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Wyszukujesz frazę ""Immunoglobulin Fab Fragments"" wg kryterium: Temat


Tytuł :
Comparison of F(ab') 2 and Fab antivenoms in rattlesnake envenomation: First year's post-marketing experience with F(ab') 2 in New Mexico.
Autorzy :
Mascarenas DN; University of New Mexico Health Sciences Center, Division of Pediatric Emergency Medicine, Department of Emergency Medicine, USA. Electronic address: .
Fullerton L; University of New Mexico Health Sciences Center, Department of Emergency Medicine, USA.
Smolinske SC; New Mexico Poison Center, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Warrick BJ; University of New Mexico Health Sciences Center, Department of Emergency Medicine, USA; New Mexico Poison Center, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Seifert SA; University of New Mexico Health Sciences Center, Department of Emergency Medicine, USA; New Mexico Poison Center, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
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Źródło :
Toxicon : official journal of the International Society on Toxinology [Toxicon] 2020 Oct 30; Vol. 186, pp. 42-45. Date of Electronic Publication: 2020 Aug 05.
Typ publikacji :
Journal Article
MeSH Terms :
Antivenins*
Immunoglobulin Fab Fragments*
Snake Bites*
Adolescent ; Animals ; Crotalid Venoms ; Crotalus ; Female ; Humans ; Male ; Marketing ; Mexico ; Middle Aged ; New Mexico
Czasopismo naukowe
Tytuł :
Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies.
Autorzy :
Barnes CO; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
West AP Jr; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Huey-Tubman KE; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Hoffmann MAG; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Sharaf NG; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA.
Hoffman PR; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Koranda N; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Gristick HB; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Gaebler C; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.
Muecksch F; Laboratory of Retrovirology, The Rockefeller University, New York, NY, USA.
Lorenzi JCC; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.
Finkin S; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.
Hägglöf T; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.
Hurley A; Hospital Program Direction, The Rockefeller University, New York, NY, USA.
Millard KG; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.
Weisblum Y; Laboratory of Retrovirology, The Rockefeller University, New York, NY, USA.
Schmidt F; Laboratory of Retrovirology, The Rockefeller University, New York, NY, USA.
Hatziioannou T; Laboratory of Retrovirology, The Rockefeller University, New York, NY, USA.
Bieniasz PD; Laboratory of Retrovirology, The Rockefeller University, New York, NY, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA.
Caskey M; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.
Robbiani DF; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.
Nussenzweig MC; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA. Electronic address: .
Bjorkman PJ; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA. Electronic address: .
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Źródło :
Cell [Cell] 2020 Aug 20; Vol. 182 (4), pp. 828-842.e16. Date of Electronic Publication: 2020 Jun 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Neutralizing/*chemistry
Betacoronavirus/*chemistry
Coronavirus Infections/*immunology
Immunoglobulin Fab Fragments/*chemistry
Immunoglobulin G/*chemistry
Pneumonia, Viral/*immunology
Spike Glycoprotein, Coronavirus/*chemistry
Antibodies, Neutralizing/blood ; Antibodies, Neutralizing/isolation & purification ; Antibodies, Viral/immunology ; Antibodies, Viral/isolation & purification ; Betacoronavirus/immunology ; Coronavirus Infections/blood ; Coronavirus Infections/therapy ; Cross Reactions ; Cryoelectron Microscopy ; Epitope Mapping ; Epitopes ; Humans ; Immunization, Passive ; Immunoglobulin Fab Fragments/blood ; Immunoglobulin Fab Fragments/isolation & purification ; Immunoglobulin Fab Fragments/ultrastructure ; Immunoglobulin G/blood ; Immunoglobulin G/isolation & purification ; Immunoglobulin G/ultrastructure ; Middle East Respiratory Syndrome Coronavirus/chemistry ; Middle East Respiratory Syndrome Coronavirus/immunology ; Models, Molecular ; Pandemics ; Pneumonia, Viral/blood ; SARS Virus/chemistry ; SARS Virus/immunology ; Spike Glycoprotein, Coronavirus/immunology
SCR Disease Name :
COVID-19
Czasopismo naukowe
Tytuł :
Characterization of an HLA-restricted and human cytomegalovirus-specific antibody repertoire with therapeutic potential.
Autorzy :
Bewarder M; Internal Medicine I, Saarland University Medical Center, 66421, Homburg, Germany. .; José Carreras Center, Saarland University Medical Center, Homburg, Germany. .
Held G; Internal Medicine I, Westpfalz-Klinikum Kaiserslautern, Kaiserslautern, Germany.
Thurner L; Internal Medicine I, Saarland University Medical Center, 66421, Homburg, Germany.; José Carreras Center, Saarland University Medical Center, Homburg, Germany.
Stilgenbauer S; Internal Medicine I, Saarland University Medical Center, 66421, Homburg, Germany.; José Carreras Center, Saarland University Medical Center, Homburg, Germany.
Smola S; Institute of Virology, Saarland University Medical Center, Homburg, Germany.
Preuss KD; José Carreras Center, Saarland University Medical Center, Homburg, Germany.
Carbon G; José Carreras Center, Saarland University Medical Center, Homburg, Germany.
Bette B; José Carreras Center, Saarland University Medical Center, Homburg, Germany.
Christofyllakis K; Internal Medicine I, Saarland University Medical Center, 66421, Homburg, Germany.
Bittenbring JT; Internal Medicine I, Saarland University Medical Center, 66421, Homburg, Germany.
Felbel A; Internal Medicine I, Saarland University Medical Center, 66421, Homburg, Germany.
Hasse A; Internal Medicine I, Saarland University Medical Center, 66421, Homburg, Germany.
Murawski N; Internal Medicine I, Saarland University Medical Center, 66421, Homburg, Germany.
Kaddu-Mulindwa D; Internal Medicine I, Saarland University Medical Center, 66421, Homburg, Germany.
Neumann F; José Carreras Center, Saarland University Medical Center, Homburg, Germany.
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Źródło :
Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2020 Aug; Vol. 69 (8), pp. 1535-1548. Date of Electronic Publication: 2020 Apr 16.
Typ publikacji :
Journal Article
MeSH Terms :
Cytomegalovirus/*immunology
Cytomegalovirus Infections/*prevention & control
Fibroblasts/*immunology
HLA Antigens/*immunology
Immunoglobulin Fab Fragments/*administration & dosage
Peptide Fragments/*immunology
T-Lymphocytes, Cytotoxic/*immunology
Antigens, Viral/immunology ; Cell Survival ; Cytomegalovirus Infections/immunology ; Cytomegalovirus Infections/metabolism ; Cytomegalovirus Infections/virology ; Fibroblasts/metabolism ; Fibroblasts/pathology ; Humans ; Immunoglobulin Fab Fragments/immunology ; Immunoglobulin Fab Fragments/metabolism ; Immunotoxins/administration & dosage ; Melanoma/immunology ; Melanoma/metabolism ; Melanoma/pathology ; Melanoma/prevention & control ; Receptors, Antigen, T-Cell/immunology ; Viral Proteins/immunology
Czasopismo naukowe
Tytuł :
Production of an antibody Fab fragment using 2A peptide in insect cells.
Autorzy :
Mizote Y; Department of Chemical Science and Engineering, Graduate School of Engineering, Kobe University, 1-1 Rokkodai, Nada, Kobe 657-8501, Japan.
Masumi-Koizumi K; Department of Chemical Science and Engineering, Graduate School of Engineering, Kobe University, 1-1 Rokkodai, Nada, Kobe 657-8501, Japan; Manufacturing Technology Association of Biologics, c/o Integrated Research Center of Kobe University, 7-1-49 Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan.
Katsuda T; Department of Chemical Science and Engineering, Graduate School of Engineering, Kobe University, 1-1 Rokkodai, Nada, Kobe 657-8501, Japan; Manufacturing Technology Association of Biologics, c/o Integrated Research Center of Kobe University, 7-1-49 Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan.
Yamaji H; Department of Chemical Science and Engineering, Graduate School of Engineering, Kobe University, 1-1 Rokkodai, Nada, Kobe 657-8501, Japan; Manufacturing Technology Association of Biologics, c/o Integrated Research Center of Kobe University, 7-1-49 Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan. Electronic address: .
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Źródło :
Journal of bioscience and bioengineering [J Biosci Bioeng] 2020 Aug; Vol. 130 (2), pp. 205-211. Date of Electronic Publication: 2020 Apr 11.
Typ publikacji :
Journal Article
MeSH Terms :
Immunoglobulin Fab Fragments/*biosynthesis
Recombinant Proteins/*biosynthesis
Amino Acid Sequence ; Animals ; Blotting, Western ; Cell Line ; Enzyme-Linked Immunosorbent Assay ; Genetic Vectors/genetics ; Humans ; Immunoglobulin Fab Fragments/genetics ; Insecta/cytology ; Peptides/metabolism ; Plasmids/genetics ; Recombinant Proteins/genetics ; Teschovirus/genetics ; Transfection
Czasopismo naukowe
Tytuł :
Targeted inhibition of activated protein C by a non-active-site inhibitory antibody to treat hemophilia.
Autorzy :
Zhao XY; US Innovation Center, Bayer, 455 Mission Bay Blvd. South, San Francisco, CA, 94158, USA. .
Wilmen A; Biological Research, Bayer AG, 42113, Wuppertal, Germany.
Wang D; Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, 100084, China.
Wang X; Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, 100084, China.
Bauzon M; US Innovation Center, Bayer, 455 Mission Bay Blvd. South, San Francisco, CA, 94158, USA.
Kim JY; US Innovation Center, Bayer, 455 Mission Bay Blvd. South, San Francisco, CA, 94158, USA.
Linden L; Biological Research, Bayer AG, 42113, Wuppertal, Germany.
Li L; Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, 100084, China.
Egner U; Structural Biology, Bayer AG, 13342, Berlin, Germany.
Marquardt T; Structural Biology, Bayer AG, 13342, Berlin, Germany.
Moosmayer D; Structural Biology, Bayer AG, 13342, Berlin, Germany.
Tebbe J; Biological Research, Bayer AG, 42113, Wuppertal, Germany.
Glück JM; Biological Research, Bayer AG, 42113, Wuppertal, Germany.
Ellinger P; Biological Research, Bayer AG, 42113, Wuppertal, Germany.
McLean K; US Innovation Center, Bayer, 455 Mission Bay Blvd. South, San Francisco, CA, 94158, USA.
Yuan S; US Innovation Center, Bayer, 455 Mission Bay Blvd. South, San Francisco, CA, 94158, USA.
Yegneswaran S; US Innovation Center, Bayer, 455 Mission Bay Blvd. South, San Francisco, CA, 94158, USA.
Jiang X; US Innovation Center, Bayer, 455 Mission Bay Blvd. South, San Francisco, CA, 94158, USA.
Evans V; US Innovation Center, Bayer, 455 Mission Bay Blvd. South, San Francisco, CA, 94158, USA.
Gu JM; US Innovation Center, Bayer, 455 Mission Bay Blvd. South, San Francisco, CA, 94158, USA.
Schneider D; US Innovation Center, Bayer, 455 Mission Bay Blvd. South, San Francisco, CA, 94158, USA.
Zhu Y; US Innovation Center, Bayer, 455 Mission Bay Blvd. South, San Francisco, CA, 94158, USA.
Xu Y; US Innovation Center, Bayer, 455 Mission Bay Blvd. South, San Francisco, CA, 94158, USA.
Mallari C; US Innovation Center, Bayer, 455 Mission Bay Blvd. South, San Francisco, CA, 94158, USA.
Hesslein A; Biological Development, Bayer, Berkeley, CA, 94710, USA.
Wang Y; US Innovation Center, Bayer, 455 Mission Bay Blvd. South, San Francisco, CA, 94158, USA.
Schmidt N; US Innovation Center, Bayer, 455 Mission Bay Blvd. South, San Francisco, CA, 94158, USA.
Gutberlet K; Pathology/Toxicology, Bayer AG, 42096, Wuppertal, Germany.
Ruehl-Fehlert C; Pathology/Toxicology, Bayer AG, 42096, Wuppertal, Germany.
Freyberger A; Pathology/Toxicology, Bayer AG, 42096, Wuppertal, Germany.
Hermiston T; US Innovation Center, Bayer, 455 Mission Bay Blvd. South, San Francisco, CA, 94158, USA.
Patel C; US Innovation Center, Bayer, 455 Mission Bay Blvd. South, San Francisco, CA, 94158, USA.
Sim D; US Innovation Center, Bayer, 455 Mission Bay Blvd. South, San Francisco, CA, 94158, USA.
Mosnier LO; The Scripps Research Institute, 10550 North Torrey Pines Rd., La Jolla, CA, 92037, USA. .
Laux V; TRG-Cardiology/Hematology, Bayer AG, Aprather Weg 18a, 42113, Wuppertal, Germany. .
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Źródło :
Nature communications [Nat Commun] 2020 Jun 12; Vol. 11 (1), pp. 2992. Date of Electronic Publication: 2020 Jun 12.
Typ publikacji :
Journal Article
MeSH Terms :
Antibodies, Monoclonal/*pharmacology
Hemophilia A/*prevention & control
Immunoglobulin Fab Fragments/*immunology
Protein C/*antagonists & inhibitors
Protein C Inhibitor/*pharmacology
Animals ; Antibodies, Monoclonal/classification ; Antibodies, Monoclonal/immunology ; Bleeding Time ; Cell Membrane Permeability/drug effects ; Cells, Cultured ; Crystallography, X-Ray ; Hemophilia A/blood ; Hemorrhage/prevention & control ; Human Umbilical Vein Endothelial Cells/drug effects ; Human Umbilical Vein Endothelial Cells/metabolism ; Human Umbilical Vein Endothelial Cells/physiology ; Humans ; Immunoglobulin Fab Fragments/metabolism ; Macaca fascicularis ; Male ; Protein C/chemistry ; Protein C/immunology ; Protein C/metabolism ; Protein C Inhibitor/blood ; Protein C Inhibitor/pharmacokinetics
Czasopismo naukowe
Tytuł :
Structural basis of serum albumin recognition by SL335, an antibody Fab extending the serum half-life of protein therapeutics.
Autorzy :
Cho SY; Division of Biomedical Convergence, College of Biomedical Science, Kangwon National University, Chuncheon, 24341, Republic of Korea.
Han J; AprilBio Co., Ltd, Kangwon National University, Rm. B602, Biomedical Science Building, Chuncheon, 24341, Republic of Korea.
Cha SH; Division of Biomedical Convergence, College of Biomedical Science, Kangwon National University, Chuncheon, 24341, Republic of Korea; AprilBio Co., Ltd, Kangwon National University, Rm. B602, Biomedical Science Building, Chuncheon, 24341, Republic of Korea. Electronic address: .
Yoon SI; Division of Biomedical Convergence, College of Biomedical Science, Kangwon National University, Chuncheon, 24341, Republic of Korea. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Jun 11; Vol. 526 (4), pp. 941-946. Date of Electronic Publication: 2020 Apr 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies/*immunology
Immunoglobulin Fab Fragments/*immunology
Recombinant Proteins/*blood
Recombinant Proteins/*therapeutic use
Serum Albumin, Human/*chemistry
Serum Albumin, Human/*immunology
Antibodies/chemistry ; Cross Reactions ; Half-Life ; Histocompatibility Antigens Class I/metabolism ; Humans ; Immunoglobulin Fab Fragments/chemistry ; Models, Molecular ; Protein Binding ; Receptors, Fc/metabolism
Czasopismo naukowe
Tytuł :
An easy and simple separation method for Fc and Fab fragments from chicken immunoglobulin Y (IgY).
Autorzy :
Zhou X; College of Food Science and Technology, Huazhong Agricultural University, National Research and Development Center for Egg Processing, Wuhan, Hubei 430070, PR China.
Wang Y; College of Food Science and Technology, Huazhong Agricultural University, National Research and Development Center for Egg Processing, Wuhan, Hubei 430070, PR China.
Ahn DU; Department of Animal Science, Iowa State University, Ames, IA 50011, USA.
Cai Z; College of Food Science and Technology, Huazhong Agricultural University, National Research and Development Center for Egg Processing, Wuhan, Hubei 430070, PR China. Electronic address: .
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Źródło :
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences [J Chromatogr B Analyt Technol Biomed Life Sci] 2020 Mar 15; Vol. 1141, pp. 122011. Date of Electronic Publication: 2020 Jan 31.
Typ publikacji :
Journal Article
MeSH Terms :
Immunoglobulin Fab Fragments/*analysis
Immunoglobulin Fab Fragments/*isolation & purification
Immunoglobulin Fc Fragments/*analysis
Immunoglobulin Fc Fragments/*isolation & purification
Immunoglobulins/*metabolism
Ammonium Sulfate/chemistry ; Animals ; Blotting, Western ; Chickens ; Chromatography, Ion Exchange ; Immunoglobulin Fab Fragments/chemistry ; Immunoglobulin Fab Fragments/metabolism ; Immunoglobulin Fc Fragments/chemistry ; Immunoglobulin Fc Fragments/metabolism ; Immunoglobulins/chemistry ; Papain/metabolism
Czasopismo naukowe
Tytuł :
Biophysical characterization and single-chain Fv construction of a neutralizing antibody to measles virus.
Autorzy :
Tadokoro T; Faculty of Pharmaceutical Science, Hokkaido University, Sapporo, Japan.
Jahan ML; Faculty of Pharmaceutical Science, Hokkaido University, Sapporo, Japan.
Ito Y; Faculty of Pharmaceutical Science, Hokkaido University, Sapporo, Japan.
Tahara M; Department of Virology 3, National Institute of Infectious Diseases, Tokyo, Japan.
Chen S; Faculty of Pharmaceutical Science, Hokkaido University, Sapporo, Japan.
Imai A; Faculty of Pharmaceutical Science, Hokkaido University, Sapporo, Japan.
Sugimura N; Faculty of Pharmaceutical Science, Hokkaido University, Sapporo, Japan.
Yoshida K; Faculty of Pharmaceutical Science, Hokkaido University, Sapporo, Japan.
Saito M; Faculty of Pharmaceutical Science, Hokkaido University, Sapporo, Japan.
Ose T; Faculty of Pharmaceutical Science, Hokkaido University, Sapporo, Japan.
Hashiguchi T; Department of Virology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Takeda M; Department of Virology 3, National Institute of Infectious Diseases, Tokyo, Japan.
Fukuhara H; Faculty of Pharmaceutical Science, Hokkaido University, Sapporo, Japan.
Maenaka K; Faculty of Pharmaceutical Science, Hokkaido University, Sapporo, Japan.
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Źródło :
The FEBS journal [FEBS J] 2020 Jan; Vol. 287 (1), pp. 145-159. Date of Electronic Publication: 2019 Jul 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Neutralizing/*immunology
Antibodies, Viral/*immunology
Immunoglobulin Fab Fragments/*immunology
Measles/*immunology
Measles virus/*immunology
Single-Chain Antibodies/*immunology
Viral Proteins/*immunology
Antibodies, Neutralizing/biosynthesis ; Antibodies, Neutralizing/genetics ; Antibodies, Viral/biosynthesis ; Antibodies, Viral/genetics ; Epitopes/immunology ; HEK293 Cells ; Humans ; Immunoglobulin Fab Fragments/biosynthesis ; Immunoglobulin Fab Fragments/genetics ; Measles/virology ; Nectins/antagonists & inhibitors ; Nectins/immunology ; Nectins/metabolism ; Protein Binding ; Signaling Lymphocytic Activation Molecule Family Member 1/antagonists & inhibitors ; Signaling Lymphocytic Activation Molecule Family Member 1/immunology ; Signaling Lymphocytic Activation Molecule Family Member 1/metabolism ; Single-Chain Antibodies/biosynthesis ; Single-Chain Antibodies/genetics ; Virus Internalization
Czasopismo naukowe
Tytuł :
An engineered ultra-high affinity Fab-Protein G pair enables a modular antibody platform with multifunctional capability.
Autorzy :
Slezak T; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois.
Bailey LJ; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois.
Jaskolowski M; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois.; Institute for Biophysical Dynamics, The University of Chicago, Chicago, Illinois.
Nahotko DA; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois.
Filippova EV; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois.
Davydova EK; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois.
Kossiakoff AA; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois.
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Źródło :
Protein science : a publication of the Protein Society [Protein Sci] 2020 Jan; Vol. 29 (1), pp. 141-156. Date of Electronic Publication: 2019 Nov 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Immunoglobulin Fab Fragments/*genetics
Nerve Tissue Proteins/*genetics
Protein Engineering/*methods
Cell Line ; Humans ; Immunoglobulin Fab Fragments/chemistry ; Immunoglobulin Fab Fragments/metabolism ; Models, Molecular ; Nerve Tissue Proteins/chemistry ; Nerve Tissue Proteins/metabolism ; Protein Conformation ; Protein Domains ; Recombinant Proteins/metabolism
Czasopismo naukowe
Tytuł :
Engineering the Fab fragment of the anti-IgE omalizumab to prevent Fab crystallization and permit IgE-Fc complex crystallization.
Autorzy :
Mitropoulou AN; Randall Centre for Cell and Molecular Biophysics, King's College London, New Hunt's House, London SE1 1UL, UK.
Ceska T; UCB Celltech, 208 Bath Road, Slough SL1 3WE, UK.
Heads JT; UCB Celltech, 208 Bath Road, Slough SL1 3WE, UK.
Beavil AJ; Randall Centre for Cell and Molecular Biophysics, King's College London, New Hunt's House, London SE1 1UL, UK.
Henry AJ; UCB Celltech, 208 Bath Road, Slough SL1 3WE, UK.
McDonnell JM; Randall Centre for Cell and Molecular Biophysics, King's College London, New Hunt's House, London SE1 1UL, UK.
Sutton BJ; Randall Centre for Cell and Molecular Biophysics, King's College London, New Hunt's House, London SE1 1UL, UK.
Davies AM; Randall Centre for Cell and Molecular Biophysics, King's College London, New Hunt's House, London SE1 1UL, UK.
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Źródło :
Acta crystallographica. Section F, Structural biology communications [Acta Crystallogr F Struct Biol Commun] 2020 Mar 01; Vol. 76 (Pt 3), pp. 116-129. Date of Electronic Publication: 2020 Mar 02.
Typ publikacji :
Journal Article
MeSH Terms :
Antibodies, Anti-Idiotypic/*metabolism
Crystallization/*methods
Immunoglobulin E/*metabolism
Immunoglobulin Fab Fragments/*metabolism
Immunoglobulin Fc Fragments/*metabolism
Omalizumab/*metabolism
Antibodies, Anti-Idiotypic/chemistry ; Crystallography, X-Ray/methods ; Humans ; Immunoglobulin E/chemistry ; Immunoglobulin Fab Fragments/chemistry ; Immunoglobulin Fc Fragments/chemistry ; Omalizumab/pharmacology ; Protein Structure, Secondary ; Protein Structure, Tertiary
Czasopismo naukowe
Tytuł :
High-Throughput Generation of In Silico Derived Synthetic Antibodies via One-step Enzymatic DNA Assembly of Fragments.
Autorzy :
Gallo E; Department of Molecular Genetics, Charles Best Institute, University of Toronto, 112 College Street, 112 College Street, Room 70, Toronto, ON, M5G 1L6, Canada. .
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Źródło :
Molecular biotechnology [Mol Biotechnol] 2020 Feb; Vol. 62 (2), pp. 142-150.
Typ publikacji :
Journal Article
MeSH Terms :
Antibodies/*genetics
Immunoglobulin Fab Fragments/*genetics
Single-Domain Antibodies/*genetics
Antibodies/chemistry ; Antibodies/metabolism ; Cell Surface Display Techniques/methods ; Computer Simulation ; DNA Ligases/metabolism ; DNA-Directed DNA Polymerase/metabolism ; Exonucleases/metabolism ; Gene Expression ; High-Throughput Nucleotide Sequencing ; High-Throughput Screening Assays ; Immunoglobulin Fab Fragments/metabolism ; Plasmids/genetics ; Single-Domain Antibodies/metabolism
Czasopismo naukowe
Tytuł :
Development of a hyperimmune equine serum therapy for COVID-19 in Argentina.
Autorzy :
Zylberman V; Inmunova S.A., San Martín, Provincia de Buenos Aires, Argentina.; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina.
Sanguineti S; Inmunova S.A., San Martín, Provincia de Buenos Aires, Argentina.
Pontoriero AV; Servicio Virosis Respiratorias INEI-ANLIS Malbrán, Laboratorio Nacional de Referencia de Enfermedades Respiratorias Virales, Centro Nacional de Influenza de OMS, Buenos Aires, Argentina.
Higa SV; Instituto Biológico Argentino S.A.I.C., Buenos Aires, Argentina.
Cerutti ML; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina.; CRIP -Centro de Rediseño e Ingeniería de Proteínas UNSAM, Campus Miguelete, San Martín, Provincia de Buenos Aires, Argentina.
Morrone Seijo SM; Inmunova S.A., San Martín, Provincia de Buenos Aires, Argentina.
Pardo R; Inmunova S.A., San Martín, Provincia de Buenos Aires, Argentina.
Muñoz L; Inmunova S.A., San Martín, Provincia de Buenos Aires, Argentina.
Acuña Intrieri ME; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina.; CRIP -Centro de Rediseño e Ingeniería de Proteínas UNSAM, Campus Miguelete, San Martín, Provincia de Buenos Aires, Argentina.
Alzogaray VA; Laboratorio de Inmunología y Microbiología Molecular, Fundación Instituto Leloir, IIBBA-CONICET, Buenos Aires, Argentina.
Avaro MM; Servicio Virosis Respiratorias INEI-ANLIS Malbrán, Laboratorio Nacional de Referencia de Enfermedades Respiratorias Virales, Centro Nacional de Influenza de OMS, Buenos Aires, Argentina.
Benedetti E; Servicio Virosis Respiratorias INEI-ANLIS Malbrán, Laboratorio Nacional de Referencia de Enfermedades Respiratorias Virales, Centro Nacional de Influenza de OMS, Buenos Aires, Argentina.
Berguer PM; Laboratorio de Inmunología y Microbiología Molecular, Fundación Instituto Leloir, IIBBA-CONICET, Buenos Aires, Argentina.
Bocanera L; mAbxience, Munro, Provincia de Buenos Aires, Argentina.
Bukata L; Inmunova S.A., San Martín, Provincia de Buenos Aires, Argentina.
Bustelo MS; Inmunova S.A., San Martín, Provincia de Buenos Aires, Argentina.
Campos AM; Servicio Virosis Respiratorias INEI-ANLIS Malbrán, Laboratorio Nacional de Referencia de Enfermedades Respiratorias Virales, Centro Nacional de Influenza de OMS, Buenos Aires, Argentina.
Colonna M; Inmunova S.A., San Martín, Provincia de Buenos Aires, Argentina.
Correa E; mAbxience, Munro, Provincia de Buenos Aires, Argentina.
Cragnaz L; mAbxience, Munro, Provincia de Buenos Aires, Argentina.
Dattero ME; Servicio Virosis Respiratorias INEI-ANLIS Malbrán, Laboratorio Nacional de Referencia de Enfermedades Respiratorias Virales, Centro Nacional de Influenza de OMS, Buenos Aires, Argentina.
Dellafiore M; mAbxience, Munro, Provincia de Buenos Aires, Argentina.
Foscaldi S; Laboratorio de Inmunología y Microbiología Molecular, Fundación Instituto Leloir, IIBBA-CONICET, Buenos Aires, Argentina.
González JV; Inmunova S.A., San Martín, Provincia de Buenos Aires, Argentina.
Guerra LL; mAbxience, Munro, Provincia de Buenos Aires, Argentina.
Klinke S; Laboratorio de Inmunología y Microbiología Molecular, Fundación Instituto Leloir, IIBBA-CONICET, Buenos Aires, Argentina.
Labanda MS; Laboratorio de Inmunología y Microbiología Molecular, Fundación Instituto Leloir, IIBBA-CONICET, Buenos Aires, Argentina.
Lauché C; Inmunova S.A., San Martín, Provincia de Buenos Aires, Argentina.
López JC; Instituto Biológico Argentino S.A.I.C., Buenos Aires, Argentina.
Martínez AM; Instituto Biológico Argentino S.A.I.C., Buenos Aires, Argentina.
Otero LH; Laboratorio de Inmunología y Microbiología Molecular, Fundación Instituto Leloir, IIBBA-CONICET, Buenos Aires, Argentina.
Peyric EH; Instituto Biológico Argentino S.A.I.C., Buenos Aires, Argentina.
Ponziani PF; Instituto Biológico Argentino S.A.I.C., Buenos Aires, Argentina.
Ramondino R; Inmunova S.A., San Martín, Provincia de Buenos Aires, Argentina.
Rinaldi J; Laboratorio de Inmunología y Microbiología Molecular, Fundación Instituto Leloir, IIBBA-CONICET, Buenos Aires, Argentina.
Rodríguez S; mAbxience, Munro, Provincia de Buenos Aires, Argentina.
Russo JE; Instituto Biológico Argentino S.A.I.C., Buenos Aires, Argentina.
Russo ML; Servicio Virosis Respiratorias INEI-ANLIS Malbrán, Laboratorio Nacional de Referencia de Enfermedades Respiratorias Virales, Centro Nacional de Influenza de OMS, Buenos Aires, Argentina.
Saavedra SL; Instituto Biológico Argentino S.A.I.C., Buenos Aires, Argentina.
Seigelchifer M; mAbxience, Munro, Provincia de Buenos Aires, Argentina.
Sosa S; Laboratorio de Inmunología y Microbiología Molecular, Fundación Instituto Leloir, IIBBA-CONICET, Buenos Aires, Argentina.
Vilariño C; >CRIP -Centro de Rediseño e Ingeniería de Proteínas UNSAM, Campus Miguelete, San Martín, Provincia de Buenos Aires, Argentina.
López Biscayart P; Instituto Biológico Argentino S.A.I.C., Buenos Aires, Argentina.
Corley E; mAbxience, Munro, Provincia de Buenos Aires, Argentina.
Spatz L; Inmunova S.A., San Martín, Provincia de Buenos Aires, Argentina.
Baumeister EG; Servicio Virosis Respiratorias INEI-ANLIS Malbrán, Laboratorio Nacional de Referencia de Enfermedades Respiratorias Virales, Centro Nacional de Influenza de OMS, Buenos Aires, Argentina.
Goldbaum FA; Inmunova S.A., San Martín, Provincia de Buenos Aires, Argentina.; CRIP -Centro de Rediseño e Ingeniería de Proteínas UNSAM, Campus Miguelete, San Martín, Provincia de Buenos Aires, Argentina.; Laboratorio de Inmunología y Microbiología Molecular, Fundación Instituto Leloir, IIBBA-CONICET, Buenos Aires, Argentina.
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Transliterated Title :
Desarrollo de un suero equino hiperinmune para el tratamiento de COVID-19 en Argentina.
Źródło :
Medicina [Medicina (B Aires)] 2020; Vol. 80 Suppl 3, pp. 1-6.
Typ publikacji :
Journal Article
MeSH Terms :
Antibodies, Viral*/chemistry
Antibodies, Viral*/immunology
Antibodies, Viral*/isolation & purification
Pandemics*
Pneumonia, Viral*
Spike Glycoprotein, Coronavirus*
Coronavirus Infections/*therapy
Immune Sera/*immunology
Immunoglobulin Fab Fragments/*isolation & purification
Immunoglobulin G/*isolation & purification
Animals ; Argentina ; Betacoronavirus ; Horses ; Humans ; Immunization, Passive ; Immunoglobulin Fab Fragments/chemistry ; Immunoglobulin G/chemistry ; Neutralization Tests
SCR Disease Name :
COVID-19
Czasopismo naukowe
Tytuł :
Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient.
Autorzy :
Zhou D; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford, UK.
Duyvesteyn HME; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford, UK.
Chen CP; Department of Infectious Diseases, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, and National Yang-Ming University, Taipei, Taiwan.
Huang CG; Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan, Taiwan.; Department of Laboratory Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Chen TH; Genomics Research Center, Academia Sinica, Taipei, Taiwan.
Shih SR; Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan, Taiwan.; Department of Laboratory Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Lin YC; Department of Infectious Diseases, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, and Taipei Medical University, Taipei, Taiwan.
Cheng CY; Department of Infectious Diseases, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, and National Yang-Ming University, Taipei, Taiwan.
Cheng SH; Department of Infectious Diseases, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, and Taipei Medical University, Taipei, Taiwan.
Huang YC; Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Lin TY; Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Ma C; Genomics Research Center, Academia Sinica, Taipei, Taiwan.
Huo J; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford, UK.; The Rosalind Franklin Institute, Harwell Campus, Didcot, UK.; Protein Production UK, Research Complex at Harwell, Harwell Science & Innovation Campus, Didcot, UK.
Carrique L; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford, UK.
Malinauskas T; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford, UK.
Ruza RR; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford, UK.
Shah PNM; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford, UK.
Tan TK; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Rijal P; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.; Centre for Translational Immunology, Chinese Academy of Medical Sciences Oxford Institute, University of Oxford, Oxford, UK.
Donat RF; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Godwin K; National Infection Service, Public Health England, Porton Down, Salisbury, UK.
Buttigieg KR; National Infection Service, Public Health England, Porton Down, Salisbury, UK.
Tree JA; National Infection Service, Public Health England, Porton Down, Salisbury, UK.
Radecke J; Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK.
Paterson NG; Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK.
Supasa P; Nuffield Department of Medicine, Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Mongkolsapaya J; Nuffield Department of Medicine, Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Dengue Hemorrhagic Fever Research Unit, Office for Research and Development, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Screaton GR; Nuffield Department of Medicine, Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Carroll MW; National Infection Service, Public Health England, Porton Down, Salisbury, UK.; Nuffield Department of Medicine, Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Gilbert-Jaramillo J; William Dunn School of Pathology, University of Oxford, Oxford, UK.
Knight ML; William Dunn School of Pathology, University of Oxford, Oxford, UK.
James W; William Dunn School of Pathology, University of Oxford, Oxford, UK.
Owens RJ; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford, UK.; The Rosalind Franklin Institute, Harwell Campus, Didcot, UK.; Protein Production UK, Research Complex at Harwell, Harwell Science & Innovation Campus, Didcot, UK.
Naismith JH; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford, UK.; The Rosalind Franklin Institute, Harwell Campus, Didcot, UK.; Protein Production UK, Research Complex at Harwell, Harwell Science & Innovation Campus, Didcot, UK.
Townsend AR; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.; Centre for Translational Immunology, Chinese Academy of Medical Sciences Oxford Institute, University of Oxford, Oxford, UK.
Fry EE; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford, UK.
Zhao Y; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford, UK.
Ren J; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford, UK.
Stuart DI; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford, UK. .; Centre for Translational Immunology, Chinese Academy of Medical Sciences Oxford Institute, University of Oxford, Oxford, UK. .; Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK. .
Huang KA; Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan, Taiwan. .; Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan. .
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Źródło :
Nature structural & molecular biology [Nat Struct Mol Biol] 2020 Oct; Vol. 27 (10), pp. 950-958. Date of Electronic Publication: 2020 Jul 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Viral/*chemistry
Betacoronavirus/*chemistry
Coronavirus Infections/*immunology
Pneumonia, Viral/*immunology
Spike Glycoprotein, Coronavirus/*chemistry
Adult ; Animals ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; Antibodies, Viral/metabolism ; Betacoronavirus/immunology ; Betacoronavirus/metabolism ; Binding Sites ; Chlorocebus aethiops ; Cross Reactions ; Cryoelectron Microscopy ; Crystallography, X-Ray ; Epitopes ; Humans ; Immunoglobulin Fab Fragments/chemistry ; Immunoglobulin Fab Fragments/metabolism ; Male ; Pandemics ; Peptidyl-Dipeptidase A/metabolism ; Protein Conformation ; Protein Domains ; Spike Glycoprotein, Coronavirus/immunology ; Spike Glycoprotein, Coronavirus/metabolism ; Vero Cells
SCR Disease Name :
COVID-19
Czasopismo naukowe
Tytuł :
[The hinge region of therapeutic antibodies: major importance of a short sequence].
Autorzy :
Deveuve Q; Université de Tours, EA7501 GICC (Groupe Innovation et Ciblage Cellulaire), équipe FRAME (Fc Récepteurs, Anticorps et MicroEnvironnement), 37032 Tours, France.
Gouilleux-Gruart V; Université de Tours, EA7501 GICC (Groupe Innovation et Ciblage Cellulaire), équipe FRAME (Fc Récepteurs, Anticorps et MicroEnvironnement), 37032 Tours, France - Service d'immunologie, CHRU de Tours, 37044 Tours, France.
Thibault G; Université de Tours, EA7501 GICC (Groupe Innovation et Ciblage Cellulaire), équipe FRAME (Fc Récepteurs, Anticorps et MicroEnvironnement), 37032 Tours, France - Service d'immunologie, CHRU de Tours, 37044 Tours, France.
Lajoie L; Université de Tours, EA7501 GICC (Groupe Innovation et Ciblage Cellulaire), équipe FRAME (Fc Récepteurs, Anticorps et MicroEnvironnement), 37032 Tours, France.
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Transliterated Title :
La région charnière des anticorps thérapeutiques - L’importance capitale d’une courte séquence.
Źródło :
Medecine sciences : M/S [Med Sci (Paris)] 2019 Dec; Vol. 35 (12), pp. 1098-1105. Date of Electronic Publication: 2020 Jan 06.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antibodies, Monoclonal/*chemistry
Immunoglobulin Fab Fragments/*chemistry
Immunoglobulin Fab Fragments/*therapeutic use
Immunoglobulin Fc Fragments/*chemistry
Amino Acid Sequence ; Antibodies, Monoclonal/metabolism ; Antibodies, Monoclonal/therapeutic use ; Binding Sites ; Drug Development/methods ; Drug Development/trends ; Humans ; Immunoglobulin Fab Fragments/metabolism ; Immunoglobulin Fc Fragments/metabolism ; Immunoglobulin Fc Fragments/therapeutic use ; Immunoglobulin G/chemistry ; Immunoglobulin G/metabolism ; Immunoglobulin G/therapeutic use ; Peptide Hydrolases/metabolism ; Protein Engineering/methods ; Protein Engineering/trends ; Proteolysis
Czasopismo naukowe
Tytuł :
Dynamic Aspects of the Immunoglobulin Structure.
Autorzy :
Nezlin R; Department of Immunology, The Weizmann Institute of Science , Rehovot , Israel.
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Źródło :
Immunological investigations [Immunol Invest] 2019 Nov; Vol. 48 (8), pp. 771-780. Date of Electronic Publication: 2019 May 02.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Protein Domains*
Protein Multimerization*
Immunoglobulin Fab Fragments/*chemistry
Immunoglobulin Fc Fragments/*chemistry
Immunoglobulin G/*chemistry
Antigens/chemistry ; Antigens/immunology ; Antigens/metabolism ; Humans ; Immunoglobulin Fab Fragments/immunology ; Immunoglobulin Fab Fragments/metabolism ; Immunoglobulin Fc Fragments/immunology ; Immunoglobulin Fc Fragments/metabolism ; Immunoglobulin G/immunology ; Immunoglobulin G/metabolism ; Models, Molecular ; Protein Binding ; Rotation
Czasopismo naukowe
Tytuł :
Biochemical and Structural Insights into Carbonic Anhydrase XII/Fab6A10 Complex.
Autorzy :
Alterio V; Istituto di Biostrutture e Bioimmagini, CNR, Via Mezzocannone 16, Naples, 80134, Italy.
Kellner M; Department of Gene Vectors, Helmholtz Center for Environmental Health, Munich, Germany.
Esposito D; Istituto di Biostrutture e Bioimmagini, CNR, Via Mezzocannone 16, Naples, 80134, Italy.
Liesche-Starnecker F; School of Medicine, Institute of Pathology, Department of Neuropathology, Technical University Munich, Munich, Germany.
Bua S; Dipartimento Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche, UniversitàDegli Studi di Firenze, Via U. Schiff 6, Sesto Fiorentino, Florence, 50019, Italy.
Supuran CT; Dipartimento Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche, UniversitàDegli Studi di Firenze, Via U. Schiff 6, Sesto Fiorentino, Florence, 50019, Italy.
Monti SM; Istituto di Biostrutture e Bioimmagini, CNR, Via Mezzocannone 16, Naples, 80134, Italy. Electronic address: .
Zeidler R; Department of Gene Vectors, Helmholtz Center for Environmental Health, Munich, Germany; Department of Otorhinolaryngology, Klinikum der Universität München, Munich, Germany. Electronic address: .
De Simone G; Istituto di Biostrutture e Bioimmagini, CNR, Via Mezzocannone 16, Naples, 80134, Italy. Electronic address: .
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Źródło :
Journal of molecular biology [J Mol Biol] 2019 Dec 06; Vol. 431 (24), pp. 4910-4921. Date of Electronic Publication: 2019 Nov 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Monoclonal/*chemistry
Antigen-Antibody Complex/*chemistry
Carbonic Anhydrases/*chemistry
Immunoglobulin Fab Fragments/*chemistry
Antibody Affinity ; Binding Sites ; Catalysis ; Humans ; Immunoglobulin Fab Fragments/pharmacology ; Immunohistochemistry ; Models, Molecular ; Protein Binding ; Protein Conformation ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Presumed Copperhead Snakebite and Antivenom Administration in the Third Trimester.
Autorzy :
Yano J; Family Medicine, WakeMed Health & Hospitals, Raleigh, NC. Electronic address: .
Zerden M; Family Medicine, WakeMed Health & Hospitals, Raleigh, NC.
German B; Emergency Medicine, WakeMed Health & Hospitals, Raleigh, NC.
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Źródło :
Wilderness & environmental medicine [Wilderness Environ Med] 2019 Dec; Vol. 30 (4), pp. 446-449. Date of Electronic Publication: 2019 Nov 05.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Agkistrodon*
Antivenins/*therapeutic use
Immunoglobulin Fab Fragments/*therapeutic use
Snake Bites/*therapy
Adult ; Animals ; Antivenins/administration & dosage ; Crotalid Venoms/poisoning ; Female ; Humans ; Immunoglobulin Fab Fragments/administration & dosage ; Pregnancy ; Pregnancy Outcome
Czasopismo naukowe
Tytuł :
Infliximab-Tumor Necrosis Factor Complexes Elicit Formation of Anti-Drug Antibodies.
Autorzy :
Bar-Yoseph H; Department of Gastroenterology, Rambam Health Care Campus, Haifa, Israel; Bruce Rappaport School of Medicine, Technion Israel Institute of Technology, Haifa, Israel.
Pressman S; Department of Gastroenterology, Rambam Health Care Campus, Haifa, Israel.
Blatt A; Department of Gastroenterology, Rambam Health Care Campus, Haifa, Israel.
Gerassy Vainberg S; Department of Gastroenterology, Rambam Health Care Campus, Haifa, Israel.
Maimon N; Department of Gastroenterology, Rambam Health Care Campus, Haifa, Israel; Bruce Rappaport School of Medicine, Technion Israel Institute of Technology, Haifa, Israel.
Starosvetsky E; Bruce Rappaport School of Medicine, Technion Israel Institute of Technology, Haifa, Israel.
Ungar B; Department of Gastroenterology, Chaim Sheba Medical Center, Ramat-Gan, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Ben-Horin S; Department of Gastroenterology, Chaim Sheba Medical Center, Ramat-Gan, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Shen-Orr SS; Bruce Rappaport School of Medicine, Technion Israel Institute of Technology, Haifa, Israel.
Chowers Y; Department of Gastroenterology, Rambam Health Care Campus, Haifa, Israel; Bruce Rappaport School of Medicine, Technion Israel Institute of Technology, Haifa, Israel; Clinical Research Institute, Rambam Health Care Campus, Haifa, Israel. Electronic address: .
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Corporate Authors :
Israeli IBD Research Nucleus
Źródło :
Gastroenterology [Gastroenterology] 2019 Nov; Vol. 157 (5), pp. 1338-1351.e8. Date of Electronic Publication: 2019 Aug 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies/*blood
Immunoglobulin Fab Fragments/*immunology
Inflammatory Bowel Diseases/*immunology
Infliximab/*immunology
Intestines/*immunology
Tumor Necrosis Factor Inhibitors/*immunology
Tumor Necrosis Factor-alpha/*immunology
Animals ; Case-Control Studies ; Endocytosis ; Female ; Humans ; Immunity, Innate ; Immunoglobulin Fab Fragments/administration & dosage ; Inflammatory Bowel Diseases/blood ; Inflammatory Bowel Diseases/drug therapy ; Infliximab/administration & dosage ; Injections, Intravenous ; Interleukin-1beta/immunology ; Interleukin-1beta/metabolism ; Leukocytes, Mononuclear/immunology ; Leukocytes, Mononuclear/metabolism ; Macrophages/immunology ; Macrophages/metabolism ; Mice, Inbred C57BL ; THP-1 Cells ; Tumor Necrosis Factor Inhibitors/administration & dosage ; Tumor Necrosis Factor-alpha/administration & dosage ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Tytuł :
What's eating you? dusky pigmy rattlesnake envenomation and management.
Autorzy :
Sequeira MJ; Department of Dermatology and Cutaneous Surgery, University of Miami, Florida, USA.
Sequeira AJ; Brevard Skin and Cancer Center, Rockledge, Florida, USA.
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Źródło :
Cutis [Cutis] 2019 Nov; Vol. 104 (5), pp. 284-287.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Immunoglobulin Fab Fragments*
Antivenins/*therapeutic use
Crotalid Venoms/*antagonists & inhibitors
Snake Bites/*diagnosis
Animals ; Crotalus ; Diagnosis, Differential ; Humans ; Male ; Middle Aged ; Snake Bites/drug therapy
Czasopismo naukowe
Tytuł :
Probing Specificity of Protein-Protein Interactions with Chiral Plasmonic Nanostructures.
Autorzy :
Rodier M; School of Chemistry, Joseph Black Building , University of Glasgow , Glasgow G12 8QQ , U.K.
Keijzer C; School of Chemistry, Joseph Black Building , University of Glasgow , Glasgow G12 8QQ , U.K.; Institute of Molecular, Cell and Systems Biology , University of Glasgow , Glasgow G12 8TA , U.K.
Milner J; Institute of Molecular, Cell and Systems Biology , University of Glasgow , Glasgow G12 8TA , U.K.
Karimullah AS; School of Chemistry, Joseph Black Building , University of Glasgow , Glasgow G12 8QQ , U.K.
Barron LD; School of Chemistry, Joseph Black Building , University of Glasgow , Glasgow G12 8QQ , U.K.
Gadegaard N; School of Engineering, Rankine Building , University of Glasgow , Glasgow G12 8LT , U.K.
Lapthorn AJ; School of Chemistry, Joseph Black Building , University of Glasgow , Glasgow G12 8QQ , U.K.
Kadodwala M; School of Chemistry, Joseph Black Building , University of Glasgow , Glasgow G12 8QQ , U.K.
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Źródło :
The journal of physical chemistry letters [J Phys Chem Lett] 2019 Oct 17; Vol. 10 (20), pp. 6105-6111. Date of Electronic Publication: 2019 Sep 30.
Typ publikacji :
Journal Article
MeSH Terms :
Immunoglobulin Fab Fragments/*metabolism
Immunoglobulin G/*metabolism
Nanostructures/*chemistry
Polycarboxylate Cement/*chemistry
Serum Albumin, Bovine/*metabolism
Animals ; Anisotropy ; Cattle ; Gold/chemistry ; Immunoglobulin Fab Fragments/immunology ; Immunoglobulin G/immunology ; Ovalbumin/immunology ; Ovalbumin/metabolism ; Protein Binding ; Rabbits ; Serum Albumin, Bovine/immunology ; Spectrum Analysis/methods ; Stereoisomerism
Czasopismo naukowe

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