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Wyszukujesz frazę ""Immunoglobulin Heavy Chains"" wg kryterium: Temat


Tytuł:
Antibody production relies on the tRNA inosine wobble modification to meet biased codon demand.
Autorzy:
Giguère S; The Ragon Institute of Mass General, Massachusetts Institute of Technology (MIT), and Harvard, Cambridge, MA 02139, USA.
Wang X; The Ragon Institute of Mass General, Massachusetts Institute of Technology (MIT), and Harvard, Cambridge, MA 02139, USA.
Huber S; Department of Biological Engineering, MIT, Cambridge, MA 02139, USA.
Xu L; The Ragon Institute of Mass General, Massachusetts Institute of Technology (MIT), and Harvard, Cambridge, MA 02139, USA.
Warner J; The Ragon Institute of Mass General, Massachusetts Institute of Technology (MIT), and Harvard, Cambridge, MA 02139, USA.
Weldon SR; The Ragon Institute of Mass General, Massachusetts Institute of Technology (MIT), and Harvard, Cambridge, MA 02139, USA.
Hu J; Department of Biological Engineering, MIT, Cambridge, MA 02139, USA.
Phan QA; The Ragon Institute of Mass General, Massachusetts Institute of Technology (MIT), and Harvard, Cambridge, MA 02139, USA.
Tumang K; The Ragon Institute of Mass General, Massachusetts Institute of Technology (MIT), and Harvard, Cambridge, MA 02139, USA.
Prum T; The Ragon Institute of Mass General, Massachusetts Institute of Technology (MIT), and Harvard, Cambridge, MA 02139, USA.
Ma D; BioMicro Center, MIT, Cambridge, MA 02139, USA.
Kirsch KH; The Ragon Institute of Mass General, Massachusetts Institute of Technology (MIT), and Harvard, Cambridge, MA 02139, USA.
Nair U; The Ragon Institute of Mass General, Massachusetts Institute of Technology (MIT), and Harvard, Cambridge, MA 02139, USA.
Dedon P; Department of Biological Engineering, MIT, Cambridge, MA 02139, USA.; Singapore-MIT Alliance for Research and Technology, Singapore 138602.
Batista FD; The Ragon Institute of Mass General, Massachusetts Institute of Technology (MIT), and Harvard, Cambridge, MA 02139, USA.; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA.; Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA.; Department of Biology, MIT, Cambridge, MA 02139, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2024 Jan 12; Vol. 383 (6679), pp. 205-211. Date of Electronic Publication: 2024 Jan 11.
Typ publikacji:
Journal Article
MeSH Terms:
Antibody Formation*/genetics
Codon Usage*
Inosine*/genetics
Inosine*/metabolism
RNA, Transfer*/genetics
Antibodies*/genetics
B-Lymphocytes*/immunology
Immunoglobulin Heavy Chains*/genetics
Codon/genetics ; Humans
Czasopismo naukowe
Tytuł:
Evaluation of the Potential Impact of In Silico Humanization on V H H Dynamics.
Autorzy:
Martins C; Université Paris Cité and Université de la Réunion and Université des Antilles, INSERM, BIGR, DSIMB, F-75014 Paris, France.; Université Paris Cité and Université de la Réunion and Université des Antilles, INSERM, BIGR, DSIMB, F-97715 Saint Denis Messag, France.
Diharce J; Université Paris Cité and Université de la Réunion and Université des Antilles, INSERM, BIGR, DSIMB, F-75014 Paris, France.
Nadaradjane AA; Université Paris Cité and Université de la Réunion and Université des Antilles, INSERM, BIGR, DSIMB, F-97715 Saint Denis Messag, France.
de Brevern AG; Université Paris Cité and Université de la Réunion and Université des Antilles, INSERM, BIGR, DSIMB, F-75014 Paris, France.; Université Paris Cité and Université de la Réunion and Université des Antilles, INSERM, BIGR, DSIMB, F-97715 Saint Denis Messag, France.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Sep 26; Vol. 24 (19). Date of Electronic Publication: 2023 Sep 26.
Typ publikacji:
Journal Article
MeSH Terms:
Immunoglobulin Heavy Chains*/chemistry
Camelids, New World*
Humans ; Animals ; Antibodies ; Biotechnology
Czasopismo naukowe
Tytuł:
Germline-encoded amino acid-binding motifs drive immunodominant public antibody responses.
Autorzy:
Shrock EL; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.; Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA.; Program in Biological and Biomedical Sciences, Harvard University, Boston, MA 02115, USA.
Timms RT; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK.
Kula T; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.; Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA.; Program in Biological and Biomedical Sciences, Harvard University, Boston, MA 02115, USA.
Mena EL; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.; Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA.
West AP Jr; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Guo R; Division of Infectious Disease, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA.
Lee IH; Center for Systems Biology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Cohen AA; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
McKay LGA; National Emerging Infectious Diseases Laboratories, Boston University School of Medicine, Boston University, Boston, MA 02118, USA.
Bi C; Division of Allergy and Immunology, Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Massachusetts Consortium on Pathogen Readiness, Boston, MA 02115, USA.
Leng Y; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.; Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA.
Fujimura E; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.; Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA.
Horns F; Department of Bioengineering, Department of Applied Physics, Chan Zuckerberg Biohub and Stanford University, Stanford, CA 94305, USA.
Li M; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.; Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA.
Wesemann DR; Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA.; Division of Allergy and Immunology, Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Massachusetts Consortium on Pathogen Readiness, Boston, MA 02115, USA.; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, 02139 USA.
Griffiths A; National Emerging Infectious Diseases Laboratories, Boston University School of Medicine, Boston University, Boston, MA 02118, USA.
Gewurz BE; Division of Infectious Disease, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA.; Graduate Program in Virology, Division of Medical Sciences, Harvard Medical School, Boston, MA 02115, USA.
Bjorkman PJ; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Elledge SJ; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.; Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2023 Apr 07; Vol. 380 (6640), pp. eadc9498. Date of Electronic Publication: 2023 Apr 07.
Typ publikacji:
Journal Article
MeSH Terms:
Antibody Formation*
Immunodominant Epitopes*/chemistry
Immunodominant Epitopes*/genetics
Immunoglobulin Heavy Chains*/genetics
Immunoglobulin Heavy Chains*/immunology
Amino Acid Motifs*
Immunoglobulin Light Chains*/genetics
Immunoglobulin Light Chains*/immunology
Host-Pathogen Interactions*/genetics
Host-Pathogen Interactions*/immunology
Animals ; Humans ; Mice ; Germ Cells ; Epitope Mapping
Czasopismo naukowe
Tytuł:
A Novel Strategy for Screening Tumor-Specific Variable Domain of Heavy-Chain Antibodies.
Autorzy:
Rafique A; Graduate School of Science and Engineering, University of Kagoshima, Kagoshima 890-0065, Japan.
Hichiwa G; Graduate School of Medical Sciences, Tottori University, Tottori 680-8550, Japan.
Jatnika MF; Graduate School of Science and Engineering, University of Kagoshima, Kagoshima 890-0065, Japan.
Ito Y; Graduate School of Science and Engineering, University of Kagoshima, Kagoshima 890-0065, Japan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jun 28; Vol. 24 (13). Date of Electronic Publication: 2023 Jun 28.
Typ publikacji:
Journal Article
MeSH Terms:
Immunoglobulin Heavy Chains*/genetics
Antibodies, Monoclonal*
Phylogeny ; Cell Line, Tumor ; Gene Library ; Peptide Library
Czasopismo naukowe
Tytuł:
Vaccination induces HIV broadly neutralizing antibody precursors in humans.
Autorzy:
Leggat DJ; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Cohen KW; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Willis JR; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Fulp WJ; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
deCamp AC; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Kalyuzhniy O; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Cottrell CA; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Menis S; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Finak G; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Ballweber-Fleming L; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Srikanth A; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Plyler JR; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Schiffner T; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Liguori A; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Rahaman F; IAVI, New York, NY 10004, USA.
Lombardo A; IAVI, New York, NY 10004, USA.
Philiponis V; IAVI, New York, NY 10004, USA.
Whaley RE; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Seese A; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Brand J; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Ruppel AM; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Hoyland W; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Yates NL; Center for Human Systems Immunology, Departments of Surgery, Immunology, Molecular Genetics and Microbiology, Duke University, Durham, NC 27701, USA.
Williams LD; Center for Human Systems Immunology, Departments of Surgery, Immunology, Molecular Genetics and Microbiology, Duke University, Durham, NC 27701, USA.
Greene K; Duke University Medical Center, Durham, NC 27701, USA.
Gao H; Duke University Medical Center, Durham, NC 27701, USA.
Mahoney CR; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Corcoran MM; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
Cagigi A; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Taylor A; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Brown DM; The Foundation for the National Institutes of Health, North Bethesda, MD 20852, USA.
Ambrozak DR; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Sincomb T; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Hu X; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Tingle R; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Georgeson E; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Eskandarzadeh S; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Alavi N; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Lu D; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Mullen TM; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Kubitz M; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Groschel B; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Maenza J; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.; Department of Medicine, University of Washington, Seattle, WA 98195, USA.
Kolokythas O; Department of Radiology, University of Washington, Seattle, WA 98195, USA.
Khati N; Department of Radiology, School of Medicine and Health Sciences, The George Washington University, Washington, DC 20037, USA.
Bethony J; Department of Microbiology, Immunology and Tropical Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, DC 20037, USA.
Crotty S; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego, La Jolla, CA 92037, USA.
Roederer M; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Karlsson Hedestam GB; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, SE-171 77 Stockholm, Sweden.; Department of Medicine, University of Washington, Seattle, WA 98195, USA.
Tomaras GD; Center for Human Systems Immunology, Departments of Surgery, Immunology, Molecular Genetics and Microbiology, Duke University, Durham, NC 27701, USA.
Montefiori D; Duke University Medical Center, Durham, NC 27701, USA.
Diemert D; Department of Microbiology, Immunology and Tropical Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, DC 20037, USA.; Department of Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, DC 20052, USA.
Koup RA; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Laufer DS; IAVI, New York, NY 10004, USA.
McElrath MJ; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.; Department of Medicine, University of Washington, Seattle, WA 98195, USA.
McDermott AB; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Schief WR; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.; The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2022 Dec 02; Vol. 378 (6623), pp. eadd6502. Date of Electronic Publication: 2022 Dec 02.
Typ publikacji:
Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
AIDS Vaccines*/immunology
Broadly Neutralizing Antibodies*/genetics
Broadly Neutralizing Antibodies*/immunology
HIV Infections*/prevention & control
HIV Antibodies*/genetics
HIV Antibodies*/immunology
Germ Cells*/immunology
Immunoglobulin Light Chains*/genetics
Immunoglobulin Light Chains*/immunology
Immunoglobulin Heavy Chains*/genetics
Immunoglobulin Heavy Chains*/immunology
Humans ; Adjuvants, Immunologic ; Vaccination ; B-Lymphocytes/immunology ; Mutation ; Male ; Female ; Adult
Czasopismo naukowe
Tytuł:
Enteric pharmacokinetics of monomeric and multimeric camelid nanobody single-domain antibodies.
Autorzy:
Debatis M; Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, United States of America.
Danz H; Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, United States of America.
Tremblay JM; Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, United States of America.
Gaspie K; Division of Animal Resources, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, United States of America.
Kudej RK; Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, United States of America.
Vigdorovich V; Center for Global Infectious Disease Research, Seattle Children's Hospital, Seattle, WA, United States of America.
Sather N; Center for Global Infectious Disease Research, Seattle Children's Hospital, Seattle, WA, United States of America.
Jaskiewicz JJ; Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, United States of America.
Tzipori S; Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, United States of America.
Shoemaker CB; Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, United States of America.
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Źródło:
PloS one [PLoS One] 2023 Nov 27; Vol. 18 (11), pp. e0291937. Date of Electronic Publication: 2023 Nov 27 (Print Publication: 2023).
Typ publikacji:
Journal Article
MeSH Terms:
Single-Domain Antibodies*
Camelids, New World*
Animals ; Humans ; Rabbits ; Swine ; Immunoglobulin Heavy Chains ; Antibodies, Monoclonal ; Amino Acid Sequence ; Peptide Hydrolases
Czasopismo naukowe
Tytuł:
Replication timing and genetic instability.
Autorzy:
Méchali M; Institute of Human Genetics, CNRS-University of Montpellier, Montpellier, France.
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Źródło:
Science (New York, N.Y.) [Science] 2022 Sep 16; Vol. 377 (6612), pp. 1259-1260. Date of Electronic Publication: 2022 Sep 15.
Typ publikacji:
Journal Article; Comment
MeSH Terms:
DNA Replication Timing*
Genomic Instability*
Immunoglobulin Heavy Chains*/genetics
Lymphoma, B-Cell*/genetics
Proto-Oncogene Proteins c-myc*/genetics
Replication Origin*
Translocation, Genetic*
Humans
Czasopismo naukowe
Tytuł:
Homozygous iMycCα transgenic mice as a model of plasma B-cell lymphomas.
Autorzy:
Ferrad M; UMR CNRS 7276, INSERM U1262, Equipe Labellisée LIGUE 2018, Université de Limoges, Limoges, France.
Ghazzaui N; UMR CNRS 7276, INSERM U1262, Equipe Labellisée LIGUE 2018, Université de Limoges, Limoges, France.
Issaoui H; UMR CNRS 7276, INSERM U1262, Equipe Labellisée LIGUE 2018, Université de Limoges, Limoges, France.
Drouineau E; I2BC, IBITEC-S, CEA, CNRS, Université Paris-Sud, Université Paris-Saclay, Gif-sur-Yvette, France.
Oblet C; UMR CNRS 7276, INSERM U1262, Equipe Labellisée LIGUE 2018, Université de Limoges, Limoges, France.
Marchiol T; UMR CNRS 7276, INSERM U1262, Equipe Labellisée LIGUE 2018, Université de Limoges, Limoges, France.
Cook-Moreau J; UMR CNRS 7276, INSERM U1262, Equipe Labellisée LIGUE 2018, Université de Limoges, Limoges, France.
Denizot Y; UMR CNRS 7276, INSERM U1262, Equipe Labellisée LIGUE 2018, Université de Limoges, Limoges, France.
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Źródło:
Leukemia & lymphoma [Leuk Lymphoma] 2022 Sep; Vol. 63 (9), pp. 2114-2125. Date of Electronic Publication: 2022 Apr 28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Immunoglobulin Heavy Chains*/genetics
Lymphoma, B-Cell*/genetics
Lymphoma, B-Cell*/pathology
Animals ; B-Lymphocytes/pathology ; Disease Models, Animal ; Humans ; Mice ; Mice, Transgenic ; Regulatory Sequences, Nucleic Acid
Czasopismo naukowe
Tytuł:
CD34+ cell of origin for immunoglobulin heavy chain variable region unmutated, but not mutated, chronic lymphocytic leukemia.
Autorzy:
Perkins B; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, John Hopkins University, Baltimore, MD, USA.
Showel M; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, John Hopkins University, Baltimore, MD, USA.
Schoch L; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, John Hopkins University, Baltimore, MD, USA.
Imus PH; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, John Hopkins University, Baltimore, MD, USA.
Karantanos T; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, John Hopkins University, Baltimore, MD, USA.
Yonescu R; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, John Hopkins University, Baltimore, MD, USA.
Morsberger L; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, John Hopkins University, Baltimore, MD, USA.
Ghiaur G; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, John Hopkins University, Baltimore, MD, USA.
Gladstone DE; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, John Hopkins University, Baltimore, MD, USA.
Jones RJ; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, John Hopkins University, Baltimore, MD, USA.
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Źródło:
Leukemia & lymphoma [Leuk Lymphoma] 2022 Jul; Vol. 63 (7), pp. 1617-1623. Date of Electronic Publication: 2022 Mar 27.
Typ publikacji:
Journal Article
MeSH Terms:
Immunoglobulin Heavy Chains*/genetics
Leukemia, Lymphocytic, Chronic, B-Cell*/genetics
Mutation*
Precursor Cells, B-Lymphoid*/immunology
Animals ; Antigens, CD19 ; Antigens, CD34 ; Chromosome Aberrations ; Flow Cytometry ; Heterografts ; Humans ; Mice ; Prognosis
Czasopismo naukowe
Tytuł:
Learning the statistics and landscape of somatic mutation-induced insertions and deletions in antibodies.
Autorzy:
Lupo C; Laboratoire de physique de l'École normale supérieure, CNRS, PSL University, Sorbonne Université, and Université de Paris, Paris, France.
Spisak N; Laboratoire de physique de l'École normale supérieure, CNRS, PSL University, Sorbonne Université, and Université de Paris, Paris, France.
Walczak AM; Laboratoire de physique de l'École normale supérieure, CNRS, PSL University, Sorbonne Université, and Université de Paris, Paris, France.
Mora T; Laboratoire de physique de l'École normale supérieure, CNRS, PSL University, Sorbonne Université, and Université de Paris, Paris, France.
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Źródło:
PLoS computational biology [PLoS Comput Biol] 2022 Jun 02; Vol. 18 (6), pp. e1010167. Date of Electronic Publication: 2022 Jun 02 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Genes, Immunoglobulin*
Immunoglobulin Heavy Chains*/genetics
Antibodies/genetics ; Humans ; INDEL Mutation/genetics ; Mutation
Czasopismo naukowe

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