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Tytuł:
A cell-based phenotypic library selection and screening approach for the de novo discovery of novel functional chimeric antigen receptors.
Autorzy:
Fierle JK; LAbCore Immunoglobulin Discovery Platform, Department of Oncology, Ludwig Institute for Cancer Research Lausanne, University of Lausanne, 1066, Epalinges, Switzerland.
Abram-Saliba J; LAbCore Immunoglobulin Discovery Platform, Department of Oncology, Ludwig Institute for Cancer Research Lausanne, University of Lausanne, 1066, Epalinges, Switzerland.
Atsaves V; LAbCore Immunoglobulin Discovery Platform, Department of Oncology, Ludwig Institute for Cancer Research Lausanne, University of Lausanne, 1066, Epalinges, Switzerland.
Brioschi M; LAbCore Immunoglobulin Discovery Platform, Department of Oncology, Ludwig Institute for Cancer Research Lausanne, University of Lausanne, 1066, Epalinges, Switzerland.
de Tiani M; LAbCore Immunoglobulin Discovery Platform, Department of Oncology, Ludwig Institute for Cancer Research Lausanne, University of Lausanne, 1066, Epalinges, Switzerland.
Reichenbach P; Department of Oncology, Ludwig Institute for Cancer Research Lausanne, University of Lausanne, 1066, Epalinges, Switzerland.
Irving M; Department of Oncology, Ludwig Institute for Cancer Research Lausanne, University of Lausanne, 1066, Epalinges, Switzerland.
Coukos G; Department of Oncology, Ludwig Institute for Cancer Research Lausanne, Lausanne University Hospital and University of Lausanne, 1005, Lausanne, Switzerland.; Department of Oncology, Centre Hospitalier Universitaire Vaudois (CHUV), 1011, Lausanne, Switzerland.
Dunn SM; LAbCore Immunoglobulin Discovery Platform, Department of Oncology, Ludwig Institute for Cancer Research Lausanne, University of Lausanne, 1066, Epalinges, Switzerland. .; Department of Oncology, Ludwig Institute for Cancer Research Lausanne, Lausanne University Hospital and University of Lausanne, 1066, Epalinges, Switzerland. .
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Źródło:
Scientific reports [Sci Rep] 2022 Jan 21; Vol. 12 (1), pp. 1136. Date of Electronic Publication: 2022 Jan 21.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Neoplasms/*therapy
Receptors, Chimeric Antigen/*isolation & purification
T-Lymphocytes, Cytotoxic/*immunology
Cell Line, Tumor ; Gene Library ; HEK293 Cells ; Healthy Volunteers ; Humans ; Immunotherapy, Adoptive/methods ; Neoplasms/immunology ; Neoplasms/pathology ; Primary Cell Culture ; Receptors, Chimeric Antigen/genetics ; Receptors, Chimeric Antigen/immunology ; Single-Chain Antibodies/immunology ; Single-Chain Antibodies/metabolism ; T-Lymphocytes, Cytotoxic/metabolism ; T-Lymphocytes, Cytotoxic/transplantation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Optimized Dose of Dendritic Cell-based Vaccination in Experimental Model of Tumor Using Artificial Neural Network.
Autorzy:
Mirsanei Z; Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. sr_.
Habibi S; Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. .
Kheshtchin N; Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Kheshtchin_.
Mirzaei R; Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. .
Arab S; Nervous System Stem Cells Research Center, Semnan University of Medical Sciences, Semnan, Iran AND Department of Tissue Engineering and Applied Cell Sciences, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran. .
Zand B; Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. .
Jadidi-Niaragh F; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. .
Safvati A; Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. .
Sharif-Paghaleh E; Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran AND Division of Imaging Sciences and Biomedical Engineering, Faculty of Life Sciences and Medicine, St Thomas' Hospital, King's College London, London, England. Sharif_.
Arabameri A; Faculty of Electrical Engineering, K.N. Toosi University of Technology, Tehran, Iran. .
Asemani D; Faculty of Electrical Engineering, K.N. Toosi University of Technology, Tehran, Iran AND Division of Pediatrics, Liposomal Cancer Therapy, Medical University of South Carolina, Charleston, SC, USA. .
Hajati J; Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran AND Cancer Biology Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran. .
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Źródło:
Iranian journal of allergy, asthma, and immunology [Iran J Allergy Asthma Immunol] 2020 Apr 16; Vol. 19 (2), pp. 172-182. Date of Electronic Publication: 2020 Apr 16.
Typ publikacji:
Journal Article
MeSH Terms:
Immunotherapy, Adoptive*
Cancer Vaccines/*immunology
Dendritic Cells/*immunology
Fibrosarcoma/*therapy
T-Lymphocytes, Cytotoxic/*immunology
Animals ; Cell Line, Tumor ; Cell Proliferation ; Dendritic Cells/transplantation ; Fibrosarcoma/immunology ; Gene Expression Regulation, Neoplastic ; Humans ; Immunity/genetics ; Mice ; Mice, Inbred BALB C ; Models, Animal ; Models, Theoretical ; Neoplasm Transplantation ; Neural Networks, Computer ; Tumor Burden ; Vaccination
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Metabolic radiolabeling and in vivo PET imaging of cytotoxic T lymphocytes to guide combination adoptive cell transfer cancer therapy.
Autorzy:
Lu D; Medical Isotopes Research Center and Department of Radiation Medicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China.
Wang Y; Medical Isotopes Research Center and Department of Radiation Medicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China.
Zhang T; Medical Isotopes Research Center and Department of Radiation Medicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China.
Wang F; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing, 100142, China.
Li K; Medical Isotopes Research Center and Department of Radiation Medicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China.
Zhou S; Department of Cell Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China.
Zhu H; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing, 100142, China. .; NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Peking University Cancer Hospital & Institute, Beijing, 100142, China. .
Yang Z; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing, 100142, China. .; NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Peking University Cancer Hospital & Institute, Beijing, 100142, China. .
Liu Z; Medical Isotopes Research Center and Department of Radiation Medicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China. .; NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Peking University Cancer Hospital & Institute, Beijing, 100142, China. .
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Źródło:
Journal of nanobiotechnology [J Nanobiotechnology] 2021 Jun 10; Vol. 19 (1), pp. 175. Date of Electronic Publication: 2021 Jun 10.
Typ publikacji:
Journal Article
MeSH Terms:
Combined Modality Therapy/*methods
Immunotherapy, Adoptive/*methods
Positron-Emission Tomography/*methods
T-Lymphocytes, Cytotoxic/*drug effects
T-Lymphocytes, Cytotoxic/*pathology
Adoptive Transfer ; Animals ; Antineoplastic Agents ; Cell Line, Tumor ; Disease Models, Animal ; Female ; Humans ; Melanoma, Experimental ; Mice ; Mice, Inbred C57BL ; Ovalbumin ; Tumor Microenvironment
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
T cell circuits that sense antigen density with an ultrasensitive threshold.
Autorzy:
Hernandez-Lopez RA; Cell Design Institute, Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA.; Center for Cellular Construction, University of California San Francisco, San Francisco, CA, USA.
Yu W; Cell Design Institute, Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA.
Cabral KA; Center for Cellular Construction, University of California San Francisco, San Francisco, CA, USA.; Department of Pharmaceutical Chemistry, Chan Zuckerberg BioHub, University of California San Francisco, San Francisco, CA, USA.; Graduate Program in Bioengineering, University of California Berkeley and University of California San Francisco, San Francisco, CA, USA.
Creasey OA; Center for Cellular Construction, University of California San Francisco, San Francisco, CA, USA.; Department of Pharmaceutical Chemistry, Chan Zuckerberg BioHub, University of California San Francisco, San Francisco, CA, USA.; Graduate Program in Bioengineering, University of California Berkeley and University of California San Francisco, San Francisco, CA, USA.
Lopez Pazmino MDP; Cell Design Institute, Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA.; Center for Cellular Construction, University of California San Francisco, San Francisco, CA, USA.
Tonai Y; Cell Design Institute, Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA.
De Guzman A; Cell Design Institute, Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA.
Mäkelä A; Department of Virology, Haartman Institute, University of Helsinki, Helsinki, Finland.
Saksela K; Department of Virology, Haartman Institute, University of Helsinki, Helsinki, Finland.
Gartner ZJ; Center for Cellular Construction, University of California San Francisco, San Francisco, CA, USA.; Department of Pharmaceutical Chemistry, Chan Zuckerberg BioHub, University of California San Francisco, San Francisco, CA, USA.
Lim WA; Cell Design Institute, Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA. .; Center for Cellular Construction, University of California San Francisco, San Francisco, CA, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2021 Mar 12; Vol. 371 (6534), pp. 1166-1171. Date of Electronic Publication: 2021 Feb 25.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Cell Engineering*
Receptors, Chimeric Antigen/*immunology
T-Lymphocytes, Cytotoxic/*immunology
T-Lymphocytes, Cytotoxic/*metabolism
Animals ; Antigens, Neoplasm/immunology ; Cell Line, Tumor ; Humans ; Immunotherapy, Adoptive ; K562 Cells ; Mice ; Receptor, ErbB-2/genetics ; Receptor, ErbB-2/immunology ; Receptor, ErbB-2/metabolism ; Receptors, Artificial/metabolism ; Receptors, Chimeric Antigen/genetics ; Receptors, Chimeric Antigen/metabolism ; Receptors, Notch/genetics ; Receptors, Notch/metabolism ; Spheroids, Cellular ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Peptidoglycan-treated tumor antigen-pulsed dendritic cells impart complete resistance against tumor rechallenge.
Autorzy:
Patidar A; National Centre for Cell Science, Pune, India.
Selvaraj S; National Centre for Cell Science, Pune, India.
Chauhan P; National Centre for Cell Science, Pune, India.
Guzman CA; Helmholtz Centre for Infection Research (HZI), Braunschweig, Germany.
Ebensen T; Helmholtz Centre for Infection Research (HZI), Braunschweig, Germany.
Sarkar A; Trident Academy of Creative Technology, Bhubaneswar, India.
Chattopadhyay D; National Institute of Traditional Medicine, Belagavi, India.
Saha B; National Centre for Cell Science, Pune, India.; Trident Academy of Creative Technology, Bhubaneswar, India.; National Institute of Traditional Medicine, Belagavi, India.
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Źródło:
Clinical and experimental immunology [Clin Exp Immunol] 2020 Sep; Vol. 201 (3), pp. 279-288. Date of Electronic Publication: 2020 Jun 26.
Typ publikacji:
Journal Article
MeSH Terms:
Cancer Vaccines/*immunology
Dendritic Cells/*immunology
Immunotherapy, Adoptive/*methods
Prostatic Neoplasms/*immunology
T-Lymphocytes, Cytotoxic/*immunology
Animals ; Antigens, Neoplasm/immunology ; Antigens, Neoplasm/metabolism ; Cytokines/metabolism ; Dendritic Cells/transplantation ; Disease Models, Animal ; Humans ; Inflammation Mediators/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Neoplasm Recurrence, Local ; Peptidoglycan/metabolism ; Toll-Like Receptor 2/agonists ; Tumor Burden
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Dendritic Cells Therapy with Cytokine-Induced Killer Cells and Activated Cytotoxic T Cells Attenuated Th2 Bias Immune Response.
Autorzy:
Li C; Qingdao Central Hospital, The Second Clinical Hospital of Qingdao University , Qingdao, China.; Cancer Biotherapy Center of Qingdao Key Lab , Qingdao, China.
Zhu D; Qingdao Central Hospital, The Second Clinical Hospital of Qingdao University , Qingdao, China.; Cancer Biotherapy Center of Qingdao Key Lab , Qingdao, China.
Zhao Y; Qingdao Central Hospital, The Second Clinical Hospital of Qingdao University , Qingdao, China.
Guo Q; Qingdao Central Hospital, The Second Clinical Hospital of Qingdao University , Qingdao, China.; Cancer Biotherapy Center of Qingdao Key Lab , Qingdao, China.
Sun W; Qingdao Central Hospital, The Second Clinical Hospital of Qingdao University , Qingdao, China.; Cancer Biotherapy Center of Qingdao Key Lab , Qingdao, China.
Li L; Queen Mary School, Medical college of Nanchang University , Nanchang, China.
Gao D; Qingdao Central Hospital, The Second Clinical Hospital of Qingdao University , Qingdao, China.; Cancer Biotherapy Center of Qingdao Key Lab , Qingdao, China.
Zhao P; Qingdao Central Hospital, The Second Clinical Hospital of Qingdao University , Qingdao, China.; Cancer Biotherapy Center of Qingdao Key Lab , Qingdao, China.
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Źródło:
Immunological investigations [Immunol Invest] 2020 Jul; Vol. 49 (5), pp. 522-534. Date of Electronic Publication: 2019 Dec 03.
Typ publikacji:
Journal Article
MeSH Terms:
Cancer Vaccines/*immunology
Cytokine-Induced Killer Cells/*immunology
Dendritic Cells/*immunology
Immunotherapy, Adoptive/*methods
Neoplasms/*therapy
T-Lymphocytes, Cytotoxic/*immunology
Th2 Cells/*immunology
Adult ; Aged ; Aged, 80 and over ; Cells, Cultured ; Cytokine-Induced Killer Cells/transplantation ; Dendritic Cells/transplantation ; Female ; Humans ; Immunity ; Lymphocyte Activation ; Male ; Middle Aged ; Neoplasms/immunology ; T-Lymphocytes, Cytotoxic/transplantation ; Th1-Th2 Balance ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The DNA methyltransferase inhibitor, guadecitabine, targets tumor-induced myelopoiesis and recovers T cell activity to slow tumor growth in combination with adoptive immunotherapy in a mouse model of breast cancer.
Autorzy:
Luker AJ; Department of Microbiology and Immunology, School of Medicine, VCU, Box 980678, Richmond, VA, 23298, USA.; Massey Cancer Center, VCU, Box 980678, Richmond, VA, 23298, USA.
Graham LJ; Department of Microbiology and Immunology, School of Medicine, VCU, Box 980678, Richmond, VA, 23298, USA.; Massey Cancer Center, VCU, Box 980678, Richmond, VA, 23298, USA.
Smith TM Jr; Department of Microbiology and Immunology, School of Medicine, VCU, Box 980678, Richmond, VA, 23298, USA.; Massey Cancer Center, VCU, Box 980678, Richmond, VA, 23298, USA.
Camarena C; Department of Microbiology and Immunology, School of Medicine, VCU, Box 980678, Richmond, VA, 23298, USA.
Zellner MP; Department of Microbiology and Immunology, School of Medicine, VCU, Box 980678, Richmond, VA, 23298, USA.
Gilmer JS; Department of Biology, College of Humanities and Sciences, VCU, Richmond, VA, USA.
Damle SR; Department of Microbiology and Immunology, School of Medicine, VCU, Box 980678, Richmond, VA, 23298, USA.; Massey Cancer Center, VCU, Box 980678, Richmond, VA, 23298, USA.
Conrad DH; Department of Microbiology and Immunology, School of Medicine, VCU, Box 980678, Richmond, VA, 23298, USA.; Massey Cancer Center, VCU, Box 980678, Richmond, VA, 23298, USA.
Bear HD; Department of Microbiology and Immunology, School of Medicine, VCU, Box 980678, Richmond, VA, 23298, USA.; Massey Cancer Center, VCU, Box 980678, Richmond, VA, 23298, USA.; Division of Surgical Oncology, Department of Surgery, VCU, Richmond, VA, USA.
Martin RK; Department of Microbiology and Immunology, School of Medicine, VCU, Box 980678, Richmond, VA, 23298, USA. .; Massey Cancer Center, VCU, Box 980678, Richmond, VA, 23298, USA. .
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Źródło:
BMC immunology [BMC Immunol] 2020 Feb 27; Vol. 21 (1), pp. 8. Date of Electronic Publication: 2020 Feb 27.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Agents/*therapeutic use
Azacitidine/*analogs & derivatives
Breast Neoplasms/*therapy
Immunotherapy, Adoptive/*methods
Myeloid-Derived Suppressor Cells/*immunology
T-Lymphocytes, Cytotoxic/*immunology
Animals ; Azacitidine/therapeutic use ; Breast Neoplasms/immunology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Combined Modality Therapy ; DNA Modification Methylases/antagonists & inhibitors ; Female ; Humans ; Lymphocyte Activation ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Myelopoiesis/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Direct comparison of target-reactivity and cross-reactivity induced by CAR- and BiTE-redirected T cells for the development of antibody-based T-cell therapy.
Autorzy:
Maruta M; Department of Hematology, Clinical Immunology, and Infectious Diseases, Ehime University Graduate School of Medicine, 791-0295, Toon, Ehime, Japan.
Ochi T; Department of Hematology, Clinical Immunology, and Infectious Diseases, Ehime University Graduate School of Medicine, 791-0295, Toon, Ehime, Japan. .; Division of Immune Regulation, Proteo-Science Center, Ehime University, 791-0295, Toon, Ehime, Japan. .
Tanimoto K; Department of Hematology, Clinical Immunology, and Infectious Diseases, Ehime University Graduate School of Medicine, 791-0295, Toon, Ehime, Japan.
Asai H; Department of Hematology, Clinical Immunology, and Infectious Diseases, Ehime University Graduate School of Medicine, 791-0295, Toon, Ehime, Japan.
Saitou T; Department of Molecular Medicine for Pathogenesis, Ehime University Graduate School of Medicine, 791-0295, Toon, Ehime, Japan.
Fujiwara H; Department of Hematology, Clinical Immunology, and Infectious Diseases, Ehime University Graduate School of Medicine, 791-0295, Toon, Ehime, Japan.
Imamura T; Department of Molecular Medicine for Pathogenesis, Ehime University Graduate School of Medicine, 791-0295, Toon, Ehime, Japan.
Takenaka K; Department of Hematology, Clinical Immunology, and Infectious Diseases, Ehime University Graduate School of Medicine, 791-0295, Toon, Ehime, Japan.
Yasukawa M; Division of Immune Regulation, Proteo-Science Center, Ehime University, 791-0295, Toon, Ehime, Japan.
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Źródło:
Scientific reports [Sci Rep] 2019 Sep 16; Vol. 9 (1), pp. 13293. Date of Electronic Publication: 2019 Sep 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antigens, Neoplasm/*immunology
HLA-A2 Antigen/*immunology
Immunotherapy, Adoptive/*methods
Membrane Proteins/*immunology
Multiple Myeloma/*therapy
Receptors, Chimeric Antigen/*immunology
T-Lymphocytes, Cytotoxic/*transplantation
Cell Line, Tumor ; Humans ; Immunoglobulin Variable Region/immunology ; Lymphocyte Activation/immunology ; Multiple Myeloma/immunology ; T-Lymphocytes, Cytotoxic/immunology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The expansion of targetable biomarkers for CAR T cell therapy.
Autorzy:
Townsend MH; Department of Microbiology and Molecular Biology, Brigham Young University, 3142 LSB, Provo, UT, 84602, USA.
Shrestha G; Department of Microbiology and Molecular Biology, Brigham Young University, 3142 LSB, Provo, UT, 84602, USA.; Thunder Biotech, Highland, UT, USA.
Robison RA; Department of Microbiology and Molecular Biology, Brigham Young University, 3142 LSB, Provo, UT, 84602, USA.
O'Neill KL; Department of Microbiology and Molecular Biology, Brigham Young University, 3142 LSB, Provo, UT, 84602, USA. kim_.
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Źródło:
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2018 Jul 21; Vol. 37 (1), pp. 163. Date of Electronic Publication: 2018 Jul 21.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Biomarkers/*chemistry
Immunotherapy, Adoptive/*methods
T-Lymphocytes, Cytotoxic/*metabolism
Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Specific antitumour immunity of HIFU-activated cytotoxic T lymphocytes after adoptive transfusion in tumour-bearing mice.
Autorzy:
Ran LF; a Institute of Ultrasonic Engineering in Medicine, Chongqing Medical University , Chongqing , China and.
Xie XP; a Institute of Ultrasonic Engineering in Medicine, Chongqing Medical University , Chongqing , China and.
Xia JZ; a Institute of Ultrasonic Engineering in Medicine, Chongqing Medical University , Chongqing , China and.
Xie FL; a Institute of Ultrasonic Engineering in Medicine, Chongqing Medical University , Chongqing , China and.
Fan YM; a Institute of Ultrasonic Engineering in Medicine, Chongqing Medical University , Chongqing , China and.
Wu F; a Institute of Ultrasonic Engineering in Medicine, Chongqing Medical University , Chongqing , China and.; b Nuffield Department of Surgical Sciences, University of Oxford , Oxford , UK.
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Źródło:
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group [Int J Hyperthermia] 2016; Vol. 32 (2), pp. 204-10. Date of Electronic Publication: 2015 Dec 27.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
High-Intensity Focused Ultrasound Ablation*
Immunotherapy, Adoptive*
Neoplasms/*therapy
T-Lymphocytes, Cytotoxic/*immunology
Animals ; Cell Line, Tumor ; Female ; Mice ; Mice, Inbred C57BL ; Neoplasms/immunology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Chimeric Antigen Receptor T Cell Therapy in Hematology.
Autorzy:
Ataca P; Ankara University Faculty of Medicine, Department of Hematology, Ankara, Turkey E-mail: .
Arslan Ö
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Źródło:
Turkish journal of haematology : official journal of Turkish Society of Haematology [Turk J Haematol] 2015 Dec; Vol. 32 (4), pp. 285-94. Date of Electronic Publication: 2015 Aug 06.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Immunotherapy, Adoptive*/adverse effects
Melanoma/*therapy
Neoplasms/*therapy
Receptors, Antigen, T-Cell/*immunology
T-Lymphocytes, Cytotoxic/*transplantation
Antigens, Neoplasm/immunology ; CD3 Complex/genetics ; CD3 Complex/immunology ; Clinical Trials as Topic ; Costimulatory and Inhibitory T-Cell Receptors/genetics ; Costimulatory and Inhibitory T-Cell Receptors/immunology ; Cytokines/metabolism ; Cytotoxicity, Immunologic ; Genetic Engineering/methods ; Genetic Engineering/standards ; Hematologic Neoplasms/immunology ; Hematologic Neoplasms/therapy ; Humans ; Melanoma/immunology ; Neoplasms/immunology ; Receptors, Antigen, T-Cell/genetics ; Receptors, Antigen, T-Cell, alpha-beta/genetics ; Receptors, Antigen, T-Cell, alpha-beta/immunology ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/immunology ; Salvage Therapy ; Systemic Inflammatory Response Syndrome/etiology ; Systemic Inflammatory Response Syndrome/physiopathology ; T-Cell Antigen Receptor Specificity ; T-Lymphocytes, Cytotoxic/immunology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Adoptive immunotherapy with MUC1-mRNA transfected dendritic cells and cytotoxic lymphocytes plus gemcitabine for unresectable pancreatic cancer.
Autorzy:
Shindo Y
Hazama S
Maeda Y
Matsui H
Iida M
Suzuki N
Yoshimura K
Ueno T
Yoshino S
Sakai K
Suehiro Y
Yamasaki T
Hinoda Y
Oka M; Department of Digestive Surgery and Surgical Oncology (Department of Surgery II), Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-kogushi, Ube, Yamaguchi 755-8505, Japan. .
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Źródło:
Journal of translational medicine [J Transl Med] 2014 Jun 19; Vol. 12, pp. 175. Date of Electronic Publication: 2014 Jun 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Immunotherapy, Adoptive*
Antimetabolites, Antineoplastic/*therapeutic use
Dendritic Cells/*immunology
Deoxycytidine/*analogs & derivatives
Mucin-1/*genetics
Pancreatic Neoplasms/*therapy
RNA, Messenger/*genetics
T-Lymphocytes, Cytotoxic/*immunology
Adult ; Aged ; Combined Modality Therapy ; Cytotoxicity, Immunologic ; Deoxycytidine/therapeutic use ; Female ; Humans ; Male ; Middle Aged ; Pancreatic Neoplasms/drug therapy ; Transfection ; Gemcitabine
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
RNA-transfection of γ/δ T cells with a chimeric antigen receptor or an α/β T-cell receptor: a safer alternative to genetically engineered α/β T cells for the immunotherapy of melanoma.
Autorzy:
Harrer DC; Department of Dermatology, Universitätsklinikum Erlangen, Hartmannstraße 14, D-91052, Erlangen, Germany.; Department of Dermatology, Faculty of Medicine, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.
Simon B; Department of Dermatology, Universitätsklinikum Erlangen, Hartmannstraße 14, D-91052, Erlangen, Germany.; Department of Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg Erlangen-Nürnberg, Erlangen, Germany.
Fujii SI; Laboratory for Immunotherapy, RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan.
Shimizu K; Laboratory for Immunotherapy, RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan.
Uslu U; Department of Dermatology, Universitätsklinikum Erlangen, Hartmannstraße 14, D-91052, Erlangen, Germany.
Schuler G; Department of Dermatology, Universitätsklinikum Erlangen, Hartmannstraße 14, D-91052, Erlangen, Germany.; Department of Dermatology, Faculty of Medicine, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.
Gerer KF; Department of Dermatology, Universitätsklinikum Erlangen, Hartmannstraße 14, D-91052, Erlangen, Germany.; Department of Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg Erlangen-Nürnberg, Erlangen, Germany.
Hoyer S; Department of Dermatology, Universitätsklinikum Erlangen, Hartmannstraße 14, D-91052, Erlangen, Germany.
Dörrie J; Department of Dermatology, Universitätsklinikum Erlangen, Hartmannstraße 14, D-91052, Erlangen, Germany.; Department of Dermatology, Faculty of Medicine, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.
Schaft N; Department of Dermatology, Universitätsklinikum Erlangen, Hartmannstraße 14, D-91052, Erlangen, Germany. .; Department of Dermatology, Faculty of Medicine, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany. .
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Źródło:
BMC cancer [BMC Cancer] 2017 Aug 17; Vol. 17 (1), pp. 551. Date of Electronic Publication: 2017 Aug 17.
Typ publikacji:
Journal Article
MeSH Terms:
RNA*
Receptors, Antigen, T-Cell/*genetics
Receptors, Antigen, T-Cell, alpha-beta/*genetics
Recombinant Fusion Proteins/*genetics
T-Lymphocytes, Cytotoxic/*immunology
T-Lymphocytes, Cytotoxic/*metabolism
Adult ; Cell Culture Techniques ; Cytokines/metabolism ; Cytotoxicity, Immunologic ; Electroporation ; Genetic Engineering ; HLA-A2 Antigen/immunology ; Healthy Volunteers ; Humans ; Immunomagnetic Separation ; Immunophenotyping ; Immunotherapy, Adoptive ; Melanoma/genetics ; Melanoma/immunology ; Melanoma/metabolism ; Melanoma/therapy ; Middle Aged ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Receptors, Antigen, T-Cell/metabolism ; Receptors, Antigen, T-Cell, alpha-beta/metabolism ; T-Cell Antigen Receptor Specificity ; Transfection ; Young Adult ; gp100 Melanoma Antigen/immunology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Suppression of murine tumour growth through CD8 dendritic cells by sequential administration of α-galactosylceramide in vivo.
Autorzy:
Kogo H; Department of Microbiology and Immunology, Nippon Medical School, Tokyo, Japan.; Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Nippon Medical School, Tokyo, Japan.
Shimizu M; Department of Microbiology and Immunology, Nippon Medical School, Tokyo, Japan.
Negishi Y; Department of Microbiology and Immunology, Nippon Medical School, Tokyo, Japan.
Uchida E; Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Nippon Medical School, Tokyo, Japan.
Takahashi H; Department of Microbiology and Immunology, Nippon Medical School, Tokyo, Japan.
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Źródło:
Immunology [Immunology] 2017 Jul; Vol. 151 (3), pp. 324-339. Date of Electronic Publication: 2017 Apr 18.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Carcinoma, Hepatocellular/*therapy
Dendritic Cells/*drug effects
Galactosylceramides/*administration & dosage
Immunologic Factors/*administration & dosage
Immunotherapy/*methods
Liver Neoplasms/*therapy
Lymphocyte Activation/*drug effects
Lymphocytes, Tumor-Infiltrating/*drug effects
T-Lymphocytes, Cytotoxic/*drug effects
Tumor Burden/*drug effects
Animals ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/immunology ; Carcinoma, Hepatocellular/pathology ; Cell Communication/drug effects ; Cell Line, Tumor ; Cross-Priming/drug effects ; Dendritic Cells/immunology ; Female ; Genotype ; Immunotherapy, Adoptive ; Liver Neoplasms/genetics ; Liver Neoplasms/immunology ; Liver Neoplasms/pathology ; Lymphocytes, Tumor-Infiltrating/immunology ; Lymphocytes, Tumor-Infiltrating/transplantation ; Mice, Inbred C57BL ; Mice, Knockout ; Natural Killer T-Cells/drug effects ; Natural Killer T-Cells/immunology ; Phenotype ; T-Lymphocytes, Cytotoxic/immunology ; T-Lymphocytes, Cytotoxic/transplantation ; Time Factors ; Tumor Microenvironment
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Generation of populations of antigen-specific cytotoxic T cells using DCs transfected with DNA construct encoding HER2/neu tumor antigen epitopes.
Autorzy:
Kuznetsova M; Federal State Budgetary Scientific Institution 'Research Institute of Fundamental and Clinical Immunology', Yadrintsevskaya str., 14, Novosibirsk, 630099, Russia.
Lopatnikova J; Federal State Budgetary Scientific Institution 'Research Institute of Fundamental and Clinical Immunology', Yadrintsevskaya str., 14, Novosibirsk, 630099, Russia.
Khantakova J; Federal State Budgetary Scientific Institution 'Research Institute of Fundamental and Clinical Immunology', Yadrintsevskaya str., 14, Novosibirsk, 630099, Russia.
Maksyutov R; State Research Center of Virology and Biotechnology 'VECTOR', Koltsovo, Novosibirsk Region, 630559, Russia.
Maksyutov A; Federal State Budgetary Scientific Institution 'Research Institute of Fundamental and Clinical Immunology', Yadrintsevskaya str., 14, Novosibirsk, 630099, Russia.; State Research Center of Virology and Biotechnology 'VECTOR', Koltsovo, Novosibirsk Region, 630559, Russia.
Sennikov S; Federal State Budgetary Scientific Institution 'Research Institute of Fundamental and Clinical Immunology', Yadrintsevskaya str., 14, Novosibirsk, 630099, Russia. .
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Źródło:
BMC immunology [BMC Immunol] 2017 Jun 20; Vol. 18 (1), pp. 31. Date of Electronic Publication: 2017 Jun 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Adenocarcinoma/*immunology
Breast Neoplasms/*immunology
Cancer Vaccines/*immunology
Dendritic Cells/*immunology
Immunotherapy, Adoptive/*methods
Receptor, ErbB-2/*metabolism
T-Lymphocytes, Cytotoxic/*immunology
Adenocarcinoma/therapy ; Breast Neoplasms/therapy ; Epitopes/genetics ; Female ; HLA-A2 Antigen/metabolism ; Humans ; Lymphocyte Activation ; MCF-7 Cells ; Neoplasm Metastasis ; Peptide Fragments/genetics ; Receptor, ErbB-2/genetics ; T-Lymphocytes, Cytotoxic/transplantation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Improving the in vivo persistence, distribution and function of cytotoxic T lymphocytes by inhibiting the tumor immunosuppressive microenvironment.
Autorzy:
Xu W; Department of Pediatric Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Cai J
Li S
Zhang H
Han J
Wen M
Wen J
Gao F
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Źródło:
Scandinavian journal of immunology [Scand J Immunol] 2013 Jul; Vol. 78 (1), pp. 50-60.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Immune Tolerance*
Immunotherapy, Adoptive*
Tumor Microenvironment*
Neoplasms, Experimental/*therapy
T-Lymphocytes, Cytotoxic/*immunology
Animals ; Cell Cycle ; Cell Line, Tumor ; Cell Movement ; Cyclophosphamide/pharmacology ; Cytokines/blood ; Mice ; Mice, Inbred C57BL ; Neoplasms, Experimental/immunology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A hybrid of B and T lymphoblastic cell line could potentially substitute dendritic cells to efficiently expand out Her-2/neu-specific cytotoxic T lymphocytes from advanced breast cancer patients in vitro.
Autorzy:
Chen S; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Gu F; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Li K; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Zhang K; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Liu Y; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Liang J; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Gao W; Traumatology Department, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Wu G; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Liu L; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. .
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Źródło:
Journal of hematology & oncology [J Hematol Oncol] 2017 Feb 28; Vol. 10 (1), pp. 63. Date of Electronic Publication: 2017 Feb 28.
Typ publikacji:
Letter; Research Support, Non-U.S. Gov't
MeSH Terms:
Breast Neoplasms/*therapy
Immunotherapy, Adoptive/*methods
Receptor, ErbB-2/*immunology
T-Lymphocytes, Cytotoxic/*transplantation
Antigens, Neoplasm/immunology ; Breast Neoplasms/immunology ; Cell Culture Techniques/methods ; Cell Line, Tumor ; Cell Proliferation ; Dendritic Cells ; Female ; Humans ; T-Lymphocytes, Cytotoxic/cytology ; T-Lymphocytes, Cytotoxic/immunology
Raport
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
An oxygen sensitive self-decision making engineered CAR T-cell.
Autorzy:
Juillerat A; Cellectis Inc, 430E, 29th street, NYC, NY 10016, USA.
Marechal A; Cellectis, 8 rue de la croix Jarry, 75013, Paris.
Filhol JM; Cellectis, 8 rue de la croix Jarry, 75013, Paris.
Valogne Y; Cellectis, 8 rue de la croix Jarry, 75013, Paris.
Valton J; Cellectis Inc, 430E, 29th street, NYC, NY 10016, USA.
Duclert A; Cellectis, 8 rue de la croix Jarry, 75013, Paris.
Duchateau P; Cellectis, 8 rue de la croix Jarry, 75013, Paris.
Poirot L; Cellectis, 8 rue de la croix Jarry, 75013, Paris.
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Źródło:
Scientific reports [Sci Rep] 2017 Jan 20; Vol. 7, pp. 39833. Date of Electronic Publication: 2017 Jan 20.
Typ publikacji:
Journal Article
MeSH Terms:
Hypoxia-Inducible Factor 1, alpha Subunit/*genetics
Immunotherapy, Adoptive/*methods
Neoplasms/*therapy
Oxygen/*metabolism
Receptors, Antigen, T-Cell/*genetics
Recombinant Fusion Proteins/*genetics
T-Lymphocytes, Cytotoxic/*physiology
Antigens, Neoplasm/immunology ; Cell Line, Tumor ; Cytotoxicity, Immunologic ; Genetic Engineering ; Humans ; Lymphocyte Activation ; Neoplasms/immunology ; T-Cell Antigen Receptor Specificity ; T-Lymphocytes, Cytotoxic/transplantation ; Tumor Microenvironment
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Genetically Modified T-Cell-Based Adoptive Immunotherapy in Hematological Malignancies.
Autorzy:
Ye B; Department of Hematology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China.
Stary CM; Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94305-5117, USA.
Gao Q; Department of Hematology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China.
Wang Q; Department of Hematology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China.
Zeng Z; Department of Pathology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China.
Jian Z; Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China.
Gu L; Central Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China.
Xiong X; Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China; Central Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China.
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Źródło:
Journal of immunology research [J Immunol Res] 2017; Vol. 2017, pp. 5210459. Date of Electronic Publication: 2017 Jan 02.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Hematologic Neoplasms/*therapy
Immunotherapy, Adoptive/*methods
Receptors, Antigen, T-Cell/*genetics
T-Lymphocytes, Cytotoxic/*transplantation
Animals ; Antigens, Neoplasm/immunology ; Genetic Therapy ; Hematologic Neoplasms/immunology ; Humans ; Recombinant Fusion Proteins/genetics ; T-Lymphocytes, Cytotoxic/immunology ; Tumor Escape
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Repeated cycles of 5-fluorouracil chemotherapy impaired anti-tumor functions of cytotoxic T cells in a CT26 tumor-bearing mouse model.
Autorzy:
Wu Y; Department of Immunology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China.
Deng Z; Department of Immunology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China.
Wang H; Department of Immunology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China.; Department of Blood Transfusion, Anhui Provincial Hospital, Hefei, People's Republic of China.
Ma W; Department of Immunology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China.
Zhou C; Department of Immunology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China.
Zhang S; Department of Immunology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China. .
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Źródło:
BMC immunology [BMC Immunol] 2016 Sep 20; Vol. 17 (1), pp. 29. Date of Electronic Publication: 2016 Sep 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antibodies, Monoclonal/*therapeutic use
Antineoplastic Agents/*therapeutic use
Colonic Neoplasms/*therapy
Cytokine-Induced Killer Cells/*immunology
Fluorouracil/*therapeutic use
Immunotherapy, Adoptive/*methods
T-Lymphocytes, Cytotoxic/*immunology
Animals ; B7-H1 Antigen/immunology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Colonic Neoplasms/immunology ; Combined Modality Therapy ; Cytokine-Induced Killer Cells/transplantation ; Cytotoxicity, Immunologic/drug effects ; Humans ; Interferon-gamma/metabolism ; Male ; Mice ; Mice, Inbred BALB C ; Neoplasm Transplantation ; T-Lymphocytes, Cytotoxic/drug effects ; Transforming Growth Factor beta/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 108

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