Temat: "Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Silencing miR-370-3p rescues funny current and sinus node function in heart failure.
Autorzy:: Yanni J; Division of Cardiovascular Sciences, University of Manchester, 46 Grafton Street, Manchester, M13 9NT, UK.
D'Souza A; Division of Cardiovascular Sciences, University of Manchester, 46 Grafton Street, Manchester, M13 9NT, UK.
Wang Y; Division of Cardiovascular Sciences, University of Manchester, 46 Grafton Street, Manchester, M13 9NT, UK.
Li N; Physiology and Cell Biology, Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA.; Bob and Corrine Frick Center for Heart Failure and Arrhythmia Research and Dorothy M. Davis Heart and Lung Research Institute, Ohio State University, Columbus, OH, 43210, USA.
Hansen BJ; Physiology and Cell Biology, Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA.; Bob and Corrine Frick Center for Heart Failure and Arrhythmia Research and Dorothy M. Davis Heart and Lung Research Institute, Ohio State University, Columbus, OH, 43210, USA.
Zakharkin SO; Physiology and Cell Biology, Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA.
Smith M; Division of Cardiovascular Sciences, University of Manchester, 46 Grafton Street, Manchester, M13 9NT, UK.
Hayward C; Division of Cardiovascular Sciences, University of Manchester, 46 Grafton Street, Manchester, M13 9NT, UK.
Whitson BA; Bob and Corrine Frick Center for Heart Failure and Arrhythmia Research and Dorothy M. Davis Heart and Lung Research Institute, Ohio State University, Columbus, OH, 43210, USA.; Department of Surgery, Division of Cardiac Surgery, Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA.
Mohler PJ; Physiology and Cell Biology, Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA.; Bob and Corrine Frick Center for Heart Failure and Arrhythmia Research and Dorothy M. Davis Heart and Lung Research Institute, Ohio State University, Columbus, OH, 43210, USA.; Department of Internal Medicine, Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA.
Janssen PML; Physiology and Cell Biology, Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA.; Bob and Corrine Frick Center for Heart Failure and Arrhythmia Research and Dorothy M. Davis Heart and Lung Research Institute, Ohio State University, Columbus, OH, 43210, USA.; Department of Internal Medicine, Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA.
Zeef L; Bioinformatics Core Facility, University of Manchester, Manchester, UK.
Choudhury M; Division of Cardiovascular Sciences, University of Manchester, 46 Grafton Street, Manchester, M13 9NT, UK.
Zi M; Division of Cardiovascular Sciences, University of Manchester, 46 Grafton Street, Manchester, M13 9NT, UK.
Cai X; Division of Cardiovascular Sciences, University of Manchester, 46 Grafton Street, Manchester, M13 9NT, UK.
Logantha SJRJ; Division of Cardiovascular Sciences, University of Manchester, 46 Grafton Street, Manchester, M13 9NT, UK.; Liverpool Centre for Cardiovascular Science, University of Liverpool, Liverpool, UK.
Nakao S; Division of Cardiovascular Sciences, University of Manchester, 46 Grafton Street, Manchester, M13 9NT, UK.
Atkinson A; Division of Cardiovascular Sciences, University of Manchester, 46 Grafton Street, Manchester, M13 9NT, UK.
Petkova M; Division of Cardiovascular Sciences, University of Manchester, 46 Grafton Street, Manchester, M13 9NT, UK.
Doris U; Division of Cardiovascular Sciences, University of Manchester, 46 Grafton Street, Manchester, M13 9NT, UK.
Ariyaratnam J; Division of Cardiovascular Sciences, University of Manchester, 46 Grafton Street, Manchester, M13 9NT, UK.
Cartwright EJ; Division of Cardiovascular Sciences, University of Manchester, 46 Grafton Street, Manchester, M13 9NT, UK.
Griffiths-Jones S; Division of Evolution and Genomics Sciences, University of Manchester, Manchester, UK.
Hart G; Division of Cardiovascular Sciences, University of Manchester, 46 Grafton Street, Manchester, M13 9NT, UK.
Fedorov VV; Physiology and Cell Biology, Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA.; Bob and Corrine Frick Center for Heart Failure and Arrhythmia Research and Dorothy M. Davis Heart and Lung Research Institute, Ohio State University, Columbus, OH, 43210, USA.
Oceandy D; Division of Cardiovascular Sciences, University of Manchester, 46 Grafton Street, Manchester, M13 9NT, UK.
Dobrzynski H; Division of Cardiovascular Sciences, University of Manchester, 46 Grafton Street, Manchester, M13 9NT, UK.; Department of Anatomy, Jagiellonian University Medical College, Kraków, Poland.
Boyett MR; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, 2200N, Copenhagen, Denmark. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2020 Jul 09; Vol. 10 (1), pp. 11279. Date of Electronic Publication: 2020 Jul 09.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Gene Silencing*
Heart Failure/*genetics
Heart Failure/*physiopathology
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/*metabolism
MicroRNAs/*metabolism
Sinoatrial Node/*physiopathology
Animals ; Binding Sites ; Body Weight ; Cardiomegaly ; Computational Biology ; Down-Regulation ; Fibrosis ; Heart Failure/metabolism ; Heart Rate ; Humans ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/genetics ; Male ; Mice ; Mice, Inbred C57BL ; MicroRNAs/genetics ; Rats

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Skocz do pozycji: 2.

Tytuł:: Sinus node-like pacemaker mechanisms regulate ectopic pacemaker activity in the adult rat atrioventricular ring.
Autorzy:: Logantha SJRJ; Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom. .
Kharche SR; Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.; Lawson's Health Research Institute, Department of Medical Biophysics, University of Western Ontario, London, ON, Canada.
Zhang Y; Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.
Atkinson AJ; Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.
Hao G; Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.
Boyett MR; Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.
Dobrzynski H; Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2019 Aug 13; Vol. 9 (1), pp. 11781. Date of Electronic Publication: 2019 Aug 13.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Pacemaker, Artificial*
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/*genetics
Sarcoplasmic Reticulum Calcium-Transporting ATPases/*genetics
Sinoatrial Node/*metabolism
Tachycardia, Supraventricular/*genetics
Action Potentials/physiology ; Animals ; Atrioventricular Node/metabolism ; Atrioventricular Node/physiopathology ; Calcium Signaling/genetics ; Carbachol/pharmacology ; Cardiac Electrophysiology ; Disease Models, Animal ; Heart Atria/metabolism ; Heart Atria/pathology ; Heart Rate/physiology ; Humans ; Isoproterenol/pharmacology ; Rats ; Receptor, Muscarinic M2/genetics ; Receptors, Adrenergic, beta-2/genetics ; Sinoatrial Node/physiopathology ; Sympathetic Nervous System/drug effects ; Tachycardia, Supraventricular/metabolism ; Tachycardia, Supraventricular/pathology

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Skocz do pozycji: 3.

Tytuł:: Development of a Rat Model of Sick Sinus Syndrome Using Pinpoint Press Permeation.
Autorzy:: Zhong HB; Fujian Hypertension Research Institute, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.; Xiang'an Branch, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.
Wang TJ; Fujian Hypertension Research Institute, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Lian GL; Fujian Hypertension Research Institute, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Xu CS; Fujian Hypertension Research Institute, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Wang HJ; Fujian Hypertension Research Institute, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Xie LD; Fujian Hypertension Research Institute, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.; Pokaż więcej
Źródło:: BioMed research international [Biomed Res Int] 2018 Nov 18; Vol. 2018, pp. 7487324. Date of Electronic Publication: 2018 Nov 18 (Print Publication: 2018).
Typ publikacji:: Journal Article
MeSH Terms:: Sick Sinus Syndrome/*physiopathology
Sinoatrial Node/*physiopathology
Animals ; Disease Models, Animal ; Heart Atria/metabolism ; Heart Atria/physiopathology ; Heart Rate/physiology ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/metabolism ; Male ; Rats ; Rats, Sprague-Dawley ; Sick Sinus Syndrome/metabolism ; Sinoatrial Node/metabolism

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Skocz do pozycji: 4.

Tytuł:: Reduced expression of HCN channels in the sinoatrial node of streptozotocin-induced diabetic rats.
Autorzy:: Huang X; a Department of Cardiology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, P.R. China, 710061.
Zhong N; b Department of Cardiology, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, P.R. China, 710068.
Zhang H; c School of Electrical Engineering, Xi'an Jiaotong University, Xi'an, Shaanxi, P.R. China, 710049.
Ma A; a Department of Cardiology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, P.R. China, 710061.
Yuan Z; a Department of Cardiology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, P.R. China, 710061.
Guo N; a Department of Cardiology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, P.R. China, 710061.; Pokaż więcej
Źródło:: Canadian journal of physiology and pharmacology [Can J Physiol Pharmacol] 2017 May; Vol. 95 (5), pp. 586-594. Date of Electronic Publication: 2016 Dec 23.
Typ publikacji:: Journal Article
MeSH Terms:: Gene Expression Regulation*/drug effects
Diabetes Mellitus, Experimental/*genetics
Diabetes Mellitus, Experimental/*metabolism
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/*genetics
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/*metabolism
Sinoatrial Node/*metabolism
Animals ; Benzazepines/pharmacology ; Diabetes Mellitus, Experimental/physiopathology ; Ivabradine ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Rats ; Rats, Sprague-Dawley ; Sinoatrial Node/drug effects ; Sinoatrial Node/physiopathology

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Skocz do pozycji: 5.

Tytuł:: Pacemaker activity of the human sinoatrial node: an update on the effects of mutations in HCN4 on the hyperpolarization-activated current.
Autorzy:: Verkerk AO; Department of Anatomy, Embryology and Physiology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands. .
Wilders R; Department of Anatomy, Embryology and Physiology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands. .; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2015 Jan 29; Vol. 16 (2), pp. 3071-94. Date of Electronic Publication: 2015 Jan 29.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/*genetics
Sinoatrial Node/*metabolism
Action Potentials ; Humans ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/metabolism ; Mutation ; Potassium Channels, Voltage-Gated/genetics ; Potassium Channels, Voltage-Gated/metabolism ; Sick Sinus Syndrome/metabolism ; Sick Sinus Syndrome/pathology

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Skocz do pozycji: 6.

Tytuł:: Berberine attenuates spontaneous action potentials in sinoatrial node cells and the currents of human HCN4 channels expressed in Xenopus laevis oocytes.
Autorzy:: Chen H; Department of Cardiology, Cardiovascular Research Institute, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei 430060, P.R. China.
Chen Y; Department of Cardiology, Cardiovascular Research Institute, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei 430060, P.R. China.
Tang Y; Department of Cardiology, Cardiovascular Research Institute, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei 430060, P.R. China.
Yang J; Department of Cardiology, Cardiovascular Research Institute, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei 430060, P.R. China.
Wang D; Department of Cardiology, Cardiovascular Research Institute, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei 430060, P.R. China.
Yu T; Department of Cardiology, Cardiovascular Research Institute, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei 430060, P.R. China.
Huang C; Department of Cardiology, Cardiovascular Research Institute, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei 430060, P.R. China.; Pokaż więcej
Źródło:: Molecular medicine reports [Mol Med Rep] 2014 Sep; Vol. 10 (3), pp. 1576-82. Date of Electronic Publication: 2014 Jul 14.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Anti-Arrhythmia Agents/*pharmacology
Berberine/*pharmacology
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/*metabolism
Muscle Proteins/*metabolism
Potassium Channels/*metabolism
Sinoatrial Node/*drug effects
Action Potentials/drug effects ; Animals ; Drugs, Chinese Herbal/pharmacology ; Female ; Heart/drug effects ; Humans ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/genetics ; Male ; Muscle Proteins/genetics ; Myocytes, Cardiac/drug effects ; Oocytes ; Potassium Channels/genetics ; Rabbits ; Sinoatrial Node/cytology ; Sinoatrial Node/metabolism ; Xenopus laevis

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Skocz do pozycji: 7.

Tytuł:: Mechanisms of spontaneous pacing: sinoatrial nodal cells, neonatal cardiomyocytes, and human stem cell derived cardiomyocytes.
Autorzy:: Morad M; Cardiac Signaling Center of University of South Carolina, Medical University of South Carolina and Clemson University, Charleston, SC 29425, USA.; Cardiac Signaling Center of University of South Carolina, Medical University of South Carolina and Clemson University, Charleston, SC 29425, USA.
Zhang XH; Cardiac Signaling Center of University of South Carolina, Medical University of South Carolina and Clemson University, Charleston, SC 29425, USA.; Cardiac Signaling Center of University of South Carolina, Medical University of South Carolina and Clemson University, Charleston, SC 29425, USA.; Pokaż więcej
Źródło:: Canadian journal of physiology and pharmacology [Can J Physiol Pharmacol] 2017 Oct; Vol. 95 (10), pp. 1100-1107. Date of Electronic Publication: 2017 Mar 28.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Biological Clocks*
Heart Rate*
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/*metabolism
Induced Pluripotent Stem Cells/*metabolism
Myocytes, Cardiac/*metabolism
Sinoatrial Node/*metabolism
Action Potentials ; Animals ; Calcium Signaling ; Cell Differentiation ; Connexins/metabolism ; Humans ; Mitochondria, Heart/metabolism ; Models, Cardiovascular ; Rats ; Sinoatrial Node/cytology ; Time Factors

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Skocz do pozycji: 8.

Tytuł:: The conduction system and expressions of hyperpolarization-activated cyclic nucleotide-gated cation channel 4 and connexin43 expressions in the hearts of fetal day 13 mice.
Autorzy:: Wen Y; a Department of Histology and Embryology , College of Basic Medical Sciences.
Li B; b Department of Sports Medicine, Shengjing Hospital , China Medical University , Shenyang , China.; Pokaż więcej
Źródło:: Biotechnic & histochemistry : official publication of the Biological Stain Commission [Biotech Histochem] 2017; Vol. 92 (2), pp. 86-91. Date of Electronic Publication: 2017 Feb 26.
Typ publikacji:: Journal Article
MeSH Terms:: Connexin 43/*metabolism
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/*metabolism
Myocardium/*metabolism
Sinoatrial Node/*metabolism
Animals ; Animals, Newborn ; Brugada Syndrome/metabolism ; Cardiac Conduction System Disease ; Cyclic Nucleotide-Gated Cation Channels/metabolism ; Female ; Heart/embryology ; Mice ; RNA, Messenger/metabolism

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Skocz do pozycji: 9.

Tytuł:: The Contribution of HCN4 to normal sinus node function in humans and animal models.
Autorzy:: Nof E; Masonic Medical Research Laboratory, Utica New York, USA.
Antzelevitch C
Glikson M; Pokaż więcej
Źródło:: Pacing and clinical electrophysiology : PACE [Pacing Clin Electrophysiol] 2010 Jan; Vol. 33 (1), pp. 100-6. Date of Electronic Publication: 2009 Oct 01.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms:: Cyclic Nucleotide-Gated Cation Channels/*physiology
Heart Rate/*physiology
Muscle Proteins/*physiology
Sinoatrial Node/*physiology
Animals ; Humans ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels ; Mice ; Potassium Channels

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Skocz do pozycji: 10.

Tytuł:: Role of I(K) and I(f) in the pacemaker mechanisms of sino-atrial node myocytes.
Autorzy:: Zhang H; Department of Physiology and Pharmacology, State University of New York, Health Science Center, Brooklyn 11203, USA.
Vassalle M; Pokaż więcej
Źródło:: Canadian journal of physiology and pharmacology [Can J Physiol Pharmacol] 2001 Dec; Vol. 79 (12), pp. 963-76.
Typ publikacji:: Journal Article; Research Support, U.S. Gov't, P.H.S.
MeSH Terms:: Potassium Channels, Voltage-Gated*
Biological Clocks/*physiology
Heart/*physiology
Ion Channels/*physiology
Potassium Channels/*physiology
Sinoatrial Node/*physiology
Action Potentials/physiology ; Algorithms ; Animals ; Axons/physiology ; Cyclic Nucleotide-Gated Cation Channels ; Delayed Rectifier Potassium Channels ; Electrophysiology ; Guinea Pigs ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels ; In Vitro Techniques ; Myocardium/cytology ; Patch-Clamp Techniques ; Sinoatrial Node/cytology

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Skocz do pozycji: 11.

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