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Podgląd okładki
Tytuł :
Bioassay-guided fractionation and identification of antidiabetic compounds from the rind of Punica Granatum Var. nana.
Autorzy :
El Deeb KS; Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Eid HH; Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Ali ZY; Department of Biochemistry, National Organization for Drug Control & Research (NODCAR), Giza, Egypt.
Shams MM; Department of Medicinal plants and natural products, National Organization for Drug Control & Research (NODCAR), Giza, Egypt.
Elfiky AM; Department of Medicinal plants and natural products, National Organization for Drug Control & Research (NODCAR), Giza, Egypt.
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Źródło :
Natural product research [Nat Prod Res] 2021 Jun; Vol. 35 (12), pp. 2103-2106. Date of Electronic Publication: 2019 Aug 22.
Typ publikacji :
Journal Article
MeSH Terms :
Diabetes Mellitus, Experimental/*drug therapy
Hypoglycemic Agents/*chemistry
Hypoglycemic Agents/*pharmacology
Plant Extracts/*pharmacology
Pomegranate/*chemistry
Animals ; Anti-Inflammatory Agents, Non-Steroidal/chemistry ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Antioxidants/analysis ; Antioxidants/chemistry ; Antioxidants/pharmacology ; Chemical Fractionation ; Diabetes Mellitus, Experimental/metabolism ; Dose-Response Relationship, Drug ; Gallic Acid/isolation & purification ; Hypoglycemic Agents/administration & dosage ; Oxidative Stress/drug effects ; Plant Extracts/administration & dosage ; Plant Extracts/chemistry ; Rats ; Rutin/isolation & purification ; Toxicity Tests, Acute
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Structural insights on ligand recognition at the human leukotriene B4 receptor 1.
Autorzy :
Michaelian N; Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA, USA.; Department of Chemistry, University of Southern California, Los Angeles, CA, USA.
Sadybekov A; Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA, USA.; Department of Chemistry, University of Southern California, Los Angeles, CA, USA.
Besserer-Offroy É; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada.; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
Han GW; Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA, USA.; Department of Chemistry, University of Southern California, Los Angeles, CA, USA.
Krishnamurthy H; Merck Research Laboratories, Merck & Co., Inc., Kenilworth, NJ, USA.
Zamlynny BA; Merck Research Laboratories, Merck & Co., Inc., Kenilworth, NJ, USA.
Fradera X; Merck Research Laboratories, Merck & Co., Inc., Kenilworth, NJ, USA.
Siliphaivanh P; Merck Research Laboratories, Merck & Co., Inc., Kenilworth, NJ, USA.
Presland J; Merck Research Laboratories, Merck & Co., Inc., Kenilworth, NJ, USA.
Spencer KB; Merck Research Laboratories, Merck & Co., Inc., Kenilworth, NJ, USA.
Soisson SM; Merck Research Laboratories, Merck & Co., Inc., Kenilworth, NJ, USA.
Popov P; Center for Computational and Data Intensive Science and Engineering, Skolkovo Institute of Science and Technology, Moscow, Russia.; Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, Russia.
Sarret P; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada.
Katritch V; Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA, USA.; Department of Chemistry, University of Southern California, Los Angeles, CA, USA.; Department of Quantitative and Computational Biology, University of Southern California, Los Angeles, CA, USA.
Cherezov V; Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA, USA. .; Department of Chemistry, University of Southern California, Los Angeles, CA, USA. .; Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, Russia. .
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Źródło :
Nature communications [Nat Commun] 2021 May 20; Vol. 12 (1), pp. 2971. Date of Electronic Publication: 2021 May 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Hypoglycemic Agents/*chemistry
Receptors, Leukotriene B4/*ultrastructure
Animals ; Binding Sites/genetics ; Crystallography, X-Ray ; Diabetes Mellitus, Type 2 ; HEK293 Cells ; Humans ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use ; Ligands ; Molecular Docking Simulation ; Mutagenesis, Site-Directed ; Receptors, Leukotriene B4/agonists ; Receptors, Leukotriene B4/antagonists & inhibitors ; Receptors, Leukotriene B4/genetics ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Recombinant Proteins/ultrastructure ; Sf9 Cells ; Spodoptera ; Structure-Activity Relationship
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Positional Isomeric Effects on the Optical Properties, Multivalent Glycosidase Inhibition Effect, and Hypoglycemic Effect of Perylene Bisimide-deoxynojirimycin Conjugates.
Autorzy :
Li RF; College of Chemistry and Environmental Science, Hebei University, Baoding 071002, P. R. China.; Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Ministry of Education), Key Laboratory of Chemical Biology of Hebei Province, Baoding 071002, P. R. China.; Department of Immunology, School of Basic Medical Science, Hebei University, Baoding 071002, P. R. China.
Yang JX; College of Chemistry and Environmental Science, Hebei University, Baoding 071002, P. R. China.; Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Ministry of Education), Key Laboratory of Chemical Biology of Hebei Province, Baoding 071002, P. R. China.
Liu J; College of Veterinary Medicine, Hebei Agricultural University, Baoding 071000, P. R. China.
Ai GM; Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, P. R. China.
Zhang HY; College of Chemistry and Environmental Science, Hebei University, Baoding 071002, P. R. China.; Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Ministry of Education), Key Laboratory of Chemical Biology of Hebei Province, Baoding 071002, P. R. China.
Xu LY; College of Chemistry and Environmental Science, Hebei University, Baoding 071002, P. R. China.
Chen SB; College of Chemistry and Environmental Science, Hebei University, Baoding 071002, P. R. China.
Zhang HX; Medical Comprehensive Experimental Center, Hebei University, Baoding 071002, P. R. China.
Li XL; College of Chemistry and Environmental Science, Hebei University, Baoding 071002, P. R. China.; Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Ministry of Education), Key Laboratory of Chemical Biology of Hebei Province, Baoding 071002, P. R. China.
Cao ZR; Department of Immunology, School of Basic Medical Science, Hebei University, Baoding 071002, P. R. China.
Wang KR; College of Chemistry and Environmental Science, Hebei University, Baoding 071002, P. R. China.; Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Ministry of Education), Key Laboratory of Chemical Biology of Hebei Province, Baoding 071002, P. R. China.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 May 13; Vol. 64 (9), pp. 5863-5873. Date of Electronic Publication: 2021 Apr 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Glucosamine/*analogs & derivatives
Glycoside Hydrolases/*metabolism
Hypoglycemic Agents/*chemistry
Imides/*chemistry
Perylene/*analogs & derivatives
Administration, Oral ; Animals ; Binding Sites ; Blood Glucose/analysis ; Glucosamine/chemistry ; Glycoside Hydrolases/antagonists & inhibitors ; Hydrogen Bonding ; Hypoglycemic Agents/administration & dosage ; Hypoglycemic Agents/metabolism ; Isomerism ; Kinetics ; Mice ; Molecular Conformation ; Molecular Docking Simulation ; Perylene/chemistry ; Protein Binding ; Thermodynamics
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
GPR120/FFAR4 Pharmacology: Focus on Agonists in Type 2 Diabetes Mellitus Drug Discovery.
Autorzy :
Carullo G; Department of Biotechnology, Chemistry, and Pharmacy, DoE 2018-2022, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.
Mazzotta S; Department of Pharmaceutical Sciences, University of Milan, Via Luigi Mangiagalli 25, 20133 Milano, Italy.
Vega-Holm M; Department of Organic and Medicinal Chemistry, Faculty of Pharmacy, University of Seville, Profesor García González 2, 41012 Seville, Spain.
Iglesias-Guerra F; Department of Organic and Medicinal Chemistry, Faculty of Pharmacy, University of Seville, Profesor García González 2, 41012 Seville, Spain.
Vega-Pérez JM; Department of Organic and Medicinal Chemistry, Faculty of Pharmacy, University of Seville, Profesor García González 2, 41012 Seville, Spain.
Aiello F; Department of Pharmacy, Health and Nutritional Sciences, DoE 2018-2022, University of Calabria, Edificio Polifunzionale, 87036 Rende, Cosenza, Italy.
Brizzi A; Department of Biotechnology, Chemistry, and Pharmacy, DoE 2018-2022, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Apr 22; Vol. 64 (8), pp. 4312-4332. Date of Electronic Publication: 2021 Apr 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Discovery*
Hypoglycemic Agents/*chemistry
Phenylpropionates/*chemistry
Receptors, G-Protein-Coupled/*agonists
Adipogenesis ; Animals ; Carboxylic Acids/chemistry ; Carboxylic Acids/metabolism ; Carboxylic Acids/therapeutic use ; Diabetes Mellitus, Type 2/drug therapy ; Humans ; Hypoglycemic Agents/metabolism ; Hypoglycemic Agents/therapeutic use ; Ligands ; Mice ; Phenylpropionates/metabolism ; Phenylpropionates/therapeutic use ; Receptors, G-Protein-Coupled/metabolism ; Structure-Activity Relationship ; Sulfonamides/chemistry ; Sulfonamides/metabolism ; Sulfonamides/therapeutic use
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Exendin 4-Hapten Conjugate Capable of Binding with Endogenous Antibodies for Peptide Half-life Extension and Exerting Long-Acting Hypoglycemic Activity.
Autorzy :
Dai S; Key Laboratory of Carbohydrate Chemistry & Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, 214122 Wuxi, China.
Hong H; Key Laboratory of Carbohydrate Chemistry & Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, 214122 Wuxi, China.
Zhou K; Key Laboratory of Carbohydrate Chemistry & Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, 214122 Wuxi, China.
Zhao K; Key Laboratory of Carbohydrate Chemistry & Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, 214122 Wuxi, China.
Xie Y; Key Laboratory of Carbohydrate Chemistry & Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, 214122 Wuxi, China.
Li C; Key Laboratory of Carbohydrate Chemistry & Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, 214122 Wuxi, China.
Shi J; Key Laboratory of Carbohydrate Chemistry & Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, 214122 Wuxi, China.
Zhou Z; Key Laboratory of Carbohydrate Chemistry & Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, 214122 Wuxi, China.
Nie L; Hisun Biopharmaceutical Co., Limited, 8 Hisun Road, Xialian Village, Xukou Town, Fuyang District, 311404 Hangzhou, Zhejiang, China.
Wu Z; Key Laboratory of Carbohydrate Chemistry & Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, 214122 Wuxi, China.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Apr 22; Vol. 64 (8), pp. 4947-4959. Date of Electronic Publication: 2021 Apr 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies/*blood
Exenatide/*chemistry
Haptens/*chemistry
Hypoglycemic Agents/*chemical synthesis
Amino Acid Sequence ; Animals ; Antibodies/immunology ; Antigen-Antibody Complex/chemistry ; Antigen-Antibody Complex/metabolism ; Blood Glucose/analysis ; Diabetes Mellitus, Experimental/drug therapy ; Dinitrobenzenes/chemistry ; Dinitrobenzenes/immunology ; Drug Design ; Female ; Glucagon-Like Peptide-1 Receptor/agonists ; Glucagon-Like Peptide-1 Receptor/metabolism ; Glucose Tolerance Test ; Half-Life ; Haptens/immunology ; Hypoglycemic Agents/metabolism ; Hypoglycemic Agents/therapeutic use ; Liver/drug effects ; Liver/metabolism ; Liver/pathology ; Mice ; Mice, Inbred C57BL
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Concise perspectives on some synthetic thiazolidine-2,4-dione derivatives and their specific pharmacodynamic aspects.
Autorzy :
Vulichi SR; Sri Venkateswara University College of Pharmaceutical Sciences, S V University, Tirupati, Andhra Pradesh, India; Department of Biological Sciences, BITS, Pilani, Hyderabad Campus, Telangana, India.
Kabra A; School of Pharmacy, Raffles University, Neemrana, Alwar, Rajasthan, India.
Kumar R; CDSCO, FDA Bhawan, New Delhi, India.
Suman K; Department of Biological Sciences, BITS, Pilani, Hyderabad Campus, Telangana, India. Electronic address: .
Rao CV; Department of Chemistry, Sri Venkateswara University, Tirupati, Andhra Pradesh, India.
Cruz-Martins N; Faculty of Medicine, University of Porto, Alameda Prof. Hernani Monteiro, 4200-319 Porto, Portugal; Institute for research and Innovation in Heath (i3S), University of Porto, Rua Alfredo Allen, 4200-135 Porto, Portugal; Laboratory of Neuropsychophysiology, Faculty of Psychology and Education Sciences, University of Porto, Portugal. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Apr 15; Vol. 271, pp. 119182. Date of Electronic Publication: 2021 Feb 09.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Hypoglycemic Agents/*chemistry
Hypoglycemic Agents/*metabolism
Thiazolidinediones/*chemistry
Thiazolidinediones/*metabolism
Animals ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/metabolism ; Glucose/antagonists & inhibitors ; Glucose/metabolism ; Humans ; Hypoglycemic Agents/therapeutic use ; Insulin Resistance/physiology ; PPAR gamma/metabolism ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Thiazolidinediones/therapeutic use
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Structure-Activity Relationship Study and Biological Evaluation of 2-(Disubstituted phenyl)-indole-5-propanoic Acid Derivatives as GPR40 Full Agonists.
Autorzy :
Zhao X; School of Pharmacy, Sungkyunkwan University, Suwon 16419, South Korea.
Yoon DO; School of Pharmacy, Sungkyunkwan University, Suwon 16419, South Korea.
Yoo J; School of Pharmacy, Sungkyunkwan University, Suwon 16419, South Korea.
Park HJ; School of Pharmacy, Sungkyunkwan University, Suwon 16419, South Korea.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Apr 08; Vol. 64 (7), pp. 4130-4149. Date of Electronic Publication: 2021 Mar 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Diabetes Mellitus, Type 2/*drug therapy
Hypoglycemic Agents/*therapeutic use
Indoles/*therapeutic use
Propionates/*therapeutic use
Receptors, G-Protein-Coupled/*agonists
Animals ; Glucagon-Like Peptide 1/metabolism ; Hypoglycemic Agents/chemical synthesis ; Hypoglycemic Agents/metabolism ; Hypoglycemic Agents/pharmacokinetics ; Indoles/chemical synthesis ; Indoles/metabolism ; Indoles/pharmacokinetics ; Insulin/metabolism ; Insulin Secretion/drug effects ; Male ; Mice, Inbred C57BL ; Molecular Docking Simulation ; Molecular Structure ; Propionates/chemical synthesis ; Propionates/metabolism ; Propionates/pharmacokinetics ; Protein Binding ; Receptors, G-Protein-Coupled/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Whole Alga, Algal Extracts, and Compounds as Ingredients of Functional Foods: Composition and Action Mechanism Relationships in the Prevention and Treatment of Type-2 Diabetes Mellitus.
Autorzy :
Bocanegra A; Pharmacology, Pharmacognosy and Botany Department, Pharmacy School, Complutense University of Madrid, 28040 Madrid, Spain.
Macho-González A; Nutrition and Food Science Department (Nutrition), Pharmacy School, Complutense University of Madrid, 28040 Madrid, Spain.; AFUSAN Group, Sanitary Research Institute of the San Carlos Clinical Hospital (IdISSC), 28040 Madrid, Spain.
Garcimartín A; Pharmacology, Pharmacognosy and Botany Department, Pharmacy School, Complutense University of Madrid, 28040 Madrid, Spain.; AFUSAN Group, Sanitary Research Institute of the San Carlos Clinical Hospital (IdISSC), 28040 Madrid, Spain.
Benedí J; Pharmacology, Pharmacognosy and Botany Department, Pharmacy School, Complutense University of Madrid, 28040 Madrid, Spain.; AFUSAN Group, Sanitary Research Institute of the San Carlos Clinical Hospital (IdISSC), 28040 Madrid, Spain.
Sánchez-Muniz FJ; Nutrition and Food Science Department (Nutrition), Pharmacy School, Complutense University of Madrid, 28040 Madrid, Spain.; AFUSAN Group, Sanitary Research Institute of the San Carlos Clinical Hospital (IdISSC), 28040 Madrid, Spain.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Apr 07; Vol. 22 (8). Date of Electronic Publication: 2021 Apr 07.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Biological Products/*chemistry
Biological Products/*pharmacology
Food Ingredients/*analysis
Functional Food/*analysis
Hypoglycemic Agents/*chemistry
Hypoglycemic Agents/*pharmacology
Microalgae/*chemistry
Animals ; Antioxidants/chemistry ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Biological Products/therapeutic use ; Biomarkers ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/etiology ; Diabetes Mellitus, Type 2/metabolism ; Disease Management ; Disease Susceptibility ; Dysbiosis ; Energy Metabolism/drug effects ; Genetic Predisposition to Disease ; Humans ; Hypoglycemic Agents/therapeutic use ; Microalgae/classification ; Microbiota
Czasopismo naukowe
Szczegóły Pełny tekst Pełny tekst
Podgląd okładki
Tytuł :
In vitro and in vivo antidiabetic activity of Tamarix stricta Boiss.: Role of autophagy.
Autorzy :
Bahramsoltani R; Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran; PhytoPharmacology Interest Group (PPIG), Universal Scientific Education and Research Network (USERN), Tehran, Iran. Electronic address: .
Farzaei MH; Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran; Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address: .
Sajadimajd S; Department of Biology, Faculty of Science, Razi University, Kermanshah, Iran. Electronic address: .
Iranpanah A; Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran; Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address: .
Khazaei M; Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address: .
Pourjabar Z; Drug and Food Control Department, Faculty of Pharmacy, and Food and Drug Administration, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: .
Hajimahmoodi M; Drug and Food Control Department, Faculty of Pharmacy, and Food and Drug Administration, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: .
Rahimi R; Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran; PhytoPharmacology Interest Group (PPIG), Universal Scientific Education and Research Network (USERN), Tehran, Iran. Electronic address: .
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Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2021 Apr 06; Vol. 269, pp. 113692. Date of Electronic Publication: 2020 Dec 13.
Typ publikacji :
Journal Article
MeSH Terms :
Tamaricaceae*
Autophagy/*drug effects
Diabetes Mellitus, Experimental/*drug therapy
Hypoglycemic Agents/*therapeutic use
Plant Extracts/*therapeutic use
Animals ; Autophagy/physiology ; Diabetes Mellitus, Experimental/etiology ; Diabetes Mellitus, Experimental/metabolism ; Diet, High-Fat/adverse effects ; Dose-Response Relationship, Drug ; Hypoglycemic Agents/isolation & purification ; Hypoglycemic Agents/pharmacology ; Insulin-Secreting Cells/drug effects ; Insulin-Secreting Cells/metabolism ; Male ; Mice ; Plant Extracts/isolation & purification ; Plant Extracts/pharmacology ; Rats ; Streptozocin
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Protease Inhibitors Purified from the Canola Meal Extracts of Two Genetically Diverse Genotypes Exhibit Antidiabetic and Antihypertension Properties.
Autorzy :
Hussain S; Graham Centre (an Alliance between Charles Sturt University and the NSW Department of Primary Industries), Boorooma Street, Wagga Wagga, NSW 2678, Australia.; ARC Industrial Transformation Training Centre for Functional Grains, School of Biomedical Sciences, Charles Sturt University, Boorooma Street, Wagga Wagga, NSW 2678, Australia.
Rehman AU; Graham Centre (an Alliance between Charles Sturt University and the NSW Department of Primary Industries), Boorooma Street, Wagga Wagga, NSW 2678, Australia.; ARC Industrial Transformation Training Centre for Functional Grains, School of Biomedical Sciences, Charles Sturt University, Boorooma Street, Wagga Wagga, NSW 2678, Australia.
Luckett DJ; Graham Centre (an Alliance between Charles Sturt University and the NSW Department of Primary Industries), Boorooma Street, Wagga Wagga, NSW 2678, Australia.
Naqvi SMS; Graham Centre (an Alliance between Charles Sturt University and the NSW Department of Primary Industries), Boorooma Street, Wagga Wagga, NSW 2678, Australia.
Blanchard CL; Graham Centre (an Alliance between Charles Sturt University and the NSW Department of Primary Industries), Boorooma Street, Wagga Wagga, NSW 2678, Australia.; ARC Industrial Transformation Training Centre for Functional Grains, School of Biomedical Sciences, Charles Sturt University, Boorooma Street, Wagga Wagga, NSW 2678, Australia.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Apr 04; Vol. 26 (7). Date of Electronic Publication: 2021 Apr 04.
Typ publikacji :
Journal Article
MeSH Terms :
Antihypertensive Agents/*pharmacology
Brassica napus/*chemistry
Dipeptidyl Peptidase 4/*chemistry
Enzyme Inhibitors/*pharmacology
Hypoglycemic Agents/*pharmacology
Peptidyl-Dipeptidase A/*chemistry
Amino Acid Sequence ; Antihypertensive Agents/chemistry ; Antihypertensive Agents/isolation & purification ; Brassica napus/genetics ; Brassica napus/metabolism ; Dipeptidyl Peptidase 4/metabolism ; Enzyme Assays ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/isolation & purification ; Genotype ; Humans ; Hypoglycemic Agents/chemistry ; Hypoglycemic Agents/isolation & purification ; Isoelectric Focusing ; Kinetics ; Liquid-Liquid Extraction/methods ; Peptidyl-Dipeptidase A/metabolism ; Plant Extracts/chemistry
Czasopismo naukowe
Szczegóły Pełny tekst
Podgląd okładki
Tytuł :
Targeting the Protective Arm of the Renin-Angiotensin System: Focused on Angiotensin-(1-7).
Autorzy :
Khajehpour S; Department of Biomedical and Pharmaceutical Sciences, Idaho State University, Pocatello, ID.
Aghazadeh-Habashi A; Department of Biomedical and Pharmaceutical Sciences, Idaho State University, Pocatello, ID .
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Źródło :
The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2021 Apr; Vol. 377 (1), pp. 64-74. Date of Electronic Publication: 2021 Jan 25.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Angiotensin I/*pharmacology
Antihypertensive Agents/*pharmacology
Hypoglycemic Agents/*pharmacology
Peptide Fragments/*pharmacology
Renin-Angiotensin System/*drug effects
Angiotensin I/administration & dosage ; Angiotensin I/therapeutic use ; Animals ; Antihypertensive Agents/administration & dosage ; Antihypertensive Agents/therapeutic use ; Drug Delivery Systems ; Humans ; Hypoglycemic Agents/administration & dosage ; Hypoglycemic Agents/therapeutic use ; Peptide Fragments/administration & dosage ; Peptide Fragments/therapeutic use
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
The cost-effectiveness of once-weekly semaglutide compared with other GLP-1 receptor agonists in type 2 Diabetes: a systematic literature review.
Autorzy :
Ruan Z; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao SAR, China.
Yang L; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao SAR, China.
Shi H; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao SAR, China.
Yue X; Pharmacy Practice & Administrative Sciences, James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio, USA.
Wang Y; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao SAR, China.
Liang M; International Health Management, Imperial College Business School, Imperial College London, London, UK.
Hu H; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao SAR, China.
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Źródło :
Expert review of pharmacoeconomics & outcomes research [Expert Rev Pharmacoecon Outcomes Res] 2021 Apr; Vol. 21 (2), pp. 221-233. Date of Electronic Publication: 2021 Jan 12.
Typ publikacji :
Comparative Study; Journal Article; Systematic Review
MeSH Terms :
Diabetes Mellitus, Type 2/*drug therapy
Glucagon-Like Peptides/*administration & dosage
Hypoglycemic Agents/*administration & dosage
Cost-Benefit Analysis ; Diabetes Mellitus, Type 2/economics ; Drug Administration Schedule ; Economics, Pharmaceutical ; Glucagon-Like Peptide-1 Receptor/agonists ; Glucagon-Like Peptides/economics ; Glucagon-Like Peptides/pharmacology ; Humans ; Hypoglycemic Agents/economics ; Hypoglycemic Agents/pharmacology
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Excessive Basal Insulin Dosage When Following the Accepted Titration Method.
Autorzy :
King AB; Diabetes Care Center, 1260 South Main, Suite 202, Salinas, California 93901. Electronic address: .
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Źródło :
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists [Endocr Pract] 2021 Jun; Vol. 27 (6), pp. 642. Date of Electronic Publication: 2021 Mar 08.
Typ publikacji :
Letter
MeSH Terms :
Diabetes Mellitus, Type 2*/drug therapy
Hypoglycemic Agents*/adverse effects
Blood Glucose ; Humans ; Insulin ; Insulin Glargine
Opinia redakcyjna
Szczegóły
Podgląd okładki
Tytuł :
Metformin use and risk of COVID-19 among patients with type II diabetes mellitus: an NHIS-COVID-19 database cohort study.
Autorzy :
Oh TK; Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Gumi-ro 173 Beon-gil, Bundang-gu, Seongnam, 13620, Korea.
Song IA; Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Gumi-ro 173 Beon-gil, Bundang-gu, Seongnam, 13620, Korea. .
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Źródło :
Acta diabetologica [Acta Diabetol] 2021 Jun; Vol. 58 (6), pp. 771-778. Date of Electronic Publication: 2021 Feb 13.
Typ publikacji :
Journal Article
MeSH Terms :
COVID-19/*epidemiology
Databases, Factual/*trends
Diabetes Mellitus, Type 2/*epidemiology
Hypoglycemic Agents/*therapeutic use
Metformin/*therapeutic use
National Health Programs/*trends
Adult ; Aged ; COVID-19/chemically induced ; COVID-19/prevention & control ; Cohort Studies ; Diabetes Mellitus, Type 2/drug therapy ; Hospital Mortality/trends ; Humans ; Hypoglycemic Agents/adverse effects ; Male ; Metformin/adverse effects ; Middle Aged ; Republic of Korea/epidemiology ; Risk Factors
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
A Virtual Training Program for the Tandem t:slim X2 Insulin Pump: Implementation and Outcomes.
Autorzy :
Pinsker JE; Sansum Diabetes Research Institute, Santa Barbara, California, USA.
Singh H; Tandem Diabetes Care, Behavioral Sciences, San Diego, California, USA.
McElwee Malloy M; Tandem Diabetes Care, Behavioral Sciences, San Diego, California, USA.
Constantin A; Tandem Diabetes Care, Data Science, San Diego, California, USA.
Leas S; Tandem Diabetes Care, Data Science, San Diego, California, USA.
Kriegel K; Tandem Diabetes Care, Clinical Services, San Diego, California, USA.
Habif S; Tandem Diabetes Care, Behavioral Sciences, San Diego, California, USA.
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Źródło :
Diabetes technology & therapeutics [Diabetes Technol Ther] 2021 Jun; Vol. 23 (6), pp. 467-470. Date of Electronic Publication: 2021 Feb 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Insulin Infusion Systems*
Diabetes Mellitus/*drug therapy
Hypoglycemia/*epidemiology
Hypoglycemic Agents/*administration & dosage
Insulin/*administration & dosage
Patient Education as Topic/*methods
Telemedicine/*methods
Adolescent ; Adult ; Age Factors ; Aged ; COVID-19 ; Child ; Curriculum ; Diabetes Mellitus/metabolism ; Educational Measurement ; Feasibility Studies ; Female ; Glycated Hemoglobin A/metabolism ; Humans ; Hypoglycemic Agents/therapeutic use ; Infusion Pumps, Implantable ; Insulin/therapeutic use ; Male ; Middle Aged ; SARS-CoV-2 ; Young Adult
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Surrogate endpoint evaluation using data from one large global randomized controlled trial.
Autorzy :
Geybels M; Novo Nordisk A/S, Vandtårnsvej 110-114, 2860, Søborg, Denmark.
Wolthers BO; Novo Nordisk A/S, Vandtårnsvej 110-114, 2860, Søborg, Denmark.
Kreiner FF; Novo Nordisk A/S, Vandtårnsvej 110-114, 2860, Søborg, Denmark. .
Rasmussen S; Novo Nordisk A/S, Vandtårnsvej 110-114, 2860, Søborg, Denmark.
Bauer R; Novo Nordisk A/S, Vandtårnsvej 110-114, 2860, Søborg, Denmark.
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Źródło :
BMC medical informatics and decision making [BMC Med Inform Decis Mak] 2021 May 20; Vol. 21 (1), pp. 164. Date of Electronic Publication: 2021 May 20.
Typ publikacji :
Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't
MeSH Terms :
Biometry*
Hypoglycemic Agents*
Biomarkers ; Humans ; Proportional Hazards Models ; Randomized Controlled Trials as Topic
Czasopismo naukowe
Szczegóły Pełny tekst
Podgląd okładki
Tytuł :
Novel FoxO1 inhibitor, JY-2, ameliorates palmitic acid-induced lipotoxicity and gluconeogenesis in a murine model.
Autorzy :
Choi HE; Department of Pharmacology, College of Medicine, Gachon University, Incheon, 21999, South Korea.
Kim Y; Severance Institute for Vascular and Metabolic Research Yonsei University School of Medicine, Seoul, 06230, South Korea.
Lee HJ; College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, 21983, South Korea.
Cheon HG; Department of Pharmacology, College of Medicine, Gachon University, Incheon, 21999, South Korea; Department of Health Sciences and Technology, GAIHST, Gachon University, Incheon, 21999, Republic of Korea. Electronic address: .
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 2021 May 15; Vol. 899, pp. 174011. Date of Electronic Publication: 2021 Mar 09.
Typ publikacji :
Journal Article
MeSH Terms :
Diabetes Mellitus/*drug therapy
Gluconeogenesis/*drug effects
Hepatocytes/*drug effects
Hypoglycemic Agents/*pharmacology
Lipid Metabolism/*drug effects
Nerve Tissue Proteins/*antagonists & inhibitors
Oxadiazoles/*pharmacology
Animals ; Blood Glucose/drug effects ; Blood Glucose/metabolism ; Diabetes Mellitus/enzymology ; Diabetes Mellitus/pathology ; Diet, High-Fat ; Disease Models, Animal ; Gene Expression Regulation, Enzymologic ; Hep G2 Cells ; Hepatocytes/enzymology ; Hepatocytes/pathology ; Humans ; Hypoglycemic Agents/pharmacokinetics ; Male ; Mice, Inbred C57BL ; Nerve Tissue Proteins/metabolism ; Obesity/complications ; Oxadiazoles/pharmacokinetics ; Palmitic Acid/toxicity ; Rats ; Signal Transduction
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Metformin turns 62 in pharmacotherapy: Emergence of non-glycaemic effects and potential novel therapeutic applications.
Autorzy :
Mbara KC; Molecular and Clinical Pharmacology Research Laboratory, Department of Pharmacology, Discipline of Pharmaceutical Sciences, University of Kwazulu-Natal, P.O. Box X5401, Durban, South Africa.
Mofo Mato PE; Molecular and Clinical Pharmacology Research Laboratory, Department of Pharmacology, Discipline of Pharmaceutical Sciences, University of Kwazulu-Natal, P.O. Box X5401, Durban, South Africa.
Driver C; Molecular and Clinical Pharmacology Research Laboratory, Department of Pharmacology, Discipline of Pharmaceutical Sciences, University of Kwazulu-Natal, P.O. Box X5401, Durban, South Africa.
Nzuza S; Molecular and Clinical Pharmacology Research Laboratory, Department of Pharmacology, Discipline of Pharmaceutical Sciences, University of Kwazulu-Natal, P.O. Box X5401, Durban, South Africa.
Mkhombo NT; Molecular and Clinical Pharmacology Research Laboratory, Department of Pharmacology, Discipline of Pharmaceutical Sciences, University of Kwazulu-Natal, P.O. Box X5401, Durban, South Africa.
Gcwensa SK; Molecular and Clinical Pharmacology Research Laboratory, Department of Pharmacology, Discipline of Pharmaceutical Sciences, University of Kwazulu-Natal, P.O. Box X5401, Durban, South Africa.
Mcobothi EN; Molecular and Clinical Pharmacology Research Laboratory, Department of Pharmacology, Discipline of Pharmaceutical Sciences, University of Kwazulu-Natal, P.O. Box X5401, Durban, South Africa.
Owira PM; Molecular and Clinical Pharmacology Research Laboratory, Department of Pharmacology, Discipline of Pharmaceutical Sciences, University of Kwazulu-Natal, P.O. Box X5401, Durban, South Africa. Electronic address: .
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 2021 May 05; Vol. 898, pp. 173934. Date of Electronic Publication: 2021 Feb 17.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Anti-Infective Agents/*therapeutic use
Antineoplastic Agents/*therapeutic use
Hypoglycemic Agents/*therapeutic use
Immunologic Factors/*therapeutic use
Metformin/*therapeutic use
Protective Agents/*therapeutic use
Animals ; Anti-Infective Agents/adverse effects ; Antineoplastic Agents/adverse effects ; COVID-19/drug therapy ; COVID-19/epidemiology ; Cardiovascular Diseases/prevention & control ; Female ; Humans ; Hypoglycemic Agents/adverse effects ; Immunologic Factors/adverse effects ; Kidney Diseases/prevention & control ; Metabolic Syndrome/drug therapy ; Metformin/adverse effects ; Obesity/drug therapy ; Pandemics ; Polycystic Ovary Syndrome/drug therapy ; Protective Agents/adverse effects ; SARS-CoV-2
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Semaglutide for obesity: four STEPs forward, but more to come.
Autorzy :
Ryan DH; Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA. Electronic address: .
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Źródło :
The lancet. Diabetes & endocrinology [Lancet Diabetes Endocrinol] 2021 May; Vol. 9 (5), pp. 252-254.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Glucagon-Like Peptide-1 Receptor/*agonists
Glucagon-Like Peptides/*therapeutic use
Hypoglycemic Agents/*therapeutic use
Obesity/*drug therapy
Animals ; Clinical Trials, Phase III as Topic/methods ; Energy Metabolism/drug effects ; Energy Metabolism/physiology ; Glucagon-Like Peptide-1 Receptor/metabolism ; Glucagon-Like Peptides/pharmacology ; Humans ; Hypoglycemic Agents/pharmacology ; Obesity/metabolism
Czasopismo naukowe
Szczegóły
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