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Tytuł :
Sp3 Transcription Factor Cooperates with the Kaposi's Sarcoma-Associated Herpesvirus ORF50 Protein To Synergistically Activate Specific Viral and Cellular Gene Promoters.
Autorzy :
Chen LY; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang-Gung University, Taoyuan, Taiwan.
Chen LW; Department of Respiratory Care, Chang-Gung University of Science and Technology, Chiayi, Taiwan.; Department of Pediatric Surgery, Chang-Gung Memorial Hospital, Chiayi, Taiwan.
Peng KT; Department of Orthopedic Surgery, Chang-Gung Memorial Hospital, Chiayi, Taiwan.
Hung CH; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang-Gung University, Taoyuan, Taiwan.
Chang PJ; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang-Gung University, Taoyuan, Taiwan .; Department of Nephrology, Chang-Gung Memorial Hospital, Chiayi, Taiwan.
Wang SS; Department of Pediatric Surgery, Chang-Gung Memorial Hospital, Chiayi, Taiwan .; School of Medicine, Chang-Gung University, Taoyuan, Taiwan.
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Źródło :
Journal of virology [J Virol] 2020 Aug 31; Vol. 94 (18). Date of Electronic Publication: 2020 Aug 31 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Promoter Regions, Genetic*
Transcription, Genetic*
Herpesvirus 8, Human/*genetics
Immediate-Early Proteins/*genetics
Sp1 Transcription Factor/*genetics
Sp3 Transcription Factor/*genetics
Trans-Activators/*genetics
Animals ; Binding Sites ; Cell Line ; Cell Line, Tumor ; Clone Cells ; Fibroblasts/virology ; Gene Expression Regulation ; HEK293 Cells ; Herpesvirus 8, Human/metabolism ; Host-Pathogen Interactions/genetics ; Humans ; Immediate-Early Proteins/metabolism ; Immunoglobulin J Recombination Signal Sequence-Binding Protein/genetics ; Immunoglobulin J Recombination Signal Sequence-Binding Protein/metabolism ; Interleukin-10/genetics ; Interleukin-10/metabolism ; Lymphocytes/virology ; Mice ; Protein Binding ; Response Elements ; Signal Transduction ; Sp1 Transcription Factor/metabolism ; Sp3 Transcription Factor/metabolism ; Trans-Activators/metabolism ; Viral Proteins/genetics ; Viral Proteins/metabolism ; Viral Regulatory and Accessory Proteins/genetics ; Viral Regulatory and Accessory Proteins/metabolism
Czasopismo naukowe
Tytuł :
TCRP1 induces tamoxifen resistance by promoting the activation of SGK1 in MCF‑7 cells.
Autorzy :
Zhao S; Department of Breast and Thyroid Surgery, Wuzhong People's Hospital of Suzhou City, Suzhou, Jiangsu 215128, P.R. China.
Li X; Department of Breast and Thyroid Surgery, Wuzhong People's Hospital of Suzhou City, Suzhou, Jiangsu 215128, P.R. China.
Yin L; Department of Breast and Thyroid Surgery, Wuzhong People's Hospital of Suzhou City, Suzhou, Jiangsu 215128, P.R. China.
Hou L; Department of Breast and Thyroid Surgery, Wuzhong People's Hospital of Suzhou City, Suzhou, Jiangsu 215128, P.R. China.
Lan J; Department of General Surgery, The First Hospital Affiliated of Suzhou University, Suzhou, Jiangsu 215006, P.R. China.
Zhu X; Department of Breast and Thyroid Surgery, The Second Affiliated Hospital of Suzhou University, Suzhou, Jiangsu 215004, P.R. China.
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Źródło :
Oncology reports [Oncol Rep] 2020 Jun; Vol. 43 (6), pp. 2017-2027. Date of Electronic Publication: 2020 Apr 03.
Typ publikacji :
Journal Article
MeSH Terms :
Breast Neoplasms/*drug therapy
Breast Neoplasms/*metabolism
Immediate-Early Proteins/*metabolism
Protein-Serine-Threonine Kinases/*metabolism
Proteins/*metabolism
Tamoxifen/*pharmacology
Animals ; Antineoplastic Agents, Hormonal/pharmacology ; Apoptosis/drug effects ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Cell Proliferation/drug effects ; Drug Resistance, Neoplasm ; Female ; Humans ; Immediate-Early Proteins/genetics ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Protein-Serine-Threonine Kinases/genetics ; Proteins/genetics ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Effect of SUMO-SIM Interaction on the ICP0-Mediated Degradation of PML Isoform II and Its Associated Proteins in Herpes Simplex Virus 1 Infection.
Autorzy :
Jan Fada B; Department of Biological Sciences, Wayne State University, Detroit, Michigan, USA.
Kaadi E; Department of Biological Sciences, Wayne State University, Detroit, Michigan, USA.
Samrat SK; Department of Biological Sciences, Wayne State University, Detroit, Michigan, USA.
Zheng Y; Department of Biological Sciences, Wayne State University, Detroit, Michigan, USA.
Gu H; Department of Biological Sciences, Wayne State University, Detroit, Michigan, USA .
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Źródło :
Journal of virology [J Virol] 2020 Jun 01; Vol. 94 (12). Date of Electronic Publication: 2020 Jun 01 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Processing, Post-Translational*
Herpesvirus 1, Human/*immunology
Host-Pathogen Interactions/*immunology
Immediate-Early Proteins/*immunology
Nuclear Proteins/*immunology
Promyelocytic Leukemia Protein/*immunology
Transcription Factors/*immunology
Ubiquitin-Protein Ligases/*immunology
Cell Line, Tumor ; Epithelial Cells/immunology ; Epithelial Cells/virology ; Gene Expression Regulation ; Herpesvirus 1, Human/genetics ; Host-Pathogen Interactions/genetics ; Humans ; Immediate-Early Proteins/genetics ; Mutation ; Nuclear Proteins/genetics ; Promyelocytic Leukemia Protein/genetics ; Protein Binding ; Protein Isoforms/genetics ; Protein Isoforms/immunology ; Proteolysis ; Signal Transduction ; Sumoylation ; Transcription Factors/genetics ; Ubiquitin-Protein Ligases/genetics
Czasopismo naukowe
Tytuł :
EBV Rta-induced IL-6 Promotes Migration of Bystander Tumor Cells Through IL-6R/JAK/STAT3 Pathway In Vitro .
Autorzy :
Tung KL; Department of Dental Technology, Shu-Zen Junior College of Medicine and Management, Kaohsiung, Taiwan, R.O.C.
Wu YT; Department of Pathology, Golden Hospital, Pingtung, Taiwan, R.O.C.
Liu C; Department of Dental Technology, Shu-Zen Junior College of Medicine and Management, Kaohsiung, Taiwan, R.O.C.; Department of Health and Beauty, Shu-Zen Junior College of Medicine and Management, Kaohsiung, Taiwan, R.O.C.
Lin SC; Department of Dental Technology, Shu-Zen Junior College of Medicine and Management, Kaohsiung, Taiwan, R.O.C.
Wu CH; Department of Dental Technology, Shu-Zen Junior College of Medicine and Management, Kaohsiung, Taiwan, R.O.C.
Wu SY; Department of Pathology, Golden Hospital, Pingtung, Taiwan, R.O.C.
Chang Y; National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Tainan, Taiwan, R.O.C.
Lan YY; Department of Physical Therapy, Shu-Zen Junior College of Medicine and Management, Kaohsiung, Taiwan, R.O.C. .
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Źródło :
Anticancer research [Anticancer Res] 2020 Jun; Vol. 40 (6), pp. 3255-3264.
Typ publikacji :
Journal Article
MeSH Terms :
Immediate-Early Proteins/*metabolism
Interleukin-6/*metabolism
Janus Kinases/*metabolism
Neoplasms/*metabolism
Receptors, Interleukin-6/*metabolism
STAT3 Transcription Factor/*metabolism
Trans-Activators/*metabolism
Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Breast Neoplasms/virology ; Cell Line, Tumor ; Cell Movement/physiology ; Humans ; Immediate-Early Proteins/genetics ; Interleukin-6/biosynthesis ; Interleukin-6/genetics ; MAP Kinase Signaling System ; MCF-7 Cells ; Nasopharyngeal Carcinoma/genetics ; Nasopharyngeal Carcinoma/metabolism ; Nasopharyngeal Carcinoma/pathology ; Nasopharyngeal Carcinoma/virology ; Nasopharyngeal Neoplasms/genetics ; Nasopharyngeal Neoplasms/metabolism ; Nasopharyngeal Neoplasms/pathology ; Nasopharyngeal Neoplasms/virology ; Neoplasms/genetics ; Neoplasms/pathology ; Neoplasms/virology ; Signal Transduction ; Stomach Neoplasms/genetics ; Stomach Neoplasms/metabolism ; Stomach Neoplasms/pathology ; Stomach Neoplasms/virology ; Trans-Activators/genetics ; Transcription Factor AP-1/metabolism ; Transfection ; Up-Regulation
Czasopismo naukowe
Tytuł :
DDB1 E3 ligase controls dietary fructose-induced ChREBPα stabilization and liver steatosis via CRY1.
Autorzy :
Tong X; Department of Molecular & Integrative Physiology, University of Michigan Medical School, 1137 Catherine Street, Med Sci II 7712, Ann Arbor, MI 48109, USA.
Zhang D; Department of Molecular & Integrative Physiology, University of Michigan Medical School, 1137 Catherine Street, Med Sci II 7712, Ann Arbor, MI 48109, USA.
Shabandri O; Department of Molecular & Integrative Physiology, University of Michigan Medical School, 1137 Catherine Street, Med Sci II 7712, Ann Arbor, MI 48109, USA.
Oh J; Department of Molecular & Integrative Physiology, University of Michigan Medical School, 1137 Catherine Street, Med Sci II 7712, Ann Arbor, MI 48109, USA.
Jin E; Department of Molecular & Integrative Physiology, University of Michigan Medical School, 1137 Catherine Street, Med Sci II 7712, Ann Arbor, MI 48109, USA.
Stamper K; Department of Molecular & Integrative Physiology, University of Michigan Medical School, 1137 Catherine Street, Med Sci II 7712, Ann Arbor, MI 48109, USA.
Yang M; Department of Molecular & Integrative Physiology, University of Michigan Medical School, 1137 Catherine Street, Med Sci II 7712, Ann Arbor, MI 48109, USA; Department of Infectious Diseases, The Second Xianya Hospital, Central South University, Changsha City 410083, Hunan Province, PR China.
Zhao Z; Department of Molecular & Integrative Physiology, University of Michigan Medical School, 1137 Catherine Street, Med Sci II 7712, Ann Arbor, MI 48109, USA; Department of Pharmacology of Chinese Materia, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing City 211198, PR China.
Yin L; Department of Molecular & Integrative Physiology, University of Michigan Medical School, 1137 Catherine Street, Med Sci II 7712, Ann Arbor, MI 48109, USA. Electronic address: .
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Źródło :
Metabolism: clinical and experimental [Metabolism] 2020 Jun; Vol. 107, pp. 154222. Date of Electronic Publication: 2020 Apr 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/*metabolism
Cryptochromes/*genetics
DNA-Binding Proteins/*genetics
DNA-Binding Proteins/*metabolism
Dietary Carbohydrates/*pharmacology
Fatty Liver/*chemically induced
Fatty Liver/*genetics
Fructose/*pharmacology
Immediate-Early Proteins/*metabolism
Membrane Proteins/*metabolism
Animals ; Hepatocytes/metabolism ; Immediate-Early Proteins/genetics ; Lipogenesis/drug effects ; Lipogenesis/genetics ; Membrane Proteins/genetics ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mutation/genetics ; Primary Cell Culture ; Ubiquitination
Czasopismo naukowe
Tytuł :
Revisiting promyelocytic leukemia protein targeting by human cytomegalovirus immediate-early protein 1.
Autorzy :
Paulus C; Biomedical Sciences Research Complex, University of St Andrews, St Andrews, United Kingdom.
Harwardt T; Institute for Medical Microbiology and Hygiene, University of Regensburg, Regensburg, Germany.
Walter B; Biomedical Sciences Research Complex, University of St Andrews, St Andrews, United Kingdom.
Marxreiter A; Institute for Medical Microbiology and Hygiene, University of Regensburg, Regensburg, Germany.
Zenger M; Institute for Medical Microbiology and Hygiene, University of Regensburg, Regensburg, Germany.
Reuschel E; Department of Obstetrics and Gynecology, Clinic St. Hedwig at Hospital Barmherzige Brüder Regensburg, Regensburg, Germany.
Nevels MM; Biomedical Sciences Research Complex, University of St Andrews, St Andrews, United Kingdom.
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Źródło :
PLoS pathogens [PLoS Pathog] 2020 May 04; Vol. 16 (5), pp. e1008537. Date of Electronic Publication: 2020 May 04 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cytomegalovirus Infections*/genetics
Cytomegalovirus Infections*/immunology
Cytomegalovirus Infections*/pathology
Immediate-Early Proteins*/genetics
Immediate-Early Proteins*/immunology
Immunity, Innate*
Promyelocytic Leukemia Protein*/genetics
Promyelocytic Leukemia Protein*/immunology
Virus Replication*/genetics
Virus Replication*/immunology
Cytomegalovirus/*physiology
Cell Line ; Gene Expression Regulation, Viral/immunology ; Humans ; Mutation ; Sumoylation/immunology
Czasopismo naukowe
Tytuł :
S-Nitrosylation at the active site decreases the ubiquitin-conjugating activity of ubiquitin-conjugating enzyme E2 D1 (UBE2D1), an ERAD-associated protein.
Autorzy :
Fujikawa K; Department of Medicinal Pharmacology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-naka, Kita-ku, Okayama, 700-8530, Japan.
Nakahara K; Department of Medicinal Pharmacology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-naka, Kita-ku, Okayama, 700-8530, Japan.
Takasugi N; Department of Medicinal Pharmacology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-naka, Kita-ku, Okayama, 700-8530, Japan.
Nishiya T; Department of Medical Pharmacology, School of Pharmaceutical Sciences, Ohu University, 31-1 Misumido, Tomitamachi, Koriyama, Fukushima, 963-8611, Japan.
Ito A; School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo, 192-0355, Japan.
Uchida K; Laboratory of Food Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, 113-8657, Japan.
Uehara T; Department of Medicinal Pharmacology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-naka, Kita-ku, Okayama, 700-8530, Japan. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Apr 16; Vol. 524 (4), pp. 910-915. Date of Electronic Publication: 2020 Feb 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Processing, Post-Translational*
Immediate-Early Proteins/*metabolism
Protein-Serine-Threonine Kinases/*metabolism
Ubiquitin/*metabolism
Ubiquitin-Conjugating Enzymes/*metabolism
Ubiquitin-Protein Ligases/*metabolism
Autophagy/drug effects ; Autophagy/genetics ; Catalytic Domain ; Chromones/pharmacology ; Endoplasmic Reticulum/drug effects ; Endoplasmic Reticulum/metabolism ; Endoplasmic Reticulum Stress/drug effects ; Endoplasmic Reticulum Stress/genetics ; Endoplasmic Reticulum-Associated Degradation/drug effects ; Endoplasmic Reticulum-Associated Degradation/genetics ; HEK293 Cells ; Humans ; Immediate-Early Proteins/genetics ; Leupeptins/pharmacology ; Morpholines/pharmacology ; Nitrosative Stress ; Nitroso Compounds/metabolism ; Oxidation-Reduction/drug effects ; Phosphorylation ; Proteasome Endopeptidase Complex/drug effects ; Proteasome Endopeptidase Complex/metabolism ; Protein Folding ; Protein-Serine-Threonine Kinases/genetics ; Ubiquitin/genetics ; Ubiquitin-Conjugating Enzymes/genetics ; Ubiquitin-Protein Ligases/genetics ; Ubiquitination
Czasopismo naukowe
Tytuł :
Human cytomegalovirus long noncoding RNA4.9 regulates viral DNA replication.
Autorzy :
Tai-Schmiedel J; Weizmann Institute of Science, Department of Molecular Genetics, Rehovot, Israel.
Karniely S; Kimron Veterinary Institute, Bet Dagan, Israel.
Lau B; MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom.
Ezra A; Weizmann Institute of Science, Department of Molecular Genetics, Rehovot, Israel.
Eliyahu E; Weizmann Institute of Science, Department of Molecular Genetics, Rehovot, Israel.
Nachshon A; Weizmann Institute of Science, Department of Molecular Genetics, Rehovot, Israel.
Kerr K; MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom.
Suárez N; MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom.
Schwartz M; Weizmann Institute of Science, Department of Molecular Genetics, Rehovot, Israel.
Davison AJ; MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom.
Stern-Ginossar N; Weizmann Institute of Science, Department of Molecular Genetics, Rehovot, Israel.
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Źródło :
PLoS pathogens [PLoS Pathog] 2020 Apr 15; Vol. 16 (4), pp. e1008390. Date of Electronic Publication: 2020 Apr 15 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Replication*
Virus Replication*
Cytomegalovirus/*genetics
DNA, Viral/*genetics
Immediate-Early Proteins/*metabolism
RNA, Long Noncoding/*genetics
Viral Proteins/*genetics
Animals ; Cells, Cultured ; Cytomegalovirus Infections/genetics ; Cytomegalovirus Infections/microbiology ; Cytomegalovirus Infections/pathology ; Gene Expression Regulation, Viral ; Humans ; Immediate-Early Proteins/genetics ; Mice ; Replication Origin
Czasopismo naukowe
Tytuł :
Killer cell proteases can target viral immediate-early proteins to control human cytomegalovirus infection in a noncytotoxic manner.
Autorzy :
Shan L; Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands.
Li S; Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands.
Meeldijk J; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.
Blijenberg B; Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands.
Hendriks A; Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands.
van Boxtel KJWM; Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands.
van den Berg SPH; Department of Medicine, University of Cambridge, Cambridge, United Kingdom.
Groves IJ; Department of Medicine, University of Cambridge, Cambridge, United Kingdom.
Potts M; Department of Medicine, University of Cambridge, Cambridge, United Kingdom.
Svrlanska A; Institute of Clinical and Molecular Virology, University of Erlangen-Nuremberg, Erlangen, Germany.
Stamminger T; Institute for Virology, Ulm University Medical Center, Ulm, Germany.
Wills MR; Department of Medicine, University of Cambridge, Cambridge, United Kingdom.
Bovenschen N; Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands.; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.
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Źródło :
PLoS pathogens [PLoS Pathog] 2020 Apr 13; Vol. 16 (4), pp. e1008426. Date of Electronic Publication: 2020 Apr 13 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cytomegalovirus/*metabolism
Cytomegalovirus Infections/*enzymology
Granzymes/*metabolism
Immediate-Early Proteins/*metabolism
Killer Cells, Natural/*enzymology
Trans-Activators/*metabolism
Amino Acid Motifs ; Cytomegalovirus/genetics ; Cytomegalovirus Infections/virology ; Granzymes/genetics ; Host-Pathogen Interactions ; Humans ; Immediate-Early Proteins/genetics ; Proteolysis ; T-Lymphocytes, Cytotoxic/enzymology ; Trans-Activators/genetics
Czasopismo naukowe
Tytuł :
Human cytomegalovirus IE2 drives transcription initiation from a select subset of late infection viral promoters by host RNA polymerase II.
Autorzy :
Li M; Departments of Internal Medicine and Epidemiology, University of Iowa and Iowa City Veterans Affairs Health Care System, Iowa City, IA, United States of America.; Department of Biochemistry, University of Iowa, Iowa City, IA, United States of America.
Ball CB; Department of Biochemistry, University of Iowa, Iowa City, IA, United States of America.
Collins G; Department of Biochemistry, University of Iowa, Iowa City, IA, United States of America.
Hu Q; Departments of Internal Medicine and Epidemiology, University of Iowa and Iowa City Veterans Affairs Health Care System, Iowa City, IA, United States of America.
Luse DS; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States of America.
Price DH; Department of Biochemistry, University of Iowa, Iowa City, IA, United States of America.
Meier JL; Departments of Internal Medicine and Epidemiology, University of Iowa and Iowa City Veterans Affairs Health Care System, Iowa City, IA, United States of America.
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Źródło :
PLoS pathogens [PLoS Pathog] 2020 Apr 06; Vol. 16 (4), pp. e1008402. Date of Electronic Publication: 2020 Apr 06 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
DNA Replication*
Promoter Regions, Genetic*
Cytomegalovirus/*metabolism
Cytomegalovirus Infections/*virology
Immediate-Early Proteins/*metabolism
RNA Polymerase II/*metabolism
Trans-Activators/*metabolism
Viral Proteins/*genetics
Cytomegalovirus/genetics ; Cytomegalovirus Infections/genetics ; Cytomegalovirus Infections/metabolism ; DNA, Viral/genetics ; Gene Expression Regulation, Viral ; Humans ; Immediate-Early Proteins/genetics ; RNA Polymerase II/genetics ; Trans-Activators/genetics ; Transcription Initiation, Genetic ; Viral Proteins/metabolism ; Virus Replication
Czasopismo naukowe
Tytuł :
mRNA destabilization by BTG1 and BTG2 maintains T cell quiescence.
Autorzy :
Hwang SS; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA.
Lim J; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA.
Yu Z; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA.; Shanghai Institute of Immunology, Department of Microbiology and Immunology, Shanghai Jiao Tong University School of Medicine (SJTU-SM), Shanghai 200025, China.; Yale Center for ImmunoMetabolism, Shanghai Jiao Tong University School of Medicine (SJTU-SM), Shanghai 200025, China.
Kong P; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA.
Sefik E; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA.
Xu H; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA.
Harman CCD; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA.
Kim LK; Severance Biomedical Science Institute and BK21 PLUS Project for Medical Sciences, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 06230, Republic of Korea.
Lee GR; Department of Life Science, Sogang University, Seoul 04107, Republic of Korea.
Li HB; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA.; Shanghai Institute of Immunology, Department of Microbiology and Immunology, Shanghai Jiao Tong University School of Medicine (SJTU-SM), Shanghai 200025, China.; Yale Center for ImmunoMetabolism, Shanghai Jiao Tong University School of Medicine (SJTU-SM), Shanghai 200025, China.
Flavell RA; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA. .; Howard Hughes Medical Institute, Chevy Chase, MD 20815-6789, USA.
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Źródło :
Science (New York, N.Y.) [Science] 2020 Mar 13; Vol. 367 (6483), pp. 1255-1260.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Lymphocyte Activation*
RNA Stability*
Immediate-Early Proteins/*physiology
Neoplasm Proteins/*physiology
RNA, Messenger/*chemistry
T-Lymphocytes/*immunology
Tumor Suppressor Proteins/*physiology
Animals ; Cells, Cultured ; Immediate-Early Proteins/genetics ; Mice ; Mice, Knockout ; Neoplasm Proteins/genetics ; Polyadenylation ; Tumor Suppressor Proteins/genetics
Czasopismo naukowe
Tytuł :
A fail-safe system to prevent oncogenesis by senescence is targeted by SV40 small T antigen.
Autorzy :
Oshikawa K; Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
Matsumoto M; Division of Proteomics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan. .
Kodama M; Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
Shimizu H; Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
Nakayama KI; Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan. .; Division of Proteomics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan. .
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Źródło :
Oncogene [Oncogene] 2020 Mar; Vol. 39 (10), pp. 2170-2186. Date of Electronic Publication: 2019 Dec 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antigens, Viral, Tumor/*metabolism
Carcinogenesis/*genetics
Immediate-Early Proteins/*metabolism
Nuclear Proteins/*metabolism
Polyomavirus Infections/*complications
Simian virus 40/*metabolism
Tumor Suppressor Proteins/*metabolism
Tumor Virus Infections/*complications
Cell Line ; Cellular Senescence/genetics ; Fibroblasts ; Gene Expression Regulation ; Humans ; Immediate-Early Proteins/genetics ; Retinoblastoma Protein ; Signal Transduction ; Tumor Suppressor Protein p53 ; Tumor Suppressor Proteins/genetics
Czasopismo naukowe
Tytuł :
Virtual Screening Approach to Identify High-Affinity Inhibitors of Serum and Glucocorticoid-Regulated Kinase 1 among Bioactive Natural Products: Combined Molecular Docking and Simulation Studies.
Autorzy :
Mohammad T; Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India.
Siddiqui S; Department of Biotechnology, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India.
Shamsi A; Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India.
Alajmi MF; Department of Pharmacognosy College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Hussain A; Department of Pharmacognosy College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Islam A; Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India.
Ahmad F; Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India.
Hassan MI; Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2020 Feb 13; Vol. 25 (4). Date of Electronic Publication: 2020 Feb 13.
Typ publikacji :
Journal Article
MeSH Terms :
Molecular Dynamics Simulation*
Biological Products/*chemistry
Enzyme Inhibitors/*chemistry
Enzyme Inhibitors/*pharmacology
Immediate-Early Proteins/*chemistry
Immediate-Early Proteins/*metabolism
Protein-Serine-Threonine Kinases/*chemistry
Protein-Serine-Threonine Kinases/*metabolism
Humans ; Immediate-Early Proteins/antagonists & inhibitors ; Protein Structure, Secondary ; Protein-Serine-Threonine Kinases/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
Herpes simplex virus blocks host transcription termination via the bimodal activities of ICP27.
Autorzy :
Wang X; Department of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, Irvine, CA, 92697, USA.
Hennig T; Institute for Virology and Immunobiology, Julius-Maximilians-University Würzburg, Würzburg, Germany.
Whisnant AW; Institute for Virology and Immunobiology, Julius-Maximilians-University Würzburg, Würzburg, Germany.
Erhard F; Institute for Virology and Immunobiology, Julius-Maximilians-University Würzburg, Würzburg, Germany.
Prusty BK; Institute for Virology and Immunobiology, Julius-Maximilians-University Würzburg, Würzburg, Germany.
Friedel CC; Institute of Informatics, Ludwig-Maximilians-Universität München, München, Germany.
Forouzmand E; Institute for Genomics and Bioinformatics, University of California, Irvine, Irvine, CA, 92697, USA.; Department of Computer Science, University of California, Irvine, Irvine, CA, 92697, USA.
Hu W; Department of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, Irvine, CA, 92697, USA.
Erber L; Department of Biochemistry, Molecular Biology, and Biophysics, College of Biological Sciences, University of Minnesota, Saint Paul, MN, 55018, USA.
Chen Y; Department of Biochemistry, Molecular Biology, and Biophysics, College of Biological Sciences, University of Minnesota, Saint Paul, MN, 55018, USA.
Sandri-Goldin RM; Department of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, Irvine, CA, 92697, USA. .
Dölken L; Institute for Virology and Immunobiology, Julius-Maximilians-University Würzburg, Würzburg, Germany. .; Helmholtz Institute for RNA-based Infection Research, Würzburg, Germany. .
Shi Y; Department of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, Irvine, CA, 92697, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Jan 15; Vol. 11 (1), pp. 293. Date of Electronic Publication: 2020 Jan 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription Termination, Genetic*
Herpesvirus 1, Human/*pathogenicity
Host-Pathogen Interactions/*physiology
Immediate-Early Proteins/*metabolism
Animals ; Cell Line ; Cleavage And Polyadenylation Specificity Factor/metabolism ; HeLa Cells ; Herpes Simplex/genetics ; Herpes Simplex/virology ; Herpesvirus 1, Human/genetics ; Host-Pathogen Interactions/genetics ; Humans ; Immediate-Early Proteins/genetics ; Immediate-Early Proteins/physiology ; RNA Processing, Post-Transcriptional ; RNA, Messenger/genetics
Czasopismo naukowe
Tytuł :
Human cytomegalovirus IE86 protein aa 136-289 mediates STING degradation and blocks the cGAS-STING pathway.
Autorzy :
Lee JK; Department of Life Science, Gachon University, Seongnam, 13120, Republic of Korea.
Kim JE; Department of Life Science, Gachon University, Seongnam, 13120, Republic of Korea.; Program in Developmental & Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, M5G 0A4, Canada.
Park BJ; Department of Electronic Engineering, Gachon University, Seongnam, 13120, Republic of Korea.
Song YJ; Department of Life Science, Gachon University, Seongnam, 13120, Republic of Korea. .
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Źródło :
Journal of microbiology (Seoul, Korea) [J Microbiol] 2020 Jan; Vol. 58 (1), pp. 54-60. Date of Electronic Publication: 2020 Jan 02.
Typ publikacji :
Journal Article
MeSH Terms :
Immediate-Early Proteins*/immunology
Immediate-Early Proteins*/metabolism
Trans-Activators*/immunology
Trans-Activators*/metabolism
Viral Proteins*/immunology
Viral Proteins*/metabolism
Cytomegalovirus/*immunology
Cytomegalovirus Infections/*immunology
Membrane Proteins/*immunology
Nucleotidyltransferases/*immunology
HEK293 Cells ; Humans ; Membrane Proteins/metabolism ; Nucleotidyltransferases/metabolism ; Protein Binding
Czasopismo naukowe
Tytuł :
The Herpes Simplex Virus 1 Immediate Early Protein ICP22 Is a Functional Mimic of a Cellular J Protein.
Autorzy :
Adlakha M; Department of Molecular Biology and Biophysics and Molecular Biology and Biochemistry Graduate Program, University of Connecticut School of Medicine, Farmington, Connecticut, USA.
Livingston CM; Department of Molecular Biology and Biophysics and Molecular Biology and Biochemistry Graduate Program, University of Connecticut School of Medicine, Farmington, Connecticut, USA.
Bezsonova I; Department of Molecular Biology and Biophysics and Molecular Biology and Biochemistry Graduate Program, University of Connecticut School of Medicine, Farmington, Connecticut, USA.
Weller SK; Department of Molecular Biology and Biophysics and Molecular Biology and Biochemistry Graduate Program, University of Connecticut School of Medicine, Farmington, Connecticut, USA .
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Źródło :
Journal of virology [J Virol] 2020 Jan 31; Vol. 94 (4). Date of Electronic Publication: 2020 Jan 31 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
HSP40 Heat-Shock Proteins/*metabolism
Herpesvirus 1, Human/*metabolism
Immediate-Early Proteins/*metabolism
Animals ; Cell Nucleus/metabolism ; Chlorocebus aethiops ; HEK293 Cells ; Herpes Simplex/virology ; Herpesvirus 1, Human/pathogenicity ; Herpesvirus 1, Human/physiology ; Humans ; Immediate-Early Proteins/genetics ; Molecular Chaperones/metabolism ; Phosphorylation ; Protein Folding ; RNA Polymerase II/metabolism ; Vero Cells ; Viral Proteins/metabolism
Czasopismo naukowe
Tytuł :
Human cytomegalovirus IE2 protein regulates macrophage-mediated immune escape by upregulating GRB2 expression in UL122 genetically modified mice.
Autorzy :
Yang Y; Department of Special Medicine, Qingdao University College of Medicine, Qingdao, China.
Ren G; Dermatology, Heze Municipal Hospital, Heze, China.
Wang Z; Department of Pathogen Biology, Qingdao University College of Medicine, Qingdao, China.
Wang B; Department of Special Medicine, Qingdao University College of Medicine, Qingdao, China.
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Źródło :
Bioscience trends [Biosci Trends] 2020 Jan 20; Vol. 13 (6), pp. 502-509. Date of Electronic Publication: 2019 Dec 23.
Typ publikacji :
Journal Article
MeSH Terms :
GRB2 Adaptor Protein/*metabolism
Immediate-Early Proteins/*metabolism
Macrophages/*metabolism
Phagocytosis/*physiology
Trans-Activators/*metabolism
Animals ; Blotting, Western ; Cells, Cultured ; Female ; Flow Cytometry ; GRB2 Adaptor Protein/genetics ; Immediate-Early Proteins/genetics ; Macrophages/cytology ; Male ; Mice ; Mice, Transgenic ; Phagocytosis/genetics ; Real-Time Polymerase Chain Reaction ; Trans-Activators/genetics
Czasopismo naukowe
Tytuł :
Duplicate US1 Genes of Duck Enteritis Virus Encode a Non-essential Immediate Early Protein Localized to the Nucleus.
Autorzy :
Li Y; Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, China.; Avian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, China.; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, China.
Wu Y; Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, China.; Avian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, China.; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, China.
Wang M; Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, China.; Avian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, China.; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, China.
Ma Y; Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, China.; Avian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, China.; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, China.
Jia R; Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, China.; Avian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, China.; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, China.
Chen S; Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, China.; Avian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, China.; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, China.
Zhu D; Avian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, China.; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, China.
Liu M; Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, China.; Avian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, China.; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, China.
Yang Q; Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, China.; Avian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, China.; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, China.
Zhao X; Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, China.; Avian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, China.; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, China.
Zhang S; Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, China.; Avian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, China.; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, China.
Huang J; Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, China.; Avian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, China.; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, China.
Ou X; Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, China.; Avian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, China.; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, China.
Mao S; Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, China.; Avian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, China.; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, China.
Zhang L; Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, China.; Avian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, China.; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, China.
Liu Y; Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, China.; Avian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, China.; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, China.
Yu Y; Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, China.; Avian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, China.; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, China.
Pan L; Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, China.; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, China.
Tian B; Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, China.; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, China.
Rehman MU; Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, China.; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, China.
Chen X; Avian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, China.; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, China.
Cheng A; Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, China.; Avian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, China.; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, China.
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Źródło :
Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2020 Jan 17; Vol. 9, pp. 463. Date of Electronic Publication: 2020 Jan 17 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Nucleus/*metabolism
Enteritis/*virology
Herpesvirus 1, Human/*genetics
Immediate-Early Proteins/*genetics
Animals ; Antibodies, Viral ; DNA, Viral ; Ducks ; Fibroblasts ; Gene Deletion ; Immediate-Early Proteins/metabolism ; Kinetics ; Poultry Diseases/virology ; Recombinant Proteins ; Viral Proteins/chemistry ; Viral Proteins/genetics ; Viral Proteins/metabolism ; Virus Replication
Czasopismo naukowe
Tytuł :
Nuclear import of IER5 is mediated by a classical bipartite nuclear localization signal and is required for HSF1 full activation.
Autorzy :
Yamano S; Laboratory of Fundamental Oncology, National Cancer Center Research Institute, Tsukiji 5-1-1, Chuo-ku, Tokyo, 104-0045, Japan.
Kimura M; Cellular Dynamics Laboratory, Cluster for Pioneering Research, RIKEN, 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan.
Chen Y; Laboratory of Fundamental Oncology, National Cancer Center Research Institute, Tsukiji 5-1-1, Chuo-ku, Tokyo, 104-0045, Japan.
Imamoto N; Cellular Dynamics Laboratory, Cluster for Pioneering Research, RIKEN, 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan.
Ohki R; Laboratory of Fundamental Oncology, National Cancer Center Research Institute, Tsukiji 5-1-1, Chuo-ku, Tokyo, 104-0045, Japan. Electronic address: .
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Źródło :
Experimental cell research [Exp Cell Res] 2020 Jan 01; Vol. 386 (1), pp. 111686. Date of Electronic Publication: 2019 Nov 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Nuclear Localization Signals*
Cell Nucleus/*metabolism
Immediate-Early Proteins/*metabolism
Nuclear Proteins/*metabolism
Active Transport, Cell Nucleus ; Cell Line, Tumor ; Conserved Sequence ; HEK293 Cells ; Heat Shock Transcription Factors/metabolism ; Humans ; Immediate-Early Proteins/chemistry ; Karyopherins/metabolism ; Nuclear Proteins/chemistry ; Phosphorylation
Czasopismo naukowe
Tytuł :
Knockdown of SGK1 alleviates the IL-1β-induced chondrocyte anabolic and catabolic imbalance by activating FoxO1-mediated autophagy in human chondrocytes.
Autorzy :
Huang W; Department of Orthopaedics, The First Affiliated Hospital of Anhui Medical University, Hefei, China.; Department of Orthopaedics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Cheng C; Department of Orthopaedics, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Shan WS; Department of Orthopaedics, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Ding ZF; Department of Orthopaedics, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Liu FE; Department of Orthopaedics, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Lu W; Department of Orthopaedics, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
He W; School of Basic Medical Sciences, Anhui Medical University, Hefei, China.
Xu JG; School of Basic Medical Sciences, Anhui Medical University, Hefei, China.
Yin ZS; Department of Orthopaedics, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
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Źródło :
The FEBS journal [FEBS J] 2020 Jan; Vol. 287 (1), pp. 94-107. Date of Electronic Publication: 2019 Jul 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Autophagy*
Chondrocytes/*pathology
Forkhead Box Protein O1/*metabolism
Immediate-Early Proteins/*metabolism
Interleukin-1beta/*pharmacology
Osteoarthritis/*metabolism
Osteoarthritis/*pathology
Protein-Serine-Threonine Kinases/*metabolism
ADAMTS5 Protein/genetics ; ADAMTS5 Protein/metabolism ; Aged ; Aggrecans/genetics ; Aggrecans/metabolism ; Cells, Cultured ; Chondrocytes/drug effects ; Chondrocytes/metabolism ; Collagen Type II/genetics ; Collagen Type II/metabolism ; Forkhead Box Protein O1/genetics ; Humans ; Immediate-Early Proteins/genetics ; Male ; Matrix Metalloproteinase 13/genetics ; Matrix Metalloproteinase 13/metabolism ; Osteoarthritis/genetics ; Phosphorylation ; Protein Transport ; Protein-Serine-Threonine Kinases/genetics
Czasopismo naukowe

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