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Tytuł :
Genetic and biological characterization of avian influenza H5N1 viruses isolated from wild birds and poultry in Western Siberia
Autorzy :
Sharshov, Kirill
Romanovskaya, Alesia
Uzhachenko, Roman
Durymanov, Alexander
Zaykovskaya, Anna
Kurskaya, Olga
Ilinykh, Philipp
Silko, Nikita
Kulak, Mikhail
Alekseev, Alexander
Zolotykh, Sergei
Shestopalov, Alexander
Drozdov, Iliya
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Źródło :
Archives of Virology: Official Journal of the Virology Division of the International Union of Microbiological Societies. July 2010 155(7):1145-1150
Czasopismo naukowe
Tytuł :
Mechanism of human antibody-mediated neutralization of Marburg virus.
Autorzy :
Flyak AI; Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN 37232, USA.
Ilinykh PA; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA; Galveston National Laboratory, Galveston, TX 77550, USA.
Murin CD; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Garron T; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA; Galveston National Laboratory, Galveston, TX 77550, USA.
Shen X; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA; Galveston National Laboratory, Galveston, TX 77550, USA.
Fusco ML; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Hashiguchi T; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Bornholdt ZA; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Slaughter JC; Vanderbilt Vaccine Center, Vanderbilt University, Nashville, TN 37232, USA; Department of Biostatistics, Vanderbilt University, Nashville, TN 37232, USA.
Sapparapu G; Vanderbilt Vaccine Center, Vanderbilt University, Nashville, TN 37232, USA.
Klages C; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA; Galveston National Laboratory, Galveston, TX 77550, USA.
Ksiazek TG; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA; Galveston National Laboratory, Galveston, TX 77550, USA.
Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Saphire EO; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Bukreyev A; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA; Galveston National Laboratory, Galveston, TX 77550, USA.
Crowe JE Jr; Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN 37232, USA; Department of Pediatrics, Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt Vaccine Center, Vanderbilt University, Nashville, TN 37232, USA. Electronic address: .
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Źródło :
Cell [Cell] 2015 Feb 26; Vol. 160 (5), pp. 893-903.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Antibodies, Neutralizing/*chemistry
Antibodies, Neutralizing/*immunology
Antigen-Antibody Complex/*ultrastructure
Marburg Virus Disease/*immunology
Marburgvirus/*chemistry
Viral Envelope Proteins/*chemistry
Adult ; Animals ; Antibodies, Monoclonal/chemistry ; Antibodies, Monoclonal/metabolism ; Antibodies, Neutralizing/isolation & purification ; Antibodies, Neutralizing/metabolism ; Antibodies, Viral/chemistry ; Antibodies, Viral/immunology ; Antibodies, Viral/metabolism ; B-Lymphocytes/immunology ; Female ; Humans ; Immunoglobulin Fab Fragments/chemistry ; Immunoglobulin Fab Fragments/metabolism ; Marburgvirus/genetics ; Marburgvirus/immunology ; Models, Molecular ; Mutation ; Protein Structure, Tertiary ; Viral Envelope Proteins/metabolism
Czasopismo naukowe
Tytuł :
Different Temporal Effects of Ebola Virus VP35 and VP24 Proteins on Global Gene Expression in Human Dendritic Cells.
Autorzy :
Ilinykh PA; Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA Galveston National Laboratory, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
Lubaki NM; Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA Galveston National Laboratory, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
Widen SG; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
Renn LA; Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.
Theisen TC; Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.
Rabin RL; Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.
Wood TG; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
Bukreyev A; Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA Department of Microbiology & Immunology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA Galveston National Laboratory, University of Texas Medical Branch at Galveston, Galveston, Texas, USA .
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Źródło :
Journal of virology [J Virol] 2015 Aug; Vol. 89 (15), pp. 7567-83. Date of Electronic Publication: 2015 May 13.
Typ publikacji :
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression*
Dendritic Cells/*metabolism
Ebolavirus/*metabolism
Hemorrhagic Fever, Ebola/*genetics
Interferons/*genetics
Nucleoproteins/*metabolism
Viral Core Proteins/*metabolism
Viral Proteins/*metabolism
Cells, Cultured ; Dendritic Cells/virology ; Ebolavirus/chemistry ; Ebolavirus/genetics ; Hemorrhagic Fever, Ebola/metabolism ; Hemorrhagic Fever, Ebola/virology ; Humans ; Interferons/metabolism ; Nucleocapsid Proteins ; Nucleoproteins/chemistry ; Nucleoproteins/genetics ; Protein Structure, Tertiary ; Signal Transduction ; Viral Core Proteins/chemistry ; Viral Core Proteins/genetics ; Viral Proteins/chemistry ; Viral Proteins/genetics
Czasopismo naukowe
Tytuł :
Cross-Reactive and Potent Neutralizing Antibody Responses in Human Survivors of Natural Ebolavirus Infection.
Autorzy :
Flyak AI; Department of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, TN 37232, USA.
Shen X; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Murin CD; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Turner HL; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
David JA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Fusco ML; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Lampley R; Vanderbilt Vaccine Center, Vanderbilt University, Nashville, TN 37232, USA.
Kose N; Vanderbilt Vaccine Center, Vanderbilt University, Nashville, TN 37232, USA.
Ilinykh PA; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Kuzmina N; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Branchizio A; Vanderbilt Vaccine Center, Vanderbilt University, Nashville, TN 37232, USA.
King H; Vanderbilt Vaccine Center, Vanderbilt University, Nashville, TN 37232, USA.
Brown L; Vanderbilt Vaccine Center, Vanderbilt University, Nashville, TN 37232, USA.
Bryan C; Integral Molecular Inc., Philadelphia, PA 19104, USA.
Davidson E; Integral Molecular Inc., Philadelphia, PA 19104, USA.
Doranz BJ; Integral Molecular Inc., Philadelphia, PA 19104, USA.
Slaughter JC; Vanderbilt Vaccine Center, Vanderbilt University, Nashville, TN 37232, USA; Department of Biostatistics, Vanderbilt University, Nashville, TN 37232, USA.
Sapparapu G; Vanderbilt Vaccine Center, Vanderbilt University, Nashville, TN 37232, USA.
Klages C; Galveston National Laboratory, Galveston, TX 77550, USA.
Ksiazek TG; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA; Galveston National Laboratory, Galveston, TX 77550, USA.
Saphire EO; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Bukreyev A; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA; Galveston National Laboratory, Galveston, TX 77550, USA. Electronic address: .
Crowe JE Jr; Department of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, TN 37232, USA; Department of Pediatrics, Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt Vaccine Center, Vanderbilt University, Nashville, TN 37232, USA. Electronic address: .
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Źródło :
Cell [Cell] 2016 Jan 28; Vol. 164 (3), pp. 392-405. Date of Electronic Publication: 2016 Jan 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Survivors*
Antibodies, Monoclonal/*immunology
Antibodies, Neutralizing/*immunology
Ebolavirus/*immunology
Hemorrhagic Fever, Ebola/*immunology
Animals ; Cross Reactions ; Disease Models, Animal ; Epitope Mapping ; Guinea Pigs ; Humans ; Mice ; Mice, Inbred BALB C ; Microscopy, Electron ; Models, Molecular ; Mutagenesis ; Uganda
Czasopismo naukowe
Tytuł :
Chimeric Filoviruses for Identification and Characterization of Monoclonal Antibodies.
Autorzy :
Ilinykh PA; Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.; Galveston National Laboratory, Galveston, Texas, USA.
Shen X; Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.; Galveston National Laboratory, Galveston, Texas, USA.
Flyak AI; Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, Tennessee, USA.
Kuzmina N; Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.; Galveston National Laboratory, Galveston, Texas, USA.
Ksiazek TG; Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.; Galveston National Laboratory, Galveston, Texas, USA.
Crowe JE Jr; Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, Tennessee, USA.; Vanderbilt Vaccine Center, Vanderbilt University, Nashville, Tennessee, USA.; Department of Pediatrics, Vanderbilt University, Nashville, Tennessee, USA.
Bukreyev A; Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA .; Galveston National Laboratory, Galveston, Texas, USA.
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Źródło :
Journal of virology [J Virol] 2016 Mar 28; Vol. 90 (8), pp. 3890-3901. Date of Electronic Publication: 2016 Mar 28 (Print Publication: 2016).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Monoclonal/*immunology
Antibodies, Viral/*immunology
Filoviridae/*immunology
Animals ; Antibodies, Neutralizing/immunology ; Chlorocebus aethiops ; Filoviridae/genetics ; Humans ; Recombinant Proteins/genetics ; Recombinant Proteins/immunology ; Reverse Genetics ; Vero Cells ; Viral Envelope Proteins/genetics ; Viral Envelope Proteins/immunology
Czasopismo naukowe
Tytuł :
Innate Immune Responses of Bat and Human Cells to Filoviruses: Commonalities and Distinctions.
Autorzy :
Kuzmin IV; Department of Pathology, The University of Texas Medical Branch, Galveston, Texas, USA.; Galveston National Laboratory, The University of Texas Medical Branch, Galveston, Texas, USA.
Schwarz TM; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Ilinykh PA; Department of Pathology, The University of Texas Medical Branch, Galveston, Texas, USA.; Galveston National Laboratory, The University of Texas Medical Branch, Galveston, Texas, USA.
Jordan I; ProBioGen AG, Berlin, Germany.
Ksiazek TG; Department of Pathology, The University of Texas Medical Branch, Galveston, Texas, USA.; Galveston National Laboratory, The University of Texas Medical Branch, Galveston, Texas, USA.; Department Microbiology & Immunology, The University of Texas Medical Branch, Galveston, Texas, USA.
Sachidanandam R; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Basler CF; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Bukreyev A; Department of Pathology, The University of Texas Medical Branch, Galveston, Texas, USA .; Galveston National Laboratory, The University of Texas Medical Branch, Galveston, Texas, USA.; Department Microbiology & Immunology, The University of Texas Medical Branch, Galveston, Texas, USA.
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Źródło :
Journal of virology [J Virol] 2017 Mar 29; Vol. 91 (8). Date of Electronic Publication: 2017 Mar 29 (Print Publication: 2017).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Immunity, Innate*
Ebolavirus/*immunology
Marburgvirus/*immunology
Animals ; Cell Line ; Chiroptera ; Ebolavirus/physiology ; Humans ; Immune Tolerance ; Interferons/analysis ; Marburgvirus/physiology ; Protein Domains ; Viral Proteins/immunology ; Virus Replication
Czasopismo naukowe
Tytuł :
The Marburgvirus-Neutralizing Human Monoclonal Antibody MR191 Targets a Conserved Site to Block Virus Receptor Binding.
Autorzy :
King LB; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Fusco ML; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Flyak AI; Departments of Pediatrics, Pathology, Microbiology, and Immunology, and the Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Ilinykh PA; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA; Galveston National Laboratory, Galveston, TX 77550, USA.
Huang K; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA; Galveston National Laboratory, Galveston, TX 77550, USA.
Gunn B; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA.
Kirchdoerfer RN; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Hastie KM; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Sangha AK; Department of Chemistry and Center for Structural Biology, Vanderbilt University, Nashville, TN 37232, USA.
Meiler J; Department of Chemistry and Center for Structural Biology, Vanderbilt University, Nashville, TN 37232, USA.
Alter G; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA.
Bukreyev A; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA; Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA; Galveston National Laboratory, Galveston, TX 77550, USA.
Crowe JE Jr; Departments of Pediatrics, Pathology, Microbiology, and Immunology, and the Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Saphire EO; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA; Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: .
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Źródło :
Cell host & microbe [Cell Host Microbe] 2018 Jan 10; Vol. 23 (1), pp. 101-109.e4.
Typ publikacji :
Journal Article
MeSH Terms :
Antibodies, Monoclonal/*immunology
Antibodies, Neutralizing/*immunology
Antibodies, Viral/*immunology
Marburgvirus/*immunology
Receptors, Virus/*immunology
Receptors, Virus/*ultrastructure
Viral Fusion Proteins/*immunology
Viral Fusion Proteins/*ultrastructure
Agrobacterium tumefaciens ; Animals ; Antibodies, Monoclonal/ultrastructure ; Binding Sites/immunology ; Carrier Proteins/immunology ; Cell Line ; Chlorocebus aethiops ; Crystallography, X-Ray ; Drosophila melanogaster ; Humans ; Intracellular Signaling Peptides and Proteins ; Marburgvirus/metabolism ; Membrane Glycoproteins/immunology ; Tobacco ; Vero Cells ; Viral Envelope Proteins/genetics ; Viral Envelope Proteins/immunology ; Virus Attachment
Czasopismo naukowe
Tytuł :
Corrigendum: Ebola VP40 in Exosomes Can Cause Immune Cell Dysfunction.
Autorzy :
Pleet ML; Laboratory of Molecular Virology, School of Systems Biology, George Mason University, Manassas, VA, USA.
Mathiesen A; Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, VA, USA.
DeMarino C; Laboratory of Molecular Virology, School of Systems Biology, George Mason University, Manassas, VA, USA.
Akpamagbo YA; Laboratory of Molecular Virology, School of Systems Biology, George Mason University, Manassas, VA, USA.
Barclay RA; Laboratory of Molecular Virology, School of Systems Biology, George Mason University, Manassas, VA, USA.
Schwab A; Laboratory of Molecular Virology, School of Systems Biology, George Mason University, Manassas, VA, USA.
Iordanskiy S; Department of Microbiology, Immunology and Tropical Medicine, Research Center for Neglected Diseases of Poverty, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Sampey GC; Laboratory of Molecular Virology, School of Systems Biology, George Mason University, Manassas, VA, USA.; Department of Medicine, University of North Carolina HIV Cure Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
Lepene B; Ceres Nanosciences Inc., Manassas, VA, USA.
Ilinykh PA; Departments of Pathology, University of Texas Medical Branch at Galveston, Galveston, TX, USA.
Bukreyev A; Departments of Pathology, University of Texas Medical Branch at Galveston, Galveston, TX, USA.; Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, TX, USA.; Galveston National Laboratory, University of Texas Medical Branch at Galveston, Galveston, TX, USA.
Nekhai S; Department of Medicine, Center for Sickle Cell Disease, Howard University, Washington, DC, USA.
Aman MJ; Integrated BioTherapeutics, Inc., Gaithersburg, MD, USA.
Kashanchi F; Laboratory of Molecular Virology, School of Systems Biology, George Mason University, Manassas, VA, USA.
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Źródło :
Frontiers in microbiology [Front Microbiol] 2018 Apr 17; Vol. 9, pp. 692. Date of Electronic Publication: 2018 Apr 17 (Print Publication: 2018).
Typ publikacji :
Published Erratum
Tytuł :
Broadly neutralizing antibodies from human survivors target a conserved site in the Ebola virus glycoprotein HR2-MPER region.
Autorzy :
Flyak AI; Department of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, TN, USA.; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Kuzmina N; Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA.; Galveston National Laboratory, Galveston, TX, USA.
Murin CD; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA, USA.
Bryan C; Integral Molecular, Inc., Philadelphia, PA, USA.
Davidson E; Integral Molecular, Inc., Philadelphia, PA, USA.
Gilchuk P; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Gulka CP; Department of Chemistry, Vanderbilt University Medical Center, Nashville, TN, USA.
Ilinykh PA; Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA.; Galveston National Laboratory, Galveston, TX, USA.
Shen X; Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA.; Galveston National Laboratory, Galveston, TX, USA.
Huang K; Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA.; Galveston National Laboratory, Galveston, TX, USA.
Ramanathan P; Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA.; Galveston National Laboratory, Galveston, TX, USA.
Turner H; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.
Fusco ML; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA, USA.
Lampley R; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Kose N; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA.
King H; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Sapparapu G; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Doranz BJ; Integral Molecular, Inc., Philadelphia, PA, USA.
Ksiazek TG; Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA.; Galveston National Laboratory, Galveston, TX, USA.
Wright DW; Department of Chemistry, Vanderbilt University Medical Center, Nashville, TN, USA.
Saphire EO; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA, USA.; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA.
Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.
Bukreyev A; Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA. .; Galveston National Laboratory, Galveston, TX, USA. .; Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX, USA. .
Crowe JE Jr; Department of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, TN, USA. .; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA. .; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA. .
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Źródło :
Nature microbiology [Nat Microbiol] 2018 Jun; Vol. 3 (6), pp. 670-677. Date of Electronic Publication: 2018 May 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Antibodies, Neutralizing/*pharmacology
Ebolavirus/*immunology
Epitopes/*immunology
Hemorrhagic Fever, Ebola/*immunology
Membrane Glycoproteins/*chemistry
Animals ; Antibodies, Neutralizing/metabolism ; Antibodies, Viral/metabolism ; Antibodies, Viral/pharmacology ; Binding Sites/drug effects ; Chlorocebus aethiops ; Cross Reactions ; Ferrets ; Guinea Pigs ; Hemorrhagic Fever, Ebola/metabolism ; Humans ; Membrane Glycoproteins/immunology ; Membrane Glycoproteins/metabolism ; Mice ; Models, Molecular ; Protein Binding ; Rabbits ; Vero Cells ; Viral Proteins/chemistry ; Viral Proteins/metabolism
Czasopismo naukowe
Tytuł :
Antibody-Dependent Enhancement of Ebola Virus Infection by Human Antibodies Isolated from Survivors.
Autorzy :
Kuzmina NA; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA; Galveston National Laboratory, Galveston, TX 77550, USA.
Younan P; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA; Galveston National Laboratory, Galveston, TX 77550, USA.
Gilchuk P; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Santos RI; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA; Galveston National Laboratory, Galveston, TX 77550, USA.
Flyak AI; Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN 37232, USA.
Ilinykh PA; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA; Galveston National Laboratory, Galveston, TX 77550, USA.
Huang K; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA; Galveston National Laboratory, Galveston, TX 77550, USA.
Lubaki NM; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA; Galveston National Laboratory, Galveston, TX 77550, USA.
Ramanathan P; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA; Galveston National Laboratory, Galveston, TX 77550, USA.
Crowe JE Jr; Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Electronic address: .
Bukreyev A; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA; Galveston National Laboratory, Galveston, TX 77550, USA; Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA. Electronic address: .
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Źródło :
Cell reports [Cell Rep] 2018 Aug 14; Vol. 24 (7), pp. 1802-1815.e5.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Antibody-Dependent Enhancement*
Antibodies, Monoclonal/*pharmacology
Antibodies, Neutralizing/*pharmacology
Antibodies, Viral/*pharmacology
Hemorrhagic Fever, Ebola/*virology
Marburg Virus Disease/*virology
Animals ; Antibodies, Monoclonal/isolation & purification ; Antibodies, Neutralizing/isolation & purification ; Antibodies, Viral/isolation & purification ; Ebolavirus/drug effects ; Ebolavirus/genetics ; Ebolavirus/immunology ; Ebolavirus/pathogenicity ; Epitopes/genetics ; Epitopes/immunology ; Gene Expression ; Genes, Reporter ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; Hemorrhagic Fever, Ebola/immunology ; Hemorrhagic Fever, Ebola/mortality ; Hemorrhagic Fever, Ebola/therapy ; Humans ; Immune Sera/chemistry ; Immunoglobulin Fc Fragments/chemistry ; Immunoglobulin Fc Fragments/genetics ; Marburg Virus Disease/immunology ; Marburg Virus Disease/mortality ; Marburg Virus Disease/therapy ; Marburgvirus/drug effects ; Marburgvirus/genetics ; Marburgvirus/pathogenicity ; Mice ; Mice, Inbred BALB C ; Monocytes/drug effects ; Monocytes/immunology ; Monocytes/virology ; Primary Cell Culture ; Receptors, IgG/genetics ; Receptors, IgG/immunology ; Survival Analysis ; Survivors ; THP-1 Cells ; Viral Envelope Proteins/genetics ; Viral Envelope Proteins/immunology
Czasopismo naukowe
Tytuł :
Multifunctional Pan-ebolavirus Antibody Recognizes a Site of Broad Vulnerability on the Ebolavirus Glycoprotein.
Autorzy :
Gilchuk P; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Kuzmina N; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA; Galveston National Laboratory, Galveston, TX 77550, USA.
Ilinykh PA; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA; Galveston National Laboratory, Galveston, TX 77550, USA.
Huang K; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA; Galveston National Laboratory, Galveston, TX 77550, USA.
Gunn BM; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
Bryan A; Integral Molecular, Inc., Philadelphia, PA 19104, USA.
Davidson E; Integral Molecular, Inc., Philadelphia, PA 19104, USA.
Doranz BJ; Integral Molecular, Inc., Philadelphia, PA 19104, USA.
Turner HL; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Fusco ML; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Bramble MS; Department of Epidemiology, Jonathan and Karin Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Genetic Medicine Research, Children's Research Institute, Children's National Medical Center, Washington, DC 20010, USA.
Hoff NA; Department of Epidemiology, Jonathan and Karin Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Binshtein E; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232, USA.
Kose N; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Flyak AI; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Flinko R; Division of Vaccine Research, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Orlandi C; Division of Vaccine Research, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Carnahan R; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Parrish EH; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Sevy AM; Chemical and Physical Biology Program, Vanderbilt University, Nashville, TN 37232, USA.
Bombardi RG; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Singh PK; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232, USA.
Mukadi P; Institut Nationale de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo.
Muyembe-Tamfum JJ; Institut Nationale de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo.
Ohi MD; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232, USA.
Saphire EO; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Lewis GK; Division of Vaccine Research, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Alter G; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Rimoin AW; Department of Epidemiology, Jonathan and Karin Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Bukreyev A; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA; Galveston National Laboratory, Galveston, TX 77550, USA; Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA. Electronic address: .
Crowe JE Jr; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Chemical and Physical Biology Program, Vanderbilt University, Nashville, TN 37232, USA; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Electronic address: .
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Źródło :
Immunity [Immunity] 2018 Aug 21; Vol. 49 (2), pp. 363-374.e10. Date of Electronic Publication: 2018 Jul 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Antibodies, Monoclonal/*immunology
Antibodies, Monoclonal/*pharmacology
Antibodies, Neutralizing/*immunology
Antibodies, Neutralizing/*pharmacology
Antibodies, Viral/*immunology
Antibodies, Viral/*pharmacology
Ebolavirus/*immunology
Glycoproteins/*immunology
Hemorrhagic Fever, Ebola/*immunology
3T3 Cells ; Adult ; Animals ; CHO Cells ; Cell Line ; Chlorocebus aethiops ; Cricetulus ; Disease Models, Animal ; Drosophila ; Female ; Ferrets ; Guinea Pigs ; Hemorrhagic Fever, Ebola/prevention & control ; Hemorrhagic Fever, Ebola/virology ; Humans ; Immunoglobulin G/immunology ; Jurkat Cells ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Knockout ; THP-1 Cells ; Vero Cells
Czasopismo naukowe
Tytuł :
Phosphorylated VP30 of Marburg Virus Is a Repressor of Transcription
Autorzy :
Tigabu B; Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
Ramanathan P; Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
Ivanov A; Center for Sickle Cell Disease, Howard University, Washington, DC, USA.
Lin X; Center for Sickle Cell Disease, Howard University, Washington, DC, USA.
Ilinykh PA; Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
Parry CS; Center for Sickle Cell Disease, Howard University, Washington, DC, USA.
Freiberg AN; Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.; Galveston National Laboratory, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
Nekhai S; Center for Sickle Cell Disease, Howard University, Washington, DC, USA .; Department of Medicine, Howard University, Washington, DC, USA.
Bukreyev A; Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA .; Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.; Galveston National Laboratory, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
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Źródło :
Journal of virology [J Virol] 2018 Oct 12; Vol. 92 (21). Date of Electronic Publication: 2018 Oct 12 (Print Publication: 2018).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Marburgvirus/*growth & development
Nucleoproteins/*metabolism
Viral Proteins/*metabolism
Viral Regulatory and Accessory Proteins/*metabolism
Virus Replication/*physiology
Amino Acid Sequence ; Animals ; Cell Line ; Chlorocebus aethiops ; Genome, Viral/genetics ; HEK293 Cells ; Humans ; Indoles/pharmacology ; Marburgvirus/genetics ; Mass Spectrometry ; Phosphorylation ; RNA, Viral/genetics ; Transcription, Genetic/genetics ; Urea/analogs & derivatives ; Urea/pharmacology ; Vero Cells ; Viral Proteins/genetics
Czasopismo naukowe
Tytuł :
Ebolavirus Chimerization for the Development of a Mouse Model for Screening of Bundibugyo-Specific Antibodies.
Autorzy :
Ilinykh PA; Department of Pathology, University of Texas Medical Branch, Galveston.; Galveston National Laboratory, University of Texas Medical Branch, Galveston.
Graber J; Galveston National Laboratory, University of Texas Medical Branch, Galveston.
Kuzmina NA; Department of Pathology, University of Texas Medical Branch, Galveston.; Galveston National Laboratory, University of Texas Medical Branch, Galveston.
Huang K; Department of Pathology, University of Texas Medical Branch, Galveston.; Galveston National Laboratory, University of Texas Medical Branch, Galveston.
Ksiazek TG; Department of Pathology, University of Texas Medical Branch, Galveston.; Galveston National Laboratory, University of Texas Medical Branch, Galveston.
Crowe JE Jr; Vanderbilt Vaccine Center, Vanderbilt University Medical Center.; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center.; Chemical and Physical Biology Program, Vanderbilt University.; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee.
Bukreyev A; Department of Pathology, University of Texas Medical Branch, Galveston.; Galveston National Laboratory, University of Texas Medical Branch, Galveston.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston.
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Źródło :
The Journal of infectious diseases [J Infect Dis] 2018 Nov 22; Vol. 218 (suppl_5), pp. S418-S422.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Antibodies, Monoclonal/*immunology
Antibodies, Viral/*immunology
Ebolavirus/*immunology
Animals ; Antibodies, Neutralizing/immunology ; Chlorocebus aethiops ; Disease Models, Animal ; Hemorrhagic Fever, Ebola/immunology ; Mice ; Mice, Knockout ; Vero Cells ; Viral Envelope Proteins/immunology
Czasopismo naukowe
Tytuł :
Structural basis of broad ebolavirus neutralization by a human survivor antibody.
Autorzy :
West BR; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Wec AZ; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.; Adimab LLC, Lebanon, NH, USA.
Moyer CL; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; Mapp Biopharmaceutical, San Diego, CA, USA.
Fusco ML; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Ilinykh PA; Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA.; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA.
Huang K; Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA.; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA.
Wirchnianski AS; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.
James RM; Division of Virology, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA.
Herbert AS; Division of Virology, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA.
Hui S; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Goodwin E; Adimab LLC, Lebanon, NH, USA.
Howell KA; Integrated Biotherapeutics, Rockville, MD, USA.
Kailasan S; Integrated Biotherapeutics, Rockville, MD, USA.
Aman MJ; Integrated Biotherapeutics, Rockville, MD, USA.
Walker LM; Adimab LLC, Lebanon, NH, USA.
Dye JM; Division of Virology, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA.
Bukreyev A; Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA.; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA.; Department of Immunology and Microbiology, University of Texas Medical Branch, Galveston, TX, USA.
Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA. .
Saphire EO; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA. .; Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA. .
Pokaż więcej
Źródło :
Nature structural & molecular biology [Nat Struct Mol Biol] 2019 Mar; Vol. 26 (3), pp. 204-212. Date of Electronic Publication: 2019 Mar 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Antibodies, Neutralizing/*immunology
Antibodies, Viral/*immunology
Ebolavirus/*immunology
Viral Fusion Proteins/*immunology
Antibodies, Monoclonal/immunology ; Antibody Affinity/immunology ; Crystallography, X-Ray ; Humans ; Protein Structure, Tertiary ; Survivors
Czasopismo naukowe

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