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Wyszukujesz frazę ""Hypoxia"" wg kryterium: Temat


Starter badań:

Tytuł:
ISGylation directly modifies hypoxia-inducible factor-2α and enhances its polysome association.
Autorzy:
Melanson G; Department of Molecular and Cellular Biology, University of Guelph, Canada.
Du Bois AC; Department of Molecular and Cellular Biology, University of Guelph, Canada.
Webster C; Department of Molecular and Cellular Biology, University of Guelph, Canada.
Uniacke J; Department of Molecular and Cellular Biology, University of Guelph, Canada.
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Źródło:
FEBS letters [FEBS Lett] 2022 Nov; Vol. 596 (21), pp. 2834-2850. Date of Electronic Publication: 2022 Sep 02.
Typ publikacji:
Journal Article
MeSH Terms:
Basic Helix-Loop-Helix Transcription Factors*/genetics
Basic Helix-Loop-Helix Transcription Factors*/immunology
Hypoxia*/genetics
Hypoxia*/immunology
Polyribosomes*/genetics
Polyribosomes*/immunology
Humans ; Cell Hypoxia/genetics ; Cell Hypoxia/immunology ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Hypoxia-Inducible Factor 1, alpha Subunit/immunology ; Interferons/genetics ; Interferons/immunology
Czasopismo naukowe
Tytuł:
Intermittent hypoxia enhances the expression of hypoxia inducible factor HIF1A through histone demethylation.
Autorzy:
Martinez CA; The University of Sydney, Faculty of Medicine and Health, Charles Perkins Centre, Sydney, New South Wales, Australia.
Jiramongkol Y; The University of Sydney, Faculty of Science, Charles Perkins Centre, Sydney, New South Wales, Australia; The University of Sydney, School of Chemistry, Sydney, New South Wales, Australia.
Bal N; The University of Sydney, Faculty of Medicine and Health, Charles Perkins Centre, Sydney, New South Wales, Australia.
Alwis I; The University of Sydney, Faculty of Medicine and Health, Charles Perkins Centre, Sydney, New South Wales, Australia; Heart Research Institute, The University of Sydney, Sydney, New South Wales, Australia.
Nedoboy PE; The University of Sydney, Faculty of Medicine and Health, Charles Perkins Centre, Sydney, New South Wales, Australia; Heart Research Institute, The University of Sydney, Sydney, New South Wales, Australia.
Farnham MMJ; The University of Sydney, Faculty of Medicine and Health, Charles Perkins Centre, Sydney, New South Wales, Australia; Heart Research Institute, The University of Sydney, Sydney, New South Wales, Australia.
White MD; The University of Sydney, Faculty of Science, Charles Perkins Centre, Sydney, New South Wales, Australia; The University of Sydney, School of Chemistry, Sydney, New South Wales, Australia.
Cistulli PA; The University of Sydney, Faculty of Medicine and Health, Charles Perkins Centre, Sydney, New South Wales, Australia.
Cook KM; The University of Sydney, Faculty of Medicine and Health, Charles Perkins Centre, Sydney, New South Wales, Australia. Electronic address: .
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Źródło:
The Journal of biological chemistry [J Biol Chem] 2022 Nov; Vol. 298 (11), pp. 102536. Date of Electronic Publication: 2022 Sep 27.
Typ publikacji:
Journal Article
MeSH Terms:
Histones*/genetics
Histones*/metabolism
Hypoxia-Inducible Factor 1, alpha Subunit*/genetics
Hypoxia-Inducible Factor 1, alpha Subunit*/metabolism
Protein Processing, Post-Translational*
Humans ; Demethylation ; Histone Demethylases/metabolism ; Hypoxia ; Jumonji Domain-Containing Histone Demethylases/genetics ; Jumonji Domain-Containing Histone Demethylases/metabolism ; Oxygen/metabolism
Czasopismo naukowe
Tytuł:
Improving lipophilicity of 5-(1-acetyl-5-phenylpyrazolidin-3-ylidene)-1,3-dimethylbarbituric acid increases its efficacy to activate hypoxia-inducible factors.
Autorzy:
Sonoda K; Center for Education and Research in Agricultural Innovation, Faculty of Agriculture, Saga University, 152-1 Shonan-cho, Karatsu, Saga 847-0021, Japan; Laboratory of Biochemistry, Department of Applied Biochemistry and Food Science, Faculty of Agriculture, Saga University, 1 Honjo-machi, Saga 840-8502, Japan; The United Graduate School of Agricultural Sciences, Kagoshima University, 1-21-24, Korimoto, Kagoshima 890-0065, Japan.
Ujike S; Center for Education and Research in Agricultural Innovation, Faculty of Agriculture, Saga University, 152-1 Shonan-cho, Karatsu, Saga 847-0021, Japan; Graduate School of Advanced Health Sciences, Saga University, 152-1 Shonan-cho, Karatsu, Saga 847-0021, Japan.
Katayama A; Center for Education and Research in Agricultural Innovation, Faculty of Agriculture, Saga University, 152-1 Shonan-cho, Karatsu, Saga 847-0021, Japan.
Suzuki N; Division of Oxygen Biology, United Centers for Advanced Research and Translational Medicine, Tohoku University Graduate School of Medicine; Applied Oxygen Physiology Project, New Industry Creation Hatchery Center (NICHe), Tohoku University, 2-1 Seiryo-machi, Aobaku, Sendai, Miyagi 980-8575, Japan.
Kawaguchi SI; Center for Education and Research in Agricultural Innovation, Faculty of Agriculture, Saga University, 152-1 Shonan-cho, Karatsu, Saga 847-0021, Japan; The United Graduate School of Agricultural Sciences, Kagoshima University, 1-21-24, Korimoto, Kagoshima 890-0065, Japan; Graduate School of Advanced Health Sciences, Saga University, 152-1 Shonan-cho, Karatsu, Saga 847-0021, Japan. Electronic address: .
Tsujita T; Laboratory of Biochemistry, Department of Applied Biochemistry and Food Science, Faculty of Agriculture, Saga University, 1 Honjo-machi, Saga 840-8502, Japan; The United Graduate School of Agricultural Sciences, Kagoshima University, 1-21-24, Korimoto, Kagoshima 890-0065, Japan; Graduate School of Advanced Health Sciences, Saga University, 152-1 Shonan-cho, Karatsu, Saga 847-0021, Japan. Electronic address: .
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Źródło:
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2022 Nov 01; Vol. 73, pp. 117039. Date of Electronic Publication: 2022 Sep 29.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Hypoxia*
Ketoglutaric Acids*
Barbiturates ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit ; Hypoxia-Inducible Factor-Proline Dioxygenases
Czasopismo naukowe
Tytuł:
The optimal 18F-fluoromisonidazole PET threshold to define tumor hypoxia in preclinical squamous cell carcinomas using pO2 electron paramagnetic resonance imaging as reference truth.
Autorzy:
Gertsenshteyn I; Department of Radiology, The University of Chicago, Chicago, IL, USA.; Department of Radiation and Cellular Oncology, The University of Chicago, Chicago, IL, USA.; Center for EPR Imaging In Vivo Physiology, The University of Chicago, Chicago, IL, USA.
Epel B; Department of Radiation and Cellular Oncology, The University of Chicago, Chicago, IL, USA.; Center for EPR Imaging In Vivo Physiology, The University of Chicago, Chicago, IL, USA.
Ahluwalia A; Department of Radiology, The University of Chicago, Chicago, IL, USA.
Kim H; Department of Radiology, The University of Chicago, Chicago, IL, USA.
Fan X; Department of Radiology, The University of Chicago, Chicago, IL, USA.; Integrated Small Animal Imaging Research Resource, OSRF, The University of Chicago, Chicago, IL, USA.
Barth E; Department of Radiation and Cellular Oncology, The University of Chicago, Chicago, IL, USA.; Center for EPR Imaging In Vivo Physiology, The University of Chicago, Chicago, IL, USA.
Zamora M; Department of Radiology, The University of Chicago, Chicago, IL, USA.; Integrated Small Animal Imaging Research Resource, OSRF, The University of Chicago, Chicago, IL, USA.
Markiewicz E; Integrated Small Animal Imaging Research Resource, OSRF, The University of Chicago, Chicago, IL, USA.
Tsai HM; Integrated Small Animal Imaging Research Resource, OSRF, The University of Chicago, Chicago, IL, USA.
Sundramoorthy S; Department of Radiation and Cellular Oncology, The University of Chicago, Chicago, IL, USA.; Center for EPR Imaging In Vivo Physiology, The University of Chicago, Chicago, IL, USA.
Leoni L; Integrated Small Animal Imaging Research Resource, OSRF, The University of Chicago, Chicago, IL, USA.
Lukens J; Department of Radiation and Cellular Oncology, The University of Chicago, Chicago, IL, USA.; Center for EPR Imaging In Vivo Physiology, The University of Chicago, Chicago, IL, USA.
Bhuiyan M; Department of Radiology, The University of Chicago, Chicago, IL, USA.
Freifelder R; Department of Radiology, The University of Chicago, Chicago, IL, USA.
Kucharski A; Department of Radiology, The University of Chicago, Chicago, IL, USA.
Giurcanu M; Department of Public Health Sciences, The University of Chicago, Chicago, IL, USA.
Roman BB; Department of Radiology, The University of Chicago, Chicago, IL, USA.; Integrated Small Animal Imaging Research Resource, OSRF, The University of Chicago, Chicago, IL, USA.
Karczmar G; Department of Radiology, The University of Chicago, Chicago, IL, USA.; Integrated Small Animal Imaging Research Resource, OSRF, The University of Chicago, Chicago, IL, USA.
Kao CM; Department of Radiology, The University of Chicago, Chicago, IL, USA.; Integrated Small Animal Imaging Research Resource, OSRF, The University of Chicago, Chicago, IL, USA.
Halpern H; Department of Radiation and Cellular Oncology, The University of Chicago, Chicago, IL, USA.; Center for EPR Imaging In Vivo Physiology, The University of Chicago, Chicago, IL, USA.
Chen CT; Department of Radiology, The University of Chicago, Chicago, IL, USA. .; Integrated Small Animal Imaging Research Resource, OSRF, The University of Chicago, Chicago, IL, USA. .
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Źródło:
European journal of nuclear medicine and molecular imaging [Eur J Nucl Med Mol Imaging] 2022 Oct; Vol. 49 (12), pp. 4014-4024. Date of Electronic Publication: 2022 Jul 06.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Squamous Cell*/diagnostic imaging
Carcinoma, Squamous Cell*/pathology
Tumor Hypoxia*
Animals ; Cell Hypoxia ; Electron Spin Resonance Spectroscopy ; Hypoxia/diagnostic imaging ; Mice ; Misonidazole/analogs & derivatives ; Positron-Emission Tomography/methods ; Radiopharmaceuticals ; Tomography, X-Ray Computed
Czasopismo naukowe
Tytuł:
Caveolin-1 suppresses hippocampal neuron apoptosis via the regulation of HIF1α in hypoxia in naked mole-rats.
Autorzy:
Yang W; Department of Laboratory Animal Sciences, School of Basic Medicine, Naval Medical University, Shanghai, China.
Wu W; Department of Laboratory Animal Center, Academy of Military Medical Sciences, Beijing, China.
Zhao Y; Shanghai Laboratory Animal Research Center, Shanghai, China.
Li Y; Department of Laboratory Animal Sciences, School of Basic Medicine, Naval Medical University, Shanghai, China.
Zhang C; Department of Laboratory Animal Sciences, School of Basic Medicine, Naval Medical University, Shanghai, China.
Zhang J; Department of Laboratory Animal Sciences, School of Basic Medicine, Naval Medical University, Shanghai, China.
Chen C; Department of Laboratory Animal Sciences, School of Basic Medicine, Naval Medical University, Shanghai, China.
Cui S; Department of Laboratory Animal Sciences, School of Basic Medicine, Naval Medical University, Shanghai, China.
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Źródło:
Cell biology international [Cell Biol Int] 2022 Dec; Vol. 46 (12), pp. 2060-2074. Date of Electronic Publication: 2022 Sep 02.
Typ publikacji:
Journal Article
MeSH Terms:
Caveolin 1*/metabolism
Hypoxia*/metabolism
Animals ; Mole Rats/metabolism ; Hippocampus/metabolism ; Apoptosis ; Neurons/metabolism ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism
Czasopismo naukowe
Tytuł:
Continuous monitoring of postirradiation reoxygenation and cycling hypoxia using electron paramagnetic resonance imaging.
Autorzy:
Kawai T; Radiation Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA.; Department of Radiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Matsuo M; Radiation Biology Branch, National Cancer Institute, Bethesda, Maryland, USA.; Department of Radiology, Gifu University, Gifu, Japan.
Takakusagi Y; Radiation Biology Branch, National Cancer Institute, Bethesda, Maryland, USA.; Institute for Quantum Life Science, National Institutes for Quantum Science and Technology, Chiba-city, Japan.
Saito K; Radiation Biology Branch, National Cancer Institute, Bethesda, Maryland, USA.
Hyodo F; Radiation Biology Branch, National Cancer Institute, Bethesda, Maryland, USA.; Department of Radiology, Frontier Science for Imaging, Gifu University, Gifu, Japan.
Devasahayam N; Radiation Biology Branch, National Cancer Institute, Bethesda, Maryland, USA.
Matsumoto S; Radiation Biology Branch, National Cancer Institute, Bethesda, Maryland, USA.; Division of Bioengineering and Bioinformatics, Graduate School of Information Science and Technology, Hokkaido University, Hokkaido, Japan.
Kishimoto S; Radiation Biology Branch, National Cancer Institute, Bethesda, Maryland, USA.
Yasui H; Radiation Biology Branch, National Cancer Institute, Bethesda, Maryland, USA.; Laboratory of Radiation Biology, Department of Applied Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Hokkaido, Japan.
Yamamoto K; Radiation Biology Branch, National Cancer Institute, Bethesda, Maryland, USA.
Krishna MC; Radiation Biology Branch, National Cancer Institute, Bethesda, Maryland, USA.
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Źródło:
NMR in biomedicine [NMR Biomed] 2022 Oct; Vol. 35 (10), pp. e4783. Date of Electronic Publication: 2022 Jun 27.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Intramural
MeSH Terms:
Hypoxia*
Neoplasms*
Animals ; Cell Hypoxia ; Electron Spin Resonance Spectroscopy/methods ; Female ; Humans ; Mice ; Mice, Nude ; Oxygen/metabolism ; Tumor Microenvironment
Czasopismo naukowe
Tytuł:
Dynamic magnetic resonance imaging findings in the early stages of neonatal hypoglycemic brain injury.
Autorzy:
Zhang Y; Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China.
Chen D; Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China.
Ji Y; Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China.
Yu W; Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China.
Mao J; Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China. .
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Źródło:
European journal of pediatrics [Eur J Pediatr] 2022 Dec; Vol. 181 (12), pp. 4167-4174. Date of Electronic Publication: 2022 Sep 27.
Typ publikacji:
Journal Article
MeSH Terms:
Hypoglycemia*/etiology
Hypoglycemia*/complications
Brain Injuries*/etiology
Brain Injuries*/complications
Hypoxia-Ischemia, Brain*/diagnostic imaging
Hypoxia-Ischemia, Brain*/complications
Infant ; Infant, Newborn ; Humans ; Hypoglycemic Agents ; Retrospective Studies ; Magnetic Resonance Imaging/methods ; Diffusion Magnetic Resonance Imaging/methods ; Hypoxia/complications ; Brain/diagnostic imaging ; Brain/pathology
Czasopismo naukowe
Tytuł:
Hypoxia: molecular pathophysiological mechanisms in human diseases.
Autorzy:
Della Rocca Y; Department of Innovative Technologies in Medicine & Dentistry, University 'G. d'Annunzio' Chieti-Pescara, Chieti, Italy.
Fonticoli L; Department of Innovative Technologies in Medicine & Dentistry, University 'G. d'Annunzio' Chieti-Pescara, Chieti, Italy.
Rajan TS; Department of Biotechnology, Karpagam Academy of Higher Education, Coimbatore, India.
Trubiani O; Department of Innovative Technologies in Medicine & Dentistry, University 'G. d'Annunzio' Chieti-Pescara, Chieti, Italy.
Caputi S; Department of Innovative Technologies in Medicine & Dentistry, University 'G. d'Annunzio' Chieti-Pescara, Chieti, Italy.
Diomede F; Department of Innovative Technologies in Medicine & Dentistry, University 'G. d'Annunzio' Chieti-Pescara, Chieti, Italy. .
Pizzicannella J; Cardiology Intensive Care Unit, 'Ss. Annunziata' Hospital, ASL02 Lanciano-Vasto-Chieti, Chieti, Italy.
Marconi GD; Department of Medical, Oral and Biotechnological Sciences, University 'G. d'Annunzio' Chieti-Pescara, Chieti, Italy.
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Źródło:
Journal of physiology and biochemistry [J Physiol Biochem] 2022 Nov; Vol. 78 (4), pp. 739-752. Date of Electronic Publication: 2022 Jul 23.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Hypoxia*/metabolism
Lung Diseases*
Humans ; Cell Hypoxia ; Cell Proliferation ; Neoplastic Stem Cells/metabolism
Czasopismo naukowe
Tytuł:
Crucial Role of RLIP76 in Promoting Glycolysis and Tumorigenesis by Stabilization of HIF-1α in Glioma Cells Under Hypoxia.
Autorzy:
Wang Q; Department of Neurosurgery, Shanghai Tongji Hospital, Tongji University School of Medicine, 389 Xincun Road, Shanghai, China.
Zhang C; Department of Neurosurgery, Shanghai Tongji Hospital, Tongji University School of Medicine, 389 Xincun Road, Shanghai, China.
Zhu J; Department of Neurosurgery, Shanghai Tongji Hospital, Tongji University School of Medicine, 389 Xincun Road, Shanghai, China.
Zhang L; Department of Neurosurgery, Shanghai Tongji Hospital, Tongji University School of Medicine, 389 Xincun Road, Shanghai, China.
Chen H; Department of Neurosurgery, Shanghai Tongji Hospital, Tongji University School of Medicine, 389 Xincun Road, Shanghai, China.
Qian J; Department of Neurosurgery, Shanghai Tongji Hospital, Tongji University School of Medicine, 389 Xincun Road, Shanghai, China.
Luo C; Department of Neurosurgery, Shanghai Tongji Hospital, Tongji University School of Medicine, 389 Xincun Road, Shanghai, China. .
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Źródło:
Molecular neurobiology [Mol Neurobiol] 2022 Nov; Vol. 59 (11), pp. 6724-6739. Date of Electronic Publication: 2022 Aug 23.
Typ publikacji:
Journal Article
MeSH Terms:
ATP-Binding Cassette Transporters*/metabolism
GTPase-Activating Proteins*/metabolism
Glioma*/metabolism
Glycolysis*
Hypoxia-Inducible Factor 1, alpha Subunit*/metabolism
Carcinogenesis ; Cell Hypoxia ; Glucose Transporter Type 1/metabolism ; Humans ; Lactate Dehydrogenase 5 ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł:
A systematic review of noninflammatory cerebrospinal fluid biomarkers for clinical outcome in neonates with perinatal hypoxic brain injury that could be biologically significant.
Autorzy:
Shi Z; Department of Pediatrics, Wayne State University, Detroit, MI, USA.
Luo K; Department of Pediatrics, Wayne State University, Detroit, MI, USA.
Deol S; Department of Psychology, College of Liberal Arts & Sciences, Wayne State University, Detroit, MI, USA.
Tan S; Department of Pediatrics, Wayne State University, Detroit, MI, USA.
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Źródło:
Journal of neuroscience research [J Neurosci Res] 2022 Dec; Vol. 100 (12), pp. 2154-2173. Date of Electronic Publication: 2021 Feb 04.
Typ publikacji:
Systematic Review; Journal Article; Review
MeSH Terms:
Asphyxia Neonatorum*
Hypoxia-Ischemia, Brain*
Female ; Humans ; Infant, Newborn ; Pregnancy ; Biomarkers/cerebrospinal fluid ; Creatine Kinase ; Hypoxia ; Malondialdehyde ; Oxidants ; Phosphopyruvate Hydratase ; Superoxide Dismutase ; Vascular Endothelial Growth Factor A ; Xanthine Oxidase
Czasopismo naukowe
Tytuł:
HIF-1α and Caspase-3 expression in aggressive papillary thyroid carcinoma.
Autorzy:
Zhang L; Department of Ultrasound, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Shi B; Department of Ultrasound, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Hu M; Department of Ultrasound, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Qian L; Department of Ultrasound, Beijing Friendship Hospital, Capital Medical University, Beijing, China. .
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Źródło:
World journal of surgical oncology [World J Surg Oncol] 2022 Nov 04; Vol. 20 (1), pp. 353. Date of Electronic Publication: 2022 Nov 04.
Typ publikacji:
Journal Article
MeSH Terms:
Hypoxia-Inducible Factor 1, alpha Subunit*
Thyroid Neoplasms*/pathology
Humans ; Thyroid Cancer, Papillary ; Caspase 3 ; Immunohistochemistry ; Hypoxia
Czasopismo naukowe
Tytuł:
Sensorimotor development of male and female rats subjected to neonatal anoxia.
Autorzy:
Kumar AJ; Neuroscience Laboratory, Department of Anatomy, Institute of Biomedical Sciences, Universidade de São Paulo, São Paulo, Brazil.
Helou AY; Neuroscience Laboratory, Department of Anatomy, Institute of Biomedical Sciences, Universidade de São Paulo, São Paulo, Brazil.
Petrucelli BA; Neuroscience Laboratory, Department of Anatomy, Institute of Biomedical Sciences, Universidade de São Paulo, São Paulo, Brazil.
Xavier GF; Department of Physiology, Institute of Biosciences, Universidade de São Paulo, São Paulo, Brazil.
Martins DO; Laboratory of Neuroanatomy Functional of Pain, Departamento de Anatomia, Instituto de Ciencias Biomedicas, Universidade de São Paulo, São Paulo, Brazil.
Chacur M; Laboratory of Neuroanatomy Functional of Pain, Departamento de Anatomia, Instituto de Ciencias Biomedicas, Universidade de São Paulo, São Paulo, Brazil.
Nogueira MI; Neuroscience Laboratory, Department of Anatomy, Institute of Biomedical Sciences, Universidade de São Paulo, São Paulo, Brazil.
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Źródło:
Developmental psychobiology [Dev Psychobiol] 2022 Nov; Vol. 64 (7), pp. e22291.
Typ publikacji:
Journal Article
MeSH Terms:
Hypoxia-Ischemia, Brain*
Humans ; Infant ; Pregnancy ; Animals ; Rats ; Female ; Male ; Rats, Wistar ; Animals, Newborn ; Disease Models, Animal ; Hypoxia
Czasopismo naukowe
Tytuł:
Deep nuclei injury distribution in isolated "basal ganglia-thalamus" (BGT) versus combined "BGT and watershed" patterns of hypoxic-ischaemic injury (HII) in children with cerebral palsy.
Autorzy:
Elsingergy MM; Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA. Electronic address: .
Worede F; Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
Venkatakrishna S; Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
Andronikou S; Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
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Źródło:
Clinical radiology [Clin Radiol] 2022 Nov; Vol. 77 (11), pp. 825-832. Date of Electronic Publication: 2022 May 29.
Typ publikacji:
Journal Article
MeSH Terms:
Cerebral Palsy*/etiology
Cerebral Palsy*/pathology
Hypoxia-Ischemia, Brain*/diagnostic imaging
Basal Ganglia/diagnostic imaging ; Basal Ganglia/pathology ; Child ; Humans ; Hypoxia/complications ; Infant, Newborn ; Ischemia/complications ; Magnetic Resonance Imaging/adverse effects ; Thalamus/diagnostic imaging ; Thalamus/pathology
Czasopismo naukowe
Tytuł:
Semi-mechanistic Modeling of Hypoxanthine, Xanthine, and Uric Acid Metabolism in Asphyxiated Neonates.
Autorzy:
Chu WY; Department of Pharmacy and Pharmacology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Allegaert K; Department of Development and Regeneration, and Department of Pharmaceutical and Pharmacological Sciences, Leuven, Belgium.; Department of Clinical Pharmacy, Erasmus MC, Rotterdam, The Netherlands.
Dorlo TPC; Department of Pharmacy and Pharmacology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Huitema ADR; Department of Pharmacy and Pharmacology, Netherlands Cancer Institute, Amsterdam, The Netherlands. .; Department of Pharmacology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands. .; Department of Clinical Pharmacy, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands. .
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Corporate Authors:
ALBINO Study Group
Źródło:
Clinical pharmacokinetics [Clin Pharmacokinet] 2022 Nov; Vol. 61 (11), pp. 1545-1558. Date of Electronic Publication: 2022 Aug 30.
Typ publikacji:
Journal Article
MeSH Terms:
Hypoxia-Ischemia, Brain*/drug therapy
Oxypurinol*/pharmacology
Humans ; Infant, Newborn ; Allopurinol/pharmacology ; Allopurinol/therapeutic use ; Hypoxanthine ; Hypoxia/drug therapy ; Mannitol ; Uric Acid ; Xanthine ; Xanthine Dehydrogenase ; Clinical Studies as Topic
Czasopismo naukowe
Tytuł:
Genetically Encoded Whole Cell Biosensor for Drug Discovery of HIF-1 Interaction Inhibitors.
Autorzy:
Scott LH; Discovery Sciences, Biopharmaceuticals R&D, AstraZeneca, SE-41320 Gothenburg, Sweden.; Department of Biology and Biological Engineering, Division of Systems and Synthetic Biology, Chalmers University of Technology, SE-41296 Gothenburg, Sweden.
Wigglesworth MJ; Discovery Sciences, Biopharmaceuticals R&D, AstraZeneca, Alderley Park SK10 2NA, U.K.
Siewers V; Department of Biology and Biological Engineering, Division of Systems and Synthetic Biology, Chalmers University of Technology, SE-41296 Gothenburg, Sweden.
Davis AM; Discovery Sciences, Biopharmaceutical R&D, AstraZeneca, Cambridge, CB2 0AA, U.K.
David F; Department of Biology and Biological Engineering, Division of Systems and Synthetic Biology, Chalmers University of Technology, SE-41296 Gothenburg, Sweden.
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Źródło:
ACS synthetic biology [ACS Synth Biol] 2022 Oct 21; Vol. 11 (10), pp. 3182-3189. Date of Electronic Publication: 2022 Oct 12.
Typ publikacji:
Journal Article
MeSH Terms:
Hypoxia-Inducible Factor 1*
Biosensing Techniques*
Humans ; Hypoxia ; Drug Discovery ; Trans-Activators
Czasopismo naukowe
Tytuł:
HOCI Probe CPP Induces the Differentiation of Human Dermal Fibroblasts into Vascular Endothelial Cells through PHD2/HIF-1α/HEY1 Signaling Pathway.
Autorzy:
Cui X; Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Science, Shandong University, Qingdao 266237, China.
Wen J; School of Stomatology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, China.
Li N; Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Science, Shandong University, Qingdao 266237, China.
Hao X; Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Science, Shandong University, Qingdao 266237, China.
Zhang S; Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Science, Shandong University, Qingdao 266237, China.
Zhao B; Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China.
Wu X; Engineering Laboratory for Biomaterials and Tissue Regeneration, Ningbo Stomatology Hospital, Ningbo 315040, China.; Savaid Stomatology School, Hangzhou Medical College, Hangzhou 310058, China.
Miao J; Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Science, Shandong University, Qingdao 266237, China.; The Key Laboratory of Cardiovascular Remodeling and Function Research, Shandong University Qilu Hospital, Chinese Ministry of Education and Chinese Ministry of Health, Jinan 250012, China.
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Źródło:
Cells [Cells] 2022 Oct 04; Vol. 11 (19). Date of Electronic Publication: 2022 Oct 04.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Endothelial Cells*/metabolism
Hypoxia-Inducible Factor-Proline Dioxygenases*
Basic Helix-Loop-Helix Transcription Factors/metabolism ; Cell Cycle Proteins/metabolism ; Fibroblasts/metabolism ; Humans ; Hypochlorous Acid/pharmacology ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Procollagen-Proline Dioxygenase/genetics ; Procollagen-Proline Dioxygenase/metabolism ; Prolyl Hydroxylases/metabolism ; Pyrazines ; RNA, Small Interfering/genetics ; Signal Transduction
Czasopismo naukowe
Tytuł:
Inhibition of Malate Dehydrogenase-2 Protects Renal Tubular Epithelial Cells from Anoxia-Reoxygenation-Induced Death or Senescence.
Autorzy:
Eleftheriadis T; Department of Nephrology, Faculty of Medicine, University of Thessaly, 41110 Larissa, Greece.
Pissas G; Department of Nephrology, Faculty of Medicine, University of Thessaly, 41110 Larissa, Greece.
Golfinopoulos S; Department of Nephrology, Faculty of Medicine, University of Thessaly, 41110 Larissa, Greece.
Efthymiadi M; Department of Nephrology, Faculty of Medicine, University of Thessaly, 41110 Larissa, Greece.
Liakopoulos V; Department of Nephrology, Faculty of Medicine, University of Thessaly, 41110 Larissa, Greece.
Stefanidis I; Department of Nephrology, Faculty of Medicine, University of Thessaly, 41110 Larissa, Greece.
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Źródło:
Biomolecules [Biomolecules] 2022 Oct 03; Vol. 12 (10). Date of Electronic Publication: 2022 Oct 03.
Typ publikacji:
Journal Article
MeSH Terms:
Hypoxia-Inducible Factor 1, alpha Subunit*/metabolism
Malate Dehydrogenase*/antagonists & inhibitors
Reperfusion Injury*/metabolism
Humans ; Adenosine Triphosphate/metabolism ; Apoptosis ; beta-Galactosidase/metabolism ; Epithelial Cells/metabolism ; Hypoxia/metabolism ; Interleukin-1beta/metabolism ; Ki-67 Antigen/metabolism ; Pharmaceutical Preparations/metabolism ; Reactive Oxygen Species/metabolism ; Tumor Suppressor Protein p53/metabolism
Czasopismo naukowe
Tytuł:
Hypoxia-Inducible Factor-1α in Rods Is Neuroprotective Following Retinal Detachment.
Autorzy:
Ross BX; Department of Ophthalmology, University of Michigan Medical School, Kellogg Eye Center, Ann Arbor, Michigan, United States.
Jia L; Department of Ophthalmology, University of Michigan Medical School, Kellogg Eye Center, Ann Arbor, Michigan, United States.
Kong D; Department of Ophthalmology, University of Michigan Medical School, Kellogg Eye Center, Ann Arbor, Michigan, United States.
Wang T; Department of Ophthalmology, University of Michigan Medical School, Kellogg Eye Center, Ann Arbor, Michigan, United States.; Department of Ophthalmology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Yao J; Department of Ophthalmology, University of Michigan Medical School, Kellogg Eye Center, Ann Arbor, Michigan, United States.
Hager HM; Department of Ophthalmology, University of Michigan Medical School, Kellogg Eye Center, Ann Arbor, Michigan, United States.
Abcouwer SF; Department of Ophthalmology, University of Michigan Medical School, Kellogg Eye Center, Ann Arbor, Michigan, United States.
Zacks DN; Department of Ophthalmology, University of Michigan Medical School, Kellogg Eye Center, Ann Arbor, Michigan, United States.
Pokaż więcej
Źródło:
Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2022 Oct 03; Vol. 63 (11), pp. 7.
Typ publikacji:
Journal Article
MeSH Terms:
Hypoxia-Inducible Factor 1, alpha Subunit*/genetics
Retinal Detachment*/metabolism
Animals ; Blotting, Western ; Hyaluronic Acid ; Hypoxia ; Mice ; Neuroprotection ; Photoreceptor Cells, Vertebrate/pathology
Czasopismo naukowe
Tytuł:
Neuroprotection of Bone Marrow-Derived Mesenchymal Stem Cell-Derived Extracellular Vesicle-Enclosed miR-410 Correlates with HDAC4 Knockdown in Hypoxic-Ischemic Brain Damage.
Autorzy:
Shen M; Department of Pediatrics, General Hospital of Tianjin Medical University, No. 154, Anshan Road, Heping District, Tianjin, 300050, People's Republic of China. .
Zheng R; Department of Pediatrics, General Hospital of Tianjin Medical University, No. 154, Anshan Road, Heping District, Tianjin, 300050, People's Republic of China.
Kan X; Department of Pediatrics, General Hospital of Tianjin Medical University, No. 154, Anshan Road, Heping District, Tianjin, 300050, People's Republic of China.
Pokaż więcej
Źródło:
Neurochemical research [Neurochem Res] 2022 Oct; Vol. 47 (10), pp. 3150-3166. Date of Electronic Publication: 2022 Aug 26.
Typ publikacji:
Journal Article
MeSH Terms:
Extracellular Vesicles*/metabolism
Hypoxia-Ischemia, Brain*/metabolism
Mesenchymal Stem Cells*/metabolism
MicroRNAs*/genetics
MicroRNAs*/metabolism
Histone Deacetylases/*metabolism
Animals ; Bone Marrow/metabolism ; Brain/metabolism ; Hypoxia/metabolism ; Mice ; Neuroprotection ; beta Catenin/metabolism
Czasopismo naukowe
Tytuł:
HIF-1 stabilization in T cells hampers the control of Mycobacterium tuberculosis infection.
Autorzy:
Liu R; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
Muliadi V; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
Mou W; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.; Capital Children's Hospital, Beijing, China.
Li H; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
Yuan J; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
Holmberg J; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
Chambers BJ; Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
Ullah N; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
Wurth J; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.; University Children's Hospital Zurich, Zurich, Switzerland.
Alzrigat M; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
Schlisio S; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
Carow B; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.; Novovavax AB, Uppsala, Sweden.
Larsson LG; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
Rottenberg ME; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden. .
Pokaż więcej
Źródło:
Nature communications [Nat Commun] 2022 Sep 05; Vol. 13 (1), pp. 5093. Date of Electronic Publication: 2022 Sep 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Hypoxia-Inducible Factor 1, alpha Subunit*/genetics
Hypoxia-Inducible Factor 1, alpha Subunit*/immunology
Tuberculosis*/genetics
Tuberculosis*/immunology
Tuberculosis*/prevention & control
Von Hippel-Lindau Tumor Suppressor Protein*/genetics
Von Hippel-Lindau Tumor Suppressor Protein*/immunology
Animals ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Hypoxia ; Hypoxia-Inducible Factor 1 ; Mice ; T-Lymphocytes/immunology
Czasopismo naukowe

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