Temat: "Immunotherapy, Adoptive" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Modulating Cholesterol Metabolism via ACAT1 Knockdown Enhances Anti-B-Cell Lymphoma Activities of CD19-Specific Chimeric Antigen Receptor T Cells by Improving the Cell Activation and Proliferation.
Autorzy:: Su Q; Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai 200241, China.
Yao J; Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai 200241, China.
Farooq MA; Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai 200241, China.
Ajmal I; Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai 200241, China.
Duan Y; Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai 200241, China.
He C; Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai 200241, China.
Hu X; Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai 200241, China.
Jiang W; Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai 200241, China.; Pokaż więcej
Źródło:: Cells [Cells] 2024 Mar 21; Vol. 13 (6). Date of Electronic Publication: 2024 Mar 21.
Typ publikacji:: Journal Article
MeSH Terms:: T-Lymphocytes*
Lymphoma, B-Cell*/pathology
Receptors, Antigen, T-Cell*
Animals ; Mice ; Acetyltransferases ; Immunotherapy, Adoptive ; Antibodies ; Cell Proliferation ; RNA, Small Interfering

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Skocz do pozycji: 2.

Tytuł:: Making drugs from T cells: The quantitative pharmacology of engineered T cell therapeutics.
Autorzy:: Kirouac DC; Notch Therapeutics, Vancouver, BC, Canada. .; The University of British Columbia, School of Biomedical Engineering, Vancouver, BC, Canada. .; Metrum Research Group, Tariffville, CT, USA. .
Zmurchok C; Notch Therapeutics, Vancouver, BC, Canada.
Morris D; Emerald City Pharma Consulting, Blaine, WA, USA.; Pokaż więcej
Źródło:: NPJ systems biology and applications [NPJ Syst Biol Appl] 2024 Mar 18; Vol. 10 (1), pp. 31. Date of Electronic Publication: 2024 Mar 18.
Typ publikacji:: Journal Article
MeSH Terms:: T-Lymphocytes*
Receptors, Antigen, T-Cell*
Humans ; Immunotherapy, Adoptive

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Skocz do pozycji: 3.

Tytuł:: CD19/CD20 dual-targeted chimeric antigen receptor-engineered natural killer cells exhibit improved cytotoxicity against acute lymphoblastic leukemia.
Autorzy:: Yang N; Tissue Engineering and Stem Cell Experiment Center, Guizhou Medical University (GMU), Guiyang, Guizhou, China.; Department of Immunology, College of Basic Medical Sciences, Guizhou Medical University, Guiyang, Guizhou, China.
Zhang C; Tissue Engineering and Stem Cell Experiment Center, Guizhou Medical University (GMU), Guiyang, Guizhou, China.
Zhang Y; Department of Biology, School of Basic Medical Sciences, Guizhou Medical University, Guiyang, Guizhou, China.
Fan Y; Tissue Engineering and Stem Cell Experiment Center, Guizhou Medical University (GMU), Guiyang, Guizhou, China.; Department of Immunology, College of Basic Medical Sciences, Guizhou Medical University, Guiyang, Guizhou, China.
Zhang J; Department of Biology, School of Basic Medical Sciences, Guizhou Medical University, Guiyang, Guizhou, China.
Lin X; Tissue Engineering and Stem Cell Experiment Center, Guizhou Medical University (GMU), Guiyang, Guizhou, China.; Department of Biology, School of Basic Medical Sciences, Guizhou Medical University, Guiyang, Guizhou, China.
Guo T; Department of Gynecology, the Affiliated Hospital of Guizhou Medical University, Guiyang, China.
Gu Y; State Key Laboratory of Biotherapy and Cancer Center, Sichuan University, Chengdu, China.
Wu J; Department of Immunology, College of Basic Medical Sciences, Guizhou Medical University, Guiyang, Guizhou, China.
Gao J; School of Pharmacy, Zunyi Medical University, Zunyi, China.
Zhao X; Tissue Engineering and Stem Cell Experiment Center, Guizhou Medical University (GMU), Guiyang, Guizhou, China. .; Department of Immunology, College of Basic Medical Sciences, Guizhou Medical University, Guiyang, Guizhou, China. .; Department of Biology, School of Basic Medical Sciences, Guizhou Medical University, Guiyang, Guizhou, China. .
He Z; Tissue Engineering and Stem Cell Experiment Center, Guizhou Medical University (GMU), Guiyang, Guizhou, China. .; Department of Immunology, College of Basic Medical Sciences, Guizhou Medical University, Guiyang, Guizhou, China. .; Key Laboratory of Adult Stem Cell Translational Research, Chinese Academy of Medical Sciences), Guiyang, China. .; Department of Pediatrics, the Affiliated Hospital of Zunyi Medical University, Zunyi, China. .; Pokaż więcej
Źródło:: Journal of translational medicine [J Transl Med] 2024 Mar 13; Vol. 22 (1), pp. 274. Date of Electronic Publication: 2024 Mar 13.
Typ publikacji:: Journal Article
MeSH Terms:: Receptors, Chimeric Antigen*/metabolism
Precursor Cell Lymphoblastic Leukemia-Lymphoma*/metabolism
Mice ; Animals ; Antigens, CD19/genetics ; Antigens, CD19/metabolism ; Cytotoxicity, Immunologic/genetics ; Cell Line, Tumor ; Killer Cells, Natural ; Immunotherapy, Adoptive ; RNA, Messenger/metabolism

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Skocz do pozycji: 4.

Tytuł:: CAR T cells and T cells phenotype and function are impacted by glucocorticoid exposure with different magnitude.
Autorzy:: Poiret T; Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden. .
Vikberg S; Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
Schoutrop E; Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
Mattsson J; Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.; Gloria and Seymour Epstein Chair in Cell Therapy and Transplantation, Princess Margaret Cancer Centre and University of Toronto; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Magalhaes I; Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.; Department of Immunology and Transfusion Medicine, Karolinska University Hospital, Stockholm, Sweden.; Pokaż więcej
Źródło:: Journal of translational medicine [J Transl Med] 2024 Mar 12; Vol. 22 (1), pp. 273. Date of Electronic Publication: 2024 Mar 12.
Typ publikacji:: Journal Article
MeSH Terms:: T-Lymphocytes*
Receptors, Chimeric Antigen*/metabolism
Glucocorticoids ; Programmed Cell Death 1 Receptor/metabolism ; Immunotherapy, Adoptive ; Phenotype ; Antigens, CD19/metabolism

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Skocz do pozycji: 5.

Tytuł:: The construction of modular universal chimeric antigen receptor T (MU-CAR-T) cells by covalent linkage of allogeneic T cells and various antibody fragments.
Autorzy:: Chen T; Institute of Human Virology, Department of Pathogen Biology and Biosecurity, Key Laboratory of Tropical Disease Control of Ministry Education, Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.; Guangzhou National Laboratory, Guangzhou International Bio-Island, Guangzhou, 510005, China.
Deng J; Institute of Human Virology, Department of Pathogen Biology and Biosecurity, Key Laboratory of Tropical Disease Control of Ministry Education, Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.
Zhang Y; Institute of Human Virology, Department of Pathogen Biology and Biosecurity, Key Laboratory of Tropical Disease Control of Ministry Education, Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.
Liu B; Institute of Human Virology, Department of Pathogen Biology and Biosecurity, Key Laboratory of Tropical Disease Control of Ministry Education, Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.
Liu R; Institute of Human Virology, Department of Pathogen Biology and Biosecurity, Key Laboratory of Tropical Disease Control of Ministry Education, Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.
Zhu Y; Institute of Human Virology, Department of Pathogen Biology and Biosecurity, Key Laboratory of Tropical Disease Control of Ministry Education, Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.; Guangzhou National Laboratory, Guangzhou International Bio-Island, Guangzhou, 510005, China.
Zhou M; Institute of Human Virology, Department of Pathogen Biology and Biosecurity, Key Laboratory of Tropical Disease Control of Ministry Education, Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.
Lin Y; Institute of Human Virology, Department of Pathogen Biology and Biosecurity, Key Laboratory of Tropical Disease Control of Ministry Education, Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.
Xia B; Institute of Human Virology, Department of Pathogen Biology and Biosecurity, Key Laboratory of Tropical Disease Control of Ministry Education, Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.
Lin K; Institute of Human Virology, Department of Pathogen Biology and Biosecurity, Key Laboratory of Tropical Disease Control of Ministry Education, Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.
Ma X; Guangzhou National Laboratory, Guangzhou International Bio-Island, Guangzhou, 510005, China. ma_.; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 511400, China. ma_.
Zhang H; Institute of Human Virology, Department of Pathogen Biology and Biosecurity, Key Laboratory of Tropical Disease Control of Ministry Education, Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China. .; Guangzhou National Laboratory, Guangzhou International Bio-Island, Guangzhou, 510005, China. .; Pokaż więcej
Źródło:: Molecular cancer [Mol Cancer] 2024 Mar 11; Vol. 23 (1), pp. 53. Date of Electronic Publication: 2024 Mar 11.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Receptors, Chimeric Antigen*/genetics
Receptors, Chimeric Antigen*/metabolism
Hematopoietic Stem Cell Transplantation*
Humans ; Immunoglobulin Fragments/metabolism ; T-Lymphocytes ; Receptors, Antigen, T-Cell/metabolism ; Immunotherapy, Adoptive/methods

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Skocz do pozycji: 6.

Tytuł:: Building a Better Defense: Expanding and Improving Natural Killer Cells for Adoptive Cell Therapy.
Autorzy:: Maia A; Molecular and Experimental Pathology Laboratory, Champalimaud Centre for the Unknown, Champalimaud Foundation, 1400-038 Lisbon, Portugal.; NK Cell Gene Manipulation and Therapy Laboratory, Division of Cellular Therapy and Stem Cell Transplant, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.; NOVA Medical School, NOVA University of Lisbon, 1099-085 Lisbon, Portugal.
Tarannum M; NK Cell Gene Manipulation and Therapy Laboratory, Division of Cellular Therapy and Stem Cell Transplant, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
Lérias JR; ImmunoTherapy/ImmunoSurgery, Champalimaud Centre for the Unknown, Champalimaud Foundation, 1400-038 Lisbon, Portugal.
Piccinelli S; NK Cell Gene Manipulation and Therapy Laboratory, Division of Cellular Therapy and Stem Cell Transplant, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
Borrego LM; Comprehensive Health Research Centre (CHRC), NOVA Medical School, Faculdade de Ciências Médicas (FCM), NOVA University of Lisbon, 1099-085 Lisbon, Portugal.; Immunoallergy Department, Hospital da Luz, 1600-209 Lisbon, Portugal.
Maeurer M; ImmunoTherapy/ImmunoSurgery, Champalimaud Centre for the Unknown, Champalimaud Foundation, 1400-038 Lisbon, Portugal.; I Medical Clinic, University of Mainz, 55131 Mainz, Germany.
Romee R; NK Cell Gene Manipulation and Therapy Laboratory, Division of Cellular Therapy and Stem Cell Transplant, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
Castillo-Martin M; Molecular and Experimental Pathology Laboratory, Champalimaud Centre for the Unknown, Champalimaud Foundation, 1400-038 Lisbon, Portugal.; Pathology Service, Champalimaud Clinical Center, Champalimaud Foundation, 1400-038 Lisbon, Portugal.; Pokaż więcej
Źródło:: Cells [Cells] 2024 Mar 05; Vol. 13 (5). Date of Electronic Publication: 2024 Mar 05.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Interleukin-15*
Receptors, Chimeric Antigen*/metabolism
Humans ; Immunotherapy, Adoptive/methods ; Killer Cells, Natural ; K562 Cells ; T-Lymphocytes ; Cytokines/metabolism

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Skocz do pozycji: 7.

Tytuł:: GMP-manufactured CRISPR/Cas9 technology as an advantageous tool to support cancer immunotherapy.
Autorzy:: Caforio M; U.O. Cellular and Genetic Therapy of Hematological Diseases, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Iacovelli S; U.O Officina Farmaceutica, Good Manufacturing Practice Facility, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Quintarelli C; U.O. Cellular and Genetic Therapy of Hematological Diseases, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Locatelli F; U.O. Cellular and Genetic Therapy of Hematological Diseases, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.; Department of Life Sciences and Public Health, Catholic University of the Sacred Heart, Rome, Italy.
Folgiero V; U.O. Cellular and Genetic Therapy of Hematological Diseases, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy. .; IRCCS Bambino Gesù Children's Hospital, Viale San Paolo 15, 00146, Rome, Italy. .; Pokaż więcej
Źródło:: Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2024 Mar 01; Vol. 43 (1), pp. 66. Date of Electronic Publication: 2024 Mar 01.
Typ publikacji:: Journal Article; Review
MeSH Terms:: CRISPR-Cas Systems*
Neoplasms*/genetics
Neoplasms*/therapy
Humans ; Gene Editing/methods ; Immunotherapy ; Immunotherapy, Adoptive

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Skocz do pozycji: 8.

Tytuł:: CAR‑T cell therapy: A breakthrough in traditional cancer treatment strategies (Review).
Autorzy:: Sun D; Department of General Surgery, Qianjiang Central Hospital, Qianjiang, Hubei 433100, P.R. China.
Shi X; Department of Pathology, Qianjiang Central Hospital, Qianjiang, Hubei 433100, P.R. China.
Li S; Department of Pathology, Qianjiang Central Hospital, Qianjiang, Hubei 433100, P.R. China.
Wang X; Department of Obstetrics, Qianjiang Central Hospital, Qianjiang, Hubei 433100, P.R. China.
Yang X; Department of General Surgery, Qianjiang Central Hospital, Qianjiang, Hubei 433100, P.R. China.
Wan M; Department of Traditional Chinese Medicine, Qianjiang Central Hospital, Qianjiang, Hubei 433100, P.R. China.; Pokaż więcej
Źródło:: Molecular medicine reports [Mol Med Rep] 2024 Mar; Vol. 29 (3). Date of Electronic Publication: 2024 Jan 26.
Typ publikacji:: Review; Journal Article
MeSH Terms:: Receptors, Chimeric Antigen*
Neoplasms*/pathology
Humans ; Receptors, Antigen, T-Cell/metabolism ; Immunotherapy, Adoptive ; T-Lymphocytes/metabolism

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Skocz do pozycji: 9.

Tytuł:: Indicators describing the tumor lesion aggregation and dissemination and their impact on the prognosis of patients with diffuse large B cell lymphoma receiving chimeric antigen receptor T cell therapy.
Autorzy:: Dang X; Department of Hematology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
Li P; Department of Hematology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
Shen A; Department of Medical Imaging, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
Lu Y; Department of Hematology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
Zhu Z; Department of Hematology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
Zhang M; Department of Hematology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
Qian W; Department of Hematology, the Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Liang A; Department of Hematology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
Zhang W; Department of Hematology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.; Pokaż więcej
Źródło:: Cancer medicine [Cancer Med] 2024 Mar; Vol. 13 (6), pp. e6991.
Typ publikacji:: Journal Article
MeSH Terms:: Receptors, Chimeric Antigen*/therapeutic use
Lymphoma, Large B-Cell, Diffuse*/drug therapy
Humans ; Immunotherapy, Adoptive/methods ; Positron Emission Tomography Computed Tomography ; Retrospective Studies ; Prognosis ; Cell- and Tissue-Based Therapy

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Skocz do pozycji: 10.

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Skocz do pozycji: 11.

Tytuł:: Unlocking Predictive Power: Quantitative Assessment of CAR-T Expansion with Digital Droplet Polymerase Chain Reaction (ddPCR).
Autorzy:: Galli E; Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli 8, 00168 Rome, Italy.
Viscovo M; Sezione di Ematologia, Dipartimento di Scienze Radiologiche ed Ematologiche, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Fosso F; Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli 8, 00168 Rome, Italy.
Pansini I; Sezione di Ematologia, Dipartimento di Scienze Radiologiche ed Ematologiche, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Di Cesare G; Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli 8, 00168 Rome, Italy.
Iacovelli C; Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli 8, 00168 Rome, Italy.
Maiolo E; Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli 8, 00168 Rome, Italy.
Sorà F; Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli 8, 00168 Rome, Italy.; Sezione di Ematologia, Dipartimento di Scienze Radiologiche ed Ematologiche, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Hohaus S; Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli 8, 00168 Rome, Italy.; Sezione di Ematologia, Dipartimento di Scienze Radiologiche ed Ematologiche, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Sica S; Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli 8, 00168 Rome, Italy.; Sezione di Ematologia, Dipartimento di Scienze Radiologiche ed Ematologiche, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Bellesi S; Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli 8, 00168 Rome, Italy.
Chiusolo P; Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli 8, 00168 Rome, Italy.; Sezione di Ematologia, Dipartimento di Scienze Radiologiche ed Ematologiche, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Feb 26; Vol. 25 (5). Date of Electronic Publication: 2024 Feb 26.
Typ publikacji:: Journal Article
MeSH Terms:: Receptors, Chimeric Antigen*
Lymphoma, Large B-Cell, Diffuse*/therapy
Humans ; Polymerase Chain Reaction/methods ; Treatment Outcome ; Progression-Free Survival ; Immunotherapy, Adoptive

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Skocz do pozycji: 12.

Tytuł:: Chimeric Antigen Receptor T Cell Therapy for Hepatocellular Carcinoma: Where Do We Stand?
Autorzy:: Aggeletopoulou I; Division of Gastroenterology, Department of Internal Medicine, University Hospital of Patras, 26504 Patras, Greece.
Kalafateli M; Department of Gastroenterology, General Hospital of Patras, 26332 Patras, Greece.
Triantos C; Division of Gastroenterology, Department of Internal Medicine, University Hospital of Patras, 26504 Patras, Greece.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Feb 23; Vol. 25 (5). Date of Electronic Publication: 2024 Feb 23.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Carcinoma, Hepatocellular*/pathology
Receptors, Chimeric Antigen*
Liver Neoplasms*/pathology
Humans ; Immunotherapy, Adoptive ; T-Lymphocytes ; Cell- and Tissue-Based Therapy ; Tumor Microenvironment

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Skocz do pozycji: 13.

Tytuł:: Harnessing the Transcriptional Signatures of CAR-T-Cells and Leukemia/Lymphoma Using Single-Cell Sequencing Technologies.
Autorzy:: Liao YM; Division of Hematology-Oncology, Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Hsu SH; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan.; Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.; Center of Applied Genomics, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Chiou SS; Division of Hematology-Oncology, Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan.; Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.; Center of Applied Genomics, Kaohsiung Medical University, Kaohsiung 807, Taiwan.; Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Feb 19; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 19.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Receptors, Chimeric Antigen*/genetics
Leukemia*/genetics
Leukemia*/therapy
Lymphoma*/etiology
Humans ; Receptors, Antigen, T-Cell/genetics ; T-Lymphocytes ; Immunotherapy, Adoptive/methods ; Tumor Microenvironment

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Skocz do pozycji: 14.

Tytuł:: Combined therapy of CAR-IL-15/IL-15Rα-T cells and GLIPR1 knockdown in cancer cells enhanced anti-tumor effect against gastric cancer.
Autorzy:: Ye J; School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, 510515, Guangdong, People's Republic of China.
Liu Q; School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, 510515, Guangdong, People's Republic of China.
He Y; School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, 510515, Guangdong, People's Republic of China.
Song Z; Shenzhen Beike Biotechnology Co., Ltd., Shenzhen, 518000, Guangdong, People's Republic of China.
Lin B; Shenzhen Beike Biotechnology Co., Ltd., Shenzhen, 518000, Guangdong, People's Republic of China.
Hu Z; Shenzhen Beike Biotechnology Co., Ltd., Shenzhen, 518000, Guangdong, People's Republic of China.
Hu J; Shenzhen Beike Biotechnology Co., Ltd., Shenzhen, 518000, Guangdong, People's Republic of China.
Ning Y; School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, 510515, Guangdong, People's Republic of China. .
Cai C; Shenzhen Beike Biotechnology Co., Ltd., Shenzhen, 518000, Guangdong, People's Republic of China. cheguo_.
Li Y; School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, 510515, Guangdong, People's Republic of China. .; Pokaż więcej
Źródło:: Journal of translational medicine [J Transl Med] 2024 Feb 18; Vol. 22 (1), pp. 171. Date of Electronic Publication: 2024 Feb 18.
Typ publikacji:: Journal Article
MeSH Terms:: Stomach Neoplasms*/genetics
Stomach Neoplasms*/therapy
Receptors, Chimeric Antigen*/genetics
Receptors, Chimeric Antigen*/metabolism
Humans ; Animals ; Mice ; Interleukin-15/genetics ; Interleukin-15/metabolism ; Cell Line, Tumor ; Neoplasm Recurrence, Local/metabolism ; Immunotherapy, Adoptive/methods ; T-Lymphocytes ; Xenograft Model Antitumor Assays ; Tumor Microenvironment ; Membrane Proteins/metabolism ; Neoplasm Proteins/metabolism ; Nerve Tissue Proteins/metabolism

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Skocz do pozycji: 15.

Tytuł:: IL-15-secreting CAR natural killer cells directed toward the pan-cancer target CD70 eliminate both cancer cells and cancer-associated fibroblasts.
Autorzy:: Van den Eynde A; Center for Oncological Research (CORE), Integrated Personalized and Precision Oncology Network (IPPON), Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium. .
Gehrcken L; Center for Oncological Research (CORE), Integrated Personalized and Precision Oncology Network (IPPON), Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium.
Verhezen T; Center for Oncological Research (CORE), Integrated Personalized and Precision Oncology Network (IPPON), Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium.
Lau HW; Center for Oncological Research (CORE), Integrated Personalized and Precision Oncology Network (IPPON), Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium.
Hermans C; Center for Oncological Research (CORE), Integrated Personalized and Precision Oncology Network (IPPON), Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium.
Lambrechts H; Center for Oncological Research (CORE), Integrated Personalized and Precision Oncology Network (IPPON), Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium.
Flieswasser T; Center for Oncological Research (CORE), Integrated Personalized and Precision Oncology Network (IPPON), Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium.
Quatannens D; Center for Oncological Research (CORE), Integrated Personalized and Precision Oncology Network (IPPON), Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium.
Roex G; Laboratory of Experimental Hematology (LEH), Vaccine and Infectious Disease Institute (VAXINFECTIO), Faculty of Medicine and Health Sciences, University of Antwerp, Edegem, Belgium.
Zwaenepoel K; Center for Oncological Research (CORE), Integrated Personalized and Precision Oncology Network (IPPON), Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium.; Department of Pathology, Antwerp University Hospital, Edegem, Belgium.
Marcq E; Center for Oncological Research (CORE), Integrated Personalized and Precision Oncology Network (IPPON), Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium.; Lab of Dendritic Cell Biology and Cancer Immunotherapy, VIB Center for Inflammation Research, Brussels, Belgium.; Brussels Center for Immunology, Vrije Universiteit Brussel, Brussels, Belgium.
Joye P; Molecular Imaging Center Antwerp (MICA), University of Antwerp, Wilrijk, Belgium.
Cardenas De La Hoz E; Industrial Vision Lab (InViLab), University of Antwerp, Antwerp, Belgium.
Deben C; Center for Oncological Research (CORE), Integrated Personalized and Precision Oncology Network (IPPON), Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium.
Gasparini A; Center for Oncological Research (CORE), Integrated Personalized and Precision Oncology Network (IPPON), Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium.; Iridium Netwerk, Radiation Oncology, Antwerp, Belgium.
Montay-Gruel P; Center for Oncological Research (CORE), Integrated Personalized and Precision Oncology Network (IPPON), Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium.; Iridium Netwerk, Radiation Oncology, Antwerp, Belgium.
Le Compte M; Center for Oncological Research (CORE), Integrated Personalized and Precision Oncology Network (IPPON), Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium.
Lion E; Laboratory of Experimental Hematology (LEH), Vaccine and Infectious Disease Institute (VAXINFECTIO), Faculty of Medicine and Health Sciences, University of Antwerp, Edegem, Belgium.; Center for Cell Therapy and Regenerative Medicine (CCRG), Antwerp University Hospital, Edegem, Belgium.
Lardon F; Center for Oncological Research (CORE), Integrated Personalized and Precision Oncology Network (IPPON), Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium.
Van Laere S; Center for Oncological Research (CORE), Integrated Personalized and Precision Oncology Network (IPPON), Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium.; Department of Pathology, Antwerp University Hospital, Edegem, Belgium.
Siozopoulou V; Center for Oncological Research (CORE), Integrated Personalized and Precision Oncology Network (IPPON), Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium.; University Hospital Saint-Luc, University of Louvain, Brussels, Belgium.
Campillo-Davo D; Laboratory of Experimental Hematology (LEH), Vaccine and Infectious Disease Institute (VAXINFECTIO), Faculty of Medicine and Health Sciences, University of Antwerp, Edegem, Belgium.
De Waele J; Center for Oncological Research (CORE), Integrated Personalized and Precision Oncology Network (IPPON), Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium.
Pauwels P; Center for Oncological Research (CORE), Integrated Personalized and Precision Oncology Network (IPPON), Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium.; Department of Pathology, Antwerp University Hospital, Edegem, Belgium.
Jacobs J; Center for Oncological Research (CORE), Integrated Personalized and Precision Oncology Network (IPPON), Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium.
Smits E; Center for Oncological Research (CORE), Integrated Personalized and Precision Oncology Network (IPPON), Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium.
Van Audenaerde JRM; Center for Oncological Research (CORE), Integrated Personalized and Precision Oncology Network (IPPON), Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium.; Pokaż więcej
Źródło:: Journal of hematology & oncology [J Hematol Oncol] 2024 Feb 09; Vol. 17 (1), pp. 8. Date of Electronic Publication: 2024 Feb 09.
Typ publikacji:: Journal Article
MeSH Terms:: Cancer-Associated Fibroblasts*
Lymphoma*/metabolism
Humans ; Animals ; Mice ; Cytotoxicity, Immunologic ; Interleukin-15/metabolism ; Cell Line, Tumor ; Killer Cells, Natural ; Immunotherapy, Adoptive/methods ; Cytokines/metabolism ; CD27 Ligand

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Skocz do pozycji: 16.

Tytuł:: ZFP36 disruption is insufficient to enhance the function of mesothelin-targeting human CAR-T cells.
Autorzy:: Mai D; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA. .; Center for Cellular Immunotherapies, Perelman School of Medicine, Philadelphia, PA, USA. .
Boyce T; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.
Mehta A; Department of Biology, University of Pennsylvania, Philadelphia, PA, USA.; The Wharton School, University of Pennsylvania, Philadelphia, PA, USA.
Reff J; Center for Cellular Immunotherapies, Perelman School of Medicine, Philadelphia, PA, USA.
Scholler J; Center for Cellular Immunotherapies, Perelman School of Medicine, Philadelphia, PA, USA.
Sheppard NC; Center for Cellular Immunotherapies, Perelman School of Medicine, Philadelphia, PA, USA.; Department of Pathology and Lab Medicine, Perelman School of Medicine, Philadelphia, PA, USA.
June CH; Center for Cellular Immunotherapies, Perelman School of Medicine, Philadelphia, PA, USA.; Department of Pathology and Lab Medicine, Perelman School of Medicine, Philadelphia, PA, USA.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2024 Feb 07; Vol. 14 (1), pp. 3113. Date of Electronic Publication: 2024 Feb 07.
Typ publikacji:: Journal Article
MeSH Terms:: Mesothelin*
Immunotherapy, Adoptive*/methods
Humans ; Animals ; Mice ; T-Lymphocytes/metabolism ; Immunity ; Cytokines/metabolism ; Disease Models, Animal ; Xenograft Model Antitumor Assays ; Cell Line, Tumor ; Tristetraprolin/genetics

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Skocz do pozycji: 17.

Tytuł:: Efficacy and side effects of anti-CD19 CAR T-cell therapy in patients with relapsed/refractory gastrointestinal lymphoma.
Autorzy:: Jiang YL; Department of Hematology, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, China.
Mu J; Department of Hematology, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, China.
Cui R; Department of Hematology, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, China.
Li X; Department of Hematology, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, China.
Wang J; Department of Hematology, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, China.
Li Q; Department of Hematology, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, China.
Li J; Department of Hematology, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, China.
Mou N; Shanghai Genbase Biotechnology Co., Ltd, Shanghai, China.
Deng Q; Department of Hematology, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, China.; Pokaż więcej
Źródło:: Cancer medicine [Cancer Med] 2024 Feb; Vol. 13 (4), pp. e7064.
Typ publikacji:: Journal Article
MeSH Terms:: Lymphoma*/therapy
Lymphoma, B-Cell*/etiology
Gastrointestinal Neoplasms*/therapy
Gastrointestinal Neoplasms*/etiology
Humans ; Immunotherapy, Adoptive/adverse effects ; Receptors, Antigen, T-Cell ; T-Lymphocytes ; Ulcer/etiology ; Cytokine Release Syndrome/etiology ; Antigens, CD19 ; Gastrointestinal Hemorrhage

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Skocz do pozycji: 18.

Tytuł:: In Vitro Functionality and Endurance of GMP-Compliant Point-of-Care BCMA.CAR-T Cells at Different Timepoints of Cryopreservation.
Autorzy:: Jiang G; Department of Internal Medicine V, University Clinic Heidelberg, 69120 Heidelberg, Germany.
Neuber B; Department of Internal Medicine V, University Clinic Heidelberg, 69120 Heidelberg, Germany.
Hückelhoven-Krauss A; Department of Internal Medicine V, University Clinic Heidelberg, 69120 Heidelberg, Germany.
Höpken UE; Department of Translational Tumor Immunology, Max-Delbrück Center for Molecular Medicine (MDC), 13125 Berlin, Germany.
Ding Y; Department of Internal Medicine V, University Clinic Heidelberg, 69120 Heidelberg, Germany.
Sedloev D; Department of Internal Medicine V, University Clinic Heidelberg, 69120 Heidelberg, Germany.
Wang L; Department of Internal Medicine V, University Clinic Heidelberg, 69120 Heidelberg, Germany.
Reichman A; Department of Internal Medicine V, University Clinic Heidelberg, 69120 Heidelberg, Germany.
Eberhardt F; Department of Internal Medicine V, University Clinic Heidelberg, 69120 Heidelberg, Germany.
Wermke M; Early Clinical Trial Unit (ECTU), Medical Clinic and Poliklinik I, Carl Gustav Carus University, 01307 Dresden, Germany.
Rehm A; Department of Translational Tumor Immunology, Max-Delbrück Center for Molecular Medicine (MDC), 13125 Berlin, Germany.
Müller-Tidow C; Department of Internal Medicine V, University Clinic Heidelberg, 69120 Heidelberg, Germany.
Schmitt A; Department of Internal Medicine V, University Clinic Heidelberg, 69120 Heidelberg, Germany.
Schmitt M; Department of Internal Medicine V, University Clinic Heidelberg, 69120 Heidelberg, Germany.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Jan 23; Vol. 25 (3). Date of Electronic Publication: 2024 Jan 23.
Typ publikacji:: Journal Article
MeSH Terms:: Receptors, Chimeric Antigen*
Multiple Myeloma*/pathology
Humans ; B-Cell Maturation Antigen/metabolism ; Point-of-Care Systems ; Immunotherapy, Adoptive/methods ; Cytokines/metabolism ; T-Lymphocytes ; Cryopreservation

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Skocz do pozycji: 19.

Tytuł:: Co-expression of IL-21-Enhanced NKG2D CAR-NK cell therapy for lung cancer.
Autorzy:: Zhang Y; Department of Oncology, Shenyang 242 Hospital, 110034, Shenyang, China.
Zhang C; Department of Oncology, Hospital of Chengdu University of Traditional Chinese Medicine, 610072, Chengdu, China.
He M; Department of Respiratory and Critical Care Medicine, Yidu Central Hospital of Weifang, 262500, Weifang, China.
Xing W; Geneis Beijing Co., Ltd., 100102, Beijing, China.
Hou R; Geneis Beijing Co., Ltd., 100102, Beijing, China. .
Zhang H; Department of Respiratory and Critical Care Medicine, Yidu Central Hospital of Weifang, 262500, Weifang, China. .; Pokaż więcej
Źródło:: BMC cancer [BMC Cancer] 2024 Jan 23; Vol. 24 (1), pp. 119. Date of Electronic Publication: 2024 Jan 23.
Typ publikacji:: Journal Article
MeSH Terms:: NK Cell Lectin-Like Receptor Subfamily K*
Lung Neoplasms*
Interleukins*
Humans ; Immunotherapy, Adoptive ; Cell- and Tissue-Based Therapy

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Skocz do pozycji: 20.

Tytuł:: Role of Immunotherapy in Sarcomas.
Autorzy:: Dalal S; Memorial Healthcare, Division of Hematology and Oncology, Pembroke Pines, FL 33028, USA.
Shan KS; Memorial Healthcare, Division of Hematology and Oncology, Pembroke Pines, FL 33028, USA.
Thaw Dar NN; Memorial Healthcare, Division of Hematology and Oncology, Pembroke Pines, FL 33028, USA.
Hussein A; Memorial Healthcare, Division of Hematology and Oncology, Pembroke Pines, FL 33028, USA.
Ergle A; Memorial Healthcare, Division of Hematology and Oncology, Pembroke Pines, FL 33028, USA.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Jan 19; Vol. 25 (2). Date of Electronic Publication: 2024 Jan 19.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Sarcoma*/drug therapy
Soft Tissue Neoplasms*
Hematologic Neoplasms*
Humans ; Immunotherapy ; Immunotherapy, Adoptive ; Tumor Microenvironment

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