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    Tytuł:
    Pancreatic cancer stem cells may define tumor stroma characteristics and recurrence patterns in pancreatic ductal adenocarcinoma.
    Autorzy:
    Askan G; Memorial Sloan Kettering Cancer Center, 300 East 66th street, office 1021, New York, NY, 10065, USA.
    Sahin IH; H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA.
    Chou JF; Memorial Sloan Kettering Cancer Center, 300 East 66th street, office 1021, New York, NY, 10065, USA.
    Yavas A; Memorial Sloan Kettering Cancer Center, 300 East 66th street, office 1021, New York, NY, 10065, USA.
    Capanu M; Memorial Sloan Kettering Cancer Center, 300 East 66th street, office 1021, New York, NY, 10065, USA.
    Iacobuzio-Donahue CA; Memorial Sloan Kettering Cancer Center, 300 East 66th street, office 1021, New York, NY, 10065, USA.; David M. Rubenstein Center for Pancreatic Cancer, New York, USA.
    Basturk O; Memorial Sloan Kettering Cancer Center, 300 East 66th street, office 1021, New York, NY, 10065, USA.; David M. Rubenstein Center for Pancreatic Cancer, New York, USA.
    O'Reilly EM; Memorial Sloan Kettering Cancer Center, 300 East 66th street, office 1021, New York, NY, 10065, USA. .; David M. Rubenstein Center for Pancreatic Cancer, New York, USA. .; Weill Cornell Medical College, New York, USA. .
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    Źródło:
    BMC cancer [BMC Cancer] 2021 Apr 09; Vol. 21 (1), pp. 385. Date of Electronic Publication: 2021 Apr 09.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Cancer-Associated Fibroblasts/*metabolism
    Carcinoma, Pancreatic Ductal/*metabolism
    Carcinoma, Pancreatic Ductal/*pathology
    Neoplastic Stem Cells/*metabolism
    Pancreatic Neoplasms/*metabolism
    Pancreatic Neoplasms/*pathology
    Stromal Cells/*metabolism
    Biomarkers ; Cancer-Associated Fibroblasts/pathology ; Carcinoma, Pancreatic Ductal/mortality ; Carcinoma, Pancreatic Ductal/therapy ; Combined Modality Therapy ; Female ; Humans ; Immunohistochemistry ; Male ; Neoplasm Grading ; Neoplasm Metastasis ; Neoplasm Staging ; Neoplastic Stem Cells/pathology ; Pancreatic Neoplasms/mortality ; Pancreatic Neoplasms/therapy ; Prognosis ; Recurrence ; Stromal Cells/pathology ; Treatment Outcome ; Tumor Microenvironment
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Promoter methylation of ADAMTS1 and BNC1 as potential biomarkers for early detection of pancreatic cancer in blood.
    Autorzy:
    Eissa MAL; Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    Lerner L; Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    Abdelfatah E; Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    Shankar N; Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    Canner JK; Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    Hasan NM; Department of Surgery, Yale-New Haven Health, Yale University, School of Medicine, P.O. Box 208062, New Haven, CT, 06520-8062, USA.
    Yaghoobi V; Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    Huang B; Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    Kerner Z; Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    Takaesu F; Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    Wolfgang C; Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    Kwak R; Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    Ruiz M; Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    Tam M; Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    Pisanic TR 2nd; Johns Hopkins Institute for NanoBioTechnology, The Johns Hopkins University, Baltimore, MD, USA.
    Iacobuzio-Donahue CA; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, USA.; Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    Hruban RH; Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.; The Sol Goldman Pancreatic Cancer Research Center, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Hospital, Baltimore, MD, USA.
    He J; Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    Wang TH; Johns Hopkins Institute for NanoBioTechnology, The Johns Hopkins University, Baltimore, MD, USA.
    Wood LD; Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.; The Sol Goldman Pancreatic Cancer Research Center, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Hospital, Baltimore, MD, USA.
    Sharma A; Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Surgery, Yale-New Haven Health, Yale University, School of Medicine, P.O. Box 208062, New Haven, CT, 06520-8062, USA.
    Ahuja N; Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. .; Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. .; The Sol Goldman Pancreatic Cancer Research Center, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Hospital, Baltimore, MD, USA. .; Department of Surgery, Yale-New Haven Health, Yale University, School of Medicine, P.O. Box 208062, New Haven, CT, 06520-8062, USA. .
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    Źródło:
    Clinical epigenetics [Clin Epigenetics] 2019 Apr 05; Vol. 11 (1), pp. 59. Date of Electronic Publication: 2019 Apr 05.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural
    MeSH Terms:
    DNA Methylation*
    ADAMTS1 Protein/*genetics
    DNA-Binding Proteins/*genetics
    Pancreatic Neoplasms/*diagnosis
    Transcription Factors/*genetics
    Biomarkers, Tumor/blood ; Biomarkers, Tumor/genetics ; Cell-Free Nucleic Acids/genetics ; Early Detection of Cancer ; Epigenesis, Genetic ; Female ; Humans ; Male ; Neoplasm Staging ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/pathology ; Promoter Regions, Genetic ; Sensitivity and Specificity
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Minimal functional driver gene heterogeneity among untreated metastases.
    Autorzy:
    Reiter JG; Canary Center for Cancer Early Detection, Department of Radiology, Stanford University School of Medicine, Palo Alto, CA 94305, USA. _.; Program for Evolutionary Dynamics, Harvard University, Cambridge, MA 02138, USA.
    Makohon-Moore AP; The David M. Rubenstein Center for Pancreatic Cancer Research, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
    Gerold JM; Program for Evolutionary Dynamics, Harvard University, Cambridge, MA 02138, USA.
    Heyde A; Program for Evolutionary Dynamics, Harvard University, Cambridge, MA 02138, USA.
    Attiyeh MA; The David M. Rubenstein Center for Pancreatic Cancer Research, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
    Kohutek ZA; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
    Tokheim CJ; Department of Biomedical Engineering, Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD 21218, USA.
    Brown A; The David M. Rubenstein Center for Pancreatic Cancer Research, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
    DeBlasio RM; The David M. Rubenstein Center for Pancreatic Cancer Research, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
    Niyazov J; The David M. Rubenstein Center for Pancreatic Cancer Research, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
    Zucker A; The David M. Rubenstein Center for Pancreatic Cancer Research, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
    Karchin R; Department of Biomedical Engineering, Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD 21218, USA.; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
    Kinzler KW; The Ludwig Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Sidney Kimmel Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
    Iacobuzio-Donahue CA; The David M. Rubenstein Center for Pancreatic Cancer Research, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
    Vogelstein B; The Ludwig Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Sidney Kimmel Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
    Nowak MA; Program for Evolutionary Dynamics, Harvard University, Cambridge, MA 02138, USA. _.; Department of Organismic and Evolutionary Biology and Department of Mathematics, Harvard University, Cambridge, MA 02138, USA.
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    Źródło:
    Science (New York, N.Y.) [Science] 2018 Sep 07; Vol. 361 (6406), pp. 1033-1037.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms:
    Genetic Heterogeneity*
    Neoplasm Metastasis/*drug therapy
    Neoplasm Metastasis/*genetics
    Neoplasms/*drug therapy
    Neoplasms/*genetics
    Humans ; Models, Theoretical ; Mutation ; Neoplasm Metastasis/pathology ; Neoplasms/pathology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Unresolved endoplasmic reticulum stress engenders immune-resistant, latent pancreatic cancer metastases.
    Autorzy:
    Pommier A; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
    Anaparthy N; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.; Department of Molecular and Cellular Biology, Stony Brook University, Stony Brook, NY 11794, USA.
    Memos N; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
    Kelley ZL; Weill Cornell Medicine, New York, NY 10065, USA.
    Gouronnec A; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
    Yan R; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
    Auffray C; Institut Cochin, Paris Descartes Université, CNRS UMR8104, INSERM U1016, 75014 Paris, France.
    Albrengues J; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
    Egeblad M; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
    Iacobuzio-Donahue CA; Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
    Lyons SK; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
    Fearon DT; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA. .; Weill Cornell Medicine, New York, NY 10065, USA.; Cancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge CB2 0RE, UK.
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    Źródło:
    Science (New York, N.Y.) [Science] 2018 Jun 15; Vol. 360 (6394). Date of Electronic Publication: 2018 May 17.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Tumor Escape*
    Carcinoma, Pancreatic Ductal/*secondary
    Endoplasmic Reticulum Stress/*immunology
    Liver Neoplasms/*secondary
    Pancreatic Neoplasms/*pathology
    Animals ; Carcinoma, Pancreatic Ductal/immunology ; Endoribonucleases/genetics ; Endoribonucleases/metabolism ; Genes, MHC Class I ; Genetic Engineering ; Humans ; Keratin-19/metabolism ; Liver Neoplasms/immunology ; Lymphocyte Depletion ; Mice ; Mice, Inbred C57BL ; Neoplasms, Experimental/genetics ; Neoplasms, Experimental/immunology ; Neoplasms, Experimental/secondary ; Pancreatic Neoplasms/immunology ; Protein Serine-Threonine Kinases/genetics ; Protein Serine-Threonine Kinases/metabolism ; T-Lymphocytes/immunology ; X-Box Binding Protein 1/genetics ; X-Box Binding Protein 1/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma.
    Autorzy:
    Moffitt RA; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA.
    Marayati R; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA.
    Flate EL; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA.
    Volmar KE; University of North Carolina-Rex Healthcare, Chapel Hill, North Carolina, USA.
    Loeza SG; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA.
    Hoadley KA; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA.; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA.
    Rashid NU; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA.
    Williams LA; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA.; Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA.
    Eaton SC; Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina, USA.
    Chung AH; Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina, USA.
    Smyla JK; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA.
    Anderson JM; Eppley Cancer Institute, University of Nebraska, Lincoln, Nebraska, USA.
    Kim HJ; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA.; Department of Surgery, University of North Carolina, Chapel Hill, North Carolina, USA.
    Bentrem DJ; Department of Surgery, Feinberg School of Medicine Northwestern University, Chicago, Illinois, USA.; Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine Northwestern University, Chicago, Illinois, USA.
    Talamonti MS; Department of Surgery, NorthShore University HealthSystem, Evanston, Illinois, USA.
    Iacobuzio-Donahue CA; Department of Pathology, David Rubenstein Center for Pancreatic Cancer Research, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
    Hollingsworth MA; Eppley Cancer Institute, University of Nebraska, Lincoln, Nebraska, USA.
    Yeh JJ; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA.; Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina, USA.; Department of Surgery, University of North Carolina, Chapel Hill, North Carolina, USA.
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    Źródło:
    Nature genetics [Nat Genet] 2015 Oct; Vol. 47 (10), pp. 1168-78. Date of Electronic Publication: 2015 Sep 07.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Adenocarcinoma/*pathology
    Carcinoma, Pancreatic Ductal/*pathology
    Pancreatic Neoplasms/*pathology
    Stromal Cells/*pathology
    Adenocarcinoma/genetics ; Animals ; Carcinoma, Pancreatic Ductal/genetics ; Female ; Gene Expression ; Genetic Heterogeneity ; Heterografts ; Humans ; Male ; Pancreatic Neoplasms/genetics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Retrotransposon insertions in the clonal evolution of pancreatic ductal adenocarcinoma.
    Autorzy:
    Rodić N; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
    Steranka JP; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
    Makohon-Moore A; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
    Moyer A; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
    Shen P; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
    Sharma R; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
    Kohutek ZA; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
    Huang CR; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
    Ahn D; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
    Mita P; Department of Molecular Biology &Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; High Throughput (HiT) Biology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
    Taylor MS; High Throughput (HiT) Biology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
    Barker NJ; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
    Hruban RH; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Hospital, Baltimore, Maryland, USA.; The Sol Goldman Center for Pancreatic Cancer Research, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
    Iacobuzio-Donahue CA; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Hospital, Baltimore, Maryland, USA.; The Sol Goldman Center for Pancreatic Cancer Research, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
    Boeke JD; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Molecular Biology &Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; High Throughput (HiT) Biology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Hospital, Baltimore, Maryland, USA.; Institute for Systems Genetics, New York University Langone School of Medicine, New York, New York, USA.
    Burns KH; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; High Throughput (HiT) Biology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Hospital, Baltimore, Maryland, USA.
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    Źródło:
    Nature medicine [Nat Med] 2015 Sep; Vol. 21 (9), pp. 1060-4. Date of Electronic Publication: 2015 Aug 10.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms:
    Clonal Evolution*
    Carcinoma, Pancreatic Ductal/*genetics
    Long Interspersed Nucleotide Elements/*physiology
    Pancreatic Neoplasms/*genetics
    Apoptotic Protease-Activating Factor 1/analysis ; Humans
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Whole genomes redefine the mutational landscape of pancreatic cancer.
    Autorzy:
    Waddell N; 1] Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia [2] QIMR Berghofer Medical Research Institute, Herston Road, Brisbane 4006, Australia.
    Pajic M; 1] The Kinghorn Cancer Centre, Cancer Division, Garvan Institute of Medical Research, University of New South Wales, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia [2] St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, New South Wales 2010, Australia.
    Patch AM; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.
    Chang DK; 1] The Kinghorn Cancer Centre, Cancer Division, Garvan Institute of Medical Research, University of New South Wales, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia [2] Department of Surgery, Bankstown Hospital, Eldridge Road, Bankstown, Sydney, New South Wales 2200, Australia [3] South Western Sydney Clinical School, Faculty of Medicine, University of New South Wales, Liverpool, New South Wales 2170, Australia [4] Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK.
    Kassahn KS; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.
    Bailey P; 1] Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia [2] Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK.
    Johns AL; The Kinghorn Cancer Centre, Cancer Division, Garvan Institute of Medical Research, University of New South Wales, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia.
    Miller D; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.
    Nones K; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.
    Quek K; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.
    Quinn MC; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.
    Robertson AJ; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.
    Fadlullah MZ; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.
    Bruxner TJ; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.
    Christ AN; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.
    Harliwong I; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.
    Idrisoglu S; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.
    Manning S; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.
    Nourse C; 1] Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia [2] Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK.
    Nourbakhsh E; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.
    Wani S; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.
    Wilson PJ; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.
    Markham E; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.
    Cloonan N; 1] Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia [2] QIMR Berghofer Medical Research Institute, Herston Road, Brisbane 4006, Australia.
    Anderson MJ; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.
    Fink JL; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.
    Holmes O; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.
    Kazakoff SH; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.
    Leonard C; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.
    Newell F; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.
    Poudel B; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.
    Song S; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.
    Taylor D; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.
    Waddell N; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.
    Wood S; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.
    Xu Q; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.
    Wu J; The Kinghorn Cancer Centre, Cancer Division, Garvan Institute of Medical Research, University of New South Wales, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia.
    Pinese M; The Kinghorn Cancer Centre, Cancer Division, Garvan Institute of Medical Research, University of New South Wales, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia.
    Cowley MJ; The Kinghorn Cancer Centre, Cancer Division, Garvan Institute of Medical Research, University of New South Wales, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia.
    Lee HC; The Kinghorn Cancer Centre, Cancer Division, Garvan Institute of Medical Research, University of New South Wales, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia.
    Jones MD; 1] The Kinghorn Cancer Centre, Cancer Division, Garvan Institute of Medical Research, University of New South Wales, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia [2] Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK.
    Nagrial AM; The Kinghorn Cancer Centre, Cancer Division, Garvan Institute of Medical Research, University of New South Wales, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia.
    Humphris J; The Kinghorn Cancer Centre, Cancer Division, Garvan Institute of Medical Research, University of New South Wales, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia.
    Chantrill LA; The Kinghorn Cancer Centre, Cancer Division, Garvan Institute of Medical Research, University of New South Wales, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia.
    Chin V; The Kinghorn Cancer Centre, Cancer Division, Garvan Institute of Medical Research, University of New South Wales, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia.
    Steinmann AM; The Kinghorn Cancer Centre, Cancer Division, Garvan Institute of Medical Research, University of New South Wales, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia.
    Mawson A; The Kinghorn Cancer Centre, Cancer Division, Garvan Institute of Medical Research, University of New South Wales, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia.
    Humphrey ES; The Kinghorn Cancer Centre, Cancer Division, Garvan Institute of Medical Research, University of New South Wales, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia.
    Colvin EK; The Kinghorn Cancer Centre, Cancer Division, Garvan Institute of Medical Research, University of New South Wales, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia.
    Chou A; 1] The Kinghorn Cancer Centre, Cancer Division, Garvan Institute of Medical Research, University of New South Wales, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia [2] Department of Anatomical Pathology, St Vincent's Hospital, Sydney, New South Wales 2010, Australia.
    Scarlett CJ; 1] The Kinghorn Cancer Centre, Cancer Division, Garvan Institute of Medical Research, University of New South Wales, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia [2] School of Environmental &Life Sciences, University of Newcastle, Ourimbah, New South Wales 2258, Australia.
    Pinho AV; The Kinghorn Cancer Centre, Cancer Division, Garvan Institute of Medical Research, University of New South Wales, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia.
    Giry-Laterriere M; The Kinghorn Cancer Centre, Cancer Division, Garvan Institute of Medical Research, University of New South Wales, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia.
    Rooman I; The Kinghorn Cancer Centre, Cancer Division, Garvan Institute of Medical Research, University of New South Wales, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia.
    Samra JS; 1] Department of Surgery, Royal North Shore Hospital, St Leonards, Sydney, New South Wales 2065, Australia [2] University of Sydney, Sydney, New South Wales 2006, Australia.
    Kench JG; 1] The Kinghorn Cancer Centre, Cancer Division, Garvan Institute of Medical Research, University of New South Wales, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia [2] University of Sydney, Sydney, New South Wales 2006, Australia [3] Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Camperdown, New South Wales 2050, Australia.
    Pettitt JA; The Kinghorn Cancer Centre, Cancer Division, Garvan Institute of Medical Research, University of New South Wales, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia.
    Merrett ND; 1] Department of Surgery, Bankstown Hospital, Eldridge Road, Bankstown, Sydney, New South Wales 2200, Australia [2] School of Medicine, University of Western Sydney, Penrith, New South Wales 2175, Australia.
    Toon C; The Kinghorn Cancer Centre, Cancer Division, Garvan Institute of Medical Research, University of New South Wales, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia.
    Epari K; Department of Surgery, Fremantle Hospital, Alma Street, Fremantle, Western Australia 6160, Australia.
    Nguyen NQ; Department of Gastroenterology, Royal Adelaide Hospital, North Terrace, Adelaide, South Australia 5000, Australia.
    Barbour A; Department of Surgery, Princess Alexandra Hospital, Ipswich Rd, Woollongabba, Queensland 4102, Australia.
    Zeps N; 1] School of Surgery M507, University of Western Australia, 35 Stirling Highway, Nedlands 6009, Australia [2] St John of God Pathology, 12 Salvado Rd, Subiaco, Western Australia 6008, Australia [3] Bendat Family Comprehensive Cancer Centre, St John of God Subiaco Hospital, Subiaco, Western Australia 6008, Australia.
    Jamieson NB; 1] Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK [2] Academic Unit of Surgery, School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow Royal Infirmary, Glasgow G4 OSF, UK [3] West of Scotland Pancreatic Unit, Glasgow Royal Infirmary, Glasgow G31 2ER, UK.
    Graham JS; 1] Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK [2] Department of Medical Oncology, Beatson West of Scotland Cancer Centre, 1053 Great Western Road, Glasgow G12 0YN, UK.
    Niclou SP; Norlux Neuro-Oncology Laboratory, CRP-Santé Luxembourg, 84 Val Fleuri, L-1526, Luxembourg.
    Bjerkvig R; Norlux Neuro-Oncology, Department of Biomedicine, University of Bergen, Jonas Lies vei 91, N-5019 Bergen, Norway.
    Grützmann R; Departments of Surgery and Pathology, TU Dresden, Fetscherstr. 74, 01307 Dresden, Germany.
    Aust D; Departments of Surgery and Pathology, TU Dresden, Fetscherstr. 74, 01307 Dresden, Germany.
    Hruban RH; Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, the Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.
    Maitra A; Departments of Pathology and Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston Texas 77030, USA.
    Iacobuzio-Donahue CA; The David M. Rubenstein Pancreatic Cancer Research Center and Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
    Wolfgang CL; Department of Surgery, The Sol Goldman Pancreatic Cancer Research Center, the Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.
    Morgan RA; Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, the Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.
    Lawlor RT; 1] ARC-NET Centre for Applied Research on Cancer, University and Hospital Trust of Verona, Verona 37134, Italy [2] Department of Pathology and Diagnostics, University of Verona, Verona 37134, Italy.
    Corbo V; ARC-NET Centre for Applied Research on Cancer, University and Hospital Trust of Verona, Verona 37134, Italy.
    Bassi C; Department of Surgery and Oncology, Pancreas Institute, University and Hospital Trust of Verona, Verona 37134, Italy.
    Falconi M; 1] Department of Surgery and Oncology, Pancreas Institute, University and Hospital Trust of Verona, Verona 37134, Italy [2] Departments of Surgery and Pathology, Ospedale Sacro Cuore Don Calabria Negrar, Verona 37024, Italy.
    Zamboni G; 1] Department of Pathology and Diagnostics, University of Verona, Verona 37134, Italy [2] Departments of Surgery and Pathology, Ospedale Sacro Cuore Don Calabria Negrar, Verona 37024, Italy.
    Tortora G; Department of Oncology, University and Hospital Trust of Verona, Verona 37134, Italy.
    Tempero MA; Division of Hematology and Oncology, University of California, San Francisco, California 94122, USA.
    Gill AJ; 1] The Kinghorn Cancer Centre, Cancer Division, Garvan Institute of Medical Research, University of New South Wales, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia [2] University of Sydney, Sydney, New South Wales 2006, Australia.
    Eshleman JR; Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, the Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.
    Pilarsky C; Departments of Surgery and Pathology, TU Dresden, Fetscherstr. 74, 01307 Dresden, Germany.
    Scarpa A; 1] ARC-NET Centre for Applied Research on Cancer, University and Hospital Trust of Verona, Verona 37134, Italy [2] Department of Pathology and Diagnostics, University of Verona, Verona 37134, Italy.
    Musgrove EA; Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK.
    Pearson JV; 1] Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia [2] QIMR Berghofer Medical Research Institute, Herston Road, Brisbane 4006, Australia.
    Biankin AV; 1] The Kinghorn Cancer Centre, Cancer Division, Garvan Institute of Medical Research, University of New South Wales, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia [2] Department of Surgery, Bankstown Hospital, Eldridge Road, Bankstown, Sydney, New South Wales 2200, Australia [3] South Western Sydney Clinical School, Faculty of Medicine, University of New South Wales, Liverpool, New South Wales 2170, Australia [4] Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK.
    Grimmond SM; 1] Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia [2] Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK.
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    Corporate Authors:
    Australian Pancreatic Cancer Genome Initiative
    Źródło:
    Nature [Nature] 2015 Feb 26; Vol. 518 (7540), pp. 495-501.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    DNA Mutational Analysis*
    Genomics*
    Genome, Human/*genetics
    Mutation/*genetics
    Pancreatic Neoplasms/*genetics
    Adenocarcinoma/drug therapy ; Adenocarcinoma/genetics ; Animals ; Carcinoma, Pancreatic Ductal/drug therapy ; Carcinoma, Pancreatic Ductal/genetics ; DNA Repair/genetics ; Female ; Genes, BRCA1 ; Genes, BRCA2 ; Genetic Markers/genetics ; Genomic Instability/genetics ; Genotype ; Humans ; Mice ; Pancreatic Neoplasms/classification ; Pancreatic Neoplasms/drug therapy ; Platinum/pharmacology ; Point Mutation/genetics ; Poly(ADP-ribose) Polymerase Inhibitors ; Xenograft Model Antitumor Assays
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    A draft map of the human proteome.
    Autorzy:
    Kim MS; 1] McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA [2] Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
    Pinto SM; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
    Getnet D; 1] McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA [2] Adrienne Helis Malvin Medical Research Foundation, New Orleans, Louisiana 70130, USA.
    Nirujogi RS; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
    Manda SS; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
    Chaerkady R; 1] McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA [2] Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
    Madugundu AK; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
    Kelkar DS; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
    Isserlin R; The Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada.
    Jain S; The Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada.
    Thomas JK; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
    Muthusamy B; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
    Leal-Rojas P; 1] McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA [2] Department of Pathology, Universidad de La Frontera, Center of Genetic and Immunological Studies-Scientific and Technological Bioresource Nucleus, Temuco 4811230, Chile.
    Kumar P; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
    Sahasrabuddhe NA; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
    Balakrishnan L; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
    Advani J; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
    George B; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
    Renuse S; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
    Selvan LD; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
    Patil AH; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
    Nanjappa V; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
    Radhakrishnan A; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
    Prasad S; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
    Subbannayya T; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
    Raju R; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
    Kumar M; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
    Sreenivasamurthy SK; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
    Marimuthu A; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
    Sathe GJ; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
    Chavan S; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
    Datta KK; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
    Subbannayya Y; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
    Sahu A; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
    Yelamanchi SD; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
    Jayaram S; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
    Rajagopalan P; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
    Sharma J; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
    Murthy KR; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
    Syed N; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
    Goel R; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
    Khan AA; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
    Ahmad S; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
    Dey G; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
    Mudgal K; School of Medicine, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.
    Chatterjee A; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
    Huang TC; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
    Zhong J; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
    Wu X; 1] McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA [2] Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
    Shaw PG; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
    Freed D; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
    Zahari MS; Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
    Mukherjee KK; Department of Neurosurgery, Postgraduate Institute of Medical Education & Research, Chandigarh 160012, India.
    Shankar S; Department of Internal Medicine Armed Forces Medical College, Pune 411040, India.
    Mahadevan A; 1] Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore 560029, India [2] Human Brain Tissue Repository, Neurobiology Research Centre, National Institute of Mental Health and Neurosciences, Bangalore 560029, India.
    Lam H; Department of Chemical and Biomolecular Engineering and Division of Biomedical Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong.
    Mitchell CJ; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
    Shankar SK; 1] Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore 560029, India [2] Human Brain Tissue Repository, Neurobiology Research Centre, National Institute of Mental Health and Neurosciences, Bangalore 560029, India.
    Satishchandra P; Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore 560029, India.
    Schroeder JT; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA.
    Sirdeshmukh R; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
    Maitra A; 1] The Sol Goldman Pancreatic Cancer Research Center, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA [2] Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.
    Leach SD; 1] McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA [2] Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.
    Drake CG; 1] Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA [2] Departments of Immunology and Urology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.
    Halushka MK; The Sol Goldman Pancreatic Cancer Research Center, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.
    Prasad TS; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
    Hruban RH; 1] The Sol Goldman Pancreatic Cancer Research Center, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA [2] Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.
    Kerr CL; 1] Department of Obstetrics and Gynecology, Johns Hopkins University School of Medicine Baltimore, Maryland 21205, USA [2] Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
    Bader GD; The Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada.
    Iacobuzio-Donahue CA; 1] The Sol Goldman Pancreatic Cancer Research Center, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA [2] Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA [3] Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.
    Gowda H; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
    Pandey A; 1] McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA [2] Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA [3] Institute of Bioinformatics, International Tech Park, Bangalore 560066, India [4] Adrienne Helis Malvin Medical Research Foundation, New Orleans, Louisiana 70130, USA [5] The Sol Goldman Pancreatic Cancer Research Center, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA [6] Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA [7] Diana Helis Henry Medical Research Foundation, New Orleans, Louisiana 70130, USA.
    Pokaż więcej
    Źródło:
    Nature [Nature] 2014 May 29; Vol. 509 (7502), pp. 575-81.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Proteomics*
    Proteome/*metabolism
    Adult ; Cells, Cultured ; Databases, Protein ; Fetus/metabolism ; Fourier Analysis ; Gene Expression Profiling ; Genome, Human/genetics ; Hematopoietic Stem Cells/cytology ; Hematopoietic Stem Cells/metabolism ; Humans ; Internet ; Mass Spectrometry ; Molecular Sequence Annotation ; Open Reading Frames/genetics ; Organ Specificity ; Protein Biosynthesis ; Protein Isoforms/analysis ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Protein Sorting Signals ; Protein Transport ; Proteome/analysis ; Proteome/chemistry ; Proteome/genetics ; Pseudogenes/genetics ; RNA, Untranslated/genetics ; Reproducibility of Results ; Untranslated Regions/genetics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes.
    Autorzy:
    Biankin AV; The Kinghorn Cancer Centre, 370 Victoria Street, Darlinghurst, Sydney, New South Wales 2010, Australia.
    Waddell N
    Kassahn KS
    Gingras MC
    Muthuswamy LB
    Johns AL
    Miller DK
    Wilson PJ
    Patch AM
    Wu J
    Chang DK
    Cowley MJ
    Gardiner BB
    Song S
    Harliwong I
    Idrisoglu S
    Nourse C
    Nourbakhsh E
    Manning S
    Wani S
    Gongora M
    Pajic M
    Scarlett CJ
    Gill AJ
    Pinho AV
    Rooman I
    Anderson M
    Holmes O
    Leonard C
    Taylor D
    Wood S
    Xu Q
    Nones K
    Fink JL
    Christ A
    Bruxner T
    Cloonan N
    Kolle G
    Newell F
    Pinese M
    Mead RS
    Humphris JL
    Kaplan W
    Jones MD
    Colvin EK
    Nagrial AM
    Humphrey ES
    Chou A
    Chin VT
    Chantrill LA
    Mawson A
    Samra JS
    Kench JG
    Lovell JA
    Daly RJ
    Merrett ND
    Toon C
    Epari K
    Nguyen NQ
    Barbour A
    Zeps N
    Kakkar N
    Zhao F
    Wu YQ
    Wang M
    Muzny DM
    Fisher WE
    Brunicardi FC
    Hodges SE
    Reid JG
    Drummond J
    Chang K
    Han Y
    Lewis LR
    Dinh H
    Buhay CJ
    Beck T
    Timms L
    Sam M
    Begley K
    Brown A
    Pai D
    Panchal A
    Buchner N
    De Borja R
    Denroche RE
    Yung CK
    Serra S
    Onetto N
    Mukhopadhyay D
    Tsao MS
    Shaw PA
    Petersen GM
    Gallinger S
    Hruban RH
    Maitra A
    Iacobuzio-Donahue CA
    Schulick RD
    Wolfgang CL
    Morgan RA
    Lawlor RT
    Capelli P
    Corbo V
    Scardoni M
    Tortora G
    Tempero MA
    Mann KM
    Jenkins NA
    Perez-Mancera PA
    Adams DJ
    Largaespada DA
    Wessels LF
    Rust AG
    Stein LD
    Tuveson DA
    Copeland NG
    Musgrove EA
    Scarpa A
    Eshleman JR
    Hudson TJ
    Sutherland RL
    Wheeler DA
    Pearson JV
    McPherson JD
    Gibbs RA
    Grimmond SM
    Pokaż więcej
    Corporate Authors:
    Australian Pancreatic Cancer Genome Initiative
    Źródło:
    Nature [Nature] 2012 Nov 15; Vol. 491 (7424), pp. 399-405. Date of Electronic Publication: 2012 Oct 24.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Axons/*metabolism
    Carcinoma, Pancreatic Ductal/*genetics
    Carcinoma, Pancreatic Ductal/*pathology
    Genome/*genetics
    Pancreatic Neoplasms/*genetics
    Pancreatic Neoplasms/*pathology
    Animals ; Gene Dosage ; Gene Expression Regulation, Neoplastic ; Humans ; Kaplan-Meier Estimate ; Mice ; Mutation ; Proteins/genetics ; Signal Transduction
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    GATA6 activates Wnt signaling in pancreatic cancer by negatively regulating the Wnt antagonist Dickkopf-1.
    Autorzy:
    Zhong Y; Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America.
    Wang Z
    Fu B
    Pan F
    Yachida S
    Dhara M
    Albesiano E
    Li L
    Naito Y
    Vilardell F
    Cummings C
    Martinelli P
    Li A
    Yonescu R
    Ma Q
    Griffin CA
    Real FX
    Iacobuzio-Donahue CA
    Pokaż więcej
    Źródło:
    PloS one [PLoS One] 2011; Vol. 6 (7), pp. e22129. Date of Electronic Publication: 2011 Jul 19.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Signal Transduction*
    GATA6 Transcription Factor/*metabolism
    Intercellular Signaling Peptides and Proteins/*genetics
    Pancreatic Neoplasms/*genetics
    Wnt Proteins/*antagonists & inhibitors
    Wnt Proteins/*metabolism
    Carcinoma in Situ/genetics ; Carcinoma in Situ/pathology ; Carcinoma, Pancreatic Ductal/genetics ; Carcinoma, Pancreatic Ductal/pathology ; Cell Line, Tumor ; Cell Proliferation ; Disease Progression ; Gene Dosage/genetics ; Gene Expression Regulation, Neoplastic ; Gene Knockdown Techniques ; Humans ; Intercellular Signaling Peptides and Proteins/metabolism ; Pancreatic Neoplasms/pathology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Distant metastasis occurs late during the genetic evolution of pancreatic cancer.
    Autorzy:
    Yachida S; Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA.
    Jones S
    Bozic I
    Antal T
    Leary R
    Fu B
    Kamiyama M
    Hruban RH
    Eshleman JR
    Nowak MA
    Velculescu VE
    Kinzler KW
    Vogelstein B
    Iacobuzio-Donahue CA
    Pokaż więcej
    Źródło:
    Nature [Nature] 2010 Oct 28; Vol. 467 (7319), pp. 1114-7.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Disease Progression*
    Evolution, Molecular*
    Mutation/*genetics
    Neoplasm Metastasis/*genetics
    Pancreatic Neoplasms/*genetics
    Pancreatic Neoplasms/*pathology
    Adenocarcinoma/genetics ; Adenocarcinoma/pathology ; Autopsy ; Cell Lineage/genetics ; Clone Cells/metabolism ; Clone Cells/pathology ; DNA Mutational Analysis ; Early Detection of Cancer ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/secondary ; Lung Neoplasms/genetics ; Lung Neoplasms/secondary ; Models, Biological ; Neoplasm Metastasis/pathology ; Pancreas/metabolism ; Pancreas/pathology ; Peritoneal Neoplasms/genetics ; Peritoneal Neoplasms/secondary ; Time Factors
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    A six-gene signature predicts survival of patients with localized pancreatic ductal adenocarcinoma.
    Autorzy:
    Stratford JK; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
    Bentrem DJ
    Anderson JM
    Fan C
    Volmar KA
    Marron JS
    Routh ED
    Caskey LS
    Samuel JC
    Der CJ
    Thorne LB
    Calvo BF
    Kim HJ
    Talamonti MS
    Iacobuzio-Donahue CA
    Hollingsworth MA
    Perou CM
    Yeh JJ
    Pokaż więcej
    Źródło:
    PLoS medicine [PLoS Med] 2010 Jul 13; Vol. 7 (7), pp. e1000307. Date of Electronic Publication: 2010 Jul 13.
    Typ publikacji:
    Evaluation Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Validation Study
    MeSH Terms:
    Gene Expression Profiling*/methods
    Carcinoma, Pancreatic Ductal/*diagnosis
    Carcinoma, Pancreatic Ductal/*mortality
    Pancreatic Neoplasms/*diagnosis
    Pancreatic Neoplasms/*mortality
    Adenocarcinoma/diagnosis ; Adenocarcinoma/genetics ; Adenocarcinoma/mortality ; Adenocarcinoma/pathology ; Carcinoma, Pancreatic Ductal/genetics ; Carcinoma, Pancreatic Ductal/pathology ; Gene Expression Regulation, Neoplastic/physiology ; Humans ; Neoplasm Metastasis ; Neoplasm Staging ; Oligonucleotide Array Sequence Analysis ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/pathology ; Prognosis ; Survival Analysis ; Tissue Array Analysis
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene.
    Autorzy:
    Jones S; Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Baltimore, MD 21231, USA.
    Hruban RH
    Kamiyama M
    Borges M
    Zhang X
    Parsons DW
    Lin JC
    Palmisano E
    Brune K
    Jaffee EM
    Iacobuzio-Donahue CA
    Maitra A
    Parmigiani G
    Kern SE
    Velculescu VE
    Kinzler KW
    Vogelstein B
    Eshleman JR
    Goggins M
    Klein AP
    Pokaż więcej
    Źródło:
    Science (New York, N.Y.) [Science] 2009 Apr 10; Vol. 324 (5924), pp. 217. Date of Electronic Publication: 2009 Mar 05.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Genetic Predisposition to Disease*
    Germ-Line Mutation*
    Nuclear Proteins/*genetics
    Pancreatic Neoplasms/*genetics
    Tumor Suppressor Proteins/*genetics
    Breast Neoplasms/genetics ; Codon, Terminator ; Fanconi Anemia Complementation Group N Protein ; Female ; Humans ; Male ; Pedigree ; Sequence Analysis, DNA ; Sequence Deletion
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    The pathology and genetics of metastatic pancreatic cancer.
    Autorzy:
    Yachida S; The Johns Hopkins Medical Institutions, The Sol Goldman Pancreatic Cancer Research Center, Baltimore, Maryland 21231, USA.
    Iacobuzio-Donahue CA
    Pokaż więcej
    Źródło:
    Archives of pathology & laboratory medicine [Arch Pathol Lab Med] 2009 Mar; Vol. 133 (3), pp. 413-22.
    Typ publikacji:
    Journal Article; Review
    MeSH Terms:
    Neoplasm Metastasis/*genetics
    Neoplasm Metastasis/*pathology
    Pancreatic Neoplasms/*genetics
    Pancreatic Neoplasms/*pathology
    Biomarkers, Tumor/metabolism ; Diagnosis, Differential ; Humans ; Neoplasm Metastasis/diagnosis ; Pancreatic Neoplasms/diagnosis ; Receptor, EphA2/metabolism ; Smad4 Protein/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Loss of imprinting of Igf2 alters intestinal maturation and tumorigenesis in mice.
    Autorzy:
    Sakatani T; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
    Kaneda A
    Iacobuzio-Donahue CA
    Carter MG
    de Boom Witzel S
    Okano H
    Ko MS
    Ohlsson R
    Longo DL
    Feinberg AP
    Pokaż więcej
    Źródło:
    Science (New York, N.Y.) [Science] 2005 Mar 25; Vol. 307 (5717), pp. 1976-8. Date of Electronic Publication: 2005 Feb 24.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
    MeSH Terms:
    Genomic Imprinting*
    Enterocytes/*cytology
    Insulin-Like Growth Factor II/*genetics
    Insulin-Like Growth Factor II/*metabolism
    Intestinal Mucosa/*cytology
    Intestinal Mucosa/*metabolism
    Intestinal Neoplasms/*etiology
    Adenoma/etiology ; Adenoma/pathology ; Animals ; Apoptosis ; Cell Differentiation ; Cell Proliferation ; Colon/cytology ; Colon/metabolism ; Colonic Neoplasms/etiology ; Colonic Neoplasms/pathology ; Enterocytes/metabolism ; Ephrin-B1/analysis ; Epigenesis, Genetic ; Female ; Humans ; Intestinal Neoplasms/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Microfilament Proteins/analysis ; Nerve Tissue Proteins/analysis ; Nuclear Proteins/analysis ; RNA, Long Noncoding ; RNA, Untranslated/genetics ; RNA-Binding Proteins/analysis ; Stem Cells/cytology ; Transcription Factors/analysis ; Twist-Related Protein 1
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Epigenetic inactivation of TFPI-2 as a common mechanism associated with growth and invasion of pancreatic ductal adenocarcinoma.
    Autorzy:
    Sato N; Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA.
    Parker AR
    Fukushima N
    Miyagi Y
    Iacobuzio-Donahue CA
    Eshleman JR
    Goggins M
    Pokaż więcej
    Źródło:
    Oncogene [Oncogene] 2005 Jan 27; Vol. 24 (5), pp. 850-8.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
    MeSH Terms:
    Adenocarcinoma/*genetics
    Azacitidine/*analogs & derivatives
    Azacitidine/*toxicity
    Carcinoma, Pancreatic Ductal/*genetics
    Glycoproteins/*genetics
    Pancreatic Neoplasms/*genetics
    Adenocarcinoma/surgery ; Antimetabolites, Antineoplastic/toxicity ; Base Sequence ; Carcinoma, Pancreatic Ductal/surgery ; Cell Line, Tumor ; DNA Primers ; Decitabine ; Glycoproteins/antagonists & inhibitors ; Humans ; Hydroxamic Acids/toxicity ; Loss of Heterozygosity ; Oligonucleotide Array Sequence Analysis ; Pancreatic Neoplasms/surgery ; Reverse Transcriptase Polymerase Chain Reaction ; Transplantation, Heterologous
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
      Wyświetlanie 1-18 z 18

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