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Wyszukujesz frazę ""Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels"" wg kryterium: Temat


Tytuł :
Structural Identification of the Pacemaker Cells and Expression of Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channels in the Heart of the Wild Atlantic Cod, Gadus morhua (Linnaeus, 1758).
Autorzy :
Capillo G; Department of Veterinary Sciences, Polo Universitario dell'Annunziata, University of Messina, 98168 Messina, Italy.; Institute of Marine Biological Resources and Biotechnology-National Research Council (IRBIM, CNR), Spianata S. Raineri, 98122 Messina, Italy.
Lauriano ER; Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, 98168 Messina, Italy.
Icardo JM; Department of Anatomy and Cell Biology, Poligono de Cazona, Faculty of Medicine, University of Cantabria, 39011 Santander, Spain.
Siriyappagouder P; Faculty of Biosciences and Aquaculture, Nord University, 8026 Bodø, Norway.
Kuciel M; Poison Information Centre, Department of Toxicology and Environmental Disease, Faculty of Medicine, Jagiellonian University, Kopernika 15, 30-501 Cracow, Poland.
Karapanagiotis S; Faculty of Biosciences and Aquaculture, Nord University, 8026 Bodø, Norway.
Zaccone G; Department of Veterinary Sciences, Polo Universitario dell'Annunziata, University of Messina, 98168 Messina, Italy.
Fernandes JMO; Faculty of Biosciences and Aquaculture, Nord University, 8026 Bodø, Norway.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 14; Vol. 22 (14). Date of Electronic Publication: 2021 Jul 14.
Typ publikacji :
Journal Article
MeSH Terms :
Ion Channel Gating*
Gadus morhua/*metabolism
Heart/*physiology
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/*chemistry
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/*metabolism
Myocytes, Cardiac/*metabolism
Animals ; Fish Proteins/chemistry ; Fish Proteins/genetics ; Fish Proteins/metabolism ; Gadus morhua/genetics ; Gadus morhua/growth & development ; Heart/innervation ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/genetics ; Myocytes, Cardiac/cytology ; Protein Isoforms ; Synaptic Transmission
Czasopismo naukowe
Tytuł :
A rare HCN4 variant with combined sinus bradycardia, left atrial dilatation, and hypertrabeculation/left ventricular noncompaction phenotype.
Autorzy :
Alonso-Fernández-Gatta M; Servicio de Cardiología, Complejo Asistencial Universitario de Salamanca, Universidad de Salamanca, Salamanca, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain; Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, Spain.
Gallego-Delgado M; Servicio de Cardiología, Complejo Asistencial Universitario de Salamanca, Universidad de Salamanca, Salamanca, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain; Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, Spain; Centro de Referencia Nacional de Cardiopatías Familiares (CSUR), Salamanca, Spain.
Caballero R; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain; Departamento de Farmacología y Toxicología, Facultad de Medicina, Universidad Complutense de Madrid; Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.
Villacorta E; Servicio de Cardiología, Complejo Asistencial Universitario de Salamanca, Universidad de Salamanca, Salamanca, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain; Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, Spain; Centro de Referencia Nacional de Cardiopatías Familiares (CSUR), Salamanca, Spain. Electronic address: .
Díaz-Peláez E; Servicio de Cardiología, Complejo Asistencial Universitario de Salamanca, Universidad de Salamanca, Salamanca, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain; Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, Spain; Centro de Referencia Nacional de Cardiopatías Familiares (CSUR), Salamanca, Spain.
García-BerrocaL B; Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, Spain; Centro de Referencia Nacional de Cardiopatías Familiares (CSUR), Salamanca, Spain; Unidad de Genética, Servicio de Bioquímica, Complejo Asistencial Universitario de Salamanca. Universidad de Salamanca, Salamanca, Spain.
Crespo-García T; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain; Departamento de Farmacología y Toxicología, Facultad de Medicina, Universidad Complutense de Madrid; Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.
Plata-Izquierdo B; Centro de Referencia Nacional de Cardiopatías Familiares (CSUR), Salamanca, Spain; Servicio de Pediatría, Complejo Asistencial Universitario de Salamanca, Salamanca, Spain.
Marcos-Vadillo E; Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, Spain; Centro de Referencia Nacional de Cardiopatías Familiares (CSUR), Salamanca, Spain; Unidad de Genética, Servicio de Bioquímica, Complejo Asistencial Universitario de Salamanca. Universidad de Salamanca, Salamanca, Spain.
García-Cuenllas L; Centro de Referencia Nacional de Cardiopatías Familiares (CSUR), Salamanca, Spain; Servicio de Pediatría, Complejo Asistencial Universitario de Salamanca, Salamanca, Spain.
Barreiro-Pérez M; Servicio de Cardiología, Complejo Asistencial Universitario de Salamanca, Universidad de Salamanca, Salamanca, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain; Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, Spain.
Isidoro-García M; Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, Spain; Centro de Referencia Nacional de Cardiopatías Familiares (CSUR), Salamanca, Spain; Unidad de Genética, Servicio de Bioquímica, Complejo Asistencial Universitario de Salamanca. Universidad de Salamanca, Salamanca, Spain.
Tamargo-Menéndez J; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain; Departamento de Farmacología y Toxicología, Facultad de Medicina, Universidad Complutense de Madrid; Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.
Delpón E; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain; Departamento de Farmacología y Toxicología, Facultad de Medicina, Universidad Complutense de Madrid; Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.
Sánchez PL; Servicio de Cardiología, Complejo Asistencial Universitario de Salamanca, Universidad de Salamanca, Salamanca, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain; Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, Spain; Centro de Referencia Nacional de Cardiopatías Familiares (CSUR), Salamanca, Spain.
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Źródło :
Revista espanola de cardiologia (English ed.) [Rev Esp Cardiol (Engl Ed)] 2021 Sep; Vol. 74 (9), pp. 781-789. Date of Electronic Publication: 2020 Sep 30.
Typ publikacji :
Journal Article
MeSH Terms :
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels*/genetics
Sick Sinus Syndrome*/diagnosis
Sick Sinus Syndrome*/genetics
Animals ; Bradycardia/diagnosis ; Bradycardia/genetics ; CHO Cells ; Cricetinae ; Cricetulus ; Dilatation ; Humans ; Muscle Proteins/genetics ; Phenotype ; Potassium Channels/genetics
Czasopismo naukowe
Tytuł :
Loss of HCN2 in Dorsal Hippocampus of Young Adult Mice Induces Specific Apoptosis of the CA1 Pyramidal Neuron Layer.
Autorzy :
Deutsch M; Research Center Jülich, Institute of Biological Information Processing, IBI-1, 52428 Jülich, Germany.; Department of Biology, University of California, San Diego, La Jolla, CA 92083, USA.
Stegmayr C; Research Center Jülich, Institute of Neuroscience and Medicine, INM-4, 52428 Jülich, Germany.
Balfanz S; Research Center Jülich, Institute of Biological Information Processing, IBI-1, 52428 Jülich, Germany.
Baumann A; Research Center Jülich, Institute of Biological Information Processing, IBI-1, 52428 Jülich, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 22; Vol. 22 (13). Date of Electronic Publication: 2021 Jun 22.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*genetics
CA1 Region, Hippocampal/*metabolism
Hippocampus/*metabolism
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/*deficiency
Potassium Channels/*deficiency
Pyramidal Cells/*metabolism
Age Factors ; Animals ; CA1 Region, Hippocampal/pathology ; Gene Knockdown Techniques ; Hippocampus/pathology ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/chemistry ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/metabolism ; Immunohistochemistry ; Mice ; Potassium Channels/chemistry ; Potassium Channels/metabolism ; Protein Binding ; Protein Interaction Domains and Motifs ; Pyramidal Cells/pathology ; RNA Interference
Czasopismo naukowe
Tytuł :
Electromechanical coupling mechanism for activation and inactivation of an HCN channel.
Autorzy :
Dai G; Department of Physiology and Biophysics, University of Washington, Seattle, WA, USA. .
Aman TK; Department of Physiology and Biophysics, University of Washington, Seattle, WA, USA.
DiMaio F; Department of Biochemistry, University of Washington, Seattle, WA, USA.
Zagotta WN; Department of Physiology and Biophysics, University of Washington, Seattle, WA, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 May 14; Vol. 12 (1), pp. 2802. Date of Electronic Publication: 2021 May 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/*chemistry
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/*metabolism
Animals ; Cyclic AMP ; Cyclic Nucleotide-Gated Cation Channels/antagonists & inhibitors ; Cyclic Nucleotide-Gated Cation Channels/chemistry ; Cyclic Nucleotide-Gated Cation Channels/metabolism ; Female ; Fluorescence Resonance Energy Transfer ; Humans ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/antagonists & inhibitors ; Ion Channel Gating ; Male ; Mechanotransduction, Cellular ; Membrane Potentials ; Models, Molecular ; Oocytes/metabolism ; Patch-Clamp Techniques ; Protein Conformation, alpha-Helical ; Protein Domains ; Sea Urchins/metabolism ; Spermatozoa/metabolism ; Xenopus/metabolism
Czasopismo naukowe
Tytuł :
Cohesin-protein Shugoshin-1 controls cardiac automaticity via HCN4 pacemaker channel.
Autorzy :
Liu D; Montreal Heart Institute, Department of Medicine, Université de Montréal, Montréal, QC, Canada.
Song AT; Department of Anatomy and Cell Biology, McGill University, Montréal, QC, Canada.; Cardiovascular Genetics, Department of Pediatrics, Centre Hospitalier Universitaire Sainte-Justine Research Centre, University of Montreal, Montréal, QC, Canada.
Qi X; Montreal Heart Institute, Department of Medicine, Université de Montréal, Montréal, QC, Canada.
van Vliet PP; Cardiovascular Genetics, Department of Pediatrics, Centre Hospitalier Universitaire Sainte-Justine Research Centre, University of Montreal, Montréal, QC, Canada.; LIA (International Associated Laboratory) INSERM, Marseille, France.; LIA (International Associated Laboratory) Centre Hospitalier Universitaire Sainte-Justine, Montréal, QC, Canada.
Xiao J; Montreal Heart Institute, Department of Medicine, Université de Montréal, Montréal, QC, Canada.
Xiong F; Montreal Heart Institute, Department of Medicine, Université de Montréal, Montréal, QC, Canada.; Department of Pharmacology and Therapeutics, McGill University, Montréal, QC, Canada.
Andelfinger G; Cardiovascular Genetics, Department of Pediatrics, Centre Hospitalier Universitaire Sainte-Justine Research Centre, University of Montreal, Montréal, QC, Canada.; Department of Pediatrics, University of Montreal, Montréal, QC, Canada.; Department of Biochemistry, University of Montreal, Montréal, QC, Canada.
Nattel S; Montreal Heart Institute, Department of Medicine, Université de Montréal, Montréal, QC, Canada. .; Department of Pharmacology and Therapeutics, McGill University, Montréal, QC, Canada. .; Institute of Pharmacology, West German Heart and Vascular Center, Faculty of Medicine, University Duisburg-Essen, Essen, Germany. .; IHU LIRYC Institute, Fondation Bordeaux Université, Bordeaux, France. .
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Źródło :
Nature communications [Nat Commun] 2021 May 05; Vol. 12 (1), pp. 2551. Date of Electronic Publication: 2021 May 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Cycle Proteins/*metabolism
Chromosomal Proteins, Non-Histone/*metabolism
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/*metabolism
Muscle Proteins/*metabolism
Potassium Channels/*metabolism
Animals ; Arrhythmias, Cardiac ; Cell Cycle Proteins/genetics ; Cell Line ; Cell Survival ; Chromosomal Proteins, Non-Histone/genetics ; Gene Knockdown Techniques ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/genetics ; Induced Pluripotent Stem Cells/metabolism ; Ion Transport/physiology ; Muscle Proteins/genetics ; Myocardial Contraction ; Myocytes, Cardiac/metabolism ; Pacemaker, Artificial ; Potassium Channels/genetics ; Rats
Czasopismo naukowe
Tytuł :
cAMP-PKA signaling is involved in regulation of spinal HCN channels function in diabetic neuropathic pain.
Autorzy :
Ma Y; Department of Physiology, Zunyi Medical University, Zunyi, 563000, China.
Chen J; School of Pharmacy, Qingdao University, Qingdao 266000, China.
Yu D; Department of Physiology, Zunyi Medical University, Zunyi, 563000, China.
Wei B; Department of Physiology, Zunyi Medical University, Zunyi, 563000, China.
Jin H; Department of Physiology, Zunyi Medical University, Zunyi, 563000, China.
Zeng J; Department of Physiology, Zunyi Medical University, Zunyi, 563000, China.
Liu X; Department of Physiology, Zunyi Medical University, Zunyi, 563000, China. Electronic address: .
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Źródło :
Neuroscience letters [Neurosci Lett] 2021 Apr 17; Vol. 750, pp. 135763. Date of Electronic Publication: 2021 Feb 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Nociception*
Cyclic AMP/*metabolism
Cyclic AMP-Dependent Protein Kinases/*metabolism
Diabetic Neuropathies/*metabolism
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/*metabolism
Spinal Cord/*metabolism
Animals ; Cyclic AMP/antagonists & inhibitors ; Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors ; Diabetic Neuropathies/physiopathology ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/antagonists & inhibitors ; Isoquinolines/pharmacology ; Male ; Protein Kinase Inhibitors/pharmacology ; Rats ; Rats, Sprague-Dawley ; Signal Transduction ; Spinal Cord/physiology ; Sulfonamides/pharmacology
Czasopismo naukowe
Tytuł :
Cholinergic receptor-independent modulation of intrinsic resonance in the rat subiculum neurons through inhibition of hyperpolarization-activated cyclic nucleotide-gated channels.
Autorzy :
Vasnik S; Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India.
Sikdar SK; Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India.
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Źródło :
Acta physiologica (Oxford, England) [Acta Physiol (Oxf)] 2021 Apr; Vol. 231 (4), pp. e13603. Date of Electronic Publication: 2021 Jan 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels*/metabolism
Pyramidal Cells*/metabolism
Action Potentials ; Animals ; Hippocampus ; Neurons/metabolism ; Rats ; Receptors, Cholinergic
Czasopismo naukowe
Tytuł :
Allosteric signaling in C-linker and cyclic nucleotide-binding domain of HCN2 channels.
Autorzy :
Pfleger C; Mathematisch-Naturwissenschaftliche Fakultät, Institut für Pharmazeutische und Medizinische Chemie, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany.
Kusch J; Institute of Physiology II, Jena University Hospital, Jena, Germany.
Kondapuram M; Institute of Physiology II, Jena University Hospital, Jena, Germany.
Schwabe T; Institute of Physiology II, Jena University Hospital, Jena, Germany.
Sattler C; Institute of Physiology II, Jena University Hospital, Jena, Germany.
Benndorf K; Institute of Physiology II, Jena University Hospital, Jena, Germany.
Gohlke H; Mathematisch-Naturwissenschaftliche Fakultät, Institut für Pharmazeutische und Medizinische Chemie, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany; John von Neumann Institute for Computing, Jülich Supercomputing Centre, and Institute of Biological Information Processing (IBI-7, Structural Biochemistry), Forschungszentrum Jülich, Jülich, Germany. Electronic address: .
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Źródło :
Biophysical journal [Biophys J] 2021 Mar 02; Vol. 120 (5), pp. 950-963. Date of Electronic Publication: 2021 Jan 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels*/metabolism
Ion Channel Gating*
Animals ; Cyclic AMP/metabolism ; Cyclic Nucleotide-Gated Cation Channels ; Mice ; Nucleotides, Cyclic ; Protein Binding
Czasopismo naukowe
Tytuł :
Key Roles of Cyclooxygenase 2-Protein Kinase A-Hyperpolarization-activated Cyclic Nucleotide-gated Channel 3 Pathway in the Regulation of Oxytocin Neuronal Activity in Lactating Rats with Intermittent Pup-Deprivation.
Autorzy :
Li D; Department of Physiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Liu X; Department of Physiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Liu H; Department of Physiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Li T; Department of Physiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Jia S; Department of Physiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Wang X; Department of Physiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Wang P; Department of Genetics, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Qin D; Department of Physiology, Shantou University of Medical College, Shantou, China.
Wang YF; Department of Physiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China. Electronic address: .
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Źródło :
Neuroscience [Neuroscience] 2021 Jan 01; Vol. 452, pp. 13-25. Date of Electronic Publication: 2020 Oct 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels*
Oxytocin*/metabolism
Animals ; Cyclic AMP-Dependent Protein Kinases ; Cyclic Nucleotide-Gated Cation Channels ; Cyclooxygenase 2 ; Female ; Lactation ; Neurons/metabolism ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Detection of ligand binding to purified HCN channels using fluorescence-based size exclusion chromatography.
Autorzy :
Saponaro A; Department of Biosciences, University of Milan, Milan, Italy.
Sharifzadeh AS; Department of Biosciences, University of Milan, Milan, Italy.
Moroni A; Department of Biosciences, University of Milan, Milan, Italy. Electronic address: .
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Źródło :
Methods in enzymology [Methods Enzymol] 2021; Vol. 652, pp. 105-123. Date of Electronic Publication: 2021 Feb 27.
Typ publikacji :
Journal Article
MeSH Terms :
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels*/genetics
Animals ; Chromatography, Gel ; Ligands
Czasopismo naukowe
Tytuł :
Inhibition of hyperpolarization-activated cyclic nucleotide-gated channels with natural flavonoid quercetin.
Autorzy :
Liang Y; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Xu Z; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Wu X; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Pang J; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Zhou P; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China. Electronic address: .
Cao Y; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Dec 17; Vol. 533 (4), pp. 952-957. Date of Electronic Publication: 2020 Sep 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/*antagonists & inhibitors
Quercetin/*pharmacology
Animals ; COS Cells ; Chlorocebus aethiops ; Drug Evaluation, Preclinical ; Electrophysiological Phenomena ; Flavonoids/chemistry ; Flavonoids/pharmacology ; Flavonols/chemistry ; Flavonols/pharmacology ; Humans ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/genetics ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/metabolism ; Muscle Proteins/antagonists & inhibitors ; Muscle Proteins/genetics ; Muscle Proteins/metabolism ; Patch-Clamp Techniques ; Potassium Channels/genetics ; Potassium Channels/metabolism ; Quercetin/chemistry ; Recombinant Proteins/drug effects ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
The structure and function of TRIP8b, an auxiliary subunit of hyperpolarization-activated cyclic-nucleotide gated channels.
Autorzy :
Han Y; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
Lyman KA; Department of Neurology, Stanford University, Palo Alto, CA, USA.
Foote KM; Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Chetkovich DM; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
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Źródło :
Channels (Austin, Tex.) [Channels (Austin)] 2020 Dec; Vol. 14 (1), pp. 110-122.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/*chemistry
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/*metabolism
Receptors, Cytoplasmic and Nuclear/*chemistry
Receptors, Cytoplasmic and Nuclear/*metabolism
Animals ; Epilepsy/genetics ; Epilepsy/metabolism ; Humans ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/genetics ; Models, Biological ; Phosphorylation ; Receptors, Cytoplasmic and Nuclear/genetics
Czasopismo naukowe
Tytuł :
Metabolic acidosis and hyperkalemia differentially regulate cation HCN3 channel in the rat nephron.
Autorzy :
López-González Z; Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), 04510, Mexico, Mexico.
Padilla-Flores T; Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), 04510, Mexico, Mexico.
León-Aparicio D; Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), 04510, Mexico, Mexico.
Gutiérrez-Vásquez E; Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), 04510, Mexico, Mexico.
Salvador C; Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), 04510, Mexico, Mexico.
León-Contreras JC; Departamento de Patología, Instituto Nacional de Ciencias Médicas Y Nutrición Salvador Zubirán, 14080, Mexico, Mexico.
Hernández-Pando R; Departamento de Patología, Instituto Nacional de Ciencias Médicas Y Nutrición Salvador Zubirán, 14080, Mexico, Mexico.
Escobar LI; Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), 04510, Mexico, Mexico. .
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Źródło :
Journal of molecular histology [J Mol Histol] 2020 Dec; Vol. 51 (6), pp. 701-716. Date of Electronic Publication: 2020 Oct 18.
Typ publikacji :
Journal Article
MeSH Terms :
Acidosis/*etiology
Acidosis/*metabolism
Hyperkalemia/*etiology
Hyperkalemia/*metabolism
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/*metabolism
Nephrons/*metabolism
Potassium Channels/*metabolism
Animals ; Biomarkers ; Chronic Disease ; Epithelial Cells/metabolism ; Fluorescent Antibody Technique/methods ; Gene Expression ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/genetics ; Kidney Tubules, Proximal/metabolism ; Loop of Henle/metabolism ; Nephrons/ultrastructure ; Potassium Channels/genetics ; Rats
Czasopismo naukowe
Tytuł :
Ectopic HCN4 expression drives mTOR-dependent epilepsy in mice.
Autorzy :
Hsieh LS; Department of Neurosurgery, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA.
Wen JH; Department of Neurosurgery, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA.
Nguyen LH; Department of Neurosurgery, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA.
Zhang L; Department of Neurosurgery, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA.; Department of Neurosurgery, Xiangya Hospital, Xiangya Hospital, Central South University, 87 Xiangya Street, Changsha, Hunan 410008, China.
Getz SA; Department of Neurosurgery, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA.
Torres-Reveron J; Department of Neurosurgery, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA.
Wang Y; Emergency Department, Xiangya Hospital, Central South University, 87 Xiangya Street, Changsha, Hunan 410008, China.
Spencer DD; Department of Neurosurgery, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA.
Bordey A; Department of Neurosurgery, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA. .; Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA.
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Źródło :
Science translational medicine [Sci Transl Med] 2020 Nov 18; Vol. 12 (570).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Epilepsy*/genetics
Malformations of Cortical Development, Group I*
Tuberous Sclerosis*/genetics
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/*metabolism
Humans ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/genetics ; Muscle Proteins ; Potassium Channels/genetics ; TOR Serine-Threonine Kinases/metabolism
Czasopismo naukowe
Tytuł :
Involvement of NMDA receptors in tremor expression in Aspa/Hcn1 double-knockout rats.
Autorzy :
Nishitani A; Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.
Nagayoshi H; Osaka Institute of Public Health, 1-3-69 Nakamichi, Higashinari-ku, Osaka 537-0025, Japan.
Takenaka S; Department of Clinical Nutrition, Graduate School of Comprehensive Rehabilitation, Osaka Prefecture University, 3-7-30 Habikino, Osaka 583-8555, Japan.
Asano M; Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.
Shimizu S; Department of Pharmacology, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan.
Ohno Y; Department of Pharmacology, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan.
Kuramoto T; Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.; Department of Animal Science, Faculty of Agriculture, Tokyo University of Agriculture, 1737 Funako, Atsugi, Kanagawa 243-0034, Japan.
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Źródło :
Experimental animals [Exp Anim] 2020 Nov 12; Vol. 69 (4), pp. 388-394. Date of Electronic Publication: 2020 Jun 05.
Typ publikacji :
Journal Article
MeSH Terms :
Amidohydrolases/*genetics
Essential Tremor/*genetics
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/*genetics
Potassium Channels/*genetics
Receptors, N-Methyl-D-Aspartate/*antagonists & inhibitors
Receptors, N-Methyl-D-Aspartate/*physiology
Amidohydrolases/metabolism ; Animals ; Brain/metabolism ; Essential Tremor/drug therapy ; Gene Knockout Techniques ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/metabolism ; Molecular Targeted Therapy ; Phenols/pharmacology ; Phenols/therapeutic use ; Piperidines/pharmacology ; Piperidines/therapeutic use ; Potassium Channels/metabolism ; Quinoxalines/pharmacology ; Quinoxalines/therapeutic use ; Rats, Inbred F344 ; Rats, Mutant Strains ; Spinal Cord/metabolism
Czasopismo naukowe
Tytuł :
Chronic morphine induces cyclic adenosine monophosphate formation and hyperpolarization-activated cyclic nucleotide-gated channel expression in the spinal cord of mice.
Autorzy :
Yuan L; Department of Anesthesiology, Tongzhou People's Hospital, Nantong, 226300, China.
Luo L; Department of Anesthesiology, Affiliated Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, 200233, China.
Ma X; Department of Anesthesiology, Affiliated Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, 200233, China.
Wang W; Department of Anesthesiology, Affiliated Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, 200233, China.
Yu K; Department of Pathology, Tongzhou People's Hospital, Nantong, 226300, China.
Shi H; Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai, 200233, China.
Chen J; Department of Orthopaedics, Tongzhou People's Hospital, Nantong, 226300, China. Electronic address: .
Chen D; Department of Oncology, Tongzhou People's Hospital, Nantong, 226300, China. Electronic address: .
Xu T; Department of Anesthesiology, Tongzhou People's Hospital, Nantong, 226300, China; Department of Anesthesiology, Affiliated Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, 200233, China. Electronic address: .
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Źródło :
Neuropharmacology [Neuropharmacology] 2020 Oct 01; Vol. 176, pp. 108222. Date of Electronic Publication: 2020 Jul 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Analgesics, Opioid/*administration & dosage
Cyclic AMP/*metabolism
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/*metabolism
Morphine/*administration & dosage
Spinal Cord/*metabolism
Animals ; Cyclic AMP/analysis ; Cyclic Nucleotide-Gated Cation Channels/analysis ; Cyclic Nucleotide-Gated Cation Channels/metabolism ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/analysis ; Male ; Mice ; Mice, Inbred C57BL ; Spinal Cord/chemistry ; Spinal Cord/drug effects
Czasopismo naukowe
Tytuł :
A potential role for hyperpolarization-activated cyclic nucleotide-gated sodium/potassium channels (HCNs) in teleost acid-base and ammonia regulation.
Autorzy :
Fehsenfeld S; Université du Quebec à Rimouski, Département de biologie, chimie et géographie, 300 Allée des Ursulines, Rimouski, QC G5L 3A1, Canada; University of British Columbia, Department of Zoology, 4200 - 6270 University Blvd., Vancouver, BC V6T 1Z4, Canada. Electronic address: .
Wood CM; University of British Columbia, Department of Zoology, 4200 - 6270 University Blvd., Vancouver, BC V6T 1Z4, Canada.
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Źródło :
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology [Comp Biochem Physiol B Biochem Mol Biol] 2020 Oct - Nov; Vol. 248-249, pp. 110469. Date of Electronic Publication: 2020 Jul 10.
Typ publikacji :
Journal Article
MeSH Terms :
Ammonia/*pharmacology
Goldfish/*metabolism
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/*metabolism
Acid-Base Equilibrium ; Amino Acid Sequence ; Ammonia/pharmacokinetics ; Animal Feed ; Animals ; Bicarbonates/pharmacology ; Glycoproteins/genetics ; Glycoproteins/metabolism ; Goldfish/genetics ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/genetics ; Phylogeny ; Protein Isoforms ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Sequence Homology ; Tissue Distribution
Czasopismo naukowe
Tytuł :
Expression of the pacemaker channel HCN4 in excitatory interneurons in the dorsal horn of the murine spinal cord.
Autorzy :
Nakagawa T; Department of Physiology, Kurume University School of Medicine, 67 Asahi-Machi, Kurume, 830-0011, Japan.; Department of Anesthesiology, Graduate School of Medicine, Kyushu University, Fukuoka, 812-8582, Japan.
Yasaka T; Department of Health and Nutrition, Niigata University of Hearth and Welfare, Niigata, 950-3198, Japan.
Nakashima N; Department of Physiology, Kurume University School of Medicine, 67 Asahi-Machi, Kurume, 830-0011, Japan.
Takeya M; Department of Physiology, Kurume University School of Medicine, 67 Asahi-Machi, Kurume, 830-0011, Japan.
Oshita K; Department of Physiology, Kurume University School of Medicine, 67 Asahi-Machi, Kurume, 830-0011, Japan.; Department of Anesthesiology, Kurume University School of Medicine, Kurume, 830-0011, Japan.
Tsuda M; Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, 812-8582, Japan.
Yamaura K; Department of Anesthesiology, Graduate School of Medicine, Kyushu University, Fukuoka, 812-8582, Japan.
Takano M; Department of Physiology, Kurume University School of Medicine, 67 Asahi-Machi, Kurume, 830-0011, Japan. .
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Źródło :
Molecular brain [Mol Brain] 2020 Sep 18; Vol. 13 (1), pp. 127. Date of Electronic Publication: 2020 Sep 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/*metabolism
Interneurons/*metabolism
Spinal Cord Dorsal Horn/*metabolism
Animals ; Antibody Specificity ; Genetic Loci ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/immunology ; Luminescence ; Mice, Transgenic ; Nociception ; Parvalbumins/metabolism ; Presynaptic Terminals/metabolism ; Protein Kinase C/metabolism ; Vesicular Glutamate Transport Protein 2/metabolism ; Vesicular Inhibitory Amino Acid Transport Proteins/metabolism
Czasopismo naukowe
Tytuł :
HCN2 activation modulation: An electrophysiological and molecular study of the well-preserved LCI sequence in the pore channel.
Autorzy :
Hernandez A; Departamento de Neurobiología Celular y Molecular, Laboratorio de Neurobiología Molecular y Celular, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Juriquilla, 76230, Santiago de Querétaro, Querétaro, Mexico. Electronic address: .
Hernández-Centeno R; Departamento de Neurobiología Celular y Molecular, Laboratorio de Neurobiología Molecular y Celular, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Juriquilla, 76230, Santiago de Querétaro, Querétaro, Mexico.
Espino-Saldaña ÁE; Departamento de Neurobiología Celular y Molecular, Laboratorio de Neurobiología Molecular y Celular, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Juriquilla, 76230, Santiago de Querétaro, Querétaro, Mexico.
Martínez-Torres A; Departamento de Neurobiología Celular y Molecular, Laboratorio de Neurobiología Molecular y Celular, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Juriquilla, 76230, Santiago de Querétaro, Querétaro, Mexico. Electronic address: .
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Źródło :
Archives of biochemistry and biophysics [Arch Biochem Biophys] 2020 Aug 15; Vol. 689, pp. 108436. Date of Electronic Publication: 2020 May 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/*metabolism
Xenopus/*metabolism
Xenopus Proteins/*metabolism
Amino Acid Sequence ; Animals ; Cells, Cultured ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/chemistry ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/genetics ; Ion Channel Gating ; Membrane Potentials ; Mutagenesis, Site-Directed ; Oocytes/metabolism ; Permeability ; Potassium/metabolism ; Sodium/metabolism ; Xenopus/genetics ; Xenopus Proteins/chemistry ; Xenopus Proteins/genetics
Czasopismo naukowe
Tytuł :
Isoform-specific regulation of HCN4 channels by a family of endoplasmic reticulum proteins.
Autorzy :
Peters CH; Department of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.
Myers ME; Department of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.
Juchno J; Department of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.
Haimbaugh C; Department of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.
Bichraoui H; Department of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.
Du Y; Department of Medicine, Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.
Bankston JR; Department of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.
Walker LA; Department of Medicine, Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.
Proenza C; Department of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045; .; Department of Medicine, Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Jul 28; Vol. 117 (30), pp. 18079-18090. Date of Electronic Publication: 2020 Jul 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Endoplasmic Reticulum/*metabolism
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/*metabolism
Animals ; CHO Cells ; Cell Line ; Cricetulus ; Cyclic AMP/metabolism ; Gene Expression Regulation ; Humans ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/chemistry ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/genetics ; Male ; Membrane Potentials/drug effects ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Mice ; Models, Biological ; Multigene Family ; Myocytes, Cardiac/metabolism ; Phosphoproteins/metabolism ; Protein Binding ; Protein Interaction Domains and Motifs ; Protein Isoforms ; Sinoatrial Node/physiology ; Sinoatrial Node/physiopathology
Czasopismo naukowe

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