A reverse vaccinology approach on transmembrane carbonic anhydrases from Plasmodium species as vaccine candidates for malaria prevention.
Autorzy:
Zolfaghari Emameh R; Department of Energy and Environmental Biotechnology, National Institute of Genetic Engineering and Biotechnology (NIGEB), 14965/161, Tehran, Iran. . Barker HR; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. Turpeinen H; Blueprint Genetics, Helsinki, Finland. Parkkila S; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Fimlab Laboratories Ltd and Tampere University Hospital, Tampere, Finland. HytönenVP; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Fimlab Laboratories Ltd and Tampere University Hospital, Tampere, Finland.
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Źródło:
Malaria journal [Malar J] 2022 Jun 15; Vol. 21 (1), pp. 189. Date of Electronic Publication: 2022 Jun 15.
The production and biochemical characterization of α-carbonic anhydrase from Lactobacillus rhamnosus GG.
Autorzy:
Urbański LJ; Faculty of Medicine and Health Technology, Tampere University, Arvo Ylpön katu 34, FI-33520, Tampere, Finland. . Bua S; Sezione Di Chimica Farmaceutica E Nutraceutica, Neurofarba Department, Università Degli Studi Di Firenze, Via U. Schiff 6, I-50019, Sesto Fiorentino (Florence), Italy. Angeli A; Sezione Di Chimica Farmaceutica E Nutraceutica, Neurofarba Department, Università Degli Studi Di Firenze, Via U. Schiff 6, I-50019, Sesto Fiorentino (Florence), Italy. Emameh RZ; Department of Energy and Environmental Biotechnology, National Institute of Genetic Engineering and Biotechnology (NIGEB), 14965/161, Tehran, Iran. Barker HR; Faculty of Medicine and Health Technology, Tampere University, Arvo Ylpön katu 34, FI-33520, Tampere, Finland. Kuuslahti M; Faculty of Medicine and Health Technology, Tampere University, Arvo Ylpön katu 34, FI-33520, Tampere, Finland. HytönenVP; Faculty of Medicine and Health Technology, Tampere University, Arvo Ylpön katu 34, FI-33520, Tampere, Finland.; Fimlab Ltd, Tampere University Hospital, Arvo Ylpön katu 4, FI-33520, Tampere, Finland. Parkkila S; Faculty of Medicine and Health Technology, Tampere University, Arvo Ylpön katu 34, FI-33520, Tampere, Finland.; Fimlab Ltd, Tampere University Hospital, Arvo Ylpön katu 4, FI-33520, Tampere, Finland. Supuran CT; Sezione Di Chimica Farmaceutica E Nutraceutica, Neurofarba Department, Università Degli Studi Di Firenze, Via U. Schiff 6, I-50019, Sesto Fiorentino (Florence), Italy.
Inhibition of the β-carbonic anhydrase from the protozoan pathogen Trichomonas vaginalis with sulphonamides.
Autorzy:
Urbański LJ; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. Angeli A; Neurofarba Department, Sezione di Chimica Farmaceutica e Nutraceutica, Università degli Studi di Firenze, Firenze, Italy. HytönenVP; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Fimlab Ltd, Tampere, Finland. Di Fiore A; Institute of Biostructures and Bioimaging of the National Research Council, Naples, Italy. De Simone G; Institute of Biostructures and Bioimaging of the National Research Council, Naples, Italy. Parkkila S; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Fimlab Ltd, Tampere, Finland. Supuran CT; Neurofarba Department, Sezione di Chimica Farmaceutica e Nutraceutica, Università degli Studi di Firenze, Firenze, Italy.
Activation of the β-carbonic anhydrase from the protozoan pathogen Trichomonas vaginalis with amines and amino acids.
Autorzy:
Angeli A; Neurofarba Department, Sezione di Chimica Farmaceutica e Nutraceutica, Università degli Studi di Firenze, Firenze, Italy. Urbański LJ; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. HytönenVP; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Fimlab Ltd, Tampere, Finland. Parkkila S; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Fimlab Ltd, Tampere, Finland. Supuran CT; Neurofarba Department, Sezione di Chimica Farmaceutica e Nutraceutica, Università degli Studi di Firenze, Firenze, Italy.
Structural and functional analysis of LIM domain-dependent recruitment of paxillin to αvβ3 integrin-positive focal adhesions.
Autorzy:
Ripamonti M; Department of Cell Physiology and Metabolism, University of Geneva, Centre Médical Universitaire, Geneva 4, Switzerland. Liaudet N; Bioimaging Core Facility, Faculty of Medicine, University of Geneva, Geneva 4, Switzerland. Azizi L; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. Bouvard D; Montpellier Cell Biology Research Center (CRBM), University of Montpellier, CNRS UMR 5237, Montpellier, France. HytönenVP; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Fimlab Laboratories, Tampere, Finland. Wehrle-Haller B; Department of Cell Physiology and Metabolism, University of Geneva, Centre Médical Universitaire, Geneva 4, Switzerland. .
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Źródło:
Communications biology [Commun Biol] 2021 Mar 29; Vol. 4 (1), pp. 380. Date of Electronic Publication: 2021 Mar 29.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Video-Audio Media
Modular vaccine platform based on the norovirus-like particle.
Autorzy:
Lampinen V; Faculty of Medicine and Health Technology, Tampere University, 33014, Tampere, Finland. Heinimäki S; Vaccine Development and Immunology/Vaccine Research Center, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. Laitinen OH; Faculty of Medicine and Health Technology, Tampere University, 33014, Tampere, Finland. Pesu M; Faculty of Medicine and Health Technology, Tampere University, 33014, Tampere, Finland.; Fimlab Laboratories, Tampere, Finland. Hankaniemi MM; Faculty of Medicine and Health Technology, Tampere University, 33014, Tampere, Finland. . Blazevic V; Vaccine Development and Immunology/Vaccine Research Center, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. . HytönenVP; Faculty of Medicine and Health Technology, Tampere University, 33014, Tampere, Finland. .; Fimlab Laboratories, Tampere, Finland. .
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Źródło:
Journal of nanobiotechnology [J Nanobiotechnology] 2021 Jan 19; Vol. 19 (1), pp. 25. Date of Electronic Publication: 2021 Jan 19.
Cancer associated talin point mutations disorganise cell adhesion and migration.
Autorzy:
Azizi L; BioMediTech, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. Cowell AR; School of Biosciences, University of Kent, Canterbury, CT2 7NJ, Kent, UK. Mykuliak VV; BioMediTech, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. Goult BT; School of Biosciences, University of Kent, Canterbury, CT2 7NJ, Kent, UK. . Turkki P; BioMediTech, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. .; Fimlab Laboratories, Tampere, Finland. . HytönenVP; BioMediTech, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. .; Fimlab Laboratories, Tampere, Finland. .
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Źródło:
Scientific reports [Sci Rep] 2021 Jan 11; Vol. 11 (1), pp. 347. Date of Electronic Publication: 2021 Jan 11.
Biochemical and structural characterisation of a protozoan beta-carbonic anhydrase from Trichomonas vaginalis .
Autorzy:
Urbański LJ; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. Di Fiore A; Institute of Biostructures and Bioimaging of the National Research Council, Naples, Italy. Azizi L; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. HytönenVP; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Fimlab Ltd, Tampere, Finland. Kuuslahti M; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. Buonanno M; Institute of Biostructures and Bioimaging of the National Research Council, Naples, Italy. Monti SM; Institute of Biostructures and Bioimaging of the National Research Council, Naples, Italy. Angeli A; Neurofarba Department, Sezione di Chimica Farmaceutica e Nutraceutica, Università degli Studi di Firenze, Sesto Fiorentino, Italy. Zolfaghari Emameh R; Department of Energy and Environmental Biotechnology, National Institute of Genetic Engineering and Biotechnology, (NIGEB), Tehran, Iran. Supuran CT; Neurofarba Department, Sezione di Chimica Farmaceutica e Nutraceutica, Università degli Studi di Firenze, Sesto Fiorentino, Italy. De Simone G; Institute of Biostructures and Bioimaging of the National Research Council, Naples, Italy. Parkkila S; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Fimlab Ltd, Tampere, Finland.
Sulphonamide inhibition profile of Staphylococcus aureus β-carbonic anhydrase.
Autorzy:
Urbanski LJ; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. Bua S; Neurofarba Department, Sezione di Chimica Farmaceutica e Nutraceutica, Università degli Studi di Firenze, Sesto Fiorentino (Firenze), Italy. Angeli A; Neurofarba Department, Sezione di Chimica Farmaceutica e Nutraceutica, Università degli Studi di Firenze, Sesto Fiorentino (Firenze), Italy. Kuuslahti M; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. HytönenVP; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Fimlab Ltd, Tampere University Hospital, Tampere, Finland. Supuran CT; Neurofarba Department, Sezione di Chimica Farmaceutica e Nutraceutica, Università degli Studi di Firenze, Sesto Fiorentino (Firenze), Italy. Parkkila S; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Fimlab Ltd, Tampere University Hospital, Tampere, Finland.
Antibody Responses against Enterovirus Proteases are Potential Markers for an Acute Infection.
Autorzy:
Saarinen NVV; Faculty of Medicine and Health Technology, Tampere University, FI-33014 Tampere, Finland. Stone VM; Faculty of Medicine and Health Technology, Tampere University, FI-33014 Tampere, Finland.; Karolinska Institutet, The Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska University Hospital, 14152 Stockholm, Sweden. Hankaniemi MM; Faculty of Medicine and Health Technology, Tampere University, FI-33014 Tampere, Finland. Mazur MA; Karolinska Institutet, The Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska University Hospital, 14152 Stockholm, Sweden. Vuorinen T; Turku University Hospital, Clinical Microbiology and University of Turku, Institute of Biomedicine, 20520 Turku, Finland. Flodström-Tullberg M; Faculty of Medicine and Health Technology, Tampere University, FI-33014 Tampere, Finland.; Karolinska Institutet, The Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska University Hospital, 14152 Stockholm, Sweden. Hyöty H; Faculty of Medicine and Health Technology, Tampere University, FI-33014 Tampere, Finland. HytönenVP; Faculty of Medicine and Health Technology, Tampere University, FI-33014 Tampere, Finland. Laitinen OH; Faculty of Medicine and Health Technology, Tampere University, FI-33014 Tampere, Finland.
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Źródło:
Viruses [Viruses] 2020 Jan 09; Vol. 12 (1). Date of Electronic Publication: 2020 Jan 09.
Host Cell Calpains Can Cleave Structural Proteins from the Enterovirus Polyprotein.
Autorzy:
Laajala M; Department of Biological and Environmental Science/Nanoscience center, University of Jyväskylä, Survontie 9C, FI-40500 Jyväskylä, Finland. Hankaniemi MM; Faculty of Medicine and Health Technology, Tampere University, FI-33014 Tampere, Finland. Määttä JAE; Faculty of Medicine and Health Technology, Tampere University, FI-33014 Tampere, Finland. HytönenVP; Faculty of Medicine and Health Technology, Tampere University, FI-33014 Tampere, Finland.; Department of Clinical Chemistry, Fimlab Laboratories, Pirkanmaa Hospital District, FI-33520 Tampere, Finland. Laitinen OH; Faculty of Medicine and Health Technology, Tampere University, FI-33014 Tampere, Finland. Marjomäki V; Department of Biological and Environmental Science/Nanoscience center, University of Jyväskylä, Survontie 9C, FI-40500 Jyväskylä, Finland.
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Źródło:
Viruses [Viruses] 2019 Nov 28; Vol. 11 (12). Date of Electronic Publication: 2019 Nov 28.
Design of modular gellan gum hydrogel functionalized with avidin and biotinylated adhesive ligands for cell culture applications.
Autorzy:
Gering C; Faculty of Medicine and Health Technology, BioMediTech, Tampere University, Tampere, Finland. Koivisto JT; Faculty of Medicine and Health Technology, BioMediTech, Tampere University, Tampere, Finland. Parraga J; Faculty of Medicine and Health Technology, BioMediTech, Tampere University, Tampere, Finland. Leppiniemi J; Faculty of Medicine and Health Technology, BioMediTech, Tampere University, Tampere, Finland. Vuornos K; Faculty of Medicine and Health Technology, BioMediTech, Tampere University, Tampere, Finland.; Research, Development and Innovation Center, Tampere University Hospital, Tampere, Finland. HytönenVP; Faculty of Medicine and Health Technology, BioMediTech, Tampere University, Tampere, Finland.; Fimlab Laboratories, Tampere, Finland. Miettinen S; Faculty of Medicine and Health Technology, BioMediTech, Tampere University, Tampere, Finland.; Research, Development and Innovation Center, Tampere University Hospital, Tampere, Finland. Kellomäki M; Faculty of Medicine and Health Technology, BioMediTech, Tampere University, Tampere, Finland.
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Źródło:
PloS one [PLoS One] 2019 Aug 30; Vol. 14 (8), pp. e0221931. Date of Electronic Publication: 2019 Aug 30 (Print Publication: 2019).
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