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Wyszukujesz frazę ""Immunoglobulin Heavy Chains"" wg kryterium: Temat


Tytuł:
The immunoglobulin heavy chain super enhancer controls class switch recombination in developing B cells.
Autorzy:
Dauba A; Institut de Pharmacologie Et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Université Toulouse III - Paul Sabatier (UT3), CNRS UMR5089, 205 Route de Narbonne, BP 64182, 31077, Toulouse, France.
Näser E; Institut de Pharmacologie Et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Université Toulouse III - Paul Sabatier (UT3), CNRS UMR5089, 205 Route de Narbonne, BP 64182, 31077, Toulouse, France.
Andrieux D; Institut de Pharmacologie Et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Université Toulouse III - Paul Sabatier (UT3), CNRS UMR5089, 205 Route de Narbonne, BP 64182, 31077, Toulouse, France.
Cogné M; MOBIDIC, INSERM U1236, Université de Rennes 1, Rennes, France.
Denizot Y; UMR CNRS 7276, INSERM U1262, Université de Limoges, CBRS, Limoges, France.
Khamlichi AA; Institut de Pharmacologie Et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Université Toulouse III - Paul Sabatier (UT3), CNRS UMR5089, 205 Route de Narbonne, BP 64182, 31077, Toulouse, France. .
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Źródło:
Scientific reports [Sci Rep] 2024 Mar 28; Vol. 14 (1), pp. 7370. Date of Electronic Publication: 2024 Mar 28.
Typ publikacji:
Journal Article
MeSH Terms:
Immunoglobulin Heavy Chains*/genetics
Super Enhancers*
Regulatory Sequences, Nucleic Acid/genetics ; Immunoglobulin Class Switching/genetics ; B-Lymphocytes ; Immunoglobulin Isotypes/genetics ; Enhancer Elements, Genetic
Czasopismo naukowe
Tytuł:
Antibody production relies on the tRNA inosine wobble modification to meet biased codon demand.
Autorzy:
Giguère S; The Ragon Institute of Mass General, Massachusetts Institute of Technology (MIT), and Harvard, Cambridge, MA 02139, USA.
Wang X; The Ragon Institute of Mass General, Massachusetts Institute of Technology (MIT), and Harvard, Cambridge, MA 02139, USA.
Huber S; Department of Biological Engineering, MIT, Cambridge, MA 02139, USA.
Xu L; The Ragon Institute of Mass General, Massachusetts Institute of Technology (MIT), and Harvard, Cambridge, MA 02139, USA.
Warner J; The Ragon Institute of Mass General, Massachusetts Institute of Technology (MIT), and Harvard, Cambridge, MA 02139, USA.
Weldon SR; The Ragon Institute of Mass General, Massachusetts Institute of Technology (MIT), and Harvard, Cambridge, MA 02139, USA.
Hu J; Department of Biological Engineering, MIT, Cambridge, MA 02139, USA.
Phan QA; The Ragon Institute of Mass General, Massachusetts Institute of Technology (MIT), and Harvard, Cambridge, MA 02139, USA.
Tumang K; The Ragon Institute of Mass General, Massachusetts Institute of Technology (MIT), and Harvard, Cambridge, MA 02139, USA.
Prum T; The Ragon Institute of Mass General, Massachusetts Institute of Technology (MIT), and Harvard, Cambridge, MA 02139, USA.
Ma D; BioMicro Center, MIT, Cambridge, MA 02139, USA.
Kirsch KH; The Ragon Institute of Mass General, Massachusetts Institute of Technology (MIT), and Harvard, Cambridge, MA 02139, USA.
Nair U; The Ragon Institute of Mass General, Massachusetts Institute of Technology (MIT), and Harvard, Cambridge, MA 02139, USA.
Dedon P; Department of Biological Engineering, MIT, Cambridge, MA 02139, USA.; Singapore-MIT Alliance for Research and Technology, Singapore 138602.
Batista FD; The Ragon Institute of Mass General, Massachusetts Institute of Technology (MIT), and Harvard, Cambridge, MA 02139, USA.; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA.; Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA.; Department of Biology, MIT, Cambridge, MA 02139, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2024 Jan 12; Vol. 383 (6679), pp. 205-211. Date of Electronic Publication: 2024 Jan 11.
Typ publikacji:
Journal Article
MeSH Terms:
Antibody Formation*/genetics
Codon Usage*
Inosine*/genetics
Inosine*/metabolism
RNA, Transfer*/genetics
Antibodies*/genetics
B-Lymphocytes*/immunology
Immunoglobulin Heavy Chains*/genetics
Codon/genetics ; Humans
Czasopismo naukowe
Tytuł:
Evaluation of the Potential Impact of In Silico Humanization on V H H Dynamics.
Autorzy:
Martins C; Université Paris Cité and Université de la Réunion and Université des Antilles, INSERM, BIGR, DSIMB, F-75014 Paris, France.; Université Paris Cité and Université de la Réunion and Université des Antilles, INSERM, BIGR, DSIMB, F-97715 Saint Denis Messag, France.
Diharce J; Université Paris Cité and Université de la Réunion and Université des Antilles, INSERM, BIGR, DSIMB, F-75014 Paris, France.
Nadaradjane AA; Université Paris Cité and Université de la Réunion and Université des Antilles, INSERM, BIGR, DSIMB, F-97715 Saint Denis Messag, France.
de Brevern AG; Université Paris Cité and Université de la Réunion and Université des Antilles, INSERM, BIGR, DSIMB, F-75014 Paris, France.; Université Paris Cité and Université de la Réunion and Université des Antilles, INSERM, BIGR, DSIMB, F-97715 Saint Denis Messag, France.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Sep 26; Vol. 24 (19). Date of Electronic Publication: 2023 Sep 26.
Typ publikacji:
Journal Article
MeSH Terms:
Immunoglobulin Heavy Chains*/chemistry
Camelids, New World*
Humans ; Animals ; Antibodies ; Biotechnology
Czasopismo naukowe
Tytuł:
A Novel Strategy for Screening Tumor-Specific Variable Domain of Heavy-Chain Antibodies.
Autorzy:
Rafique A; Graduate School of Science and Engineering, University of Kagoshima, Kagoshima 890-0065, Japan.
Hichiwa G; Graduate School of Medical Sciences, Tottori University, Tottori 680-8550, Japan.
Jatnika MF; Graduate School of Science and Engineering, University of Kagoshima, Kagoshima 890-0065, Japan.
Ito Y; Graduate School of Science and Engineering, University of Kagoshima, Kagoshima 890-0065, Japan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jun 28; Vol. 24 (13). Date of Electronic Publication: 2023 Jun 28.
Typ publikacji:
Journal Article
MeSH Terms:
Immunoglobulin Heavy Chains*/genetics
Antibodies, Monoclonal*
Phylogeny ; Cell Line, Tumor ; Gene Library ; Peptide Library
Czasopismo naukowe
Tytuł:
Germline-encoded amino acid-binding motifs drive immunodominant public antibody responses.
Autorzy:
Shrock EL; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.; Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA.; Program in Biological and Biomedical Sciences, Harvard University, Boston, MA 02115, USA.
Timms RT; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK.
Kula T; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.; Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA.; Program in Biological and Biomedical Sciences, Harvard University, Boston, MA 02115, USA.
Mena EL; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.; Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA.
West AP Jr; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Guo R; Division of Infectious Disease, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA.
Lee IH; Center for Systems Biology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Cohen AA; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
McKay LGA; National Emerging Infectious Diseases Laboratories, Boston University School of Medicine, Boston University, Boston, MA 02118, USA.
Bi C; Division of Allergy and Immunology, Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Massachusetts Consortium on Pathogen Readiness, Boston, MA 02115, USA.
Leng Y; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.; Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA.
Fujimura E; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.; Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA.
Horns F; Department of Bioengineering, Department of Applied Physics, Chan Zuckerberg Biohub and Stanford University, Stanford, CA 94305, USA.
Li M; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.; Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA.
Wesemann DR; Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA.; Division of Allergy and Immunology, Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Massachusetts Consortium on Pathogen Readiness, Boston, MA 02115, USA.; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, 02139 USA.
Griffiths A; National Emerging Infectious Diseases Laboratories, Boston University School of Medicine, Boston University, Boston, MA 02118, USA.
Gewurz BE; Division of Infectious Disease, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA.; Graduate Program in Virology, Division of Medical Sciences, Harvard Medical School, Boston, MA 02115, USA.
Bjorkman PJ; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Elledge SJ; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.; Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2023 Apr 07; Vol. 380 (6640), pp. eadc9498. Date of Electronic Publication: 2023 Apr 07.
Typ publikacji:
Journal Article
MeSH Terms:
Antibody Formation*
Immunodominant Epitopes*/chemistry
Immunodominant Epitopes*/genetics
Immunoglobulin Heavy Chains*/genetics
Immunoglobulin Heavy Chains*/immunology
Amino Acid Motifs*
Immunoglobulin Light Chains*/genetics
Immunoglobulin Light Chains*/immunology
Host-Pathogen Interactions*/genetics
Host-Pathogen Interactions*/immunology
Animals ; Humans ; Mice ; Germ Cells ; Epitope Mapping
Czasopismo naukowe
Tytuł:
Vaccination induces HIV broadly neutralizing antibody precursors in humans.
Autorzy:
Leggat DJ; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Cohen KW; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Willis JR; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Fulp WJ; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
deCamp AC; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Kalyuzhniy O; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Cottrell CA; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Menis S; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Finak G; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Ballweber-Fleming L; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Srikanth A; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Plyler JR; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Schiffner T; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Liguori A; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Rahaman F; IAVI, New York, NY 10004, USA.
Lombardo A; IAVI, New York, NY 10004, USA.
Philiponis V; IAVI, New York, NY 10004, USA.
Whaley RE; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Seese A; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Brand J; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Ruppel AM; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Hoyland W; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Yates NL; Center for Human Systems Immunology, Departments of Surgery, Immunology, Molecular Genetics and Microbiology, Duke University, Durham, NC 27701, USA.
Williams LD; Center for Human Systems Immunology, Departments of Surgery, Immunology, Molecular Genetics and Microbiology, Duke University, Durham, NC 27701, USA.
Greene K; Duke University Medical Center, Durham, NC 27701, USA.
Gao H; Duke University Medical Center, Durham, NC 27701, USA.
Mahoney CR; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Corcoran MM; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
Cagigi A; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Taylor A; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Brown DM; The Foundation for the National Institutes of Health, North Bethesda, MD 20852, USA.
Ambrozak DR; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Sincomb T; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Hu X; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Tingle R; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Georgeson E; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Eskandarzadeh S; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Alavi N; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Lu D; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Mullen TM; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Kubitz M; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Groschel B; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Maenza J; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.; Department of Medicine, University of Washington, Seattle, WA 98195, USA.
Kolokythas O; Department of Radiology, University of Washington, Seattle, WA 98195, USA.
Khati N; Department of Radiology, School of Medicine and Health Sciences, The George Washington University, Washington, DC 20037, USA.
Bethony J; Department of Microbiology, Immunology and Tropical Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, DC 20037, USA.
Crotty S; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego, La Jolla, CA 92037, USA.
Roederer M; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Karlsson Hedestam GB; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, SE-171 77 Stockholm, Sweden.; Department of Medicine, University of Washington, Seattle, WA 98195, USA.
Tomaras GD; Center for Human Systems Immunology, Departments of Surgery, Immunology, Molecular Genetics and Microbiology, Duke University, Durham, NC 27701, USA.
Montefiori D; Duke University Medical Center, Durham, NC 27701, USA.
Diemert D; Department of Microbiology, Immunology and Tropical Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, DC 20037, USA.; Department of Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, DC 20052, USA.
Koup RA; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Laufer DS; IAVI, New York, NY 10004, USA.
McElrath MJ; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.; Department of Medicine, University of Washington, Seattle, WA 98195, USA.
McDermott AB; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Schief WR; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.; The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2022 Dec 02; Vol. 378 (6623), pp. eadd6502. Date of Electronic Publication: 2022 Dec 02.
Typ publikacji:
Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
AIDS Vaccines*/immunology
Broadly Neutralizing Antibodies*/genetics
Broadly Neutralizing Antibodies*/immunology
HIV Infections*/prevention & control
HIV Antibodies*/genetics
HIV Antibodies*/immunology
Germ Cells*/immunology
Immunoglobulin Light Chains*/genetics
Immunoglobulin Light Chains*/immunology
Immunoglobulin Heavy Chains*/genetics
Immunoglobulin Heavy Chains*/immunology
Humans ; Adjuvants, Immunologic ; Vaccination ; B-Lymphocytes/immunology ; Mutation ; Male ; Female ; Adult
Czasopismo naukowe
Tytuł:
Enteric pharmacokinetics of monomeric and multimeric camelid nanobody single-domain antibodies.
Autorzy:
Debatis M; Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, United States of America.
Danz H; Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, United States of America.
Tremblay JM; Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, United States of America.
Gaspie K; Division of Animal Resources, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, United States of America.
Kudej RK; Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, United States of America.
Vigdorovich V; Center for Global Infectious Disease Research, Seattle Children's Hospital, Seattle, WA, United States of America.
Sather N; Center for Global Infectious Disease Research, Seattle Children's Hospital, Seattle, WA, United States of America.
Jaskiewicz JJ; Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, United States of America.
Tzipori S; Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, United States of America.
Shoemaker CB; Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, United States of America.
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Źródło:
PloS one [PLoS One] 2023 Nov 27; Vol. 18 (11), pp. e0291937. Date of Electronic Publication: 2023 Nov 27 (Print Publication: 2023).
Typ publikacji:
Journal Article
MeSH Terms:
Single-Domain Antibodies*
Camelids, New World*
Animals ; Humans ; Rabbits ; Swine ; Immunoglobulin Heavy Chains ; Antibodies, Monoclonal ; Amino Acid Sequence ; Peptide Hydrolases
Czasopismo naukowe
Tytuł:
Replication timing and genetic instability.
Autorzy:
Méchali M; Institute of Human Genetics, CNRS-University of Montpellier, Montpellier, France.
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Źródło:
Science (New York, N.Y.) [Science] 2022 Sep 16; Vol. 377 (6612), pp. 1259-1260. Date of Electronic Publication: 2022 Sep 15.
Typ publikacji:
Journal Article; Comment
MeSH Terms:
DNA Replication Timing*
Genomic Instability*
Immunoglobulin Heavy Chains*/genetics
Lymphoma, B-Cell*/genetics
Proto-Oncogene Proteins c-myc*/genetics
Replication Origin*
Translocation, Genetic*
Humans
Czasopismo naukowe
Tytuł:
Homozygous iMycCα transgenic mice as a model of plasma B-cell lymphomas.
Autorzy:
Ferrad M; UMR CNRS 7276, INSERM U1262, Equipe Labellisée LIGUE 2018, Université de Limoges, Limoges, France.
Ghazzaui N; UMR CNRS 7276, INSERM U1262, Equipe Labellisée LIGUE 2018, Université de Limoges, Limoges, France.
Issaoui H; UMR CNRS 7276, INSERM U1262, Equipe Labellisée LIGUE 2018, Université de Limoges, Limoges, France.
Drouineau E; I2BC, IBITEC-S, CEA, CNRS, Université Paris-Sud, Université Paris-Saclay, Gif-sur-Yvette, France.
Oblet C; UMR CNRS 7276, INSERM U1262, Equipe Labellisée LIGUE 2018, Université de Limoges, Limoges, France.
Marchiol T; UMR CNRS 7276, INSERM U1262, Equipe Labellisée LIGUE 2018, Université de Limoges, Limoges, France.
Cook-Moreau J; UMR CNRS 7276, INSERM U1262, Equipe Labellisée LIGUE 2018, Université de Limoges, Limoges, France.
Denizot Y; UMR CNRS 7276, INSERM U1262, Equipe Labellisée LIGUE 2018, Université de Limoges, Limoges, France.
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Źródło:
Leukemia & lymphoma [Leuk Lymphoma] 2022 Sep; Vol. 63 (9), pp. 2114-2125. Date of Electronic Publication: 2022 Apr 28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Immunoglobulin Heavy Chains*/genetics
Lymphoma, B-Cell*/genetics
Lymphoma, B-Cell*/pathology
Animals ; B-Lymphocytes/pathology ; Disease Models, Animal ; Humans ; Mice ; Mice, Transgenic ; Regulatory Sequences, Nucleic Acid
Czasopismo naukowe
Tytuł:
CD34+ cell of origin for immunoglobulin heavy chain variable region unmutated, but not mutated, chronic lymphocytic leukemia.
Autorzy:
Perkins B; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, John Hopkins University, Baltimore, MD, USA.
Showel M; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, John Hopkins University, Baltimore, MD, USA.
Schoch L; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, John Hopkins University, Baltimore, MD, USA.
Imus PH; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, John Hopkins University, Baltimore, MD, USA.
Karantanos T; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, John Hopkins University, Baltimore, MD, USA.
Yonescu R; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, John Hopkins University, Baltimore, MD, USA.
Morsberger L; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, John Hopkins University, Baltimore, MD, USA.
Ghiaur G; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, John Hopkins University, Baltimore, MD, USA.
Gladstone DE; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, John Hopkins University, Baltimore, MD, USA.
Jones RJ; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, John Hopkins University, Baltimore, MD, USA.
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Źródło:
Leukemia & lymphoma [Leuk Lymphoma] 2022 Jul; Vol. 63 (7), pp. 1617-1623. Date of Electronic Publication: 2022 Mar 27.
Typ publikacji:
Journal Article
MeSH Terms:
Immunoglobulin Heavy Chains*/genetics
Leukemia, Lymphocytic, Chronic, B-Cell*/genetics
Mutation*
Precursor Cells, B-Lymphoid*/immunology
Animals ; Antigens, CD19 ; Antigens, CD34 ; Chromosome Aberrations ; Flow Cytometry ; Heterografts ; Humans ; Mice ; Prognosis
Czasopismo naukowe
Tytuł:
Learning the statistics and landscape of somatic mutation-induced insertions and deletions in antibodies.
Autorzy:
Lupo C; Laboratoire de physique de l'École normale supérieure, CNRS, PSL University, Sorbonne Université, and Université de Paris, Paris, France.
Spisak N; Laboratoire de physique de l'École normale supérieure, CNRS, PSL University, Sorbonne Université, and Université de Paris, Paris, France.
Walczak AM; Laboratoire de physique de l'École normale supérieure, CNRS, PSL University, Sorbonne Université, and Université de Paris, Paris, France.
Mora T; Laboratoire de physique de l'École normale supérieure, CNRS, PSL University, Sorbonne Université, and Université de Paris, Paris, France.
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Źródło:
PLoS computational biology [PLoS Comput Biol] 2022 Jun 02; Vol. 18 (6), pp. e1010167. Date of Electronic Publication: 2022 Jun 02 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Genes, Immunoglobulin*
Immunoglobulin Heavy Chains*/genetics
Antibodies/genetics ; Humans ; INDEL Mutation/genetics ; Mutation
Czasopismo naukowe
Tytuł:
NANOBODY Molecule, a Giga Medical Tool in Nanodimensions.
Autorzy:
Kunz S; Université Côte d'Azur, CNRS UMR7284, INSERM U1081, IRCAN, 06107 Nice, France.; Department of Oncology, Sanofi Research Center, 94400 Vitry-sur-Seine, France.
Durandy M; Université Côte d'Azur, CNRS UMR7284, INSERM U1081, IRCAN, 06107 Nice, France.
Seguin L; Université Côte d'Azur, CNRS UMR7284, INSERM U1081, IRCAN, 06107 Nice, France.
Feral CC; Université Côte d'Azur, CNRS UMR7284, INSERM U1081, IRCAN, 06107 Nice, France.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Aug 25; Vol. 24 (17). Date of Electronic Publication: 2023 Aug 25.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Antibodies, Monoclonal*/therapeutic use
Biomedical Research*
Excipients ; Fluorescent Dyes ; Immunoglobulin Fab Fragments ; Immunoglobulin Heavy Chains
Czasopismo naukowe
Tytuł:
VHH CDR-H3 conformation is determined by VH germline usage.
Autorzy:
Bahrami Dizicheh Z; 23andMe, Inc. Therapeutics, 349 Oyster Point Boulevard, South San Francisco, CA, 94080, USA.
Chen IL; 23andMe, Inc. Therapeutics, 349 Oyster Point Boulevard, South San Francisco, CA, 94080, USA.
Koenig P; 23andMe, Inc. Therapeutics, 349 Oyster Point Boulevard, South San Francisco, CA, 94080, USA. .
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Źródło:
Communications biology [Commun Biol] 2023 Aug 19; Vol. 6 (1), pp. 864. Date of Electronic Publication: 2023 Aug 19.
Typ publikacji:
Journal Article
MeSH Terms:
Camelids, New World*
Animals ; Antibodies ; Germ Cells ; Immunoglobulin Heavy Chains ; Lymphocyte Activation
Czasopismo naukowe
Tytuł:
V H H Structural Modelling Approaches: A Critical Review.
Autorzy:
Vishwakarma P; INSERM UMR_S 1134, BIGR, DSIMB Team, Université de Paris and Université de la Réunion, F-75015 Paris, France.; INSERM UMR_S 1134, BIGR, DSIMB Team, Université de Paris and Université de la Réunion, F-97715 Saint Denis Messag, France.
Vattekatte AM; INSERM UMR_S 1134, BIGR, DSIMB Team, Université de Paris and Université de la Réunion, F-75015 Paris, France.; INSERM UMR_S 1134, BIGR, DSIMB Team, Université de Paris and Université de la Réunion, F-97715 Saint Denis Messag, France.
Shinada N; 3 SBX Corp., Tokyo-to, Shinagawa-ku, Tokyo 141-0022, Japan.
Diharce J; INSERM UMR_S 1134, BIGR, DSIMB Team, Université de Paris and Université de la Réunion, F-75015 Paris, France.
Martins C; INSERM UMR_S 1134, BIGR, DSIMB Team, Université de Paris and Université de la Réunion, F-75015 Paris, France.; INSERM UMR_S 1134, BIGR, DSIMB Team, Université de Paris and Université de la Réunion, F-97715 Saint Denis Messag, France.
Cadet F; INSERM UMR_S 1134, BIGR, DSIMB Team, Université de Paris and Université de la Réunion, F-97715 Saint Denis Messag, France.; PEACCEL, Artificial Intelligence Department, Square Albin Cachot, F-75013 Paris, France.
Gardebien F; INSERM UMR_S 1134, BIGR, DSIMB Team, Université de Paris and Université de la Réunion, F-97715 Saint Denis Messag, France.
Etchebest C; INSERM UMR_S 1134, BIGR, DSIMB Team, Université de Paris and Université de la Réunion, F-75015 Paris, France.
Nadaradjane AA; INSERM UMR_S 1134, BIGR, DSIMB Team, Université de Paris and Université de la Réunion, F-75015 Paris, France.; INSERM UMR_S 1134, BIGR, DSIMB Team, Université de Paris and Université de la Réunion, F-97715 Saint Denis Messag, France.
de Brevern AG; INSERM UMR_S 1134, BIGR, DSIMB Team, Université de Paris and Université de la Réunion, F-75015 Paris, France.; INSERM UMR_S 1134, BIGR, DSIMB Team, Université de Paris and Université de la Réunion, F-97715 Saint Denis Messag, France.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Mar 28; Vol. 23 (7). Date of Electronic Publication: 2022 Mar 28.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Camelids, New World*
Immunoglobulin Heavy Chains*/chemistry
Amino Acid Sequence ; Animals ; Antibodies ; Models, Structural
Czasopismo naukowe
Tytuł:
Easily Established and Multifunctional Synthetic Nanobody Libraries as Research Tools.
Autorzy:
Liu B; Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543, Singapore.
Yang D; Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543, Singapore.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Jan 27; Vol. 23 (3). Date of Electronic Publication: 2022 Jan 27.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Peptide Library*
Immunoglobulin Heavy Chains/*chemistry
Single-Domain Antibodies/*chemistry
Animals ; Antigens/chemistry ; Antigens/genetics ; Antigens/immunology ; Camelus ; Chromatography, Affinity ; Immunoglobulin Heavy Chains/genetics ; Immunoglobulin Heavy Chains/immunology ; Single-Domain Antibodies/genetics ; Single-Domain Antibodies/immunology
Czasopismo naukowe
Tytuł:
Liquid biopsy-based monitoring of residual disease in multiple myeloma by analysis of the rearranged immunoglobulin genes-A feasibility study.
Autorzy:
Marx A; Department of Immunology, Institute of Biology, ELTE Eötvös Loránd University, Budapest, Hungary.; Doctoral School of Biology, ELTE Eötvös Loránd University, Budapest, Hungary.
Osváth M; Department of Immunology, Institute of Biology, ELTE Eötvös Loránd University, Budapest, Hungary.; Doctoral School of Biology, ELTE Eötvös Loránd University, Budapest, Hungary.
Szikora B; Department of Immunology, Institute of Biology, ELTE Eötvös Loránd University, Budapest, Hungary.
Pipek O; Department of Physics of Complex Systems, ELTE Eötvös Loránd University, Budapest, Hungary.
Csabai I; Department of Physics of Complex Systems, ELTE Eötvös Loránd University, Budapest, Hungary.
Nagy Á; Department of Pathology and Experimental Cancer Research, HCEMM-SE Molecular Oncohematology Research Group, Semmelweis University, Budapest, Hungary.
Bödör C; Department of Pathology and Experimental Cancer Research, HCEMM-SE Molecular Oncohematology Research Group, Semmelweis University, Budapest, Hungary.
Matula Z; National Institute of Hematology and Infectious Diseases, Central Hospital of Southern Pest, Budapest, Hungary.
Nagy G; National Institute of Hematology and Infectious Diseases, Central Hospital of Southern Pest, Budapest, Hungary.
Bors A; National Institute of Hematology and Infectious Diseases, Central Hospital of Southern Pest, Budapest, Hungary.
Uher F; National Institute of Hematology and Infectious Diseases, Central Hospital of Southern Pest, Budapest, Hungary.
Mikala G; National Institute of Hematology and Infectious Diseases, Central Hospital of Southern Pest, Budapest, Hungary.
Vályi-Nagy I; National Institute of Hematology and Infectious Diseases, Central Hospital of Southern Pest, Budapest, Hungary.
Kacskovics I; Department of Immunology, Institute of Biology, ELTE Eötvös Loránd University, Budapest, Hungary.
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Źródło:
PloS one [PLoS One] 2023 May 26; Vol. 18 (5), pp. e0285696. Date of Electronic Publication: 2023 May 26 (Print Publication: 2023).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Genes, Immunoglobulin*
Multiple Myeloma*/diagnosis
Multiple Myeloma*/genetics
Humans ; Feasibility Studies ; Reproducibility of Results ; Translocation, Genetic ; Immunoglobulin Heavy Chains/genetics ; Neoplasm, Residual/diagnosis ; Neoplasm, Residual/genetics ; Neoplasm, Residual/pathology
Czasopismo naukowe
Tytuł:
Structure of Nanobody Nb23.
Autorzy:
Percipalle M; Science Division, New York University Abu Dhabi, Abu Dhabi 129188, United Arab Emirates.; Department of Chemistry and Magnetic Resonance Center, University of Florence, 50019 Florence, Italy.
Hunashal Y; Science Division, New York University Abu Dhabi, Abu Dhabi 129188, United Arab Emirates.
Steyaert J; Structural Biology Brussels, Vrije Universiteit Brussel, B-1050 Brussels, Belgium.; VIB-VUB Center for Structural Biology, Vlaams Instituut voor Biotechnologie, B-1050 Brussels, Belgium.
Fogolari F; Dipartimento di Scienze Matematiche, Informatiche, e Fisiche, Udine University, 33100 Udine, Italy.; Istituto Nazionale Biostrutture e Biosistemi, 00136 Roma, Italy.
Esposito G; Science Division, New York University Abu Dhabi, Abu Dhabi 129188, United Arab Emirates.; Istituto Nazionale Biostrutture e Biosistemi, 00136 Roma, Italy.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2021 Jun 11; Vol. 26 (12). Date of Electronic Publication: 2021 Jun 11.
Typ publikacji:
Journal Article
MeSH Terms:
Antibodies, Monoclonal/*chemistry
Immunoglobulin Heavy Chains/*chemistry
Magnetic Resonance Spectroscopy/*methods
Nuclear Magnetic Resonance, Biomolecular/*methods
Single-Domain Antibodies/*chemistry
beta 2-Microglobulin/*metabolism
Antibodies, Monoclonal/immunology ; Antibodies, Monoclonal/metabolism ; Humans ; Immunoglobulin Heavy Chains/immunology ; Immunoglobulin Heavy Chains/metabolism ; Protein Structural Elements ; Single-Domain Antibodies/immunology ; Single-Domain Antibodies/metabolism ; beta 2-Microglobulin/immunology
Czasopismo naukowe
Tytuł:
Immunoglobulin gene rearrangement in Koreans with multiple myeloma: Clonality assessment and repertoire analysis using next-generation sequencing.
Autorzy:
Kim M; Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Jeon K; Department of Laboratory Medicine, Hangang Sacred Heart Hospital, Seoul, South Korea.
Hutt K; Invivoscribe, Inc., San Diego, California, United States of America.
Zlotnicki AM; Invivoscribe, Inc., San Diego, California, United States of America.
Kim HJ; Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, South Korea.
Lee J; Department of Laboratory Medicine, Green Cross Laboratories, Yongin, South Korea.
Kim HS; Department of Laboratory Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, South Korea.
Kang HJ; Department of Laboratory Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, South Korea.
Lee YK; Department of Laboratory Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, South Korea.
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Źródło:
PloS one [PLoS One] 2021 Jun 24; Vol. 16 (6), pp. e0253541. Date of Electronic Publication: 2021 Jun 24 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Rearrangement, B-Lymphocyte*
Immunoglobulin Heavy Chains*
Neoplasm Proteins*
Immunoglobulin kappa-Chains/*genetics
Adult ; Aged ; Aged, 80 and over ; Asian People ; Female ; High-Throughput Nucleotide Sequencing ; Humans ; Male ; Middle Aged ; Multiple Myeloma/ethnology ; Multiple Myeloma/genetics ; Republic of Korea/ethnology
Czasopismo naukowe
Tytuł:
Molecular characterization of a new IgZ3 subclass in common carp (Cyprinus carpio) and comparative expression analysis of IgH transcripts during larvae development.
Autorzy:
Zhang F; Key Laboratory of Animal Resistance Biology of Shandong Province, College of Life Sciences, Shandong Normal University, No. 88 East Wenhua Road, Shandong, 250014, Jinan, China. .
Li M; Key Laboratory of Animal Resistance Biology of Shandong Province, College of Life Sciences, Shandong Normal University, No. 88 East Wenhua Road, Shandong, 250014, Jinan, China.
Lv C; Laboratory of Immunology for Environment and Health, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), 250014, Jinan, China.
Wei G; Key Laboratory of Animal Resistance Biology of Shandong Province, College of Life Sciences, Shandong Normal University, No. 88 East Wenhua Road, Shandong, 250014, Jinan, China.
Wang C; Key Laboratory of Animal Resistance Biology of Shandong Province, College of Life Sciences, Shandong Normal University, No. 88 East Wenhua Road, Shandong, 250014, Jinan, China.
Wang Y; Key Laboratory of Animal Resistance Biology of Shandong Province, College of Life Sciences, Shandong Normal University, No. 88 East Wenhua Road, Shandong, 250014, Jinan, China.
An L; Key Laboratory of Animal Resistance Biology of Shandong Province, College of Life Sciences, Shandong Normal University, No. 88 East Wenhua Road, Shandong, 250014, Jinan, China. .
Yang G; Key Laboratory of Animal Resistance Biology of Shandong Province, College of Life Sciences, Shandong Normal University, No. 88 East Wenhua Road, Shandong, 250014, Jinan, China. .
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Źródło:
BMC veterinary research [BMC Vet Res] 2021 Apr 14; Vol. 17 (1), pp. 159. Date of Electronic Publication: 2021 Apr 14.
Typ publikacji:
Journal Article
MeSH Terms:
Carps/*immunology
Fish Diseases/*immunology
Immunoglobulin Heavy Chains/*genetics
Immunoglobulin Heavy Chains/*metabolism
Aeromonas hydrophila/immunology ; Animals ; Carps/growth & development ; Cloning, Molecular ; Fish Diseases/microbiology ; Fish Proteins/genetics ; Fish Proteins/metabolism ; Gene Expression Regulation, Developmental ; Immunoglobulin Heavy Chains/chemistry ; Larva/immunology ; Phylogeny ; Sequence Analysis, Protein
Czasopismo naukowe
Tytuł:
Sensitive immunoassay of Legionella using multivalent conjugates of engineered VHHs.
Autorzy:
Kiyose N; Graduate School of Science and Engineering, Kagoshima University, 1-21-35 Korimoto, Kagoshima 890-0065, Japan.; ARK Resource Co., Ltd., 383-2, Nakahara-machi, Nishi-ku, Kumamoto 861-5271, Japan.
Miyazaki N; ARK Resource Co., Ltd., 383-2, Nakahara-machi, Nishi-ku, Kumamoto 861-5271, Japan.
Furuhata K; School of Life and Environmental Science, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara-shi, Kanagawa 252-5201, Japan.
Ito Y; Graduate School of Science and Engineering, Kagoshima University, 1-21-35 Korimoto, Kagoshima 890-0065, Japan.
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Źródło:
Journal of biochemistry [J Biochem] 2023 Mar 07; Vol. 173 (3), pp. 185-195.
Typ publikacji:
Journal Article
MeSH Terms:
Legionella*
Legionnaires' Disease*
Single-Domain Antibodies*
Humans ; Antigens ; Immunoassay ; Immunoglobulin Heavy Chains
Czasopismo naukowe

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