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Wyszukujesz frazę ""INOSITOL 1,4,5-TRISPHOSPHATE"" wg kryterium: Temat


Tytuł :
Dual mechanisms of Ca oscillations in hepatocytes.
Autorzy :
Cloete I; Department of Mathematics, University of Auckland, Auckland 1142, New Zealand.
Bartlett PJ; Department of Pharmacology and Physiology, New Jersey Medical School Rutgers, The State University of New Jersey, Newark, NJ 07103, United States.
Kirk V; Department of Mathematics, University of Auckland, Auckland 1142, New Zealand.
Thomas AP; Department of Pharmacology and Physiology, New Jersey Medical School Rutgers, The State University of New Jersey, Newark, NJ 07103, United States.
Sneyd J; Department of Mathematics, University of Auckland, Auckland 1142, New Zealand.
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Źródło :
Journal of theoretical biology [J Theor Biol] 2020 Oct 21; Vol. 503, pp. 110390. Date of Electronic Publication: 2020 Jul 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium*/metabolism
Inositol 1,4,5-Trisphosphate*
Calcium Signaling ; Hepatocytes/metabolism ; Inositol 1,4,5-Trisphosphate Receptors/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
Biological Regulatory Network (BRN) Analysis and Molecular Docking Simulations to Probe the Modulation of IP 3 R Mediated Ca Signaling in Cancer.
Autorzy :
Ismatullah H; Research Center for Modeling and Simulation (RCMS), National University of Sciences and Technology (NUST), Academic-I Building, H-12 Islamabad 44000, Pakistan.
Jabeen I; Research Center for Modeling and Simulation (RCMS), National University of Sciences and Technology (NUST), Academic-I Building, H-12 Islamabad 44000, Pakistan.
Saeed MT; Research Center for Modeling and Simulation (RCMS), National University of Sciences and Technology (NUST), Academic-I Building, H-12 Islamabad 44000, Pakistan.
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Źródło :
Genes [Genes (Basel)] 2020 Dec 29; Vol. 12 (1). Date of Electronic Publication: 2020 Dec 29.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Calcium Signaling/*genetics
Gene Regulatory Networks/*drug effects
Inositol 1,4,5-Trisphosphate Receptors/*genetics
Neoplasms/*genetics
Antineoplastic Agents/therapeutic use ; Apoptosis/drug effects ; Apoptosis/genetics ; Autophagy/drug effects ; Calcium/metabolism ; Calcium Signaling/drug effects ; Carcinogenesis/drug effects ; Carcinogenesis/genetics ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Datasets as Topic ; Humans ; Inositol 1,4,5-Trisphosphate/metabolism ; Inositol 1,4,5-Trisphosphate Receptors/antagonists & inhibitors ; Inositol 1,4,5-Trisphosphate Receptors/metabolism ; Molecular Docking Simulation ; Neoplasms/drug therapy ; Neoplasms/pathology ; Protein Interaction Mapping ; Protein Interaction Maps/drug effects ; Protein Interaction Maps/genetics
Czasopismo naukowe
Tytuł :
Bok binds to a largely disordered loop in the coupling domain of type 1 inositol 1,4,5-trisphosphate receptor.
Autorzy :
Szczesniak LM; Department of Pharmacology, SUNY Upstate Medical University, Syracuse, NY, USA.
Bonzerato CG; Department of Pharmacology, SUNY Upstate Medical University, Syracuse, NY, USA.
Schulman JJ; Department of Pharmacology, SUNY Upstate Medical University, Syracuse, NY, USA.
Bah A; Department of Biochemistry, Department of Molecular Biology, SUNY Upstate Medical University, Syracuse, NY, USA.
Wojcikiewicz RJH; Department of Pharmacology, SUNY Upstate Medical University, Syracuse, NY, USA. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 May 14; Vol. 553, pp. 180-186. Date of Electronic Publication: 2021 Mar 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Inositol 1,4,5-Trisphosphate Receptors/*metabolism
Proto-Oncogene Proteins c-bcl-2/*metabolism
Binding Sites/genetics ; Humans ; Inositol 1,4,5-Trisphosphate Receptors/chemistry ; Inositol 1,4,5-Trisphosphate Receptors/genetics ; Models, Molecular ; Molecular Targeted Therapy ; Protein Binding/genetics ; Protein Domains ; Protein Structure, Secondary ; Proto-Oncogene Proteins c-bcl-2/chemistry ; Sequence Deletion
Czasopismo naukowe
Tytuł :
Intercellular Bridge Mediates Ca Diffusion.
Autorzy :
Xing F; The Key Laboratory of Weak-Light Nonlinear Photonics of Education Ministry, School of Physics and TEDA Institute of Applied Physics, Nankai University, Tianjin, China.
Qu S; The Key Laboratory of Weak-Light Nonlinear Photonics of Education Ministry, School of Physics and TEDA Institute of Applied Physics, Nankai University, Tianjin, China.
Liu J; The Key Laboratory of Weak-Light Nonlinear Photonics of Education Ministry, School of Physics and TEDA Institute of Applied Physics, Nankai University, Tianjin, China.
Yang J; The Key Laboratory of Weak-Light Nonlinear Photonics of Education Ministry, School of Physics and TEDA Institute of Applied Physics, Nankai University, Tianjin, China.
Hu F; The Key Laboratory of Weak-Light Nonlinear Photonics of Education Ministry, School of Physics and TEDA Institute of Applied Physics, Nankai University, Tianjin, China.
Drevenšek-Olenik I; Faculty of Mathematics and Physics, University of Ljubljana, and J. Stefan Institute, Ljubljana, Slovenia.
Pan L; The Key Laboratory of Weak-Light Nonlinear Photonics of Education Ministry, School of Physics and TEDA Institute of Applied Physics, Nankai University, Tianjin, China. Electronic address: .
Xu J; The Key Laboratory of Weak-Light Nonlinear Photonics of Education Ministry, School of Physics and TEDA Institute of Applied Physics, Nankai University, Tianjin, China; Collaborative Innovation Center of Extreme Optics, Shanxi University, Taiyuan, Shanxi, China.
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Źródło :
Biophysical journal [Biophys J] 2020 Mar 10; Vol. 118 (5), pp. 1196-1204. Date of Electronic Publication: 2020 Jan 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium*/metabolism
Inositol 1,4,5-Trisphosphate*/metabolism
Calcium Signaling ; Diffusion ; Endoplasmic Reticulum/metabolism ; Inositol 1,4,5-Trisphosphate Receptors/metabolism
Czasopismo naukowe
Tytuł :
Impaired calcium signaling in astrocytes modulates autism spectrum disorder-like behaviors in mice.
Autorzy :
Wang Q; State Key Laboratory of Organ Failure Research, Key Laboratory of Mental Health of the Ministry of Education, Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Guangdong Province Key Laboratory of Psychiatric Disorders, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, P. R. China.
Kong Y; State Key Laboratory of Organ Failure Research, Key Laboratory of Mental Health of the Ministry of Education, Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Guangdong Province Key Laboratory of Psychiatric Disorders, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, P. R. China.
Wu DY; State Key Laboratory of Organ Failure Research, Key Laboratory of Mental Health of the Ministry of Education, Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Guangdong Province Key Laboratory of Psychiatric Disorders, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, P. R. China.
Liu JH; State Key Laboratory of Organ Failure Research, Key Laboratory of Mental Health of the Ministry of Education, Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Guangdong Province Key Laboratory of Psychiatric Disorders, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, P. R. China.
Jie W; State Key Laboratory of Organ Failure Research, Key Laboratory of Mental Health of the Ministry of Education, Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Guangdong Province Key Laboratory of Psychiatric Disorders, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, P. R. China.
You QL; State Key Laboratory of Organ Failure Research, Key Laboratory of Mental Health of the Ministry of Education, Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Guangdong Province Key Laboratory of Psychiatric Disorders, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, P. R. China.
Huang L; State Key Laboratory of Organ Failure Research, Key Laboratory of Mental Health of the Ministry of Education, Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Guangdong Province Key Laboratory of Psychiatric Disorders, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, P. R. China.
Hu J; State Key Laboratory of Organ Failure Research, Key Laboratory of Mental Health of the Ministry of Education, Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Guangdong Province Key Laboratory of Psychiatric Disorders, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, P. R. China.
Chu HD; State Key Laboratory of Organ Failure Research, Key Laboratory of Mental Health of the Ministry of Education, Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Guangdong Province Key Laboratory of Psychiatric Disorders, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, P. R. China.
Gao F; The Ministry of Education of China, School of Basic Medical Sciences, Institute of Neuroscience and Department of Neurology of the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, P. R. China.
Hu NY; State Key Laboratory of Organ Failure Research, Key Laboratory of Mental Health of the Ministry of Education, Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Guangdong Province Key Laboratory of Psychiatric Disorders, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, P. R. China.
Luo ZC; State Key Laboratory of Organ Failure Research, Key Laboratory of Mental Health of the Ministry of Education, Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Guangdong Province Key Laboratory of Psychiatric Disorders, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, P. R. China.
Li XW; State Key Laboratory of Organ Failure Research, Key Laboratory of Mental Health of the Ministry of Education, Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Guangdong Province Key Laboratory of Psychiatric Disorders, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, P. R. China.
Li SJ; State Key Laboratory of Organ Failure Research, Key Laboratory of Mental Health of the Ministry of Education, Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Guangdong Province Key Laboratory of Psychiatric Disorders, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, P. R. China.
Wu ZF; State Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.; PKU-IDG/McGovern Institute for Brain Research, Beijing, China.
Li YL; State Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.; PKU-IDG/McGovern Institute for Brain Research, Beijing, China.; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.; Chinese Institute for Brain Research, Beijing, China.
Yang JM; State Key Laboratory of Organ Failure Research, Key Laboratory of Mental Health of the Ministry of Education, Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Guangdong Province Key Laboratory of Psychiatric Disorders, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, P. R. China. .
Gao TM; State Key Laboratory of Organ Failure Research, Key Laboratory of Mental Health of the Ministry of Education, Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Guangdong Province Key Laboratory of Psychiatric Disorders, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, P. R. China. .
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Źródło :
Nature communications [Nat Commun] 2021 May 31; Vol. 12 (1), pp. 3321. Date of Electronic Publication: 2021 May 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenosine Triphosphate/*metabolism
Astrocytes/*pathology
Autism Spectrum Disorder/*pathology
Calcium Signaling/*physiology
Inositol 1,4,5-Trisphosphate Receptors/*deficiency
Animals ; Autism Spectrum Disorder/genetics ; Autism Spectrum Disorder/physiopathology ; Behavior, Animal ; Calcium/metabolism ; Disease Models, Animal ; GABAergic Neurons/physiology ; Humans ; Inositol 1,4,5-Trisphosphate Receptors/genetics ; Male ; Mice ; Mice, Knockout ; Prefrontal Cortex/cytology ; Prefrontal Cortex/pathology ; Prefrontal Cortex/physiopathology ; Synaptic Transmission/physiology
Czasopismo naukowe
Tytuł :
Hydrogen peroxide depolarizes mitochondria and inhibits IP 3 -evoked Ca release in the endothelium of intact arteries.
Autorzy :
Zhang X; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, UK.
Lee MD; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, UK.
Wilson C; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, UK.
McCarron JG; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, UK. Electronic address: .
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Źródło :
Cell calcium [Cell Calcium] 2019 Dec; Vol. 84, pp. 102108. Date of Electronic Publication: 2019 Nov 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Inositol 1,4,5-Trisphosphate Receptors*/metabolism
Endothelial Cells/*physiology
Hydrogen Peroxide/*metabolism
Mesenteric Arteries/*cytology
Mitochondria/*metabolism
Acetylcholine/metabolism ; Animals ; Calcium Signaling ; Carbonyl Cyanide m-Chlorophenyl Hydrazone/pharmacology ; Cells, Cultured ; Feedback, Physiological ; Inositol 1,4,5-Trisphosphate/metabolism ; Membrane Potential, Mitochondrial ; Photolysis ; Rats
Czasopismo naukowe
Tytuł :
Carbenoxolone and 18β-glycyrrhetinic acid inhibit inositol 1,4,5-trisphosphate-mediated endothelial cell calcium signalling and depolarise mitochondria.
Autorzy :
Buckley C; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK.
Zhang X; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK.
Wilson C; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK.
McCarron JG; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK.
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Źródło :
British journal of pharmacology [Br J Pharmacol] 2021 Feb; Vol. 178 (4), pp. 896-912. Date of Electronic Publication: 2021 Jan 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carbenoxolone*/metabolism
Inositol 1,4,5-Trisphosphate*/metabolism
Calcium/metabolism ; Calcium Signaling ; Endothelial Cells/metabolism ; Gap Junctions/metabolism ; Glycyrrhetinic Acid/analogs & derivatives ; Mitochondria/metabolism
Czasopismo naukowe
Tytuł :
ER-luminal [Ca -binding protein.
Autorzy :
Vais H; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Wang M; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Mallilankaraman K; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Payne R; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
McKennan C; Department of Statistics, University of Pittsburgh, Pittsburgh, United States.
Lock JT; Department of Neurobiology and Behavior, University of California, Irvine, United States.
Spruce LA; Proteomics Core Facility, The Children's Hospital of Philadelphia, Philadelphia, United States.
Fiest C; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Chan MY; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Parker I; Department of Neurobiology and Behavior, University of California, Irvine, United States.; Department of Physiology and Biophysics, University of California, Irvine, United States.
Seeholzer SH; Proteomics Core Facility, The Children's Hospital of Philadelphia, Philadelphia, United States.
Foskett JK; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Mak DD; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
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Źródło :
ELife [Elife] 2020 May 18; Vol. 9. Date of Electronic Publication: 2020 May 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Annexin A1/*metabolism
Calcium/*metabolism
Calcium Signaling/*physiology
Endoplasmic Reticulum/*metabolism
Inositol 1,4,5-Trisphosphate Receptors/*metabolism
A549 Cells ; Animals ; Calcium-Binding Proteins/metabolism ; Cell Line, Tumor ; Cell Physiological Phenomena/physiology ; Chickens ; HEK293 Cells ; Humans ; Inositol 1,4,5-Trisphosphate/metabolism ; Ion Channel Gating ; Mice ; Patch-Clamp Techniques ; Rats
Czasopismo naukowe
Tytuł :
Disease-associated mutations in inositol 1,4,5-trisphosphate receptor subunits impair channel function.
Autorzy :
Terry LE; Department of Pharmacology and Physiology, University of Rochester, Rochester, New York, USA.
Alzayady KJ; Department of Pharmacology and Physiology, University of Rochester, Rochester, New York, USA.
Wahl AM; Department of Pharmacology and Physiology, University of Rochester, Rochester, New York, USA.
Malik S; Department of Pharmacology and Physiology, University of Rochester, Rochester, New York, USA.
Yule DI; Department of Pharmacology and Physiology, University of Rochester, Rochester, New York, USA. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Dec 25; Vol. 295 (52), pp. 18160-18178. Date of Electronic Publication: 2020 Oct 22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Ion Channel Gating*
Mutation*
B-Lymphocytes/*metabolism
Calcium/*metabolism
Inositol 1,4,5-Trisphosphate/*metabolism
Inositol 1,4,5-Trisphosphate Receptors/*metabolism
Amino Acid Sequence ; Animals ; B-Lymphocytes/cytology ; Calcium Signaling ; Chickens ; Inositol 1,4,5-Trisphosphate Receptors/genetics ; Protein Multimerization ; Sequence Homology
Czasopismo naukowe
Tytuł :
Single-nucleotide polymorphisms responsible for pseudo-albinism and hypermelanosis in Japanese flounder (Paralichthys olivaceus) and reveal two genes related to malpigmentation.
Autorzy :
Zhang B; Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources (Shanghai Ocean University), Shanghai, China.; Ministry of Education; International Research Center for Marine Biosciences, Shanghai Ocean University, Ministry of Science and Technology, Shanghai, China.; National Demonstration Center for Experimental Fisheries Science Education, Shanghai Ocean University, Shanghai, 201306, China.; Tianjin Fisheries Research Institute, Tianjin, China.
Peng K; Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources (Shanghai Ocean University), Shanghai, China.; Ministry of Education; International Research Center for Marine Biosciences, Shanghai Ocean University, Ministry of Science and Technology, Shanghai, China.; National Demonstration Center for Experimental Fisheries Science Education, Shanghai Ocean University, Shanghai, 201306, China.
Che J; Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources (Shanghai Ocean University), Shanghai, China.
Zhao N; Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources (Shanghai Ocean University), Shanghai, China.; Tianjin Haolingsaiao Biotechnology Co, Ltd, Tianjin, China.
Jia L; Tianjin Fisheries Research Institute, Tianjin, China.
Zhao D; Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources (Shanghai Ocean University), Shanghai, China.
Huang Y; Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources (Shanghai Ocean University), Shanghai, China.
Liao Y; Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources (Shanghai Ocean University), Shanghai, China.
He X; Tianjin Fisheries Research Institute, Tianjin, China.
Gong X; Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources (Shanghai Ocean University), Shanghai, China. .
Bao B; Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources (Shanghai Ocean University), Shanghai, China. .
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Źródło :
Fish physiology and biochemistry [Fish Physiol Biochem] 2021 Apr; Vol. 47 (2), pp. 339-350. Date of Electronic Publication: 2021 Jan 06.
Typ publikacji :
Journal Article
MeSH Terms :
Polymorphism, Single Nucleotide*
Fish Proteins/*metabolism
Flounder/*genetics
Flounder/*physiology
Inositol 1,4,5-Trisphosphate Receptors/*metabolism
Skin Pigmentation/*genetics
Adenylyl Cyclases/genetics ; Adenylyl Cyclases/metabolism ; Animals ; Fish Proteins/genetics ; Genotype ; Inositol 1,4,5-Trisphosphate Receptors/genetics
Czasopismo naukowe
Tytuł :
Calcium channel ITPR2 and mitochondria-ER contacts promote cellular senescence and aging.
Autorzy :
Ziegler DV; Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Centre Léon Bérard, Université de Lyon, Lyon, France.
Vindrieux D; Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Centre Léon Bérard, Université de Lyon, Lyon, France.
Goehrig D; Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Centre Léon Bérard, Université de Lyon, Lyon, France.
Jaber S; Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Centre Léon Bérard, Université de Lyon, Lyon, France.
Collin G; Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Centre Léon Bérard, Université de Lyon, Lyon, France.
Griveau A; Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Centre Léon Bérard, Université de Lyon, Lyon, France.
Wiel C; Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Centre Léon Bérard, Université de Lyon, Lyon, France.
Bendridi N; CarMeN Laboratory, INSERM UMR-1060, Lyon 1 University, INRA U1397, F-69921, Oullins, France.
Djebali S; Centre International de Recherche en Infectiologie, Inserm U1111, CNRS UMR5308, École Normale Supérieure de Lyon, Université de Lyon, Université Claude Bernard Lyon 1, Lyon, France.
Farfariello V; INSERM U1003, Laboratoire d'Excellence, Canaux Ioniques d'Intérêt Thérapeutique, Équipe Labellisée Par la Ligue Nationale Contre le Cancer, SIRIC ONCOLille, Université des Sciences et Technologies de Lille, Villeneuve d'Ascq, France.
Prevarskaya N; INSERM U1003, Laboratoire d'Excellence, Canaux Ioniques d'Intérêt Thérapeutique, Équipe Labellisée Par la Ligue Nationale Contre le Cancer, SIRIC ONCOLille, Université des Sciences et Technologies de Lille, Villeneuve d'Ascq, France.
Payen L; Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Centre Léon Bérard, Université de Lyon, Lyon, France.
Marvel J; Centre International de Recherche en Infectiologie, Inserm U1111, CNRS UMR5308, École Normale Supérieure de Lyon, Université de Lyon, Université Claude Bernard Lyon 1, Lyon, France.
Aubert S; Institut de Pathologie, Centre de Biologie Pathologie, CHRU de Lille, Faculté de Médecine, Université de Lille, Lille Cedex, France.
Flaman JM; Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Centre Léon Bérard, Université de Lyon, Lyon, France.
Rieusset J; CarMeN Laboratory, INSERM UMR-1060, Lyon 1 University, INRA U1397, F-69921, Oullins, France.
Martin N; Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Centre Léon Bérard, Université de Lyon, Lyon, France.
Bernard D; Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Centre Léon Bérard, Université de Lyon, Lyon, France. .
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Źródło :
Nature communications [Nat Commun] 2021 Feb 01; Vol. 12 (1), pp. 720. Date of Electronic Publication: 2021 Feb 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cellular Senescence/*physiology
Endoplasmic Reticulum/*metabolism
Inositol 1,4,5-Trisphosphate Receptors/*metabolism
Longevity/*physiology
Mitochondria/*metabolism
Animals ; Calcium/metabolism ; Endoplasmic Reticulum/ultrastructure ; Female ; Fibroblasts ; HEK293 Cells ; Humans ; Inositol 1,4,5-Trisphosphate Receptors/genetics ; Male ; Mice ; Mice, Knockout ; Microscopy, Confocal ; Mitochondria/ultrastructure ; RNA, Small Interfering ; Refractory Period, Electrophysiological ; Single-Cell Analysis
Czasopismo naukowe
Tytuł :
IP 3 mediated global Ca release.
Autorzy :
Lock JT; Department of Neurobiology & Behavior, UC Irvine, Irvine, United States.
Parker I; Department of Neurobiology & Behavior, UC Irvine, Irvine, United States.; Department of Physiology & Biophysics, UC Irvine, Irvine, United States.
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Źródło :
ELife [Elife] 2020 May 12; Vol. 9. Date of Electronic Publication: 2020 May 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Calcium Signaling*
Calcium/*metabolism
Inositol 1,4,5-Trisphosphate/*metabolism
Cytosol/metabolism ; Endoplasmic Reticulum/metabolism ; HEK293 Cells ; HeLa Cells ; Humans ; Inositol 1,4,5-Trisphosphate Receptors/metabolism ; Kinetics
Czasopismo naukowe
Tytuł :
IP 3 Receptor Plasticity Underlying Diverse Functions.
Autorzy :
Hamada K; Laboratory of Cell Calcium Signaling, Shanghai Institute for Advanced Immunochemical Studies (SIAIS), ShanghaiTech University, Shanghai, 201210, China; email: , .
Mikoshiba K; Laboratory of Cell Calcium Signaling, Shanghai Institute for Advanced Immunochemical Studies (SIAIS), ShanghaiTech University, Shanghai, 201210, China; email: , .
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Źródło :
Annual review of physiology [Annu Rev Physiol] 2020 Feb 10; Vol. 82, pp. 151-176. Date of Electronic Publication: 2019 Nov 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Inositol 1,4,5-Trisphosphate Receptors/*physiology
Allosteric Regulation ; Animals ; Calcium Channels/metabolism ; Calcium Signaling ; Humans ; Inositol 1,4,5-Trisphosphate/metabolism ; Inositol 1,4,5-Trisphosphate/physiology ; Inositol 1,4,5-Trisphosphate Receptors/genetics
Czasopismo naukowe
Tytuł :
Genetic analyses uncover pleiotropic compensatory roles for Drosophila Nucleobindin-1 in inositol trisphosphate-mediated intracellular calcium homeostasis.
Autorzy :
Balasubramanian V; Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology-Madras, Chennai 600036, India.; Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology-Madras, Chennai 600036, India.
Srinivasan B; Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology-Madras, Chennai 600036, India.; Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology-Madras, Chennai 600036, India.
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Źródło :
Genome [Genome] 2020 Feb; Vol. 63 (2), pp. 61-90. Date of Electronic Publication: 2019 Sep 26.
Typ publikacji :
Journal Article
MeSH Terms :
Calcium/*metabolism
Calcium-Binding Proteins/*physiology
Drosophila Proteins/*physiology
Inositol 1,4,5-Trisphosphate Receptors/*genetics
Nucleobindins/*physiology
Alleles ; Amino Acid Motifs ; Animals ; Calcium-Binding Proteins/chemistry ; Calcium-Binding Proteins/genetics ; Calcium-Binding Proteins/metabolism ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Drosophila Proteins/chemistry ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Drosophila melanogaster/genetics ; Drosophila melanogaster/growth & development ; Drosophila melanogaster/metabolism ; GTP-Binding Protein alpha Subunits/metabolism ; Genes, Lethal ; Genetic Pleiotropy ; Golgi Apparatus/metabolism ; Homeostasis ; Humans ; Inositol 1,4,5-Trisphosphate/metabolism ; Mutation ; Nucleobindins/chemistry ; Nucleobindins/genetics ; Nucleobindins/metabolism ; Protein Domains ; Structural Homology, Protein
Czasopismo naukowe
Tytuł :
IP3R Channels in Male Reproduction.
Autorzy :
Zhang X; Institute of Reproductive Medicine, Medical School, Nantong University, Nantong 226019, China.; Institute of Life Science, Nanchang University, Nanchang 330031, China.
Huang R; Institute of Reproductive Medicine, Medical School, Nantong University, Nantong 226019, China.
Zhou Y; Institute of Reproductive Medicine, Medical School, Nantong University, Nantong 226019, China.
Zhou W; Institute of Reproductive Medicine, Medical School, Nantong University, Nantong 226019, China.
Zeng X; Institute of Reproductive Medicine, Medical School, Nantong University, Nantong 226019, China.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Dec 02; Vol. 21 (23). Date of Electronic Publication: 2020 Dec 02.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Inositol 1,4,5-Trisphosphate Receptors/*metabolism
Reproduction/*physiology
Animals ; Calcium/metabolism ; Calcium Signaling ; Disease Susceptibility ; Gene Expression Regulation ; Humans ; Infertility, Male/etiology ; Infertility, Male/metabolism ; Inositol 1,4,5-Trisphosphate Receptors/chemistry ; Inositol 1,4,5-Trisphosphate Receptors/genetics ; Male ; Sex Factors ; Signal Transduction ; Spermatogenesis/genetics ; Spermatozoa/physiology ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Modulation of flight and feeding behaviours requires presynaptic IP 3 Rs in dopaminergic neurons.
Autorzy :
Sharma A; National Centre for Biological Sciences, TIFR, Bangalore, India.
Hasan G; National Centre for Biological Sciences, TIFR, Bangalore, India.
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Źródło :
ELife [Elife] 2020 Nov 06; Vol. 9. Date of Electronic Publication: 2020 Nov 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Video-Audio Media
MeSH Terms :
Dopaminergic Neurons/*physiology
Drosophila Proteins/*physiology
Drosophila melanogaster/*physiology
Feeding Behavior/*physiology
Flight, Animal/*physiology
Inositol 1,4,5-Trisphosphate Receptors/*physiology
Animals ; Dopaminergic Neurons/metabolism ; Drosophila Proteins/metabolism ; Drosophila melanogaster/metabolism ; Inositol 1,4,5-Trisphosphate Receptors/metabolism ; Male ; Synaptic Vesicles/metabolism ; Synaptic Vesicles/physiology
Czasopismo naukowe
Tytuł :
ORP4L couples IP 3 to ITPR1 in control of endoplasmic reticulum calcium release.
Autorzy :
Cao X; Department of Biology, Jinan University, Guangzhou, China.
Chen J; Department of Biology, Jinan University, Guangzhou, China.
Li D; Department of Biology, Jinan University, Guangzhou, China.
Xie P; Department of Biology, Jinan University, Guangzhou, China.
Xu M; Department of Biology, Jinan University, Guangzhou, China.
Lin W; Department of Biology, Jinan University, Guangzhou, China.
Li S; Department of Biology, Jinan University, Guangzhou, China.
Pan G; Department of Biology, Jinan University, Guangzhou, China.
Tang Y; Department of Biology, Jinan University, Guangzhou, China.
Xu J; Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.
Olkkonen VM; Minerva Foundation Institute for Medical Research, Biomedicum Helsinki 2U, Helsinki, Finland.
Yan D; Department of Biology, Jinan University, Guangzhou, China.
Zhong W; Department of Biology, Jinan University, Guangzhou, China.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2019 Dec; Vol. 33 (12), pp. 13852-13865. Date of Electronic Publication: 2019 Oct 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium/*metabolism
Endoplasmic Reticulum/*metabolism
Inositol 1,4,5-Trisphosphate Receptors/*metabolism
Receptors, Steroid/*metabolism
Cell Line, Tumor ; Cell Membrane/metabolism ; Cell Survival/physiology ; Cytosol/metabolism ; Humans ; Inositol 1,4,5-Trisphosphate/metabolism ; Jurkat Cells ; Mitochondria/metabolism ; Oxidative Phosphorylation ; Phospholipase C beta/metabolism
Czasopismo naukowe
Tytuł :
Caspr2 interacts with type 1 inositol 1,4,5-trisphosphate receptor in the developing cerebellum and regulates Purkinje cell morphology.
Autorzy :
Argent L; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.
Winter F; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.
Prickett I; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.
Carrasquero-Ordaz M; Department of Biochemistry, University of Oxford, Oxford, United Kingdom.
Olsen AL; Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Kramer H; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.
Lancaster E; Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Becker EBE; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Sep 04; Vol. 295 (36), pp. 12716-12726. Date of Electronic Publication: 2020 Jul 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Inositol 1,4,5-Trisphosphate Receptors/*metabolism
Membrane Proteins/*metabolism
Nerve Tissue Proteins/*metabolism
Purkinje Cells/*metabolism
Animals ; HEK293 Cells ; Humans ; Inositol 1,4,5-Trisphosphate Receptors/genetics ; Membrane Proteins/genetics ; Mice ; Mice, Knockout ; Nerve Tissue Proteins/genetics ; Protein Domains ; Purkinje Cells/cytology
Czasopismo naukowe
Tytuł :
Nox4 regulates InsP 3 receptor-dependent Ca release into mitochondria to promote cell survival.
Autorzy :
Beretta M; School of Cardiovascular Medicine & Sciences, King's College London British Heart Foundation Centre, London, UK.
Santos CX; School of Cardiovascular Medicine & Sciences, King's College London British Heart Foundation Centre, London, UK.
Molenaar C; School of Cardiovascular Medicine & Sciences, King's College London British Heart Foundation Centre, London, UK.
Hafstad AD; School of Cardiovascular Medicine & Sciences, King's College London British Heart Foundation Centre, London, UK.; Cardiovascular Research Group, Department of Medical Biology, UIT-The Arctic University of Norway, Tromsø, Norway.
Miller CC; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Revazian A; Institute for Cardiovascular Physiology, Georg August University Göttingen, Göttingen, Germany.
Betteridge K; School of Cardiovascular Medicine & Sciences, King's College London British Heart Foundation Centre, London, UK.
Schröder K; Institute for Cardiovascular Physiology, Goethe-University Frankfurt, Frankfurt am Main, Germany.
Streckfuß-Bömeke K; Department of Cardiology and Pneumology, Universitätsmedizin Göttingen, Göttingen, Germany.
Doroshow JH; Division of Cancer Treatment and Diagnosis, National Cancer Institute, NIH, Bethesda, MD, USA.
Fleck RA; Centre for Ultrastructural Imaging, King's College London, London, UK.
Su TP; Cellular Pathobiology Section, National Institute on Drug Abuse, NIH, Baltimore, MD, USA.
Belousov VV; Institute for Cardiovascular Physiology, Georg August University Göttingen, Göttingen, Germany.; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia.; Pirogov Russian National Research Medical University, Moscow, Russia.
Parsons M; King's College London British Heart Foundation Centre, Randall Centre of Cell and Molecular Biophysics, London, UK.
Shah AM; School of Cardiovascular Medicine & Sciences, King's College London British Heart Foundation Centre, London, UK.
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Źródło :
The EMBO journal [EMBO J] 2020 Oct 01; Vol. 39 (19), pp. e103530. Date of Electronic Publication: 2020 Aug 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium Signaling*
Calcium/*metabolism
Inositol 1,4,5-Trisphosphate Receptors/*metabolism
Mitochondria, Heart/*metabolism
Myocytes, Cardiac/*metabolism
NADPH Oxidase 4/*metabolism
Animals ; Cell Survival ; Inositol 1,4,5-Trisphosphate Receptors/genetics ; Myocardial Reperfusion Injury/genetics ; Myocardial Reperfusion Injury/metabolism ; NADPH Oxidase 4/genetics ; Oxidative Stress ; Rats
Czasopismo naukowe
Tytuł :
Both d- and l-Glucose Polyphosphates Mimic d- myo -Inositol 1,4,5-Trisphosphate: New Synthetic Agonists and Partial Agonists at the Ins(1,4,5)P 3 Receptor.
Autorzy :
Shipton ML; Drug Discovery & Medicinal Chemistry, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, U. K.
Riley AM; Drug Discovery & Medicinal Chemistry, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, U. K.
Rossi AM; Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, U. K.
Brearley CA; School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, U. K.
Taylor CW; Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, U. K.
Potter BVL; Drug Discovery & Medicinal Chemistry, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, U. K.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 May 28; Vol. 63 (10), pp. 5442-5457. Date of Electronic Publication: 2020 May 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Partial Agonism*
Glucose/*chemistry
Inositol 1,4,5-Trisphosphate/*chemistry
Inositol 1,4,5-Trisphosphate Receptors/*agonists
Inositol 1,4,5-Trisphosphate Receptors/*chemistry
Molecular Mimicry/*drug effects
Polyphosphates/*chemistry
Animals ; Dose-Response Relationship, Drug ; Glucose/pharmacology ; HEK293 Cells ; Humans ; Inositol 1,4,5-Trisphosphate/pharmacology ; Molecular Docking Simulation/methods ; Molecular Mimicry/physiology ; Polyphosphates/pharmacology ; Protein Structure, Secondary ; Rats ; Rats, Wistar
Czasopismo naukowe

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