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Tytuł:
Analysis of Mutational Status of IGHV , and Cytokine Polymorphisms as Prognostic Factors in Chronic Lymphocytic Leukemia: The Romanian Experience.
Autorzy:
Balla B; Department of Medical Genetics, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540139 Targu Mures, Romania.; Center for Advanced Medical and Pharmaceutical Research, Genetics Laboratory, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540139 Targu Mures, Romania.; Medical Genetics Laboratory, Emergency County Hospital of Targu Mures, 540136 Targu Mures, Romania.
Tripon F; Department of Medical Genetics, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540139 Targu Mures, Romania.; Center for Advanced Medical and Pharmaceutical Research, Genetics Laboratory, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540139 Targu Mures, Romania.; Medical Genetics Laboratory, Emergency County Hospital of Targu Mures, 540136 Targu Mures, Romania.
Lazar E; Department of Internal Medicine, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540139 Targu Mures, Romania.
Bănescu C; Department of Medical Genetics, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540139 Targu Mures, Romania.; Center for Advanced Medical and Pharmaceutical Research, Genetics Laboratory, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540139 Targu Mures, Romania.; Medical Genetics Laboratory, Emergency County Hospital of Targu Mures, 540136 Targu Mures, Romania.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 01; Vol. 25 (3). Date of Electronic Publication: 2024 Feb 01.
Typ publikacji:
Journal Article
MeSH Terms:
Leukemia, Lymphocytic, Chronic, B-Cell*/genetics
Leukemia, Lymphocytic, Chronic, B-Cell*/diagnosis
Humans ; Aged ; Immunoglobulin Variable Region/genetics ; Interleukin-10/genetics ; Cytokines/genetics ; Tumor Necrosis Factor-alpha/genetics ; Prognosis ; Romania ; Mutation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
General Trends of the Camelidae Antibody V H Hs Domain Dynamics.
Autorzy:
Vattekatte AM; Université de Paris, INSERM, BIGR, F-75014 Paris, France.; Université de la Réunion, INSERM, BIGR, F-97715 Saint-Denis, France.
Diharce J; Université de Paris, INSERM, BIGR, F-75014 Paris, France.
Rebehmed J; Department of Computer Science and Mathematics, Lebanese American University, Beirut 1102 2801, Lebanon.
Cadet F; Université de la Réunion, INSERM, BIGR, F-97715 Saint-Denis, France.; Artificial Intelligence Department, PEACCEL, Square Albin Cachot, F-75013 Paris, France.
Gardebien F; Université de la Réunion, INSERM, BIGR, F-97715 Saint-Denis, France.
Etchebest C; Université de Paris, INSERM, BIGR, F-75014 Paris, France.
de Brevern AG; Université de Paris, INSERM, BIGR, F-75014 Paris, France.; Université de la Réunion, INSERM, BIGR, F-97715 Saint-Denis, France.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Feb 24; Vol. 24 (5). Date of Electronic Publication: 2023 Feb 24.
Typ publikacji:
Journal Article
MeSH Terms:
Camelidae*
Immunoglobulin Variable Region*/chemistry
Animals ; Complementarity Determining Regions/chemistry ; Immunoglobulin Heavy Chains/chemistry ; Molecular Dynamics Simulation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Effect of non-repetitive linker on in vitro and in vivo properties of an anti-VEGF scFv.
Autorzy:
Arslan M; Izmir Biomedicine and Genome Center, Izmir, Turkey.; Izmir International Biomedicine and Genome Institute, Dokuz Eylul University, Izmir, Turkey.
Karadag M; Izmir Biomedicine and Genome Center, Izmir, Turkey.; Izmir International Biomedicine and Genome Institute, Dokuz Eylul University, Izmir, Turkey.
Onal E; Izmir Biomedicine and Genome Center, Izmir, Turkey.; Institute of Health Sciences, Dokuz Eylul University, Izmir, Turkey.
Gelinci E; Izmir Biomedicine and Genome Center, Izmir, Turkey.
Cakan-Akdogan G; Izmir Biomedicine and Genome Center, Izmir, Turkey.; Department of Medical Biology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.
Kalyoncu S; Izmir Biomedicine and Genome Center, Izmir, Turkey. .
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Źródło:
Scientific reports [Sci Rep] 2022 Mar 31; Vol. 12 (1), pp. 5449. Date of Electronic Publication: 2022 Mar 31.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Immunoglobulin Variable Region*/chemistry
Zebrafish*
Animals ; Antibodies, Monoclonal ; Immunoglobulin Fragments/chemistry ; Vascular Endothelial Growth Factors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Dramatic activation of an antibody by a single amino acid change in framework.
Autorzy:
Liang WC; Department of Antibody Engineering, Genentech Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
Yin J; Department of Structural Biology, Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
Lupardus P; Department of Structural Biology, Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
Zhang J; Department of Biochemical and Cellular Pharmacology, Genentech, 1 DNA Way, South San Francisco, CA, 94080, USA.
Loyet KM; Department of Biochemical and Cellular Pharmacology, Genentech, 1 DNA Way, South San Francisco, CA, 94080, USA.
Sudhamsu J; Department of Structural Biology, Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA. .; Department of Discovery Oncology, Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA. .
Wu Y; Department of Antibody Engineering, Genentech Inc., 1 DNA Way, South San Francisco, CA, 94080, USA. .
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Źródło:
Scientific reports [Sci Rep] 2021 Nov 16; Vol. 11 (1), pp. 22365. Date of Electronic Publication: 2021 Nov 16.
Typ publikacji:
Journal Article
MeSH Terms:
Amino Acid Substitution*
Antibodies, Monoclonal, Humanized/*chemistry
Immunoglobulin Fab Fragments/*chemistry
Immunoglobulin Variable Region/*chemistry
Transforming Growth Factor beta2/*chemistry
Transforming Growth Factor beta3/*chemistry
Animals ; Antibodies, Monoclonal, Humanized/genetics ; Crystallography, X-Ray ; Humans ; Immunoglobulin Fab Fragments/genetics ; Immunoglobulin Variable Region/genetics ; Protein Structure, Quaternary ; Rabbits ; Transforming Growth Factor beta2/genetics ; Transforming Growth Factor beta3/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Determination of variable region sequences from hybridoma immunoglobulins that target Mycobacterium tuberculosis virulence factors.
Autorzy:
Foreman HC; BEI Resources, ATCC., Manassas, Virginia, United States of America.
Frank A; BEI Resources, ATCC., Manassas, Virginia, United States of America.
Stedman TT; BEI Resources, ATCC., Manassas, Virginia, United States of America.
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Źródło:
PloS one [PLoS One] 2021 Aug 20; Vol. 16 (8), pp. e0256079. Date of Electronic Publication: 2021 Aug 20 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Immunoglobulin Variable Region/*genetics
Mycobacterium tuberculosis/*genetics
Mycobacterium tuberculosis/*immunology
Animals ; Antibodies, Monoclonal/immunology ; Antibody Specificity ; Antigens, Bacterial/immunology ; Enzyme-Linked Immunosorbent Assay/methods ; Humans ; Hybridomas/immunology ; Immunoglobulin G ; Immunoglobulin Variable Region/immunology ; Immunoglobulins/immunology ; Immunologic Factors ; Immunologic Tests/methods ; Mice ; Mycobacterium tuberculosis/pathogenicity ; Tuberculosis/microbiology ; Virulence Factors/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A Germline-Encoded Structural Arginine Trap Underlies the Anti-DNA Reactivity of a Murine V Gene Segment.
Autorzy:
Dos Santos Araújo RP; Department of Cellular Biology, Institute of Biology, University of Brasilia, Brasilia 70910-900, Brazil.
França RKA; Department of Cellular Biology, Institute of Biology, University of Brasilia, Brasilia 70910-900, Brazil.
Valadares NF; Department of Cellular Biology, Institute of Biology, University of Brasilia, Brasilia 70910-900, Brazil.
Maranhão AQ; Department of Cellular Biology, Institute of Biology, University of Brasilia, Brasilia 70910-900, Brazil.; Instituto Nacional de Ciência e Tecnologia (iii-INCT), São Paulo 05403-000, Brazil.
Brigido MM; Department of Cellular Biology, Institute of Biology, University of Brasilia, Brasilia 70910-900, Brazil.; Instituto Nacional de Ciência e Tecnologia (iii-INCT), São Paulo 05403-000, Brazil.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Apr 26; Vol. 22 (9). Date of Electronic Publication: 2021 Apr 26.
Typ publikacji:
Journal Article
MeSH Terms:
Immunoglobulin Variable Region/*genetics
Single-Domain Antibodies/*genetics
Single-Domain Antibodies/*immunology
Amino Acid Sequence/genetics ; Animals ; Antibodies, Antinuclear/genetics ; Arginine/genetics ; Arginine/metabolism ; Autoantigens/genetics ; Autoimmunity/immunology ; Base Sequence/genetics ; DNA/immunology ; Germ Cells/immunology ; Humans ; Immunoglobulin Heavy Chains/genetics ; Immunoglobulin Heavy Chains/metabolism ; Immunoglobulin Variable Region/metabolism ; Immunoglobulin Variable Region/ultrastructure ; Mice ; Single-Domain Antibodies/ultrastructure ; Structure-Activity Relationship
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
A single-chain antibody generation system yielding CAR-T cells with superior antitumor function.
Autorzy:
Ochi T; Department of Hematology, Clinical Immunology, and Infectious Diseases, Ehime University Graduate School of Medicine, Toon, Ehime, Japan. .; Division of Immune Regulation, Proteo-Science Center, Ehime University, Toon, Ehime, Japan. .
Maruta M; Department of Hematology, Clinical Immunology, and Infectious Diseases, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.
Tanimoto K; Department of Hematology, Clinical Immunology, and Infectious Diseases, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.
Kondo F; Department of Hematology, Clinical Immunology, and Infectious Diseases, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.
Yamamoto T; Department of Analytical Pathology, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.
Kurata M; Department of Analytical Pathology, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.; Division of Pathology, Proteo-Science Center, Ehime University, Toon, Ehime, Japan.
Fujiwara H; Department of Hematology, Clinical Immunology, and Infectious Diseases, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.; Department of Personalized Cancer Immunotherapy, Mie University Graduate School of Medicine, Tsu, Mie, Japan.
Masumoto J; Department of Analytical Pathology, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.; Division of Pathology, Proteo-Science Center, Ehime University, Toon, Ehime, Japan.
Takenaka K; Department of Hematology, Clinical Immunology, and Infectious Diseases, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.
Yasukawa M; Division of Immune Regulation, Proteo-Science Center, Ehime University, Toon, Ehime, Japan.; Ehime Prefectural University of Health Sciences, Tobe, Ehime, Japan.
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Źródło:
Communications biology [Commun Biol] 2021 Mar 02; Vol. 4 (1), pp. 273. Date of Electronic Publication: 2021 Mar 02.
Typ publikacji:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Immunotherapy, Adoptive*
Immunoglobulin Heavy Chains/*metabolism
Immunoglobulin Light Chains/*metabolism
Immunoglobulin Variable Region/*metabolism
Lymphoma/*therapy
Receptors, Chimeric Antigen/*metabolism
Single-Chain Antibodies/*metabolism
T-Lymphocytes/*transplantation
Animals ; Female ; Humans ; Immunoglobulin Heavy Chains/genetics ; Immunoglobulin Light Chains/genetics ; Immunoglobulin Variable Region/genetics ; Immunological Synapses ; Jurkat Cells ; K562 Cells ; Lymphoma/genetics ; Lymphoma/immunology ; Lymphoma/metabolism ; Mice, Inbred NOD ; Mice, SCID ; Receptors, Chimeric Antigen/genetics ; Single-Chain Antibodies/genetics ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; Tumor Burden ; Xenograft Model Antitumor Assays ; Mice
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Genetics and epigenetics of CLL.
Autorzy:
Paul P; Department of Hematology, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.
Stüssi G; Department of Hematology, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.
Bruscaggin A; Laboratory of Experimental Hematology, Institute of Oncology of Southern Switzerland, Institute of Oncology Research, Bellinzona, Switzerland.
Rossi D; Department of Hematology, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.; Laboratory of Experimental Hematology, Institute of Oncology of Southern Switzerland, Institute of Oncology Research, Bellinzona, Switzerland.
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Źródło:
Leukemia & lymphoma [Leuk Lymphoma] 2023 Mar; Vol. 64 (3), pp. 551-563. Date of Electronic Publication: 2022 Dec 12.
Typ publikacji:
Review; Journal Article
MeSH Terms:
Leukemia, Lymphocytic, Chronic, B-Cell*/diagnosis
Leukemia, Lymphocytic, Chronic, B-Cell*/genetics
Humans ; Immunoglobulin Heavy Chains/genetics ; Immunoglobulin Variable Region/genetics ; Epigenomics ; Epigenesis, Genetic ; Mutation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Low-data interpretable deep learning prediction of antibody viscosity using a biophysically meaningful representation.
Autorzy:
Rai BK; Pfizer Worldwide Research Development and Medical, Machine Learning and Computational Sciences, 610 Main Street, Cambridge, MA, 02139, USA. .
Apgar JR; Pfizer Worldwide Research Development and Medical, Biomedicine Design, 610 Main Street, Cambridge, MA, 02139, USA.
Bennett EM; Pfizer Worldwide Research Development and Medical, Biomedicine Design, 610 Main Street, Cambridge, MA, 02139, USA.
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Źródło:
Scientific reports [Sci Rep] 2023 Feb 20; Vol. 13 (1), pp. 2917. Date of Electronic Publication: 2023 Feb 20.
Typ publikacji:
Journal Article
MeSH Terms:
Deep Learning*
Viscosity ; Antibodies ; Immunoglobulin Variable Region ; Big Data
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Antibodies exhibit multiple paratope states influencing V H -V L domain orientations.
Autorzy:
Fernández-Quintero ML; Institute of General, Inorganic and Theoretical Chemistry, and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, A-6020, Innsbruck, Austria.
Pomarici ND; Institute of General, Inorganic and Theoretical Chemistry, and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, A-6020, Innsbruck, Austria.
Math BA; Institute of General, Inorganic and Theoretical Chemistry, and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, A-6020, Innsbruck, Austria.
Kroell KB; Institute of General, Inorganic and Theoretical Chemistry, and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, A-6020, Innsbruck, Austria.
Waibl F; Institute of General, Inorganic and Theoretical Chemistry, and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, A-6020, Innsbruck, Austria.
Bujotzek A; Roche Pharma Research and Early Development, Large Molecule Research, Roche Innovation Center Munich, Penzberg, Germany.
Georges G; Roche Pharma Research and Early Development, Large Molecule Research, Roche Innovation Center Munich, Penzberg, Germany.
Liedl KR; Institute of General, Inorganic and Theoretical Chemistry, and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, A-6020, Innsbruck, Austria. .
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Źródło:
Communications biology [Commun Biol] 2020 Oct 20; Vol. 3 (1), pp. 589. Date of Electronic Publication: 2020 Oct 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Binding Sites, Antibody*
Protein Interaction Domains and Motifs*
Antibodies/*chemistry
Immunoglobulin Heavy Chains/*chemistry
Immunoglobulin Light Chains/*chemistry
Immunoglobulin Variable Region/*chemistry
Antibodies/immunology ; Immunoglobulin Fab Fragments/chemistry ; Immunoglobulin Fab Fragments/immunology ; Immunoglobulin Heavy Chains/immunology ; Immunoglobulin Light Chains/immunology ; Immunoglobulin Variable Region/immunology ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Protein Binding ; Protein Conformation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Characterization of Variable Region Genes and Discovery of Key Recognition Sites in the Complementarity Determining Regions of the Anti-Thiacloprid Monoclonal Antibody.
Autorzy:
Liu P; Institute of Pesticide and Environmental Toxicology, Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Zhejiang University, Hangzhou 310058, China.
Guo Y; Institute of Pesticide and Environmental Toxicology, Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Zhejiang University, Hangzhou 310058, China.
Jiao S; Institute of Pesticide and Environmental Toxicology, Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Zhejiang University, Hangzhou 310058, China.
Chang Y; Institute of Pesticide and Environmental Toxicology, Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Zhejiang University, Hangzhou 310058, China.
Liu Y; Institute of Pesticide and Environmental Toxicology, Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Zhejiang University, Hangzhou 310058, China.; Department of Food Science and Nutrition, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University, Hangzhou 310058, China.
Zou R; Institute of Pesticide and Environmental Toxicology, Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Zhejiang University, Hangzhou 310058, China.
Liu Y; Institute of Pesticide and Environmental Toxicology, Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Zhejiang University, Hangzhou 310058, China.; Research Institute of Subtropical Forestry, Chinese Academy of Forestry, Hangzhou 311400, China.
Chen M; Institute of Pesticide and Environmental Toxicology, Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Zhejiang University, Hangzhou 310058, China.; Zhejiang Provincial Key Laboratory of Biometrology and Inspection & Quarantine, College of life sciences, China Jiliang University, Hangzhou 310018, China.
Guo Y; Institute of Pesticide and Environmental Toxicology, Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Zhejiang University, Hangzhou 310058, China.
Zhu G; Institute of Pesticide and Environmental Toxicology, Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Zhejiang University, Hangzhou 310058, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Sep 18; Vol. 21 (18). Date of Electronic Publication: 2020 Sep 18.
Typ publikacji:
Journal Article
MeSH Terms:
Antibodies, Monoclonal/*genetics
Antibodies, Monoclonal/*immunology
Complementarity Determining Regions/*chemistry
Immunoglobulin Variable Region/*genetics
Insecticides/*immunology
Neonicotinoids/*immunology
Thiazines/*immunology
Amino Acid Sequence ; Animals ; Antibodies, Monoclonal/chemistry ; Chromatography, Liquid ; Female ; HEK293 Cells ; High-Throughput Nucleotide Sequencing ; Humans ; Hybridomas/metabolism ; Hydrogen Bonding ; Immunoglobulin Heavy Chains/genetics ; Immunoglobulin Variable Region/chemistry ; Inhibitory Concentration 50 ; Kinetics ; Mice ; Mice, Inbred BALB C ; Molecular Docking Simulation ; Mutagenesis, Site-Directed ; Tandem Mass Spectrometry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Site-Specific Antibody-Drug Conjugates in Triple Variable Domain Fab Format.
Autorzy:
Hwang D; Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL 33458, USA.
Rader C; Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL 33458, USA.
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Źródło:
Biomolecules [Biomolecules] 2020 May 14; Vol. 10 (5). Date of Electronic Publication: 2020 May 14.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Immunoconjugates/*immunology
Immunoglobulin Variable Region/*immunology
Protein Engineering/*methods
Receptor, ErbB-2/*immunology
Animals ; Antibodies, Catalytic/chemistry ; Antibodies, Catalytic/immunology ; Antineoplastic Agents/chemistry ; Catalytic Domain ; Cell Line, Tumor ; Female ; Humans ; Immunoconjugates/pharmacokinetics ; Immunoglobulin Variable Region/chemistry ; Mice ; Mice, Inbred NOD ; Oligopeptides/chemistry ; Tissue Distribution ; Tubulin Modulators/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Murine gammaherpesvirus infection is skewed toward Igλ+ B cells expressing a specific heavy chain V-segment.
Autorzy:
Collins CM; Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America.
Scharer CD; Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America.
Murphy TJ; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia, United States of America.
Boss JM; Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America.
Speck SH; Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America.
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Źródło:
PLoS pathogens [PLoS Pathog] 2020 Apr 30; Vol. 16 (4), pp. e1008438. Date of Electronic Publication: 2020 Apr 30 (Print Publication: 2020).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
B-Lymphocytes/*immunology
Gammaherpesvirinae/*physiology
Herpesviridae Infections/*veterinary
Immunoglobulin Heavy Chains/*immunology
Immunoglobulin Variable Region/*immunology
Immunoglobulin lambda-Chains/*immunology
Rodent Diseases/*immunology
Animals ; B-Lymphocytes/virology ; Female ; Gammaherpesvirinae/genetics ; Germinal Center/immunology ; Germinal Center/virology ; Herpesviridae Infections/genetics ; Herpesviridae Infections/immunology ; Herpesviridae Infections/virology ; Immunoglobulin Heavy Chains/genetics ; Immunoglobulin Variable Region/genetics ; Immunoglobulin lambda-Chains/genetics ; Mice ; Mice, Inbred C57BL ; Plasma Cells/immunology ; Plasma Cells/virology ; Receptors, Antigen, B-Cell/genetics ; Receptors, Antigen, B-Cell/immunology ; Rodent Diseases/genetics ; Rodent Diseases/virology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Optimizing antibody affinity and stability by the automated design of the variable light-heavy chain interfaces.
Autorzy:
Warszawski S; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.
Borenstein Katz A; Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel.
Lipsh R; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.
Khmelnitsky L; Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel.
Ben Nissan G; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.
Javitt G; Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel.
Dym O; Israel Structural Proteomics Center, Weizmann Institute of Science, Rehovot, Israel.
Unger T; Israel Structural Proteomics Center, Weizmann Institute of Science, Rehovot, Israel.
Knop O; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.
Albeck S; Israel Structural Proteomics Center, Weizmann Institute of Science, Rehovot, Israel.
Diskin R; Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel.
Fass D; Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel.
Sharon M; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.
Fleishman SJ; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.
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Źródło:
PLoS computational biology [PLoS Comput Biol] 2019 Aug 23; Vol. 15 (8), pp. e1007207. Date of Electronic Publication: 2019 Aug 23 (Print Publication: 2019).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antibody Affinity*/genetics
Drug Design*
Immunoglobulin Variable Region/*genetics
Protein Engineering/*methods
Animals ; Computational Biology ; HEK293 Cells ; Humans ; Immunoglobulin Fragments/chemistry ; Immunoglobulin Fragments/genetics ; Immunoglobulin Heavy Chains/chemistry ; Immunoglobulin Heavy Chains/genetics ; Immunoglobulin Light Chains/chemistry ; Immunoglobulin Light Chains/genetics ; Immunoglobulin Variable Region/chemistry ; Models, Molecular ; Mutagenesis, Site-Directed ; Mutation ; Oxidoreductases Acting on Sulfur Group Donors/antagonists & inhibitors ; Oxidoreductases Acting on Sulfur Group Donors/immunology ; Peptide Library ; Protein Engineering/statistics & numerical data ; Protein Stability ; Software ; Vascular Endothelial Growth Factor A/antagonists & inhibitors ; Vascular Endothelial Growth Factor A/immunology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Cyclization of Single-Chain Fv Antibodies Markedly Suppressed Their Characteristic Aggregation Mediated by Inter-Chain VH-VL Interactions.
Autorzy:
Yamauchi S; Department of Analytical and Biophysical Chemistry, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan.
Kobashigawa Y; Department of Analytical and Biophysical Chemistry, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan.
Fukuda N; Department of Analytical and Biophysical Chemistry, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan.
Teramoto M; Department of Analytical and Biophysical Chemistry, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan.
Toyota Y; Department of Analytical and Biophysical Chemistry, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan.
Liu C; Department of Analytical and Biophysical Chemistry, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan.
Ikeguchi Y; Department of Analytical and Biophysical Chemistry, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan.
Sato T; Department of Analytical and Biophysical Chemistry, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan.
Sato Y; Cell Biology Center, Institute of Innovative Research, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku, Yokohama 226-8503, Japan.
Kimura H; Cell Biology Center, Institute of Innovative Research, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku, Yokohama 226-8503, Japan.
Masuda T; Department of Pharmaceutical Microbiology, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan.
Ohtsuki S; Department of Pharmaceutical Microbiology, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan.
Noi K; Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita 565-0871, Japan.; Institute for NanoScience Design, Osaka University, 1-3 Machikaneyama, Toyonaka 560-8531, Japan.
Ogura T; Department of Molecular Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto 860-0811, Japan.; CREST, JST, 4-1-8, Honcho, Kawaguchi, Saitama 332-0012, Japan.
Morioka H; Department of Analytical and Biophysical Chemistry, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan. .
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2019 Jul 18; Vol. 24 (14). Date of Electronic Publication: 2019 Jul 18.
Typ publikacji:
Journal Article
MeSH Terms:
Immunoglobulin Heavy Chains/*chemistry
Immunoglobulin Light Chains/*chemistry
Immunoglobulin Variable Region/*chemistry
Single-Chain Antibodies/*chemistry
Calorimetry, Differential Scanning ; Cyclization ; Dynamic Light Scattering ; Humans ; Immunoglobulin Heavy Chains/metabolism ; Immunoglobulin Light Chains/metabolism ; Immunoglobulin Variable Region/metabolism ; Microscopy, Atomic Force ; Protein Aggregates ; Protein Binding ; Single-Chain Antibodies/metabolism ; Surface Plasmon Resonance
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Isolation and purification of recombinant immunoglobulin light chain variable domains from the periplasmic space of Escherichia coli.
Autorzy:
Hand K; Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom.
Wilkinson MC; Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom.
Madine J; Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom.
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Źródło:
PloS one [PLoS One] 2018 Oct 22; Vol. 13 (10), pp. e0206167. Date of Electronic Publication: 2018 Oct 22 (Print Publication: 2018).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Escherichia coli/*growth & development
Immunoglobulin Light-chain Amyloidosis/*diagnosis
Immunoglobulin Variable Region/*isolation & purification
Periplasm/*immunology
Animals ; Cell Line ; Escherichia coli/genetics ; Humans ; Immunoglobulin Light Chains/chemistry ; Immunoglobulin Light Chains/genetics ; Immunoglobulin Light Chains/isolation & purification ; Immunoglobulin Light-chain Amyloidosis/immunology ; Immunoglobulin Variable Region/chemistry ; Immunoglobulin Variable Region/genetics ; Microscopy, Confocal ; Myocytes, Cardiac/immunology ; Myocytes, Cardiac/ultrastructure ; Protein Structure, Secondary ; Rats ; Recombinant Proteins/chemistry ; Recombinant Proteins/isolation & purification
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Precipitating anti-dsDNA peptide repertoires in lupus.
Autorzy:
Wang JJ; Department of Immunology, Flinders Medical Centre and Flinders University, SA Pathology, Bedford Park, SA, Australia.
Colella AD; Department of Immunology, Flinders Medical Centre and Flinders University, SA Pathology, Bedford Park, SA, Australia.
Beroukas D; Department of Immunology, Flinders Medical Centre and Flinders University, SA Pathology, Bedford Park, SA, Australia.
Chataway TK; Flinders Proteomics Facility, Flinders University, Bedford Park, SA, Australia.
Gordon TP; Department of Immunology, Flinders Medical Centre and Flinders University, SA Pathology, Bedford Park, SA, Australia.
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Źródło:
Clinical and experimental immunology [Clin Exp Immunol] 2018 Dec; Vol. 194 (3), pp. 273-282. Date of Electronic Publication: 2018 Oct 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antibodies, Antinuclear/*genetics
Complementarity Determining Regions/*genetics
Immunoglobulin Variable Region/*genetics
Immunoglobulin kappa-Chains/*genetics
Lupus Erythematosus, Systemic/*immunology
Adult ; Aged, 80 and over ; Amino Acid Sequence ; Amino Acid Substitution/genetics ; Antibodies, Antinuclear/blood ; Antibodies, Antinuclear/immunology ; DNA/immunology ; Female ; Humans ; Immunoglobulin G/genetics ; Immunoglobulin G/immunology ; Immunoglobulin Variable Region/immunology ; Immunoglobulin kappa-Chains/immunology ; Male ; Mass Spectrometry ; Middle Aged ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Variable-heavy (VH) families influencing IgA1&2 engagement to the antigen, FcαRI and superantigen proteins G, A, and L.
Autorzy:
Ling WL; Antibody & Product Development Lab, Experimental Drug Development Centre, Bioinformatics Institute, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Newcastle University Singapore, Singapore, Singapore.
Su CT; Antibody & Product Development Lab, Experimental Drug Development Centre, Bioinformatics Institute, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
Lua WH; Antibody & Product Development Lab, Experimental Drug Development Centre, Bioinformatics Institute, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
Yeo JY; Antibody & Product Development Lab, Experimental Drug Development Centre, Bioinformatics Institute, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
Poh JJ; Antibody & Product Development Lab, Experimental Drug Development Centre, Bioinformatics Institute, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
Ng YL; Newcastle University Singapore, Singapore, Singapore.
Wipat A; School of Computing, Newcastle University, Newcastle upon Tyne, UK.
Gan SK; Antibody & Product Development Lab, Experimental Drug Development Centre, Bioinformatics Institute, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore. .; James Cook University, Singapore, Singapore. .; Zhejiang Bioinformatics International Science and Technology Cooperation Center, Wenzhou-Kean University, Wenzhou, Zhejiang Province, China. .; Wenzhou Municipal Key Lab of Applied Biomedical and Biopharmaceutical Informatics, Wenzhou-Kean University, Wenzhou, Zhejiang Province, China. .
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Źródło:
Scientific reports [Sci Rep] 2022 Apr 20; Vol. 12 (1), pp. 6510. Date of Electronic Publication: 2022 Apr 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Immunoglobulin A*/metabolism
Superantigens*
Antigens ; Humans ; Immunoglobulin Heavy Chains/genetics ; Immunoglobulin Variable Region/genetics ; Oncogenes
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Application of camelid heavy-chain variable domains (VHHs) in prevention and treatment of bacterial and viral infections.
Autorzy:
Wilken L; a School of Pharmacy and Life Sciences , Robert Gordon University , Garthdee Road, Aberdeen , United Kingdom.; b Department of Natural Sciences , Hochschule Bonn-Rhein-Sieg , Rheinbach , Germany.
McPherson A; a School of Pharmacy and Life Sciences , Robert Gordon University , Garthdee Road, Aberdeen , United Kingdom.
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Źródło:
International reviews of immunology [Int Rev Immunol] 2018 Jan 02; Vol. 37 (1), pp. 69-76. Date of Electronic Publication: 2017 Nov 28.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Bacterial Infections/*prevention & control
Camelidae/*immunology
Immunoglobulin Heavy Chains/*therapeutic use
Immunoglobulin Variable Region/*therapeutic use
Virus Diseases/*prevention & control
Animals ; Bacterial Infections/immunology ; Bacterial Infections/therapy ; Camelidae/genetics ; Dental Caries/microbiology ; Dental Caries/therapy ; Diarrhea/microbiology ; Diarrhea/prevention & control ; Escherichia coli Infections/prevention & control ; Humans ; Immunization, Passive ; Immunoglobulin Heavy Chains/biosynthesis ; Immunoglobulin Heavy Chains/genetics ; Immunoglobulin Variable Region/biosynthesis ; Immunoglobulin Variable Region/genetics ; Lipopolysaccharides/antagonists & inhibitors ; Lipopolysaccharides/toxicity ; Poliomyelitis/prevention & control ; Recombinant Proteins/biosynthesis ; Recombinant Proteins/genetics ; Recombinant Proteins/therapeutic use ; Respiratory Syncytial Virus Infections/therapy ; Streptococcus mutans/immunology ; Virus Diseases/immunology ; Virus Diseases/therapy
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Epigenetic modifications of the V H region after DJ H recombination in Pro-B cells.
Autorzy:
Dong Y; Department of Pathogenic Biology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Centre, Xi'an, Shaanxi, China.; Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education of China, Xi'an, Shaanxi, China.
Wu C; Department of Pathogenic Biology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Centre, Xi'an, Shaanxi, China.; Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education of China, Xi'an, Shaanxi, China.
Zhao X; Department of Pathogenic Biology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Centre, Xi'an, Shaanxi, China.; Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education of China, Xi'an, Shaanxi, China.
Zhang P; Department of Pathogenic Biology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Centre, Xi'an, Shaanxi, China.; Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education of China, Xi'an, Shaanxi, China.
Zhang H; Department of Pathogenic Biology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Centre, Xi'an, Shaanxi, China.; Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education of China, Xi'an, Shaanxi, China.
Zheng M; Department of Pathogenic Biology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Centre, Xi'an, Shaanxi, China.; Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education of China, Xi'an, Shaanxi, China.
Li S; Department of Pathogenic Biology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Centre, Xi'an, Shaanxi, China.; Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education of China, Xi'an, Shaanxi, China.
Jiao J; Department of Pathogenic Biology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Centre, Xi'an, Shaanxi, China.; Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education of China, Xi'an, Shaanxi, China.
Yu X; Department of Pathogenic Biology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Centre, Xi'an, Shaanxi, China.; Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education of China, Xi'an, Shaanxi, China.
Lv Z; Department of Pathogenic Biology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Centre, Xi'an, Shaanxi, China.; Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education of China, Xi'an, Shaanxi, China.
Ji Y; Department of Pathogenic Biology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Centre, Xi'an, Shaanxi, China.; Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education of China, Xi'an, Shaanxi, China.
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Źródło:
Immunology [Immunology] 2017 Oct; Vol. 152 (2), pp. 218-231. Date of Electronic Publication: 2017 Jun 23.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Epigenesis, Genetic*
Gene Rearrangement, B-Lymphocyte*
Genes, Immunoglobulin Heavy Chain*
Immunoglobulin Variable Region/*genetics
Precursor Cells, B-Lymphoid/*immunology
Acetylation ; Animals ; Cell Line, Transformed ; Chromatin Immunoprecipitation ; DNA-Binding Proteins/immunology ; DNA-Binding Proteins/metabolism ; Genes, abl ; HEK293 Cells ; Histones/metabolism ; Homeodomain Proteins/immunology ; Homeodomain Proteins/metabolism ; Humans ; Immunoglobulin Joining Region/genetics ; Immunoglobulin Joining Region/immunology ; Immunoglobulin Variable Region/immunology ; Immunoglobulin Variable Region/metabolism ; Methylation ; Mice ; Mice, Inbred C57BL ; PAX5 Transcription Factor/genetics ; PAX5 Transcription Factor/metabolism ; Precursor Cells, B-Lymphoid/metabolism ; Protein Binding ; Protein Processing, Post-Translational ; Transcription, Genetic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
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