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Wyszukujesz frazę ""Idébénone"" wg kryterium: Temat


Tytuł :
Multifunctional radical quenchers as potential therapeutic agents for the treatment of mitochondrial dysfunction.
Autorzy :
Ji X; Biodesign Center for BioEnergetics, Arizona State University, Tempe, AZ 85287, USA.
Khdour OM; Biodesign Center for BioEnergetics, Arizona State University, Tempe, AZ 85287, USA.
Hecht SM; Biodesign Center for BioEnergetics, Arizona State University, Tempe, AZ 85287, USA.; School of Molecular Sciences, Arizona State University, Tempe, AZ 85287, USA.
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Źródło :
Future medicinal chemistry [Future Med Chem] 2019 Jul; Vol. 11 (13), pp. 1605-1624.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Antioxidants/*pharmacology
Mitochondria/*drug effects
Neurodegenerative Diseases/*drug therapy
Small Molecule Libraries/*pharmacology
Animals ; Antioxidants/chemistry ; Humans ; Mitochondria/metabolism ; Neurodegenerative Diseases/metabolism ; Reactive Oxygen Species/metabolism ; Small Molecule Libraries/chemistry
Czasopismo naukowe
Tytuł :
Leber Hereditary Optic Neuropathy-Light at the End of the Tunnel?
Autorzy :
Kim US; Kim's Eye Hospital, Seoul, South Korea.; Department of Ophthalmology, Konyang University College of Medicine, Daejeon, South Korea.
Jurkute N; NIHR Biomedical Research Centre at Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, United Kingdom.
Yu-Wai-Man P; NIHR Biomedical Research Centre at Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, United Kingdom.; Cambridge Eye Unit, Addenbrooke's Hospital, Cambridge University Hospitals, Cambridge, United Kingdom.; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, United Kingdom.; Cambridge Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.
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Źródło :
Asia-Pacific journal of ophthalmology (Philadelphia, Pa.) [Asia Pac J Ophthalmol (Phila)] 2018 Jul-Aug; Vol. 7 (4), pp. 242-245. Date of Electronic Publication: 2018 Jul 15.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Optic Atrophy, Hereditary, Leber*/diagnosis
Optic Atrophy, Hereditary, Leber*/genetics
Optic Atrophy, Hereditary, Leber*/metabolism
Point Mutation*
DNA, Mitochondrial/*genetics
Mitochondria/*genetics
Retinal Ganglion Cells/*pathology
Humans ; Retinal Ganglion Cells/metabolism
Czasopismo naukowe
Tytuł :
Modulating Mitophagy in Mitochondrial Disease.
Autorzy :
Dombi E; Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford, United Kingdom.
Mortiboys H; Sheffield Institute for Translational Neuroscience, Neuroscience Department, University of Sheffield, United Kingdom.
Poulton J; Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford, United Kingdom.
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Źródło :
Current medicinal chemistry [Curr Med Chem] 2018; Vol. 25 (40), pp. 5597-5612.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Mitochondria/*drug effects
Mitochondria/*pathology
Mitochondrial Diseases/*drug therapy
Mitophagy/*drug effects
Animals ; Autophagy/drug effects ; Humans ; Lysosomes/drug effects ; Lysosomes/metabolism
Czasopismo naukowe
Tytuł :
Targeting mitochondrial function to treat optic neuropathy.
Autorzy :
Gueven N; Pharmacy, School of Medicine, University of Tasmania, Hobart, TAS, Australia. Electronic address: .
Nadikudi M; Pharmacy, School of Medicine, University of Tasmania, Hobart, TAS, Australia.
Daniel A; Pharmacy, School of Medicine, University of Tasmania, Hobart, TAS, Australia.
Chhetri J; Pharmacy, School of Medicine, University of Tasmania, Hobart, TAS, Australia.
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Źródło :
Mitochondrion [Mitochondrion] 2017 Sep; Vol. 36, pp. 7-14. Date of Electronic Publication: 2016 Jul 28.
Typ publikacji :
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms :
Mitochondria/*drug effects
Mitochondria/*physiology
Neuroprotective Agents/*therapeutic use
Optic Nerve Diseases/*drug therapy
Optic Nerve Diseases/*physiopathology
Humans
Czasopismo naukowe
Tytuł :
Mitochondrial biogenesis and neural differentiation of human iPSC is modulated by idebenone in a developmental stage-dependent manner.
Autorzy :
Augustyniak J; Stem Cell Bioengineering Unit, Mossakowski Medical Research Centre Polish Academy of Sciences, Warsaw, Poland.
Lenart J; Department of Neurochemistry, Mossakowski Medical Research Centre Polish Academy of Sciences, Warsaw, Poland.
Zychowicz M; Stem Cell Bioengineering Unit, Mossakowski Medical Research Centre Polish Academy of Sciences, Warsaw, Poland.
Stepien PP; Department of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, Warsaw, Poland.; Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland.; Centre of New Technologies, University of Warsaw, Warsaw, Poland.
Buzanska L; Stem Cell Bioengineering Unit, Mossakowski Medical Research Centre Polish Academy of Sciences, Warsaw, Poland. .
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Źródło :
Biogerontology [Biogerontology] 2017 Aug; Vol. 18 (4), pp. 665-677. Date of Electronic Publication: 2017 Jun 22.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Organelle Biogenesis*
Induced Pluripotent Stem Cells/*drug effects
Mitochondria/*drug effects
Neural Stem Cells/*drug effects
Neurogenesis/*drug effects
Neurons/*drug effects
Ubiquinone/*analogs & derivatives
Biomarkers ; Cell Line ; Cell Lineage ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; DNA, Mitochondrial/genetics ; DNA, Mitochondrial/metabolism ; Dose-Response Relationship, Drug ; Gene Expression Regulation ; Humans ; Induced Pluripotent Stem Cells/metabolism ; Membrane Potential, Mitochondrial/drug effects ; Mitochondria/metabolism ; Neural Stem Cells/metabolism ; Neurons/metabolism ; Phenotype ; Reactive Oxygen Species/metabolism ; Ubiquinone/pharmacology
Czasopismo naukowe
Tytuł :
Human thioredoxin 2 deficiency impairs mitochondrial redox homeostasis and causes early-onset neurodegeneration.
Autorzy :
Holzerova E; 1 Institute of Human Genetics, Technische Universität München, Trogerstr. 32, 81675 Munich, Germany 2 Institute of Human Genetics, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany.
Danhauser K; 3 Department of General Paediatrics, Neonatology and Paediatric Cardiology, University Children's Hospital, Heinrich-Heine-University Düsseldorf, Moorenstr. 5, 40225 Düsseldorf, Germany.
Haack TB; 1 Institute of Human Genetics, Technische Universität München, Trogerstr. 32, 81675 Munich, Germany 2 Institute of Human Genetics, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany.
Kremer LS; 1 Institute of Human Genetics, Technische Universität München, Trogerstr. 32, 81675 Munich, Germany 2 Institute of Human Genetics, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany.
Melcher M; 3 Department of General Paediatrics, Neonatology and Paediatric Cardiology, University Children's Hospital, Heinrich-Heine-University Düsseldorf, Moorenstr. 5, 40225 Düsseldorf, Germany.
Ingold I; 4 Institute of Developmental Genetics, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany.
Kobayashi S; 4 Institute of Developmental Genetics, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany 5 Division of Animal Production, Specialty of Bioproduction Science, The United Graduate School of Agricultural Sciences, Iwate University, Morioka, Iwate 020-8550, Japan.
Terrile C; 2 Institute of Human Genetics, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany.
Wolf P; 2 Institute of Human Genetics, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany.
Schaper J; 6 Medical Faculty, Department of Diagnostic and Interventional Radiology, University Düsseldorf, Moorenstr. 5, 40225 Düsseldorf, Germany.
Mayatepek E; 3 Department of General Paediatrics, Neonatology and Paediatric Cardiology, University Children's Hospital, Heinrich-Heine-University Düsseldorf, Moorenstr. 5, 40225 Düsseldorf, Germany.
Baertling F; 3 Department of General Paediatrics, Neonatology and Paediatric Cardiology, University Children's Hospital, Heinrich-Heine-University Düsseldorf, Moorenstr. 5, 40225 Düsseldorf, Germany.
Friedmann Angeli JP; 4 Institute of Developmental Genetics, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany.
Conrad M; 4 Institute of Developmental Genetics, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany.
Strom TM; 2 Institute of Human Genetics, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany.
Meitinger T; 1 Institute of Human Genetics, Technische Universität München, Trogerstr. 32, 81675 Munich, Germany 2 Institute of Human Genetics, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany 7 Munich Cluster for Systems Neurology (SyNergy), 80336 Munich, Germany.
Prokisch H; 1 Institute of Human Genetics, Technische Universität München, Trogerstr. 32, 81675 Munich, Germany 2 Institute of Human Genetics, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany .
Distelmaier F; 3 Department of General Paediatrics, Neonatology and Paediatric Cardiology, University Children's Hospital, Heinrich-Heine-University Düsseldorf, Moorenstr. 5, 40225 Düsseldorf, Germany .
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Źródło :
Brain : a journal of neurology [Brain] 2016 Feb; Vol. 139 (Pt 2), pp. 346-54. Date of Electronic Publication: 2015 Dec 01.
Typ publikacji :
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Homeostasis/*physiology
Mitochondria/*metabolism
Mitochondrial Proteins/*deficiency
Neurodegenerative Diseases/*diagnosis
Neurodegenerative Diseases/*metabolism
Child ; Humans ; Male ; Mitochondria/genetics ; Mitochondrial Proteins/genetics ; Neurodegenerative Diseases/genetics ; Oxidation-Reduction ; Oxidative Stress/physiology ; Reactive Oxygen Species/metabolism ; Thioredoxins/genetics
Czasopismo naukowe
Tytuł :
Idebenone protects against oxidized low density lipoprotein induced mitochondrial dysfunction in vascular endothelial cells via GSK3β/β-catenin signalling pathways.
Autorzy :
Lin P; Laboratory of Neuromuscular Disorders and Department of Neurology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, China; Key Laboratory for Experimental Teratology of the Ministry of Education, Brain Science Research Institute, Shandong University, Jinan, Shandong 250012, China.
Liu J; Laboratory of Neuromuscular Disorders and Department of Neurology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, China; Department of Neurology, Affiliated Hospital of Weifang Medical University, Weifang, Shandong 261031, China.
Ren M; Department of Neurology, Affiliated Hospital of Weifang Medical University, Weifang, Shandong 261031, China.
Ji K; Laboratory of Neuromuscular Disorders and Department of Neurology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, China.
Li L; Laboratory of Neuromuscular Disorders and Department of Neurology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, China.
Zhang B; Laboratory of Neuromuscular Disorders and Department of Neurology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, China.
Gong Y; Key Laboratory of Experimental Teratology, Ministry of Education and Institute of Molecular Medicine and Genetics, Shandong University School of Medicine, Jinan, Shandong 250012, China.
Yan C; Laboratory of Neuromuscular Disorders and Department of Neurology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, China; Key Laboratory for Experimental Teratology of the Ministry of Education, Brain Science Research Institute, Shandong University, Jinan, Shandong 250012, China. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2015 Sep 25; Vol. 465 (3), pp. 548-55. Date of Electronic Publication: 2015 Aug 15.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Endothelial Cells/*metabolism
Glycogen Synthase Kinase 3/*metabolism
Lipoproteins, LDL/*administration & dosage
Mitochondria/*metabolism
Ubiquinone/*analogs & derivatives
beta Catenin/*metabolism
Antioxidants ; Apoptosis/drug effects ; Apoptosis/physiology ; Cell Survival/drug effects ; Cell Survival/physiology ; Cells, Cultured ; Dose-Response Relationship, Drug ; Endothelial Cells/cytology ; Endothelial Cells/drug effects ; Female ; Glycogen Synthase Kinase 3 beta ; Humans ; Mitochondria/ultrastructure ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Treatment Outcome ; Ubiquinone/administration & dosage
Czasopismo naukowe
Tytuł :
Administration of CoQ10 analogue ameliorates dysfunction of the mitochondrial respiratory chain in a mouse model of Angelman syndrome.
Autorzy :
Llewellyn KJ; Department of Pediatrics, Division of Genetics and Genomics, 2501 Hewitt Hall, University of California-Irvine, Irvine, CA 92697, USA. Electronic address: .
Nalbandian A; Department of Pediatrics, Division of Genetics and Genomics, 2501 Hewitt Hall, University of California-Irvine, Irvine, CA 92697, USA.
Gomez A; Department of Pediatrics, Division of Genetics and Genomics, 2501 Hewitt Hall, University of California-Irvine, Irvine, CA 92697, USA.
Wei D; Department of Anatomy & Neurobiology, Gillespie Hall, University of California-Irvine, Irvine, CA 92697, USA.
Walker N; Department of Pediatrics, Division of Genetics and Genomics, 2501 Hewitt Hall, University of California-Irvine, Irvine, CA 92697, USA.
Kimonis VE; Department of Pediatrics, Division of Genetics and Genomics, 2501 Hewitt Hall, University of California-Irvine, Irvine, CA 92697, USA. Electronic address: .
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Źródło :
Neurobiology of disease [Neurobiol Dis] 2015 Apr; Vol. 76, pp. 77-86. Date of Electronic Publication: 2015 Feb 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Angelman Syndrome/*drug therapy
Angelman Syndrome/*metabolism
Antioxidants/*administration & dosage
Electron Transport/*drug effects
Mitochondria/*drug effects
Mitochondria/*metabolism
Ubiquinone/*analogs & derivatives
Animals ; Cerebellum/drug effects ; Cerebellum/metabolism ; Disease Models, Animal ; Hippocampus/drug effects ; Hippocampus/metabolism ; Mice ; Motor Activity/drug effects ; Oxidative Stress/drug effects ; Ubiquinone/administration & dosage ; Ubiquitin-Protein Ligases/genetics
Czasopismo naukowe
Tytuł :
Border between natural product and drug: comparison of the related benzoquinones idebenone and coenzyme Q10.
Autorzy :
Gueven N; Pharmacy, School of Medicine, University of Tasmania, Hobart, Australia. Electronic address: .
Woolley K; School of Chemistry, University of Tasmania, Hobart, Australia.
Smith J; School of Chemistry, University of Tasmania, Hobart, Australia.
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Źródło :
Redox biology [Redox Biol] 2015; Vol. 4, pp. 289-95. Date of Electronic Publication: 2015 Jan 14.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Antioxidants/*pharmacology
Biological Products/*pharmacology
Electron Transport/*drug effects
Mitochondria/*drug effects
Ubiquinone/*analogs & derivatives
Adenosine Triphosphate/biosynthesis ; Antioxidants/chemistry ; Biological Products/chemistry ; Humans ; Membrane Potential, Mitochondrial/drug effects ; Mitochondria/metabolism ; Molecular Weight ; NAD(P)H Dehydrogenase (Quinone)/metabolism ; Structure-Activity Relationship ; Ubiquinone/chemistry ; Ubiquinone/pharmacology
Czasopismo naukowe
Tytuł :
Therapeutic approaches for the treatment of Friedreich's ataxia.
Autorzy :
Strawser CJ; Department of Neurology, The Children's Hospital of Philadelphia, Abramson Research Center, Room 502, 3615 Civic Center Blvd, Philadelphia, PA, 19104, USA.
Schadt KA
Lynch DR
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Źródło :
Expert review of neurotherapeutics [Expert Rev Neurother] 2014 Aug; Vol. 14 (8), pp. 949-57. Date of Electronic Publication: 2014 Jul 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antioxidants/*therapeutic use
Friedreich Ataxia/*therapy
Mitochondria/*drug effects
Humans ; Mitochondria/metabolism
Czasopismo naukowe

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