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Wyszukujesz frazę ""Hypoxia"" wg kryterium: Temat


Tytuł :
Pterostilbene Nanoparticles Downregulate Hypoxia-Inducible Factors in Hepatoma Cells Under Hypoxic Conditions.
Autorzy :
Tzeng WS; Department of Radiology, Pingtung Christian Hospital, Pingtung, Taiwan.; Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan.
Teng WL; Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan.
Huang PH; School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan.
Lin TC; Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan.
Yen FL; Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan.; Department of Fragrance and Cosmetic Science, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan.; Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Shiue YL; Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan.
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Źródło :
International journal of nanomedicine [Int J Nanomedicine] 2021 Feb 05; Vol. 16, pp. 867-879. Date of Electronic Publication: 2021 Feb 05 (Print Publication: 2021).
Typ publikacji :
Journal Article
MeSH Terms :
Down-Regulation*/drug effects
Tumor Hypoxia*/drug effects
Carcinoma, Hepatocellular/*drug therapy
Hypoxia-Inducible Factor 1, alpha Subunit/*metabolism
Liver Neoplasms/*drug therapy
Nanoparticles/*chemistry
Stilbenes/*therapeutic use
Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Apoptosis/drug effects ; Carcinoma, Hepatocellular/pathology ; Cell Hypoxia/drug effects ; Cell Survival/drug effects ; Crystallization ; Drug Liberation ; Hep G2 Cells ; Humans ; Hydrogen Bonding ; Liver Neoplasms/pathology ; Neoplasm Invasiveness ; Particle Size ; Proton Magnetic Resonance Spectroscopy ; Solubility ; Spectroscopy, Fourier Transform Infrared ; Stilbenes/chemistry ; Stilbenes/pharmacology
Czasopismo naukowe
Tytuł :
[Effects of intermittent hypoxia stimulation with different frequencies on HT22 cell viability and expression of Hif-1α and p-NF-κB].
Autorzy :
Yang SC; Department of Physiology, Hebei University of Chinese Medicine, Shijiazhuang 050200, China.
Zhao Y; Department of Physiology, Hebei University of Chinese Medicine, Shijiazhuang 050200, China.
Zheng YY; Department of Physiology, Hebei University of Chinese Medicine, Shijiazhuang 050200, China.
Li WY; Department of Physiology, Hebei University of Chinese Medicine, Shijiazhuang 050200, China.
Zhao M; Department of Physiology, Hebei University of Chinese Medicine, Shijiazhuang 050200, China.
Ji ES; Department of Physiology, Hebei University of Chinese Medicine, Shijiazhuang 050200, China. .
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Źródło :
Sheng li xue bao : [Acta physiologica Sinica] [Sheng Li Xue Bao] 2021 Feb 25; Vol. 73 (1), pp. 26-34.
Typ publikacji :
Journal Article
MeSH Terms :
Hypoxia*
NF-kappa B*/metabolism
Animals ; Cell Hypoxia ; Cell Survival ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Mice ; Oxidative Stress ; Reactive Oxygen Species
Czasopismo naukowe
Tytuł :
[Genotype and phenotype analysis of neonates with neonatal encephalopathy complicated with perinatal hypoxic event].
Autorzy :
Xiao TT; Department of Neonatology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.
Yang L; Center of Molecular Medicine, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.
Wu BB; Center of Molecular Medicine, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.
Peng XM; Center of Molecular Medicine, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.
Wang HJ; Center of Molecular Medicine, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.
Cheng GQ; Department of Neonatology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.
Wang LS; Department of Neonatology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.
Cao Y; Department of Neonatology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.
Hu LY; Department of Neonatology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.
Zhou WH; Department of Neonatology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.
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Źródło :
Zhonghua er ke za zhi = Chinese journal of pediatrics [Zhonghua Er Ke Za Zhi] 2021 Apr 02; Vol. 59 (4), pp. 280-285.
Typ publikacji :
Journal Article
MeSH Terms :
Cesarean Section*
Hypoxia-Ischemia, Brain*/genetics
3-Hydroxysteroid Dehydrogenases ; Child ; Female ; Genotype ; Humans ; Hypoxia ; Infant, Newborn ; Male ; Nerve Tissue Proteins ; Phenotype ; Potassium Channels, Sodium-Activated ; Pregnancy ; Retrospective Studies
Czasopismo naukowe
Tytuł :
Hypoxic preconditioning - A nonpharmacological approach in COVID-19 prevention.
Autorzy :
Hertzog RG; Military Medical Research Center, Bucharest, Romania.
Bicheru NS; Military Medical Research Center, Bucharest, Romania. Electronic address: .
Popescu DM; Military Medical Research Center, Bucharest, Romania.
Călborean O; Military Medical Research Center, Bucharest, Romania.
Catrina AM; Military Medical Research Center, Bucharest, Romania.
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Źródło :
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [Int J Infect Dis] 2021 Feb; Vol. 103, pp. 415-419. Date of Electronic Publication: 2020 Nov 26.
Typ publikacji :
Journal Article
MeSH Terms :
Hypoxia*
COVID-19/*prevention & control
Animals ; Cell Survival ; Humans ; Hypoxia-Inducible Factor 1/metabolism ; Male ; Mesenchymal Stem Cells/metabolism ; SARS-CoV-2
Czasopismo naukowe
Tytuł :
The journey from erythropoietin to 2019 Nobel Prize: Focus on hypoxia-inducible factors in the kidney.
Autorzy :
Pan SY; Division of Nephrology, Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan; Renal Division, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Chiang WC; Renal Division, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Chen YM; Renal Division, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; Department of Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address: .
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Źródło :
Journal of the Formosan Medical Association = Taiwan yi zhi [J Formos Med Assoc] 2021 Jan; Vol. 120 (1 Pt 1), pp. 60-67. Date of Electronic Publication: 2020 Jun 17.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Hypoxia*
Nobel Prize*
Erythropoietin ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit ; Kidney ; Oxygen
Czasopismo naukowe
Tytuł :
Hypoxia Induces Transcriptional and Translational Downregulation of the Type I IFN Pathway in Multiple Cancer Cell Types.
Autorzy :
Miar A; Department of Medical Oncology, Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.
Arnaiz E; Department of Medical Oncology, Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.
Bridges E; Department of Medical Oncology, Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.
Beedie S; Department of Medical Oncology, Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.
Cribbs AP; Botnar Research Center, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, NIHR Oxford BRU, University of Oxford, United Kingdom.
Downes DJ; Medical Research Council (MRC) Molecular Hematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.
Beagrie RA; Medical Research Council (MRC) Molecular Hematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.
Rehwinkel J; Medical Research Council Human Immunology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Harris AL; Department of Medical Oncology, Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom. .
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Źródło :
Cancer research [Cancer Res] 2020 Dec 01; Vol. 80 (23), pp. 5245-5256. Date of Electronic Publication: 2020 Oct 28.
Typ publikacji :
Journal Article
MeSH Terms :
Tumor Hypoxia*
Interferon Type I/*metabolism
Neoplasms/*genetics
Neoplasms/*metabolism
Neoplasms/*pathology
Animals ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Down-Regulation ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Interferon Regulatory Factor-3/genetics ; Interferon Regulatory Factor-3/metabolism ; Interferon Type I/genetics ; Mice ; RNA, Messenger ; Signal Transduction/immunology ; Single-Cell Analysis ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Lessons from neuronal HIF1a: Understanding its role in ventilatory acclimatization to hypoxia.
Autorzy :
Khuu MA; Department of Physiology and Neurobiology, University of Connecticut, Storrs, CT, 06269, USA.
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Źródło :
The Journal of physiology [J Physiol] 2020 Nov; Vol. 598 (21), pp. 4751-4752. Date of Electronic Publication: 2020 Aug 05.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Hypoxia*
Solitary Nucleus*
Acclimatization ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit ; Neurons
Czasopismo naukowe
Tytuł :
Radiation Damage to Tumor Vasculature Initiates a Program That Promotes Tumor Recurrences.
Autorzy :
Brown JM; Department of Neurology, Stanford University School of Medicine, Stanford, California. Electronic address: .
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Źródło :
International journal of radiation oncology, biology, physics [Int J Radiat Oncol Biol Phys] 2020 Nov 01; Vol. 108 (3), pp. 734-744. Date of Electronic Publication: 2020 May 28.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Tumor Hypoxia*
Blood Vessels/*radiation effects
Hypoxia-Inducible Factor 1/*metabolism
Neoplasm Recurrence, Local/*etiology
Neoplasms/*blood supply
Neoplasms/*radiotherapy
Benzylamines/pharmacology ; Bone Marrow Cells ; Cell Polarity ; Chemokine CXCL12/metabolism ; Cyclams/pharmacology ; Endothelial Cells/radiation effects ; Humans ; Hypoxia-Inducible Factor 1/genetics ; Neoplasm Recurrence, Local/blood supply ; Neoplasms/metabolism ; Radiotherapy Dosage ; Reactive Oxygen Species/metabolism ; Receptors, CXCR4/antagonists & inhibitors ; Receptors, CXCR4/metabolism ; Tumor-Associated Macrophages/cytology ; Tumor-Associated Macrophages/metabolism ; Tumor-Associated Macrophages/radiation effects
Czasopismo naukowe
Tytuł :
rs1769793 variant reduces EGLN1 expression in skeletal muscle and hippocampus and contributes to high aerobic capacity in hypoxia.
Autorzy :
Liu G; Beijing Institute for Brain Disorders, Capital Medical University, Beijing 100069, China; .; Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.; National Engineering Laboratory of Internet Medical Diagnosis and Treatment Technology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
Zhao W; Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
Zhang H; Beijing Institute for Brain Disorders, Capital Medical University, Beijing 100069, China.; National Engineering Laboratory of Internet Medical Diagnosis and Treatment Technology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
Wang T; Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China.; Department of Bioinformatics, Chinese Institute for Brain Research, Beijing 102206, China.
Han Z; School of Medicine, Tsinghua University-Peking University Center for Life Sciences, Tsinghua University, Beijing 100084, China.; School of Pharmaceutical Sciences, Tsinghua University-Peking University Center for Life Sciences, Tsinghua University, Beijing 100084, China.; State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100005, China.; Department of Pathophysiology, Peking Union Medical College, Beijing 100021, China.
Ji X; Beijing Institute for Brain Disorders, Capital Medical University, Beijing 100069, China; .; Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.; National Engineering Laboratory of Internet Medical Diagnosis and Treatment Technology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.; Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.; Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing 100069, China.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Nov 24; Vol. 117 (47), pp. 29283-29285. Date of Electronic Publication: 2020 Oct 27.
Typ publikacji :
Letter; Comment
MeSH Terms :
Altitude*
Hypoxia*/genetics
Hippocampus ; Humans ; Hypoxia-Inducible Factor-Proline Dioxygenases ; Muscle, Skeletal ; Peru
Opinia redakcyjna
Tytuł :
CircCDK8 regulates osteogenic differentiation and apoptosis of PDLSCs by inducing ER stress/autophagy during hypoxia.
Autorzy :
Zheng J; Department of Endodontics, Key Laboratory of Oral Clinical Medicine, the Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Zhu X; Department of Endodontics, Stomatological Hospital, College of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.
He Y; Department of Endodontics, Stomatological Hospital, College of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.
Hou S; Stomatological Hospital of Chongqing Medical University, Chongqing, China.
Liu T; Department of Endodontics, Key Laboratory of Oral Clinical Medicine, the Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Zhi K; Department of Oral and Maxillofacial Surgery, Key Laboratory of Oral Clinical Medicine, the Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Hou T; Department of Endodontics, Stomatological Hospital, College of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.
Gao L; Department of Oral and Maxillofacial Surgery, Key Laboratory of Oral Clinical Medicine, the Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
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Źródło :
Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2021 Feb; Vol. 1485 (1), pp. 56-70. Date of Electronic Publication: 2020 Sep 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*physiology
Cyclin-Dependent Kinase 8/*genetics
Hypoxia/*genetics
Mesenchymal Stem Cells/*physiology
Osteogenesis/*physiology
Periodontal Ligament/*cytology
RNA, Circular/*genetics
Alkaline Phosphatase/genetics ; Alkaline Phosphatase/metabolism ; Apoptosis/drug effects ; Autophagy/drug effects ; Autophagy/physiology ; Cell Proliferation/drug effects ; Cell Proliferation/physiology ; Cobalt/pharmacology ; Collagen Type I/genetics ; Collagen Type I/metabolism ; Core Binding Factor Alpha 1 Subunit/genetics ; Core Binding Factor Alpha 1 Subunit/metabolism ; Cyclin-Dependent Kinase 8/metabolism ; Endoplasmic Reticulum Stress/drug effects ; Endoplasmic Reticulum Stress/physiology ; Humans ; Hypoxia/metabolism ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Mesenchymal Stem Cells/drug effects ; Osteocalcin/genetics ; Osteocalcin/metabolism ; Osteogenesis/drug effects ; Periodontal Ligament/drug effects ; Periodontitis/genetics ; Periodontitis/metabolism ; RNA, Circular/metabolism ; Signal Transduction/drug effects ; Signal Transduction/physiology
Czasopismo naukowe
Tytuł :
Intrapartum zigzag pattern of fetal heart rate is an early sign of fetal hypoxia: A large obstetric retrospective cohort study.
Autorzy :
Tarvonen M; Department of Obstetrics and Gynecology, University of Helsinki, and Helsinki University Hospital, Helsinki, Finland.
Hovi P; National Institute for Health and Welfare (THL), Helsinki, Finland.; Children's Hospital, Pediatric Research Center, University of Helsinki, and Helsinki University Hospital, Helsinki, Finland.
Sainio S; Finnish Red Cross Blood Transfusion Service, Helsinki, Finland.
Vuorela P; Health and Social Welfare Department, Vantaa, Finland.
Andersson S; Children's Hospital, Pediatric Research Center, University of Helsinki, and Helsinki University Hospital, Helsinki, Finland.
Teramo K; Department of Obstetrics and Gynecology, University of Helsinki, and Helsinki University Hospital, Helsinki, Finland.
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Źródło :
Acta obstetricia et gynecologica Scandinavica [Acta Obstet Gynecol Scand] 2021 Feb; Vol. 100 (2), pp. 252-262. Date of Electronic Publication: 2020 Oct 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Heart Rate, Fetal*
Fetal Hypoxia/*diagnosis
Acidosis/epidemiology ; Adult ; Apgar Score ; Bradycardia/diagnosis ; Bradycardia/epidemiology ; Cardiotocography ; Cohort Studies ; Female ; Fetal Blood/chemistry ; Fetal Diseases/diagnosis ; Fetal Diseases/epidemiology ; Fetal Hypoxia/epidemiology ; Finland/epidemiology ; Humans ; Hydrogen-Ion Concentration ; Hypoglycemia/epidemiology ; Hypoxia-Ischemia, Brain/epidemiology ; Infant, Newborn ; Intensive Care Units, Neonatal ; Intubation, Intratracheal ; Male ; Oxygen/blood ; Patient Admission ; Pregnancy ; Resuscitation ; Retrospective Studies ; Sensitivity and Specificity ; Tachycardia/diagnosis ; Tachycardia/epidemiology ; Umbilical Arteries/chemistry
Czasopismo naukowe
Tytuł :
Hypoxia and pancreatic ductal adenocarcinoma.
Autorzy :
Yamasaki A; Department of Cancer Therapy and Research, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Yanai K; Department of Cancer Therapy and Research, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Onishi H; Department of Cancer Therapy and Research, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2020 Aug 01; Vol. 484, pp. 9-15. Date of Electronic Publication: 2020 May 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Hypoxia*
Carcinoma, Pancreatic Ductal/*genetics
Gene Expression Regulation, Neoplastic/*genetics
Pancreatic Neoplasms/*genetics
Tumor Microenvironment/*genetics
Antineoplastic Agents/pharmacology ; Carcinoma, Pancreatic Ductal/metabolism ; Carcinoma, Pancreatic Ductal/therapy ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Immunotherapy/methods ; Pancreatic Neoplasms/metabolism ; Pancreatic Neoplasms/therapy ; Tumor Microenvironment/drug effects
Czasopismo naukowe
Tytuł :
HIF-1α downregulation of miR-433-3p in adipocyte-derived exosomes contributes to NPC progression via targeting SCD1.
Autorzy :
Yin H; Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, China.; Institute of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, China.
Qiu X; Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, China.; Institute of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, China.
Shan Y; Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, China.; Institute of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, China.
You B; Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, China.; Institute of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, China.
Xie L; Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, China.; Institute of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, China.
Zhang P; Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, China.; Institute of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, China.
Zhao J; Department of Paediatrics, Affiliated Hospital of Nantong University, Nantong, China.
You Y; Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, China.; Institute of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, China.
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Źródło :
Cancer science [Cancer Sci] 2021 Apr; Vol. 112 (4), pp. 1457-1470. Date of Electronic Publication: 2021 Feb 22.
Typ publikacji :
Journal Article
MeSH Terms :
Adipocytes/*pathology
Down-Regulation/*genetics
Exosomes/*genetics
Hypoxia-Inducible Factor 1, alpha Subunit/*genetics
MicroRNAs/*genetics
Nasopharyngeal Carcinoma/*genetics
Nasopharyngeal Neoplasms/*genetics
Stearoyl-CoA Desaturase/*genetics
Animals ; Cell Movement/genetics ; Cell Proliferation/genetics ; Gene Expression Regulation, Neoplastic/genetics ; Humans ; Hypoxia/genetics ; Hypoxia/pathology ; Lipid Metabolism/genetics ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Nasopharyngeal Carcinoma/pathology ; Nasopharyngeal Neoplasms/pathology ; Promoter Regions, Genetic/genetics
Czasopismo naukowe
Tytuł :
Hypoxia-reoxygenation stress modulates the hepatopancreas transcriptome of Chinese mitten crab Eriocheir sinensis.
Autorzy :
Xu Y; Freshwater Fisheries Research Institute of Jiangsu Province, Nanjing 210017, China.
Miao Z; Freshwater Fisheries Research Institute of Jiangsu Province, Nanjing 210017, China; College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
Li X; Freshwater Fisheries Research Institute of Jiangsu Province, Nanjing 210017, China.
Lin H; Freshwater Fisheries Research Institute of Jiangsu Province, Nanjing 210017, China.
Cheng Y; Freshwater Fisheries Research Institute of Jiangsu Province, Nanjing 210017, China.
Pan J; Freshwater Fisheries Research Institute of Jiangsu Province, Nanjing 210017, China; College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China. Electronic address: .
Xu Z; Freshwater Fisheries Research Institute of Jiangsu Province, Nanjing 210017, China; College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China. Electronic address: .
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Źródło :
Gene [Gene] 2021 Mar 01; Vol. 771, pp. 145361. Date of Electronic Publication: 2020 Dec 16.
Typ publikacji :
Journal Article
MeSH Terms :
Aryl Hydrocarbon Receptor Nuclear Translocator/*genetics
Brachyura/*genetics
Gene Expression Profiling/*veterinary
Hypoxia-Inducible Factor 1, alpha Subunit/*genetics
Animals ; Arthropod Proteins/genetics ; Cell Hypoxia ; Gene Expression Regulation ; Hepatopancreas/chemistry ; Sequence Analysis, RNA/veterinary ; Stress, Physiological
Czasopismo naukowe
Tytuł :
Regulatory Mechanism of MicroRNA-30b on Neonatal Hypoxic-Ischemic Encephalopathy (HIE).
Autorzy :
Wang W; Department of Pediatrics, Tianjin hospital, Tianjin 300211, China. Electronic address: .
Jia L; Department of Pediatrics, Tianjin hospital, Tianjin hospital of Tianjin University, Tianjin 300211, China. Electronic address: .
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Źródło :
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association [J Stroke Cerebrovasc Dis] 2021 Mar; Vol. 30 (3), pp. 105553. Date of Electronic Publication: 2020 Dec 24.
Typ publikacji :
Journal Article
MeSH Terms :
Brain/*blood supply
Endothelial Cells/*metabolism
Hypoxia-Ischemia, Brain/*blood
Infant, Newborn, Diseases/*blood
MicroRNAs/*blood
Biomarkers/blood ; Case-Control Studies ; Cell Hypoxia ; Cells, Cultured ; Female ; Gene Expression Regulation ; Humans ; Hypoxia-Ischemia, Brain/genetics ; Infant, Newborn ; Infant, Newborn, Diseases/genetics ; Male ; MicroRNAs/genetics ; P-Selectin/blood ; Plasminogen Activator Inhibitor 1/blood ; Plasminogen Activator Inhibitor 1/genetics
Czasopismo naukowe
Tytuł :
The HIF-1α antisense long non-coding RNA drives a positive feedback loop of HIF-1α mediated transactivation and glycolysis.
Autorzy :
Zheng F; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China.; Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China.
Chen J; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China.; Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China.
Zhang X; Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China.
Wang Z; State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, China.
Chen J; Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China.
Lin X; Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China.
Huang H; Chongqing Key Laboratory of Molecular Oncology and Epigenetics, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Fu W; Department of Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China.
Liang J; Department of Biochemistry and Biophysics, School of Basic Medical Sciences, Peking University Health Science Center, 38 Xueyuan Road, Beijing, 100191, China.
Wu W; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China.; Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China.
Li B; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China.
Yao H; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China.; Department of Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China.
Hu H; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China. .; Department of Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China. .
Song E; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China. .; Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China. .; Bioland Laboratory, Guangzhou, 510005, China. .; Fountain-Valley Institute for Life Sciences, 4th Floor, Building D, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Huangpu District, Guangzhou, 510535, China. .
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Źródło :
Nature communications [Nat Commun] 2021 Feb 26; Vol. 12 (1), pp. 1341. Date of Electronic Publication: 2021 Feb 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Glycolysis/*physiology
Hypoxia-Inducible Factor 1, alpha Subunit/*genetics
Hypoxia-Inducible Factor 1, alpha Subunit/*metabolism
RNA, Long Noncoding/*metabolism
Transcriptional Activation/*physiology
Animals ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Carrier Proteins/metabolism ; Feedback ; Female ; Gene Expression Regulation, Neoplastic ; Gene Knockdown Techniques ; Humans ; Hypoxia-Inducible Factor-Proline Dioxygenases/metabolism ; Membrane Proteins/metabolism ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Thyroid Hormones/metabolism
Czasopismo naukowe
Tytuł :
Hyaluronic Acid Conjugated Metformin-Phospholipid Sonocomplex: A Biphasic Complexation Approach to Correct Hypoxic Tumour Microenvironment.
Autorzy :
Farag MM; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Abd El Malak NS; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt.; School of Pharmacy, New Giza University, Giza, Egypt.
Yehia SA; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Ahmed MA; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt.; School of Pharmacy, New Giza University, Giza, Egypt.
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Źródło :
International journal of nanomedicine [Int J Nanomedicine] 2021 Feb 11; Vol. 16, pp. 1005-1019. Date of Electronic Publication: 2021 Feb 11 (Print Publication: 2021).
Typ publikacji :
Journal Article
MeSH Terms :
Sonication*
Hyaluronic Acid/*chemistry
Metformin/*pharmacology
Phospholipids/*chemistry
Tumor Hypoxia/*drug effects
Tumor Microenvironment/*drug effects
1-Octanol/chemistry ; Animals ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Glucose/pharmacology ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Inhibitory Concentration 50 ; Micelles ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Oxygen Consumption/drug effects ; Pancreatic Neoplasms/pathology ; Particle Size ; Proton Magnetic Resonance Spectroscopy ; Reactive Oxygen Species/metabolism ; Solubility ; Spectroscopy, Fourier Transform Infrared ; Static Electricity ; Water/chemistry
Czasopismo naukowe
Tytuł :
Normoxic Tumour Extracellular Vesicles Modulate the Response of Hypoxic Cancer and Stromal Cells to Doxorubicin In Vitro.
Autorzy :
Patras L; Department of Molecular Biology and Biotechnology, Center of Systems Biology, Biodiversity and Bioresources, Faculty of Biology and Geology, Babes-Bolyai University, 400006 Cluj-Napoca, Romania.; Molecular Biology Centre, Institute for Interdisciplinary Research in Bio-Nano-Sciences, Babes-Bolyai University, 400271 Cluj-Napoca, Romania.
Fens MHAM; Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.; Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, The Netherlands.
Vader P; Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
Barendrecht A; Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
Sesarman A; Department of Molecular Biology and Biotechnology, Center of Systems Biology, Biodiversity and Bioresources, Faculty of Biology and Geology, Babes-Bolyai University, 400006 Cluj-Napoca, Romania.; Molecular Biology Centre, Institute for Interdisciplinary Research in Bio-Nano-Sciences, Babes-Bolyai University, 400271 Cluj-Napoca, Romania.
Banciu M; Department of Molecular Biology and Biotechnology, Center of Systems Biology, Biodiversity and Bioresources, Faculty of Biology and Geology, Babes-Bolyai University, 400006 Cluj-Napoca, Romania.; Molecular Biology Centre, Institute for Interdisciplinary Research in Bio-Nano-Sciences, Babes-Bolyai University, 400271 Cluj-Napoca, Romania.
Schiffelers R; Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Aug 19; Vol. 21 (17). Date of Electronic Publication: 2020 Aug 19.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Resistance, Neoplasm*
Tumor Hypoxia*
Antibiotics, Antineoplastic/*toxicity
Colonic Neoplasms/*metabolism
Doxorubicin/*toxicity
Extracellular Vesicles/*metabolism
Animals ; Cell Line, Tumor ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Mice ; RAW 264.7 Cells ; Stromal Cells/drug effects ; Stromal Cells/metabolism ; bcl-X Protein/metabolism
Czasopismo naukowe
Tytuł :
Adaptive response of reproduction to high-altitude hypoxic stress by altering mRNA expression of hypoxia-inducible factors in female yaks ( Bos grunniens ).
Autorzy :
He XD; Key-Laboratory of Animal Science of State Ethnic Affairs Commission, Southwest Minzu University, Chengdu, Sichuan, China.
Xia Y; Key-Laboratory of Animal Science of State Ethnic Affairs Commission, Southwest Minzu University, Chengdu, Sichuan, China.
Jige MT; Key-Laboratory of Animal Science of State Ethnic Affairs Commission, Southwest Minzu University, Chengdu, Sichuan, China.
Wang H; Key-Laboratory of Animal Science of State Ethnic Affairs Commission, Southwest Minzu University, Chengdu, Sichuan, China.
Zi XD; Key-Laboratory of Animal Science of State Ethnic Affairs Commission, Southwest Minzu University, Chengdu, Sichuan, China.
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Źródło :
Animal biotechnology [Anim Biotechnol] 2020 Aug; Vol. 31 (4), pp. 373-375. Date of Electronic Publication: 2019 Apr 05.
Typ publikacji :
Journal Article
MeSH Terms :
Altitude*
Basic Helix-Loop-Helix Transcription Factors*/analysis
Basic Helix-Loop-Helix Transcription Factors*/genetics
Basic Helix-Loop-Helix Transcription Factors*/metabolism
Hypoxia-Inducible Factor 1, alpha Subunit*/analysis
Hypoxia-Inducible Factor 1, alpha Subunit*/genetics
Hypoxia-Inducible Factor 1, alpha Subunit*/metabolism
Adaptation, Physiological/*genetics
RNA, Messenger/*metabolism
Animals ; Cattle ; Female ; Hypoxia ; Organ Specificity ; Oviducts/chemistry ; Oviducts/metabolism ; Pituitary Gland/chemistry ; Pituitary Gland/metabolism ; RNA, Messenger/analysis ; RNA, Messenger/genetics ; Stress, Physiological/genetics
Czasopismo naukowe
Tytuł :
Hypoxia responsiveness linked variant in EGLN1 gene is enriched in oral cancer patients.
Autorzy :
Francis I; Department of Cell Biology and Molecular Genetics, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, India.
Arcot M; Department of Cell Biology and Molecular Genetics, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, India.
Mohiyuddin S M A; Department of Otorhinolaryngology, Sri Devaraj Urs Medical College, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, India.
Balakrishna S; Department of Cell Biology and Molecular Genetics, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, India. Electronic address: .
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Źródło :
Archives of oral biology [Arch Oral Biol] 2020 Aug; Vol. 116, pp. 104767. Date of Electronic Publication: 2020 May 19.
Typ publikacji :
Journal Article
MeSH Terms :
Genetic Predisposition to Disease*
Hypoxia-Inducible Factor-Proline Dioxygenases*/genetics
Mouth Neoplasms*/genetics
Case-Control Studies ; Gene Frequency ; Genotype ; Humans ; Hypoxia ; Polymorphism, Restriction Fragment Length ; Polymorphism, Single Nucleotide
Czasopismo naukowe

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