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Tytuł:
Synthesis and potential antidiabetic and lipid-lowering activities of putative asperidine B and its desmethyl analogue.
Autorzy:
Thongpat K; Division of Physical Science and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand.
Holasut P; Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Ontawong A; Division of Physiology, School of Medical Sciences, University of Phayao, Phayao 56000, Thailand.
Inchai J; Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Duangjai A; Division of Physiology, School of Medical Sciences, University of Phayao, Phayao 56000, Thailand.
Rukachaisirikul V; Division of Physical Science and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand.
Vaddhanaphuti CS; Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Tadpetch K; Division of Physical Science and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand. Electronic address: .
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Źródło:
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2023 Sep 01; Vol. 93, pp. 129437. Date of Electronic Publication: 2023 Aug 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Hypoglycemic Agents*/pharmacology
Hypoglycemic Agents*/chemistry
Antioxidants*/chemistry
Humans ; Caco-2 Cells ; Plant Extracts/chemistry ; Superoxide Dismutase/metabolism ; Lipids
Czasopismo naukowe
Szczegóły
Tytuł:
Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target.
Autorzy:
Wang K; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Peking University, Beijing, China.; Center for Obesity and Metabolic Disease Research, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, China.
Zhang Z; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Peking University, Beijing, China.; Center for Obesity and Metabolic Disease Research, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, China.
Hang J; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Peking University, Beijing, China.; Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.; National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital), Beijing, China.
Liu J; Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Guo F; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Synthetic and Functional Biomolecules Center, Peking University, Beijing, China.; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China.
Ding Y; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Peking University, Beijing, China.; Center for Obesity and Metabolic Disease Research, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, China.
Li M; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Peking University, Beijing, China.; Center for Obesity and Metabolic Disease Research, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, China.
Nie Q; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Peking University, Beijing, China.; Center for Obesity and Metabolic Disease Research, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, China.
Lin J; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Peking University, Beijing, China.; Center for Obesity and Metabolic Disease Research, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, China.
Zhuo Y; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Peking University, Beijing, China.; Center for Obesity and Metabolic Disease Research, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, China.
Sun L; Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Luo X; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Peking University, Beijing, China.; Center for Obesity and Metabolic Disease Research, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, China.
Zhong Q; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Peking University, Beijing, China.; Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.; National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital), Beijing, China.
Ye C; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Peking University, Beijing, China.; Center for Obesity and Metabolic Disease Research, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, China.
Yun C; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Peking University, Beijing, China.; Center for Obesity and Metabolic Disease Research, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, China.
Zhang Y; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Peking University, Beijing, China.; Center for Obesity and Metabolic Disease Research, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, China.
Wang J; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Synthetic and Functional Biomolecules Center, Peking University, Beijing, China.
Bao R; Center of Infectious Diseases, Division of Infectious Diseases in State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Pang Y; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Peking University, Beijing, China.; Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.; National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital), Beijing, China.
Wang G; Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Gonzalez FJ; Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Lei X; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Synthetic and Functional Biomolecules Center, Peking University, Beijing, China.; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China.
Qiao J; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Peking University, Beijing, China.; Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.; National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital), Beijing, China.; Beijing Advanced Innovation Center for Genomics, Beijing, China.
Jiang C; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Peking University, Beijing, China.; Center for Obesity and Metabolic Disease Research, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, China.; Center of Basic Medical Research, Institute of Medical Innovation and Research, Third Hospital, Peking University, Beijing, China.
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Źródło:
Science (New York, N.Y.) [Science] 2023 Aug 04; Vol. 381 (6657), pp. eadd5787. Date of Electronic Publication: 2023 Aug 04.
Typ publikacji:
Journal Article
MeSH Terms:
Bacteroides*/drug effects
Bacteroides*/enzymology
Bacteroides*/genetics
Diabetes Mellitus, Type 2*/enzymology
Diabetes Mellitus, Type 2*/microbiology
Dipeptidyl Peptidase 4*/metabolism
Dipeptidyl-Peptidase IV Inhibitors*/pharmacology
Dipeptidyl-Peptidase IV Inhibitors*/therapeutic use
Gastrointestinal Microbiome*
Host Microbial Interactions*
Hypoglycemic Agents*/pharmacology
Hypoglycemic Agents*/therapeutic use
Animals ; Humans ; Mice ; Feces/microbiology ; Glucagon-Like Peptide 1/metabolism ; Glucose/metabolism ; Isoenzymes/metabolism ; Sitagliptin Phosphate/pharmacology ; Sitagliptin Phosphate/therapeutic use
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Safety/tolerability, efficacy and pharmacokinetics of 600-μg cotadutide in Japanese type 2 diabetes patients with a body mass index of 25 kg/m or higher: A phase I, randomized, double-blind, placebo-controlled study.
Autorzy:
Asano M; Medical Science, BioPharmaceuticals TA, R&D, AstraZeneca K.K., Tokyo, Japan.
Sekikawa A; Clinical Science, BioPharmaceuticals TA, R&D, AstraZeneca K.K., Tokyo, Japan.
Sugeno M; Biometrics Department, Science & Data Analytics Division, R&D, AstraZeneca K.K., Osaka, Japan.
Matsuoka O; Medical Corporation Heishinkai ToCROM Clinic, Tokyo, Japan.
Robertson D; Early Clinical Development, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
Hansen L; Early Clinical Development, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, Maryland, USA.
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Źródło:
Diabetes, obesity & metabolism [Diabetes Obes Metab] 2023 Aug; Vol. 25 (8), pp. 2290-2299. Date of Electronic Publication: 2023 Jun 19.
Typ publikacji:
Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:
Diabetes Mellitus, Type 2*/blood
Diabetes Mellitus, Type 2*/drug therapy
Hypoglycemic Agents*/administration & dosage
Hypoglycemic Agents*/adverse effects
Hypoglycemic Agents*/pharmacokinetics
Hypoglycemic Agents*/therapeutic use
Female ; Humans ; Male ; Blood Glucose/analysis ; Blood Glucose Self-Monitoring ; Body Mass Index ; Body Weight ; Double-Blind Method ; East Asian People ; Glycated Hemoglobin ; Treatment Outcome ; Middle Aged ; Injections, Subcutaneous ; Dose-Response Relationship, Drug
Czasopismo naukowe
Szczegóły
Tytuł:
Profiling the Antidiabetic Potential of Compounds Identified from Fractionated Extracts of Entada africana toward Glucokinase Stimulation: Computational Insight.
Autorzy:
Onikanni SA; College of Medicine, Graduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan.; Department of Chemical Sciences, Biochemistry Unit, Afe-Babalola University, Ado-Ekiti 360101, Ekiti State, Nigeria.
Lawal B; Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Munyembaraga V; Institute of Translational Medicine and New Drug Development, College of Medicine, China Medical University, Taichung 40402, Taiwan.; University Teaching Hospital of Butare, Huye 15232, Rwanda.
Bakare OS; Department of Biochemistry, Faculty Science, Adekunle Ajasin University, Akungba Akoko 342111, Ondo State, Nigeria.
Taher M; Department of Pharmaceutical Technology, Kulliyyah of Pharmacy, International Islamic University Malaysia, Kuantan 25200, Pahang, Malaysia.; Pharmaceutics and Translational Research Group, Kulliyyah of Pharmacy, International Islamic University Malaysia, Kuantan 25200, Pahang, Malaysia.
Khotib J; Department of Pharmacy Practice, Faculty of Pharmacy, Airlangga University, Surabaya 60115, Indonesia.
Susanti D; Department of Chemistry, Kulliyyah of Science, International Islamic University Malaysia, Kuantan 25200, Pahang, Malaysia.
Oyinloye BE; Department of Chemical Sciences, Biochemistry Unit, Afe-Babalola University, Ado-Ekiti 360101, Ekiti State, Nigeria.; Biotechnology and Structural Biology (BSB) Group, Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa 3886, South Africa.; Institute of Drug Research and Development, SE Bogoro Center, Afe Babalola University, PMB 5454, Ado-Ekiti 360001, Ekiti State, Nigeria.
Noriega L; College of Medicine, Graduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan.
Famuti A; Honey T Scientific Company, Ibadan 234002, Oyo State, Nigeria.
Fadaka AO; Department of Biotechnology, University of the Western Cape, Bellville 7535, South Africa.
Ajiboye BO; Institute of Drug Research and Development, SE Bogoro Center, Afe Babalola University, PMB 5454, Ado-Ekiti 360001, Ekiti State, Nigeria.; Phytomedicine and Molecular Toxicology Research Laboratory, Department of Biochemistry, Federal University, Oye-Ekiti 371104, Ekiti State, Nigeria.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Jul 30; Vol. 28 (15). Date of Electronic Publication: 2023 Jul 30.
Typ publikacji:
Journal Article
MeSH Terms:
Hypoglycemic Agents*/pharmacology
Hypoglycemic Agents*/therapeutic use
Diabetes Mellitus, Type 2*/drug therapy
Humans ; Molecular Docking Simulation ; Glucokinase/metabolism ; Ligands
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Comparative efficacy and safety of glucagon-like peptide 1 receptor agonists for the treatment of type 2 diabetes: A network meta-analysis.
Autorzy:
Chen H; Department of Pharmacy, General Hospital of Northern Theater Command, Shenyang, People's Republic of China.
Li XZ; Department of Clinical Pharmacy, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
Chen JQ; Department of Clinical Pharmacy, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
Ren TS; Department of Pharmacy, General Hospital of Northern Theater Command, Shenyang, People's Republic of China.; Department of Clinical Pharmacy, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
Zhang YS; Department of Clinical Pharmacy, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
Wang YN; Department of Clinical Pharmacy, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
Zhao QC; Department of Pharmacy, General Hospital of Northern Theater Command, Shenyang, People's Republic of China.; Department of Clinical Pharmacy, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
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Źródło:
Medicine [Medicine (Baltimore)] 2023 Jul 07; Vol. 102 (27), pp. e34122.
Typ publikacji:
Meta-Analysis; Journal Article
MeSH Terms:
Diabetes Mellitus, Type 2*/drug therapy
Glucagon-Like Peptide-1 Receptor*/agonists
Hypoglycemic Agents*/adverse effects
Hypoglycemic Agents*/therapeutic use
Humans ; Glycated Hemoglobin ; Network Meta-Analysis
Czasopismo naukowe
Szczegóły
Tytuł:
Integration of network pharmacology, transcriptomics and molecular docking reveals two novel hypoglycemic components in snow chrysanthemum.
Autorzy:
Lv Q; Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China; Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing 100193, China.
Wu X; Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China; Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing 100193, China.
Guan Y; Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China; Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing 100193, China.
Lin J; Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China; Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing 100193, China.
Sun Y; Xinjiang Key Laboratory for Uighur Medicines, Xinjiang Institute of Materia Medica, Urumqi 830004, China.
Hu M; Xinjiang Key Laboratory for Uighur Medicines, Xinjiang Institute of Materia Medica, Urumqi 830004, China.
Xiao P; Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China; Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing 100193, China.
He C; Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China; Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing 100193, China. Electronic address: .
Jiang B; Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China; Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing 100193, China. Electronic address: .
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Źródło:
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2023 Jul; Vol. 163, pp. 114818. Date of Electronic Publication: 2023 May 12.
Typ publikacji:
Journal Article
MeSH Terms:
Hypoglycemic Agents*/pharmacology
Hypoglycemic Agents*/therapeutic use
Chrysanthemum*/chemistry
Mice ; Animals ; Molecular Docking Simulation ; PPAR gamma/genetics ; PPAR gamma/metabolism ; Network Pharmacology ; Transcriptome ; Mice, Inbred C57BL ; Glucose ; Flavonoids/pharmacology ; Tea
Czasopismo naukowe
Szczegóły
Tytuł:
Insulin edema, a little known entity.
Autorzy:
Herrero MH; Paediatric Endocrinology Department, Joan XXIII University Hospital, Carrer Llunas I Pujals, núm4, 4º2ª, 43202, Reus, Tarragona, Spain. .
Zaragoza NR; Paediatric Endocrinology Department, Verge de La Cinta Hospital, Tortosa, Spain.
Llop ME; Paediatric Endocrinology Department, Verge de La Cinta Hospital, Tortosa, Spain.
Rovira AF; Paediatric Endocrinology Department, Sant Joan de Reus University Hospital, Reus, Spain.
Mercader PT; Paediatric Endocrinology Department, Pius Hospital, Valls, Spain.
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Źródło:
Acta diabetologica [Acta Diabetol] 2023 Jul; Vol. 60 (7), pp. 995-997. Date of Electronic Publication: 2023 Mar 13.
Typ publikacji:
Case Reports; Journal Article
MeSH Terms:
Diabetes Mellitus, Type 1*/drug therapy
Diabetic Ketoacidosis*/drug therapy
Edema*/chemically induced
Edema*/diagnosis
Edema*/drug therapy
Hypoglycemic Agents*/adverse effects
Hypoglycemic Agents*/therapeutic use
Insulin*/adverse effects
Insulin*/therapeutic use
Adolescent ; Female ; Humans
Czasopismo naukowe
Szczegóły
Tytuł:
Combined Experimental and Computational Study of V-Substituted Lindqvist Polyoxotungstate: Screening by Docking for Potential Antidiabetic Activity.
Autorzy:
Maalaoui A; Laboratory of Materials Chemistry, Faculty of Sciences of Bizerte, 7021 Zarzouna, Bizerte, Tunisia.
Agwamba EC; Department of Chemistry, Covenant University, Idiroko Road, P.M.B, Ota 1023, Ogun State, Nigeria.; Computational and Bio-Simulation Research Group, University of Calabar, P.M.B. 1115, Calabar 540221, Nigeria.
Louis H; Computational and Bio-Simulation Research Group, University of Calabar, P.M.B. 1115, Calabar 540221, Nigeria.; Department of Pure and Applied Chemistry, University of Calabar, P.M.B. 1115, Calabar 540221, Nigeria.
Mathias GE; Computational and Bio-Simulation Research Group, University of Calabar, P.M.B. 1115, Calabar 540221, Nigeria.; Department of Pure and Applied Chemistry, University of Calabar, P.M.B. 1115, Calabar 540221, Nigeria.
Rzaigui M; Laboratory of Materials Chemistry, Faculty of Sciences of Bizerte, 7021 Zarzouna, Bizerte, Tunisia.
Akriche S; Laboratory of Materials Chemistry, Faculty of Sciences of Bizerte, 7021 Zarzouna, Bizerte, Tunisia.
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Źródło:
Inorganic chemistry [Inorg Chem] 2023 Sep 04; Vol. 62 (35), pp. 14279-14290. Date of Electronic Publication: 2023 Aug 24.
Typ publikacji:
Journal Article
MeSH Terms:
Hypoglycemic Agents*/chemistry
Drug Evaluation, Preclinical*/methods
Computer Simulation ; Tungsten Compounds/chemistry ; Polymers/chemistry ; Models, Molecular ; Protein Structure, Tertiary
Czasopismo naukowe
Szczegóły
Tytuł:
The Impact of Food Processing on the Structure and Hypoglycemic Effect of Oat β-glucan.
Autorzy:
Zhang Y; College of Food Science & Technology, Shanghai Ocean University, Shanghai, 201306, China.
Li J; College of Food Science & Technology, Shanghai Ocean University, Shanghai, 201306, China.
Xie J; College of Food Science & Technology, Shanghai Ocean University, Shanghai, 201306, China.
Xue B; College of Food Science & Technology, Shanghai Ocean University, Shanghai, 201306, China.
Li X; College of Food Science & Technology, Shanghai Ocean University, Shanghai, 201306, China.
Gan J; College of Food Science & Technology, Shanghai Ocean University, Shanghai, 201306, China.
Sun T; College of Food Science & Technology, Shanghai Ocean University, Shanghai, 201306, China. .
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Źródło:
Plant foods for human nutrition (Dordrecht, Netherlands) [Plant Foods Hum Nutr] 2023 Sep; Vol. 78 (3), pp. 506-511. Date of Electronic Publication: 2023 Aug 25.
Typ publikacji:
Journal Article
MeSH Terms:
Hypoglycemic Agents*/pharmacology
beta-Glucans*/pharmacology
alpha-Glucosidases ; Food Handling ; Starch ; Weight Gain ; alpha-Amylases
Czasopismo naukowe
Szczegóły
Tytuł:
Orforglipron (LY3502970), a novel, oral non-peptide glucagon-like peptide-1 receptor agonist: A Phase 1a, blinded, placebo-controlled, randomized, single- and multiple-ascending-dose study in healthy participants.
Autorzy:
Pratt E; Lilly Centre for Clinical Pharmacology Pte Ltd, Singapore.
Ma X; Eli Lilly and Company, Indianapolis, Indiana, USA.
Liu R; Eli Lilly and Company, Indianapolis, Indiana, USA.
Robins D; Eli Lilly and Company, Indianapolis, Indiana, USA.
Haupt A; Eli Lilly and Company, Indianapolis, Indiana, USA.
Coskun T; Eli Lilly and Company, Indianapolis, Indiana, USA.
Sloop KW; Eli Lilly and Company, Indianapolis, Indiana, USA.
Benson C; Eli Lilly and Company, Indianapolis, Indiana, USA.
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Źródło:
Diabetes, obesity & metabolism [Diabetes Obes Metab] 2023 Sep; Vol. 25 (9), pp. 2634-2641. Date of Electronic Publication: 2023 Jun 21.
Typ publikacji:
Randomized Controlled Trial; Clinical Trial, Phase I; Journal Article
MeSH Terms:
Hypoglycemic Agents*
Diabetes Mellitus, Type 2*/drug therapy
Adult ; Humans ; Glucagon-Like Peptide-1 Receptor/therapeutic use ; Healthy Volunteers ; Blood Glucose ; Double-Blind Method
Czasopismo naukowe
Szczegóły
Tytuł:
Glibenclamide promotes FGF21 secretion in interscapular BAT and attenuates depression-like behaviors in male mice with HFD-induced obesity.
Autorzy:
Kuo YY; Department of Physiology, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, Taiwan; Institue of Basic Medical Sciences, College of Medicine, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, Taiwan.
Tsai HY; Department of Physiology, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, Taiwan.
Kuo YM; Department of Cell Biology and Anatomy, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, Taiwan.
Tzeng SF; Department of Life Sciences, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, Taiwan.
Chen PS; Department of Psychiatry, National Cheng Kung University Hospital, Taiwan.
Hsu PH; Department of Medical Research and Development, Chang Gung Memorial Hospital, Linkou, Taiwan.
Lin YT; Graduate Institute of Metabolism and Obesity Sciences, College of Nutrition, Taipei Medical University, Taiwan.
Chen PC; Department of Physiology, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, Taiwan; Institue of Basic Medical Sciences, College of Medicine, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, Taiwan. Electronic address: .
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Źródło:
Life sciences [Life Sci] 2023 Sep 01; Vol. 328, pp. 121900. Date of Electronic Publication: 2023 Jun 28.
Typ publikacji:
Journal Article
MeSH Terms:
Adipose Tissue, Brown*/drug effects
Depression*/complications
Depression*/drug therapy
Fibroblast Growth Factors*/administration & dosage
Fibroblast Growth Factors*/genetics
Glyburide*/administration & dosage
Hypoglycemic Agents*/administration & dosage
Obesity*/complications
Obesity*/drug therapy
Obesity*/pathology
Animals ; Male ; Mice ; Diet, High-Fat ; Metabolic Diseases/drug therapy ; Mice, Inbred C57BL ; Neurons/drug effects ; Neurons/pathology ; Receptors, Fibroblast Growth Factor/metabolism ; Ventral Tegmental Area/drug effects ; Ventral Tegmental Area/pathology ; Recombinant Proteins/administration & dosage
Czasopismo naukowe
Szczegóły
Tytuł:
Letter to the editor: Nuances from the manufacturer regarding the ABCD-DTN best practice guide on the use of MiniMed 780G advanced hybrid closed loop system.
Autorzy:
van den Heuvel T; Medtronic International Trading Sàrl, Tolochenaz, Switzerland.
Castaneda J; Medtronic International Trading Sàrl, Tolochenaz, Switzerland.
Arrieta A; Medtronic International Trading Sàrl, Tolochenaz, Switzerland.
Cohen O; Medtronic International Trading Sàrl, Tolochenaz, Switzerland.
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Źródło:
Diabetic medicine : a journal of the British Diabetic Association [Diabet Med] 2023 Sep; Vol. 40 (9), pp. e15171. Date of Electronic Publication: 2023 Jul 12.
Typ publikacji:
Letter; Research Support, Non-U.S. Gov't; Comment
MeSH Terms:
Hypoglycemic Agents*/therapeutic use
Diabetes Mellitus, Type 1*/drug therapy
Humans ; Insulin/therapeutic use ; Insulin Infusion Systems ; Blood Glucose ; Blood Glucose Self-Monitoring
Raport
Szczegóły
Tytuł:
Tirzepatide 10 and 15 mg compared with semaglutide 2.4 mg for the treatment of obesity: An indirect treatment comparison.
Autorzy:
le Roux CW; Diabetes Complications Research Centre, University College Dublin, Dublin, Ireland.
Hankosky ER; Eli Lilly and Company, Indianapolis, Indiana, USA.
Wang D; Eli Lilly and Company, Indianapolis, Indiana, USA.
Malik R; Eli Lilly and Company, Indianapolis, Indiana, USA.
Yu M; Eli Lilly and Company, Indianapolis, Indiana, USA.
Hickey A; Eli Lilly and Company, Indianapolis, Indiana, USA.
Kan H; Eli Lilly and Company, Indianapolis, Indiana, USA.
Bunck MC; Eli Lilly and Company, Indianapolis, Indiana, USA.
Stefanski A; Eli Lilly and Company, Indianapolis, Indiana, USA.
Garcia-Perez LE; Eli Lilly and Company, Indianapolis, Indiana, USA.
Wharton S; McMaster University, York University and Wharton Weight Management Clinic, Toronto, Ontario, Canada.
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Źródło:
Diabetes, obesity & metabolism [Diabetes Obes Metab] 2023 Sep; Vol. 25 (9), pp. 2626-2633. Date of Electronic Publication: 2023 Jun 21.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Hypoglycemic Agents*
Diabetes Mellitus, Type 2*
Humans ; Glucagon-Like Peptides/adverse effects ; Obesity/drug therapy ; Body Weight ; Weight Loss
Czasopismo naukowe
Szczegóły
Tytuł:
iPADD: A Computational Tool for Predicting Potential Antidiabetic Drugs Using Machine Learning Algorithms.
Autorzy:
Liu XW; School of Life Science and Technology and Center for Informational Biology, University of Electronic Science and Technology of China, Chengdu 610054, China.
Shi TY; School of Life Science and Technology and Center for Informational Biology, University of Electronic Science and Technology of China, Chengdu 610054, China.
Gao D; School of Life Science and Technology and Center for Informational Biology, University of Electronic Science and Technology of China, Chengdu 610054, China.
Ma CY; School of Life Science and Technology and Center for Informational Biology, University of Electronic Science and Technology of China, Chengdu 610054, China.
Lin H; School of Life Science and Technology and Center for Informational Biology, University of Electronic Science and Technology of China, Chengdu 610054, China.
Yan D; Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.; Beijing Institute of Clinical Pharmacy, Beijing 100050, China.
Deng KJ; School of Life Science and Technology and Center for Informational Biology, University of Electronic Science and Technology of China, Chengdu 610054, China.
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Źródło:
Journal of chemical information and modeling [J Chem Inf Model] 2023 Aug 14; Vol. 63 (15), pp. 4960-4969. Date of Electronic Publication: 2023 Jul 27.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Hypoglycemic Agents*/pharmacology
Artificial Intelligence*
Molecular Docking Simulation ; Algorithms ; Machine Learning
Czasopismo naukowe
Szczegóły
Tytuł:
Renal Glucose Release after Unilateral Renal Denervation during a Hypoglycemic Clamp in Pigs with an Altered Hypothalamic Pituitary Adrenal Axis after Late-Gestational Dexamethasone Injection.
Autorzy:
Nistor M; Orthopaedic Department, Jena University Hospital, Campus Eisenberg, 07607 Eisenberg, Germany.
Schmidt M; Institute for Biochemistry II, Jena University Hospital, 07743 Jena, Germany.
Klingner C; Department of Neurology, Jena University Hospital, 07747 Jena, Germany.
Klingner C; Department of Neurology, Jena University Hospital, 07747 Jena, Germany.
Schwab M; Department of Neurology, Jena University Hospital, 07747 Jena, Germany.
Bischoff SJ; Institute for Laboratory Animals and Welfare, Jena University Hospital, 07743 Jena, Germany.
Matziolis G; Orthopaedic Department, Jena University Hospital, Campus Eisenberg, 07607 Eisenberg, Germany.
Rodríguez-González GL; Reproductive Biology, National Institute of Medical Science and Nutrition, 14080 Mexico City, Mexico.
Schiffner R; Orthopaedic Department, Jena University Hospital, Campus Eisenberg, 07607 Eisenberg, Germany.; Emergency Department, Otto-von-Guericke University, 39120 Magdeburg, Germany.; Emergency Department, Helios University Clinic Wuppertal, 42283 Wuppertal, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Aug 13; Vol. 24 (16). Date of Electronic Publication: 2023 Aug 13.
Typ publikacji:
Journal Article
MeSH Terms:
Hypoglycemic Agents*
Hypoglycemia*
Female ; Animals ; Swine ; Pregnancy ; Glucose ; Hypothalamo-Hypophyseal System ; Inulin ; Pituitary-Adrenal System ; p-Aminohippuric Acid ; Dexamethasone/adverse effects ; Denervation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
2,3-Seco and 3-nor guaianolides fromAchillea alpina with antidiabetic activity.
Autorzy:
Xue G; College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China. Electronic address: .
Zhao C; College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China.
Xue J; College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China.
Duan J; College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China.
Pan H; College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China.
Zhao X; College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China.
Yang Z; College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China.
Chen H; College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China.
Sun Y; College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China.
Feng W; College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China. Electronic address: .
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Źródło:
Chinese journal of natural medicines [Chin J Nat Med] 2023 Aug; Vol. 21 (8), pp. 610-618.
Typ publikacji:
Journal Article
MeSH Terms:
Hypoglycemic Agents*/pharmacology
Insulin Resistance*
Humans ; Circular Dichroism ; Cytokines ; Glucose ; Hep G2 Cells
Czasopismo naukowe
Szczegóły
Tytuł:
Influence of semaglutide use on the presence of residual gastric solids on gastric ultrasound: a prospective observational study in volunteers without obesity recently started on semaglutide.
Autorzy:
Sherwin M; Department of Anesthesiology, Perioperative and Pain Medicine, Icahn School of Medicine at Mount Sinai, 1 Gustave L., Levy Place, Box 1010, New York, NY, 10029, USA.
Hamburger J; Department of Anesthesiology, Perioperative and Pain Medicine, Icahn School of Medicine at Mount Sinai, 1 Gustave L., Levy Place, Box 1010, New York, NY, 10029, USA.
Katz D; Department of Anesthesiology, Perioperative and Pain Medicine, Icahn School of Medicine at Mount Sinai, 1 Gustave L., Levy Place, Box 1010, New York, NY, 10029, USA.
DeMaria S Jr; Department of Anesthesiology, Perioperative and Pain Medicine, Icahn School of Medicine at Mount Sinai, 1 Gustave L., Levy Place, Box 1010, New York, NY, 10029, USA. .
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Transliterated Title:
Influence de l’utilisation du sémaglutide sur la présence de solides gastriques résiduels à l’échographie gastrique : une étude observationnelle prospective auprès de volontaires sans obésité ayant récemment commencé à prendre du sémaglutide.
Źródło:
Canadian journal of anaesthesia = Journal canadien d'anesthesie [Can J Anaesth] 2023 Aug; Vol. 70 (8), pp. 1300-1306. Date of Electronic Publication: 2023 Jul 19.
Typ publikacji:
Observational Study; Journal Article
MeSH Terms:
Hypoglycemic Agents*
Diabetes Mellitus, Type 2*/drug therapy
Adult ; Humans ; Prospective Studies ; Glucagon-Like Peptide-1 Receptor/agonists ; Glucagon-Like Peptide-1 Receptor/therapeutic use ; Obesity ; Volunteers
Czasopismo naukowe
Szczegóły
Tytuł:
Use of metformin and insulin among pregnant women with gestation diabetes in the United Kingdom: A population-based cohort study.
Autorzy:
Yu YH; Department of Population Health Science, Georgia State University, Georgia, USA.
Platt RW; Centre for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, Quebec, Canada.; Departments of Pediatrics and of Epidemiology, Biostatistics and Occupational Health, McGill University, Quebec, Canada.
Reynier P; Centre for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, Quebec, Canada.
Yu OHY; Centre for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, Quebec, Canada.; Division of Endocrinology, Jewish General Hospital, Quebec, Canada.
Filion KB; Centre for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, Quebec, Canada.; Departments of Medicine and of Epidemiology, Biostatistics and Occupational Health, McGill University, Quebec, Canada.
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Źródło:
Diabetic medicine : a journal of the British Diabetic Association [Diabet Med] 2023 Aug; Vol. 40 (8), pp. e15108. Date of Electronic Publication: 2023 Apr 17.
Typ publikacji:
Journal Article
MeSH Terms:
Diabetes, Gestational*/drug therapy
Diabetes, Gestational*/epidemiology
Hypoglycemic Agents*/therapeutic use
Insulin*/therapeutic use
Metformin*/therapeutic use
Pregnancy in Diabetics*/drug therapy
Pregnancy in Diabetics*/epidemiology
Female ; Humans ; Pregnancy ; Cohort Studies ; Pregnant Women
Czasopismo naukowe
Szczegóły
Tytuł:
Reducing BMI below the obesity threshold in adolescents treated with once-weekly subcutaneous semaglutide 2.4 mg.
Autorzy:
Kelly AS; Department of Pediatrics and Center for Pediatric Obesity Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
Arslanian S; Division of Pediatric Endocrinology, Diabetes and Metabolism, Center for Pediatric Research in Obesity and Metabolism, University of Pittsburgh School of Medicine, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Hesse D; Novo Nordisk A/S, Søborg, Denmark.
Iversen AT; Novo Nordisk A/S, Søborg, Denmark.
Körner A; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany.; Center for Pediatric Research (CPL), Leipzig University, Medical Faculty, Hospital for Children and Adolescents, Leipzig, Germany.
Schmidt S; Novo Nordisk A/S, Søborg, Denmark.
Sørrig R; Novo Nordisk A/S, Søborg, Denmark.
Weghuber D; Department of Pediatrics, Paracelsus Medical University, Salzburg, Austria.
Jastreboff AM; Department of Medicine (Endocrinology and Metabolism) and Department of Pediatrics (Pediatric Endocrinology), Yale University School of Medicine, New Haven, Connecticut, USA.
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Źródło:
Obesity (Silver Spring, Md.) [Obesity (Silver Spring)] 2023 Aug; Vol. 31 (8), pp. 2139-2149. Date of Electronic Publication: 2023 Jul 09.
Typ publikacji:
Randomized Controlled Trial; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Hypoglycemic Agents*/therapeutic use
Diabetes Mellitus, Type 2*/drug therapy
Humans ; Adolescent ; Body Mass Index ; Overweight/drug therapy ; Treatment Outcome ; Obesity/drug therapy ; Double-Blind Method
Czasopismo naukowe
Szczegóły
Tytuł:
A pharmacokinetic study to correlate the hypoglycemic effect of phlorizin in rats: Identification of metabolites as inhibitors of sodium/glucose cotransporters.
Autorzy:
Borkar RM; Analytical Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad, India.; Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research (NIPER), Guwahati, India.
Kanwal A; Non-Communicable Diseases Group, Translational Health Science and Technology Institute (THSTI), Faridabad, India.; Department of Pharmacology, All India Institute of Medical Sciences, Bathinda, India.
Raju B; Analytical Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad, India.
Pulimamidi SS; Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research (NIPER), Guwahati, India.
Das AP; Bioinformatics Division, ICMR-National Institute of Cancer Prevention and Research, Noida, India.
Agarwal SM; Bioinformatics Division, ICMR-National Institute of Cancer Prevention and Research, Noida, India.
Banerjee SK; Non-Communicable Diseases Group, Translational Health Science and Technology Institute (THSTI), Faridabad, India.; Department of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER), Guwahati, India.
Srinivas R; Analytical Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad, India.
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Źródło:
Journal of mass spectrometry : JMS [J Mass Spectrom] 2023 Aug; Vol. 58 (8), pp. e4964.
Typ publikacji:
Journal Article
MeSH Terms:
Hypoglycemic Agents*/pharmacology
Diabetes Mellitus, Type 2*
Rats ; Animals ; Rats, Sprague-Dawley ; Tandem Mass Spectrometry/methods ; Sodium-Glucose Transporter 2 ; Phlorhizin/pharmacology ; Spectrometry, Mass, Electrospray Ionization/methods ; Glucose/metabolism ; Sodium ; Chromatography, High Pressure Liquid/methods
Czasopismo naukowe
Szczegóły
Wyświetlanie 1-20 z 60450

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