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Wyszukujesz frazę ""INTERLEUKIN-2"" wg kryterium: Temat


Tytuł :
An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism.
Autorzy :
Ptacin JL; Synthorx, Inc., a Sanofi Company, La Jolla, CA, USA. .
Caffaro CE; Synthorx, Inc., a Sanofi Company, La Jolla, CA, USA.
Ma L; Synthorx, Inc., a Sanofi Company, La Jolla, CA, USA.
San Jose Gall KM; Synthorx, Inc., a Sanofi Company, La Jolla, CA, USA.
Aerni HR; Synthorx, Inc., a Sanofi Company, La Jolla, CA, USA.
Acuff NV; Synthorx, Inc., a Sanofi Company, La Jolla, CA, USA.
Herman RW; Synthorx, Inc., a Sanofi Company, La Jolla, CA, USA.
Pavlova Y; Synthorx, Inc., a Sanofi Company, La Jolla, CA, USA.
Pena MJ; Synthorx, Inc., a Sanofi Company, La Jolla, CA, USA.
Chen DB; Synthorx, Inc., a Sanofi Company, La Jolla, CA, USA.
Koriazova LK; Synthorx, Inc., a Sanofi Company, La Jolla, CA, USA.
Shawver LK; Synthorx, Inc., a Sanofi Company, La Jolla, CA, USA.
Joseph IB; Synthorx, Inc., a Sanofi Company, La Jolla, CA, USA.
Milla ME; Synthorx, Inc., a Sanofi Company, La Jolla, CA, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Aug 09; Vol. 12 (1), pp. 4785. Date of Electronic Publication: 2021 Aug 09.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*therapeutic use
Interleukin-2/*chemistry
Interleukin-2/*metabolism
Interleukin-2/*pharmacology
Animals ; CD8-Positive T-Lymphocytes/drug effects ; CD8-Positive T-Lymphocytes/immunology ; Drug Discovery ; Genetic Engineering ; Humans ; Interleukin-2/genetics ; Interleukin-2 Receptor alpha Subunit ; Killer Cells, Natural/drug effects ; Killer Cells, Natural/immunology ; Lymphocytes/drug effects ; Mice ; Synthetic Biology
Czasopismo naukowe
Tytuł :
Crystal structure of human interleukin-2 in complex with TCB2, a new antibody-drug candidate with antitumor activity.
Autorzy :
Kim J; Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Gyeongbuk, Republic of Korea.
Lee JY; Selecxine, Bio Open Innovation Center #1204, Pohang, Gyeongbuk, Republic of Korea.
Park SY; Pohang Accelerator Laboratory, Pohang University of Science and Technology, Pohang, Republic of Korea.
Lee YJ; Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Gyeongbuk, Republic of Korea.
Kim MS; Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Gyeongbuk, Republic of Korea.
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Źródło :
Oncoimmunology [Oncoimmunology] 2021 Mar 16; Vol. 10 (1), pp. 1899671. Date of Electronic Publication: 2021 Mar 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Interleukin-2*
Pharmaceutical Preparations*
Antibodies ; Humans ; Immunotherapy ; Receptors, Interleukin-2
Czasopismo naukowe
Tytuł :
Differential Effects of IL2Rα and IL15Rα over the Stability of the Common Beta-Gamma Signaling Subunits of the IL2 and IL15 Receptors.
Autorzy :
Ponce LF; Molecular System Biology Department, Center of Molecular Immunology, Havana, Havana 11600, Cuba.; Center for Molecular Simulations, Biological Science Department, University of Calgary, Calgary, Alberta, Canada T2N 1N4.
Montalvo G; Molecular System Biology Department, Center of Molecular Immunology, Havana, Havana 11600, Cuba.
Leon K; Molecular System Biology Department, Center of Molecular Immunology, Havana, Havana 11600, Cuba.
Valiente PA; Center for Protein Studies, Faculty of Biology, University of Havana, Havana, Havana 10400, Cuba.
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Źródło :
Journal of chemical information and modeling [J Chem Inf Model] 2021 Apr 26; Vol. 61 (4), pp. 1913-1920. Date of Electronic Publication: 2021 Mar 25.
Typ publikacji :
Journal Article
MeSH Terms :
Interleukin-15 Receptor alpha Subunit*
Interleukin-2*
Interleukin Receptor Common gamma Subunit/genetics ; Interleukin-15 ; Interleukin-2 Receptor alpha Subunit ; Signal Transduction
Czasopismo naukowe
Tytuł :
Persistent IL-2 Receptor Signaling by IL-2/CD25 Fusion Protein Controls Diabetes in NOD Mice by Multiple Mechanisms.
Autorzy :
Ward NC; Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL.
Lui JB; Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL.
Hernandez R; Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL.
Yu L; Barbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine, Aurora, CO.
Struthers M; Immunology Discovery, Bristol-Myers Squibb, Princeton, NJ.
Xie J; Immunology Discovery, Bristol-Myers Squibb, Princeton, NJ.
Santos Savio A; Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL.
Dwyer CJ; Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL.
Hsiung S; Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL.
Yu A; Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL.
Malek TR; Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL .
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Źródło :
Diabetes [Diabetes] 2020 Nov; Vol. 69 (11), pp. 2400-2413. Date of Electronic Publication: 2020 Aug 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Interleukin-2 Receptor alpha Subunit*
Diabetes Mellitus/*metabolism
Interleukin-2/*pharmacology
Receptors, Interleukin-2/*metabolism
Signal Transduction/*physiology
Animals ; Autoantibodies ; Female ; Humans ; Interleukin-2/chemistry ; Mice ; Mice, Inbred Strains ; Recombinant Fusion Proteins/pharmacology ; T-Lymphocyte Subsets/drug effects
Czasopismo naukowe
Tytuł :
A distal Foxp3 enhancer enables interleukin-2 dependent thymic Treg cell lineage commitment for robust immune tolerance.
Autorzy :
Dikiy S; Howard Hughes Medical Institute and Immunology Program, Ludwig Center at Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10021, USA.
Li J; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Bai L; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Jiang M; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Janke L; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Zong X; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Hao X; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Hoyos B; Howard Hughes Medical Institute and Immunology Program, Ludwig Center at Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Wang ZM; Howard Hughes Medical Institute and Immunology Program, Ludwig Center at Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Gerstner Sloan Kettering Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Xu B; Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Fan Y; Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Rudensky AY; Howard Hughes Medical Institute and Immunology Program, Ludwig Center at Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: .
Feng Y; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address: .
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Źródło :
Immunity [Immunity] 2021 May 11; Vol. 54 (5), pp. 931-946.e11. Date of Electronic Publication: 2021 Apr 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cell Lineage/*immunology
Forkhead Transcription Factors/*immunology
Immune Tolerance/*immunology
Interleukin-2/*immunology
T-Lymphocytes, Regulatory/*immunology
Animals ; Autoimmunity/immunology ; Cell Differentiation/immunology ; Enhancer Elements, Genetic/immunology ; Female ; Humans ; Interleukin-2 Receptor alpha Subunit/immunology ; Male ; Mice ; Receptors, Interleukin-2/immunology ; STAT5 Transcription Factor/immunology ; Signal Transduction/immunology
Czasopismo naukowe
Tytuł :
Receptor-gated IL-2 delivery by an anti-human IL-2 antibody activates regulatory T cells in three different species.
Autorzy :
Karakus U; Department of Immunology, University Hospital Zurich, CH-8091 Zurich, Switzerland.
Sahin D; Department of Immunology, University Hospital Zurich, CH-8091 Zurich, Switzerland.
Mittl PRE; Department of Biochemistry, University of Zurich, CH-8057 Zurich, Switzerland.
Mooij P; Department of Virology, Biomedical Primate Research Centre, 2288 GJ Rijswijk, Netherlands.
Koopman G; Department of Virology, Biomedical Primate Research Centre, 2288 GJ Rijswijk, Netherlands.
Boyman O; Department of Immunology, University Hospital Zurich, CH-8091 Zurich, Switzerland. .; Faculty of Medicine, University of Zurich, CH-8006 Zurich, Switzerland.
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Źródło :
Science translational medicine [Sci Transl Med] 2020 Dec 16; Vol. 12 (574).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Interleukin-2*
T-Lymphocytes, Regulatory*
Animals ; Autoimmunity ; Interleukin-2 Receptor alpha Subunit ; Macaca mulatta ; Mice ; Signal Transduction
Czasopismo naukowe
Tytuł :
Exploring the Pathogenic Role and Therapeutic Implications of Interleukin 2 in Autoimmune Hepatitis.
Autorzy :
Czaja AJ; Professor Emeritus of Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine and Science, 200 First Street S.W., Rochester, MN, 55905, USA. .
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Źródło :
Digestive diseases and sciences [Dig Dis Sci] 2021 Aug; Vol. 66 (8), pp. 2493-2512. Date of Electronic Publication: 2020 Aug 24.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Hepatitis, Autoimmune/*metabolism
Interleukin-2/*metabolism
Receptors, Interleukin-2/*metabolism
Gene Expression Regulation ; Hepatitis, Autoimmune/therapy ; Humans ; Interleukin-2/genetics ; Interleukin-2/therapeutic use ; Lymphocyte Subsets/drug effects ; Lymphocyte Subsets/physiology ; Receptors, Interleukin-2/genetics
Czasopismo naukowe
Tytuł :
CD122-Selective IL2 Complexes Reduce Immunosuppression, Promote Treg Fragility, and Sensitize Tumor Response to PD-L1 Blockade.
Autorzy :
Drerup JM; Department of Cell Systems and Anatomy, The Graduate School of Biomedical Sciences, University of Texas Health San Antonio, Texas.; Department of Medicine, University of Texas Health San Antonio, Texas.
Deng Y; Department of Medicine, University of Texas Health San Antonio, Texas.
Pandeswara SL; Department of Medicine, University of Texas Health San Antonio, Texas.
Padrón ÁS; Department of Medicine, University of Texas Health San Antonio, Texas.
Reyes RM; Department of Microbiology, Immunology and Molecular Genetics, The Graduate School of Biomedical Sciences, University of Texas Health San Antonio, Texas.
Zhang X; Sun Yat-sen University, Guangzhou, Guangdong, P.R.China.
Mendez J; Department of Medicine, University of Texas Health San Antonio, Texas.
Liu A; Department of Medicine, University of Texas Health San Antonio, Texas.
Clark CA; Department of Medicine, University of Texas Health San Antonio, Texas.; Department of Microbiology, Immunology and Molecular Genetics, The Graduate School of Biomedical Sciences, University of Texas Health San Antonio, Texas.
Chen W; Xiangya Medical School, Changsha, Hunan, China.
Conejo-Garcia JR; Department of Immunology, Moffitt Cancer Center, Tampa, Florida.
Hurez V; Department of Medicine, University of Texas Health San Antonio, Texas.
Gupta H; Department of Medicine, University of Texas Health San Antonio, Texas.
Curiel TJ; Department of Medicine, University of Texas Health San Antonio, Texas. .; Department of Microbiology, Immunology and Molecular Genetics, The Graduate School of Biomedical Sciences, University of Texas Health San Antonio, Texas.; Mays Family Cancer Center, University of Texas Health San Antonio, Texas.
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Źródło :
Cancer research [Cancer Res] 2020 Nov 15; Vol. 80 (22), pp. 5063-5075. Date of Electronic Publication: 2020 Sep 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
B7-H1 Antigen/*antagonists & inhibitors
Immunotherapy/*methods
Interleukin-2/*pharmacology
Interleukin-2 Receptor beta Subunit/*antagonists & inhibitors
Melanoma, Experimental/*therapy
Ovarian Neoplasms/*therapy
T-Lymphocytes, Regulatory/*cytology
Animals ; Ascites/immunology ; CD8-Positive T-Lymphocytes/cytology ; CD8-Positive T-Lymphocytes/immunology ; Female ; Immune Tolerance ; Immunity, Cellular ; Immunologic Memory ; Interleukin-2 Receptor beta Subunit/immunology ; Melanoma, Experimental/immunology ; Mice ; Mice, Inbred C57BL ; Ovarian Neoplasms/immunology ; Phenotype ; Random Allocation ; Receptors, Interleukin-2/metabolism ; T-Lymphocyte Subsets/metabolism ; T-Lymphocytes, Regulatory/immunology ; Tumor Microenvironment/immunology
Czasopismo naukowe
Tytuł :
Antitumor Effect of IL-2 and TRAIL Proteins Expressed by Recombinant Salmonella in Murine Bladder Cancer Cells.
Autorzy :
de Lima Fragelli BD; Laboratório de Inflamação e Doenças Infecciosas, Departamento de Morfologia e Patologia, Universidade Federal de São Carlos, São Carlos, Brazil, .
Camillo L; Laboratório de Inflamação e Doenças Infecciosas, Departamento de Morfologia e Patologia, Universidade Federal de São Carlos, São Carlos, Brazil.
de Almeida Rodolpho JM; Laboratório de Inflamação e Doenças Infecciosas, Departamento de Morfologia e Patologia, Universidade Federal de São Carlos, São Carlos, Brazil.
de Godoy KF; Laboratório de Inflamação e Doenças Infecciosas, Departamento de Morfologia e Patologia, Universidade Federal de São Carlos, São Carlos, Brazil.
de Castro CA; Laboratório de Inflamação e Doenças Infecciosas, Departamento de Morfologia e Patologia, Universidade Federal de São Carlos, São Carlos, Brazil.
Brassolatti P; Laboratório de Inflamação e Doenças Infecciosas, Departamento de Morfologia e Patologia, Universidade Federal de São Carlos, São Carlos, Brazil.
da Silva AJ; Laboratório de Fábrica Celular, Departamento de Engenharia Química, Universidade Federal de São Carlos, São Carlos, Brazil.
Borra RC; Laboratório de Imunologia Aplicada, Departamento de Genética e Evolução, Universidade Federal de São Carlos, São Carlos, Brazil.
de Freitas Anibal F; Laboratório de Inflamação e Doenças Infecciosas, Departamento de Morfologia e Patologia, Universidade Federal de São Carlos, São Carlos, Brazil.
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Źródło :
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology [Cell Physiol Biochem] 2021 Aug 07; Vol. 55 (4), pp. 460-476.
Typ publikacji :
Journal Article
MeSH Terms :
Interleukin-2/*immunology
Microorganisms, Genetically-Modified/*immunology
Salmonella/*immunology
TNF-Related Apoptosis-Inducing Ligand/*immunology
Urinary Bladder Neoplasms/*immunology
Urinary Bladder Neoplasms/*therapy
Animals ; Cell Line, Tumor ; Interleukin-2/biosynthesis ; Interleukin-2/genetics ; Mice ; Microorganisms, Genetically-Modified/genetics ; Microorganisms, Genetically-Modified/metabolism ; Salmonella/genetics ; Salmonella/metabolism ; TNF-Related Apoptosis-Inducing Ligand/biosynthesis ; TNF-Related Apoptosis-Inducing Ligand/genetics ; Urinary Bladder Neoplasms/genetics ; Urinary Bladder Neoplasms/metabolism
Czasopismo naukowe
Tytuł :
Biomarkers of systemic inflammation, soluble IL-2Rα and the multiple sclerosis-associated IL2RA SNP rs2104286 in healthy subjects and multiple sclerosis patients.
Autorzy :
Buhelt S; Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Glostrup, Denmark. Electronic address: .
Søndergaard HB; Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Glostrup, Denmark.
Mahler MR; Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Glostrup, Denmark.
Cobanovic S; Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Glostrup, Denmark.
Börnsen L; Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Glostrup, Denmark.
Ammitzbøll C; Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Glostrup, Denmark.
Oturai AB; Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Glostrup, Denmark.
Sellebjerg F; Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Glostrup, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
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Źródło :
Multiple sclerosis and related disorders [Mult Scler Relat Disord] 2021 Sep; Vol. 54, pp. 103140. Date of Electronic Publication: 2021 Jul 07.
Typ publikacji :
Journal Article
MeSH Terms :
Interleukin-2 Receptor alpha Subunit*/genetics
Multiple Sclerosis*/genetics
Biomarkers ; Healthy Volunteers ; Humans ; Inflammation/genetics ; Polymorphism, Single Nucleotide
Czasopismo naukowe
Tytuł :
Evaluation of the level of serum Interleukins (IL-2, IL-4, IL-15 andIL-17) and its relationship with disease severity in patients with alopecia areata.
Autorzy :
Aşkın Ö; Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey.
Yücesoy SN; Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey. Electronic address: .
Coşkun E; Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey.
Engin B; Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey.
Serdaroğlu S; Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey.
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Źródło :
Anais brasileiros de dermatologia [An Bras Dermatol] 2021 Sep-Oct; Vol. 96 (5), pp. 551-557. Date of Electronic Publication: 2021 Jul 17.
Typ publikacji :
Journal Article
MeSH Terms :
Alopecia Areata*/drug therapy
Interleukin-2*
Adolescent ; Humans ; Interleukin-15 ; Interleukin-17 ; Interleukin-4 ; Interleukins ; Severity of Illness Index
Czasopismo naukowe
Tytuł :
Faster speed of onset of the depressive episode is associated with lower cytokine serum levels (IL-2, -4, -6, -10, TNF-α and IFN-γ) in patients with major depression.
Autorzy :
Buspavanich P; Department of Psychiatry and Psychotherapy, Charité -Universitätmedizin Berlin, Campus Mitte, Berlin, Germany; Department of Psychiatry, Psychotherapy and Psychosomatics, Brandenburg Medical School Theodor Fontane, Neuruppin, Germany.
Adli M; Department of Psychiatry and Psychotherapy, Charité -Universitätmedizin Berlin, Campus Mitte, Berlin, Germany; Department of Psychiatry and Psychotherapy, Fliedner Klinik Berlin, Berlin, Germany.
Himmerich H; Department of Psychological Medicine, King's College London, London, United Kingdom; Department of Psychiatry and Psychotherapy, University of Leipzig, Leipzig, Germany.
Berger M; Department of Psychiatry and Psychotherapy, Charité -Universitätmedizin Berlin, Campus Mitte, Berlin, Germany; Department of Psychiatry, Psychotherapy and Psychosomatics, Brandenburg Medical School Theodor Fontane, Neuruppin, Germany.
Busche M; Department of Psychiatry and Psychotherapy, Charité -Universitätmedizin Berlin, Campus Mitte, Berlin, Germany.
Schlattmann P; Department of Statistics, Informatics and Data Science, Jena University Hospital, Jena, Germany.
Bopp S; Department of Psychiatry and Psychotherapy, Charité -Universitätmedizin Berlin, Campus Mitte, Berlin, Germany.
Bschor T; Department of Psychiatry and Psychotherapy, Technical University of Dresden Medical School, Dresden, Germany.
Richter C; Department of Psychiatry and Psychotherapy, Charité -Universitätmedizin Berlin, Campus Mitte, Berlin, Germany; Department of Psychiatry and Psychotherapy, Vivantes Klinikum Kaulsdorf, Berlin, Germany.
Steinacher B; Department of Psychiatry and Psychotherapy, Vivantes Wenckebach-Klinikum, Berlin, Germany; Department of Psychiatry and Psychotherapy, Vivantes Auguste-Viktoria-Klinikum, Berlin, Germany.
Stoppel C; Department of Psychiatry and Psychotherapy, Vivantes Auguste-Viktoria-Klinikum, Berlin, Germany.
Hindinger C; Department of Psychiatry, Psychotherapy and Psychosomatics, Brandenburg Medical School Theodor Fontane, Neuruppin, Germany.
Meyer S; Department of Psychiatry and Psychotherapy, Charité -Universitätmedizin Berlin, Campus Mitte, Berlin, Germany.
Hoffmann K; Department of Psychiatry and Psychotherapy, Charité -Universitätmedizin Berlin, Campus Mitte, Berlin, Germany.
Stamm T; Department of Psychiatry and Psychotherapy, Charité -Universitätmedizin Berlin, Campus Mitte, Berlin, Germany; Department of Psychiatry, Psychotherapy and Psychosomatics, Brandenburg Medical School Theodor Fontane, Neuruppin, Germany.
Gabriel A; Department of Psychiatry, Psychotherapy and Psychosomatics, Brandenburg Medical School Theodor Fontane, Neuruppin, Germany.
Merkl A; Department of Psychiatry and Psychotherapy, Charité -Universitätmedizin Berlin, Campus Mitte, Berlin, Germany; Department of Psychiatry and Psychotherapy, Fliedner Klinik Berlin, Berlin, Germany.
Goerke-Arndt F; Department of Psychiatry and Psychotherapy, Oberhavel-Kliniken, Henningsdorf, Germany.
Köhler S; Department of Psychiatry and Psychotherapy, Charité -Universitätmedizin Berlin, Campus Mitte, Berlin, Germany.
Sterzer P; Department of Psychiatry and Psychotherapy, Charité -Universitätmedizin Berlin, Campus Mitte, Berlin, Germany.
Heinz A; Department of Psychiatry and Psychotherapy, Charité -Universitätmedizin Berlin, Campus Mitte, Berlin, Germany.
Behr J; Department of Psychiatry, Psychotherapy and Psychosomatics, Brandenburg Medical School Theodor Fontane, Neuruppin, Germany; Faculty of Health Sciences Brandenburg, Joint Faculty of the University of Potsdam, Brandenburg University of Technology Cottbus-Senftenberg and Brandenburg Medical School, Potsdam, Germany; Research Department of Experimental and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Campus Mitte, Germany.
Fakhri H; Department of Physiology, University of Tübingen, Tübingen, Germany.
Lang F; Department of Physiology, University of Tübingen, Tübingen, Germany.
Lang UE; Department of Psychiatry and Psychotherapy, University Psychiatric Clinics, Basel, Switzerland.
Ricken R; Department of Psychiatry and Psychotherapy, Charité -Universitätmedizin Berlin, Campus Mitte, Berlin, Germany. Electronic address: .
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Źródło :
Journal of psychiatric research [J Psychiatr Res] 2021 Sep; Vol. 141, pp. 287-292. Date of Electronic Publication: 2021 Jul 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Depressive Disorder, Major*
Interleukin-2*
Cytokines ; Depression ; Humans ; Interferon-gamma ; Retrospective Studies ; Tumor Necrosis Factor-alpha
Czasopismo naukowe
Tytuł :
Drug-induced liver injury and prospect of cytokine based therapy; A focus on IL-2 based therapies.
Autorzy :
Kumar N; Irma Lerma Rangel College of Pharmacy, Texas A&M University System, Kingsville, TX 78363, United States of America. Electronic address: .
Surani S; Irma Lerma Rangel College of Pharmacy, Texas A&M University System, Kingsville, TX 78363, United States of America.
Udeani G; Irma Lerma Rangel College of Pharmacy, Texas A&M University System, Kingsville, TX 78363, United States of America.
Mathew S; Irma Lerma Rangel College of Pharmacy, Texas A&M University System, Kingsville, TX 78363, United States of America.
John S; Irma Lerma Rangel College of Pharmacy, Texas A&M University System, Kingsville, TX 78363, United States of America.
Sajan S; Irma Lerma Rangel College of Pharmacy, Texas A&M University System, Kingsville, TX 78363, United States of America.
Mishra J; Irma Lerma Rangel College of Pharmacy, Texas A&M University System, Kingsville, TX 78363, United States of America. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Aug 01; Vol. 278, pp. 119544. Date of Electronic Publication: 2021 May 01.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Chemical and Drug Induced Liver Injury/*drug therapy
Cytokines/*therapeutic use
Interleukin-2/*therapeutic use
Liver/*drug effects
Analgesics, Non-Narcotic/adverse effects ; Animals ; Chemical and Drug Induced Liver Injury/pathology ; Cytokines/pharmacology ; Humans ; Inflammation/drug therapy ; Inflammation/pathology ; Interleukin-2/pharmacology ; Liver/pathology
Czasopismo naukowe
Tytuł :
T cell signaling and Treg dysfunction correlate to disease kinetics in IL-2Rα-KO autoimmune mice.
Autorzy :
Mullins GN; Quantitative and Systems Biology Graduate Program, University of California Merced, Merced, CA, 95343, USA.; Health Sciences Research Institute, University of California Merced, Merced, CA, 95343, USA.
Valentine KM; Quantitative and Systems Biology Graduate Program, University of California Merced, Merced, CA, 95343, USA.; Health Sciences Research Institute, University of California Merced, Merced, CA, 95343, USA.
Al-Kuhlani M; Department of Molecular and Cell Biology, School of Natural Sciences, University of California Merced, Merced, CA, 95343, USA.
Davini D; Department of Molecular and Cell Biology, School of Natural Sciences, University of California Merced, Merced, CA, 95343, USA.
Jensen KDC; Quantitative and Systems Biology Graduate Program, University of California Merced, Merced, CA, 95343, USA.; Department of Molecular and Cell Biology, School of Natural Sciences, University of California Merced, Merced, CA, 95343, USA.; Health Sciences Research Institute, University of California Merced, Merced, CA, 95343, USA.
Hoyer KK; Quantitative and Systems Biology Graduate Program, University of California Merced, Merced, CA, 95343, USA. .; Department of Molecular and Cell Biology, School of Natural Sciences, University of California Merced, Merced, CA, 95343, USA. .; Health Sciences Research Institute, University of California Merced, Merced, CA, 95343, USA. .
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Źródło :
Scientific reports [Sci Rep] 2020 Dec 15; Vol. 10 (1), pp. 21994. Date of Electronic Publication: 2020 Dec 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Signal Transduction*
Interleukin-2 Receptor alpha Subunit/*deficiency
T-Lymphocytes, Regulatory/*immunology
Animals ; Apoptosis ; CD8-Positive T-Lymphocytes/immunology ; Cell Proliferation ; Erythrocytes/metabolism ; Immunologic Memory ; Interleukin-2/metabolism ; Interleukin-2 Receptor alpha Subunit/metabolism ; Kinetics ; Lymphocyte Activation/immunology ; Mice, Inbred BALB C ; Mice, Knockout ; Thymus Gland/growth & development
Czasopismo naukowe
Tytuł :
IL-2 enhances ex vivo-expanded regulatory T-cell persistence after adoptive transfer.
Autorzy :
Furlan SN; Fred Hutchinson Cancer Research Center and Department of Pediatrics, University of Washington, Seattle, WA.
Singh K; Cincinnati Children's Hospital, Cincinnati, OH.
Lopez C; Seattle Children's Research Institute and Department of Pediatrics, University of Washington, Seattle, WA.
Tkachev V; Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA.
Hunt DJ; Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA.
Hibbard J; Seattle Children's Research Institute and Department of Pediatrics, University of Washington, Seattle, WA.
Betz KM; Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA.
Blazar BR; Division of Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, MN; and.
Trapnell C; Department of Genome Sciences, University of Washington, Seattle, WA.
Kean LS; Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA.
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Źródło :
Blood advances [Blood Adv] 2020 Apr 28; Vol. 4 (8), pp. 1594-1605.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Interleukin-2*
T-Lymphocytes, Regulatory*
Adoptive Transfer ; Animals ; Interleukin-2 Receptor alpha Subunit ; Sirolimus/pharmacology
Czasopismo naukowe
Tytuł :
Overproduction of IL-2 by Cbl-b deficient CD4 T cells provides resistance against regulatory T cells.
Autorzy :
Han S; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Department of Immunology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Chung DC; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Department of Immunology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
St Paul M; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Department of Immunology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Liu ZQ; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Department of Immunology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Garcia-Batres C; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Elford AR; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Tran CW; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Department of Immunology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Chapatte L; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Ohashi PS; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Department of Immunology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
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Źródło :
Oncoimmunology [Oncoimmunology] 2020 Apr 07; Vol. 9 (1), pp. 1737368. Date of Electronic Publication: 2020 Apr 07 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Interleukin-2*/genetics
T-Lymphocytes, Regulatory*/metabolism
Animals ; Interleukin-2 Receptor alpha Subunit ; Mice, Inbred C57BL ; Signal Transduction ; Ubiquitin-Protein Ligases/metabolism
Czasopismo naukowe
Tytuł :
Phase II study of E7777 in Japanese patients with relapsed/refractory peripheral and cutaneous T-cell lymphoma.
Autorzy :
Kawai H; Department of Hematology and Oncology, Tokai University School of Medicine, Isehara, Japan.
Ando K; Department of Hematology and Oncology, Tokai University School of Medicine, Isehara, Japan.
Maruyama D; Department of Hematology, National Cancer Center Hospital, National Cancer Center Hospital, Tokyo, Japan.
Yamamoto K; Department of Hematology and Cell Therapy, Aichi Cancer Center, Nagoya, Japan.
Kiyohara E; Department of Dermatology, Osaka University Hospital, Osaka, Japan.
Terui Y; Department of Hematology Oncology, The Cancer Institute Hospital of JFCR, Tokyo, Japan.
Fukuhara N; Department of Hematology and Rheumatology, Tohoku University Hospital, Sendai, Japan.
Miyagaki T; Department of Dermatology, The University of Tokyo Hospital, Tokyo, Japan.
Tokura Y; Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Sakata-Yanagimoto M; Department of Hematology, University of Tsukuba Hospital, Tsukuba, Japan.
Igarashi T; Department of Hematology, Gunma Cancer Center, Ota, Japan.
Kuroda J; Division of Hematology and Oncology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Fujita J; Department of Dermatology, Osaka University Hospital, Osaka, Japan.
Uchida T; Department of Hematology and Oncology, Japanese Red Cross Nagoya Daini Hospital, Nagoya, Japan.
Ishikawa T; Department of Hematology, Kobe City Medical Center General Hospital, Kobe, Japan.
Yonekura K; Department of Dermatology, Imamura General Hospital, Kagoshima, Japan.
Kato K; Department of Hematology and Oncology, Kyushu University Hospital, Fukuoka, Japan.
Nakanishi T; Eisai Co., Ltd., Tokyo, Japan.
Nakai K; Eisai Co., Ltd., Tokyo, Japan.
Matsunaga R; Eisai Co., Ltd., Tokyo, Japan.
Tobinai K; Department of Hematology, National Cancer Center Hospital, National Cancer Center Hospital, Tokyo, Japan.
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Źródło :
Cancer science [Cancer Sci] 2021 Jun; Vol. 112 (6), pp. 2426-2435. Date of Electronic Publication: 2021 May 03.
Typ publikacji :
Clinical Trial, Phase II; Journal Article; Multicenter Study
MeSH Terms :
Interleukin-2/*administration & dosage
Lymphoma, T-Cell, Cutaneous/*drug therapy
Lymphoma, T-Cell, Peripheral/*drug therapy
Neoplasm Recurrence, Local/*drug therapy
Recombinant Fusion Proteins/*administration & dosage
Administration, Intravenous ; Binding Sites ; Diphtheria Toxin/administration & dosage ; Diphtheria Toxin/adverse effects ; Diphtheria Toxin/chemistry ; Diphtheria Toxin/genetics ; Diphtheria Toxin/pharmacokinetics ; Drug Administration Schedule ; Female ; Humans ; Interleukin-2/adverse effects ; Interleukin-2/chemistry ; Interleukin-2/genetics ; Interleukin-2/pharmacokinetics ; Japan ; Lymphoma, T-Cell, Cutaneous/blood ; Lymphoma, T-Cell, Peripheral/blood ; Male ; Neoplasm Recurrence, Local/blood ; Recombinant Fusion Proteins/adverse effects ; Recombinant Fusion Proteins/pharmacokinetics ; Survival Analysis ; Treatment Outcome
Czasopismo naukowe
Tytuł :
PRDM1 decreases sensitivity of human NK cells to IL2-induced cell expansion by directly repressing CD25 (IL2RA).
Autorzy :
Akman B; İzmir International Biomedicine and Genome Institute (iBG-izmir), Dokuz Eylül University (DEU), İzmir, Turkey.; İzmir Biomedicine and Genome Center (IBG), İzmir, Turkey.
Hu X; İzmir International Biomedicine and Genome Institute (iBG-izmir), Dokuz Eylül University (DEU), İzmir, Turkey.
Liu X; Department of Pathology, City of Hope, Duarte, California, USA.
Hatipoğlu T; İzmir International Biomedicine and Genome Institute (iBG-izmir), Dokuz Eylül University (DEU), İzmir, Turkey.; İzmir Biomedicine and Genome Center (IBG), İzmir, Turkey.
You H; Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, China.
Chan WC; Department of Pathology, City of Hope, Duarte, California, USA.
Küçük C; İzmir International Biomedicine and Genome Institute (iBG-izmir), Dokuz Eylül University (DEU), İzmir, Turkey.; İzmir Biomedicine and Genome Center (IBG), İzmir, Turkey.; Department of Medical Biology, Faculty of Medicine, Dokuz Eylül University, İzmir, Turkey.
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Źródło :
Journal of leukocyte biology [J Leukoc Biol] 2021 May; Vol. 109 (5), pp. 901-914. Date of Electronic Publication: 2020 Nov 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Interleukin-2/*metabolism
Interleukin-2 Receptor alpha Subunit/*metabolism
Killer Cells, Natural/*cytology
Killer Cells, Natural/*metabolism
Positive Regulatory Domain I-Binding Factor 1/*metabolism
Cell Line ; Cell Proliferation ; Down-Regulation/genetics ; Female ; Humans ; Interleukin-2 Receptor alpha Subunit/genetics ; Introns/genetics ; Lymphocyte Activation/immunology ; Male ; Protein Binding ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Up-Regulation
Czasopismo naukowe
Tytuł :
Zinc deficiency leads to reduced interleukin-2 production by active gene silencing due to enhanced CREMα expression in T cells.
Autorzy :
Kloubert V; Institute of Immunology, Faculty of Medicine, RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany.
Wessels I; Institute of Immunology, Faculty of Medicine, RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany.
Wolf J; Institute of Immunology, Faculty of Medicine, RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany.
Blaabjerg K; Department of Animal Science - Animal Nutrition and Physiology, Aarhus University/Foulum, Blichers Allé 20, 8830, Tjele, Denmark.
Janssens V; Laboratory of Protein Phosphorylation & Proteomics, Department of Cellular and Molecular Medicine, Faculty of Medicine, KU Leuven & LKI (Leuven Cancer Institute, KU Leuven), Leuven, Belgium.
Hapala J; Helmholtz Institute for Biomedical Engineering, Stem Cell Biology and Cellular Engineering, RWTH Aachen University, Pauwelsstr. 20, 52074, Aachen, Germany; Institute of Biomedical Engineering, Department of Cell Biology, Faculty of Medicine, RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany.
Wagner W; Helmholtz Institute for Biomedical Engineering, Stem Cell Biology and Cellular Engineering, RWTH Aachen University, Pauwelsstr. 20, 52074, Aachen, Germany; Institute of Biomedical Engineering, Department of Cell Biology, Faculty of Medicine, RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany.
Rink L; Institute of Immunology, Faculty of Medicine, RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany. Electronic address: .
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Źródło :
Clinical nutrition (Edinburgh, Scotland) [Clin Nutr] 2021 May; Vol. 40 (5), pp. 3263-3278. Date of Electronic Publication: 2020 Oct 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Silencing*
Cyclic AMP Response Element Modulator/*immunology
Gene Expression/*genetics
Interleukin-2/*biosynthesis
T-Lymphocytes/*immunology
Zinc/*deficiency
Zinc/*immunology
Animals ; Cyclic AMP Response Element Modulator/genetics ; Disease Models, Animal ; Gene Expression/immunology ; Humans ; In Vitro Techniques ; Interleukin-2/genetics ; Interleukin-2/immunology ; Swine
Czasopismo naukowe
Tytuł :
Potential contribution of increased soluble IL-2R to lymphopenia in COVID-19 patients.
Autorzy :
Zhang Y; State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, 320 Yueyang Road, 200031, Shanghai, China.
Wang X; Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China.
Li X; State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, 320 Yueyang Road, 200031, Shanghai, China.
Xi D; Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China.
Mao R; Clinical Research Center and Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 200030, Shanghai, China.
Wu X; Clinical Research Center and Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 200030, Shanghai, China.
Cheng S; State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, 320 Yueyang Road, 200031, Shanghai, China.
Sun X; State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, 320 Yueyang Road, 200031, Shanghai, China.
Yi C; State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, 320 Yueyang Road, 200031, Shanghai, China.
Ling Z; State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, 320 Yueyang Road, 200031, Shanghai, China.
Ma L; State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, 320 Yueyang Road, 200031, Shanghai, China.
Ning Q; Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China.
Fang Y; Clinical Research Center and Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 200030, Shanghai, China. .
Sun B; State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, 320 Yueyang Road, 200031, Shanghai, China. .
Wu D; Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China. .
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Źródło :
Cellular & molecular immunology [Cell Mol Immunol] 2020 Aug; Vol. 17 (8), pp. 878-880. Date of Electronic Publication: 2020 Jun 25.
Typ publikacji :
Journal Article
MeSH Terms :
Betacoronavirus*
Lymphopenia*
Coronavirus Infections/*blood
Coronavirus Infections/*immunology
Interleukin Receptor Common gamma Subunit/*blood
Interleukin-2 Receptor alpha Subunit/*blood
Interleukin-2 Receptor beta Subunit/*blood
Pneumonia, Viral/*blood
Pneumonia, Viral/*immunology
B-Lymphocytes/immunology ; COVID-19 ; Coronavirus Infections/virology ; HLA-DR Antigens/metabolism ; Healthy Volunteers ; Humans ; Interleukin-2/metabolism ; Pandemics ; Pneumonia, Viral/virology ; SARS-CoV-2 ; Solubility ; T-Lymphocytes/immunology
Czasopismo naukowe

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