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Tytuł :
Efficacy of booster doses in augmenting waning immune responses to COVID-19 vaccine in patients with cancer.
Autorzy :
Shapiro LC; Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Thakkar A; Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Campbell ST; Department of Pathology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Forest SK; Department of Pathology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Pradhan K; Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Gonzalez-Lugo JD; Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Quinn R; Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Bhagat TD; Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Choudhary GS; Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.
McCort M; Division of Infectious Diseases, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Sica RA; Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Goldfinger M; Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Goel S; Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Anampa JD; Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Levitz D; Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Fromowitz A; Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Shah AP; Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Sklow C; Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Alfieri G; Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Racine A; Department of Pediatrics, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Wolgast L; Department of Pathology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Greenberger L; The Leukemia & Lymphoma Society, Rye Brook, NY, USA.
Verma A; Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address: .
Halmos B; Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address: .
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Źródło :
Cancer cell [Cancer Cell] 2022 Jan 10; Vol. 40 (1), pp. 3-5. Date of Electronic Publication: 2021 Nov 16.
Typ publikacji :
Letter; Research Support, N.I.H., Extramural
MeSH Terms :
Immunization, Secondary*
Antibodies, Viral/*biosynthesis
COVID-19/*prevention & control
COVID-19 Vaccines/*immunology
Immunoglobulin G/*biosynthesis
Neoplasms/*immunology
SARS-CoV-2/*immunology
Agammaglobulinaemia Tyrosine Kinase/antagonists & inhibitors ; Antibodies, Viral/blood ; Antibodies, Viral/immunology ; Antigens, Viral/immunology ; COVID-19/complications ; COVID-19/immunology ; Follow-Up Studies ; Humans ; Immunocompromised Host ; Immunogenicity, Vaccine ; Immunoglobulin G/blood ; Immunoglobulin G/immunology ; Neoplasms/complications ; Neoplasms/drug therapy ; Prospective Studies ; Protein Kinase Inhibitors/adverse effects ; Protein Kinase Inhibitors/therapeutic use ; Rituximab/adverse effects ; Rituximab/therapeutic use ; Seroconversion ; Spike Glycoprotein, Coronavirus/immunology ; Vaccination
Raport
Tytuł :
Fc-engineered antibodies with immune effector functions completely abolished.
Autorzy :
Wilkinson I; Absolute Antibody Ltd, Wilton, United Kingdom.; mAbsolve Limited, Oxford, United Kingdom.
Anderson S; Absolute Antibody Ltd, Wilton, United Kingdom.
Fry J; ProImmune Limited, Oxford, United Kingdom.
Julien LA; Antibody Analytics Limited, Motherwell, Scotland.
Neville D; Reading Scientific Services Limited, Reading, United Kingdom.
Qureshi O; Celentyx Limited, Birmingham, United Kingdom.
Watts G; Abzena Limited, Babraham, United Kingdom.
Hale G; mAbsolve Limited, Oxford, United Kingdom.
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Źródło :
PloS one [PLoS One] 2021 Dec 21; Vol. 16 (12), pp. e0260954. Date of Electronic Publication: 2021 Dec 21 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibody-Dependent Cell Cytotoxicity*
Complement C1q/*metabolism
Histocompatibility Antigens Class I/*metabolism
Immunoglobulin Fc Fragments/*metabolism
Immunoglobulin G/*metabolism
Receptors, Fc/*metabolism
Receptors, IgG/*metabolism
Amino Acid Substitution ; Antibody Affinity ; Complement C1q/genetics ; Complement C1q/immunology ; Histocompatibility Antigens Class I/genetics ; Histocompatibility Antigens Class I/immunology ; Humans ; Immunoglobulin Fc Fragments/genetics ; Immunoglobulin Fc Fragments/immunology ; Immunoglobulin G/genetics ; Immunoglobulin G/immunology ; Protein Binding ; Protein Engineering ; Receptors, Fc/genetics ; Receptors, Fc/immunology ; Receptors, IgG/genetics ; Receptors, IgG/immunology
Czasopismo naukowe
Tytuł :
Generation, biochemical characterizations and validation of potent nanobodies derived from alpaca specific for human receptor of advanced glycation end product.
Autorzy :
Mohammed A; Department of Obstetrics and Gynecology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, China.
Zeng W; Hefei National Laboratory for Physical Sciences at Microscale, Laboratory of Structural Immunology, CAS Key Laboratory of Innate Immunity and Chronic Disease, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230027, China; Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, China.
Mengist HM; Hefei National Laboratory for Physical Sciences at Microscale, Laboratory of Structural Immunology, CAS Key Laboratory of Innate Immunity and Chronic Disease, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230027, China.
Kombe Kombe AJ; Hefei National Laboratory for Physical Sciences at Microscale, Laboratory of Structural Immunology, CAS Key Laboratory of Innate Immunity and Chronic Disease, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230027, China.
Ou H; Hefei National Laboratory for Physical Sciences at Microscale, Laboratory of Structural Immunology, CAS Key Laboratory of Innate Immunity and Chronic Disease, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230027, China.
Yang Y; Hefei National Laboratory for Physical Sciences at Microscale, Laboratory of Structural Immunology, CAS Key Laboratory of Innate Immunity and Chronic Disease, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230027, China.
Dan Z; Hefei National Laboratory for Physical Sciences at Microscale, Laboratory of Structural Immunology, CAS Key Laboratory of Innate Immunity and Chronic Disease, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230027, China.
Xu Z; Department of Obstetrics and Gynecology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, China; Hefei National Laboratory for Physical Sciences at Microscale, Laboratory of Structural Immunology, CAS Key Laboratory of Innate Immunity and Chronic Disease, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230027, China.
Ma H; Hefei National Laboratory for Physical Sciences at Microscale, Laboratory of Structural Immunology, CAS Key Laboratory of Innate Immunity and Chronic Disease, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230027, China; Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, China. Electronic address: .
Jin T; Department of Obstetrics and Gynecology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, China; Hefei National Laboratory for Physical Sciences at Microscale, Laboratory of Structural Immunology, CAS Key Laboratory of Innate Immunity and Chronic Disease, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230027, China; CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Science, Shanghai, 200031, China. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Dec 03; Vol. 581, pp. 38-45. Date of Electronic Publication: 2021 Oct 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Glycation End Products, Advanced/*chemistry
Immunoglobulin Fc Fragments/*chemistry
Immunoglobulin G/*chemistry
Receptor for Advanced Glycation End Products/*chemistry
Recombinant Fusion Proteins/*chemistry
Single-Domain Antibodies/*biosynthesis
Amino Acid Sequence ; Animals ; Binding Sites ; Camelids, New World ; Cloning, Molecular ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Gene Expression ; Genetic Vectors/chemistry ; Genetic Vectors/metabolism ; Glycation End Products, Advanced/genetics ; Glycation End Products, Advanced/immunology ; HEK293 Cells ; Humans ; Immunoglobulin Fc Fragments/genetics ; Immunoglobulin Fc Fragments/immunology ; Immunoglobulin G/genetics ; Immunoglobulin G/immunology ; Peptide Library ; Protein Binding ; Protein Domains ; Protein Interaction Domains and Motifs ; Protein Multimerization ; Receptor for Advanced Glycation End Products/antagonists & inhibitors ; Receptor for Advanced Glycation End Products/genetics ; Receptor for Advanced Glycation End Products/immunology ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/metabolism ; Sequence Alignment ; Sequence Homology, Amino Acid ; Single-Domain Antibodies/chemistry ; Single-Domain Antibodies/isolation & purification
Czasopismo naukowe
Tytuł :
Immunoglobulin-binding protein-based affinity chromatography in bispecific antibody purification: Functions beyond product capture.
Autorzy :
Li Y; Technology and Process Development (TPD), WuXi Biologics, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai, 200131, China. Electronic address: .
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Źródło :
Protein expression and purification [Protein Expr Purif] 2021 Dec; Vol. 188, pp. 105976. Date of Electronic Publication: 2021 Sep 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Antibodies, Bispecific/*isolation & purification
Antibodies, Monoclonal/*isolation & purification
Bacterial Proteins/*chemistry
Chromatography, Affinity/*methods
Immunoglobulin G/*isolation & purification
Staphylococcal Protein A/*chemistry
Antibodies, Bispecific/chemistry ; Antibodies, Bispecific/metabolism ; Antibodies, Monoclonal/chemistry ; Antibodies, Monoclonal/metabolism ; Bacterial Proteins/metabolism ; Humans ; Immunoglobulin G/chemistry ; Immunoglobulin G/metabolism ; Immunoglobulin kappa-Chains/chemistry ; Immunoglobulin kappa-Chains/isolation & purification ; Immunoglobulin kappa-Chains/metabolism ; Immunoglobulin lambda-Chains/chemistry ; Immunoglobulin lambda-Chains/isolation & purification ; Immunoglobulin lambda-Chains/metabolism ; Lymphokines/chemistry ; Lymphokines/metabolism ; Protein Binding ; Staphylococcal Protein A/metabolism
Czasopismo naukowe
Tytuł :
Heritability Enrichment of Immunoglobulin G N-Glycosylation in Specific Tissues.
Autorzy :
Li X; Centre for Precision Health, Edith Cowan University, Joondalup, WA, Australia.; School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.
Wang H; School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.; Beijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, China.
Zhu Y; Beijing Lucidus Bioinformation Technology Co., Ltd., Beijing, China.
Cao W; School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.; Beijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, China.
Song M; School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.; Beijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, China.
Wang Y; Beijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, China.
Hou H; School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, China.
Lang M; Chinese Academy of Sciences (CAS) Center for Excellence in Biotic Interactions, College of Life Science, University of Chinese Academy of Sciences, Beijing, China.
Guo X; Beijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, China.
Tan X; The First Affiliated Hospital, Shantou University Medical College, Shantou, China.
Han JJ; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Center for Quantitative Biology (CQB), Peking University, Beijing, China.
Wang W; Centre for Precision Health, Edith Cowan University, Joondalup, WA, Australia.; School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.; Beijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, China.; School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, China.; The First Affiliated Hospital, Shantou University Medical College, Shantou, China.
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Źródło :
Frontiers in immunology [Front Immunol] 2021 Nov 03; Vol. 12, pp. 741705. Date of Electronic Publication: 2021 Nov 03 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Asparagine/*genetics
Genetic Loci/*genetics
Immunoglobulin G/*metabolism
Inflammatory Bowel Diseases/*genetics
Lupus Erythematosus, Systemic/*genetics
Parkinson Disease/*genetics
Gene Expression Profiling ; Genome-Wide Association Study ; Genotype ; Glycosylation ; Humans ; Immunoglobulin G/genetics ; Linkage Disequilibrium ; Organ Specificity ; Phenotype ; Polymorphism, Single Nucleotide ; Polysaccharides/metabolism ; Quantitative Trait Loci
Czasopismo naukowe
Tytuł :
Access to ultra-long IgG CDRH3 bovine antibody sequences using short read sequencing technology.
Autorzy :
Oyola SO; International Livestock Research Institute (ILRI), P.O. Box 30709 -00100, Nairobi, Kenya. Electronic address: .
Henson SP; International Livestock Research Institute (ILRI), P.O. Box 30709 -00100, Nairobi, Kenya. Electronic address: .
Nzau B; International Livestock Research Institute (ILRI), P.O. Box 30709 -00100, Nairobi, Kenya.
Kibwana E; International Livestock Research Institute (ILRI), P.O. Box 30709 -00100, Nairobi, Kenya.
Nene V; International Livestock Research Institute (ILRI), P.O. Box 30709 -00100, Nairobi, Kenya.
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Źródło :
Molecular immunology [Mol Immunol] 2021 Nov; Vol. 139, pp. 97-105. Date of Electronic Publication: 2021 Aug 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Complementarity Determining Regions/*genetics
Immunoglobulin G/*genetics
Immunoglobulin Heavy Chains/*genetics
Polymerase Chain Reaction/*methods
Sequence Analysis, Protein/*methods
Amino Acid Sequence ; Animals ; Cattle ; Complementarity Determining Regions/analysis ; Complementarity Determining Regions/chemistry ; Immunoglobulin G/analysis ; Immunoglobulin G/chemistry ; Immunoglobulin Heavy Chains/analysis ; Immunoglobulin Heavy Chains/chemistry
Czasopismo naukowe
Tytuł :
Intralesional TTI-621, a novel biologic targeting the innate immune checkpoint CD47, in patients with relapsed or refractory mycosis fungoides or Sézary syndrome: a multicentre, phase 1 study.
Autorzy :
Querfeld C; Division of Dermatology, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, USA. Electronic address: .
Thompson JA; Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Taylor MH; Earle A Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA.
DeSimone JA; Melanoma and Skin Oncology Center, Inova Health System, Fairfax, VA, USA.
Zain JM; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA, USA.
Shustov AR; Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Johns C; School of Medicine, Oregon Health and Science University, Portland, OR, USA.
McCann S; Department of Dermatology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Lin GHY; Trillium Therapeutics, Mississauga, ON, Canada.
Petrova PS; Trillium Therapeutics, Mississauga, ON, Canada.
Uger RA; Trillium Therapeutics, Mississauga, ON, Canada.
Molloy N; Trillium Therapeutics, Mississauga, ON, Canada.
Shou Y; Trillium Therapeutics, Mississauga, ON, Canada.
Akilov OE; Department of Dermatology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
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Źródło :
The Lancet. Haematology [Lancet Haematol] 2021 Nov; Vol. 8 (11), pp. e808-e817. Date of Electronic Publication: 2021 Oct 07.
Typ publikacji :
Clinical Trial, Phase I; Journal Article; Multicenter Study
MeSH Terms :
CD47 Antigen/*antagonists & inhibitors
Immune Checkpoint Inhibitors/*therapeutic use
Immunoglobulin G/*therapeutic use
Mycosis Fungoides/*drug therapy
Sezary Syndrome/*drug therapy
Skin Neoplasms/*drug therapy
Aged ; CD47 Antigen/immunology ; Female ; Humans ; Immune Checkpoint Inhibitors/administration & dosage ; Immune Checkpoint Inhibitors/adverse effects ; Immunoglobulin G/administration & dosage ; Immunoglobulin G/adverse effects ; Male ; Maximum Tolerated Dose ; Middle Aged ; Mycosis Fungoides/immunology ; Neoplasm Recurrence, Local/drug therapy ; Neoplasm Recurrence, Local/immunology ; Sezary Syndrome/immunology ; Skin Neoplasms/immunology
Czasopismo naukowe
Tytuł :
IgG3 and IgM Identified as Key to SARS-CoV-2 Neutralization in Convalescent Plasma Pools.
Autorzy :
Kober C; Research & Development, CSL Behring Innovation GmbH, Marburg, Germany.
Manni S; Research & Development, CSL Behring, Bern, Switzerland.
Wolff S; Research & Development, CSL Behring Innovation GmbH, Marburg, Germany.
Barnes T; Research & Development, CSL Behring, Bern, Switzerland.
Mukherjee S; Research & Development, CSL Behring Innovation GmbH, Marburg, Germany.
Vogel T; Research & Development, CSL Behring Innovation GmbH, Marburg, Germany.
Hoenig L; Research & Development, CSL Behring, Bern, Switzerland.
Vogel P; Research & Development, CSL Behring Innovation GmbH, Marburg, Germany.
Hahn A; Research & Development, CSL Behring Innovation GmbH, Marburg, Germany.
Gerlach M; Research & Development, CSL Behring Innovation GmbH, Marburg, Germany.
Vey M; Research & Development, CSL Behring Innovation GmbH, Marburg, Germany.
Widmer E; Research & Development, CSL Behring, Bern, Switzerland.
Keiner B; Research & Development, CSL Behring Innovation GmbH, Marburg, Germany.
Schuetz P; Research & Development, CSL Behring, Bern, Switzerland.
Roth N; Research & Development, CSL Behring, Bern, Switzerland.
Kalina U; Research & Development, CSL Behring Innovation GmbH, Marburg, Germany.
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Źródło :
PloS one [PLoS One] 2022 Jan 04; Vol. 17 (1), pp. e0262162. Date of Electronic Publication: 2022 Jan 04 (Print Publication: 2022).
Typ publikacji :
Journal Article
MeSH Terms :
Convalescence*
Antibodies, Neutralizing/*immunology
Antibodies, Viral/*immunology
COVID-19/*blood
COVID-19/*immunology
Immunoglobulin G/*immunology
Animals ; Antibodies, Neutralizing/blood ; Antibodies, Viral/blood ; Chlorocebus aethiops ; Enzyme-Linked Immunosorbent Assay ; Humans ; Immunoglobulin G/blood ; Immunoglobulin M/blood ; Immunoglobulin M/immunology ; SARS-CoV-2/physiology ; Vero Cells
Czasopismo naukowe
Tytuł :
Distinct durability of IgM/IgG antibody responses in COVID-19 patients with differing severity.
Autorzy :
Han J; Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.
Zhang N; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID), Chinese Academy of Sciences, Beijing, 100101, China.
Chen D; Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.
Gong Y; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID), Chinese Academy of Sciences, Beijing, 100101, China.; Institutes of Physical Science and Information Technology, Anhui University, Hefei, 230601, China.
Li G; Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.
Kong Y; Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.
Pu L; Intensive Care Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.
Chen C; Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.
Liu J; Intensive Care Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.
Wang Q; Center of Liver Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.
Zhang J; Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.
Zhao X; Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.
Du J; Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.
Han K; Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.
Song C; Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.
Wang L; Laboratory of Infectious Diseases Center of Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.
Hua M; Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.
Hao Y; Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.
Song R; The Infectious Disease Diagnostic, Therapeutic and Research Centers, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.
Song Y; Clinical Center for HIV/AIDS, Clinical and Research Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.
Yu F; Clinical Center for HIV/AIDS, Clinical and Research Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.
Yang S; Laboratory of Infectious Diseases Center of Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.
Xiong H; Intensive Care Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.
Zhang W; The Infectious Disease Diagnostic, Therapeutic and Research Centers, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.
Gao GF; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID), Chinese Academy of Sciences, Beijing, 100101, China. .; University of Chinese Academy of Sciences, Beijing, 100049, China. .
Zhang F; Clinical Center for HIV/AIDS, Clinical and Research Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China. .
Li A; Intensive Care Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China. .
Zeng H; Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China. .
Bi Y; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID), Chinese Academy of Sciences, Beijing, 100101, China. .; University of Chinese Academy of Sciences, Beijing, 100049, China. .
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Źródło :
Science China. Life sciences [Sci China Life Sci] 2022 Jan; Vol. 65 (1), pp. 223-226. Date of Electronic Publication: 2021 Jun 02.
Typ publikacji :
Letter; Comment
MeSH Terms :
COVID-19*
Immunoglobulin G*
Antibodies, Viral ; Antibody Formation ; Humans ; Immunoglobulin M ; SARS-CoV-2
Opinia redakcyjna
Tytuł :
Incomplete IgG avidity maturation after seasonal coronavirus infections.
Autorzy :
Struck F; Mikrogen GmbH, Neuried, Germany.
Schreiner P; Mikrogen GmbH, Neuried, Germany.
Staschik E; Mikrogen GmbH, Neuried, Germany.
Wochinz-Richter K; Mikrogen GmbH, Neuried, Germany.
Schulz S; Mikrogen GmbH, Neuried, Germany.
Soutschek E; Mikrogen GmbH, Neuried, Germany.
Motz M; Mikrogen GmbH, Neuried, Germany.
Bauer G; Institute of Virology, Medical Center, University of Freiburg, Freiburg im Breisgau, Germany.; Faculty of Medicine, University of Freiburg, Freiburg, Germany.
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Źródło :
Journal of medical virology [J Med Virol] 2022 Jan; Vol. 94 (1), pp. 186-196. Date of Electronic Publication: 2021 Aug 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibody Affinity*
Alphacoronavirus/*immunology
Betacoronavirus/*immunology
COVID-19/*immunology
Coronavirus Infections/*immunology
Immunoglobulin G/*immunology
SARS-CoV-2/*immunology
Adolescent ; Adult ; Aged ; Antibodies, Viral/blood ; Antibodies, Viral/immunology ; Coronavirus NL63, Human/immunology ; Coronavirus Nucleocapsid Proteins/immunology ; Coronavirus OC43, Human/immunology ; Cross Reactions ; Female ; Humans ; Immunoglobulin G/blood ; Male ; Middle Aged ; Phosphoproteins/immunology ; Seasons ; Young Adult
Czasopismo naukowe
Tytuł :
The 12-week kinetics of anti-SARS-CoV-2 antibodies in different haematological cancers after vaccination with BNT162b2.
Autorzy :
Marchesi F; Haematology Unit, Department of Research and Clinical Oncology, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
Pimpinelli F; Microbiology and Virology Unit, Dermatological Clinical and Research Department, IRCCS San Gallicano Institute, Rome, Italy.
Sperandio E; Biostatistics and Bioinformatics Unit, Scientific Direction, Clinical Trial Center, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
Papa E; Haematology Unit, Department of Research and Clinical Oncology, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
Falcucci P; Haematology Unit, Department of Research and Clinical Oncology, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
Pontone M; Microbiology and Virology Unit, Dermatological Clinical and Research Department, IRCCS San Gallicano Institute, Rome, Italy.
di Martino S; Biological Tissue and Liquid Bank, Scientific Direction, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
de Latouliere L; SAFU Unit, Department of Research and Innovative Technologies, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
Orlandi G; Oncogenomic and Epigenetic Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
Morrone A; Scientific Direction, IRCCS San Gallicano Institute, Rome, Italy.
Ciliberto G; Scientific Direction, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
Mengarelli A; Haematology Unit, Department of Research and Clinical Oncology, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
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Corporate Authors :
I.F.O.-COVID-19-Team
Źródło :
British journal of haematology [Br J Haematol] 2022 Jan; Vol. 196 (2), pp. 362-367. Date of Electronic Publication: 2021 Sep 06.
Typ publikacji :
Letter
MeSH Terms :
Antibodies, Neutralizing/*blood
Antibodies, Viral/*blood
BNT162 Vaccine/*immunology
COVID-19/*prevention & control
Immunoglobulin G/*blood
SARS-CoV-2/*immunology
Aged ; Antibodies, Neutralizing/biosynthesis ; Antibodies, Viral/biosynthesis ; Cohort Studies ; Female ; Hematologic Neoplasms/immunology ; Humans ; Immunogenicity, Vaccine ; Immunoglobulin G/biosynthesis ; Kinetics ; Leukemia/immunology ; Lymphoma, Non-Hodgkin/immunology ; Male ; Middle Aged ; Multiple Myeloma/immunology ; Myeloproliferative Disorders/immunology ; Time Factors ; Vaccination
Opinia redakcyjna
Tytuł :
Robust humoral and cellular immune responses and low risk for reinfection at least 8 months following asymptomatic to mild COVID-19.
Autorzy :
Havervall S; Department of Clinical Sciences, Karolinska Institutet Danderyd Hospital, Stockholm, Sweden.
Ng H; Department of Clinical Sciences, Karolinska Institutet Danderyd Hospital, Stockholm, Sweden.; Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden.
Jernbom Falk A; Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden.
Greilert-Norin N; Department of Clinical Sciences, Karolinska Institutet Danderyd Hospital, Stockholm, Sweden.
Månberg A; Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden.
Marking U; Department of Clinical Sciences, Karolinska Institutet Danderyd Hospital, Stockholm, Sweden.
Laurén I; Department of Pharmacy, Uppsala University, Uppsala, Sweden.
Gabrielsson L; Department of Clinical Sciences, Karolinska Institutet Danderyd Hospital, Stockholm, Sweden.
Salomonsson AC; Department of Clinical Sciences, Karolinska Institutet Danderyd Hospital, Stockholm, Sweden.
Aguilera K; Department of Clinical Sciences, Karolinska Institutet Danderyd Hospital, Stockholm, Sweden.
Kihlgren M; Department of Clinical Sciences, Karolinska Institutet Danderyd Hospital, Stockholm, Sweden.
Månsson M; Department of Clinical Sciences, Karolinska Institutet Danderyd Hospital, Stockholm, Sweden.
Rosell A; Department of Clinical Sciences, Karolinska Institutet Danderyd Hospital, Stockholm, Sweden.
Hellström C; Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden.
Andersson E; Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden.
Olofsson J; Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden.
Skoglund L; Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden.
Yousef J; Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden.
Pin E; Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden.
Lord M; Department of Pharmacy, Uppsala University, Uppsala, Sweden.
Åberg M; Department of Medical Sciences, Clinical Chemistry and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Hedhammar M; Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden.
Tegel H; Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden.
Dönnes P; SciCross AB, Skövde, Sweden.
Phillipson M; Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden.
Nilsson P; Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden.
Klingström J; Centre for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
Mangsbo S; Department of Pharmacy, Uppsala University, Uppsala, Sweden.
Hober S; Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden.
Thålin C; Department of Clinical Sciences, Karolinska Institutet Danderyd Hospital, Stockholm, Sweden.
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Źródło :
Journal of internal medicine [J Intern Med] 2022 Jan; Vol. 291 (1), pp. 72-80. Date of Electronic Publication: 2021 Sep 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunity, Cellular*
Immunity, Humoral*
Reinfection*
Antibodies, Viral/*blood
COVID-19/*diagnosis
COVID-19/*immunology
Immunoglobulin G/*immunology
Adult ; Antibodies, Viral/immunology ; Asymptomatic Infections ; COVID-19 Nucleic Acid Testing ; COVID-19 Serological Testing ; Female ; Humans ; Immunoglobulin G/blood ; Male ; Memory T Cells ; Middle Aged ; Pandemics ; SARS-CoV-2 ; Time Factors
Czasopismo naukowe
Tytuł :
Physical mixture of a cyclic lipopeptide vaccine induced high titres of opsonic IgG antibodies against group A streptococcus.
Autorzy :
Madge HYR; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane 4072, Australia. .
Huang W; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane 4072, Australia. .
Gilmartin L; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane 4072, Australia. .
Rigau-Planella B; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane 4072, Australia. .
Hussein WM; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane 4072, Australia. .
Khalil ZG; Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia.
Koirala P; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane 4072, Australia. .
Santiago VS; Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia.
Capon RJ; Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia.
Toth I; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane 4072, Australia. .; Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia.; School of Pharmacy, The University of Queensland, Brisbane 4072, Australia.
Stephenson RJ; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane 4072, Australia. .
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Źródło :
Biomaterials science [Biomater Sci] 2021 Dec 21; Vol. 10 (1), pp. 281-293. Date of Electronic Publication: 2021 Dec 21.
Typ publikacji :
Journal Article
MeSH Terms :
Immunoglobulin G*/blood
Peptides, Cyclic*
Vaccines*
Streptococcal Infections/*prevention & control
Adjuvants, Immunologic ; Animals ; Antibodies, Bacterial/blood ; Female ; HEK293 Cells ; Humans ; Lipopeptides ; Mice, Inbred C57BL ; Streptococcus pyogenes
Czasopismo naukowe
Tytuł :
SARS-CoV-2 receptor binding domain fusion protein efficiently neutralizes virus infection.
Autorzy :
Chaouat AE; The Concern Foundation Laboratories at the Lautenberg Center for Immunology and Cancer Research, Institute for Medical Research Israel Canada (IMRIC), The Hebrew University Hadassah Medical School, Jerusalem, Israel.
Achdout H; Department of Infectious Diseases, Israel Institute for Biological Research, Ness Ziona, Israel.
Kol I; The Concern Foundation Laboratories at the Lautenberg Center for Immunology and Cancer Research, Institute for Medical Research Israel Canada (IMRIC), The Hebrew University Hadassah Medical School, Jerusalem, Israel.
Berhani O; The Concern Foundation Laboratories at the Lautenberg Center for Immunology and Cancer Research, Institute for Medical Research Israel Canada (IMRIC), The Hebrew University Hadassah Medical School, Jerusalem, Israel.
Roi G; The Concern Foundation Laboratories at the Lautenberg Center for Immunology and Cancer Research, Institute for Medical Research Israel Canada (IMRIC), The Hebrew University Hadassah Medical School, Jerusalem, Israel.
Vitner EB; Department of Infectious Diseases, Israel Institute for Biological Research, Ness Ziona, Israel.
Melamed S; Department of Infectious Diseases, Israel Institute for Biological Research, Ness Ziona, Israel.
Politi B; Department of Infectious Diseases, Israel Institute for Biological Research, Ness Ziona, Israel.
Zahavy E; Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness Ziona, Israel.
Brizic I; Center for Proteomics, Faculty of Medicine, University of Rijeka, Rijeka, Croatia.
Lenac Rovis T; Center for Proteomics, Faculty of Medicine, University of Rijeka, Rijeka, Croatia.
Alfi O; Lautenberg Center for General and Tumor Immunology, The Hebrew University Faculty of Medicine, Jerusalem, Israel.; Clinical Virology Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel.
Wolf D; Lautenberg Center for General and Tumor Immunology, The Hebrew University Faculty of Medicine, Jerusalem, Israel.; Clinical Virology Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel.
Jonjic S; Center for Proteomics, Faculty of Medicine, University of Rijeka, Rijeka, Croatia.
Israely T; Department of Infectious Diseases, Israel Institute for Biological Research, Ness Ziona, Israel.
Mandelboim O; The Concern Foundation Laboratories at the Lautenberg Center for Immunology and Cancer Research, Institute for Medical Research Israel Canada (IMRIC), The Hebrew University Hadassah Medical School, Jerusalem, Israel.
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Źródło :
PLoS pathogens [PLoS Pathog] 2021 Dec 20; Vol. 17 (12), pp. e1010175. Date of Electronic Publication: 2021 Dec 20 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Domains*
Angiotensin-Converting Enzyme 2/*antagonists & inhibitors
Immunoglobulin Fc Fragments/*metabolism
Immunoglobulin G/*metabolism
Recombinant Fusion Proteins/*metabolism
SARS-CoV-2/*metabolism
Angiotensin-Converting Enzyme 2/metabolism ; Animals ; Binding Sites ; Binding Sites, Antibody ; COVID-19/prevention & control ; Chlorocebus aethiops ; Female ; HEK293 Cells ; Humans ; Immunoglobulin Fc Fragments/therapeutic use ; Immunoglobulin G/therapeutic use ; Mice, Transgenic ; Neutralization Tests ; Protein Binding ; Recombinant Fusion Proteins/therapeutic use ; SARS-CoV-2/drug effects ; Vero Cells
Czasopismo naukowe
Tytuł :
Myelin oligodendrocyte glycoprotein (MOG) antibodies in a patient with glioblastoma: Red flags for false positivity.
Autorzy :
Amin M; Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.
Mays M; Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.
Polston D; Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.
Flanagan EP; Department of Neurology and Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Prayson R; Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH, USA.
Kunchok A; Neurological Institute, Cleveland Clinic, Cleveland, OH, USA. Electronic address: .
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Źródło :
Journal of neuroimmunology [J Neuroimmunol] 2021 Dec 15; Vol. 361, pp. 577743. Date of Electronic Publication: 2021 Oct 08.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Diagnostic Errors*
Antibodies, Neoplasm/*blood
Autoantibodies/*blood
Autoantigens/*immunology
Brain Neoplasms/*immunology
Glioblastoma/*immunology
Immunoglobulin G/*blood
Myelin-Oligodendrocyte Glycoprotein/*immunology
Adult ; Autoantibodies/immunology ; Biopsy ; Brain Neoplasms/blood ; Brain Neoplasms/diagnostic imaging ; Delayed Diagnosis ; Facial Paralysis/etiology ; False Positive Reactions ; Female ; Gait Disorders, Neurologic/etiology ; Glioblastoma/blood ; Glioblastoma/diagnostic imaging ; Humans ; Immunoglobulin G/immunology ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy ; Neuroimaging ; Paresis/etiology ; Positron-Emission Tomography ; Vertigo/etiology ; Vision Disorders/etiology
Czasopismo naukowe
Tytuł :
Unexplored Excipients in Biotherapeutic Formulations: Natural Osmolytes as Potential Stabilizers Against Thermally Induced Aggregation of IgG1 Biotherapeutics.
Autorzy :
Bhojane PP; Department of Chemical Engineering, Indian Institute of Technology, Hauz Khas, New Delhi, 110016, India.
Joshi S; Department of Chemical Engineering, Indian Institute of Technology, Hauz Khas, New Delhi, 110016, India.
Sahoo SJ; Department of Chemical Engineering, Indian Institute of Technology, Hauz Khas, New Delhi, 110016, India.
Rathore AS; Department of Chemical Engineering, Indian Institute of Technology, Hauz Khas, New Delhi, 110016, India. .
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Źródło :
AAPS PharmSciTech [AAPS PharmSciTech] 2021 Dec 14; Vol. 23 (1), pp. 26. Date of Electronic Publication: 2021 Dec 14.
Typ publikacji :
Journal Article
MeSH Terms :
Excipients*
Immunoglobulin G*
Antibodies, Monoclonal ; Calorimetry, Differential Scanning ; Protein Aggregates
Czasopismo naukowe
Tytuł :
Antibody Titers Before and After a Third Dose of the SARS-CoV-2 BNT162b2 Vaccine in Adults Aged ≥60 Years.
Autorzy :
Eliakim-Raz N; Rabin Medical Center, Tel Aviv University Sackler School of Medicine, Tel Aviv, Israel.
Leibovici-Weisman Y; Rabin Medical Center, Tel Aviv University Sackler School of Medicine, Tel Aviv, Israel.
Stemmer A; Department of Oncology, Sheba Medical Center, Tel Hashomer, Israel.
Ness A; Rabin Medical Center, Tel Aviv University Sackler School of Medicine, Tel Aviv, Israel.
Awwad M; Rabin Medical Center, Tel Aviv University Sackler School of Medicine, Tel Aviv, Israel.
Ghantous N; Rabin Medical Center, Tel Aviv University Sackler School of Medicine, Tel Aviv, Israel.
Stemmer SM; Rabin Medical Center, Tel Aviv University Sackler School of Medicine, Tel Aviv, Israel.
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Źródło :
JAMA [JAMA] 2021 Dec 07; Vol. 326 (21), pp. 2203-2204.
Typ publikacji :
Journal Article
MeSH Terms :
Antibodies, Viral/*blood
COVID-19/*prevention & control
COVID-19 Vaccines/*administration & dosage
Immunoglobulin G/*blood
RNA, Messenger/*immunology
RNA, Viral/*immunology
SARS-CoV-2/*immunology
Aged ; Aged, 80 and over ; Antibodies, Viral/immunology ; BNT162 Vaccine ; COVID-19/immunology ; COVID-19 Vaccines/genetics ; COVID-19 Vaccines/immunology ; Female ; Humans ; Immunoglobulin G/immunology ; Male ; Middle Aged ; RNA, Messenger/administration & dosage ; RNA, Messenger/blood ; RNA, Viral/administration & dosage ; RNA, Viral/genetics ; SARS-CoV-2/genetics ; Treatment Outcome
Czasopismo naukowe
Tytuł :
IgG1 conformational behavior: elucidation of the N-glycosylation role via molecular dynamics.
Autorzy :
Saporiti S; Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milano, Italy.
Parravicini C; Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milano, Italy.
Pergola C; Analytical Development Biotech, Merck Serono S.p.A., Rome, Italy.
Guerrini U; Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milano, Italy.
Rossi M; Global Analytical Pharmaceutical Science and Innovation, Merck Serono S.p.A., Rome, Italy.
Centola F; Global Analytical Pharmaceutical Science and Innovation, Merck Serono S.p.A., Rome, Italy.
Eberini I; Dipartimento di Scienze Farmacologiche e Biomolecolari & DSRC, Università degli Studi di Milano, Milano, Italy. Electronic address: .
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Źródło :
Biophysical journal [Biophys J] 2021 Dec 07; Vol. 120 (23), pp. 5355-5370. Date of Electronic Publication: 2021 Oct 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunoglobulin G*/metabolism
Molecular Dynamics Simulation*
Fucose ; Glycosylation ; Humans ; Immunoglobulin Fc Fragments/metabolism
Czasopismo naukowe
Tytuł :
Insights in ChAdOx1 nCoV-19 vaccine-induced immune thrombotic thrombocytopenia.
Autorzy :
Greinacher A; Institute of Immunology and Transfusion Medicine, Department of Transfusion Medicine, University Medicine Greifswald, Greifswald, Germany.
Selleng K; Institute of Immunology and Transfusion Medicine, Department of Transfusion Medicine, University Medicine Greifswald, Greifswald, Germany.
Palankar R; Institute of Immunology and Transfusion Medicine, Department of Transfusion Medicine, University Medicine Greifswald, Greifswald, Germany.
Wesche J; Institute of Immunology and Transfusion Medicine, Department of Transfusion Medicine, University Medicine Greifswald, Greifswald, Germany.
Handtke S; Institute of Immunology and Transfusion Medicine, Department of Transfusion Medicine, University Medicine Greifswald, Greifswald, Germany.
Wolff M; Institute of Immunology and Transfusion Medicine, Department of Transfusion Medicine, University Medicine Greifswald, Greifswald, Germany.
Aurich K; Institute of Immunology and Transfusion Medicine, Department of Transfusion Medicine, University Medicine Greifswald, Greifswald, Germany.
Lalk M; Institute of Biochemistry, University of Greifswald, Greifswald, Germany.
Methling K; Institute of Biochemistry, University of Greifswald, Greifswald, Germany.
Völker U; Interfaculty Institute of Genetics and Functional Genomics, Department Functional Genomics, University Medicine Greifswald, Greifswald, Germany.; German Centre for Cardiovascular Research (DZHK), Partner Site Greifswald, Greifswald, Germany.
Hentschker C; Interfaculty Institute of Genetics and Functional Genomics, Department Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Michalik S; Interfaculty Institute of Genetics and Functional Genomics, Department Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Steil L; Interfaculty Institute of Genetics and Functional Genomics, Department Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Reder A; Interfaculty Institute of Genetics and Functional Genomics, Department Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Schönborn L; Institute of Immunology and Transfusion Medicine, Department of Transfusion Medicine, University Medicine Greifswald, Greifswald, Germany.
Beer M; Institute of Diagnostic Virology, Friedrich-Loeffler Institute, Greifswald-Insel Riems, Germany.
Franzke K; Institute of Infectious Diseases, Friedrich-Loeffler Institute, Greifswald-Insel Riems, Germany.
Büttner A; Institute of Forensic Medicine, Rostock University Medical Center, Rostock, Germany.
Fehse B; Research Department Cell & Gene Therapy, Department of Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg Germany.; German Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Germany.
Stavrou EX; Department of Medicine, Hematology and Oncology Division, CWRU School of Medicine, Cleveland, OH.; Department of Medicine, Section of Hematology-Oncology, Louis Stokes Veterans Administration Medical Center, Cleveland, OH.
Rangaswamy C; Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
Mailer RK; Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
Englert H; Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
Frye M; Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
Thiele T; Institute of Immunology and Transfusion Medicine, Department of Transfusion Medicine, University Medicine Greifswald, Greifswald, Germany.
Kochanek S; Department of Gene Therapy, Ulm University, Ulm, Germany.
Krutzke L; Department of Gene Therapy, Ulm University, Ulm, Germany.
Siegerist F; Institute of Anatomy and Cell Biology, University Medicine Greifswald, Greifswald, Germany.
Endlich N; Institute of Anatomy and Cell Biology, University Medicine Greifswald, Greifswald, Germany.; NIPOKA GmbH, Greifswald, Germany.
Warkentin TE; Department of Pathology and Molecular Medicine, and.; Department of Medicine, McMaster University, Hamilton, ON, Canada; and.
Renné T; Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.; Center for Thrombosis and Hemostasis (CTH), Johannes Gutenberg University Medical Center, Mainz, Germany.
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Źródło :
Blood [Blood] 2021 Dec 02; Vol. 138 (22), pp. 2256-2268.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Contamination*
SARS-CoV-2*
Antigen-Antibody Complex/*immunology
Autoantibodies/*immunology
COVID-19/*prevention & control
Capsid Proteins/*adverse effects
ChAdOx1 nCoV-19/*adverse effects
Genetic Vectors/*adverse effects
HEK293 Cells/*immunology
Immunoglobulin G/*immunology
Platelet Factor 4/*immunology
Purpura, Thrombocytopenic, Idiopathic/*etiology
Spike Glycoprotein, Coronavirus/*adverse effects
Adenoviridae/immunology ; Animals ; Antigen-Antibody Complex/ultrastructure ; Autoantibodies/biosynthesis ; Capillary Leak Syndrome/etiology ; Capsid Proteins/immunology ; Cell Line, Transformed ; ChAdOx1 nCoV-19/chemistry ; ChAdOx1 nCoV-19/immunology ; ChAdOx1 nCoV-19/toxicity ; Dynamic Light Scattering ; Epitopes/chemistry ; Epitopes/immunology ; Extracellular Traps/immunology ; Extravasation of Diagnostic and Therapeutic Materials/etiology ; Genetic Vectors/immunology ; HEK293 Cells/chemistry ; Humans ; Imaging, Three-Dimensional ; Immunoglobulin G/biosynthesis ; Inflammation ; Mice ; Microscopy/methods ; Platelet Activation ; Proteomics ; Purpura, Thrombocytopenic, Idiopathic/blood ; Purpura, Thrombocytopenic, Idiopathic/immunology ; Sinus Thrombosis, Intracranial/diagnostic imaging ; Sinus Thrombosis, Intracranial/immunology ; Spike Glycoprotein, Coronavirus/immunology ; Virus Cultivation
Czasopismo naukowe

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