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Tytuł :
iPSC-Based Compound Screening and In Vitro Trials Identify a Synergistic Anti-amyloid β Combination for Alzheimer's Disease.
Autorzy :
Kondo T; Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan; Drug-Discovery Cellular Basis Development Team, RIKEN BioResource Center, Kyoto 606-8507, Japan.
Imamura K; Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan; Drug-Discovery Cellular Basis Development Team, RIKEN BioResource Center, Kyoto 606-8507, Japan.
Funayama M; Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan.
Tsukita K; Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan.
Miyake M; Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan; Drug-Discovery Cellular Basis Development Team, RIKEN BioResource Center, Kyoto 606-8507, Japan.
Ohta A; Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan.
Woltjen K; Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan; Hakubi Center for Advanced Research, Kyoto University, Kyoto 606-8501, Japan.
Nakagawa M; Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan.
Asada T; Department of Psychiatry, Division of Clinical Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan.
Arai T; Department of Psychiatry, Division of Clinical Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan.
Kawakatsu S; Department of Neuropsychiatry, Aizu Medical Center, Fukushima Medical University, Fukushima 969-3492, Japan.
Izumi Y; Department of Clinical Neuroscience, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, Japan.
Kaji R; Department of Clinical Neuroscience, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, Japan.
Iwata N; Department of Genome-based Drug Discovery, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8521, Japan; Unit for Dementia Research and Drug Discovery, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8521, Japan.
Inoue H; Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan; Drug-Discovery Cellular Basis Development Team, RIKEN BioResource Center, Kyoto 606-8507, Japan. Electronic address: .
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Źródło :
Cell reports [Cell Rep] 2017 Nov 21; Vol. 21 (8), pp. 2304-2312.
Typ publikacji :
Journal Article
MeSH Terms :
Alzheimer Disease/*pathology
Amyloid beta-Peptides/*immunology
Induced Pluripotent Stem Cells/*cytology
Neurons/*pathology
Alzheimer Disease/drug therapy ; Alzheimer Disease/immunology ; Amyloid beta-Protein Precursor/immunology ; Drug Evaluation, Preclinical/methods ; Humans
Czasopismo naukowe
Tytuł :
Proteasome impairment in neural cells derived from HMSN-P patient iPSCs.
Autorzy :
Murakami N; Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, 606-8507, Japan.; Department of Clinical Neuroscience, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, 770-8503, Japan.
Imamura K; Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, 606-8507, Japan.
Izumi Y; Department of Clinical Neuroscience, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, 770-8503, Japan.
Egawa N; Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, 606-8507, Japan.
Tsukita K; Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, 606-8507, Japan.
Enami T; Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, 606-8507, Japan.
Yamamoto T; Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, 606-8507, Japan.
Kawarai T; Department of Clinical Neuroscience, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, 770-8503, Japan.
Kaji R; Department of Clinical Neuroscience, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, 770-8503, Japan.
Inoue H; Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, 606-8507, Japan. .
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Źródło :
Molecular brain [Mol Brain] 2017 Feb 15; Vol. 10 (1), pp. 7. Date of Electronic Publication: 2017 Feb 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hereditary Sensory and Motor Neuropathy/*metabolism
Hereditary Sensory and Motor Neuropathy/*pathology
Induced Pluripotent Stem Cells/*metabolism
Neurons/*metabolism
Neurons/*pathology
Proteasome Endopeptidase Complex/*metabolism
Aged ; Aged, 80 and over ; Cell Differentiation ; Clone Cells ; Female ; Humans ; Male ; Middle Aged ; Motor Neurons/pathology ; Mutation/genetics ; Phenotype ; Proteins/genetics ; Spinal Cord/pathology
Czasopismo naukowe
Tytuł :
Localization of Drebrin: Light Microscopy Study.
Autorzy :
Shirao T; Department of Neurobiology and Behavior, Gunma University Graduate School of Medicine, Maebashi, Gunma, 371-8511, Japan. .
Koganezawa N; Department of Neurobiology and Behavior, Gunma University Graduate School of Medicine, Maebashi, Gunma, 371-8511, Japan.
Yamazaki H; Department of Neurobiology and Behavior, Gunma University Graduate School of Medicine, Maebashi, Gunma, 371-8511, Japan.
Hanamura K; Department of Neurobiology and Behavior, Gunma University Graduate School of Medicine, Maebashi, Gunma, 371-8511, Japan.
Imamura K; Department of Systems Life Engineering, Maebashi Institute of Technology, Maebashi, Japan.
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Źródło :
Advances in experimental medicine and biology [Adv Exp Med Biol] 2017; Vol. 1006, pp. 105-118.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Neuronal Plasticity*
Neurons/*metabolism
Neuropeptides/*isolation & purification
Visual Cortex/*diagnostic imaging
Animals ; Cats ; Chick Embryo ; Chickens/metabolism ; Dendritic Spines/chemistry ; Dendritic Spines/metabolism ; Dendritic Spines/ultrastructure ; Microscopy ; Neurons/chemistry ; Neurons/ultrastructure ; Neuropeptides/biosynthesis ; Neuropeptides/metabolism ; Rats ; Visual Cortex/chemistry ; Visual Cortex/metabolism
Czasopismo naukowe
Tytuł :
Calcium dysregulation contributes to neurodegeneration in FTLD patient iPSC-derived neurons.
Autorzy :
Imamura K; Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.
Sahara N; Department of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.
Kanaan NM; Department of Translational Science and Molecular Medicine, College of Human Medicine, Michigan State University, Grand Rapids, MI, USA.
Tsukita K; Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.
Kondo T; Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.
Kutoku Y; Department of Neurology, Kawasaki Medical School, Kurashiki, Okayama, Japan.
Ohsawa Y; Department of Neurology, Kawasaki Medical School, Kurashiki, Okayama, Japan.
Sunada Y; Department of Neurology, Kawasaki Medical School, Kurashiki, Okayama, Japan.
Kawakami K; Division of Molecular and Developmental Biology, National Institute of Genetics and Department of Genetics, SOKENDAI (The Graduate University for Advanced Studies), Mishima, Shizuoka, Japan.
Hotta A; Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.
Yawata S; Department of Biological Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Watanabe D; Department of Biological Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Hasegawa M; Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Trojanowski JQ; Center for Neurodegenerative Disease Research, Institute on Aging, University of Pennsylvania Perelman School of Medicine, Philadelphia, USA.
Lee VM; Center for Neurodegenerative Disease Research, Institute on Aging, University of Pennsylvania Perelman School of Medicine, Philadelphia, USA.
Suhara T; Department of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.
Higuchi M; Department of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.
Inoue H; Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.
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Źródło :
Scientific reports [Sci Rep] 2016 Oct 10; Vol. 6, pp. 34904. Date of Electronic Publication: 2016 Oct 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium/*metabolism
Frontotemporal Lobar Degeneration/*physiopathology
Induced Pluripotent Stem Cells/*drug effects
Induced Pluripotent Stem Cells/*pathology
Neurons/*drug effects
Neurons/*pathology
Cell Survival ; Cells, Cultured ; Humans ; Models, Biological ; Protein Folding ; tau Proteins/genetics ; tau Proteins/metabolism
Czasopismo naukowe
Tytuł :
Cytoplasmic aggregates of dynactin in iPSC-derived tyrosine hydroxylase-positive neurons from a patient with Perry syndrome.
Autorzy :
Mishima T; Center for iPS Cell Research and Application (CiRA), Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan; Department of Neurology, Fukuoka University School of Medicine, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan. Electronic address: .
Ishikawa T; Center for iPS Cell Research and Application (CiRA), Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan; Sumitomo Dainippon Pharma, 3-1-98 Kasugadenaka, Konohana-ku, Osaka, 554-0022, Japan. Electronic address: .
Imamura K; Center for iPS Cell Research and Application (CiRA), Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan. Electronic address: keiko.imamura@cira.kyoto-u.ac.jp.
Kondo T; Center for iPS Cell Research and Application (CiRA), Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan. Electronic address: .
Koshiba Y; Center for iPS Cell Research and Application (CiRA), Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan; Department of Neurology, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan. Electronic address: .
Takahashi R; Department of Neurology, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan. Electronic address: .
Takahashi J; Center for iPS Cell Research and Application (CiRA), Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan. Electronic address: .
Watanabe A; Department of Neurology, National Omuta Hospital, 1044-1 Tachibana, Omuta, Fukuoka, 837-0911, Japan. Electronic address: .
Fujii N; Department of Neurology, National Omuta Hospital, 1044-1 Tachibana, Omuta, Fukuoka, 837-0911, Japan. Electronic address: .
Tsuboi Y; Department of Neurology, Fukuoka University School of Medicine, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan. Electronic address: .
Inoue H; Center for iPS Cell Research and Application (CiRA), Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan. Electronic address: .
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Źródło :
Parkinsonism & related disorders [Parkinsonism Relat Disord] 2016 Sep; Vol. 30, pp. 67-72. Date of Electronic Publication: 2016 Jun 15.
Typ publikacji :
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cytoplasm/*metabolism
Dynactin Complex/*metabolism
Hypoventilation/*metabolism
Induced Pluripotent Stem Cells/*enzymology
Microtubule-Associated Proteins/*genetics
Neurons/*enzymology
Parkinsonian Disorders/*metabolism
Tyrosine 3-Monooxygenase/*metabolism
Depression/metabolism ; Depression/pathology ; Humans ; Hypoventilation/pathology ; Male ; Middle Aged ; Mutation/genetics ; Parkinsonian Disorders/pathology
SCR Disease Name :
Perry Syndrome
Czasopismo naukowe
Tytuł :
Involvement of endoplasmic reticulum stress on neuronal cell death in the lateral geniculate nucleus in the monkey glaucoma model.
Autorzy :
Ito Y; Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, 1-25-4 Daigaku-Nishi, Gifu 501-1196, Japan.
Shimazawa M
Inokuchi Y
Yamanaka H
Tsuruma K
Imamura K
Onoe H
Watanabe Y
Aihara M
Araie M
Hara H
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Źródło :
The European journal of neuroscience [Eur J Neurosci] 2011 Mar; Vol. 33 (5), pp. 843-55. Date of Electronic Publication: 2011 Jan 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Models, Animal*
Geniculate Bodies*/cytology
Geniculate Bodies*/pathology
Geniculate Bodies*/physiology
Stress, Physiological*
Cell Death/*physiology
Endoplasmic Reticulum/*metabolism
Glaucoma/*physiopathology
Neurons/*physiology
Animals ; Glaucoma/pathology ; Humans ; In Situ Nick-End Labeling ; Intraocular Pressure/physiology ; Macaca fascicularis ; Male ; Neurons/cytology ; Optic Nerve/cytology ; Optic Nerve/pathology ; Optic Nerve/physiology ; Retina/cytology ; Retina/pathology ; Retina/physiology ; Transcription Factor CHOP/metabolism
Czasopismo naukowe
Tytuł :
Pramipexole has astrocyte-mediated neuroprotective effects against lactacystin toxicity.
Autorzy :
Imamura K; Department of Neurology, Institute of Neurological Sciences, Tottori University, Faculty of Medicine, Yonago, Tottori, Japan. />Takeshima T
Nakaso K
Ito S
Nakashima K
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Źródło :
Neuroscience letters [Neurosci Lett] 2008 Aug 01; Vol. 440 (2), pp. 97-102. Date of Electronic Publication: 2008 May 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Acetylcysteine/*analogs & derivatives
Astrocytes/*drug effects
Benzothiazoles/*pharmacology
Neurons/*drug effects
Acetylcysteine/toxicity ; Animals ; Astrocytes/cytology ; Astrocytes/metabolism ; Brain-Derived Neurotrophic Factor/metabolism ; Cell Death/drug effects ; Cell Line, Tumor ; Cells, Cultured ; Cysteine Proteinase Inhibitors/toxicity ; Dopamine Agonists/pharmacology ; Dose-Response Relationship, Drug ; Enzyme-Linked Immunosorbent Assay ; Female ; Microtubule-Associated Proteins/metabolism ; Neurons/cytology ; Neurons/metabolism ; Pramipexole ; Pregnancy ; Rats ; Rats, Sprague-Dawley ; Receptors, Dopamine D1/agonists ; Receptors, Dopamine D2/agonists ; Tyrosine 3-Monooxygenase/metabolism
Czasopismo naukowe
Tytuł :
Homocysteine is toxic for dopaminergic neurons in primary mesencephalic culture.
Autorzy :
Imamura K; Department of Neurology, Institute of Neurological Science, Tottori University, Faculty of Medicine, Yonago, Tottori, Japan. />Takeshima T
Nakaso K
Nakashima K
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Źródło :
Neuroreport [Neuroreport] 2007 Aug 27; Vol. 18 (13), pp. 1319-22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dopamine/*metabolism
Homocysteine/*toxicity
Mesencephalon/*cytology
Neurons/*drug effects
Neurons/*metabolism
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/pharmacology ; Animals ; Antipsychotic Agents/pharmacology ; Cells, Cultured ; Dose-Response Relationship, Drug ; Drug Synergism ; Embryo, Mammalian ; Female ; Microtubule-Associated Proteins/metabolism ; Neurotoxins/pharmacokinetics ; Pregnancy ; Rats ; Rats, Sprague-Dawley ; Reserpine/pharmacology ; Tyrosine 3-Monooxygenase/metabolism
Czasopismo naukowe
Tytuł :
D-beta-hydroxybutyrate protects dopaminergic SH-SY5Y cells in a rotenone model of Parkinson's disease.
Autorzy :
Imamura K; Department of Neurology, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, Yonago, Japan. />Takeshima T
Kashiwaya Y
Nakaso K
Nakashima K
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Źródło :
Journal of neuroscience research [J Neurosci Res] 2006 Nov 01; Vol. 84 (6), pp. 1376-84.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
3-Hydroxybutyric Acid/*pharmacology
Dopamine/*physiology
Neurons/*pathology
Parkinson Disease, Secondary/*chemically induced
Parkinson Disease, Secondary/*prevention & control
Rotenone/*antagonists & inhibitors
Rotenone/*toxicity
Uncoupling Agents/*antagonists & inhibitors
Uncoupling Agents/*toxicity
Caspase 3/metabolism ; Caspase 9/metabolism ; Cell Line, Tumor ; Cell Survival/drug effects ; Fluorescent Dyes ; Humans ; Indoles ; Ketone Bodies/metabolism ; L-Lactate Dehydrogenase/metabolism ; Membrane Potentials/drug effects ; Neurotoxins/toxicity ; Nitro Compounds/toxicity ; Oxidation-Reduction ; Parkinson Disease, Secondary/pathology ; Propionates/toxicity ; Succinates/pharmacology
Czasopismo naukowe
Tytuł :
Cellular and subcellular localization of alpha-1 adrenoceptors in the rat visual cortex.
Autorzy :
Nakadate K; Department of Histology and Neurobiology, Dokkyo Medical University School of Medicine, 880 Kitakobayashi, Mibu-machi, Tochigi 321-0293, Japan.
Imamura K
Watanabe Y
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Źródło :
Neuroscience [Neuroscience] 2006 Sep 15; Vol. 141 (4), pp. 1783-92. Date of Electronic Publication: 2006 Jun 22.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Neurons/*metabolism
Neurons/*ultrastructure
Receptors, Adrenergic, alpha-1/*metabolism
Visual Cortex/*cytology
Visual Cortex/*metabolism
2',3'-Cyclic-Nucleotide Phosphodiesterases/metabolism ; Animals ; Blotting, Western/methods ; Diagnostic Imaging/methods ; Immunohistochemistry/methods ; Male ; Microscopy, Immunoelectron/methods ; Microtubule-Associated Proteins/metabolism ; Nerve Tissue Proteins/metabolism ; Rats ; Rats, Long-Evans ; Subcellular Fractions/metabolism ; Subcellular Fractions/ultrastructure
Czasopismo naukowe
Tytuł :
Cytokine production of activated microglia and decrease in neurotrophic factors of neurons in the hippocampus of Lewy body disease brains.
Autorzy :
Imamura K; Department of Neurology, Okazaki City Hospital, 3-1 Goshoai, Kouryuuji-cho, 444-8553, Okazaki, Aichi, Japan. />Hishikawa N
Ono K
Suzuki H
Sawada M
Nagatsu T
Yoshida M
Hashizume Y
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Źródło :
Acta neuropathologica [Acta Neuropathol] 2005 Feb; Vol. 109 (2), pp. 141-50. Date of Electronic Publication: 2004 Dec 24.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Cytokines/*metabolism
Hippocampus/*pathology
Lewy Body Disease/*metabolism
Microglia/*metabolism
Nerve Growth Factors/*metabolism
Neurons/*metabolism
Aged ; Aged, 80 and over ; Analysis of Variance ; Case-Control Studies ; Cell Count/methods ; Cytokines/genetics ; Female ; Glial Fibrillary Acidic Protein/metabolism ; Hippocampus/metabolism ; Humans ; Immunohistochemistry/methods ; Male ; Nerve Growth Factors/genetics ; Nerve Tissue Proteins/metabolism ; RNA, Messenger/biosynthesis ; Reverse Transcriptase Polymerase Chain Reaction/methods ; Synucleins
Czasopismo naukowe
Tytuł :
Visual stimulation-induced phosphorylation of neurofilament-L in the visual cortex of dark-reared rats.
Autorzy :
Hashimoto R; Division of Psychiatry and Behavioral Proteomics, Department of Post-Genomics and Diseases, Course of Advanced Medicine, Osaka University, Graduate School of Medicine, Suita-shi, Osaka, 565-0871, Japan.
Nakamura Y
Imamura K
Nakadate K
Kashiwagi Y
Matsumoto N
Takeda M
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Źródło :
The European journal of neuroscience [Eur J Neurosci] 2001 Oct; Vol. 14 (8), pp. 1237-45.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Darkness*
Photic Stimulation*
Neurofilament Proteins/*metabolism
Neuronal Plasticity/*physiology
Neurons/*metabolism
Sensory Deprivation/*physiology
Visual Cortex/*metabolism
Amino Acid Sequence/physiology ; Animals ; Antibody Specificity/immunology ; Cytoskeleton/metabolism ; Immunohistochemistry ; Neurons/cytology ; Phosphorylation ; Rats ; Rats, Long-Evans ; Serine/metabolism ; Visual Cortex/cytology ; Visual Cortex/growth & development
Czasopismo naukowe
Tytuł :
Selective suppression of horizontal propagation in rat visual cortex by norepinephrine.
Autorzy :
Kobayashi M; Department of Neuroscience, Osaka Bioscience Institute, 6-2-4 Furuedai, Suita-shi, Osaka 565-0874, Japan.
Imamura K
Sugai T
Onoda N
Yamamoto M
Komai S
Watanabe Y
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Źródło :
The European journal of neuroscience [Eur J Neurosci] 2000 Jan; Vol. 12 (1), pp. 264-72.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Neurons/*physiology
Norepinephrine/*pharmacology
Pyramidal Cells/*physiology
Visual Cortex/*physiology
2-Amino-5-phosphonovalerate/pharmacology ; 6-Cyano-7-nitroquinoxaline-2,3-dione/pharmacology ; Animals ; Clonidine/pharmacology ; Image Processing, Computer-Assisted ; In Vitro Techniques ; Isoproterenol/pharmacology ; Membrane Potentials/drug effects ; Membrane Potentials/physiology ; Neurons/drug effects ; Patch-Clamp Techniques ; Phenylephrine/pharmacology ; Pyramidal Cells/drug effects ; Rats ; Rats, Long-Evans ; Reaction Time ; Tetrodotoxin/pharmacology ; Visual Cortex/drug effects
Czasopismo naukowe
Tytuł :
A novel near infra-red spectrophotometry system using microprobes: its evaluation and application for monitoring neuronal activity in the visual cortex.
Autorzy :
Imamura K; Subfemtomole Biorecognition Project, Japan Science and Technology Corporation, Osaka. imamura@obi.or.jp
Takahashi M
Okada H
Tsukada H
Shiomitsu T
Onoe H
Watanabe Y
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Źródło :
Neuroscience research [Neurosci Res] 1997 Aug; Vol. 28 (4), pp. 299-309.
Typ publikacji :
Journal Article
MeSH Terms :
Neurons/*physiology
Spectroscopy, Near-Infrared/*methods
Visual Cortex/*physiology
Animals ; Cats ; Hemoglobins/metabolism ; Male ; Osmolar Concentration ; Oxygen ; Oxyhemoglobins/metabolism ; Photic Stimulation ; Rats ; Rats, Wistar ; Respiration ; Visual Cortex/cytology
Czasopismo naukowe
Tytuł :
Differential specificities of single mitral cells in rabbit olfactory bulb for a homologous series of fatty acid odor molecules.
Autorzy :
Mori K; Department of Neuroscience, Osaka Bioscience Institute, Japan.
Mataga N
Imamura K
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Źródło :
Journal of neurophysiology [J Neurophysiol] 1992 Mar; Vol. 67 (3), pp. 786-9.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Fatty Acids/*pharmacology
Neurons/*physiology
Odorants/*analysis
Olfactory Bulb/*physiology
Animals ; Carboxylic Acids/pharmacology ; Neurons/drug effects ; Olfactory Bulb/cytology ; Rabbits ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Localization of prostaglandin endoperoxide synthase in neurons and glia in monkey brain.
Autorzy :
Tsubokura S; Department of Neuroscience, Osaka Bioscience Institute, Japan.
Watanabe Y
Ehara H
Imamura K
Sugimoto O
Kagamiyama H
Yamamoto S
Hayaishi O
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Źródło :
Brain research [Brain Res] 1991 Mar 08; Vol. 543 (1), pp. 15-24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain/*enzymology
Neuroglia/*enzymology
Neurons/*enzymology
Prostaglandin-Endoperoxide Synthases/*analysis
Animals ; Antibodies, Monoclonal ; Brain/cytology ; Cerebellum/enzymology ; Electrophoresis, Polyacrylamide Gel ; Hippocampus/enzymology ; Immunoenzyme Techniques ; Macaca ; Male ; Neuroglia/cytology ; Neurons/cytology ; Organ Specificity ; Temporal Lobe/enzymology
Czasopismo naukowe
Tytuł :
[Antineuronal antibody in carcinomatous neuropathy].
Autorzy :
Imamura K
Yasuda T
Sugimura K
Takahashi A
Yamada Y
Pokaż więcej
Źródło :
Rinsho shinkeigaku = Clinical neurology [Rinsho Shinkeigaku] 1989 Nov; Vol. 29 (11), pp. 1331-7.
Typ publikacji :
Case Reports; English Abstract; Journal Article
MeSH Terms :
Sensation*
Autoantibodies/*analysis
Carcinoma, Small Cell/*complications
Lung Neoplasms/*complications
Neurons/*immunology
Aged ; Female ; Humans ; Nervous System Diseases/immunology ; Purkinje Cells/immunology
Czasopismo naukowe

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