Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Wyszukujesz frazę ""Hypoglycemic Agents"" wg kryterium: Temat


Tytuł :
1 H NMR-based metabonomics of the hypoglycemic effect of polysaccharides from Cordyceps militaris on streptozotocin-induced diabetes in mice.
Autorzy :
Shang XL; College of Life Science, Langfang Teachers University, Langfang, Hebei, P.R. China.
Pan LC; Key Laboratory of Food, Nutrition and Safety, Ministry of Education, College of Food Science and Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, P.R. China.
Tang Y; Key Laboratory of Food, Nutrition and Safety, Ministry of Education, College of Food Science and Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, P.R. China.
Luo Y; Key Laboratory of Food, Nutrition and Safety, Ministry of Education, College of Food Science and Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, P.R. China.
Zhu ZY; Key Laboratory of Food, Nutrition and Safety, Ministry of Education, College of Food Science and Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, P.R. China.
Sun HQ; Key Laboratory of Food, Nutrition and Safety, Ministry of Education, College of Food Science and Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, P.R. China.
Meng M; Key Laboratory of Food, Nutrition and Safety, Ministry of Education, College of Food Science and Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, P.R. China.
Zhang YM; Université Pierre et Marie Curie-Paris 6, Institute Parisien de Chimie Moléculaire, Paris, France.
Pokaż więcej
Źródło :
Natural product research [Nat Prod Res] 2020 May; Vol. 34 (10), pp. 1366-1372. Date of Electronic Publication: 2018 Nov 23.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat. Prod. Res. Subsets: MEDLINE
MeSH Terms :
Cordyceps/*chemistry
Diabetes Mellitus, Experimental/*drug therapy
Hypoglycemic Agents/*isolation & purification
Metabolomics/*methods
Polysaccharides/*isolation & purification
Animals ; Biomarkers/blood ; Blood Glucose/drug effects ; Blood Glucose/metabolism ; Blood Urea Nitrogen ; Diabetes Mellitus, Experimental/chemically induced ; Diabetes Mellitus, Experimental/metabolism ; Hypoglycemic Agents/chemistry ; Hypoglycemic Agents/metabolism ; Hypoglycemic Agents/pharmacology ; Mice ; Polysaccharides/chemistry ; Polysaccharides/pharmacology ; Polysaccharides/therapeutic use ; Proton Magnetic Resonance Spectroscopy ; Streptozocin
Czasopismo naukowe
Tytuł :
Exenatide ameliorates experimental non-alcoholic fatty liver in rats via suppression of toll-like receptor 4/NFκB signaling: Comparison to metformin.
Autorzy :
Saad ZA; Medical Administration, Suez Canal University, Ismailia, Egypt.
Khodeer DM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt. Electronic address: .
Zaitone SA; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt; Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia.
Ahmed AAM; Department of Histology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt.
Moustafa YM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt.
Pokaż więcej
Źródło :
Life sciences [Life Sci] 2020 Jul 15; Vol. 253, pp. 117725. Date of Electronic Publication: 2020 Apr 27.
Typ publikacji :
Comparative Study; Journal Article
Journal Info :
Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0631 (Electronic) Linking ISSN: 00243205 NLM ISO Abbreviation: Life Sci. Subsets: MEDLINE
MeSH Terms :
Exenatide/*pharmacology
Hypoglycemic Agents/*pharmacology
Inflammation/*drug therapy
Non-alcoholic Fatty Liver Disease/*drug therapy
Animals ; Body Weight/drug effects ; Diet, High-Fat ; Disease Progression ; Dose-Response Relationship, Drug ; Exenatide/administration & dosage ; Hypoglycemic Agents/administration & dosage ; Inflammation/pathology ; Insulin Resistance ; Male ; Metformin/pharmacology ; NF-kappa B/metabolism ; Non-alcoholic Fatty Liver Disease/pathology ; Rats ; Rats, Wistar ; Signal Transduction/drug effects ; Toll-Like Receptor 4/metabolism
Czasopismo naukowe
Tytuł :
Design and characterization of novel oxyntomodulin derivatives with potent dual GLP-1/glucagon receptor activation and prolonged antidiabetic effects.
Autorzy :
Pei Z; College of Animal Sciences, Zhejiang University, Hangzhou 310058, PR China; Hangzhou RunChongGuiMei Bio-tech Co., Ltd., Xiao Shan, Hangzhou 310058, PR China. Electronic address: .
Zhou D; National Research Center for Veterinary Medicine, Road Cuiwei, High-Tech District, Luoyang 471003, PR China.
Yan J; Suzhou Xishan Zhongke Drug R&D Co., Ltd., Wuzhong Avenue, Suzhou 215000, PR China.
Wang S; College of Animal Sciences, Zhejiang University, Hangzhou 310058, PR China.
Yang X; Hangzhou RunChongGuiMei Bio-tech Co., Ltd., Xiao Shan, Hangzhou 310058, PR China.
Pei Z; Hangzhou RunChongGuiMei Bio-tech Co., Ltd., Xiao Shan, Hangzhou 310058, PR China.
Pokaż więcej
Źródło :
Life sciences [Life Sci] 2020 Jul 15; Vol. 253, pp. 117651. Date of Electronic Publication: 2020 Apr 15.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0631 (Electronic) Linking ISSN: 00243205 NLM ISO Abbreviation: Life Sci. Subsets: MEDLINE
MeSH Terms :
Glucagon-Like Peptide-1 Receptor/*metabolism
Hypoglycemic Agents/*chemistry
Oxyntomodulin/*chemistry
Receptors, Glucagon/*metabolism
Animals ; Blood Glucose/drug effects ; Diabetes Mellitus/metabolism ; Dimerization ; Glucagon/metabolism ; Glucose Tolerance Test ; Hypoglycemic Agents/pharmacokinetics ; Macaca fascicularis ; Male ; Mice ; Mice, Knockout ; Mice, Obese ; Obesity/metabolism ; Oxyntomodulin/pharmacokinetics ; Polyethylene Glycols/chemistry ; Rats, Sprague-Dawley ; Solid-Phase Synthesis Techniques ; Weight Loss/drug effects
Czasopismo naukowe
Tytuł :
An Assessment of Glycaemic Control and Modes of Health Financing among Type 2 Diabetic Patients Attending a Teaching Hospital in South-western Nigeria.
Autorzy :
Attoye TE; Department of Family Medicine, Lagos University Teaching Hospital, Idi-Araba, Lagos, Nigeria.
Adebobola PA; Department of Family Medicine, Lagos University Teaching Hospital, Idi-Araba, Lagos, Nigeria.
Inem V; Department of Community Health and Primary Care, College of Medicine University of Lagos, Nigeria.
Pokaż więcej
Źródło :
West African journal of medicine [West Afr J Med] 2020 Jul-Aug; Vol. 37 (3), pp. 237-247.
Typ publikacji :
Journal Article
Journal Info :
Publisher: West African College Of Physicians And West African College Of Surgeons Country of Publication: Nigeria NLM ID: 8301891 Publication Model: Print Cited Medium: Print ISSN: 0189-160X (Print) Linking ISSN: 0189160X NLM ISO Abbreviation: West Afr J Med Subsets: MEDLINE
MeSH Terms :
Blood Glucose/*metabolism
Diabetes Mellitus, Type 2/*drug therapy
Financing, Personal/*economics
Health Expenditures/*statistics & numerical data
Hypoglycemic Agents/*administration & dosage
Insulin/*administration & dosage
Adult ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/economics ; Female ; Financing, Personal/statistics & numerical data ; Glycated Hemoglobin A/analysis ; Hospitals, Teaching ; Humans ; Hypoglycemic Agents/economics ; Insulin/economics ; Male ; Middle Aged ; Nigeria ; Socioeconomic Factors
Czasopismo naukowe
Tytuł :
Biometrics and citizenship: Measuring diabetes in the United States in the interwar years.
Autorzy :
Tuchman AM; Vanderbilt University, Nashville, USA.
Pokaż więcej
Źródło :
History of science; an annual review of literature, research and teaching [Hist Sci] 2020 Jul; Vol. 58 (2), pp. 166-190. Date of Electronic Publication: 2019 Sep 13.
Typ publikacji :
Historical Article; Journal Article; Research Support, N.I.H., Extramural
Journal Info :
Publisher: Sage Country of Publication: United States NLM ID: 17340520R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1753-8564 (Electronic) Linking ISSN: 00732753 NLM ISO Abbreviation: Hist Sci Subsets: Non-Index Medicus History of Medicine
MeSH Terms :
Diabetes Mellitus/*history
Hypoglycemic Agents/*history
Insulin/*history
Medical Writing/*history
Self Care/*history
Diabetes Mellitus/diet therapy ; Exercise ; Female ; History, 20th Century ; Humans ; Hypoglycemic Agents/therapeutic use ; Insulin/therapeutic use ; Male ; Patient Compliance ; United States ; Urinalysis/history
Czasopismo naukowe
Tytuł :
Is the type of diabetes treatment relevant to outcome of COVID-19?
Autorzy :
Bloomgarden Z; Department of Medicine, Division of Endocrinology, Diabetes, and Bone Disease, Icahn School of Medicine at Mount Sinai, New York, New York.
Pokaż więcej
Źródło :
Journal of diabetes [J Diabetes] 2020 Jul; Vol. 12 (7), pp. 486-487.
Typ publikacji :
Editorial
Journal Info :
Publisher: Blackwell Publishing Asia Country of Publication: Australia NLM ID: 101504326 Publication Model: Print Cited Medium: Internet ISSN: 1753-0407 (Electronic) Linking ISSN: 17530407 NLM ISO Abbreviation: J Diabetes Subsets: MEDLINE
MeSH Terms :
Anti-Inflammatory Agents/*therapeutic use
Antiviral Agents/*therapeutic use
Betacoronavirus/*drug effects
Coronavirus Infections/*drug therapy
Diabetes Mellitus, Type 2/*drug therapy
Hypoglycemic Agents/*therapeutic use
Pneumonia, Viral/*drug therapy
Anti-Inflammatory Agents/adverse effects ; Antiviral Agents/adverse effects ; Betacoronavirus/pathogenicity ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Coronavirus Infections/virology ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/epidemiology ; Host-Pathogen Interactions ; Humans ; Hypoglycemic Agents/adverse effects ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/virology ; Risk Factors ; Treatment Outcome
SCR Disease Name :
COVID-19
SCR Protocol :
COVID-19 drug treatment
SCR Organism :
severe acute respiratory syndrome coronavirus 2
Opinia redakcyjna
Tytuł :
Effect of Continuous Glucose Monitoring on Glycemic Control in Adolescents and Young Adults With Type 1 Diabetes: A Randomized Clinical Trial.
Autorzy :
Laffel LM; Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts.
Kanapka LG; Jaeb Center for Health Research, Tampa, Florida.
Beck RW; Jaeb Center for Health Research, Tampa, Florida.
Bergamo K; University of North Carolina Diabetes Care Center, Chapel Hill.
Clements MA; Children's Mercy Hospital, Kansas City, Missouri.
Criego A; Health Partners Institute, International Diabetes Center, St Louis Park, Minnesota.
DeSalvo DJ; Baylor College of Medicine, Houston, Texas.
Goland R; Naomi Berrie Diabetes Center, Columbia University, New York, New York.
Hood K; Stanford University, Palo Alto, California.
Liljenquist D; Rocky Mountain Diabetes & Osteoporosis Center, Idaho Falls, Idaho.
Messer LH
Monzavi R; Children's Hospital Los Angeles, Los Angeles, California.
Mouse TJ; Jaeb Center for Health Research, Tampa, Florida.
Prahalad P; Stanford University, Palo Alto, California.
Sherr J; Yale Children's Diabetes Program, New Haven, Connecticut.
Simmons JH; Vanderbilt University Medical Center, Nashville, Tennessee.
Wadwa RP; Barbara Davis Center for Childhood Diabetes, Aurora, Colorado.
Weinstock RS; SUNY Upstate Medical University, Syracuse, New York.
Willi SM; Childrens Hospital of Philadelphia, Philadelphia, Pennsylvania.
Miller KM; Jaeb Center for Health Research, Tampa, Florida.
Pokaż więcej
Corporate Authors :
CGM Intervention in Teens and Young Adults with T1D (CITY) Study Group
CDE10
Źródło :
JAMA [JAMA] 2020 Jun 16; Vol. 323 (23), pp. 2388-2396.
Typ publikacji :
Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial
Journal Info :
Publisher: American Medical Association Country of Publication: United States NLM ID: 7501160 Publication Model: Print Cited Medium: Internet ISSN: 1538-3598 (Electronic) Linking ISSN: 00987484 NLM ISO Abbreviation: JAMA Subsets: Core Clinical (AIM); MEDLINE
MeSH Terms :
Blood Glucose Self-Monitoring/*methods
Diabetes Mellitus, Type 1/*blood
Glycated Hemoglobin A/*analysis
Hypoglycemic Agents/*administration & dosage
Adolescent ; Blood Glucose/analysis ; Blood Glucose Self-Monitoring/instrumentation ; Diabetes Mellitus, Type 1/drug therapy ; Diabetic Ketoacidosis ; Female ; Humans ; Hyperglycemia/diagnosis ; Hyperglycemia/prevention & control ; Hypoglycemia/chemically induced ; Hypoglycemia/diagnosis ; Hypoglycemia/prevention & control ; Hypoglycemic Agents/adverse effects ; Male ; Mobile Applications ; Monitoring, Ambulatory/instrumentation ; Young Adult
Czasopismo naukowe
Tytuł :
Release of antidiabetic peptides from Stichopus japonicas by simulated gastrointestinal digestion.
Autorzy :
Gong PX; School of Marine Science and Technology, Harbin Institute of Technology, Weihai 264209, PR China.
Wang BK; School of Marine Science and Technology, Harbin Institute of Technology, Weihai 264209, PR China.
Wu YC; School of Marine Science and Technology, Harbin Institute of Technology, Weihai 264209, PR China. Electronic address: .
Li QY; School of Marine Science and Technology, Harbin Institute of Technology, Weihai 264209, PR China.
Qin BW; Shandong Shengzhou Marine Biotech. Co., Ltd., Weihai 264211, PR China.
Li HJ; School of Marine Science and Technology, Harbin Institute of Technology, Weihai 264209, PR China; Weihai Institute of Marine Biomedical Industrial Technology, Wendeng District, Weihai 264400, PR China. Electronic address: .
Pokaż więcej
Źródło :
Food chemistry [Food Chem] 2020 Jun 15; Vol. 315, pp. 126273. Date of Electronic Publication: 2020 Jan 21.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE
MeSH Terms :
Hypoglycemic Agents/*pharmacology
Peptides/*analysis
Peptides/*pharmacology
Stichopus/*chemistry
3T3-L1 Cells ; Animals ; Chromatography, Liquid ; Digestion ; Dipeptidyl Peptidase 4/chemistry ; Dipeptidyl Peptidase 4/metabolism ; Dipeptidyl-Peptidase IV Inhibitors/chemistry ; Dipeptidyl-Peptidase IV Inhibitors/pharmacology ; Hep G2 Cells ; Humans ; Hydrolysis ; Hypoglycemic Agents/metabolism ; Mice ; Molecular Docking Simulation ; Peptides/chemistry ; Stichopus/metabolism ; Tandem Mass Spectrometry
Czasopismo naukowe
Tytuł :
Practical recommendations for the management of diabetes in patients with COVID-19.
Autorzy :
Bornstein SR; Department of Medicine III, University Hospital Carl Gustav Carus, Dresden, Germany; Paul Langerhans Institute Dresden of the Helmholtz Center Munich, University Hospital Carl Gustav Carus, Dresden, Germany; Department of Diabetes, School of Life Course Science and Medicine, King's College London, London, UK; Department of Endocrinology and Diabetology, University Hospital Zurich, Zurich, Switzerland; Faculty of Medicine, Technische Universität Dresden, Dresden, Germany; German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany. Electronic address: .
Rubino F; Department of Diabetes, School of Life Course Science and Medicine, King's College London, London, UK; Bariatric and Metabolic Surgery, King's College Hospital, London, UK.
Khunti K; Diabetes Research Centre, University of Leicester, Leicester, UK.
Mingrone G; Department of Diabetes, School of Life Course Science and Medicine, King's College London, London, UK; Fondazione Policlinico Universitario Agostino Gemelli Istituto Di Ricovero e Cura a Carattere Scientifico, Rome, Italy; Department of Internal Medicine, Università Cattolica del Sacro Cuore, Rome, Italy.
Hopkins D; Department of Diabetes, School of Life Course Science and Medicine, King's College London, London, UK; Institute of Diabetes Endocrinology and Obesity, King's Health Partners, London, UK.
Birkenfeld AL; Department of Diabetes, School of Life Course Science and Medicine, King's College London, London, UK; German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany; Department of Diabetology, Endocrinology and Nephrology, University Hospital Tübingen, Tübingen, Germany; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen, Tübingen, Germany.
Boehm B; Department of Endocrinology, Tan Tock Seng Hospital, Singapore, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore.
Amiel S; Department of Diabetes, School of Life Course Science and Medicine, King's College London, London, UK.
Holt RI; Human Development and Health, Faculty of Medicine, University of Southampton, UK.
Skyler JS; Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
DeVries JH; Department of Endocrinology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands; Profil Institute for Metabolic Research, Neuss, Germany.
Renard E; Montpellier University Hospital and Institute of Functional Genomics, Centre national de la recherche scientifique, INSERM, University of Montpellier, Montpellier, France.
Eckel RH; Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Zimmet P; Department of Diabetes, Central Clinical School, Monash University, Melbourne, VIC, Australia.
Alberti KG; Division of Diabetes, Endocrinology and Metabolism, Imperial College, London, UK.
Vidal J; Centro de Investigación Biomédica en Red en Diabetes y Enfermedades Metabólicas Asociadas, Barcelona, Spain.
Geloneze B; Obesity and Comorbities Research Center, Laboratory of Investigation in Metabolism and Diabetes/Gastrocentro, Universidade de Campinas, Campinas, São Paulo, Brazil.
Chan JC; Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity and Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong Special Administrative Region, China.
Ji L; Department of Endocrinology and Metabolism, Peking University People's Hospital, Peking University Diabetes Center, Beijing, China.
Ludwig B; Department of Medicine III, University Hospital Carl Gustav Carus, Dresden, Germany; Paul Langerhans Institute Dresden of the Helmholtz Center Munich, University Hospital Carl Gustav Carus, Dresden, Germany; Department of Endocrinology and Diabetology, University Hospital Zurich, Zurich, Switzerland; Faculty of Medicine, Technische Universität Dresden, Dresden, Germany; Deutsche Forschungsgemeinschaft-Center for Regenerative Therapies Dresden, Technische Universität Dresden, Dresden, Germany; German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany.
Pokaż więcej
Źródło :
The lancet. Diabetes & endocrinology [Lancet Diabetes Endocrinol] 2020 Jun; Vol. 8 (6), pp. 546-550. Date of Electronic Publication: 2020 Apr 23.
Typ publikacji :
Journal Article; Review
Journal Info :
Publisher: The Lancet, Diabetes & Endocrinology Country of Publication: England NLM ID: 101618821 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-8595 (Electronic) Linking ISSN: 22138587 NLM ISO Abbreviation: Lancet Diabetes Endocrinol Subsets: MEDLINE
MeSH Terms :
Pandemics*
Betacoronavirus/*pathogenicity
Coronavirus Infections/*physiopathology
Diabetes Mellitus, Type 1/*drug therapy
Diabetes Mellitus, Type 2/*drug therapy
Hypoglycemic Agents/*adverse effects
Pneumonia, Viral/*physiopathology
Comorbidity ; Contraindications, Drug ; Coronavirus Infections/therapy ; Diabetes Mellitus, Type 1/physiopathology ; Diabetes Mellitus, Type 2/physiopathology ; Humans ; Hypoglycemic Agents/administration & dosage ; Multiple Organ Failure/chemically induced ; Multiple Organ Failure/physiopathology ; Pneumonia, Viral/therapy ; Practice Guidelines as Topic ; Respiratory Distress Syndrome, Adult/chemically induced ; Respiratory Distress Syndrome, Adult/physiopathology
SCR Disease Name :
COVID-19
SCR Organism :
severe acute respiratory syndrome coronavirus 2
Czasopismo naukowe
Tytuł :
C-glucosidic ellagitannins and galloylated glucoses as potential functional food ingredients with anti-diabetic properties: a study of α-glucosidase and α-amylase inhibition.
Autorzy :
Cardullo N; Dipartimento di Scienze Chimiche, Università degli Studi di Catania, Viale A. Doria 6, 95125 Catania, Italy. Electronic address: .
Muccilli V; Dipartimento di Scienze Chimiche, Università degli Studi di Catania, Viale A. Doria 6, 95125 Catania, Italy. Electronic address: .
Pulvirenti L; Dipartimento di Scienze Chimiche, Università degli Studi di Catania, Viale A. Doria 6, 95125 Catania, Italy. Electronic address: .
Cornu A; Univ. Bordeaux, Institut des Sciences Moléculaires (UMR-CNRS 5255), 351 cours de la Libération, 33405 Talence Cedex, France. Electronic address: .
Pouységu L; Univ. Bordeaux, Institut des Sciences Moléculaires (UMR-CNRS 5255), 351 cours de la Libération, 33405 Talence Cedex, France. Electronic address: .
Deffieux D; Univ. Bordeaux, Institut des Sciences Moléculaires (UMR-CNRS 5255), 351 cours de la Libération, 33405 Talence Cedex, France. Electronic address: .
Quideau S; Univ. Bordeaux, Institut des Sciences Moléculaires (UMR-CNRS 5255), 351 cours de la Libération, 33405 Talence Cedex, France; Institut Universitaire de France, 1 rue Descartes, 75231 Paris Cedex 05, France. Electronic address: .
Tringali C; Dipartimento di Scienze Chimiche, Università degli Studi di Catania, Viale A. Doria 6, 95125 Catania, Italy. Electronic address: .
Pokaż więcej
Źródło :
Food chemistry [Food Chem] 2020 May 30; Vol. 313, pp. 126099. Date of Electronic Publication: 2019 Dec 28.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE
MeSH Terms :
Hydrolyzable Tannins/*chemistry
Hypoglycemic Agents/*chemistry
alpha-Amylases/*metabolism
alpha-Glucosidases/*metabolism
Circular Dichroism ; Glucosides/chemistry ; Hydrolyzable Tannins/metabolism ; Hypoglycemic Agents/metabolism ; Inhibitory Concentration 50 ; Kinetics ; Spectrometry, Fluorescence ; alpha-Amylases/antagonists & inhibitors ; alpha-Glucosidases/chemistry
Czasopismo naukowe
Tytuł :
Potential Benefits and Harms of Novel Antidiabetic Drugs During COVID-19 Crisis.
Autorzy :
Mirabelli M; Department of Health Sciences, University 'Magna Graecia' of Catanzaro, Viale Europa, 88100 Catanzaro, Italy.
Chiefari E; Department of Health Sciences, University 'Magna Graecia' of Catanzaro, Viale Europa, 88100 Catanzaro, Italy.
Puccio L; Complex Operative Unit of Endocrinology and Diabetes, Hospital Pugliese-Ciaccio, 88100 Catanzaro, Italy.
Foti DP; Department of Health Sciences, University 'Magna Graecia' of Catanzaro, Viale Europa, 88100 Catanzaro, Italy.
Brunetti A; Department of Health Sciences, University 'Magna Graecia' of Catanzaro, Viale Europa, 88100 Catanzaro, Italy.
Pokaż więcej
Źródło :
International journal of environmental research and public health [Int J Environ Res Public Health] 2020 May 22; Vol. 17 (10). Date of Electronic Publication: 2020 May 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: MDPI Country of Publication: Switzerland NLM ID: 101238455 Publication Model: Electronic Cited Medium: Internet ISSN: 1660-4601 (Electronic) Linking ISSN: 16604601 NLM ISO Abbreviation: Int J Environ Res Public Health Subsets: MEDLINE
MeSH Terms :
Pandemics*
Betacoronavirus/*isolation & purification
Coronavirus Infections/*physiopathology
Hypoglycemic Agents/*therapeutic use
Pneumonia, Viral/*physiopathology
Blood Glucose ; Coronavirus Infections/epidemiology ; Coronavirus Infections/virology ; Diabetes Mellitus ; Humans ; Hypoglycemic Agents/adverse effects ; Insulin ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/virology
SCR Disease Name :
COVID-19
SCR Organism :
severe acute respiratory syndrome coronavirus 2
Czasopismo naukowe
Tytuł :
Metformin use in hidradenitis suppurativa.
Autorzy :
Jennings L; The Charles Centre, Department of Dermatology, St Vincent's University Hospital, Dublin, Ireland.
Hambly R; The Charles Centre, Department of Dermatology, St Vincent's University Hospital, Dublin, Ireland.; School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland.; Wellcome-Health Research Board, Irish Clinical Academic Training (ICAT), Dublin, Ireland.
Hughes R; The Charles Centre, Department of Dermatology, St Vincent's University Hospital, Dublin, Ireland.
Moriarty B; The Charles Centre, Department of Dermatology, St Vincent's University Hospital, Dublin, Ireland.
Kirby B; The Charles Centre, Department of Dermatology, St Vincent's University Hospital, Dublin, Ireland.; School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland.; Charles Institute of Dermatology, University College Dublin, Dublin, Ireland.
Pokaż więcej
Źródło :
The Journal of dermatological treatment [J Dermatolog Treat] 2020 May; Vol. 31 (3), pp. 261-263. Date of Electronic Publication: 2019 Mar 25.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Informa Healthcare Country of Publication: England NLM ID: 8918133 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1471-1753 (Electronic) Linking ISSN: 09546634 NLM ISO Abbreviation: J Dermatolog Treat Subsets: MEDLINE
MeSH Terms :
Hidradenitis Suppurativa/*drug therapy
Hypoglycemic Agents/*therapeutic use
Metformin/*therapeutic use
Adult ; Female ; Gastrointestinal Diseases/etiology ; Hidradenitis Suppurativa/pathology ; Humans ; Hypoglycemic Agents/adverse effects ; Male ; Metformin/adverse effects ; Middle Aged ; Retrospective Studies ; Severity of Illness Index ; Treatment Outcome ; Young Adult
Czasopismo naukowe
Tytuł :
SARS-CoV-2 and DPP4 inhibition: Is it time to pray for Janus Bifrons?
Autorzy :
Pitocco D; Diabetes Care Unit, Fondazione Policlinico A. Gemelli IRCCS, Rome, Italy. Electronic address: .
Tartaglione L; Diabetes Care Unit, Fondazione Policlinico A. Gemelli IRCCS, Rome, Italy.
Viti L; Diabetes Care Unit, Fondazione Policlinico A. Gemelli IRCCS, Rome, Italy.
Di Leo M; Diabetes Care Unit, Fondazione Policlinico A. Gemelli IRCCS, Rome, Italy.
Pontecorvi A; Department of Endocrinology, Fondazione Policlinico A. Gemelli IRCCS, Rome, Italy.
Caputo S; Diabetes Care Unit, Fondazione Policlinico A. Gemelli IRCCS, Rome, Italy.
Pokaż więcej
Źródło :
Diabetes research and clinical practice [Diabetes Res Clin Pract] 2020 May; Vol. 163, pp. 108162. Date of Electronic Publication: 2020 Apr 23.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Elsevier Scientific Publishers Country of Publication: Ireland NLM ID: 8508335 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8227 (Electronic) Linking ISSN: 01688227 NLM ISO Abbreviation: Diabetes Res. Clin. Pract. Subsets: MEDLINE
MeSH Terms :
Coronavirus Infections/*drug therapy
Diabetes Mellitus, Type 2/*drug therapy
Dipeptidyl Peptidase 4/*metabolism
Dipeptidyl-Peptidase IV Inhibitors/*therapeutic use
Hypoglycemic Agents/*therapeutic use
Pneumonia, Viral/*drug therapy
Dipeptidyl-Peptidase IV Inhibitors/pharmacology ; Humans ; Hypoglycemic Agents/pharmacology ; Pandemics
SCR Disease Name :
COVID-19
Czasopismo naukowe
Tytuł :
Studies on characteristics and anti-diabetic and -nephritic effects of polysaccharides isolated from Paecilomyces hepiali fermentation mycelium in db/db mice.
Autorzy :
Hu W; School of Life Sciences, Jilin University, Changchun,130012, China. Electronic address: .
Wang J; School of Life Sciences, Jilin University, Changchun,130012, China; Academy of Science, Liaoning University, Shenyang, 110031, China. Electronic address: .
Guo W; Department of Endocrine and Metabolism, The First Hospital of Jilin University, Jilin University, Changchun, 130021, China. Electronic address: .
Liu Y; School of Life Sciences, Jilin University, Changchun,130012, China. Electronic address: .
Guo Z; School of Life Sciences, Jilin University, Changchun,130012, China. Electronic address: .
Miao Y; School of Life Sciences, Jilin University, Changchun,130012, China. Electronic address: .
Wang D; School of Life Sciences, Jilin University, Changchun,130012, China. Electronic address: .
Pokaż więcej
Źródło :
Carbohydrate polymers [Carbohydr Polym] 2020 Mar 15; Vol. 232, pp. 115766. Date of Electronic Publication: 2019 Dec 20.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 8307156 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1344 (Electronic) Linking ISSN: 01448617 NLM ISO Abbreviation: Carbohydr Polym Subsets: MEDLINE
MeSH Terms :
Diabetes Mellitus, Type 2/*drug therapy
Diabetic Nephropathies/*drug therapy
Hypoglycemic Agents/*therapeutic use
Mycelium/*chemistry
Polysaccharides/*therapeutic use
Animals ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/metabolism ; Diabetes Mellitus, Type 2/metabolism ; Diabetic Nephropathies/metabolism ; Disease Models, Animal ; Fermentation ; Hypoglycemic Agents/chemistry ; Hypoglycemic Agents/isolation & purification ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Mycelium/metabolism ; NF-kappa B/antagonists & inhibitors ; NF-kappa B/metabolism ; Particle Size ; Polysaccharides/chemistry ; Polysaccharides/isolation & purification ; Signal Transduction/drug effects ; Surface Properties
Czasopismo naukowe
Tytuł :
A Novel Acetyl-CoA Carboxylase 2 Selective Inhibitor Improves Whole-Body Insulin Resistance and Hyperglycemia in Diabetic Mice through Target-Dependent Pathways.
Autorzy :
Takagi H; Shionogi & Co., Ltd., Osaka, Japan (H.T., K.T., A.S., Y.T., S.M., K.A., M.N., H.Y.) and Shionogi Techno Advance Research Co., Ltd., Osaka, Japan (S.S.) .
Tanimoto K; Shionogi & Co., Ltd., Osaka, Japan (H.T., K.T., A.S., Y.T., S.M., K.A., M.N., H.Y.) and Shionogi Techno Advance Research Co., Ltd., Osaka, Japan (S.S.).
Shimazaki A; Shionogi & Co., Ltd., Osaka, Japan (H.T., K.T., A.S., Y.T., S.M., K.A., M.N., H.Y.) and Shionogi Techno Advance Research Co., Ltd., Osaka, Japan (S.S.).
Tonomura Y; Shionogi & Co., Ltd., Osaka, Japan (H.T., K.T., A.S., Y.T., S.M., K.A., M.N., H.Y.) and Shionogi Techno Advance Research Co., Ltd., Osaka, Japan (S.S.).
Momosaki S; Shionogi & Co., Ltd., Osaka, Japan (H.T., K.T., A.S., Y.T., S.M., K.A., M.N., H.Y.) and Shionogi Techno Advance Research Co., Ltd., Osaka, Japan (S.S.).
Sakamoto S; Shionogi & Co., Ltd., Osaka, Japan (H.T., K.T., A.S., Y.T., S.M., K.A., M.N., H.Y.) and Shionogi Techno Advance Research Co., Ltd., Osaka, Japan (S.S.).
Abe K; Shionogi & Co., Ltd., Osaka, Japan (H.T., K.T., A.S., Y.T., S.M., K.A., M.N., H.Y.) and Shionogi Techno Advance Research Co., Ltd., Osaka, Japan (S.S.).
Notoya M; Shionogi & Co., Ltd., Osaka, Japan (H.T., K.T., A.S., Y.T., S.M., K.A., M.N., H.Y.) and Shionogi Techno Advance Research Co., Ltd., Osaka, Japan (S.S.).
Yukioka H; Shionogi & Co., Ltd., Osaka, Japan (H.T., K.T., A.S., Y.T., S.M., K.A., M.N., H.Y.) and Shionogi Techno Advance Research Co., Ltd., Osaka, Japan (S.S.).
Pokaż więcej
Źródło :
The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2020 Mar; Vol. 372 (3), pp. 256-263. Date of Electronic Publication: 2020 Jan 03.
Typ publikacji :
Journal Article
Journal Info :
Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0103 (Electronic) Linking ISSN: 00223565 NLM ISO Abbreviation: J. Pharmacol. Exp. Ther. Subsets: MEDLINE
MeSH Terms :
Insulin Resistance*
Acetyl-CoA Carboxylase/*antagonists & inhibitors
Diabetes Mellitus, Experimental/*drug therapy
Diabetes Mellitus, Type 2/*drug therapy
Hyperglycemia/*prevention & control
Hypoglycemic Agents/*therapeutic use
Acetyl-CoA Carboxylase/genetics ; Animals ; Blood Glucose/analysis ; Diabetes Mellitus, Experimental/blood ; Diabetes Mellitus, Type 2/blood ; Hypoglycemic Agents/pharmacokinetics ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/toxicity ; Insulin/metabolism ; Mice, Knockout ; Muscle, Skeletal/enzymology ; Pancreas/drug effects ; Pancreas/metabolism ; Rats, Sprague-Dawley ; Toxicity Tests ; Triglycerides/blood
Czasopismo naukowe
Tytuł :
Lipid-Based Gliclazide Nanoparticles for Treatment of Diabetes: Formulation, Pharmacokinetics, Pharmacodynamics and Subacute Toxicity Study.
Autorzy :
Nazief AM; Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.
Hassaan PS; Department of Medical Physiology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Khalifa HM; Department of Histology and Cell Biology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Sokar MS; Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.
El-Kamel AH; Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.
Pokaż więcej
Źródło :
International journal of nanomedicine [Int J Nanomedicine] 2020 Feb 18; Vol. 15, pp. 1129-1148. Date of Electronic Publication: 2020 Feb 18 (Print Publication: 2020).
Typ publikacji :
Journal Article
Journal Info :
Publisher: DOVE Medical Press Country of Publication: New Zealand NLM ID: 101263847 Publication Model: eCollection Cited Medium: Internet ISSN: 1178-2013 (Electronic) Linking ISSN: 11769114 NLM ISO Abbreviation: Int J Nanomedicine Subsets: MEDLINE
MeSH Terms :
Gliclazide/*pharmacokinetics
Hypoglycemic Agents/*pharmacokinetics
Nanoparticles/*administration & dosage
Administration, Oral ; Animals ; Biological Availability ; Diabetes Mellitus, Experimental/drug therapy ; Drug Liberation ; Fatty Acids/chemistry ; Freeze Drying ; Gliclazide/administration & dosage ; Gliclazide/toxicity ; Hypoglycemic Agents/administration & dosage ; Hypoglycemic Agents/toxicity ; Lipids/chemistry ; Male ; Nanoparticles/chemistry ; Particle Size ; Poloxamer/chemistry ; Rats, Wistar ; Solubility ; Tablets/chemistry ; Toxicity Tests, Subacute
Czasopismo naukowe
Tytuł :
Protective properties of mesocellular silica foams against aggregation and enzymatic hydrolysis of loaded proteins for oral protein delivery.
Autorzy :
He Y; Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
Wang M; Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
Zhang H; Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China.
Zhang Y; Department of Pharmacy, The Fourth Affiliated Hospital of China Medical University, Shenyang 110032, China.
Gao Y; School of Medical Devices, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: .
Wang S; Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: .
Pokaż więcej
Źródło :
Journal of colloid and interface science [J Colloid Interface Sci] 2020 Feb 15; Vol. 560, pp. 690-700. Date of Electronic Publication: 2019 Nov 01.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Academic Press Country of Publication: United States NLM ID: 0043125 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-7103 (Electronic) Linking ISSN: 00219797 NLM ISO Abbreviation: J Colloid Interface Sci Subsets: MEDLINE
MeSH Terms :
Drug Delivery Systems*
Diabetes Mellitus, Experimental/*drug therapy
Drug Carriers/*chemistry
Hypoglycemic Agents/*administration & dosage
Insulin/*administration & dosage
Nanoparticles/*administration & dosage
Silicon Dioxide/*chemistry
Administration, Oral ; Animals ; Enzymes/metabolism ; Hydrolysis ; Hypoglycemic Agents/chemistry ; Hypoglycemic Agents/metabolism ; Insulin/chemistry ; Insulin/metabolism ; Male ; Mice ; Nanoparticles/chemistry ; Protective Agents/chemistry ; Protein Aggregates ; Protein Conformation ; Proteolysis
Czasopismo naukowe
Tytuł :
Synthesis and discovery of triazolo-pyridazine-6-yl-substituted piperazines as effective anti-diabetic drugs; evaluated over dipeptidyl peptidase-4 inhibition mechanism and insulinotropic activities.
Autorzy :
Bindu B; Dept. of Chemistry, Government Arts College, Coimbatore, 641018, Tamil Nadu, India.
Vijayalakshmi S; Dept. of Chemistry, Government Arts College, Coimbatore, 641018, Tamil Nadu, India.
Manikandan A; Dept. of Biotech, School of Biosciences and Technology, VIT University, Vellore, 632014, Tamil Nadu, India. Electronic address: .
Pokaż więcej
Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2020 Feb 01; Vol. 187, pp. 111912. Date of Electronic Publication: 2019 Nov 30.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE
MeSH Terms :
Diabetes Mellitus/*drug therapy
Dipeptidyl Peptidase 4/*metabolism
Dipeptidyl-Peptidase IV Inhibitors/*pharmacology
Hypoglycemic Agents/*pharmacology
Insulin/*metabolism
Piperazines/*pharmacology
Diabetes Mellitus/metabolism ; Dipeptidyl-Peptidase IV Inhibitors/chemical synthesis ; Dipeptidyl-Peptidase IV Inhibitors/chemistry ; Dose-Response Relationship, Drug ; Drug Discovery ; Humans ; Hypoglycemic Agents/chemical synthesis ; Hypoglycemic Agents/chemistry ; Molecular Structure ; Piperazines/chemical synthesis ; Piperazines/chemistry ; Pyridazines/chemistry ; Pyridazines/pharmacology ; Structure-Activity Relationship ; Triazoles/chemistry ; Triazoles/pharmacology
Czasopismo naukowe
Tytuł :
The rollercoaster history of using physiological and pharmacological properties of incretin hormones to develop diabetes medications with a convincing benefit-risk relationship.
Autorzy :
Nauck MA; Diabetes Division, Katholisches Klinikum Bochum, St. Josef Hospital (Ruhr-University Bochum), Gudrunstr. 56, 44791 Bochum, Germany. Electronic address: .
Pokaż więcej
Źródło :
Metabolism: clinical and experimental [Metabolism] 2020 Feb; Vol. 103, pp. 154031. Date of Electronic Publication: 2019 Nov 28.
Typ publikacji :
Historical Article; Journal Article
Journal Info :
Publisher: W.B. Saunders Country of Publication: United States NLM ID: 0375267 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-8600 (Electronic) Linking ISSN: 00260495 NLM ISO Abbreviation: Metab. Clin. Exp. Subsets: MEDLINE
MeSH Terms :
Diabetes Mellitus/*drug therapy
Drug Development/*history
Hypoglycemic Agents/*chemical synthesis
Incretins/*pharmacology
Incretins/*physiology
Biomedical Research/history ; Diabetes Mellitus/epidemiology ; Diabetes Mellitus/history ; Drug Development/methods ; Drug Industry/history ; Drug-Related Side Effects and Adverse Reactions/epidemiology ; History, 20th Century ; History, 21st Century ; Humans ; Hypoglycemic Agents/history ; Hypoglycemic Agents/therapeutic use ; Incretins/history ; Risk Assessment
Czasopismo naukowe
Tytuł :
Beneficial effects of ferulic acid alone and in combination with insulin in streptozotocin induced diabetic neuropathy in Sprague Dawley rats.
Autorzy :
Dhaliwal J; Pharmacology Division, University Institute of Pharmaceutical Sciences (UIPS), Panjab University, Chandigarh 160014, India.
Dhaliwal N; Pharmacology Division, University Institute of Pharmaceutical Sciences (UIPS), Panjab University, Chandigarh 160014, India.
Akhtar A; Pharmacology Division, University Institute of Pharmaceutical Sciences (UIPS), Panjab University, Chandigarh 160014, India.
Kuhad A; Pharmacology Division, University Institute of Pharmaceutical Sciences (UIPS), Panjab University, Chandigarh 160014, India.
Chopra K; Pharmacology Division, University Institute of Pharmaceutical Sciences (UIPS), Panjab University, Chandigarh 160014, India. Electronic address: .
Pokaż więcej
Źródło :
Life sciences [Life Sci] 2020 Aug 15; Vol. 255, pp. 117856. Date of Electronic Publication: 2020 May 28.
Typ publikacji :
Comparative Study; Journal Article
Journal Info :
Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0631 (Electronic) Linking ISSN: 00243205 NLM ISO Abbreviation: Life Sci. Subsets: MEDLINE
MeSH Terms :
Coumaric Acids/*pharmacology
Diabetes Mellitus, Experimental/*drug therapy
Diabetic Neuropathies/*drug therapy
Hypoglycemic Agents/*pharmacology
Insulin/*pharmacology
Animals ; Antioxidants/metabolism ; Blood Glucose/drug effects ; Coumaric Acids/administration & dosage ; Diabetes Mellitus, Experimental/physiopathology ; Diabetic Neuropathies/physiopathology ; Dose-Response Relationship, Drug ; Drug Therapy, Combination ; Hypoglycemic Agents/administration & dosage ; Insulin/administration & dosage ; Male ; Oxidative Stress/drug effects ; Rats ; Rats, Sprague-Dawley ; Streptozocin
Czasopismo naukowe

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies