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Wyszukujesz frazę ""Immunity, Innate"" wg kryterium: Temat


Tytuł :
Epigenetically regulated digital signaling defines epithelial innate immunity at the tissue level.
Autorzy :
Clark HR; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Oncology Department, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; The Biochemistry, Cellular, and Molecular Biology Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
McKenney C; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Oncology Department, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; The Biochemistry, Cellular, and Molecular Biology Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Livingston NM; The Biochemistry, Cellular, and Molecular Biology Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Gershman A; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; The Biochemistry, Cellular, and Molecular Biology Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Sajjan S; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Oncology Department, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Chan IS; Oncology Department, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Ewald AJ; Oncology Department, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Timp W; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Wu B; Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Singh A; Electrical and Computer Engineering, University of Delaware, Newark, DE, USA.
Regot S; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA. .; Oncology Department, Johns Hopkins University School of Medicine, Baltimore, MD, USA. .; Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Mar 23; Vol. 12 (1), pp. 1836. Date of Electronic Publication: 2021 Mar 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Immunity, Innate*/drug effects
Immunity, Innate*/genetics
Bacteria/*immunology
Epithelial Cells/*immunology
Lipopeptides/*immunology
NF-kappa B/*metabolism
Toll-Like Receptor 2/*metabolism
Animals ; Bacteria/metabolism ; Cell Line ; Cytokines/metabolism ; Cytokines/pharmacology ; DNA Methylation/drug effects ; Epigenesis, Genetic/drug effects ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism ; Flagellin/pharmacology ; Gene Expression Regulation/genetics ; Gene Expression Regulation/immunology ; Humans ; Image Processing, Computer-Assisted ; In Situ Hybridization, Fluorescence ; Mammary Glands, Animal ; Mice ; Organoids/drug effects ; Organoids/immunology ; Organoids/metabolism ; Promoter Regions, Genetic ; RNA-Seq ; Signal Transduction/immunology ; Single-Cell Analysis ; Toll-Like Receptor 2/agonists ; Toll-Like Receptor 2/genetics ; Toll-Like Receptors/agonists ; Toll-Like Receptors/metabolism
Czasopismo naukowe
Tytuł :
SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial-derived cells and cardiomyocytes.
Autorzy :
Li Y; Department of Microbiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104; .; Penn Center for Research on Coronaviruses and Other Emerging Pathogens, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104.
Renner DM; Department of Microbiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104.; Penn Center for Research on Coronaviruses and Other Emerging Pathogens, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104.
Comar CE; Department of Microbiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104.; Penn Center for Research on Coronaviruses and Other Emerging Pathogens, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104.
Whelan JN; Department of Microbiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104.; Penn Center for Research on Coronaviruses and Other Emerging Pathogens, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104.
Reyes HM; Department of Microbiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104.; Penn Center for Research on Coronaviruses and Other Emerging Pathogens, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104.
Cardenas-Diaz FL; Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104.; Penn-CHOP Lung Biology Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104.
Truitt R; Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104.; Institute for Regenerative Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104.
Tan LH; Department of Otorhinolaryngology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104.
Dong B; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195.
Alysandratos KD; Department of Medicine, The Pulmonary Center, Center for Regenerative Medicine, Boston University School of Medicine, Boston, MA 02118.
Huang J; Department of Medicine, The Pulmonary Center, Center for Regenerative Medicine, Boston University School of Medicine, Boston, MA 02118.
Palmer JN; Department of Otorhinolaryngology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104.
Adappa ND; Department of Otorhinolaryngology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104.
Kohanski MA; Department of Otorhinolaryngology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104.
Kotton DN; Department of Medicine, The Pulmonary Center, Center for Regenerative Medicine, Boston University School of Medicine, Boston, MA 02118.
Silverman RH; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195.
Yang W; Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104.
Morrisey EE; Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104.; Penn-CHOP Lung Biology Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104.
Cohen NA; Department of Otorhinolaryngology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104.; Division of Otolaryngology, Department of Surgery, Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA 19104.; Monell Chemical Senses Center, Philadelphia, PA 19104.
Weiss SR; Department of Microbiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104; .; Penn Center for Research on Coronaviruses and Other Emerging Pathogens, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Apr 20; Vol. 118 (16).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Immunity, Innate*
Epithelial Cells/*immunology
Epithelial Cells/*virology
Lung/*pathology
Myocytes, Cardiac/*immunology
Myocytes, Cardiac/*virology
RNA, Double-Stranded/*metabolism
SARS-CoV-2/*immunology
A549 Cells ; Endoribonucleases/metabolism ; Humans ; Middle East Respiratory Syndrome Coronavirus/immunology ; Middle East Respiratory Syndrome Coronavirus/physiology ; Nose/virology ; Virus Replication ; eIF-2 Kinase
Czasopismo naukowe
Tytuł :
COVID-19 and the human innate immune system.
Autorzy :
Schultze JL; Systems Medicine, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany; PRECISE Platform for Single Cell Genomics and Epigenomics at the DZNE and the University of Bonn, Bonn, Germany; Genomics and Immunoregulation, Life and Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany. Electronic address: .
Aschenbrenner AC; Systems Medicine, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany; PRECISE Platform for Single Cell Genomics and Epigenomics at the DZNE and the University of Bonn, Bonn, Germany; Genomics and Immunoregulation, Life and Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.
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Źródło :
Cell [Cell] 2021 Apr 01; Vol. 184 (7), pp. 1671-1692. Date of Electronic Publication: 2021 Feb 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Host Microbial Interactions*
Immunity, Innate*
COVID-19/*immunology
SARS-CoV-2/*physiology
Humans ; Severity of Illness Index
Czasopismo naukowe
Tytuł :
ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity.
Autorzy :
Liu G; Florida Research and Innovation Center, Cleveland Clinic, Port St Lucie, FL, USA.; Department of Microbiology, University of Chicago, Chicago, IL, USA.
Lee JH; Florida Research and Innovation Center, Cleveland Clinic, Port St Lucie, FL, USA.; Department of Microbiology, University of Chicago, Chicago, IL, USA.
Parker ZM; Department of Microbiology, University of Chicago, Chicago, IL, USA.
Acharya D; Florida Research and Innovation Center, Cleveland Clinic, Port St Lucie, FL, USA.; Department of Microbiology, University of Chicago, Chicago, IL, USA.
Chiang JJ; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, USA.
van Gent M; Florida Research and Innovation Center, Cleveland Clinic, Port St Lucie, FL, USA.; Department of Microbiology, University of Chicago, Chicago, IL, USA.
Riedl W; Florida Research and Innovation Center, Cleveland Clinic, Port St Lucie, FL, USA.; Department of Microbiology, University of Chicago, Chicago, IL, USA.
Davis-Gardner ME; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, USA.
Wies E; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, USA.
Chiang C; Florida Research and Innovation Center, Cleveland Clinic, Port St Lucie, FL, USA.; Department of Microbiology, University of Chicago, Chicago, IL, USA.
Gack MU; Florida Research and Innovation Center, Cleveland Clinic, Port St Lucie, FL, USA. .; Department of Microbiology, University of Chicago, Chicago, IL, USA. .
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Źródło :
Nature microbiology [Nat Microbiol] 2021 Apr; Vol. 6 (4), pp. 467-478. Date of Electronic Publication: 2021 Mar 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Immunity, Innate*
Coronavirus Papain-Like Proteases/*metabolism
Cytokines/*metabolism
Interferon-Induced Helicase, IFIH1/*antagonists & inhibitors
SARS-CoV-2/*enzymology
SARS-CoV-2/*immunology
Ubiquitins/*metabolism
Aedes ; Animals ; Chlorocebus aethiops ; Cricetinae ; HEK293 Cells ; Humans ; Interferon-Induced Helicase, IFIH1/metabolism ; Leukocytes, Mononuclear ; Mice ; Vero Cells
Czasopismo naukowe
Tytuł :
Atherosclerosis and Inflammatory Bowel Disease-Shared Pathogenesis and Implications for Treatment.
Autorzy :
Kamperidis N; 3749St Mark's Hospital, Harrow, London, United Kingdom.;   Nikolaos Kamperidis and Vasileios Kamperidis are sharing first authorship.
Kamperidis V; 1st Cardiology Department, 37788AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.;   Nikolaos Kamperidis and Vasileios Kamperidis are sharing first authorship.
Zegkos T; 1st Cardiology Department, 37788AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Kostourou I; 3749St Mark's Hospital, Harrow, London, United Kingdom.
Nikolaidou O; Radiology Department, Pananikolaou General Hospital, Thessaloniki, Greece.
Arebi N; 3749St Mark's Hospital, Harrow, London, United Kingdom.
Karvounis H; 1st Cardiology Department, 37788AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
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Źródło :
Angiology [Angiology] 2021 Apr; Vol. 72 (4), pp. 303-314. Date of Electronic Publication: 2020 Dec 02.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Adaptive Immunity*
Immunity, Innate*
Life Style*
Polymorphism, Single Nucleotide*
Atherosclerosis/*etiology
Inflammatory Bowel Diseases/*etiology
Animals ; Atherosclerosis/genetics ; Atherosclerosis/immunology ; Atherosclerosis/therapy ; Gastrointestinal Microbiome ; Genetic Predisposition to Disease ; Humans ; Inflammatory Bowel Diseases/genetics ; Inflammatory Bowel Diseases/immunology ; Inflammatory Bowel Diseases/therapy ; Phenotype ; Polymorphism, Genetic ; Risk Assessment ; Risk Factors ; Vitamin D/immunology
Czasopismo naukowe
Tytuł :
An Overview of Current Knowledge of Deadly CoVs and Their Interface with Innate Immunity.
Autorzy :
Zhang Y; Viral Immunology Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, D02 R590 Dublin, Ireland.
Gargan S; Viral Immunology Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, D02 R590 Dublin, Ireland.
Lu Y; Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK.
Stevenson NJ; Viral Immunology Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, D02 R590 Dublin, Ireland.; Viral Immunology Group, Royal College of Surgeons in Ireland-Medical University of Bahrain, Adliya 15503, Bahrain.
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Źródło :
Viruses [Viruses] 2021 Mar 26; Vol. 13 (4). Date of Electronic Publication: 2021 Mar 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Immunity, Innate*
COVID-19/*immunology
SARS-CoV-2/*immunology
Animals ; COVID-19/epidemiology ; COVID-19/mortality ; COVID-19/virology ; Humans ; SARS-CoV-2/genetics
Czasopismo naukowe
Tytuł :
The intractum from the Eleutherococcus senticosus fruits affects the innate immunity in human leukocytes: From the ethnomedicinal use to contemporary evidence-based research.
Autorzy :
Graczyk F; Department of Pharmaceutical Botany and Pharmacognosy, Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, 9 Marie Curie-Skłodowska Street, 85-094, Bydgoszcz, Poland.
Orzechowska B; Hirszfeld Institute of Immunology and Experimental Therapy (IIET) Polish Academy of Sciences, Wroclaw, Poland.
Franz D; Hirszfeld Institute of Immunology and Experimental Therapy (IIET) Polish Academy of Sciences, Wroclaw, Poland.
Strzemski M; Department of Analytical Chemistry, Medical University of Lublin, Chodźki 4a, 20-093 Lublin, Poland.
Verpoorte R; Natural Products Laboratory, Institute of Biology, Leiden University, 2300 RA, Leiden, the Netherlands.
Załuski D; Department of Pharmaceutical Botany and Pharmacognosy, Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, 9 Marie Curie-Skłodowska Street, 85-094, Bydgoszcz, Poland. Electronic address: .
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Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2021 Mar 25; Vol. 268, pp. 113636. Date of Electronic Publication: 2020 Dec 01.
Typ publikacji :
Journal Article
MeSH Terms :
Eleutherococcus*
Evidence-Based Medicine/*methods
Immunity, Innate/*drug effects
Leukocytes/*drug effects
Medicine, Traditional/*methods
Plant Extracts/*pharmacology
A549 Cells ; Fruit ; Humans ; Immunity, Innate/immunology ; Leukocytes/immunology ; Plant Extracts/immunology ; Plant Extracts/isolation & purification
Czasopismo naukowe
Tytuł :
Carvacrol inhibits the excessive immune response induced by influenza virus A via suppressing viral replication and TLR/RLR pattern recognition.
Autorzy :
Zheng K; College of Traditional Chinese Medicine, Jinan University, Guangzhou, China; The Hospital of the People's Liberation Army's 83rd Group, Xinxiang, China. Electronic address: .
Wu SZ; College of Traditional Chinese Medicine, Jinan University, Guangzhou, China. Electronic address: .
Lv YW; College of Traditional Chinese Medicine, Jinan University, Guangzhou, China. Electronic address: .
Pang P; College of Traditional Chinese Medicine, Jinan University, Guangzhou, China. Electronic address: .
Deng L; College of Traditional Chinese Medicine, Jinan University, Guangzhou, China. Electronic address: .
Xu HC; College of Traditional Chinese Medicine, Jinan University, Guangzhou, China. Electronic address: .
Shi YC; College of Traditional Chinese Medicine, Jinan University, Guangzhou, China. Electronic address: .
Chen XY; College of Traditional Chinese Medicine, Jinan University, Guangzhou, China. Electronic address: .
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Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2021 Mar 25; Vol. 268, pp. 113555. Date of Electronic Publication: 2020 Nov 02.
Typ publikacji :
Journal Article
MeSH Terms :
Cymenes/*pharmacology
DEAD Box Protein 58/*antagonists & inhibitors
Immunity, Innate/*drug effects
Influenzavirus A/*drug effects
Membrane Glycoproteins/*antagonists & inhibitors
Toll-Like Receptor 7/*antagonists & inhibitors
Virus Replication/*drug effects
Acute Lung Injury/drug therapy ; Acute Lung Injury/immunology ; Acute Lung Injury/metabolism ; Animals ; Cymenes/therapeutic use ; DEAD Box Protein 58/immunology ; DEAD Box Protein 58/metabolism ; Female ; Immunity, Innate/immunology ; Influenzavirus A/immunology ; Influenzavirus A/metabolism ; Membrane Glycoproteins/immunology ; Membrane Glycoproteins/metabolism ; Mice ; Mice, Inbred C57BL ; T-Lymphocytes, Helper-Inducer/drug effects ; T-Lymphocytes, Helper-Inducer/immunology ; T-Lymphocytes, Helper-Inducer/metabolism ; Toll-Like Receptor 7/immunology ; Toll-Like Receptor 7/metabolism ; Virus Replication/immunology
Czasopismo naukowe
Tytuł :
Unique and complementary suppression of cGAS-STING and RNA sensing- triggered innate immune responses by SARS-CoV-2 proteins.
Autorzy :
Rui Y; Cancer Institute, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Su J; Cancer Institute, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Shen S; Cancer Institute, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Hu Y; Cancer Institute, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Huang D; Cancer Institute, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Zheng W; Cancer Institute, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Lou M; Cancer Institute, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Shi Y; Cancer Institute, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Wang M; Cancer Institute, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Chen S; Cancer Institute, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Zhao N; Cancer Institute, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Dong Q; Cancer Institute, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Cai Y; School of Life Science, Jilin University, Changchun, China.
Xu R; Department of Hematology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Zheng S; Cancer Institute, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Yu XF; Cancer Institute, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China. .
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Źródło :
Signal transduction and targeted therapy [Signal Transduct Target Ther] 2021 Mar 15; Vol. 6 (1), pp. 123. Date of Electronic Publication: 2021 Mar 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunity, Innate*
Membrane Proteins/*immunology
Nucleotidyltransferases/*immunology
RNA, Viral/*immunology
SARS-CoV-2/*immunology
Signal Transduction/*immunology
Viral Proteins/*immunology
A549 Cells ; Animals ; Chickens ; HEK293 Cells ; HeLa Cells ; Humans ; Ligases/immunology ; Mice
Czasopismo naukowe
Tytuł :
SARS-CoV-2 non-structural protein 13 (nsp13) hijacks host deubiquitinase USP13 and counteracts host antiviral immune response.
Autorzy :
Guo G; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.; Department of Oncology, Mayo Clinic, Rochester, MN, USA.
Gao M; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.; Department of Oncology, Mayo Clinic, Rochester, MN, USA.
Gao X; Thoracic Diseases Research Unit, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.; Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.
Zhu B; Thoracic Diseases Research Unit, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.; Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.
Huang J; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.; Department of Oncology, Mayo Clinic, Rochester, MN, USA.
Luo K; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.; Department of Oncology, Mayo Clinic, Rochester, MN, USA.
Zhang Y; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.; Department of Oncology, Mayo Clinic, Rochester, MN, USA.
Sun J; Thoracic Diseases Research Unit, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.; Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.
Deng M; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.; Department of Oncology, Mayo Clinic, Rochester, MN, USA.
Lou Z; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA. .; Department of Oncology, Mayo Clinic, Rochester, MN, USA. .
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Źródło :
Signal transduction and targeted therapy [Signal Transduct Target Ther] 2021 Mar 11; Vol. 6 (1), pp. 119. Date of Electronic Publication: 2021 Mar 11.
Typ publikacji :
Letter; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunity, Innate*
COVID-19/*immunology
SARS-CoV-2/*immunology
Ubiquitin-Specific Proteases/*immunology
Viral Nonstructural Proteins/*immunology
A549 Cells ; COVID-19/genetics ; COVID-19/pathology ; HEK293 Cells ; Humans ; SARS-CoV-2/genetics ; Ubiquitin-Specific Proteases/genetics ; Viral Nonstructural Proteins/genetics
Raport
Tytuł :
SARS-CoV-2 infection and the antiviral innate immune response.
Autorzy :
Yang H; Department of Neurosurgery, Huashan Hospital, Institute for Translational Brain Research, MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai 200032, China.; Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Lyu Y; Department of Neurosurgery, Huashan Hospital, Institute for Translational Brain Research, MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai 200032, China.; Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Hou F; State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences; University of Chinese Academy of Sciences, Shanghai 200031, China.; School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.
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Źródło :
Journal of molecular cell biology [J Mol Cell Biol] 2021 Mar 10; Vol. 12 (12), pp. 963-967.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Immunity, Innate*
COVID-19/*immunology
SARS-CoV-2/*immunology
Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; COVID-19/virology ; Genome, Viral ; Host Microbial Interactions/immunology ; Humans ; Interferon Type I/immunology ; Interferon Type I/therapeutic use ; Models, Immunological ; Pandemics ; SARS-CoV-2/genetics ; Signal Transduction ; Viral Proteins/genetics
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
The equine mononuclear phagocyte system: The relevance of the horse as a model for understanding human innate immunity.
Autorzy :
Karagianni AE; The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian, UK.
Lisowski ZM; The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian, UK.
Hume DA; Mater Research Institute-UQ, Translational Research Institute, Woolloongabba, QLD, Australia.
Scott Pirie R; The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian, UK.
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Źródło :
Equine veterinary journal [Equine Vet J] 2021 Mar; Vol. 53 (2), pp. 231-249. Date of Electronic Publication: 2020 Sep 28.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Immunity, Innate*
Mononuclear Phagocyte System*
Animals ; Horses ; Humans ; Macrophages ; Mice ; Monocytes ; Transcriptome
Czasopismo naukowe
Tytuł :
Background immunity: How important is it for SARS-CoV-2?
Autorzy :
Silva Júnior JVJ; Virology Sector, Laboratory of Immunopathology Keizo Asami, Federal University of Pernambuco, Pernambuco, Brazil.; Department of Microbiology and Parasitology, Federal University of Santa Maria, Santa Maria, Brazil.; Virology Sector, Department of Preventive Veterinary Medicine, Federal University of Santa Maria, Santa Maria, Brazil.
Lopes TRR; Virology Sector, Laboratory of Immunopathology Keizo Asami, Federal University of Pernambuco, Pernambuco, Brazil.; Virology Sector, Department of Preventive Veterinary Medicine, Federal University of Santa Maria, Santa Maria, Brazil.
Weiblen R; Virology Sector, Department of Preventive Veterinary Medicine, Federal University of Santa Maria, Santa Maria, Brazil.
Flores EF; Virology Sector, Department of Preventive Veterinary Medicine, Federal University of Santa Maria, Santa Maria, Brazil.
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Źródło :
Journal of medical virology [J Med Virol] 2021 Mar; Vol. 93 (3), pp. 1253-1254. Date of Electronic Publication: 2020 Nov 01.
Typ publikacji :
Letter
MeSH Terms :
Cross Protection*
Immunity, Innate*
Social Determinants of Health*
COVID-19/*immunology
COVID-19/*prevention & control
Antibodies, Viral ; BCG Vaccine/immunology ; Host Microbial Interactions ; Humans ; Hygiene Hypothesis
Opinia redakcyjna
Tytuł :
Notch signaling at the crossroads of innate and adaptive immunity.
Autorzy :
Vanderbeck A; Immunology Graduate Group, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Veterinary Medical Scientist Training Program, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, USA.
Maillard I; Immunology Graduate Group, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Division of Hematology/Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
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Źródło :
Journal of leukocyte biology [J Leukoc Biol] 2021 Mar; Vol. 109 (3), pp. 535-548. Date of Electronic Publication: 2020 Jun 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Adaptive Immunity*
Immunity, Innate*
Signal Transduction*
Receptors, Notch/*metabolism
Animals ; Hematopoiesis ; Humans ; Lymphocytes/metabolism
Czasopismo naukowe
Tytuł :
SARS-CoV-2 membrane glycoprotein M antagonizes the MAVS-mediated innate antiviral response.
Autorzy :
Fu YZ; Key Laboratory of Special Pathogens and Biosafety, Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, 430071, Wuhan, China. .
Wang SY; Key Laboratory of Special Pathogens and Biosafety, Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, 430071, Wuhan, China.
Zheng ZQ; Key Laboratory of Special Pathogens and Biosafety, Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, 430071, Wuhan, China.; University of Chinese Academy of Sciences, 100049, Beijing, China.
Yi Huang; Key Laboratory of Special Pathogens and Biosafety, Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, 430071, Wuhan, China.
Li WW; Key Laboratory of Special Pathogens and Biosafety, Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, 430071, Wuhan, China.; University of Chinese Academy of Sciences, 100049, Beijing, China.
Xu ZS; Key Laboratory of Special Pathogens and Biosafety, Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, 430071, Wuhan, China.
Wang YY; Key Laboratory of Special Pathogens and Biosafety, Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, 430071, Wuhan, China. .; University of Chinese Academy of Sciences, 100049, Beijing, China. .
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Źródło :
Cellular & molecular immunology [Cell Mol Immunol] 2021 Mar; Vol. 18 (3), pp. 613-620. Date of Electronic Publication: 2020 Oct 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunity, Innate*
Adaptor Proteins, Signal Transducing/*immunology
COVID-19/*immunology
SARS-CoV-2/*immunology
Signal Transduction/*immunology
Viral Matrix Proteins/*immunology
HEK293 Cells ; HeLa Cells ; Humans
Czasopismo naukowe
Tytuł :
Mitochondrial reactive zones in antiviral innate immunity.
Autorzy :
Yasukawa K; Department of Biology, Faculty of Science, Kyushu University, Fukuoka 819-0395, Japan.
Koshiba T; Department of Chemistry, Faculty of Science, Fukuoka University, Fukuoka 814-0180, Japan. Electronic address: .
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Źródło :
Biochimica et biophysica acta. General subjects [Biochim Biophys Acta Gen Subj] 2021 Mar; Vol. 1865 (3), pp. 129839. Date of Electronic Publication: 2021 Jan 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Immunity, Innate*
Host-Pathogen Interactions/*immunology
Mitochondria/*immunology
RNA Virus Infections/*immunology
RNA Viruses/*immunology
Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/immunology ; Animals ; DEAD Box Protein 58/genetics ; DEAD Box Protein 58/immunology ; Gene Expression Regulation ; Host-Pathogen Interactions/genetics ; Humans ; Inflammasomes ; MicroRNAs/genetics ; MicroRNAs/immunology ; Mitochondria/genetics ; Mitochondria/virology ; Mitochondrial Membranes/immunology ; Mitochondrial Membranes/virology ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; NLR Family, Pyrin Domain-Containing 3 Protein/immunology ; RNA Virus Infections/genetics ; RNA Virus Infections/pathology ; RNA Virus Infections/virology ; RNA Viruses/genetics ; RNA Viruses/pathogenicity ; Receptors, Immunologic/genetics ; Receptors, Immunologic/immunology ; Signal Transduction
Czasopismo naukowe
Tytuł :
Contact-Free Co-Culture Model for the Study of Innate Immune Cell Activation During Respiratory Virus Infection.
Autorzy :
Lew ZZR; Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore.
Liu J; Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore.
Ong HH; Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore.
Tan VJ; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore.
Luukkainen A; Haartman Institute, Medicum, University of Helsinki.
Ong YK; Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore; Department of Otolaryngology, Head and Neck Surgery, National University Hospital, National University Health System.
Thong M; Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore; Department of Otolaryngology, Head and Neck Surgery, National University Hospital, National University Health System.
Puan KJ; Agency for Science, Technology and Research (A*STAR), Singapore Immunology Network (SIgN).
Chow VTK; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore; NUHS Infectious Diseases Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore.
Tan KS; Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore; NUHS Infectious Diseases Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore; .
Wang Y; Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore; NUHS Infectious Diseases Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore; .
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Źródło :
Journal of visualized experiments : JoVE [J Vis Exp] 2021 Feb 28 (168). Date of Electronic Publication: 2021 Feb 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Video-Audio Media
MeSH Terms :
Immunity, Innate*
Models, Biological*
Influenza A Virus, H3N2 Subtype/*immunology
Influenza, Human/*immunology
Influenza, Human/*virology
3T3 Cells ; Animals ; Cell Differentiation/drug effects ; Cells, Cultured ; Coculture Techniques ; Electric Impedance ; Epithelial Cells/drug effects ; Epithelial Cells/immunology ; Feeder Cells/cytology ; Humans ; Influenza A Virus, H3N2 Subtype/drug effects ; Killer Cells, Natural/drug effects ; Killer Cells, Natural/immunology ; Leukocytes, Mononuclear/drug effects ; Leukocytes, Mononuclear/virology ; Mice ; Mitomycin/pharmacology ; Mucin 5AC/metabolism ; Nasal Mucosa/pathology ; Tubulin/metabolism
Czasopismo naukowe
Tytuł :
Elevation in viral entry genes and innate immunity compromise underlying increased infectivity and severity of COVID-19 in cancer patients.
Autorzy :
Kwan JYY; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada.; Institute of Medical Science, University of Toronto, Toronto, ON, Canada.
Lin LT; Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Bell R; Princess Margaret Cancer Centre, Toronto, ON, Canada.
Bruce JP; Princess Margaret Cancer Centre, Toronto, ON, Canada.
Richardson C; Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada.; Department of Pediatrics, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada.
Pugh TJ; Princess Margaret Cancer Centre, Toronto, ON, Canada.; Ontario Institute for Cancer Research, Toronto, ON, Canada.
Liu FF; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada. .; Institute of Medical Science, University of Toronto, Toronto, ON, Canada. .; Princess Margaret Cancer Centre, Toronto, ON, Canada. .; Radiation Medicine Program, Princess Margaret Cancer Centre, 700 University Avenue, Toronto, ON, M5G 2M9, Canada. .; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada. .
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Źródło :
Scientific reports [Sci Rep] 2021 Feb 25; Vol. 11 (1), pp. 4533. Date of Electronic Publication: 2021 Feb 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunity, Innate*
Virus Internalization*
COVID-19/*complications
Neoplasms/*complications
SARS-CoV-2/*physiology
Adult ; Angiotensin-Converting Enzyme 2/genetics ; Angiotensin-Converting Enzyme 2/immunology ; COVID-19/genetics ; COVID-19/immunology ; Cathepsin L/genetics ; Cathepsin L/immunology ; Child ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Neoplasms/genetics ; Neoplasms/immunology ; Neoplasms/radiotherapy ; Serine Endopeptidases/genetics ; Serine Endopeptidases/immunology ; Severity of Illness Index
Czasopismo naukowe
Tytuł :
Underlying Vulnerabilities to the Cytokine Storm and Adverse COVID-19 Outcomes in the Aging Immune System.
Autorzy :
Nidadavolu LS; Biology of Healthy Aging Program, Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Walston JD; Biology of Healthy Aging Program, Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Department of Medicine, Kyung Hee University, Seoul, South Korea.
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Źródło :
The journals of gerontology. Series A, Biological sciences and medical sciences [J Gerontol A Biol Sci Med Sci] 2021 Feb 25; Vol. 76 (3), pp. e13-e18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Immunity, Innate*
Aging/*immunology
COVID-19/*immunology
COVID-19/*physiopathology
Cytokine Release Syndrome/*virology
Pneumonia, Viral/*immunology
Pneumonia, Viral/*physiopathology
Age Factors ; Aged ; Cellular Senescence/immunology ; Cytokines/immunology ; Humans ; SARS-CoV-2 ; Signal Transduction
Czasopismo naukowe
Tytuł :
Does remote ischaemic conditioning reduce inflammation? A focus on innate immunity and cytokine response.
Autorzy :
Pearce L; The Hatter Cardiovascular Institute, 67 Chenies Mews, London, WC1E 6HX, UK.
Davidson SM; The Hatter Cardiovascular Institute, 67 Chenies Mews, London, WC1E 6HX, UK.
Yellon DM; The Hatter Cardiovascular Institute, 67 Chenies Mews, London, WC1E 6HX, UK. .
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Źródło :
Basic research in cardiology [Basic Res Cardiol] 2021 Feb 24; Vol. 116 (1), pp. 12. Date of Electronic Publication: 2021 Feb 24.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Immunity, Innate*
Ischemic Preconditioning, Myocardial*
Cytokines/*physiology
Inflammation/*therapy
Myocardial Reperfusion Injury/*prevention & control
Animals ; COVID-19/complications ; Cell Survival ; Extracellular Vesicles/physiology ; Humans ; Immunity, Humoral ; Inflammation/blood ; Myocardial Reperfusion Injury/immunology
Czasopismo naukowe

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