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Tytuł :
A Non-Toxic Concentration of Telomerase Inhibitor BIBR1532 Fails to Reduce TERT Expression in a Feeder-Free Induced Pluripotent Stem Cell Model of Human Motor Neurogenesis.
Autorzy :
Pandya VA; Department of Neuromuscular Diseases, University College London Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK.; The Francis Crick Institute, London NW1 1AT, UK.
Crerar H; Department of Neuromuscular Diseases, University College London Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK.; The Francis Crick Institute, London NW1 1AT, UK.
Mitchell JS; Department of Neuromuscular Diseases, University College London Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK.; The Francis Crick Institute, London NW1 1AT, UK.
Patani R; Department of Neuromuscular Diseases, University College London Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK.; The Francis Crick Institute, London NW1 1AT, UK.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 23; Vol. 22 (6). Date of Electronic Publication: 2021 Mar 23.
Typ publikacji :
Journal Article
MeSH Terms :
Aminobenzoates/*pharmacology
Enzyme Inhibitors/*pharmacology
Induced Pluripotent Stem Cells/*cytology
Induced Pluripotent Stem Cells/*drug effects
Motor Neurons/*cytology
Naphthalenes/*pharmacology
Neurogenesis/*drug effects
Telomerase/*antagonists & inhibitors
Telomerase/*genetics
Cell Differentiation/drug effects ; Cell Line ; Gene Expression Regulation/drug effects ; Humans ; Induced Pluripotent Stem Cells/metabolism ; Motor Neurons/metabolism
Czasopismo naukowe
Tytuł :
Clinical Trial in a Dish: Using Patient-Derived Induced Pluripotent Stem Cells to Identify Risks of Drug-Induced Cardiotoxicity.
Autorzy :
Lam CK; Stanford Cardiovascular Institute (C.K.L., J.C.W.), Stanford University School of Medicine, CA.; Department of Medicine, Division of Cardiovascular Medicine (C.K.L., J.C.W.), Stanford University School of Medicine, CA.; Department of Biological Sciences, University of Delaware, Newark (C.K.L.).
Wu JC; Stanford Cardiovascular Institute (C.K.L., J.C.W.), Stanford University School of Medicine, CA.; Department of Medicine, Division of Cardiovascular Medicine (C.K.L., J.C.W.), Stanford University School of Medicine, CA.; Department of Radiology (J.C.W.), Stanford University School of Medicine, CA.
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Źródło :
Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2021 Mar; Vol. 41 (3), pp. 1019-1031. Date of Electronic Publication: 2021 Jan 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Cardiotoxicity/*etiology
Cardiotoxins/*toxicity
Induced Pluripotent Stem Cells/*drug effects
Arrhythmias, Cardiac/chemically induced ; Drug Evaluation, Preclinical/methods ; Genetic Markers ; Humans ; Induced Pluripotent Stem Cells/pathology ; Induced Pluripotent Stem Cells/physiology ; Myocardial Contraction/drug effects ; Myocarditis/chemically induced ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/pathology ; Myocytes, Cardiac/physiology ; Pharmacogenomic Testing/methods ; Polymorphism, Single Nucleotide ; Precision Medicine/methods ; Risk Factors
Czasopismo naukowe
Tytuł :
Hydroxypropyl Cyclodextrin Improves Amiodarone-induced Aberrant Lipid Homeostasis of Alveolar Cells.
Autorzy :
Kanagaki S; Department of Drug Discovery for Lung Diseases and.; Watarase Research Center, Kyorin Pharmaceutical Co. Ltd., Shimotsuga-gun, Tochigi, Japan.
Suezawa T; Department of Drug Discovery for Lung Diseases and.; Watarase Research Center, Kyorin Pharmaceutical Co. Ltd., Shimotsuga-gun, Tochigi, Japan.
Moriguchi K; Department of Drug Discovery for Lung Diseases and.; Watarase Research Center, Kyorin Pharmaceutical Co. Ltd., Shimotsuga-gun, Tochigi, Japan.
Nakao K; Watarase Research Center, Kyorin Pharmaceutical Co. Ltd., Shimotsuga-gun, Tochigi, Japan.
Toyomoto M; Department of Drug Discovery for Lung Diseases and.; Department of Anatomy and Developmental Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan; and.
Yamamoto Y; Department of Drug Discovery for Lung Diseases and.
Murakami K; Watarase Research Center, Kyorin Pharmaceutical Co. Ltd., Shimotsuga-gun, Tochigi, Japan.
Hagiwara M; Department of Anatomy and Developmental Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan; and.
Gotoh S; Department of Drug Discovery for Lung Diseases and.
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Źródło :
American journal of respiratory cell and molecular biology [Am J Respir Cell Mol Biol] 2021 Apr; Vol. 64 (4), pp. 504-514.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
2-Hydroxypropyl-beta-cyclodextrin/*pharmacology
Alveolar Epithelial Cells/*drug effects
Amiodarone/*toxicity
Induced Pluripotent Stem Cells/*drug effects
Lipid Metabolism/*drug effects
A549 Cells ; Alveolar Epithelial Cells/metabolism ; Alveolar Epithelial Cells/pathology ; High-Throughput Screening Assays ; Homeostasis ; Humans ; Induced Pluripotent Stem Cells/metabolism ; Induced Pluripotent Stem Cells/pathology ; Protein Precursors/metabolism ; Pulmonary Surfactant-Associated Protein C/metabolism ; Pulmonary Surfactant-Associated Protein D/metabolism ; Pulmonary Surfactant-Associated Proteins/metabolism
Czasopismo naukowe
Tytuł :
Targeted addition of mini-dystrophin into rDNA locus of Duchenne muscular dystrophy patient-derived iPSCs.
Autorzy :
Zeng B; Center for Medical Genetics, School of Life Sciences, Central South University, Changsha 410078, China.
Zhou M; Center for Medical Genetics, School of Life Sciences, Central South University, Changsha 410078, China.
Liu B; Center for Medical Genetics, School of Life Sciences, Central South University, Changsha 410078, China.
Shen F; Center for Medical Genetics, School of Life Sciences, Central South University, Changsha 410078, China.
Xiao R; Center for Medical Genetics, School of Life Sciences, Central South University, Changsha 410078, China.
Su J; Center for Medical Genetics, School of Life Sciences, Central South University, Changsha 410078, China.
Hu Z; Center for Medical Genetics, School of Life Sciences, Central South University, Changsha 410078, China.
Zhang Y; Center for Medical Genetics, School of Life Sciences, Central South University, Changsha 410078, China.
Gu A; Center for Medical Genetics, School of Life Sciences, Central South University, Changsha 410078, China.
Wu L; Center for Medical Genetics, School of Life Sciences, Central South University, Changsha 410078, China; Hunan Jiahui Genetics Hospital, Changsha, Hunan 410078, China.
Liu X; Center for Medical Genetics, School of Life Sciences, Central South University, Changsha 410078, China. Electronic address: .
Liang D; Center for Medical Genetics, School of Life Sciences, Central South University, Changsha 410078, China; Hunan Jiahui Genetics Hospital, Changsha, Hunan 410078, China. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Mar 19; Vol. 545, pp. 40-45. Date of Electronic Publication: 2021 Feb 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA, Ribosomal/*genetics
Dystrophin/*genetics
Genetic Therapy/*methods
Induced Pluripotent Stem Cells/*metabolism
Muscular Dystrophy, Duchenne/*genetics
Muscular Dystrophy, Duchenne/*therapy
Cell Differentiation ; Cell Line ; Cellular Reprogramming Techniques ; Dystrophin/metabolism ; Exons ; Gene Expression ; Gene Targeting/methods ; Humans ; Induced Pluripotent Stem Cells/cytology ; Loss of Function Mutation ; Male ; Muscular Dystrophy, Duchenne/urine ; Myocytes, Cardiac/cytology ; Myocytes, Cardiac/metabolism ; Proof of Concept Study ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Sequence Deletion ; Urine/cytology
Czasopismo naukowe
Tytuł :
iPSC-Cardiomyocyte Models of Brugada Syndrome-Achievements, Challenges and Future Perspectives.
Autorzy :
Nijak A; Center of Medical Genetics, Faculty of Medicine and Health Sciences, University of Antwerp and Antwerp University Hospital, 2650 Antwerp, Belgium.
Saenen J; Department of Cardiology, Faculty of Medicine and Health Sciences, University of Antwerp and Antwerp University Hospital, 2610 Antwerp, Belgium.
Labro AJ; Department of Biomedical Sciences, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, 2610 Antwerp, Belgium.; Department of Basic and Applied Medical Sciences, Faculty of Medicine and Health Sciences, Ghent University, 9000 Ghent, Belgium.
Schepers D; Center of Medical Genetics, Faculty of Medicine and Health Sciences, University of Antwerp and Antwerp University Hospital, 2650 Antwerp, Belgium.; Department of Biomedical Sciences, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, 2610 Antwerp, Belgium.
Loeys BL; Center of Medical Genetics, Faculty of Medicine and Health Sciences, University of Antwerp and Antwerp University Hospital, 2650 Antwerp, Belgium.; Department of Human Genetics, Radboud University Medical Center, 6525 Nijmegen, The Netherlands.
Alaerts M; Center of Medical Genetics, Faculty of Medicine and Health Sciences, University of Antwerp and Antwerp University Hospital, 2650 Antwerp, Belgium.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 10; Vol. 22 (6). Date of Electronic Publication: 2021 Mar 10.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Models, Cardiovascular*
Brugada Syndrome/*metabolism
Induced Pluripotent Stem Cells/*metabolism
Myocytes, Cardiac/*metabolism
Brugada Syndrome/pathology ; Humans ; Induced Pluripotent Stem Cells/pathology ; Myocytes, Cardiac/pathology
Czasopismo naukowe
Tytuł :
Advancing Drug Discovery for Neurological Disorders Using iPSC-Derived Neural Organoids.
Autorzy :
Costamagna G; Dino Ferrari Centre, Department of Pathophysiology and Transplantation (DEPT), Neuroscience Section, University of Milan, 20122 Milan, Italy.; IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, Neurology Unit, Via Francesco Sforza 35, 20122 Milan, Italy.
Comi GP; Dino Ferrari Centre, Department of Pathophysiology and Transplantation (DEPT), Neuroscience Section, University of Milan, 20122 Milan, Italy.; IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, Neurology Unit, Via Francesco Sforza 35, 20122 Milan, Italy.
Corti S; Dino Ferrari Centre, Department of Pathophysiology and Transplantation (DEPT), Neuroscience Section, University of Milan, 20122 Milan, Italy.; IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, Neurology Unit, Via Francesco Sforza 35, 20122 Milan, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 06; Vol. 22 (5). Date of Electronic Publication: 2021 Mar 06.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Drug Discovery/*methods
Induced Pluripotent Stem Cells/*drug effects
Nervous System Diseases/*drug therapy
Organoids/*drug effects
Animals ; Automation ; Brain/cytology ; CRISPR-Cas Systems ; Cell Culture Techniques ; Collagen ; Drug Combinations ; Drug Evaluation, Preclinical/methods ; Drug Industry/organization & administration ; Forecasting ; High-Throughput Screening Assays ; Humans ; Induced Pluripotent Stem Cells/cytology ; Laminin ; Machine Learning ; Microscopy/methods ; Nervous System Diseases/pathology ; Proteoglycans ; RNA-Seq ; Reproducibility of Results ; Single-Cell Analysis
Czasopismo naukowe
Tytuł :
Effects of DLX3 on the osteogenic differentiation of induced pluripotent stem cell‑derived mesenchymal stem cells.
Autorzy :
Li J; The Medical Center of Stomatology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630, P.R. China.
Lin Q; The Medical Center of Stomatology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630, P.R. China.
Lin Y; The Medical Center of Stomatology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630, P.R. China.
Lai R; The Medical Center of Stomatology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630, P.R. China.
Zhang W; Department of Endodontics, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat‑sen University, Guangzhou, Guangdong 510055, P.R. China.
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Źródło :
Molecular medicine reports [Mol Med Rep] 2021 Apr; Vol. 23 (4). Date of Electronic Publication: 2021 Jan 26.
Typ publikacji :
Journal Article
MeSH Terms :
Bone Development/*genetics
Cell Differentiation/*genetics
Homeodomain Proteins/*genetics
Induced Pluripotent Stem Cells/*cytology
Osteogenesis/*genetics
Transcription Factors/*genetics
Adipogenesis/genetics ; Alkaline Phosphatase/genetics ; Bone Regeneration/genetics ; Calcification, Physiologic/genetics ; Cell Proliferation/genetics ; Chondrogenesis/genetics ; Gene Expression Regulation, Developmental/genetics ; Humans ; Induced Pluripotent Stem Cells/metabolism ; Mesenchymal Stem Cells/cytology ; Mesenchymal Stem Cells/metabolism
Czasopismo naukowe
Tytuł :
Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome.
Autorzy :
Inak G; Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany.; Department of General Pediatrics, Neonatology and Pediatric Cardiology, Duesseldorf University Hospital, Medical Faculty, Heinrich Heine University, Duesseldorf, Germany.
Rybak-Wolf A; Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrück Center for Molecular Medicine (MDC), Hannoversche Str 28, 10115, Berlin, Germany.
Lisowski P; Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany.; Department of General Pediatrics, Neonatology and Pediatric Cardiology, Duesseldorf University Hospital, Medical Faculty, Heinrich Heine University, Duesseldorf, Germany.; Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, Jastrzebiec, n/Warsaw, Magdalenka, Poland.
Pentimalli TM; Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrück Center for Molecular Medicine (MDC), Hannoversche Str 28, 10115, Berlin, Germany.
Jüttner R; Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany.
Glažar P; Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrück Center for Molecular Medicine (MDC), Hannoversche Str 28, 10115, Berlin, Germany.
Uppal K; Emory University, Atlanta, GA, USA.
Bottani E; Department of Diagnostics and Public Health, University of Verona, Verona, Italy.
Brunetti D; Mitochondrial Medicine Laboratory, Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy.; Unit of Medical Genetics and Neurogenetics Fondazione IRCCS Istituto Neurologico 'Carlo Besta', Milan, Italy.
Secker C; Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany.; Charité - Universitätsmedizin Berlin, Department of Neurology, Berlin, Germany.
Zink A; Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany.; Department of General Pediatrics, Neonatology and Pediatric Cardiology, Duesseldorf University Hospital, Medical Faculty, Heinrich Heine University, Duesseldorf, Germany.; Charité - Universitätsmedizin Berlin, Department of Neuropsychiatry, Berlin, Germany.
Meierhofer D; Max Planck Institute for Molecular Genetics, Berlin, Germany.
Henke MT; Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany.; Charité - Universitätsmedizin Berlin, Department of Neuropediatrics, Berlin, Germany.
Dey M; Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany.
Ciptasari U; Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany.
Mlody B; Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany.
Hahn T; Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany.
Berruezo-Llacuna M; Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany.
Karaiskos N; Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrück Center for Molecular Medicine (MDC), Hannoversche Str 28, 10115, Berlin, Germany.
Di Virgilio M; Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany.
Mayr JA; University Children's Hospital, Paracelsus Medical University (PMU), Salzburg, Austria.
Wortmann SB; University Children's Hospital, Paracelsus Medical University (PMU), Salzburg, Austria.; Radboud Center for Mitochondrial Medicine, Department of Pediatrics, Amalia Children's Hospital, Radboudumc, Nijmegen, The Netherlands.
Priller J; Charité - Universitätsmedizin Berlin, Department of Neuropsychiatry, Berlin, Germany.; University of Edinburgh and UK DRI, Edinburgh, UK.; Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technical University Munich, Munich, Germany.
Gotthardt M; Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany.
Jones DP; Emory University, Atlanta, GA, USA.
Mayatepek E; Department of General Pediatrics, Neonatology and Pediatric Cardiology, Duesseldorf University Hospital, Medical Faculty, Heinrich Heine University, Duesseldorf, Germany.
Stenzel W; Charité - Universitätsmedizin, Department of Neuropathology, Berlin, Germany.
Diecke S; Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany.; Berlin Institute of Health (BIH), Berlin, Germany.
Kühn R; Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany.
Wanker EE; Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany.
Rajewsky N; Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrück Center for Molecular Medicine (MDC), Hannoversche Str 28, 10115, Berlin, Germany. .
Schuelke M; Charité - Universitätsmedizin Berlin, Department of Neuropediatrics, Berlin, Germany. .; NeuroCure Clinical Research Center, Berlin, Germany. .
Prigione A; Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany. .; Department of General Pediatrics, Neonatology and Pediatric Cardiology, Duesseldorf University Hospital, Medical Faculty, Heinrich Heine University, Duesseldorf, Germany. .
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Źródło :
Nature communications [Nat Commun] 2021 Mar 26; Vol. 12 (1), pp. 1929. Date of Electronic Publication: 2021 Mar 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutation*
Induced Pluripotent Stem Cells/*metabolism
Leigh Disease/*genetics
Membrane Proteins/*genetics
Mitochondrial Proteins/*genetics
Neurons/*metabolism
Organoids/*metabolism
Cells, Cultured ; Child, Preschool ; Humans ; Induced Pluripotent Stem Cells/cytology ; Leigh Disease/metabolism ; Male ; Metabolomics/methods ; Mitochondria/genetics ; Mitochondria/metabolism ; Morphogenesis/genetics ; Neurons/cytology ; Proteomics/methods ; Single-Cell Analysis/methods ; Whole Exome Sequencing
Czasopismo naukowe
Tytuł :
Reply to 'Are atrial human pluripotent stem cell-derived cardiomyocytes ready to identify drugs that beat atrial fibrillation?'
Autorzy :
Shiti A; Sohnis Research Laboratory for Cardiac Electrophysiology and Regenerative Medicine, the Rappaport Faculty of Medicine and Research Institute, Technion‒Israel Institute of Technology, Haifa, Israel.
Goldfracht I; Sohnis Research Laboratory for Cardiac Electrophysiology and Regenerative Medicine, the Rappaport Faculty of Medicine and Research Institute, Technion‒Israel Institute of Technology, Haifa, Israel.
Shaheen N; Sohnis Research Laboratory for Cardiac Electrophysiology and Regenerative Medicine, the Rappaport Faculty of Medicine and Research Institute, Technion‒Israel Institute of Technology, Haifa, Israel.
Protze S; McEwen Center for Regenerative Medicine, University Health Network, Toronto, ON, Canada.
Gepstein L; Sohnis Research Laboratory for Cardiac Electrophysiology and Regenerative Medicine, the Rappaport Faculty of Medicine and Research Institute, Technion‒Israel Institute of Technology, Haifa, Israel. .; Cardiology Department, Rambam Health Care Campus, Haifa, Israel. .
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Źródło :
Nature communications [Nat Commun] 2021 Mar 19; Vol. 12 (1), pp. 1729. Date of Electronic Publication: 2021 Mar 19.
Typ publikacji :
Letter; Research Support, Non-U.S. Gov't; Comment
MeSH Terms :
Atrial Fibrillation*/drug therapy
Induced Pluripotent Stem Cells*
Pharmaceutical Preparations*
Heart Atria ; Humans ; Myocytes, Cardiac
Raport
Tytuł :
Are atrial human pluripotent stem cell-derived cardiomyocytes ready to identify drugs that beat atrial fibrillation?
Autorzy :
Christ T; Institute of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. .; DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Hamburg, Germany. .
Lemoine MD; DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Hamburg, Germany.; Department of Cardiology-, University Heart and Vascular Center, Hamburg, Germany.
Eschenhagen T; Institute of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Hamburg, Germany.
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Źródło :
Nature communications [Nat Commun] 2021 Mar 19; Vol. 12 (1), pp. 1725. Date of Electronic Publication: 2021 Mar 19.
Typ publikacji :
Letter; Comment
MeSH Terms :
Atrial Fibrillation*/drug therapy
Induced Pluripotent Stem Cells*
Pharmaceutical Preparations*
Heart Atria ; Humans ; Myocytes, Cardiac
Opinia redakcyjna
Tytuł :
Umbilical cord blood-derived microglia-like cells to model COVID-19 exposure.
Autorzy :
Sheridan SD; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Center for Genomic Medicine and Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
Thanos JM; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Center for Genomic Medicine and Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
De Guzman RM; Obstetrics, Gynecology, and Reproductive Biology, Harvard Medical School, Boston, MA, USA.; Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA, USA.
McCrea LT; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Center for Genomic Medicine and Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
Horng JE; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Center for Genomic Medicine and Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
Fu T; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Center for Genomic Medicine and Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
Sellgren CM; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Perlis RH; Department of Psychiatry, Harvard Medical School, Boston, MA, USA. .; Center for Genomic Medicine and Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA. .
Edlow AG; Obstetrics, Gynecology, and Reproductive Biology, Harvard Medical School, Boston, MA, USA. .; Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA, USA. .
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Źródło :
Translational psychiatry [Transl Psychiatry] 2021 Mar 19; Vol. 11 (1), pp. 179. Date of Electronic Publication: 2021 Mar 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cellular Reprogramming*
Induced Pluripotent Stem Cells*
Brain/*growth & development
Brain/*immunology
COVID-19/*immunology
Fetal Blood/*immunology
Leukocytes, Mononuclear/*immunology
Microglia/*immunology
Pregnancy Complications, Infectious/*immunology
Adult ; Female ; Humans ; Infant, Newborn ; Pregnancy
Czasopismo naukowe
Tytuł :
Fabrication of 3D Cardiac Microtissue Arrays using Human iPSC-Derived Cardiomyocytes, Cardiac Fibroblasts, and Endothelial Cells.
Autorzy :
Thomas D; Stanford Cardiovascular Institute, Stanford University School of Medicine.
Kim H; Stanford Cardiovascular Institute, Stanford University School of Medicine.
Lopez N; Stanford Cardiovascular Institute, Stanford University School of Medicine.
Wu JC; Stanford Cardiovascular Institute, Stanford University School of Medicine; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine; Department of Radiology, Stanford University School of Medicine; .
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Źródło :
Journal of visualized experiments : JoVE [J Vis Exp] 2021 Mar 14 (169). Date of Electronic Publication: 2021 Mar 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Video-Audio Media
MeSH Terms :
Endothelial Cells/*metabolism
Fibroblasts/*metabolism
Induced Pluripotent Stem Cells/*metabolism
Myocytes, Cardiac/*metabolism
Cell Culture Techniques ; Cell Differentiation ; Humans ; Induced Pluripotent Stem Cells/cytology ; Myocytes, Cardiac/cytology
Czasopismo naukowe
Tytuł :
Revealing Tissue-Specific SARS-CoV-2 Infection and Host Responses using Human Stem Cell-Derived Lung and Cerebral Organoids.
Autorzy :
Tiwari SK; Division of Genetics, Department of Pediatrics, Program in Immunology, Institute for Genomic Medicine, University of California San Diego, 9500 Gilman Drive MC 0762, La Jolla, CA 92093, USA.
Wang S; Division of Genetics, Department of Pediatrics, Program in Immunology, Institute for Genomic Medicine, University of California San Diego, 9500 Gilman Drive MC 0762, La Jolla, CA 92093, USA.
Smith D; Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, 9500 Gilman Drive MC 0762, La Jolla, CA 92093, USA.
Carlin AF; Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, 9500 Gilman Drive MC 0762, La Jolla, CA 92093, USA.
Rana TM; Division of Genetics, Department of Pediatrics, Program in Immunology, Institute for Genomic Medicine, University of California San Diego, 9500 Gilman Drive MC 0762, La Jolla, CA 92093, USA. Electronic address: .
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Źródło :
Stem cell reports [Stem Cell Reports] 2021 Mar 09; Vol. 16 (3), pp. 437-445. Date of Electronic Publication: 2021 Feb 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain/*virology
COVID-19/*virology
Induced Pluripotent Stem Cells/*virology
Lung/*virology
Neural Stem Cells/*virology
Organoids/*virology
SARS-CoV-2/*pathogenicity
Apoptosis/physiology ; Brain/metabolism ; COVID-19/metabolism ; Cells, Cultured ; Complement System Proteins/metabolism ; Epithelial Cells/metabolism ; Epithelial Cells/virology ; Humans ; Induced Pluripotent Stem Cells/metabolism ; Inflammation/metabolism ; Inflammation/virology ; Lung/metabolism ; Neural Stem Cells/metabolism ; Neurons/metabolism ; Neurons/virology ; Organoids/metabolism ; Serine Endopeptidases/metabolism ; Signal Transduction/physiology ; Stem Cells/metabolism ; Stem Cells/virology
Czasopismo naukowe
Tytuł :
Identification of rare and common regulatory variants in pluripotent cells using population-scale transcriptomics.
Autorzy :
Bonder MJ; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, UK. .; European Molecular Biology Laboratory, Genome Biology Unit, Heidelberg, Germany. .; Division of Computational Genomics and Systems Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany. .
Smail C; Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, CA, USA. .; Genomic Medicine Center, Children's Mercy Research Institute and Children's Mercy Kansas City, Kansas City, MO, USA. .
Gloudemans MJ; Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, CA, USA.
Frésard L; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Jakubosky D; Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, CA, USA.; Department of Biomedical Informatics, University of California, San Diego, La Jolla, CA, USA.
D'Antonio M; Department of Pediatrics and Rady Children's Hospital, University of California, San Diego, La Jolla, CA, USA.
Li X; CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Ferraro NM; Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, CA, USA.
Carcamo-Orive I; Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Mirauta B; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, UK.
Seaton DD; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, UK.
Cai N; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, UK.; Wellcome Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.; Helmholtz Pioneer Campus, Helmholtz Zentrum München, Neuherberg, Germany.
Vakili D; UCL Great Ormond Street Institute of Child Health, University College London, London, UK.; Faculty of Medicine, Imperial College London, London, UK.
Horta D; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, UK.
Zhao C; Stanford Center for Undiagnosed Diseases, Stanford University, Stanford, CA, USA.
Zastrow DB; Stanford Center for Undiagnosed Diseases, Stanford University, Stanford, CA, USA.
Bonner DE; Stanford Center for Undiagnosed Diseases, Stanford University, Stanford, CA, USA.
Wheeler MT; Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Stanford Center for Undiagnosed Diseases, Stanford University, Stanford, CA, USA.
Kilpinen H; Wellcome Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.; UCL Great Ormond Street Institute of Child Health, University College London, London, UK.; Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland.; Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.
Knowles JW; Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Smith EN; Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA, USA.
Frazer KA; Department of Pediatrics and Rady Children's Hospital, University of California, San Diego, La Jolla, CA, USA.; Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA, USA.
Montgomery SB; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. .; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA. .
Stegle O; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, UK. .; European Molecular Biology Laboratory, Genome Biology Unit, Heidelberg, Germany. .; Division of Computational Genomics and Systems Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany. .; Wellcome Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK. .
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Corporate Authors :
HipSci Consortium
iPSCORE consortium
Undiagnosed Diseases Network
PhLiPS consortium
Źródło :
Nature genetics [Nat Genet] 2021 Mar; Vol. 53 (3), pp. 313-321. Date of Electronic Publication: 2021 Mar 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Genetic Variation*
Quantitative Trait Loci*
Induced Pluripotent Stem Cells/*physiology
Bardet-Biedl Syndrome/genetics ; Calcium Channels/genetics ; Cell Line ; Cerebellar Ataxia/genetics ; DNA Methylation ; Gene Expression ; Humans ; Induced Pluripotent Stem Cells/cytology ; Polymorphism, Single Nucleotide ; Proteins/genetics ; Rare Diseases/genetics ; Regulatory Sequences, Nucleic Acid ; Sequence Analysis, RNA ; Whole Genome Sequencing
Czasopismo naukowe
Tytuł :
Atypical Neurogenesis in Induced Pluripotent Stem Cells From Autistic Individuals.
Autorzy :
Adhya D; Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom; Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
Swarup V; Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, California.
Nagy R; Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
Dutan L; Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
Shum C; Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
Valencia-Alarcón EP; Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
Jozwik KM; Cancer Research UK Cambridge Institute, Cambridge, United Kingdom.
Mendez MA; Department of Forensic and Neurodevelopmental Sciences, Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
Horder J; Department of Forensic and Neurodevelopmental Sciences, Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
Loth E; Department of Forensic and Neurodevelopmental Sciences, Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
Nowosiad P; Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
Lee I; Behavioural and Brain Sciences Unit, Population Policy Practice Programme, Great Ormond Street Institute of Child Health, University College London, London, United Kingdom.
Skuse D; Behavioural and Brain Sciences Unit, Population Policy Practice Programme, Great Ormond Street Institute of Child Health, University College London, London, United Kingdom.
Flinter FA; Department of Clinical Genetics, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom.
Murphy D; Department of Forensic and Neurodevelopmental Sciences, Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
McAlonan G; Department of Forensic and Neurodevelopmental Sciences, Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
Geschwind DH; Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, California; Department of Human Genetics, University of California, Los Angeles, Los Angeles, California.
Price J; Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; MRC Centre for Neurodevelopmental Disorders, King's College London, London, United Kingdom.
Carroll J; Cancer Research UK Cambridge Institute, Cambridge, United Kingdom.
Srivastava DP; Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; MRC Centre for Neurodevelopmental Disorders, King's College London, London, United Kingdom. Electronic address: .
Baron-Cohen S; Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom.
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Źródło :
Biological psychiatry [Biol Psychiatry] 2021 Mar 01; Vol. 89 (5), pp. 486-496. Date of Electronic Publication: 2020 Jun 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Autistic Disorder*
Induced Pluripotent Stem Cells*
Cell Differentiation ; Female ; Humans ; Neurogenesis ; Neurons ; Pregnancy
Czasopismo naukowe
Tytuł :
Dissecting the non-neuronal cell contribution to Parkinson's disease pathogenesis using induced pluripotent stem cells.
Autorzy :
Pons-Espinal M; Department of Pathology and Experimental Therapeutics, Bellvitge University Hospital-IDIBELL, 08908, Hospitalet de Llobregat, Spain. .; Institute of Biomedicine (IBUB) of the University of Barcelona (UB), 08028, Barcelona, Spain. .
Blasco-Agell L; Department of Pathology and Experimental Therapeutics, Bellvitge University Hospital-IDIBELL, 08908, Hospitalet de Llobregat, Spain.; Institute of Biomedicine (IBUB) of the University of Barcelona (UB), 08028, Barcelona, Spain.
Consiglio A; Department of Pathology and Experimental Therapeutics, Bellvitge University Hospital-IDIBELL, 08908, Hospitalet de Llobregat, Spain. .; Institute of Biomedicine (IBUB) of the University of Barcelona (UB), 08028, Barcelona, Spain. .; Department of Molecular and Translational Medicine, University of Brescia, Piazza del Mercato, 15, 25121, Brescia, BS, Italy. .
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Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2021 Mar; Vol. 78 (5), pp. 2081-2094. Date of Electronic Publication: 2020 Nov 18.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Dopaminergic Neurons/*metabolism
Induced Pluripotent Stem Cells/*metabolism
Neuroglia/*metabolism
Parkinson Disease/*metabolism
Animals ; Astrocytes/cytology ; Astrocytes/metabolism ; Cell Culture Techniques/methods ; Dopaminergic Neurons/cytology ; Humans ; Induced Pluripotent Stem Cells/cytology ; Neuroglia/cytology ; Organoids/cytology ; Organoids/metabolism ; Parkinson Disease/pathology ; Substantia Nigra/cytology ; Substantia Nigra/metabolism
Czasopismo naukowe
Tytuł :
The When and Where: Molecular and Cellular Convergence in Autism.
Autorzy :
Schafer ST; Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California.
Gage FH; Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California. Electronic address: .
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Źródło :
Biological psychiatry [Biol Psychiatry] 2021 Mar 01; Vol. 89 (5), pp. 419-420.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Autism Spectrum Disorder*/genetics
Autistic Disorder*/genetics
Induced Pluripotent Stem Cells*
Humans ; Neurogenesis
Czasopismo naukowe
Tytuł :
Human pituitary development and application of iPSCs for pituitary disease.
Autorzy :
Matsumoto R; Department of Diabetes and Endocrinology, Kobe University Graduate School of Medicine, Kobe, Japan.; Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan.
Takahashi Y; Department of Diabetes and Endocrinology, Kobe University Graduate School of Medicine, Kobe, Japan. .; Department of Diabetes and Endocrinology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan. .
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Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2021 Mar; Vol. 78 (5), pp. 2069-2079. Date of Electronic Publication: 2020 Nov 18.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Cell Differentiation*
Induced Pluripotent Stem Cells/*metabolism
Pituitary Diseases/*metabolism
Pituitary Gland/*metabolism
Pluripotent Stem Cells/*metabolism
Animals ; Cell Culture Techniques/methods ; Cells, Cultured ; Humans ; Induced Pluripotent Stem Cells/cytology ; Pituitary Diseases/pathology ; Pituitary Gland/cytology ; Pituitary Gland/physiology ; Pluripotent Stem Cells/cytology ; Regenerative Medicine/methods
Czasopismo naukowe
Tytuł :
Human iPSC-Based Modeling of Central Nerve System Disorders for Drug Discovery.
Autorzy :
Qian L; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Ronald Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Tcw J; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Ronald Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jan 26; Vol. 22 (3). Date of Electronic Publication: 2021 Jan 26.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Central Nervous System Diseases/*drug therapy
Drug Discovery/*methods
Induced Pluripotent Stem Cells/*cytology
Induced Pluripotent Stem Cells/*drug effects
Tissue Engineering/*methods
Animals ; COVID-19/drug therapy ; COVID-19/pathology ; Central Nervous System Diseases/pathology ; Drug Discovery/instrumentation ; Drug Evaluation, Preclinical/instrumentation ; Drug Evaluation, Preclinical/methods ; Humans ; Induced Pluripotent Stem Cells/pathology ; Lab-On-A-Chip Devices ; Organoids/cytology ; Organoids/drug effects ; Organoids/pathology ; Tissue Engineering/instrumentation ; Zika Virus Infection/drug therapy ; Zika Virus Infection/pathology
Czasopismo naukowe
Tytuł :
Method for the Generation of Induced Hematopoietic Stem Cells.
Autorzy :
Olender L; The Shraga Segal Department for Microbiology, Immunology, and Genetics, Faculty of Health Sciences, National Institute for Biotechnology in the Negev, The Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Levy K; The Shraga Segal Department for Microbiology, Immunology, and Genetics, Faculty of Health Sciences, National Institute for Biotechnology in the Negev, The Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Gazit R; The Shraga Segal Department for Microbiology, Immunology, and Genetics, Faculty of Health Sciences, National Institute for Biotechnology in the Negev, The Ben-Gurion University of the Negev, Beer-Sheva, Israel. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2185, pp. 399-410.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cellular Reprogramming*
Cellular Reprogramming Techniques*
Hematopoietic Stem Cells*/cytology
Hematopoietic Stem Cells*/metabolism
Induced Pluripotent Stem Cells*/cytology
Induced Pluripotent Stem Cells*/metabolism
Animals ; HEK293 Cells ; Humans ; Mice
Czasopismo naukowe

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