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Wyświetlanie 1-20 z 33
Podgląd okładki
Tytuł :
Photoenzymatic Reductions Enabled by Direct Excitation of Flavin-Dependent "Ene"-Reductases.
Autorzy :
Sandoval BA; Department of Chemistry, Princeton University, Princeton, New Jersey 08544 United States.
Clayman PD; Department of Chemistry, Princeton University, Princeton, New Jersey 08544 United States.
Oblinsky DG; Department of Chemistry, Princeton University, Princeton, New Jersey 08544 United States.
Oh S; Chemistry Division, Brookhaven National Laboratory, Upton, New York 11973-5000, United States.
Nakano Y; Department of Chemistry, Princeton University, Princeton, New Jersey 08544 United States.
Bird M; Chemistry Division, Brookhaven National Laboratory, Upton, New York 11973-5000, United States.
Scholes GD; Department of Chemistry, Princeton University, Princeton, New Jersey 08544 United States.
Hyster TK; Department of Chemistry, Princeton University, Princeton, New Jersey 08544 United States.
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Źródło :
Journal of the American Chemical Society [J Am Chem Soc] 2021 Feb 03; Vol. 143 (4), pp. 1735-1739. Date of Electronic Publication: 2020 Dec 31.
Typ publikacji :
Journal Article
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Quaternary Charge-Transfer Complex Enables Photoenzymatic Intermolecular Hydroalkylation of Olefins.
Autorzy :
Page CG; Department of Chemistry, Princeton University, Princeton, New Jersey 08544, United States.
Cooper SJ; Department of Chemistry, Princeton University, Princeton, New Jersey 08544, United States.
DeHovitz JS; Department of Chemistry, Princeton University, Princeton, New Jersey 08544, United States.
Oblinsky DG; Department of Chemistry, Princeton University, Princeton, New Jersey 08544, United States.
Biegasiewicz KF; Department of Chemistry, Princeton University, Princeton, New Jersey 08544, United States.
Antropow AH; Bristol Myers Squibb, 200 Cambridge Park Drive, Suite 3000, Cambridge, Massachusetts 02140, United States.
Armbrust KW; Bristol Myers Squibb, 200 Cambridge Park Drive, Suite 3000, Cambridge, Massachusetts 02140, United States.
Ellis JM; Bristol Myers Squibb, 200 Cambridge Park Drive, Suite 3000, Cambridge, Massachusetts 02140, United States.
Hamann LG; Takeda Pharmaceuticals, 30 Landsdowne Street, Cambridge, Massachusetts 02139, United States.
Horn EJ; Bristol Myers Squibb, 10300 Campus Point Drive, Suite 100, San Diego, California 92121, United States.
Oberg KM; Bristol Myers Squibb, 10300 Campus Point Drive, Suite 100, San Diego, California 92121, United States.
Scholes GD; Department of Chemistry, Princeton University, Princeton, New Jersey 08544, United States.
Hyster TK; Department of Chemistry, Princeton University, Princeton, New Jersey 08544, United States.
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Źródło :
Journal of the American Chemical Society [J Am Chem Soc] 2021 Jan 13; Vol. 143 (1), pp. 97-102. Date of Electronic Publication: 2020 Dec 28.
Typ publikacji :
Journal Article
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Active-Site Environmental Factors Customize the Photophysics of Photoenzymatic Old Yellow Enzymes.
Autorzy :
Kudisch B; Department of Chemistry, Princeton University, Princeton, New Jersey 08540, United States.
Oblinsky DG; Department of Chemistry, Princeton University, Princeton, New Jersey 08540, United States.
Black MJ; Department of Chemistry, Princeton University, Princeton, New Jersey 08540, United States.
Zieleniewska A; National Renewable Energy Laboratory, Golden, Colorado 80401, United States.
Emmanuel MA; Department of Chemistry, Princeton University, Princeton, New Jersey 08540, United States.
Rumbles G; National Renewable Energy Laboratory, Golden, Colorado 80401, United States.; Department of Chemistry and RASEI, University of Colorado Boulder, Colorado 80309, United States.
Hyster TK; Department of Chemistry, Princeton University, Princeton, New Jersey 08540, United States.
Scholes GD; Department of Chemistry, Princeton University, Princeton, New Jersey 08540, United States.
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Źródło :
The journal of physical chemistry. B [J Phys Chem B] 2020 Dec 10; Vol. 124 (49), pp. 11236-11249. Date of Electronic Publication: 2020 Nov 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Photoenzymatic Generation of Unstabilized Alkyl Radicals: An Asymmetric Reductive Cyclization.
Autorzy :
Clayman PD; Department of Chemistry, Princeton University, Princeton, New Jersey 08544, United States.
Hyster TK; Department of Chemistry, Princeton University, Princeton, New Jersey 08544, United States.
Pokaż więcej
Źródło :
Journal of the American Chemical Society [J Am Chem Soc] 2020 Sep 16; Vol. 142 (37), pp. 15673-15677. Date of Electronic Publication: 2020 Sep 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Static to inducibly dynamic stereocontrol: The convergent use of racemic β-substituted ketones.
Autorzy :
DeHovitz JS; Merck Center for Catalysis, Princeton University, Princeton, NJ 08544, USA.
Loh YY; Merck Center for Catalysis, Princeton University, Princeton, NJ 08544, USA.
Kautzky JA; Merck Center for Catalysis, Princeton University, Princeton, NJ 08544, USA.
Nagao K; Merck Center for Catalysis, Princeton University, Princeton, NJ 08544, USA.
Meichan AJ; Merck Center for Catalysis, Princeton University, Princeton, NJ 08544, USA.
Yamauchi M; Merck Center for Catalysis, Princeton University, Princeton, NJ 08544, USA.
MacMillan DWC; Merck Center for Catalysis, Princeton University, Princeton, NJ 08544, USA. .
Hyster TK; Merck Center for Catalysis, Princeton University, Princeton, NJ 08544, USA. .
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Źródło :
Science (New York, N.Y.) [Science] 2020 Aug 28; Vol. 369 (6507), pp. 1113-1118.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Czasopismo naukowe
Szczegóły Pełny tekst Pełny tekst
Podgląd okładki
Tytuł :
Photoenzymatic Hydrogenation of Heteroaromatic Olefins Using 'Ene'-Reductases with Photoredox Catalysts.
Autorzy :
Nakano Y; Department of Chemistry, Princeton University, Princeton, NJ, 08544, USA.; Present address: Monash Institute of Pharmaceutical Science, Monash University, Parkville, Victoria, 3052, Australia.
Black MJ; Department of Chemistry, Princeton University, Princeton, NJ, 08544, USA.
Meichan AJ; Department of Chemistry, Princeton University, Princeton, NJ, 08544, USA.
Sandoval BA; Department of Chemistry, Princeton University, Princeton, NJ, 08544, USA.
Chung MM; Department of Chemistry, Princeton University, Princeton, NJ, 08544, USA.
Biegasiewicz KF; Department of Chemistry, Princeton University, Princeton, NJ, 08544, USA.; Present address: School of Molecular Sciences, Arizona State University, Tempe, AZ, 85287, USA.
Zhu T; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.
Hyster TK; Department of Chemistry, Princeton University, Princeton, NJ, 08544, USA.
Pokaż więcej
Źródło :
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2020 Jun 22; Vol. 59 (26), pp. 10484-10488. Date of Electronic Publication: 2020 Apr 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Emerging strategies for expanding the toolbox of enzymes in biocatalysis.
Autorzy :
Sandoval BA; Department of Chemistry, Princeton University, Princeton, NJ, 08544, USA.
Hyster TK; Department of Chemistry, Princeton University, Princeton, NJ, 08544, USA. Electronic address: .
Pokaż więcej
Źródło :
Current opinion in chemical biology [Curr Opin Chem Biol] 2020 Apr; Vol. 55, pp. 45-51. Date of Electronic Publication: 2020 Jan 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Enzymes/*chemistry
Enzymes/*metabolism
Biocatalysis ; Computer Simulation ; Coordination Complexes/chemistry ; Enzyme Activation ; Metalloproteins/chemistry ; Metalloproteins/metabolism ; Metals/chemistry ; Oxidation-Reduction ; Protein Engineering ; Transition Elements/chemistry
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Asymmetric redox-neutral radical cyclization catalysed by flavin-dependent 'ene'-reductases.
Autorzy :
Black MJ; Department of Chemistry, Princeton University, Princeton, NJ, USA.
Biegasiewicz KF; Department of Chemistry, Princeton University, Princeton, NJ, USA.
Meichan AJ; Department of Chemistry, Princeton University, Princeton, NJ, USA.
Oblinsky DG; Department of Chemistry, Princeton University, Princeton, NJ, USA.
Kudisch B; Department of Chemistry, Princeton University, Princeton, NJ, USA.
Scholes GD; Department of Chemistry, Princeton University, Princeton, NJ, USA.
Hyster TK; Department of Chemistry, Princeton University, Princeton, NJ, USA. .
Pokaż więcej
Źródło :
Nature chemistry [Nat Chem] 2020 Jan; Vol. 12 (1), pp. 71-75. Date of Electronic Publication: 2019 Dec 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Flavin Mononucleotide/*chemistry
Free Radicals/*chemistry
Oxidoreductases/*chemistry
Oxindoles/*chemical synthesis
Amides/chemistry ; Biocatalysis ; Cyclization ; Oxidation-Reduction ; Stereoisomerism
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Photoenzymatic Catalysis Enables Radical-Mediated Ketone Reduction in Ene-Reductases.
Autorzy :
Sandoval BA; Department of Chemistry, Princeton University, Frick Chemical Laboratory, Princeton, NJ, 08544, USA.
Kurtoic SI; Department of Chemistry, Princeton University, Frick Chemical Laboratory, Princeton, NJ, 08544, USA.
Chung MM; Department of Chemistry, Princeton University, Frick Chemical Laboratory, Princeton, NJ, 08544, USA.
Biegasiewicz KF; Department of Chemistry, Princeton University, Frick Chemical Laboratory, Princeton, NJ, 08544, USA.
Hyster TK; Department of Chemistry, Princeton University, Frick Chemical Laboratory, Princeton, NJ, 08544, USA.
Pokaż więcej
Źródło :
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2019 Jun 24; Vol. 58 (26), pp. 8714-8718. Date of Electronic Publication: 2019 May 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Ketones/*chemistry
Oxidoreductases/*chemistry
Catalysis
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Photoexcitation of flavoenzymes enables a stereoselective radical cyclization.
Autorzy :
Biegasiewicz KF; Department of Chemistry, Princeton University, Princeton, NJ 08544, USA.
Cooper SJ; Department of Chemistry, Princeton University, Princeton, NJ 08544, USA.
Gao X; Department of Chemistry, Princeton University, Princeton, NJ 08544, USA.
Oblinsky DG; Department of Chemistry, Princeton University, Princeton, NJ 08544, USA.
Kim JH; Department of Chemistry, Princeton University, Princeton, NJ 08544, USA.
Garfinkle SE; Department of Chemistry, Princeton University, Princeton, NJ 08544, USA.
Joyce LA; Department of Process Research and Development, Merck, Rahway, NJ 07065, USA.
Sandoval BA; Department of Chemistry, Princeton University, Princeton, NJ 08544, USA.
Scholes GD; Department of Chemistry, Princeton University, Princeton, NJ 08544, USA.
Hyster TK; Department of Chemistry, Princeton University, Princeton, NJ 08544, USA. .
Pokaż więcej
Źródło :
Science (New York, N.Y.) [Science] 2019 Jun 21; Vol. 364 (6446), pp. 1166-1169.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Biocatalysis/*radiation effects
FMN Reductase/*chemistry
FMN Reductase/*radiation effects
Cyclization ; Enzyme Activation ; Lactams/chemical synthesis ; Light ; Stereoisomerism
Czasopismo naukowe
Szczegóły Pełny tekst Pełny tekst
Podgląd okładki
Tytuł :
Biocatalytic hydrogen atom transfer: an invigorating approach to free-radical reactions.
Autorzy :
Nakano Y; Department of Chemistry, Princeton University, Princeton, NJ 08544, USA.
Biegasiewicz KF; Department of Chemistry, Princeton University, Princeton, NJ 08544, USA.
Hyster TK; Department of Chemistry, Princeton University, Princeton, NJ 08544, USA. Electronic address: .
Pokaż więcej
Źródło :
Current opinion in chemical biology [Curr Opin Chem Biol] 2019 Apr; Vol. 49, pp. 16-24. Date of Electronic Publication: 2018 Sep 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Biocatalysis*
Free Radicals/*chemistry
Hydrogen/*chemistry
Hydrogen Bonding
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Correction: Ligand design for Rh(iii)-catalyzed C-H activation: an unsymmetrical cyclopentadienyl group enables a regioselective synthesis of dihydroisoquinolones.
Autorzy :
Hyster TK; Department of Chemistry , Colorado State University , Fort Collins , Colorado 80523 , USA . Email: .
Dalton DM; Department of Chemistry , Colorado State University , Fort Collins , Colorado 80523 , USA . Email: .
Rovis T; Department of Chemistry , Colorado State University , Fort Collins , Colorado 80523 , USA . Email: .; Department of Chemistry , Columbia University , 3000 Broadway , New York , NY 12007 , USA . Email: .
Pokaż więcej
Źródło :
Chemical science [Chem Sci] 2018 Oct 15; Vol. 9 (41), pp. 8024. Date of Electronic Publication: 2018 Oct 15 (Print Publication: 2018).
Typ publikacji :
Journal Article; Published Erratum
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Catalytic promiscuity enabled by photoredox catalysis in nicotinamide-dependent oxidoreductases.
Autorzy :
Biegasiewicz KF; Department of Chemistry, Princeton University, Princeton, NJ, USA.
Cooper SJ; Department of Chemistry, Princeton University, Princeton, NJ, USA.
Emmanuel MA; Department of Chemistry, Princeton University, Princeton, NJ, USA.
Miller DC; Department of Chemistry, Princeton University, Princeton, NJ, USA.
Hyster TK; Department of Chemistry, Princeton University, Princeton, NJ, USA. .
Pokaż więcej
Źródło :
Nature chemistry [Nat Chem] 2018 Jul; Vol. 10 (7), pp. 770-775. Date of Electronic Publication: 2018 Jun 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Biocatalysis*
Photochemical Processes*
Niacinamide/*metabolism
Oxidoreductases/*metabolism
Electron Transport ; Ketones/metabolism ; Models, Molecular ; Oxidoreductases/chemistry ; Protein Conformation ; Substrate Specificity
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Enantioselective Hydrogen Atom Transfer: Discovery of Catalytic Promiscuity in Flavin-Dependent 'Ene'-Reductases.
Autorzy :
Sandoval BA; Department of Chemistry, Princeton University , Princeton, New Jersey 08544, United States.
Meichan AJ; Department of Chemistry, Princeton University , Princeton, New Jersey 08544, United States.
Hyster TK; Department of Chemistry, Princeton University , Princeton, New Jersey 08544, United States.
Pokaż więcej
Źródło :
Journal of the American Chemical Society [J Am Chem Soc] 2017 Aug 23; Vol. 139 (33), pp. 11313-11316. Date of Electronic Publication: 2017 Aug 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Flavins/*metabolism
Gluconobacter oxydans/*enzymology
Hydrogen/*metabolism
Oxidoreductases/*metabolism
Electron Transport ; Esters/metabolism ; Flavin-Adenine Dinucleotide/analogs & derivatives ; Flavin-Adenine Dinucleotide/metabolism ; Gluconobacter oxydans/metabolism ; Halogenation ; Models, Molecular ; NADP/metabolism ; Oxidation-Reduction ; Stereoisomerism
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Correction: Ligand design for Rh(iii)-catalyzed C-H activation: an unsymmetrical cyclopentadienyl group enables a regioselective synthesis of dihydroisoquinolones.
Autorzy :
Hyster TK; Department of Chemistry , Colorado State University , Fort Collins , Colorado 80523 , USA . Email: .
Dalton DM; Department of Chemistry , Colorado State University , Fort Collins , Colorado 80523 , USA . Email: .
Rovis T; Department of Chemistry , Colorado State University , Fort Collins , Colorado 80523 , USA . Email: .; Department of Chemistry , Columbia University , 3000 Broadway , New York , NY 12007 , USA . Email: .
Pokaż więcej
Źródło :
Chemical science [Chem Sci] 2017 Feb 01; Vol. 8 (2), pp. 1666. Date of Electronic Publication: 2016 Dec 13.
Typ publikacji :
Journal Article; Published Erratum
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Accessing non-natural reactivity by irradiating nicotinamide-dependent enzymes with light.
Autorzy :
Emmanuel MA; Department of Chemistry, Princeton University, Princeton, New Jersey 08544, USA.
Greenberg NR; Department of Chemistry, Princeton University, Princeton, New Jersey 08544, USA.
Oblinsky DG; Department of Chemistry, Princeton University, Princeton, New Jersey 08544, USA.
Hyster TK; Department of Chemistry, Princeton University, Princeton, New Jersey 08544, USA.
Pokaż więcej
Źródło :
Nature [Nature] 2016 Dec 14; Vol. 540 (7633), pp. 414-417.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Light*
Alcohol Oxidoreductases/*metabolism
Alcohol Oxidoreductases/*radiation effects
Biocatalysis/*radiation effects
Coenzymes/*metabolism
Niacinamide/*metabolism
Coenzymes/chemistry ; Halogenation/radiation effects ; Hydrogen/metabolism ; Lactones/chemistry ; Lactones/metabolism ; NAD/metabolism ; NADP/metabolism ; Niacinamide/chemistry ; Oxidation-Reduction/radiation effects ; Photons ; Substrate Specificity
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Genetic Optimization of Metalloenzymes: Enhancing Enzymes for Non-Natural Reactions.
Autorzy :
Hyster TK; Department of Chemistry, Princeton University, Princeton, NJ, 08544, USA. .
Ward TR; Department of Chemistry, University of Basel, Spitalstrasse 51, CH-4056, Basel, Switzerland. .
Pokaż więcej
Źródło :
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2016 Jun 20; Vol. 55 (26), pp. 7344-57. Date of Electronic Publication: 2016 Mar 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Metalloproteins/*genetics
Protein Engineering
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Asymmetric Enzymatic Synthesis of Allylic Amines: A Sigmatropic Rearrangement Strategy.
Autorzy :
Prier CK; Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, MC 210-41, Pasadena, CA, 91125, USA.
Hyster TK; Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, MC 210-41, Pasadena, CA, 91125, USA.
Farwell CC; Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, MC 210-41, Pasadena, CA, 91125, USA.
Huang A; Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, MC 210-41, Pasadena, CA, 91125, USA.
Arnold FH; Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, MC 210-41, Pasadena, CA, 91125, USA. .
Pokaż więcej
Źródło :
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2016 Apr 04; Vol. 55 (15), pp. 4711-5. Date of Electronic Publication: 2016 Mar 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Amines/*chemical synthesis
Enzymes/*chemistry
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Enantioselective Enzyme-Catalyzed Aziridination Enabled by Active-Site Evolution of a Cytochrome P450.
Autorzy :
Farwell CC; Division of Chemistry and Chemical Engineering 210-41, California Institute of Technology , 1200 East California Boulevard, Pasadena, California 91125, United States.
Zhang RK; Division of Chemistry and Chemical Engineering 210-41, California Institute of Technology , 1200 East California Boulevard, Pasadena, California 91125, United States.
McIntosh JA; Division of Chemistry and Chemical Engineering 210-41, California Institute of Technology , 1200 East California Boulevard, Pasadena, California 91125, United States.
Hyster TK; Division of Chemistry and Chemical Engineering 210-41, California Institute of Technology , 1200 East California Boulevard, Pasadena, California 91125, United States.
Arnold FH; Division of Chemistry and Chemical Engineering 210-41, California Institute of Technology , 1200 East California Boulevard, Pasadena, California 91125, United States.
Pokaż więcej
Źródło :
ACS central science [ACS Cent Sci] 2015 May 27; Vol. 1 (2), pp. 89-93. Date of Electronic Publication: 2015 Apr 22.
Typ publikacji :
Journal Article
Czasopismo naukowe
Szczegóły
Wyświetlanie 1-20 z 33

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