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Tytuł :
High Potency of a Bivalent Human V H Domain in SARS-CoV-2 Animal Models.
Autorzy :
Li W; Center for Antibody Therapeutics, Division of Infectious Diseases, Department of Medicine, University of Pittsburgh Medical School, 3550 Terrace St., Pittsburgh, PA 15261, USA. Electronic address: .
Schäfer A; Department of Epidemiology, University of North Carolina at Chapel Hill, 135 Dauer Drive, 3109 Michael Hooker Research Center, Chapel Hill, NC 27599, USA.
Kulkarni SS; Vaccine and Infectious Disease Organization-International Vaccine Centre, and the Department of Veterinary Microbiology, University of Saskatchewan, 117 Veterinary Road, Saskatoon, SK S7N 5E3, Canada.
Liu X; Center for Antibody Therapeutics, Division of Infectious Diseases, Department of Medicine, University of Pittsburgh Medical School, 3550 Terrace St., Pittsburgh, PA 15261, USA.
Martinez DR; Department of Epidemiology, University of North Carolina at Chapel Hill, 135 Dauer Drive, 3109 Michael Hooker Research Center, Chapel Hill, NC 27599, USA.
Chen C; Center for Antibody Therapeutics, Division of Infectious Diseases, Department of Medicine, University of Pittsburgh Medical School, 3550 Terrace St., Pittsburgh, PA 15261, USA.
Sun Z; Center for Antibody Therapeutics, Division of Infectious Diseases, Department of Medicine, University of Pittsburgh Medical School, 3550 Terrace St., Pittsburgh, PA 15261, USA.
Leist SR; Department of Epidemiology, University of North Carolina at Chapel Hill, 135 Dauer Drive, 3109 Michael Hooker Research Center, Chapel Hill, NC 27599, USA.
Drelich A; Department of Microbiology and Immunology, Centers for Biodefense and Emerging Diseases, Galveston National Laboratory, 301 University Blvd., Galveston, TX 77550, USA.
Zhang L; Center for Antibody Therapeutics, Division of Infectious Diseases, Department of Medicine, University of Pittsburgh Medical School, 3550 Terrace St., Pittsburgh, PA 15261, USA.
Ura ML; Abound Bio, 1401 Forbes Ave., Pittsburgh, PA 15219, USA.
Berezuk A; Department of Biochemistry and Molecular Biology, University of British Columbia, Life Sciences Centre, 2350 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada.
Chittori S; Department of Biochemistry and Molecular Biology, University of British Columbia, Life Sciences Centre, 2350 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada.
Leopold K; Department of Biochemistry and Molecular Biology, University of British Columbia, Life Sciences Centre, 2350 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada.
Mannar D; Department of Biochemistry and Molecular Biology, University of British Columbia, Life Sciences Centre, 2350 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada.
Srivastava SS; Department of Biochemistry and Molecular Biology, University of British Columbia, Life Sciences Centre, 2350 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada.
Zhu X; Department of Biochemistry and Molecular Biology, University of British Columbia, Life Sciences Centre, 2350 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada.
Peterson EC; Abound Bio, 1401 Forbes Ave., Pittsburgh, PA 15219, USA.
Tseng CT; Department of Microbiology and Immunology, Centers for Biodefense and Emerging Diseases, Galveston National Laboratory, 301 University Blvd., Galveston, TX 77550, USA.
Mellors JW; Center for Antibody Therapeutics, Division of Infectious Diseases, Department of Medicine, University of Pittsburgh Medical School, 3550 Terrace St., Pittsburgh, PA 15261, USA; Abound Bio, 1401 Forbes Ave., Pittsburgh, PA 15219, USA.
Falzarano D; Vaccine and Infectious Disease Organization-International Vaccine Centre, and the Department of Veterinary Microbiology, University of Saskatchewan, 117 Veterinary Road, Saskatoon, SK S7N 5E3, Canada.
Subramaniam S; Department of Biochemistry and Molecular Biology, University of British Columbia, Life Sciences Centre, 2350 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada.
Baric RS; Department of Epidemiology, University of North Carolina at Chapel Hill, 135 Dauer Drive, 3109 Michael Hooker Research Center, Chapel Hill, NC 27599, USA.
Dimitrov DS; Center for Antibody Therapeutics, Division of Infectious Diseases, Department of Medicine, University of Pittsburgh Medical School, 3550 Terrace St., Pittsburgh, PA 15261, USA; Abound Bio, 1401 Forbes Ave., Pittsburgh, PA 15219, USA. Electronic address: .
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Źródło :
Cell [Cell] 2020 Oct 15; Vol. 183 (2), pp. 429-441.e16. Date of Electronic Publication: 2020 Sep 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Peptide Library*
Coronavirus Infections/*drug therapy
Immunoglobulin Heavy Chains/*administration & dosage
Immunoglobulin Variable Region/*administration & dosage
Pneumonia, Viral/*drug therapy
Angiotensin-Converting Enzyme 2 ; Animals ; Antibodies, Neutralizing/immunology ; Antibodies, Neutralizing/ultrastructure ; Antibodies, Viral/administration & dosage ; Antibodies, Viral/chemistry ; Antibodies, Viral/immunology ; Antibodies, Viral/ultrastructure ; Antibody Affinity ; COVID-19 ; Cricetinae ; Female ; Humans ; Immunoglobulin Fc Fragments/immunology ; Immunoglobulin Heavy Chains/chemistry ; Immunoglobulin Heavy Chains/immunology ; Immunoglobulin Heavy Chains/ultrastructure ; Immunoglobulin Variable Region/chemistry ; Immunoglobulin Variable Region/immunology ; Immunoglobulin Variable Region/ultrastructure ; Mice ; Mice, Inbred BALB C ; Mutation ; Pandemics ; Peptidyl-Dipeptidase A/metabolism ; Protein Domains ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/metabolism ; Spike Glycoprotein, Coronavirus/ultrastructure
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Structural basis of a shared antibody response to SARS-CoV-2.
Autorzy :
Yuan M; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Liu H; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Wu NC; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Lee CD; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Zhu X; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Zhao F; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.
Huang D; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Yu W; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Hua Y; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Tien H; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Rogers TF; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; Division of Infectious Diseases, Department of Medicine, University of California, San Diego, La Jolla, CA 92037, USA.
Landais E; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI, New York, NY 10004, USA.
Sok D; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI, New York, NY 10004, USA.
Jardine JG; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI, New York, NY 10004, USA.
Burton DR; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA.
Wilson IA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. .; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA.
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Źródło :
Science (New York, N.Y.) [Science] 2020 Aug 28; Vol. 369 (6507), pp. 1119-1123. Date of Electronic Publication: 2020 Jul 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibody Formation*
Antibodies, Neutralizing/*chemistry
Antibodies, Viral/*chemistry
Betacoronavirus/*immunology
Complementarity Determining Regions/*chemistry
Coronavirus Infections/*prevention & control
Immunoglobulin Heavy Chains/*chemistry
Pandemics/*prevention & control
Pneumonia, Viral/*prevention & control
Antibodies, Neutralizing/genetics ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/genetics ; Antibodies, Viral/immunology ; Binding Sites ; COVID-19 ; COVID-19 Vaccines ; Complementarity Determining Regions/genetics ; Complementarity Determining Regions/immunology ; Coronavirus Infections/genetics ; Coronavirus Infections/immunology ; Crystallography, X-Ray ; Humans ; Immunoglobulin Heavy Chains/genetics ; Immunoglobulin Heavy Chains/immunology ; Pneumonia, Viral/immunology ; Protein Domains ; SARS-CoV-2 ; Viral Vaccines/chemistry ; Viral Vaccines/genetics ; Viral Vaccines/immunology
Czasopismo naukowe
Tytuł :
CtIP-mediated DNA resection is dispensable for IgH class switch recombination by alternative end-joining.
Autorzy :
Wang XS; Institute for Cancer Genetics, Vagelos College for Physicians and Surgeons, Columbia University, New York, NY 10032.; Graduate Program of Pathobiology and Molecular Medicine, Vagelos College for Physicians and Surgeons, Columbia University, New York, NY 10032.
Zhao J; Program for Mathematical Genomics, Department of Systems Biology, Columbia University, New York, NY 10032.
Wu-Baer F; Institute for Cancer Genetics, Vagelos College for Physicians and Surgeons, Columbia University, New York, NY 10032.
Shao Z; Institute for Cancer Genetics, Vagelos College for Physicians and Surgeons, Columbia University, New York, NY 10032.
Lee BJ; Institute for Cancer Genetics, Vagelos College for Physicians and Surgeons, Columbia University, New York, NY 10032.
Cupo OM; Institute for Cancer Genetics, Vagelos College for Physicians and Surgeons, Columbia University, New York, NY 10032.
Rabadan R; Program for Mathematical Genomics, Department of Systems Biology, Columbia University, New York, NY 10032.; Department of Biomedical Informatics, Columbia University, New York, NY 10032.
Gautier J; Institute for Cancer Genetics, Vagelos College for Physicians and Surgeons, Columbia University, New York, NY 10032.; Department of Genetics and Development, Vagelos College for Physicians and Surgeons, Columbia University, New York, NY 10032.
Baer R; Institute for Cancer Genetics, Vagelos College for Physicians and Surgeons, Columbia University, New York, NY 10032.; Department of Pathology and Cell Biology, Herbert Irvine Comprehensive Cancer Center, Vagelos College for Physicians and Surgeons, Columbia University, New York, NY 10032.
Zha S; Institute for Cancer Genetics, Vagelos College for Physicians and Surgeons, Columbia University, New York, NY 10032; .; Department of Pathology and Cell Biology, Herbert Irvine Comprehensive Cancer Center, Vagelos College for Physicians and Surgeons, Columbia University, New York, NY 10032.; Division of Pediatric Hematology, Oncology, and Stem Cell Transplantation, Department of Pediatrics, Vagelos College for Physicians and Surgeons, Columbia University, New York, NY 10032.; Department of Immunology and Microbiology, Vagelos College for Physicians and Surgeons, Columbia University, New York, NY 10032.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Oct 13; Vol. 117 (41), pp. 25700-25711. Date of Electronic Publication: 2020 Sep 28.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA End-Joining Repair*
Immunoglobulin Class Switching*
Carrier Proteins/*metabolism
Cell Cycle Proteins/*metabolism
Immunoglobulin Heavy Chains/*genetics
Amino Acid Motifs ; Animals ; Ataxia Telangiectasia Mutated Proteins/genetics ; Ataxia Telangiectasia Mutated Proteins/metabolism ; B-Lymphocytes/metabolism ; Carrier Proteins/chemistry ; Carrier Proteins/genetics ; Cell Cycle Proteins/chemistry ; Cell Cycle Proteins/genetics ; Immunoglobulin Heavy Chains/metabolism ; Mice ; Phosphorylation ; Recombination, Genetic
Czasopismo naukowe
Tytuł :
Camel nanobodies: Promising molecular tools against leishmaniasis.
Autorzy :
Abu Alshamat E; Department of Animal Biology, Faculty of Sciences, Damascus University, Damascus, Syria.
Kweider M; Department of Animal Biology, Faculty of Sciences, Damascus University, Damascus, Syria.
Abbady AQ; Division of Molecular Biomedicine, Department of Molecular Biology and Biotechnology, AECS, Damascus, Syria.
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Źródło :
Parasite immunology [Parasite Immunol] 2020 Sep; Vol. 42 (9), pp. e12718. Date of Electronic Publication: 2020 Jul 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Leishmania tropica*/drug effects
Leishmania tropica*/growth & development
Leishmania tropica*/immunology
Camelus/*immunology
Immunoglobulin Heavy Chains/*therapeutic use
Leishmaniasis/*therapy
Single-Domain Antibodies/*therapeutic use
Animals ; Cells, Cultured ; Humans ; Immunoglobulin Heavy Chains/immunology ; Leishmaniasis/immunology ; Life Cycle Stages ; Macrophages/immunology ; Macrophages/parasitology ; Single-Domain Antibodies/immunology
Czasopismo naukowe
Tytuł :
Wapl repression by Pax5 promotes V gene recombination by Igh loop extrusion.
Autorzy :
Hill L; Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria.
Ebert A; Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria.
Jaritz M; Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria.
Wutz G; Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria.
Nagasaka K; Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria.
Tagoh H; Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria.; Ludwig Institute for Cancer Research, University of Oxford, Oxford, UK.
Kostanova-Poliakova D; Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria.
Schindler K; Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria.
Sun Q; Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria.
Bönelt P; Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria.
Fischer M; Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria.
Peters JM; Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria.
Busslinger M; Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria. .
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Źródło :
Nature [Nature] 2020 Aug; Vol. 584 (7819), pp. 142-147. Date of Electronic Publication: 2020 Jul 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genes, Immunoglobulin Heavy Chain/*genetics
Immunoglobulin Heavy Chains/*genetics
Immunoglobulin Variable Region/*genetics
PAX5 Transcription Factor/*metabolism
Proteins/*genetics
Repressor Proteins/*metabolism
V(D)J Recombination/*genetics
Animals ; B-Lymphocytes/cytology ; B-Lymphocytes/metabolism ; Binding Sites ; Cell Cycle Proteins/metabolism ; Chromatin Assembly and Disassembly ; Chromosomal Proteins, Non-Histone/metabolism ; Immunoglobulin Heavy Chains/chemistry ; Immunoglobulin Variable Region/chemistry ; Mice ; Polycomb Repressive Complex 2/metabolism ; Precursor Cells, B-Lymphoid/cytology ; Precursor Cells, B-Lymphoid/metabolism ; Promoter Regions, Genetic/genetics
Czasopismo naukowe
Tytuł :
Profiling the pattern of human TRB/IGH-CDR3 repertoire in liver transplantation patients via high-throughput sequencing analysis.
Autorzy :
Han FF; Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Fan H; Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Ren LL; Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Wang HG; Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Wang C; Stanford Genome Technology Center, Stanford University, Palo Alto, CA, USA.
Ma X; Department of Genetics, National Research Institute for Family Planning, Beijing, China.; Graduate School of Peking, Union Medical College, Beijing, China.
Liu LH; Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
He Q; Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Guo CL; Department of Genetics, National Research Institute for Family Planning, Beijing, China.; Graduate School of Peking, Union Medical College, Beijing, China.
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Źródło :
Scandinavian journal of immunology [Scand J Immunol] 2020 Aug; Vol. 92 (2), pp. e12912. Date of Electronic Publication: 2020 Jun 16.
Typ publikacji :
Journal Article
MeSH Terms :
Liver Transplantation*
Complementarity Determining Regions/*immunology
Graft Rejection/*immunology
Immunoglobulin Heavy Chains/*immunology
Receptors, Antigen, T-Cell, alpha-beta/*immunology
Adult ; Complementarity Determining Regions/genetics ; Female ; High-Throughput Nucleotide Sequencing ; Humans ; Immunoglobulin Heavy Chains/genetics ; Male ; Middle Aged ; Receptors, Antigen, T-Cell, alpha-beta/genetics
Czasopismo naukowe
Tytuł :
A single mutation increases heavy-chain heterodimer assembly of bispecific antibodies by inducing structural disorder in one homodimer species.
Autorzy :
Stutz C; Department of Antibody Engineering, Ichnos Sciences S.A., Biopôle Lausanne-Epalinges, Epalinges, Switzerland.
Blein S; Department of Antibody Engineering, Ichnos Sciences S.A., Biopôle Lausanne-Epalinges, Epalinges, Switzerland .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Jul 10; Vol. 295 (28), pp. 9392-9408. Date of Electronic Publication: 2020 May 13.
Typ publikacji :
Journal Article
MeSH Terms :
Antibodies, Bispecific*/chemistry
Antibodies, Bispecific*/genetics
Immunoglobulin Heavy Chains*/chemistry
Immunoglobulin Heavy Chains*/genetics
Mutation*
Protein Multimerization*
Single-Chain Antibodies*/chemistry
Single-Chain Antibodies*/genetics
Animals ; Humans
Czasopismo naukowe
Tytuł :
V H -V L interdomain dynamics observed by computer simulations and NMR.
Autorzy :
Fernández-Quintero ML; Institute of General, Inorganic and Theoretical Chemistry, and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain, Austria.
Hoerschinger VJ; Institute of General, Inorganic and Theoretical Chemistry, and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain, Austria.
Lamp LM; Institute of General, Inorganic and Theoretical Chemistry, and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain, Austria.
Bujotzek A; Roche Pharma Research and Early Development, Large Molecule Research, Roche Innovation Center Munich, Penzberg, Germany.
Georges G; Roche Pharma Research and Early Development, Large Molecule Research, Roche Innovation Center Munich, Penzberg, Germany.
Liedl KR; Institute of General, Inorganic and Theoretical Chemistry, and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain, Austria.
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Źródło :
Proteins [Proteins] 2020 Jul; Vol. 88 (7), pp. 830-839. Date of Electronic Publication: 2020 Jan 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunoglobulin Heavy Chains/*chemistry
Immunoglobulin Light Chains/*chemistry
Interleukin-1beta/*chemistry
Single-Chain Antibodies/*chemistry
Binding Sites ; Binding Sites, Antibody ; Humans ; Immunoglobulin Heavy Chains/metabolism ; Immunoglobulin Light Chains/metabolism ; Interleukin-1beta/metabolism ; Kinetics ; Molecular Dynamics Simulation ; Nuclear Magnetic Resonance, Biomolecular ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; Single-Chain Antibodies/metabolism ; Thermodynamics
Czasopismo naukowe
Tytuł :
Initial development of biosimilar immune checkpoint blockers using HEK293 cells.
Autorzy :
Ramos MB; Instituto de Tecnologia em Imunobiológicos (Bio-Manguinhos), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil.
Araújo AEV; Instituto de Tecnologia em Imunobiológicos (Bio-Manguinhos), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil.
Pestana CP; Instituto de Tecnologia em Imunobiológicos (Bio-Manguinhos), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil.
Ano Bom APD; Instituto de Tecnologia em Imunobiológicos (Bio-Manguinhos), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil.
Bastos RC; Instituto de Tecnologia em Imunobiológicos (Bio-Manguinhos), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil.
de Almeida Oliveira A; Instituto de Tecnologia em Imunobiológicos (Bio-Manguinhos), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil.
da Costa Neves PC; Instituto de Tecnologia em Imunobiológicos (Bio-Manguinhos), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil.
da Silva Junior HC; Instituto de Tecnologia em Imunobiológicos (Bio-Manguinhos), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil. Electronic address: .
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Źródło :
Protein expression and purification [Protein Expr Purif] 2020 Jun; Vol. 170, pp. 105596. Date of Electronic Publication: 2020 Feb 07.
Typ publikacji :
Journal Article
MeSH Terms :
Antibodies, Monoclonal/*pharmacology
Biosimilar Pharmaceuticals/*pharmacology
Immune Checkpoint Inhibitors/*pharmacology
Immune Checkpoint Proteins/*genetics
Immunoglobulin Heavy Chains/*pharmacology
Immunoglobulin Light Chains/*pharmacology
Antibodies, Monoclonal/biosynthesis ; Antibody Affinity ; Antibody Specificity ; Biosimilar Pharmaceuticals/metabolism ; Chromatography, Affinity ; Genetic Vectors/chemistry ; Genetic Vectors/metabolism ; HEK293 Cells ; Humans ; Immune Checkpoint Inhibitors/immunology ; Immune Checkpoint Proteins/immunology ; Immunoglobulin Heavy Chains/biosynthesis ; Immunoglobulin Light Chains/biosynthesis ; Isoelectric Focusing
Czasopismo naukowe
Tytuł :
Extreme genomic volatility characterizes the evolution of the immunoglobulin heavy chain locus in cyprinodontiform fishes.
Autorzy :
Bradshaw WJ; Max Planck Institute for Biology of Ageing, Joseph-Stelzmann-Str. 296, 50937 Cologne, Germany.; CECAD Research Center, University of Cologne, Joseph-Stelzmann-Str. 26, 50937 Cologne, Germany.
Valenzano DR; Max Planck Institute for Biology of Ageing, Joseph-Stelzmann-Str. 296, 50937 Cologne, Germany.; CECAD Research Center, University of Cologne, Joseph-Stelzmann-Str. 26, 50937 Cologne, Germany.
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Źródło :
Proceedings. Biological sciences [Proc Biol Sci] 2020 May 27; Vol. 287 (1927), pp. 20200489. Date of Electronic Publication: 2020 May 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Biological Evolution*
Cyprinodontiformes/*physiology
Immunoglobulin Heavy Chains/*genetics
Animals ; Cyprinodontiformes/genetics ; Genome ; Immunoglobulin Heavy Chains/immunology ; Phylogeny ; Volatilization
Czasopismo naukowe
Tytuł :
Murine gammaherpesvirus infection is skewed toward Igλ+ B cells expressing a specific heavy chain V-segment.
Autorzy :
Collins CM; Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America.
Scharer CD; Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America.
Murphy TJ; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia, United States of America.
Boss JM; Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America.
Speck SH; Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America.
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Źródło :
PLoS pathogens [PLoS Pathog] 2020 Apr 30; Vol. 16 (4), pp. e1008438. Date of Electronic Publication: 2020 Apr 30 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
B-Lymphocytes/*immunology
Gammaherpesvirinae/*physiology
Herpesviridae Infections/*veterinary
Immunoglobulin Heavy Chains/*immunology
Immunoglobulin Variable Region/*immunology
Immunoglobulin lambda-Chains/*immunology
Rodent Diseases/*immunology
Animals ; B-Lymphocytes/virology ; Female ; Gammaherpesvirinae/genetics ; Germinal Center/immunology ; Germinal Center/virology ; Herpesviridae Infections/genetics ; Herpesviridae Infections/immunology ; Herpesviridae Infections/virology ; Immunoglobulin Heavy Chains/genetics ; Immunoglobulin Variable Region/genetics ; Immunoglobulin lambda-Chains/genetics ; Mice ; Mice, Inbred C57BL ; Plasma Cells/immunology ; Plasma Cells/virology ; Receptors, Antigen, B-Cell/genetics ; Receptors, Antigen, B-Cell/immunology ; Rodent Diseases/genetics ; Rodent Diseases/virology
Czasopismo naukowe
Tytuł :
Novel strategy for expression and characterization of rabies virus glycoprotein.
Autorzy :
Zhao R; School of Life Sciences, Tsinghua University, Beijing, PR China; AnyGo Technology, Beijing, PR China.
Shan Y; Department of Emergency, The Sixth Medical Center of the General Hospital of the People's Liberation Army, Beijing, PR China.
Li M; AbMax Biotechnology, Beijing, PR China.
Lou Z; School of Life Sciences, Tsinghua University, Beijing, PR China.
Feng Y; Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun, PR China.
Huang L; Department of Emergency, The Sixth Medical Center of the General Hospital of the People's Liberation Army, Beijing, PR China.
Ren W; AbMax Biotechnology, Beijing, PR China.
Wang P; School of Life Sciences, Tsinghua University, Beijing, PR China.
Sun Y; AnyGo Technology, Beijing, PR China.
Sun Y; AnyGo Technology, Beijing, PR China.
Su J; AnyGo Technology, Beijing, PR China.
Sun H; AnyGo Technology, Beijing, PR China.
Hong D; AnyGo Technology, Beijing, PR China.
Li Y; Division of Arbovirus Vaccine, Institute for Biological Product Control, National Institutes for Food and Drug Control, Beijing, China.
Chen R; Department of Emergency, The Sixth Medical Center of the General Hospital of the People's Liberation Army, Beijing, PR China. Electronic address: .
Sun L; AnyGo Technology, Beijing, PR China; AbMax Biotechnology, Beijing, PR China. Electronic address: .
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Źródło :
Protein expression and purification [Protein Expr Purif] 2020 Apr; Vol. 168, pp. 105567. Date of Electronic Publication: 2020 Jan 03.
Typ publikacji :
Journal Article
MeSH Terms :
Antibodies, Neutralizing/*biosynthesis
Antibodies, Viral/*biosynthesis
Antigens, Viral/*administration & dosage
Immunoglobulin Heavy Chains/*genetics
Rabies/*prevention & control
Rabies virus/*immunology
Recombinant Fusion Proteins/*genetics
Viral Envelope Proteins/*administration & dosage
Animals ; Antigens, Viral/genetics ; Antigens, Viral/immunology ; Cloning, Molecular ; Cross Protection ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Gene Expression ; Genetic Vectors/chemistry ; Genetic Vectors/metabolism ; Humans ; Immune Sera/chemistry ; Immunoglobulin G/genetics ; Immunoglobulin G/metabolism ; Immunoglobulin Heavy Chains/metabolism ; Mice ; Protein Engineering/methods ; Protein Sorting Signals/genetics ; Rabies/virology ; Rabies Vaccines/administration & dosage ; Rabies Vaccines/biosynthesis ; Rabies Vaccines/genetics ; Rabies virus/genetics ; Recombinant Fusion Proteins/administration & dosage ; Recombinant Fusion Proteins/biosynthesis ; Viral Envelope Proteins/genetics ; Viral Envelope Proteins/immunology
Czasopismo naukowe
Tytuł :
Igh locus structure and evolution in Platyrrhines: new insights from a genomic perspective.
Autorzy :
Garzón-Ospina D; Pgame - Population Genetics And Molecular Evolution, Fundación Scient, Carrera 16-3 # 35-41, Tunja, Boyacá, Colombia. .
Buitrago SP; Pgame - Population Genetics And Molecular Evolution, Fundación Scient, Carrera 16-3 # 35-41, Tunja, Boyacá, Colombia. .
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Źródło :
Immunogenetics [Immunogenetics] 2020 Apr; Vol. 72 (3), pp. 165-179. Date of Electronic Publication: 2019 Dec 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunoglobulin Heavy Chains/*genetics
Platyrrhini/*genetics
Platyrrhini/*immunology
Animals ; Biological Evolution ; Evolution, Molecular ; Genome/genetics ; Genomics/methods ; Humans ; Immunoglobulin Heavy Chains/immunology ; Immunoglobulin Variable Region/genetics ; Phylogeny ; Primates/genetics ; Vertebrates/genetics
Czasopismo naukowe
Tytuł :
Genomic profiling of multiple myeloma: New insights and modern technologies.
Autorzy :
Hultcrantz M; Myeloma Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. Electronic address: .
Yellapantula V; Myeloma Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Rustad EH; Myeloma Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
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Źródło :
Best practice & research. Clinical haematology [Best Pract Res Clin Haematol] 2020 Mar; Vol. 33 (1), pp. 101153. Date of Electronic Publication: 2020 Jan 27.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Translocation, Genetic*
DNA, Neoplasm/*genetics
Genomics/*methods
High-Throughput Nucleotide Sequencing/*methods
Immunoglobulin Heavy Chains/*genetics
Multiple Myeloma/*diagnosis
Bone Marrow/immunology ; Bone Marrow/pathology ; DNA Copy Number Variations ; DNA, Neoplasm/immunology ; Disease Progression ; Genome, Human ; Humans ; Immunoglobulin Heavy Chains/immunology ; Multiple Myeloma/classification ; Multiple Myeloma/genetics ; Multiple Myeloma/immunology ; Mutation ; Neoplasm, Residual ; Plasma Cells/immunology ; Plasma Cells/pathology
Czasopismo naukowe
Tytuł :
Light Chains With Heavy Effects.
Autorzy :
Obici L; Amyloidosis Research and Treatment Centre, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Merlini G; Amyloidosis Research and Treatment Centre, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Department of Molecular Medicine, University of Pavia, Pavia, Italy. Electronic address: .
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Źródło :
American journal of kidney diseases : the official journal of the National Kidney Foundation [Am J Kidney Dis] 2020 Feb; Vol. 75 (2), pp. 291-293. Date of Electronic Publication: 2019 Oct 16.
Typ publikacji :
Editorial; Comment
MeSH Terms :
Immunoglobulin Heavy Chains*
Immunoglobulin Light Chains*
Humans ; Immunologic Tests
Opinia redakcyjna
Tytuł :
Applications of nanobodies in plant science and biotechnology.
Autorzy :
Wang W; Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, College of Life Sciences, South-Central University for Nationalities, Wuhan, Hubei, China. .; Precision Medicine R&D Center, Zhuhai Institute of Advanced Technology, Chinese Academy of Sciences, Zhuhai, Guangdong Province, China. .; Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong Province, China. .
Yuan J; Precision Medicine R&D Center, Zhuhai Institute of Advanced Technology, Chinese Academy of Sciences, Zhuhai, Guangdong Province, China.; Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong Province, China.
Jiang C; Precision Medicine R&D Center, Zhuhai Institute of Advanced Technology, Chinese Academy of Sciences, Zhuhai, Guangdong Province, China.; Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong Province, China.
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Źródło :
Plant molecular biology [Plant Mol Biol] 2021 Jan; Vol. 105 (1-2), pp. 43-53. Date of Electronic Publication: 2020 Oct 10.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Plants*
Single-Domain Antibodies*/chemistry
Single-Domain Antibodies*/immunology
Single-Domain Antibodies*/metabolism
Biotechnology/*methods
Nanotechnology/*methods
Epitopes ; Immunoglobulin Heavy Chains/classification ; Immunoglobulin Heavy Chains/metabolism
Czasopismo naukowe
Tytuł :
VHH characterization.Recombinant VHHs: Production, characterization and affinity.
Autorzy :
Chabrol E; PEX Biotechnologies, Chimie, Biologie, Institut de Recherches Servier, 125 Chemin de Ronde, 78290, Croissy-sur-Seine, France.
Stojko J; PEX Biotechnologies, Chimie, Biologie, Institut de Recherches Servier, 125 Chemin de Ronde, 78290, Croissy-sur-Seine, France.
Nicolas A; PEX Biotechnologies, Chimie, Biologie, Institut de Recherches Servier, 125 Chemin de Ronde, 78290, Croissy-sur-Seine, France.
Botzanowski T; Laboratoire de Spectrométrie de Masse BioOrganique, Université de Strasbourg, CNRS, IPHC, UMR 7178, 67000, Strasbourg, France.
Fould B; PEX Biotechnologies, Chimie, Biologie, Institut de Recherches Servier, 125 Chemin de Ronde, 78290, Croissy-sur-Seine, France.
Antoine M; PEX Biotechnologies, Chimie, Biologie, Institut de Recherches Servier, 125 Chemin de Ronde, 78290, Croissy-sur-Seine, France.
Cianférani S; Laboratoire de Spectrométrie de Masse BioOrganique, Université de Strasbourg, CNRS, IPHC, UMR 7178, 67000, Strasbourg, France.
Ferry G; PEX Biotechnologies, Chimie, Biologie, Institut de Recherches Servier, 125 Chemin de Ronde, 78290, Croissy-sur-Seine, France. Electronic address: .
Boutin JA; PEX Biotechnologies, Chimie, Biologie, Institut de Recherches Servier, 125 Chemin de Ronde, 78290, Croissy-sur-Seine, France; Institut de Recherches Internationales Servier, 50 rue Carnot, 92284, Suresnes Cedex, France. Electronic address: .
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Źródło :
Analytical biochemistry [Anal Biochem] 2020 Jan 15; Vol. 589, pp. 113491. Date of Electronic Publication: 2019 Oct 30.
Typ publikacji :
Journal Article
MeSH Terms :
Immunoglobulin Heavy Chains*/chemistry
Immunoglobulin Heavy Chains*/isolation & purification
Single-Domain Antibodies*/chemistry
Single-Domain Antibodies*/isolation & purification
Camelids, New World/*immunology
Receptor, ErbB-2/*immunology
Serum Albumin, Human/*immunology
Animals ; Antigens/immunology ; Cloning, Molecular ; ErbB Receptors/immunology ; Escherichia coli/genetics ; Humans ; Recombinant Proteins/immunology
Czasopismo naukowe
Tytuł :
A Proposed New Nomenclature for the Immunoglobulin Genes of Mus musculus .
Autorzy :
Busse CE; Division of B Cell Immunology, German Cancer Research Center, Heidelberg, Germany.
Jackson KJL; Immunology Division, The Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.
Watson CT; Department of Biochemistry and Molecular Genetics, University of Louisville, Louisville, KY, United States.
Collins AM; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia.
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Źródło :
Frontiers in immunology [Front Immunol] 2019 Dec 18; Vol. 10, pp. 2961. Date of Electronic Publication: 2019 Dec 18 (Print Publication: 2019).
Typ publikacji :
Journal Article
MeSH Terms :
Alleles*
Genes, Immunoglobulin*
Genetic Loci*
Immunoglobulin Heavy Chains*/classification
Immunoglobulin Heavy Chains*/genetics
Immunoglobulin kappa-Chains*/classification
Immunoglobulin kappa-Chains*/genetics
Animals ; Mice ; Terminology as Topic
Czasopismo naukowe
Tytuł :
Characterization of the internal translation initiation region in monoclonal antibodies expressed in Escherichia coli .
Autorzy :
Leith EM; Biomolecular Labeling Laboratory, National Institute of Standards and Technology and Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, Maryland 20850.
O'Dell WB; Biomolecular Labeling Laboratory, National Institute of Standards and Technology and Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, Maryland 20850.; National Institute of Standards and Technology, Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, Maryland 20850.
Ke N; New England Biolabs, Ipswich, Massachusetts 01938.
McClung C; New England Biolabs, Ipswich, Massachusetts 01938.
Berkmen M; New England Biolabs, Ipswich, Massachusetts 01938.
Bergonzo C; National Institute of Standards and Technology, Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, Maryland 20850.
Brinson RG; National Institute of Standards and Technology, Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, Maryland 20850.
Kelman Z; Biomolecular Labeling Laboratory, National Institute of Standards and Technology and Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, Maryland 20850 .; National Institute of Standards and Technology, Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, Maryland 20850.
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2019 Nov 29; Vol. 294 (48), pp. 18046-18056. Date of Electronic Publication: 2019 Oct 11.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Adalimumab*/biosynthesis
Adalimumab*/genetics
Escherichia coli*/genetics
Escherichia coli*/metabolism
Immunoglobulin Heavy Chains*/biosynthesis
Immunoglobulin Heavy Chains*/genetics
Peptide Chain Initiation, Translational*
Recombinant Proteins/biosynthesis ; Recombinant Proteins/genetics
Czasopismo naukowe
Tytuł :
Identification and characterization of an IgG sequence variant with an 11 kDa heavy chain C-terminal extension using a combination of mass spectrometry and high-throughput sequencing analysis.
Autorzy :
Harris C; Biopharmaceutical Development, BioPharmaceuticals R&D, AstraZeneca , Cambridge , UK.
Xu W; Biopharmaceutical Development, BioPharmaceuticals R&D, AstraZeneca , Gaithersburg , MD , USA.
Grassi L; Biopharmaceutical Development, BioPharmaceuticals R&D, AstraZeneca , Cambridge , UK.
Wang C; Biopharmaceutical Development, BioPharmaceuticals R&D, AstraZeneca , Gaithersburg , MD , USA.
Markle A; Biopharmaceutical Development, BioPharmaceuticals R&D, AstraZeneca , Gaithersburg , MD , USA.
Hardman C; Data Science & Artificial Intelligence, BioPharmaceuticals R&D, AstraZeneca , Cambridge , UK.
Stevens R; Antibody Discovery and Protein Engineering, BioPharmaceuticals R&D, AstraZeneca , Cambridge , UK.
Miro-Quesada G; Data & Quantitative Sciences, Biopharmaceutical Development, BioPharmaceuticals R&D, AstraZeneca , Gaithersburg , MD , USA.
Hatton D; Biopharmaceutical Development, BioPharmaceuticals R&D, AstraZeneca , Cambridge , UK.
Wang J; Biopharmaceutical Development, BioPharmaceuticals R&D, AstraZeneca , Gaithersburg , MD , USA.
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Źródło :
MAbs [MAbs] 2019 Nov-Dec; Vol. 11 (8), pp. 1452-1463. Date of Electronic Publication: 2019 Oct 01.
Typ publikacji :
Journal Article
MeSH Terms :
Antibodies, Monoclonal*/chemistry
Antibodies, Monoclonal*/genetics
Antibodies, Monoclonal*/immunology
Immunoglobulin G*/chemistry
Immunoglobulin G*/genetics
Immunoglobulin G*/immunology
Immunoglobulin Heavy Chains*/chemistry
Immunoglobulin Heavy Chains*/genetics
Immunoglobulin Heavy Chains*/immunology
Animals ; CHO Cells ; Chromatography, Liquid ; Cricetulus ; High-Throughput Nucleotide Sequencing ; Mice ; Protein Domains ; Tandem Mass Spectrometry
Czasopismo naukowe

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