Universität, Robert-Koch-Str. 27a, D-48149 Münster, Germany.
Zobeiri M; Institute of Physiology I, Westfälische Wilhelms-Universität, Robert-Koch-Str. 27a, D-48149 Münster, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Jun 03; Vol. 23 (11). Date of Electronic Publication: 2022 Jun 03.
Typ publikacji:
Journal Article
MeSH Terms:
Demyelinating Diseases*/chemically induced
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels*/genetics
Animals ; Cations, Divalent ; Chelating Agents/pharmacology ; Copper ; Cytokines ; Mice ; Mice, Inbred C57BL
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Stretch-Induced Down-Regulation of HCN2 Suppresses Contractile Activity.
Autorzy:
Kola JB; Department of Medical Chemistry, School of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Turarova B; Department of Medical Chemistry, School of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Csige D; Department of Medical Chemistry, School of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Sipos Á; Department of Medical Chemistry, School of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Varga L; Department of Medical Chemistry, School of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Gergely B; Department of Medical Chemistry, School of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Refai FA; Department of Medical Chemistry, School of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Uray IP; Department of Clinical Oncology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Docsa T; Department of Medical Chemistry, School of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Uray K; Department of Medical Chemistry, School of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 May 26; Vol. 28 (11). Date of Electronic Publication: 2023 May 26.
Typ publikacji:
Journal Article
MeSH Terms:
Potassium Channels*/genetics
Potassium Channels*/metabolism
Ileus*
Humans ; Cyclic Nucleotide-Gated Cation Channels/genetics ; Cyclic Nucleotide-Gated Cation Channels/metabolism ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/genetics ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/metabolism ; Down-Regulation
Czasopismo naukowe
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Tytuł:
Multiple neuron clusters on Micro-Electrode Arrays as an in vitro model of brain network.
Autorzy:
Brofiga M; Department of Informatics, Bioengineering, Robotics, Systems Engineering (DIBRIS), University of Genova, Genova, Italy.; ScreenNeuroPharm, Sanremo, Italy.
Losacco S; Department of Pharmacy (DIFAR), University of Genova, Genova, Italy.
Poggio F; Department of Informatics, Bioengineering, Robotics, Systems Engineering (DIBRIS), University of Genova, Genova, Italy.
Zerbo RA; Department of Pharmacy (DIFAR), Pharmacology and Toxicology Unit, University of Genova, Genova, Italy.
Milanese M; Department of Pharmacy (DIFAR), Pharmacology and Toxicology Unit, University of Genova, Genova, Italy.; IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132, Genova, Italy.
Massobrio P; Department of Informatics, Bioengineering, Robotics, Systems Engineering (DIBRIS), University of Genova, Genova, Italy. .; National Institute for Nuclear Physics (INFN), Genova, Italy. .
Burlando B; Department of Pharmacy (DIFAR), University of Genova, Genova, Italy.
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Źródło:
Scientific reports [Sci Rep] 2023 Sep 20; Vol. 13 (1), pp. 15604. Date of Electronic Publication: 2023 Sep 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Pacemaker, Artificial*
Animals ; Rats ; Brain ; Central Nervous System ; Electrodes ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
DNA methylation cooperates with H3K9me2 at HCN4 promoter to regulate the differentiation of bone marrow mesenchymal stem cells into pacemaker-like cells.
Autorzy:
Sun X; Department of Cardiology, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, Jiangsu, The People's Republic of China.
Jin K; Department of Cardiology, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, Jiangsu, The People's Republic of China.
Ding X; Department of Cardiology, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, Jiangsu, The People's Republic of China.
Ruan Z; Department of Cardiology, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, Jiangsu, The People's Republic of China.
Xu P; Department of Haematology, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, Jiangsu, The People's Republic of China.
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Źródło:
PloS one [PLoS One] 2023 Aug 29; Vol. 18 (8), pp. e0289510. Date of Electronic Publication: 2023 Aug 29 (Print Publication: 2023).
Typ publikacji:
Journal Article
MeSH Terms:
DNA Methylation*
Mesenchymal Stem Cells*
Cell Differentiation ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/genetics ; Promoter Regions, Genetic ; Animals ; Rats
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Weak Cation Selectivity in HCN Channels Results From K From Selectivity Filter Binding Sites.
Autorzy:
Bauer D; Department of Biology and Centre for Synthetic Biology, TU Darmstadt, Schnittspahnstrasse 3, 64287 Darmstadt, Germany.
Wissmann J; Department of Physics, TU Darmstadt, Schlossgartenstrasse 7, 64289 Darmstadt, Germany.
Moroni A; Department of Biosciences, University of Milan, via Celoria 26, 20133 Milan, Italy.
Thiel G; Department of Biology and Centre for Synthetic Biology, TU Darmstadt, Schnittspahnstrasse 3, 64287 Darmstadt, Germany.
Hamacher K; Department of Biology and Centre for Synthetic Biology, TU Darmstadt, Schnittspahnstrasse 3, 64287 Darmstadt, Germany.; Department of Physics, TU Darmstadt, Schlossgartenstrasse 7, 64289 Darmstadt, Germany.
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Źródło:
Function (Oxford, England) [Function (Oxf)] 2022 Apr 22; Vol. 3 (3), pp. zqac019. Date of Electronic Publication: 2022 Apr 22 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels*/metabolism
Potassium Channels*/chemistry
Cations/metabolism ; Binding Sites ; Sodium/metabolism ; Potassium/chemistry
Czasopismo naukowe
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Tytuł:
Repurposing hyperpolarization-activated cyclic nucleotide-gated channels as a novel therapy for breast cancer.
Autorzy:
Mok KC; Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong.
Tsoi H; Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong.
Man EP; Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong.
Leung MH; Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong.
Chau KM; Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong.
Wong LS; Department of Clinical Oncology, Queen Mary Hospital, Hong Kong, Hong Kong.
Chan WL; Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong.
Chan SY; Department of Clinical Oncology, Queen Mary Hospital, Hong Kong, Hong Kong.
Luk MY; Department of Clinical Oncology, Queen Mary Hospital, Hong Kong, Hong Kong.
Chan JYW; Department of Surgery, Pamela Youde Nethersole Eastern Hospital, Hong Kong, Hong Kong.
Leung JKM; Department of Surgery, Pamela Youde Nethersole Eastern Hospital, Hong Kong, Hong Kong.
Chan YHY; Department of Surgery, Kwong Wah Hospital, Hong Kong, Hong Kong.
Batalha S; Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong.
Lau V; Department of Medicine, The University of Hong Kong, Hong Kong, Hong Kong.
Siu DCW; Department of Medicine, The University of Hong Kong, Hong Kong, Hong Kong.
Lee TKW; Department of Applied Biology & Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, Hong Kong.
Gong C; Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong.
Khoo US; Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong.
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Źródło:
Clinical and translational medicine [Clin Transl Med] 2021 Nov; Vol. 11 (11), pp. e578.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/*metabolism
Triple Negative Breast Neoplasms/*drug therapy
Cell Line/drug effects ; Cell Line/physiology ; Female ; Humans ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/therapeutic use ; Ivabradine/metabolism ; Ivabradine/therapeutic use
Czasopismo naukowe
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Tytuł:
Structural Identification of the Pacemaker Cells and Expression of Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channels in the Heart of the Wild Atlantic Cod, Gadus morhua (Linnaeus, 1758).
Autorzy:
Capillo G; Department of Veterinary Sciences, Polo Universitario dell'Annunziata, University of Messina, 98168 Messina, Italy.; Institute of Marine Biological Resources and Biotechnology-National Research Council (IRBIM, CNR), Spianata S. Raineri, 98122 Messina, Italy.
Lauriano ER; Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, 98168 Messina, Italy.
Icardo JM; Department of Anatomy and Cell Biology, Poligono de Cazona, Faculty of Medicine, University of Cantabria, 39011 Santander, Spain.
Siriyappagouder P; Faculty of Biosciences and Aquaculture, Nord University, 8026 Bodø, Norway.
Kuciel M; Poison Information Centre, Department of Toxicology and Environmental Disease, Faculty of Medicine, Jagiellonian University, Kopernika 15, 30-501 Cracow, Poland.
Karapanagiotis S; Faculty of Biosciences and Aquaculture, Nord University, 8026 Bodø, Norway.
Zaccone G; Department of Veterinary Sciences, Polo Universitario dell'Annunziata, University of Messina, 98168 Messina, Italy.
Fernandes JMO; Faculty of Biosciences and Aquaculture, Nord University, 8026 Bodø, Norway.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 14; Vol. 22 (14). Date of Electronic Publication: 2021 Jul 14.
Typ publikacji:
Journal Article
MeSH Terms:
Ion Channel Gating*
Gadus morhua/*metabolism
Heart/*physiology
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/*chemistry
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/*metabolism
Myocytes, Cardiac/*metabolism
Animals ; Fish Proteins/chemistry ; Fish Proteins/genetics ; Fish Proteins/metabolism ; Gadus morhua/genetics ; Gadus morhua/growth & development ; Heart/innervation ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/genetics ; Myocytes, Cardiac/cytology ; Protein Isoforms ; Synaptic Transmission
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 5565

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