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Tytuł:
Identification of imidazo[4,5-c]pyridin-2-one derivatives as novel Src family kinase inhibitors against glioblastoma.
Autorzy:
Zhang L; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, PR China.
Yang Z; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, PR China.
Sang H; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, PR China.
Jiang Y; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, PR China.
Zhou M; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, PR China.
Huang C; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, PR China.
Huang C; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, PR China.
Wu X; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, PR China.
Zhang T; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, PR China.; Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Guangzhou, PR China.
Zhang X; Department of Neurobiology, Guangdong Province Key Laboratory of Psychiatric Disorders, School of Basic Medical Sciences, Southern Medical University, Guangzhou, PR China.
Wan S; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, PR China.
Zhang J; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, PR China.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 1541-1552.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents/*pharmacology
Brain Neoplasms/*drug therapy
Glioblastoma/*drug therapy
Imidazoles/*pharmacology
Protein Kinase Inhibitors/*pharmacology
Quinolones/*pharmacology
src-Family Kinases/*antagonists & inhibitors
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Glioblastoma/metabolism ; Glioblastoma/pathology ; Humans ; Imidazoles/chemical synthesis ; Imidazoles/chemistry ; Models, Molecular ; Molecular Structure ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Quinolones/chemical synthesis ; Quinolones/chemistry ; Structure-Activity Relationship ; src-Family Kinases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Steroid-Functionalized Imidazolium Salts with an Extended Spectrum of Antifungal and Antibacterial Activity.
Autorzy:
Malinowska M; Department of Organic Chemistry, Faculty of Chemistry, University of Bialystok, Ciołkowskiego, 1K, 15-245 Białystok, Poland.
Sawicka D; Department of Experimental Pharmacology, Faculty of Health Sciences, Medical University of Bialystok, Szpitalna, 37, 15-295 Białystok, Poland.
Niemirowicz-Laskowska K; Department of Experimental Pharmacology, Faculty of Health Sciences, Medical University of Bialystok, Szpitalna, 37, 15-295 Białystok, Poland.
Wielgat P; Department of Clinical Pharmacology, Faculty of Medicine with the Division of Dentistry and Division of Medical Education in English, Medical University of Bialystok, Waszyngtona, 15A, 15-274 Białystok, Poland.
Car H; Department of Experimental Pharmacology, Faculty of Health Sciences, Medical University of Bialystok, Szpitalna, 37, 15-295 Białystok, Poland.
Hauschild T; Department of Microbiology and Biotechnology, Faculty of Biology, University of Bialystok, Ciołkowskiego, 1J, 15-245 Białystok, Poland.
Hryniewicka A; Department of Organic Chemistry, Faculty of Chemistry, University of Bialystok, Ciołkowskiego, 1K, 15-245 Białystok, Poland.; Department of Organic Chemistry, Faculty of Pharmacy with the Division of Laboratory Medicine, Medical University of Bialystok, Mickiewicza, 2A, 15-222 Bialystok, Poland.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Nov 10; Vol. 22 (22). Date of Electronic Publication: 2021 Nov 10.
Typ publikacji:
Journal Article
MeSH Terms:
Anti-Bacterial Agents/*pharmacology
Antifungal Agents/*pharmacology
Imidazoles/*pharmacology
Steroids/*pharmacology
Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/chemistry ; Antifungal Agents/chemical synthesis ; Antifungal Agents/chemistry ; Bacteria/drug effects ; Cell Line ; Cell Survival/drug effects ; Fungi/drug effects ; Hemolysis/drug effects ; Humans ; Imidazoles/chemical synthesis ; Imidazoles/chemistry ; Mycoses/drug therapy ; Salts/chemical synthesis ; Salts/chemistry ; Salts/pharmacology ; Steroids/chemical synthesis ; Steroids/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Phase I study in healthy participants to evaluate safety, tolerability, and pharmacokinetics of inhaled nezulcitinib, a potential treatment for COVID-19.
Autorzy:
Pfeifer ND; Theravance Biopharma US, Inc., South San Francisco, California, USA.
Lo A; Theravance Biopharma US, Inc., South San Francisco, California, USA.
Bourdet DL; Theravance Biopharma US, Inc., South San Francisco, California, USA.
Colley K; Theravance Biopharma US, Inc., South San Francisco, California, USA.
Singh D; Medicines Evaluation Unit, University of Manchester, Manchester University, Manchester, UK.
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Źródło:
Clinical and translational science [Clin Transl Sci] 2021 Nov; Vol. 14 (6), pp. 2556-2565. Date of Electronic Publication: 2021 Aug 31.
Typ publikacji:
Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:
COVID-19 Drug Treatment*
Azetidines/*adverse effects
Imidazoles/*adverse effects
Indazoles/*adverse effects
Piperidines/*adverse effects
Administration, Inhalation ; Adult ; Area Under Curve ; Azetidines/administration & dosage ; Azetidines/pharmacokinetics ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Female ; Healthy Volunteers ; Humans ; Imidazoles/administration & dosage ; Imidazoles/pharmacokinetics ; Indazoles/administration & dosage ; Indazoles/pharmacokinetics ; Killer Cells, Natural/drug effects ; Killer Cells, Natural/immunology ; Lymphocyte Count ; Male ; Middle Aged ; Piperidines/administration & dosage ; Piperidines/pharmacokinetics ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Protein Modification with Ribose Generates N -(5-hydro-5-methyl-4-imidazolone-2-yl)-ornithine.
Autorzy:
Ban I; Laboratory of Food and Regulation Biology, Department of Bioscience, Graduate School of Agriculture, Tokai University 9-1-1, Higashi-ku, Kumamoto 862-8652, Japan.
Sugawa H; Laboratory of Food and Regulation Biology, Department of Bioscience, Graduate School of Agriculture, Tokai University 9-1-1, Higashi-ku, Kumamoto 862-8652, Japan.
Nagai R; Laboratory of Food and Regulation Biology, Department of Bioscience, Graduate School of Agriculture, Tokai University 9-1-1, Higashi-ku, Kumamoto 862-8652, Japan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Jan 22; Vol. 23 (3). Date of Electronic Publication: 2022 Jan 22.
Typ publikacji:
Journal Article
MeSH Terms:
Protein Processing, Post-Translational*
Imidazoles/*chemistry
Ornithine/*analogs & derivatives
Ribose/*chemistry
Serum Albumin, Bovine/*chemistry
Serum Albumin, Bovine/*metabolism
Animals ; Cattle ; Gelatin/chemistry ; Glycosylation ; Imidazoles/metabolism ; Ornithine/chemistry ; Ornithine/metabolism ; Oxidation-Reduction ; Pyruvaldehyde/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Retrospective analysis of arterial occlusive events in the PACE trial by an independent adjudication committee.
Autorzy:
Januzzi JL; Massachusetts General Hospital, 55 Fruit Street, Boston, MA, USA. .
Garasic JM; Massachusetts General Hospital, 55 Fruit Street, Boston, MA, USA.
Kasner SE; University of Pennsylvania, Philadelphia, PA, USA.
McDonald V; Barts Health NHS Trust, London, England.
Petrie MC; University of Glasgow, Glasgow, Scotland.
Seltzer J; ACI Clinical, Bala Cynwyd, PA, USA.
Mauro M; Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Croce K; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Berman E; Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Deininger M; Huntsman Cancer Institute, The University of Utah, Salt Lake City, UT, USA.
Hochhaus A; Universitätsklinikum Jena, Jena, Germany.
Pinilla-Ibarz J; H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.
Nicolini F; Centre Hospitalier Lyon-Sud, Pierre-Bénite, Lyon, France.
Kim DW; Catholic Hematology Hospital, Seoul St. Mary's Hospital, Leukemia Research Institute, The Catholic University of Korea, Seoul, South Korea.
DeAngelo DJ; Dana-Farber Cancer Institute, Boston, MA, USA.
Kantarjian H; The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Xu J; Millennium Pharmaceuticals, Inc., A Wholly Owned Subsidiary of Takeda Pharmaceutical Company Limited, Cambridge, MA, USA.
Hall T; Millennium Pharmaceuticals, Inc., A Wholly Owned Subsidiary of Takeda Pharmaceutical Company Limited, Cambridge, MA, USA.
Srivastava S; Millennium Pharmaceuticals, Inc., A Wholly Owned Subsidiary of Takeda Pharmaceutical Company Limited, Cambridge, MA, USA.
Naranjo D; Millennium Pharmaceuticals, Inc., A Wholly Owned Subsidiary of Takeda Pharmaceutical Company Limited, Cambridge, MA, USA.
Cortes J; Georgia Cancer Center, Augusta, GA, USA.
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Źródło:
Journal of hematology & oncology [J Hematol Oncol] 2022 Jan 06; Vol. 15 (1), pp. 1. Date of Electronic Publication: 2022 Jan 06.
Typ publikacji:
Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Agents/*adverse effects
Arterial Occlusive Diseases/*chemically induced
Imidazoles/*adverse effects
Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*drug therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma/*drug therapy
Protein Kinase Inhibitors/*adverse effects
Pyridazines/*adverse effects
Adult ; Aged ; Aged, 80 and over ; Antineoplastic Agents/therapeutic use ; Female ; Humans ; Imidazoles/therapeutic use ; Incidence ; Male ; Middle Aged ; Protein Kinase Inhibitors/therapeutic use ; Pyridazines/therapeutic use ; Retrospective Studies ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Assessment of drug-drug interactions between moxonidine and antiepileptic drugs in the maximal electroshock seizure test in mice.
Autorzy:
Łukawski K; Department of Physiopathology, Institute of Rural Health, Lublin, Poland.; Department of Pathophysiology, Medical University of Lublin, Lublin, Poland.
Czuczwar SJ; Department of Pathophysiology, Medical University of Lublin, Lublin, Poland.
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Źródło:
Basic & clinical pharmacology & toxicology [Basic Clin Pharmacol Toxicol] 2022 Jan; Vol. 130 (1), pp. 28-34. Date of Electronic Publication: 2021 Oct 24.
Typ publikacji:
Journal Article
MeSH Terms:
Anticonvulsants/*pharmacology
Antihypertensive Agents/*pharmacology
Imidazoles/*pharmacology
Seizures/*drug therapy
Animals ; Anticonvulsants/pharmacokinetics ; Antihypertensive Agents/administration & dosage ; Avoidance Learning/drug effects ; Brain/metabolism ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Drug Interactions ; Electroshock ; Imidazoles/administration & dosage ; Male ; Mice ; Tissue Distribution
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Molecular Modeling Unveils the Effective Interaction of B-RAF Inhibitors with Rare B-RAF Insertion Variants.
Autorzy:
Scaini MC; Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.
Piccin L; Melanoma Unit, Oncology 2 Unit, Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.
Bassani D; Molecular Modeling Section (MMS), Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padua, Italy.
Scapinello A; Anatomy and Pathological Histology Unit, Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.
Pellegrini S; Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.
Poggiana C; Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.
Catoni C; Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.
Tonello D; Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.
Pigozzo J; Melanoma Unit, Oncology 2 Unit, Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.
Dall'Olmo L; Soft-Tissue, Peritoneum and Melanoma Surgical Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.; Department of Surgery, Oncology and Gastroenterology (DISCOG), University of Padua, 35128 Padua, Italy.
Rosato A; Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.; Department of Surgery, Oncology and Gastroenterology (DISCOG), University of Padua, 35128 Padua, Italy.
Moro S; Molecular Modeling Section (MMS), Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padua, Italy.
Chiarion-Sileni V; Melanoma Unit, Oncology 2 Unit, Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.
Menin C; Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jul 31; Vol. 24 (15). Date of Electronic Publication: 2023 Jul 31.
Typ publikacji:
Journal Article
MeSH Terms:
Melanoma*/drug therapy
Melanoma*/genetics
Melanoma*/pathology
Skin Neoplasms*/pathology
Male ; Humans ; Proto-Oncogene Proteins B-raf/genetics ; Imidazoles/pharmacology ; Imidazoles/therapeutic use ; Oximes/pharmacology ; Oximes/therapeutic use ; Mutation ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Pyridones/therapeutic use ; Pyrimidinones/therapeutic use
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Different Structures-Similar Effect: Do Substituted 5-(4-Methoxyphenyl)-1 H -indoles and 5-(4-Methoxyphenyl)-1 H -imidazoles Represent a Common Pharmacophore for Substrate Selective Inhibition of Linoleate Oxygenase Activity of ALOX15?
Autorzy:
Zhuravlev A; Lomonosov Institute of Fine Chemical Technologies, MIREA-Russian Technological University, Vernadskogo pr. 86, 119571 Moscow, Russia.
Cruz A; Departament de Química, Universitat Autònoma de Barcelona, Bellaterra, 08193 Barcelona, Spain.
Aksenov V; Lomonosov Institute of Fine Chemical Technologies, MIREA-Russian Technological University, Vernadskogo pr. 86, 119571 Moscow, Russia.; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklihio-Maklaja Str., 16/10c4, 117997 Moscow, Russia.
Golovanov A; Lomonosov Institute of Fine Chemical Technologies, MIREA-Russian Technological University, Vernadskogo pr. 86, 119571 Moscow, Russia.
Lluch JM; Departament de Química, Universitat Autònoma de Barcelona, Bellaterra, 08193 Barcelona, Spain.; Institut de Biotecnologia i de Biomedicina (IBB), Universitat Autònoma de Barcelona, Bellaterra, 08193 Barcelona, Spain.
Kuhn H; Department of Biochemistry, Charite-University Medicine Berlin, Corporate Member of Free University Berlin and Humboldt University Berlin, Charitéplatz 1, D-10117 Berlin, Germany.
González-Lafont À; Departament de Química, Universitat Autònoma de Barcelona, Bellaterra, 08193 Barcelona, Spain.; Institut de Biotecnologia i de Biomedicina (IBB), Universitat Autònoma de Barcelona, Bellaterra, 08193 Barcelona, Spain.
Ivanov I; Lomonosov Institute of Fine Chemical Technologies, MIREA-Russian Technological University, Vernadskogo pr. 86, 119571 Moscow, Russia.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Jul 14; Vol. 28 (14). Date of Electronic Publication: 2023 Jul 14.
Typ publikacji:
Journal Article
MeSH Terms:
Linoleic Acid*/metabolism
Pharmacophore*
Animals ; Rabbits ; Mammals/metabolism ; Linoleic Acids/metabolism ; Arachidonate 15-Lipoxygenase/chemistry ; Imidazoles/pharmacology ; Imidazoles/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A New Oxadiazole-Based Topsentin Derivative Modulates Cyclin-Dependent Kinase 1 Expression and Exerts Cytotoxic Effects on Pancreatic Cancer Cells.
Autorzy:
Pecoraro C; Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), Università degli Studi di Palermo, Via Archirafi 32, 90123 Palermo, Italy.; Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC, VU University Medical Center (VUmc), De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.
Parrino B; Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), Università degli Studi di Palermo, Via Archirafi 32, 90123 Palermo, Italy.
Cascioferro S; Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), Università degli Studi di Palermo, Via Archirafi 32, 90123 Palermo, Italy.
Puerta A; Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC, VU University Medical Center (VUmc), De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.; BioLab, Instituto Universitario de Bio-Orgánica 'Antonio González' (IUBO-AG), Universidad de La Laguna, c/Astrofísico Francisco Sánchez 2, 38206 La Laguna, Spain.
Avan A; Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC, VU University Medical Center (VUmc), De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.; Metabolic Syndrome Research Center, Mashhad University of Medical Science, Mashhad 91886-17871, Iran.
Peters GJ; Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC, VU University Medical Center (VUmc), De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.; Department of Biochemistry, Medical University of Gdansk, 80-210 Gdansk, Poland.
Diana P; Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), Università degli Studi di Palermo, Via Archirafi 32, 90123 Palermo, Italy.
Giovannetti E; Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC, VU University Medical Center (VUmc), De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.; Cancer Pharmacology Laboratory, Fondazione Pisana per la Scienza, Via Ferruccio Giovannini 13, San Giuliano Terme, 56017 Pisa, Italy.
Carbone D; Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), Università degli Studi di Palermo, Via Archirafi 32, 90123 Palermo, Italy.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2021 Dec 21; Vol. 27 (1). Date of Electronic Publication: 2021 Dec 21.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents/*chemistry
CDC2 Protein Kinase/*antagonists & inhibitors
Carcinoma, Pancreatic Ductal/*drug therapy
Imidazoles/*chemistry
Indoles/*chemistry
Oxadiazoles/*chemistry
Pancreatic Neoplasms/*drug therapy
Protein Kinase Inhibitors/*chemistry
Antineoplastic Agents/pharmacology ; Apoptosis ; CDC2 Protein Kinase/genetics ; Carcinoma, Pancreatic Ductal/metabolism ; Catalytic Domain ; Cell Line, Tumor ; Cell Proliferation ; Drug Screening Assays, Antitumor ; Humans ; Imidazoles/pharmacology ; Indoles/pharmacology ; Molecular Docking Simulation ; Pancreatic Neoplasms/metabolism ; Protein Binding ; Protein Kinase Inhibitors/pharmacology ; Signal Transduction ; Structure-Activity Relationship
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Angiotensin Type 2 and Mas Receptor Activation Prevents Myocardial Fibrosis and Hypertrophy through the Reduction of Inflammatory Cell Infiltration and Local Sympathetic Activity in Angiotensin II-Dependent Hypertension.
Autorzy:
Castoldi G; Dipartimento di Medicina e Chirurgia, Università degli Studi di Milano-Bicocca, 20900 Monza, Italy.
Carletti R; Dipartimento di Medicina Traslazionale e di Precisione, Sapienza Universita' di Roma, 00161 Rome, Italy.
Ippolito S; Laboratorio Analisi Chimico Cliniche, Ospedale San Gerardo, ASST Monza, 20900 Monza, Italy.
Stella A; Dipartimento di Medicina e Chirurgia, Università degli Studi di Milano-Bicocca, 20900 Monza, Italy.
Zerbini G; Unita Complicanze del Diabete, IRCCS Istituto Scientifico San Raffaele, 20132 Milan, Italy.
Pelucchi S; Dipartimento di Medicina e Chirurgia, Università degli Studi di Milano-Bicocca, 20900 Monza, Italy.
Zatti G; Dipartimento di Medicina e Chirurgia, Università degli Studi di Milano-Bicocca, 20900 Monza, Italy.; Clinica Ortopedica, Ospedale San Gerardo, ASST Monza, 20900 Monza, Italy.
di Gioia CRT; Dipartimento di Scienze Radiologiche, Oncologiche e Anatomopatologiche, Istituto di Anatomia Patologica, Sapienza Universita' di Roma, 00161 Rome, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Dec 20; Vol. 22 (24). Date of Electronic Publication: 2021 Dec 20.
Typ publikacji:
Comparative Study; Journal Article
MeSH Terms:
Angiotensin I/*administration & dosage
Angiotensin II/*administration & dosage
Cardiomegaly/*prevention & control
Hypertension/*drug therapy
Imidazoles/*administration & dosage
Losartan/*administration & dosage
Peptide Fragments/*administration & dosage
Sulfonamides/*administration & dosage
Thiophenes/*administration & dosage
Angiotensin I/pharmacology ; Angiotensin II/pharmacology ; Animals ; Cardiomegaly/metabolism ; Disease Models, Animal ; Fibrosis ; Hypertension/chemically induced ; Hypertension/metabolism ; Imidazoles/pharmacology ; Injections, Intraperitoneal ; Losartan/pharmacology ; Male ; Peptide Fragments/pharmacology ; Proto-Oncogene Mas/metabolism ; Rats ; Rats, Sprague-Dawley ; Sulfonamides/pharmacology ; Thiophenes/pharmacology ; Tyrosine 3-Monooxygenase/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Imidazole-Thiosemicarbazide Derivatives as Potent Anti- Mycobacterium tuberculosis Compounds with Antibiofilm Activity.
Autorzy:
Bekier A; Department of Molecular Microbiology, Faculty of Biology and Environmental Protection, University of Lodz, 90-237 Lodz, Poland.
Kawka M; Department of Molecular Microbiology, Faculty of Biology and Environmental Protection, University of Lodz, 90-237 Lodz, Poland.
Lach J; Department of Molecular Microbiology, Faculty of Biology and Environmental Protection, University of Lodz, 90-237 Lodz, Poland.; Biobank Lab, Department of Molecular Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, 90-237 Lodz, Poland.
Dziadek J; Laboratory of Genetics and Physiology of Mycobacterium, Institute of Medical Biology, Polish Academy of Sciences, 93-232 Lodz, Poland.
Paneth A; Department of Organic Chemistry, Faculty of Pharmacy, Medical University of Lublin, 20-093 Lublin, Poland.
Gatkowska J; Department of Molecular Microbiology, Faculty of Biology and Environmental Protection, University of Lodz, 90-237 Lodz, Poland.
Dzitko K; Department of Molecular Microbiology, Faculty of Biology and Environmental Protection, University of Lodz, 90-237 Lodz, Poland.
Dziadek B; Department of Molecular Microbiology, Faculty of Biology and Environmental Protection, University of Lodz, 90-237 Lodz, Poland.
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Źródło:
Cells [Cells] 2021 Dec 09; Vol. 10 (12). Date of Electronic Publication: 2021 Dec 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Imidazoles/*pharmacology
Mycobacterium tuberculosis/*drug effects
Semicarbazides/*pharmacology
Tuberculosis/*drug therapy
Antitubercular Agents ; Biofilms/drug effects ; Cell Line ; Humans ; Imidazoles/chemistry ; Macrophages/drug effects ; Macrophages/microbiology ; Microbial Sensitivity Tests ; Mycobacterium tuberculosis/pathogenicity ; Tuberculosis/microbiology ; Tuberculosis/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Utilization of PEGylated cerosomes for effective topical delivery of fenticonazole nitrate: in-vitro characterization, statistical optimization, and in-vivo assessment.
Autorzy:
Albash R; Department of Pharmaceutics, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology, Giza, Egypt.
Yousry C; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Al-Mahallawi AM; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt.; Department of Pharmaceutics, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), Giza, Egypt.
Alaa-Eldin AA; Department of Pharmaceutics, Faculty of Pharmacy, Fayoum University, Elfayoum, Egypt.
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Źródło:
Drug delivery [Drug Deliv] 2021 Dec; Vol. 28 (1), pp. 1-9.
Typ publikacji:
Journal Article
MeSH Terms:
Antifungal Agents/*administration & dosage
Ceramides/*chemistry
Drug Carriers/*chemistry
Imidazoles/*administration & dosage
Polyethylene Glycols/*chemistry
Administration, Cutaneous ; Animals ; Antifungal Agents/pharmacokinetics ; Area Under Curve ; Chemistry, Pharmaceutical ; Dermatologic Agents/administration & dosage ; Dermatologic Agents/pharmacokinetics ; Dose-Response Relationship, Drug ; Drug Stability ; Imidazoles/pharmacokinetics ; Male ; Metabolic Clearance Rate ; Microscopy, Electron, Transmission ; Particle Size ; Rats, Wistar ; Skin Absorption/drug effects ; Surface Properties ; Surface-Active Agents ; Rats
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Epigenetic modulation and apoptotic induction by a novel imidazo-benzamide derivative in human lung adenocarcinoma cells.
Autorzy:
Arjunan A; Department of Biochemistry and Molecular Biology, School of Life Sciences, Pondicherry University, Puducherry, Puducherry, 605 014, India.
Pajaniradje S; Centre for Nanoscience and Technology, Anna University, Chennai, Tamil Nadu, 600025, India.
Francis AP; Department of Biochemistry and Molecular Biology, School of Life Sciences, Pondicherry University, Puducherry, Puducherry, 605 014, India.
Subramanian S; Department of Biochemistry and Molecular Biology, School of Life Sciences, Pondicherry University, Puducherry, Puducherry, 605 014, India.
Chandramohan S; Department of Biochemistry and Molecular Biology, School of Life Sciences, Pondicherry University, Puducherry, Puducherry, 605 014, India.
Parthasarathi D; Postgraduate and Research Department of Chemistry, Jamal Mohamed College, Bharathidasan University, Tiruchirappalli, Tamil Nadu, 620 020, India.
Sajith AM; Postgraduate and Research Department of Chemistry, Kasaragod Government College, Kannur University, Kasaragod, Kerala, 671123, India.
Padusha MSA; Postgraduate and Research Department of Chemistry, Jamal Mohamed College, Bharathidasan University, Tiruchirappalli, Tamil Nadu, 620 020, India.
Mathur PP; Department of Biochemistry and Molecular Biology, School of Life Sciences, Pondicherry University, Puducherry, Puducherry, 605 014, India.
Rajagopalan R; Department of Biochemistry and Molecular Biology, School of Life Sciences, Pondicherry University, Puducherry, Puducherry, 605 014, India. .
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Źródło:
Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences [Daru] 2021 Dec; Vol. 29 (2), pp. 377-387. Date of Electronic Publication: 2021 Oct 12.
Typ publikacji:
Journal Article
MeSH Terms:
Adenocarcinoma of Lung/*genetics
Benzamides/*pharmacology
DNA (Cytosine-5-)-Methyltransferase 1/*metabolism
Imidazoles/*pharmacology
Lung Neoplasms/*genetics
A549 Cells ; Adenocarcinoma of Lung/drug therapy ; Adenocarcinoma of Lung/metabolism ; Benzamides/chemistry ; CCAAT-Enhancer-Binding Proteins/metabolism ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; DNA (Cytosine-5-)-Methyltransferase 1/chemistry ; Epigenesis, Genetic/drug effects ; Gene Expression Regulation, Neoplastic/drug effects ; Histone Deacetylase 1/metabolism ; Humans ; Imidazoles/chemistry ; Lung Neoplasms/drug therapy ; Lung Neoplasms/metabolism ; Models, Molecular ; Molecular Docking Simulation ; Protein Conformation ; Ubiquitin-Protein Ligases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Study on the Effectiveness of Simultaneous Recovery and Concentration of 1-Ethyl-3-methylimidazolium Chloride Ionic Liquid by Electrodialysis with Heterogeneous Ion-Exchange Membranes.
Autorzy:
Babilas D; Department of Inorganic, Analytical Chemistry and Electrochemistry, Faculty of Chemistry, Silesian University of Technology, B. Krzywoustego 6, 44-100 Gliwice, Poland.
Kowalik-Klimczak A; Bioeconomy and Eco-Innovation Centre, Łukasiewicz Research Network-The Institute for Sustainable Technologies, Pułaskiego 6/10, 26-600 Radom, Poland.
Dydo P; Department of Inorganic, Analytical Chemistry and Electrochemistry, Faculty of Chemistry, Silesian University of Technology, B. Krzywoustego 6, 44-100 Gliwice, Poland.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Dec 01; Vol. 22 (23). Date of Electronic Publication: 2021 Dec 01.
Typ publikacji:
Journal Article
MeSH Terms:
Dialysis/*methods
Imidazoles/*chemistry
Ionic Liquids/*chemistry
Imidazoles/isolation & purification ; Ion Exchange ; Ionic Liquids/isolation & purification ; Wastewater/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Achieving Enhanced Photochromic Properties of Diarylethene through Host-Guest Interaction in Aqueous Solution.
Autorzy:
Sun D; The State Key Laboratory of Refractories and Metallurgy, School of Chemistry and Chemical Engineering, Wuhan University of Science and Technology, Wuhan, 430081, P. R. China.
Wu Y; The State Key Laboratory of Refractories and Metallurgy, School of Chemistry and Chemical Engineering, Wuhan University of Science and Technology, Wuhan, 430081, P. R. China.
Han X; The State Key Laboratory of Refractories and Metallurgy, School of Chemistry and Chemical Engineering, Wuhan University of Science and Technology, Wuhan, 430081, P. R. China.; Institute of Advanced Materials and Nanotechnology, Wuhan University of Science and Technology, Wuhan, 430081, P. R. China.
Liu S; The State Key Laboratory of Refractories and Metallurgy, School of Chemistry and Chemical Engineering, Wuhan University of Science and Technology, Wuhan, 430081, P. R. China.; Institute of Advanced Materials and Nanotechnology, Wuhan University of Science and Technology, Wuhan, 430081, P. R. China.
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Źródło:
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2021 Nov 22; Vol. 27 (65), pp. 16153-16160. Date of Electronic Publication: 2021 Oct 13.
Typ publikacji:
Journal Article
MeSH Terms:
Bridged-Ring Compounds*
Imidazoles*
Fluorescence ; Fluorescent Dyes ; Water
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Pharmacokinetics of daridorexant, a dual orexin receptor antagonist, are not affected by renal impairment.
Autorzy:
Berger B; Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland.
Muehlan C; Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland.
Klein G; APEX GmbH, Munich, Germany.
Dingemanse J; Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland.
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Źródło:
Clinical and translational science [Clin Transl Sci] 2021 Nov; Vol. 14 (6), pp. 2132-2138. Date of Electronic Publication: 2021 Jun 21.
Typ publikacji:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Renal Insufficiency*
Imidazoles/*pharmacokinetics
Orexin Receptor Antagonists/*pharmacokinetics
Pyrrolidines/*pharmacokinetics
Aged ; Aged, 80 and over ; Female ; Humans ; Imidazoles/administration & dosage ; Male ; Middle Aged ; Orexin Receptor Antagonists/administration & dosage ; Pyrrolidines/administration & dosage
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Experimental determination of the partitioning of representative organic pollutants to the air–water interface.
Autorzy:
McLay, Emma M. (AUTHOR)
Abdel Nour, Carole (AUTHOR)
Huang, Yao Yan (AUTHOR)
Golay, Zoë M. (AUTHOR)
Wong-Wah-Chung, Pascal (AUTHOR)
Rossignol, Stéphanie (AUTHOR)
Donaldson, D. James (AUTHOR)
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Temat:
*Pollutants
Air-water interfaces
Linear free energy relationship
Langmuir isotherms
Laser-induced fluorescence
Imidazoles
Źródło:
Environmental Science: Processes & Impacts. Mar2024, Vol. 26 Issue 3, p510-518. 9p.
Czasopismo naukowe
Szczegóły
Tytuł:
Design, synthesis, in vitro, and in silico evaluations of benzo[d]imidazole-amide-1,2,3-triazole-N-arylacetamide hybrids as new antidiabetic agents targeting α-glucosidase.
Autorzy:
Yousefnejad, Faeze (AUTHOR)
Mohammadi-Moghadam-Goozali, Mahyar (AUTHOR)
Sayahi, Mohammad Hosein (AUTHOR)
Halimi, Mohammad (AUTHOR)
Moazzam, Ali (AUTHOR)
Mohammadi-Khanaposhtani, Maryam (AUTHOR)
Mojtabavi, Somayeh (AUTHOR)
Asadi, Mehdi (AUTHOR)
Faramarzi, Mohammad Ali (AUTHOR)
Larijani, Bagher (AUTHOR)
Amanlou, Massoud (AUTHOR)
Mahdavi, Mohammad (AUTHOR)
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Źródło:
Scientific Reports. 7/31/2023, Vol. 13 Issue 1, p1-14. 14p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Eco-Friendly Synthesis of 1 H -benzo[ d ]imidazole Derivatives by ZnO NPs Characterization, DFT Studies, Antioxidant and Insilico Studies.
Autorzy:
Mohammed, Samar M. (AUTHOR)
Shehab, Wesam S. (AUTHOR)
Emwas, Abdul-Hamid M. (AUTHOR)
Jaremko, Mariusz (AUTHOR)
Abdellattif, Magda H. (AUTHOR)
Zordok, Wael A. (AUTHOR)
Tantawy, Eman S. (AUTHOR)
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Źródło:
Pharmaceuticals (14248247). Jul2023, Vol. 16 Issue 7, p969. 23p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 61-80 z 31045

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