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    Podgląd okładki
    Tytuł :
    Non-neutralizing Antibodies from a Marburg Infection Survivor Mediate Protection by Fc-Effector Functions and by Enhancing Efficacy of Other Antibodies.
    Autorzy :
    Ilinykh PA; Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA; Galveston National Laboratory, Galveston, TX, USA.
    Huang K; Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA; Galveston National Laboratory, Galveston, TX, USA.
    Santos RI; Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA; Galveston National Laboratory, Galveston, TX, USA.
    Gilchuk P; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA.
    Gunn BM; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.
    Karim MM; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.
    Liang J; Integral Molecular, Philadelphia, PA 19104, USA.
    Fouch ME; Integral Molecular, Philadelphia, PA 19104, USA.
    Davidson E; Integral Molecular, Philadelphia, PA 19104, USA.
    Parekh DV; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
    Kimble JB; Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA; Galveston National Laboratory, Galveston, TX, USA.
    Pietzsch CA; Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA; Galveston National Laboratory, Galveston, TX, USA.
    Meyer M; Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA; Galveston National Laboratory, Galveston, TX, USA.
    Kuzmina NA; Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA; Galveston National Laboratory, Galveston, TX, USA.
    Zeitlin L; Mapp Biopharmaceutical, San Diego, CA, USA.
    Saphire EO; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA; Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA.
    Alter G; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.
    Crowe JE Jr; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Pediatrics (Infectious Diseases), Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address: .
    Bukreyev A; Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX; Galveston National Laboratory, Galveston, TX, USA. Electronic address: .
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    Źródło :
    Cell host & microbe [Cell Host Microbe] 2020 Jun 10; Vol. 27 (6), pp. 976-991.e11. Date of Electronic Publication: 2020 Apr 21.
    Typ publikacji :
    Journal Article
    MeSH Terms :
    Antibodies, Neutralizing/*immunology
    Antibodies, Viral/*immunology
    Marburg Virus Disease/*immunology
    Marburgvirus/*immunology
    Animals ; Antibodies, Monoclonal/immunology ; B-Lymphocytes ; Chlorocebus aethiops ; Disease Models, Animal ; Ebolavirus/immunology ; Epitopes/immunology ; Female ; Glycoproteins/immunology ; Guinea Pigs ; HEK293 Cells ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Survivors ; THP-1 Cells ; Vero Cells ; Viral Envelope Proteins/immunology
    Czasopismo naukowe
    Szczegóły
    Podgląd okładki
    Tytuł :
    Analysis of a Therapeutic Antibody Cocktail Reveals Determinants for Cooperative and Broad Ebolavirus Neutralization.
    Autorzy :
    Gilchuk P; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
    Murin CD; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Milligan JC; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Cross RW; Galveston National Laboratory, Galveston, TX 77550, USA; Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.
    Mire CE; Galveston National Laboratory, Galveston, TX 77550, USA; Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.
    Ilinykh PA; Galveston National Laboratory, Galveston, TX 77550, USA; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.
    Huang K; Galveston National Laboratory, Galveston, TX 77550, USA; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.
    Kuzmina N; Galveston National Laboratory, Galveston, TX 77550, USA; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.
    Altman PX; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Hui S; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Gunn BM; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
    Bryan AL; Integral Molecular, Inc., Philadelphia, PA 19104, USA.
    Davidson E; Integral Molecular, Inc., Philadelphia, PA 19104, USA.
    Doranz BJ; Integral Molecular, Inc., Philadelphia, PA 19104, USA.
    Turner HL; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Alkutkar T; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Flinko R; Division of Vaccine Research, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
    Orlandi C; Division of Vaccine Research, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
    Carnahan R; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
    Nargi R; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
    Bombardi RG; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
    Vodzak ME; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
    Li S; Department of Medicine, University of California, San Diego, San Diego, CA 92093, USA.
    Okoli A; First Consultants Medical Center, Lagos, Nigeria.
    Ibeawuchi M; First Consultants Medical Center, Lagos, Nigeria.
    Ohiaeri B; First Consultants Medical Center, Lagos, Nigeria.
    Lewis GK; Division of Vaccine Research, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
    Alter G; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
    Bukreyev A; Galveston National Laboratory, Galveston, TX 77550, USA; Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.
    Saphire EO; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Geisbert TW; Galveston National Laboratory, Galveston, TX 77550, USA; Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.
    Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Crowe JE Jr; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Electronic address: .
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    Źródło :
    Immunity [Immunity] 2020 Feb 18; Vol. 52 (2), pp. 388-403.e12. Date of Electronic Publication: 2020 Feb 04.
    Typ publikacji :
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms :
    Antibodies, Monoclonal/*immunology
    Antibodies, Neutralizing/*immunology
    Antibodies, Viral/*immunology
    Ebolavirus/*immunology
    Glycoproteins/*immunology
    Hemorrhagic Fever, Ebola/*immunology
    Animals ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Neutralizing/therapeutic use ; Antibodies, Viral/therapeutic use ; Cell Line ; Disease Models, Animal ; Drug Therapy, Combination ; Epitopes ; Female ; Glycoproteins/chemistry ; Hemorrhagic Fever, Ebola/prevention & control ; Humans ; Immunoglobulin Fab Fragments/immunology ; Macaca mulatta ; Male ; Mice ; Mice, Inbred BALB C ; Molecular Mimicry ; Protein Conformation
    Czasopismo naukowe
    Szczegóły
    Podgląd okładki
    Tytuł :
    Cross-reactive neutralizing human survivor monoclonal antibody BDBV223 targets the ebolavirus stalk.
    Autorzy :
    King LB; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, 92037, USA.
    West BR; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, 92037, USA.
    Moyer CL; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, 92037, USA.
    Gilchuk P; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
    Flyak A; Departments of Pediatrics, Pathology, and Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
    Ilinykh PA; Department of Pathology, University of Texas Medical Branch, Galveston, TX, 77555, USA.; Galveston National Laboratory, Galveston, TX, 77555, USA.
    Bombardi R; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
    Hui S; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, 92037, USA.
    Huang K; Department of Pathology, University of Texas Medical Branch, Galveston, TX, 77555, USA.; Galveston National Laboratory, Galveston, TX, 77555, USA.
    Bukreyev A; Department of Pathology, University of Texas Medical Branch, Galveston, TX, 77555, USA.; Galveston National Laboratory, Galveston, TX, 77555, USA.; Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX, 77555, USA.
    Crowe JE Jr; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.; Departments of Pediatrics, Pathology, and Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
    Saphire EO; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, 92037, USA. .; Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA. .; La Jolla Institute for Immunology La Jolla, CA, 92037, USA. .
    Pokaż więcej
    Źródło :
    Nature communications [Nat Commun] 2019 Apr 17; Vol. 10 (1), pp. 1788. Date of Electronic Publication: 2019 Apr 17.
    Typ publikacji :
    Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms :
    Antibodies, Monoclonal/*immunology
    Antibodies, Neutralizing/*immunology
    Antibodies, Viral/*immunology
    Ebolavirus/*drug effects
    Hemorrhagic Fever, Ebola/*immunology
    Antibodies, Monoclonal/chemistry ; Antibodies, Monoclonal/isolation & purification ; Antibodies, Monoclonal/metabolism ; Antibodies, Neutralizing/chemistry ; Antibodies, Neutralizing/isolation & purification ; Antibodies, Neutralizing/metabolism ; Antibodies, Viral/chemistry ; Antibodies, Viral/isolation & purification ; Antibodies, Viral/metabolism ; Cross Reactions/immunology ; Crystallography, X-Ray ; Ebolavirus/immunology ; Epitopes/chemistry ; Epitopes/immunology ; Hemorrhagic Fever, Ebola/blood ; Hemorrhagic Fever, Ebola/virology ; Humans ; Hybridomas ; Mutagenesis ; Survivors ; Viral Envelope Proteins/chemistry ; Viral Envelope Proteins/immunology ; Viral Envelope Proteins/metabolism
    Czasopismo naukowe
    Szczegóły
    Podgląd okładki
    Tytuł :
    Structural basis of broad ebolavirus neutralization by a human survivor antibody.
    Autorzy :
    West BR; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
    Wec AZ; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.; Adimab LLC, Lebanon, NH, USA.
    Moyer CL; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; Mapp Biopharmaceutical, San Diego, CA, USA.
    Fusco ML; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
    Ilinykh PA; Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA.; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA.
    Huang K; Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA.; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA.
    Wirchnianski AS; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.
    James RM; Division of Virology, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA.
    Herbert AS; Division of Virology, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA.
    Hui S; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
    Goodwin E; Adimab LLC, Lebanon, NH, USA.
    Howell KA; Integrated Biotherapeutics, Rockville, MD, USA.
    Kailasan S; Integrated Biotherapeutics, Rockville, MD, USA.
    Aman MJ; Integrated Biotherapeutics, Rockville, MD, USA.
    Walker LM; Adimab LLC, Lebanon, NH, USA.
    Dye JM; Division of Virology, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA.
    Bukreyev A; Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA.; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA.; Department of Immunology and Microbiology, University of Texas Medical Branch, Galveston, TX, USA.
    Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA. .
    Saphire EO; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA. .; Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA. .
    Pokaż więcej
    Źródło :
    Nature structural & molecular biology [Nat Struct Mol Biol] 2019 Mar; Vol. 26 (3), pp. 204-212. Date of Electronic Publication: 2019 Mar 04.
    Typ publikacji :
    Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms :
    Antibodies, Neutralizing/*immunology
    Antibodies, Viral/*immunology
    Ebolavirus/*immunology
    Viral Fusion Proteins/*immunology
    Antibodies, Monoclonal/immunology ; Antibody Affinity/immunology ; Crystallography, X-Ray ; Humans ; Protein Structure, Tertiary ; Survivors
    Czasopismo naukowe
    Szczegóły
    Podgląd okładki
    Tytuł :
    Ebolavirus Chimerization for the Development of a Mouse Model for Screening of Bundibugyo-Specific Antibodies.
    Autorzy :
    Ilinykh PA; Department of Pathology, University of Texas Medical Branch, Galveston.; Galveston National Laboratory, University of Texas Medical Branch, Galveston.
    Graber J; Galveston National Laboratory, University of Texas Medical Branch, Galveston.
    Kuzmina NA; Department of Pathology, University of Texas Medical Branch, Galveston.; Galveston National Laboratory, University of Texas Medical Branch, Galveston.
    Huang K; Department of Pathology, University of Texas Medical Branch, Galveston.; Galveston National Laboratory, University of Texas Medical Branch, Galveston.
    Ksiazek TG; Department of Pathology, University of Texas Medical Branch, Galveston.; Galveston National Laboratory, University of Texas Medical Branch, Galveston.
    Crowe JE Jr; Vanderbilt Vaccine Center, Vanderbilt University Medical Center.; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center.; Chemical and Physical Biology Program, Vanderbilt University.; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee.
    Bukreyev A; Department of Pathology, University of Texas Medical Branch, Galveston.; Galveston National Laboratory, University of Texas Medical Branch, Galveston.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston.
    Pokaż więcej
    Źródło :
    The Journal of infectious diseases [J Infect Dis] 2018 Nov 22; Vol. 218 (suppl_5), pp. S418-S422.
    Typ publikacji :
    Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms :
    Antibodies, Monoclonal/*immunology
    Antibodies, Viral/*immunology
    Ebolavirus/*immunology
    Animals ; Antibodies, Neutralizing/immunology ; Chlorocebus aethiops ; Disease Models, Animal ; Hemorrhagic Fever, Ebola/immunology ; Mice ; Mice, Knockout ; Vero Cells ; Viral Envelope Proteins/immunology
    Czasopismo naukowe
    Szczegóły
    Podgląd okładki
    Tytuł :
    Asymmetric antiviral effects of ebolavirus antibodies targeting glycoprotein stem and glycan cap.
    Autorzy :
    Ilinykh PA; Department of Pathology, University of Texas Medical Branch, Galveston, TX, United States of America.; Galveston National Laboratory, Galveston, TX, United States of America.
    Santos RI; Department of Pathology, University of Texas Medical Branch, Galveston, TX, United States of America.
    Gunn BM; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, United States of America.
    Kuzmina NA; Department of Pathology, University of Texas Medical Branch, Galveston, TX, United States of America.; Galveston National Laboratory, Galveston, TX, United States of America.
    Shen X; Department of Pathology, University of Texas Medical Branch, Galveston, TX, United States of America.; Galveston National Laboratory, Galveston, TX, United States of America.
    Huang K; Department of Pathology, University of Texas Medical Branch, Galveston, TX, United States of America.; Galveston National Laboratory, Galveston, TX, United States of America.
    Gilchuk P; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, United States of America.
    Flyak AI; Departments of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States of America.
    Younan P; Department of Pathology, University of Texas Medical Branch, Galveston, TX, United States of America.; Galveston National Laboratory, Galveston, TX, United States of America.
    Alter G; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, United States of America.
    Crowe JE Jr; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, United States of America.; Departments of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States of America.; Department of Pediatrics (Infectious Diseases), Vanderbilt University Medical Center, Nashville, TN, United States of America.
    Bukreyev A; Department of Pathology, University of Texas Medical Branch, Galveston, TX, United States of America.; Galveston National Laboratory, Galveston, TX, United States of America.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, United States of America.
    Pokaż więcej
    Źródło :
    PLoS pathogens [PLoS Pathog] 2018 Aug 23; Vol. 14 (8), pp. e1007204. Date of Electronic Publication: 2018 Aug 23 (Print Publication: 2018).
    Typ publikacji :
    Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms :
    Antibodies, Viral/*immunology
    Ebolavirus/*immunology
    Hemorrhagic Fever, Ebola/*immunology
    Viral Envelope Proteins/*antagonists & inhibitors
    Antibodies, Monoclonal/immunology ; Humans
    Czasopismo naukowe
    Szczegóły Pełny tekst Pełny tekst
    Podgląd okładki
    Tytuł :
    Multifunctional Pan-ebolavirus Antibody Recognizes a Site of Broad Vulnerability on the Ebolavirus Glycoprotein.
    Autorzy :
    Gilchuk P; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
    Kuzmina N; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA; Galveston National Laboratory, Galveston, TX 77550, USA.
    Ilinykh PA; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA; Galveston National Laboratory, Galveston, TX 77550, USA.
    Huang K; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA; Galveston National Laboratory, Galveston, TX 77550, USA.
    Gunn BM; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
    Bryan A; Integral Molecular, Inc., Philadelphia, PA 19104, USA.
    Davidson E; Integral Molecular, Inc., Philadelphia, PA 19104, USA.
    Doranz BJ; Integral Molecular, Inc., Philadelphia, PA 19104, USA.
    Turner HL; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Fusco ML; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Bramble MS; Department of Epidemiology, Jonathan and Karin Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Genetic Medicine Research, Children's Research Institute, Children's National Medical Center, Washington, DC 20010, USA.
    Hoff NA; Department of Epidemiology, Jonathan and Karin Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA 90095, USA.
    Binshtein E; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232, USA.
    Kose N; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
    Flyak AI; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
    Flinko R; Division of Vaccine Research, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
    Orlandi C; Division of Vaccine Research, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
    Carnahan R; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
    Parrish EH; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
    Sevy AM; Chemical and Physical Biology Program, Vanderbilt University, Nashville, TN 37232, USA.
    Bombardi RG; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
    Singh PK; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232, USA.
    Mukadi P; Institut Nationale de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo.
    Muyembe-Tamfum JJ; Institut Nationale de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo.
    Ohi MD; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232, USA.
    Saphire EO; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Lewis GK; Division of Vaccine Research, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
    Alter G; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
    Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Rimoin AW; Department of Epidemiology, Jonathan and Karin Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA 90095, USA.
    Bukreyev A; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA; Galveston National Laboratory, Galveston, TX 77550, USA; Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA. Electronic address: .
    Crowe JE Jr; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Chemical and Physical Biology Program, Vanderbilt University, Nashville, TN 37232, USA; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Electronic address: .
    Pokaż więcej
    Źródło :
    Immunity [Immunity] 2018 Aug 21; Vol. 49 (2), pp. 363-374.e10. Date of Electronic Publication: 2018 Jul 17.
    Typ publikacji :
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms :
    Antibodies, Monoclonal/*immunology
    Antibodies, Monoclonal/*pharmacology
    Antibodies, Neutralizing/*immunology
    Antibodies, Neutralizing/*pharmacology
    Antibodies, Viral/*immunology
    Antibodies, Viral/*pharmacology
    Ebolavirus/*immunology
    Glycoproteins/*immunology
    Hemorrhagic Fever, Ebola/*immunology
    3T3 Cells ; Adult ; Animals ; CHO Cells ; Cell Line ; Chlorocebus aethiops ; Cricetulus ; Disease Models, Animal ; Drosophila ; Female ; Ferrets ; Guinea Pigs ; Hemorrhagic Fever, Ebola/prevention & control ; Hemorrhagic Fever, Ebola/virology ; Humans ; Immunoglobulin G/immunology ; Jurkat Cells ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Knockout ; THP-1 Cells ; Vero Cells
    Czasopismo naukowe
    Szczegóły
    Podgląd okładki
    Tytuł :
    Antibody-Dependent Enhancement of Ebola Virus Infection by Human Antibodies Isolated from Survivors.
    Autorzy :
    Kuzmina NA; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA; Galveston National Laboratory, Galveston, TX 77550, USA.
    Younan P; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA; Galveston National Laboratory, Galveston, TX 77550, USA.
    Gilchuk P; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
    Santos RI; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA; Galveston National Laboratory, Galveston, TX 77550, USA.
    Flyak AI; Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN 37232, USA.
    Ilinykh PA; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA; Galveston National Laboratory, Galveston, TX 77550, USA.
    Huang K; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA; Galveston National Laboratory, Galveston, TX 77550, USA.
    Lubaki NM; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA; Galveston National Laboratory, Galveston, TX 77550, USA.
    Ramanathan P; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA; Galveston National Laboratory, Galveston, TX 77550, USA.
    Crowe JE Jr; Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Electronic address: .
    Bukreyev A; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA; Galveston National Laboratory, Galveston, TX 77550, USA; Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA. Electronic address: .
    Pokaż więcej
    Źródło :
    Cell reports [Cell Rep] 2018 Aug 14; Vol. 24 (7), pp. 1802-1815.e5.
    Typ publikacji :
    Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms :
    Antibody-Dependent Enhancement*
    Antibodies, Monoclonal/*pharmacology
    Antibodies, Neutralizing/*pharmacology
    Antibodies, Viral/*pharmacology
    Hemorrhagic Fever, Ebola/*virology
    Marburg Virus Disease/*virology
    Animals ; Antibodies, Monoclonal/isolation & purification ; Antibodies, Neutralizing/isolation & purification ; Antibodies, Viral/isolation & purification ; Ebolavirus/drug effects ; Ebolavirus/genetics ; Ebolavirus/immunology ; Ebolavirus/pathogenicity ; Epitopes/genetics ; Epitopes/immunology ; Gene Expression ; Genes, Reporter ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; Hemorrhagic Fever, Ebola/immunology ; Hemorrhagic Fever, Ebola/mortality ; Hemorrhagic Fever, Ebola/therapy ; Humans ; Immune Sera/chemistry ; Immunoglobulin Fc Fragments/chemistry ; Immunoglobulin Fc Fragments/genetics ; Marburg Virus Disease/immunology ; Marburg Virus Disease/mortality ; Marburg Virus Disease/therapy ; Marburgvirus/drug effects ; Marburgvirus/genetics ; Marburgvirus/pathogenicity ; Mice ; Mice, Inbred BALB C ; Monocytes/drug effects ; Monocytes/immunology ; Monocytes/virology ; Primary Cell Culture ; Receptors, IgG/genetics ; Receptors, IgG/immunology ; Survival Analysis ; Survivors ; THP-1 Cells ; Viral Envelope Proteins/genetics ; Viral Envelope Proteins/immunology
    Czasopismo naukowe
    Szczegóły
    Podgląd okładki
    Tytuł :
    The Marburgvirus-Neutralizing Human Monoclonal Antibody MR191 Targets a Conserved Site to Block Virus Receptor Binding.
    Autorzy :
    King LB; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Fusco ML; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Flyak AI; Departments of Pediatrics, Pathology, Microbiology, and Immunology, and the Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
    Ilinykh PA; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA; Galveston National Laboratory, Galveston, TX 77550, USA.
    Huang K; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA; Galveston National Laboratory, Galveston, TX 77550, USA.
    Gunn B; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA.
    Kirchdoerfer RN; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Hastie KM; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Sangha AK; Department of Chemistry and Center for Structural Biology, Vanderbilt University, Nashville, TN 37232, USA.
    Meiler J; Department of Chemistry and Center for Structural Biology, Vanderbilt University, Nashville, TN 37232, USA.
    Alter G; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA.
    Bukreyev A; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA; Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA; Galveston National Laboratory, Galveston, TX 77550, USA.
    Crowe JE Jr; Departments of Pediatrics, Pathology, Microbiology, and Immunology, and the Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
    Saphire EO; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA; Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: .
    Pokaż więcej
    Źródło :
    Cell host & microbe [Cell Host Microbe] 2018 Jan 10; Vol. 23 (1), pp. 101-109.e4.
    Typ publikacji :
    Journal Article
    MeSH Terms :
    Antibodies, Monoclonal/*immunology
    Antibodies, Neutralizing/*immunology
    Antibodies, Viral/*immunology
    Marburgvirus/*immunology
    Receptors, Virus/*immunology
    Receptors, Virus/*ultrastructure
    Viral Fusion Proteins/*immunology
    Viral Fusion Proteins/*ultrastructure
    Agrobacterium tumefaciens ; Animals ; Antibodies, Monoclonal/ultrastructure ; Binding Sites/immunology ; Carrier Proteins/immunology ; Cell Line ; Chlorocebus aethiops ; Crystallography, X-Ray ; Drosophila melanogaster ; Humans ; Intracellular Signaling Peptides and Proteins ; Marburgvirus/metabolism ; Membrane Glycoproteins/immunology ; Tobacco ; Vero Cells ; Viral Envelope Proteins/genetics ; Viral Envelope Proteins/immunology ; Virus Attachment
    Czasopismo naukowe
    Szczegóły
    Podgląd okładki
    Tytuł :
    Chimeric Filoviruses for Identification and Characterization of Monoclonal Antibodies.
    Autorzy :
    Ilinykh PA; Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.; Galveston National Laboratory, Galveston, Texas, USA.
    Shen X; Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.; Galveston National Laboratory, Galveston, Texas, USA.
    Flyak AI; Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, Tennessee, USA.
    Kuzmina N; Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.; Galveston National Laboratory, Galveston, Texas, USA.
    Ksiazek TG; Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.; Galveston National Laboratory, Galveston, Texas, USA.
    Crowe JE Jr; Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, Tennessee, USA.; Vanderbilt Vaccine Center, Vanderbilt University, Nashville, Tennessee, USA.; Department of Pediatrics, Vanderbilt University, Nashville, Tennessee, USA.
    Bukreyev A; Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA .; Galveston National Laboratory, Galveston, Texas, USA.
    Pokaż więcej
    Źródło :
    Journal of virology [J Virol] 2016 Mar 28; Vol. 90 (8), pp. 3890-3901. Date of Electronic Publication: 2016 Mar 28 (Print Publication: 2016).
    Typ publikacji :
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms :
    Antibodies, Monoclonal/*immunology
    Antibodies, Viral/*immunology
    Filoviridae/*immunology
    Animals ; Antibodies, Neutralizing/immunology ; Chlorocebus aethiops ; Filoviridae/genetics ; Humans ; Recombinant Proteins/genetics ; Recombinant Proteins/immunology ; Reverse Genetics ; Vero Cells ; Viral Envelope Proteins/genetics ; Viral Envelope Proteins/immunology
    Czasopismo naukowe
    Szczegóły
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