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    Wyświetlanie 1-17 z 17
    Tytuł:
    Targeted clearance of p21- but not p16-positive senescent cells prevents radiation-induced osteoporosis and increased marrow adiposity.
    Autorzy:
    Chandra A; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.
    Lagnado AB; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.
    Farr JN; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.; Division of Endocrinology, Mayo Clinic, Rochester, Minnesota, USA.
    Doolittle M; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.; Division of Endocrinology, Mayo Clinic, Rochester, Minnesota, USA.
    Tchkonia T; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.
    Kirkland JL; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.
    LeBrasseur NK; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, Minnesota, USA.
    Robbins PD; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA.
    Niedernhofer LJ; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA.
    Ikeno Y; Department of Pathology and Laboratory Medicine, University of Texas Health Science Center, San Antonio, Texas, USA.
    Passos JF; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.
    Monroe DG; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.; Division of Endocrinology, Mayo Clinic, Rochester, Minnesota, USA.
    Pignolo RJ; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.; Division of Endocrinology, Mayo Clinic, Rochester, Minnesota, USA.
    Khosla S; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.; Division of Endocrinology, Mayo Clinic, Rochester, Minnesota, USA.
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    Źródło:
    Aging cell [Aging Cell] 2022 May; Vol. 21 (5), pp. e13602. Date of Electronic Publication: 2022 Apr 01.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural
    MeSH Terms:
    Cyclin-Dependent Kinase Inhibitor p16*/genetics
    Cyclin-Dependent Kinase Inhibitor p16*/metabolism
    Osteoporosis*/genetics
    Adiposity ; Animals ; Bone Marrow/metabolism ; Cellular Senescence/genetics ; Cyclin-Dependent Kinase Inhibitor p21/genetics ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Mice ; Obesity
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Growth hormone receptor gene disruption in mature-adult mice improves male insulin sensitivity and extends female lifespan.
    Autorzy:
    Duran-Ortiz S; Edison Biotechnology Institute, Ohio University, Athens, Ohio, USA.; Molecular and Cellular Biology program, Ohio University, Athens, Ohio, USA.; Department of Biological Sciences, College of Arts and Sciences, Ohio University, Athens, Ohio, USA.
    List EO; Edison Biotechnology Institute, Ohio University, Athens, Ohio, USA.
    Ikeno Y; Barshop Institute for Longevity and Aging Studies, San Antonio, Texas, USA.
    Young J; Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA.
    Basu R; Edison Biotechnology Institute, Ohio University, Athens, Ohio, USA.
    Bell S; Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA.
    McHugh T; Department of Biological Sciences, College of Arts and Sciences, Ohio University, Athens, Ohio, USA.
    Funk K; Edison Biotechnology Institute, Ohio University, Athens, Ohio, USA.
    Mathes S; Edison Biotechnology Institute, Ohio University, Athens, Ohio, USA.
    Qian Y; Edison Biotechnology Institute, Ohio University, Athens, Ohio, USA.
    Kulkarni P; Molecular and Cellular Biology program, Ohio University, Athens, Ohio, USA.; Department of Biological Sciences, College of Arts and Sciences, Ohio University, Athens, Ohio, USA.
    Yakar S; Department of Molecular Pathobiology, David B. Kriser Dental Center, New York University College of Dentistry, New York, New York, USA.
    Berryman DE; Edison Biotechnology Institute, Ohio University, Athens, Ohio, USA.; Molecular and Cellular Biology program, Ohio University, Athens, Ohio, USA.; Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA.; Diabetes Institute, Ohio University, Athens, Ohio, USA.
    Kopchick JJ; Edison Biotechnology Institute, Ohio University, Athens, Ohio, USA.; Molecular and Cellular Biology program, Ohio University, Athens, Ohio, USA.; Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA.; Diabetes Institute, Ohio University, Athens, Ohio, USA.
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    Źródło:
    Aging cell [Aging Cell] 2021 Dec; Vol. 20 (12), pp. e13506. Date of Electronic Publication: 2021 Nov 22.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Insulin/*metabolism
    Receptors, Somatotropin/*genetics
    Aging ; Animals ; Female ; Male ; Mice ; Signal Transduction
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Chloride channel accessory 1 integrates chloride channel activity and mTORC1 in aging-related kidney injury.
    Autorzy:
    Lee HJ; Department of Medicine, Center for Renal Precision Medicine, University of Texas Health, San Antonio, TX, USA.
    Donati A; Department of Medicine, Center for Renal Precision Medicine, University of Texas Health, San Antonio, TX, USA.
    Feliers D; Department of Medicine, Center for Renal Precision Medicine, University of Texas Health, San Antonio, TX, USA.
    Sun Y; Department of Periodontics, University of Texas Health, San Antonio, TX, USA.
    Ding Y; Department of Pathology, University of Texas Health, San Antonio, TX, USA.
    Madesh M; Department of Medicine, Center for Renal Precision Medicine, University of Texas Health, San Antonio, TX, USA.
    Salmon AB; Department of Molecular Medicine, University of Texas Health, San Antonio, TX, USA.; Barshop Institute for Longevity and Aging Studies, University of Texas Health, San Antonio, TX, USA.; South Texas Veterans Health Care System, San Antonio, TX, USA.; Geriatric Research, Education & Clinical Center, South Texas Veterans Health Care System, San Antonio, TX, USA.
    Ikeno Y; Department of Pathology, University of Texas Health, San Antonio, TX, USA.; Department of Molecular Medicine, University of Texas Health, San Antonio, TX, USA.; South Texas Veterans Health Care System, San Antonio, TX, USA.
    Ross C; Texas Biomedical Research Institute, Southwest National Primate Research Center, San Antonio, TX, USA.; Department of Science and Mathematics, Texas A&M University San Antonio, San Antonio, TX, USA.
    O'Connor CL; Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
    Ju W; Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
    Bitzer M; Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
    Chen Y; Department of Population Health Sciences, University of Texas Health, San Antonio, TX, USA.; Greehey Children's Cancer Research Institute, University of Texas Health, San Antonio, TX, USA.
    Choudhury GG; Department of Medicine, Center for Renal Precision Medicine, University of Texas Health, San Antonio, TX, USA.; South Texas Veterans Health Care System, San Antonio, TX, USA.; Geriatric Research, Education & Clinical Center, South Texas Veterans Health Care System, San Antonio, TX, USA.
    Singh BB; Department of Periodontics, University of Texas Health, San Antonio, TX, USA.
    Sharma K; Department of Medicine, Center for Renal Precision Medicine, University of Texas Health, San Antonio, TX, USA.; South Texas Veterans Health Care System, San Antonio, TX, USA.
    Kasinath BS; Department of Medicine, Center for Renal Precision Medicine, University of Texas Health, San Antonio, TX, USA.; Barshop Institute for Longevity and Aging Studies, University of Texas Health, San Antonio, TX, USA.; South Texas Veterans Health Care System, San Antonio, TX, USA.; Geriatric Research, Education & Clinical Center, South Texas Veterans Health Care System, San Antonio, TX, USA.
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    Źródło:
    Aging cell [Aging Cell] 2021 Jul; Vol. 20 (7), pp. e13407. Date of Electronic Publication: 2021 Jun 12.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms:
    Acute Kidney Injury/*drug therapy
    Chloride Channels/*metabolism
    Mechanistic Target of Rapamycin Complex 1/*metabolism
    Age Factors ; Animals ; Callithrix ; Humans ; Mice ; Mice, Inbred C57BL
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Continuous overexpression of thioredoxin 1 enhances cancer development and does not extend maximum lifespan in male C57BL/6 mice.
    Autorzy:
    Flores LC; Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
    Roman MG; Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
    Cunningham GM; Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
    Cheng C; Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
    Dube S; Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
    Allen C; Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
    Van Remmen H; Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
    Hubbard GB; Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.; Department of Pathology, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
    Saunders TL; Transgenic Animal Model Core, University of Michigan, Ann Arbor, MI, USA.
    Ikeno Y; Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.; Department of Pathology, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.; Geriatric Research Education and Clinical Center (GRECC), Audie L. Murphy VA Hospital, South Texas Veterans Health Care System, San Antonio, TX, USA.
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    Źródło:
    Pathobiology of aging & age related diseases [Pathobiol Aging Age Relat Dis] 2018 Oct 23; Vol. 8 (1), pp. 1533754. Date of Electronic Publication: 2018 Oct 23 (Print Publication: 2018).
    Typ publikacji:
    Journal Article
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Significant life extension by ten percent dietary restriction.
    Autorzy:
    Richardson A; University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.; Oklahoma City VA Medical Center, Oklahoma City, Oklahoma.
    Austad SN; Department of Biology, University of Alabama at Birmingham, Birmingham, Alabama.
    Ikeno Y; Barshop Institute for Longevity and Aging Studies and Department of Pathology, University of Texas Health Science Center at San Antonio, Research Service, Audie Murphy VA Hospital (STVHCS), San Antonio, Texas.
    Unnikrishnan A; University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.
    McCarter RJ; Department of Biobehavioral Health, Pennsylvania State University, State College, Pennsylvania.
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    Źródło:
    Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2016 Jan; Vol. 1363, pp. 11-7. Date of Electronic Publication: 2015 Dec 22.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural
    MeSH Terms:
    Caloric Restriction*
    Diet*
    Life Expectancy*
    Animals ; Body Weight ; Cause of Death ; Male ; Rats
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    The Achilles' heel of senescent cells: from transcriptome to senolytic drugs.
    Autorzy:
    Zhu Y; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
    Tchkonia T; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
    Pirtskhalava T; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
    Gower AC; Section of Computational Biomedicine, Boston University School of Medicine, Boston, MA, USA.
    Ding H; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
    Giorgadze N; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
    Palmer AK; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
    Ikeno Y; Departments of Pathology, Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center, San Antonio, TX, USA.; Research Service, Geriatric Research and Education Clinical Center, Audie L. Murphy VA Hospital South Texas Veterans Health Care System, San Antonio, TX, USA.
    Hubbard GB; Departments of Pathology, Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center, San Antonio, TX, USA.; Research Service, Geriatric Research and Education Clinical Center, Audie L. Murphy VA Hospital South Texas Veterans Health Care System, San Antonio, TX, USA.
    Lenburg M; Section of Computational Biomedicine, Boston University School of Medicine, Boston, MA, USA.
    O'Hara SP; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
    LaRusso NF; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
    Miller JD; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
    Roos CM; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
    Verzosa GC; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
    LeBrasseur NK; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
    Wren JD; Department of Biochemistry and Molecular Biology, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
    Farr JN; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
    Khosla S; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
    Stout MB; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
    McGowan SJ; Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, FL, USA.
    Fuhrmann-Stroissnigg H; Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, FL, USA.
    Gurkar AU; Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, FL, USA.
    Zhao J; Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, FL, USA.
    Colangelo D; Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, FL, USA.
    Dorronsoro A; Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, FL, USA.
    Ling YY; Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, FL, USA.
    Barghouthy AS; Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, FL, USA.
    Navarro DC; Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, FL, USA.
    Sano T; Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, FL, USA.
    Robbins PD; Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, FL, USA.
    Niedernhofer LJ; Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, FL, USA.
    Kirkland JL; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
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    Źródło:
    Aging cell [Aging Cell] 2015 Aug; Vol. 14 (4), pp. 644-58. Date of Electronic Publication: 2015 Apr 22.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Transcriptome*
    Aging/*drug effects
    Cellular Senescence/*drug effects
    Dasatinib/*pharmacology
    Osteoporosis/*prevention & control
    Quercetin/*pharmacology
    Adipocytes/drug effects ; Adipocytes/metabolism ; Adipocytes/pathology ; Aging/genetics ; Aging/metabolism ; Aging/pathology ; Animals ; Carotid Arteries/drug effects ; Carotid Arteries/pathology ; Cellular Senescence/genetics ; Class I Phosphatidylinositol 3-Kinases ; Cyclin-Dependent Kinase Inhibitor p21/genetics ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Drug Combinations ; Endonucleases/genetics ; Endonucleases/metabolism ; Endothelial Cells/drug effects ; Endothelial Cells/metabolism ; Endothelial Cells/pathology ; Ephrins/genetics ; Ephrins/metabolism ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Fibroblasts/pathology ; Gene Expression Profiling ; Heart/drug effects ; Heart/physiopathology ; Intervertebral Disc/chemistry ; Intervertebral Disc/drug effects ; Intervertebral Disc/pathology ; Mesenchymal Stem Cells/drug effects ; Mesenchymal Stem Cells/metabolism ; Mesenchymal Stem Cells/pathology ; Mice ; Mice, Knockout ; Osteoporosis/genetics ; Osteoporosis/metabolism ; Osteoporosis/pathology ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Plasminogen Activator Inhibitor 2/genetics ; Plasminogen Activator Inhibitor 2/metabolism ; bcl-X Protein/genetics ; bcl-X Protein/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation.
    Autorzy:
    Laberge RM; Buck Institute for Research on Aging, Novato, California 94945, USA.
    Sun Y; 1] Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA [2] Key Lab of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
    Orjalo AV; Buck Institute for Research on Aging, Novato, California 94945, USA.
    Patil CK; Buck Institute for Research on Aging, Novato, California 94945, USA.
    Freund A; Buck Institute for Research on Aging, Novato, California 94945, USA.
    Zhou L; Buck Institute for Research on Aging, Novato, California 94945, USA.
    Curran SC; Buck Institute for Research on Aging, Novato, California 94945, USA.
    Davalos AR; Buck Institute for Research on Aging, Novato, California 94945, USA.
    Wilson-Edell KA; Buck Institute for Research on Aging, Novato, California 94945, USA.
    Liu S; Buck Institute for Research on Aging, Novato, California 94945, USA.
    Limbad C; Buck Institute for Research on Aging, Novato, California 94945, USA.
    Demaria M; Buck Institute for Research on Aging, Novato, California 94945, USA.
    Li P; Buck Institute for Research on Aging, Novato, California 94945, USA.
    Hubbard GB; 1] Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA [2] Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA.
    Ikeno Y; 1] Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA [2] Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA [3] Research Service, San Antonio, Texas 78229, USA [4] GRECC, Audie Murphy VA Hospital (STVHCS), San Antonio, Texas 78229, USA.
    Javors M; Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA.
    Desprez PY; 1] Buck Institute for Research on Aging, Novato, California 94945, USA [2] California Pacific Medical Center, Research Institute, San Francisco, California 94107, USA.
    Benz CC; Buck Institute for Research on Aging, Novato, California 94945, USA.
    Kapahi P; Buck Institute for Research on Aging, Novato, California 94945, USA.
    Nelson PS; Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
    Campisi J; Buck Institute for Research on Aging, Novato, California 94945, USA.
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    Źródło:
    Nature cell biology [Nat Cell Biol] 2015 Aug; Vol. 17 (8), pp. 1049-61. Date of Electronic Publication: 2015 Jul 06.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms:
    Interleukin-1alpha/*metabolism
    Prostatic Neoplasms/*enzymology
    TOR Serine-Threonine Kinases/*metabolism
    Animals ; Anti-Inflammatory Agents/pharmacology ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Cell Proliferation ; Cellular Senescence ; Dose-Response Relationship, Drug ; Fibroblasts/drug effects ; Fibroblasts/enzymology ; Gene Expression Regulation, Neoplastic ; Humans ; Inflammation Mediators/metabolism ; Interleukin-1alpha/genetics ; Interleukin-6/metabolism ; Male ; Mice, SCID ; Mitoxantrone/pharmacology ; NF-kappa B/metabolism ; Phenotype ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/immunology ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/pathology ; RNA Interference ; RNA, Messenger/metabolism ; Sirolimus/metabolism ; Sirolimus/pharmacology ; TOR Serine-Threonine Kinases/antagonists & inhibitors ; TOR Serine-Threonine Kinases/genetics ; Time Factors ; Transcription, Genetic ; Transfection ; Tumor Burden ; Up-Regulation ; Xenograft Model Antitumor Assays
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Reductions in serum IGF-1 during aging impair health span.
    Autorzy:
    Gong Z; Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York, 10461, USA.
    Kennedy O
    Sun H
    Wu Y
    Williams GA
    Klein L
    Cardoso L
    Matheny RW Jr
    Hubbard GB
    Ikeno Y
    Farrar RP
    Schaffler MB
    Adamo ML
    Muzumdar RH
    Yakar S
    Pokaż więcej
    Źródło:
    Aging cell [Aging Cell] 2014 Jun; Vol. 13 (3), pp. 408-18. Date of Electronic Publication: 2013 Dec 30.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Aging/*metabolism
    Insulin-Like Growth Factor I/*deficiency
    Aging/blood ; Animals ; Female ; Insulin-Like Growth Factor I/metabolism ; Male ; Mice ; Models, Animal ; Oxidative Stress/physiology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Pathology is a critical aspect of preclinical aging studies.
    Autorzy:
    Ladiges W; Department of Comparative Medicine, School of Medicine, University of Washington, Seattle, WA, USA.
    Ikeno Y
    Liggitt D
    Treuting PM
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    Źródło:
    Pathobiology of aging & age related diseases [Pathobiol Aging Age Relat Dis] 2013 Aug 20; Vol. 3. Date of Electronic Publication: 2013 Aug 20 (Print Publication: 2013).
    Typ publikacji:
    Journal Article
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Do Ames dwarf and calorie-restricted mice share common effects on age-related pathology?
    Autorzy:
    Ikeno Y; The Barshop Institute for Longevity and Aging Studies, San Antonio, TX, USA ; Department of Pathology, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
    Hubbard GB
    Lee S
    Dube SM
    Flores LC
    Roman MG
    Bartke A
    Pokaż więcej
    Źródło:
    Pathobiology of aging & age related diseases [Pathobiol Aging Age Relat Dis] 2013 Jun 20; Vol. 3. Date of Electronic Publication: 2013 Jun 20 (Print Publication: 2013).
    Typ publikacji:
    Journal Article
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Decreased insulin sensitivity and increased oxidative damage in wasting adipose tissue depots of wild-type mice.
    Autorzy:
    Sackmann-Sala L; Edison Biotechnology Institute, Ohio University, 1 Water Tower Dr., The Ridges, Athens, OH 45701, USA.
    Berryman DE
    Lubbers ER
    Vesel CB
    Troike KM
    List EO
    Munn RD
    Ikeno Y
    Kopchick JJ
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    Źródło:
    Age (Dordrecht, Netherlands) [Age (Dordr)] 2012 Oct; Vol. 34 (5), pp. 1225-37. Date of Electronic Publication: 2011 Sep 29.
    Typ publikacji:
    Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms:
    Oxidative Stress*
    Adipose Tissue/*metabolism
    Adipose Tissue, White/*metabolism
    Aging/*physiology
    Insulin/*metabolism
    Insulin Resistance/*physiology
    Obesity/*metabolism
    Adipocytes/metabolism ; Adipose Tissue, White/pathology ; Animals ; Disease Models, Animal ; Male ; Mice ; Mice, Inbred C57BL ; Obesity/pathology ; Proteomics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Reduction of glucose intolerance with high fat feeding is associated with anti-inflammatory effects of thioredoxin 1 overexpression in mice.
    Autorzy:
    Salmon AB; The Sam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, TX, USA.
    Flores LC
    Li Y
    Van Remmen H
    Richardson A
    Ikeno Y
    Pokaż więcej
    Źródło:
    Pathobiology of aging & age related diseases [Pathobiol Aging Age Relat Dis] 2012; Vol. 2. Date of Electronic Publication: 2012 May 17.
    Typ publikacji:
    Journal Article
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Differential effects of enalapril and losartan on body composition and indices of muscle quality in aged male Fischer 344 × Brown Norway rats.
    Autorzy:
    Carter CS; Department of Aging and Geriatric Research, Institute on Aging, University of Florida, Gainesville, FL 32610, USA. />Giovannini S
    Seo DO
    DuPree J
    Morgan D
    Chung HY
    Lees H
    Daniels M
    Hubbard GB
    Lee S
    Ikeno Y
    Foster TC
    Buford TW
    Marzetti E
    Pokaż więcej
    Źródło:
    Age (Dordrecht, Netherlands) [Age (Dordr)] 2011 Jun; Vol. 33 (2), pp. 167-83. Date of Electronic Publication: 2010 Dec 14.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Muscle Strength*
    Adiposity/*drug effects
    Aging/*pathology
    Angiotensin Receptor Antagonists/*pharmacology
    Angiotensin-Converting Enzyme Inhibitors/*pharmacology
    Body Composition/*drug effects
    Enalapril/*pharmacology
    Losartan/*pharmacology
    Muscle, Skeletal/*pathology
    Muscle, Skeletal/*physiology
    Animals ; Blood Glucose/analysis ; Body Temperature ; Body Weight ; Eating ; Insulin/blood ; Magnetic Resonance Spectroscopy ; Male ; Mitochondria, Muscle/metabolism ; Motor Activity ; Rats ; Rats, Inbred F344
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Does reduced IGF-1R signaling in Igf1r+/- mice alter aging?
    Autorzy:
    Bokov AF; Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America.
    Garg N
    Ikeno Y
    Thakur S
    Musi N
    DeFronzo RA
    Zhang N
    Erickson RC
    Gelfond J
    Hubbard GB
    Adamo ML
    Richardson A
    Pokaż więcej
    Źródło:
    PloS one [PLoS One] 2011; Vol. 6 (11), pp. e26891. Date of Electronic Publication: 2011 Nov 23.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms:
    Signal Transduction*/drug effects
    Aging/*physiology
    Receptor, IGF Type 1/*metabolism
    Aging/drug effects ; Animals ; Female ; Gene Expression Regulation/drug effects ; Glucose Tolerance Test ; Glycogen Synthase Kinase 3/metabolism ; Glycogen Synthase Kinase 3 beta ; Humans ; Insulin/pharmacology ; Insulin-Like Growth Factor Binding Protein 5/genetics ; Insulin-Like Growth Factor Binding Protein 5/metabolism ; Insulin-Like Growth Factor I/pharmacology ; Longevity ; Male ; Mice ; Mice, Inbred C57BL ; Oxidative Stress/drug effects ; Phosphorylation/drug effects ; Proto-Oncogene Proteins c-akt/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    The anti-tumor effects of calorie restriction are correlated with reduced oxidative stress in ENU-induced gliomas.
    Autorzy:
    Mahlke MA; Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, TX, USA.
    Cortez LA
    Ortiz MA
    Rodriguez M
    Uchida K
    Shigenaga MK
    Lee S
    Zhang Y
    Tominaga K
    Hubbard GB
    Ikeno Y
    Pokaż więcej
    Źródło:
    Pathobiology of aging & age related diseases [Pathobiol Aging Age Relat Dis] 2011; Vol. 1. Date of Electronic Publication: 2011 Jun 01.
    Typ publikacji:
    Journal Article
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Long-term IGF-I exposure decreases autophagy and cell viability.
    Autorzy:
    Bitto A; Department of Pathology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.
    Lerner C
    Torres C
    Roell M
    Malaguti M
    Perez V
    Lorenzini A
    Hrelia S
    Ikeno Y
    Matzko ME
    McCarter R
    Sell C
    Pokaż więcej
    Źródło:
    PloS one [PLoS One] 2010 Sep 07; Vol. 5 (9), pp. e12592. Date of Electronic Publication: 2010 Sep 07.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural
    MeSH Terms:
    Autophagy*
    Fibroblasts/*cytology
    Fibroblasts/*metabolism
    Insulin-Like Growth Factor I/*metabolism
    Animals ; Apoptosis ; Cell Survival ; Cells, Cultured ; Mice ; Mitochondria/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Lifespan extension in genetically modified mice.
    Autorzy:
    Ladiges W; Department of Comparative Medicine, University of Washington, Seattle, 98195, USA. />Van Remmen H
    Strong R
    Ikeno Y
    Treuting P
    Rabinovitch P
    Richardson A
    Pokaż więcej
    Źródło:
    Aging cell [Aging Cell] 2009 Aug; Vol. 8 (4), pp. 346-52. Date of Electronic Publication: 2009 May 22.
    Typ publikacji:
    Journal Article; Review
    MeSH Terms:
    Longevity/*genetics
    Animals ; Animals, Genetically Modified ; Humans ; Mice ; Mice, Transgenic ; Models, Animal
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
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