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Tytuł :
PARP Inhibitors in Prostate Cancer.
Autorzy :
Grewal K; Florida State University College of Medicine, Tallahassee, FL, U.S.A.
Grewal K; George Mason University, Fairfax, VA, U.S.A.
Tabbara IA; George Washington University School of Medicine, Washington, DC, U.S.A. .
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Źródło :
Anticancer research [Anticancer Res] 2021 Feb; Vol. 41 (2), pp. 551-556.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Indazoles/*therapeutic use
Indoles/*therapeutic use
Phthalazines/*therapeutic use
Piperazines/*therapeutic use
Piperidines/*therapeutic use
Poly(ADP-ribose) Polymerase Inhibitors/*therapeutic use
Prostatic Neoplasms/*drug therapy
Animals ; BRCA1 Protein/genetics ; BRCA2 Protein/genetics ; Genetic Predisposition to Disease ; Humans ; Indazoles/adverse effects ; Indoles/adverse effects ; Male ; Mutation ; Neoplasm Metastasis ; PTEN Phosphohydrolase/genetics ; Phenotype ; Phthalazines/adverse effects ; Piperazines/adverse effects ; Piperidines/adverse effects ; Poly(ADP-ribose) Polymerase Inhibitors/adverse effects ; Prostatic Neoplasms/enzymology ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/pathology ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Selective Inhibitors of G2019S-LRRK2 Kinase Activity.
Autorzy :
Garofalo AW; ESCAPE Bio, South San Francisco, California 94080, United States.
Bright J; ESCAPE Bio, South San Francisco, California 94080, United States.
De Lombaert S; ESCAPE Bio, South San Francisco, California 94080, United States.
Toda AMA; ESCAPE Bio, South San Francisco, California 94080, United States.
Zobel K; ESCAPE Bio, South San Francisco, California 94080, United States.
Andreotti D; Aptuit, an Evotec Company, Verona 37135, Italy.
Beato C; Aptuit, an Evotec Company, Verona 37135, Italy.
Bernardi S; Aptuit, an Evotec Company, Verona 37135, Italy.
Budassi F; Aptuit, an Evotec Company, Verona 37135, Italy.
Caberlotto L; Aptuit, an Evotec Company, Verona 37135, Italy.
Gao P; WuXi AppTec, Tianjin 300456, P. R. China.
Griffante C; Aptuit, an Evotec Company, Verona 37135, Italy.
Liu X; WuXi AppTec, Tianjin 300456, P. R. China.
Mengatto L; Aptuit, an Evotec Company, Verona 37135, Italy.
Migliore M; Aptuit, an Evotec Company, Verona 37135, Italy.
Sabbatini FM; Aptuit, an Evotec Company, Verona 37135, Italy.
Sava A; Aptuit, an Evotec Company, Verona 37135, Italy.
Serra E; Aptuit, an Evotec Company, Verona 37135, Italy.
Vincetti P; Aptuit, an Evotec Company, Verona 37135, Italy.
Zhang M; WuXi AppTec, Tianjin 300456, P. R. China.
Carlisle HJ; ESCAPE Bio, South San Francisco, California 94080, United States.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Dec 10; Vol. 63 (23), pp. 14821-14839. Date of Electronic Publication: 2020 Nov 16.
Typ publikacji :
Journal Article
MeSH Terms :
Indazoles/*pharmacology
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/*antagonists & inhibitors
Protein Kinase Inhibitors/*pharmacology
Pyrimidines/*pharmacology
Tetrazoles/*pharmacology
Animals ; HEK293 Cells ; High-Throughput Screening Assays ; Humans ; Indazoles/chemical synthesis ; Indazoles/pharmacokinetics ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/genetics ; Mice ; Molecular Structure ; Mutation ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/pharmacokinetics ; Pyrimidines/chemical synthesis ; Pyrimidines/pharmacokinetics ; Small Molecule Libraries/chemical synthesis ; Small Molecule Libraries/pharmacokinetics ; Small Molecule Libraries/pharmacology ; Structure-Activity Relationship ; Tetrazoles/chemical synthesis ; Tetrazoles/pharmacokinetics
Czasopismo naukowe
Tytuł :
Cost-effectiveness of Maintenance Therapy Based on Molecular Classification Following Treatment of Primary Epithelial Ovarian Cancer in the United States.
Autorzy :
Penn CA; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, California.
Wong MS; Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, California.
Walsh CS; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, California.
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Źródło :
JAMA network open [JAMA Netw Open] 2020 Dec 01; Vol. 3 (12), pp. e2028620. Date of Electronic Publication: 2020 Dec 01.
Typ publikacji :
Journal Article
MeSH Terms :
Bevacizumab*/economics
Bevacizumab*/therapeutic use
Carcinoma, Ovarian Epithelial*/drug therapy
Carcinoma, Ovarian Epithelial*/economics
Carcinoma, Ovarian Epithelial*/genetics
Carcinoma, Ovarian Epithelial*/pathology
Indazoles*/economics
Indazoles*/therapeutic use
Maintenance Chemotherapy*/economics
Maintenance Chemotherapy*/methods
Ovarian Neoplasms*/drug therapy
Ovarian Neoplasms*/economics
Ovarian Neoplasms*/genetics
Ovarian Neoplasms*/pathology
Phthalazines*/economics
Phthalazines*/therapeutic use
Piperazines*/economics
Piperazines*/therapeutic use
Piperidines*/economics
Piperidines*/therapeutic use
Antineoplastic Agents, Immunological/economics ; Antineoplastic Agents, Immunological/therapeutic use ; Computing Methodologies ; Cost-Benefit Analysis ; Female ; Genes, BRCA1 ; Genes, BRCA2 ; Homologous Recombination ; Humans ; Medicare/statistics & numerical data ; Neoplasm Staging ; United States
Czasopismo naukowe
Tytuł :
Design, synthesis and biological evaluation of novel 1 H -1,2,4-triazole, benzothiazole and indazole-based derivatives as potent FGFR1 inhibitors via fragment-based virtual screening.
Autorzy :
Liu J; Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Stake Key Laboratory Cultivation Base for TCM Quality and Efficacy, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, PR China.
Wen Y; Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Stake Key Laboratory Cultivation Base for TCM Quality and Efficacy, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, PR China.
Gao L; Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Stake Key Laboratory Cultivation Base for TCM Quality and Efficacy, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, PR China.
Gao L; Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Stake Key Laboratory Cultivation Base for TCM Quality and Efficacy, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, PR China.
He F; Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Stake Key Laboratory Cultivation Base for TCM Quality and Efficacy, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, PR China.
Zhou J; Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Stake Key Laboratory Cultivation Base for TCM Quality and Efficacy, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, PR China.
Wang J; Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Stake Key Laboratory Cultivation Base for TCM Quality and Efficacy, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, PR China.
Dai R; Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Stake Key Laboratory Cultivation Base for TCM Quality and Efficacy, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, PR China.
Chen X; Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Stake Key Laboratory Cultivation Base for TCM Quality and Efficacy, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, PR China.
Kang D; Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Stake Key Laboratory Cultivation Base for TCM Quality and Efficacy, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, PR China.
Hu L; Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Stake Key Laboratory Cultivation Base for TCM Quality and Efficacy, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, PR China.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 72-84.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Antineoplastic Agents/*pharmacology
Benzothiazoles/*pharmacology
Indazoles/*pharmacology
Protein Kinase Inhibitors/*pharmacology
Receptor, Fibroblast Growth Factor, Type 1/*antagonists & inhibitors
Triazoles/*pharmacology
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Benzothiazoles/chemical synthesis ; Benzothiazoles/chemistry ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Indazoles/chemical synthesis ; Indazoles/chemistry ; Molecular Docking Simulation ; Molecular Structure ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Receptor, Fibroblast Growth Factor, Type 1/metabolism ; Structure-Activity Relationship ; Triazoles/chemical synthesis ; Triazoles/chemistry
Czasopismo naukowe
Tytuł :
Lorecivivint, an intra-articular potential disease-modifying osteoarthritis drug.
Autorzy :
Sabha M; Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Maryland School of Medicine , Baltimore, MD, USA.
Siaton BC; Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Maryland School of Medicine , Baltimore, MD, USA.
Hochberg MC; Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Maryland School of Medicine , Baltimore, MD, USA.; Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine , Baltimore, USA.
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Źródło :
Expert opinion on investigational drugs [Expert Opin Investig Drugs] 2020 Dec; Vol. 29 (12), pp. 1339-1346. Date of Electronic Publication: 2020 Nov 08.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antirheumatic Agents/*administration & dosage
Imidazoles/*administration & dosage
Indazoles/*administration & dosage
Osteoarthritis, Knee/*drug therapy
Pyridines/*administration & dosage
Animals ; Anti-Inflammatory Agents/administration & dosage ; Anti-Inflammatory Agents/adverse effects ; Anti-Inflammatory Agents/pharmacology ; Antirheumatic Agents/adverse effects ; Antirheumatic Agents/pharmacology ; Humans ; Imidazoles/adverse effects ; Imidazoles/pharmacology ; Indazoles/adverse effects ; Indazoles/pharmacology ; Osteoarthritis, Knee/pathology ; Pyridines/adverse effects ; Pyridines/pharmacology ; Quality of Life
Czasopismo naukowe
Tytuł :
Evaluating entrectinib as a treatment option for non-small cell lung cancer.
Autorzy :
Lee J; Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul, Korea.
Park S; Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul, Korea.
Jung HA; Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul, Korea.
Sun JM; Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul, Korea.
Lee SH; Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul, Korea.
Ahn JS; Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul, Korea.
Park K; Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul, Korea.
Ahn MJ; Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul, Korea.
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Źródło :
Expert opinion on pharmacotherapy [Expert Opin Pharmacother] 2020 Nov; Vol. 21 (16), pp. 1935-1942. Date of Electronic Publication: 2020 Jul 31.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Benzamides/*therapeutic use
Carcinoma, Non-Small-Cell Lung/*drug therapy
Indazoles/*therapeutic use
Lung Neoplasms/*drug therapy
Protein Kinase Inhibitors/*therapeutic use
Protein-Tyrosine Kinases/*metabolism
Administration, Oral ; Benzamides/administration & dosage ; Benzamides/adverse effects ; Carcinoma, Non-Small-Cell Lung/enzymology ; Carcinoma, Non-Small-Cell Lung/pathology ; Clinical Trials as Topic ; Humans ; Indazoles/administration & dosage ; Indazoles/adverse effects ; Lung Neoplasms/enzymology ; Lung Neoplasms/pathology ; Protein Kinase Inhibitors/administration & dosage ; Protein Kinase Inhibitors/adverse effects ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Nephrotoxicity Associated With Niraparib.
Autorzy :
Lazareth H; Service de Néphrologie, Hôpital Européen Georges Pompidou, APHP, Université Paris Descartes, Sorbonne Paris Cité, France. Electronic address: .
Delanoy N; Service d'Oncologie Médicale, Hôpital Européen Georges Pompidou, APHP, Université Paris Descartes, Sorbonne Paris Cité, France.
Cohen R; Service de Physiologie et explorations fonctionnelles, Hôpital Européen Georges Pompidou, APHP, Université Paris Descartes, Sorbonne Paris Cité, France.
Boissier E; Service d'Oncologie Médicale, Hôpital Européen Georges Pompidou, APHP, Université Paris Descartes, Sorbonne Paris Cité, France.
Ayari H; Service de Physiologie et explorations fonctionnelles, Hôpital Européen Georges Pompidou, APHP, Université Paris Descartes, Sorbonne Paris Cité, France.
Combe P; Service d'Oncologie Médicale, Hôpital Européen Georges Pompidou, APHP, Université Paris Descartes, Sorbonne Paris Cité, France.
Crespel C; Service d'Oncologie Médicale, Hôpital Européen Georges Pompidou, APHP, Université Paris Descartes, Sorbonne Paris Cité, France.
Mercadier-Riaz E; Service de Gériatrie, Hôpital Européen Georges Pompidou, APHP, Université Paris Descartes, Sorbonne Paris Cité, France.
Karras A; Service de Néphrologie, Hôpital Européen Georges Pompidou, APHP, Université Paris Descartes, Sorbonne Paris Cité, France.
Courbebaisse M; Service de Physiologie et explorations fonctionnelles, Hôpital Européen Georges Pompidou, APHP, Université Paris Descartes, Sorbonne Paris Cité, France.
Thervet E; Service de Néphrologie, Hôpital Européen Georges Pompidou, APHP, Université Paris Descartes, Sorbonne Paris Cité, France.
Pallet N; Service de Néphrologie, Hôpital Européen Georges Pompidou, APHP, Université Paris Descartes, Sorbonne Paris Cité, France; Service de Biochimie, Hôpital Européen Georges Pompidou, APHP, Université Paris Descartes, Sorbonne Paris Cité, France.
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Źródło :
American journal of kidney diseases : the official journal of the National Kidney Foundation [Am J Kidney Dis] 2020 Dec; Vol. 76 (6), pp. 898-900. Date of Electronic Publication: 2020 Jul 14.
Typ publikacji :
Letter
MeSH Terms :
Indazoles/*adverse effects
Kidney Diseases/*chemically induced
Ovarian Neoplasms/*drug therapy
Piperidines/*adverse effects
Aged ; Aged, 80 and over ; Dose-Response Relationship, Drug ; Female ; Humans ; Indazoles/administration & dosage ; Middle Aged ; Piperidines/administration & dosage ; Poly(ADP-ribose) Polymerase Inhibitors/administration & dosage ; Poly(ADP-ribose) Polymerase Inhibitors/adverse effects ; Risk Factors
Opinia redakcyjna
Tytuł :
Long-term safety in patients with recurrent ovarian cancer treated with niraparib versus placebo: Results from the phase III ENGOT-OV16/NOVA trial.
Autorzy :
Mirza MR; Nordic Society of Gynaecological Oncology Clinical Trial Unit (NSGO-CTU), Rigshospitalet-Copenhagen University Hospital, Copenhagen, Denmark. Electronic address: .
Benigno B; Northside Hospital, Atlanta, GA, USA.
Dørum A; Radiumhospitalet, Oslo University Hospital, NSGO, Oslo, Norway.
Mahner S; Department of Obstetrics and Gynecology, University Hospital, LMU Munich, AGO, Munich, Germany.
Bessette P; Sherbrooke University, Sherbrooke, QC, Canada.
Barceló IB; Hospital Son Llàtzer, GEICO, Palma de Mallorca, Spain.
Berton-Rigaud D; Institut de Cancérologie de l'Ouest Centre René Gauducheau, GINECO, Saint-Herblain, France.
Ledermann JA; UCL Cancer Institute, University College London, NCRI, London, UK.
Rimel BJ; Cedars-Sinai Medical Center, West Hollywood, CA, USA.
Herrstedt J; Odense University Hospital, Odense, Denmark; Zealand University Hospital, NSGO, Roskilde, Denmark.
Lau S; McGill University, Montreal, QC, Canada.
du Bois A; Kliniken Essen Mitte, AGO, Essen, Germany.
Herráez AC; Hospital Clínico San Carlos, GEICO, Madrid, Spain.
Kalbacher E; Centre Hospitalier Régional et Universitaire de Besançon, GINECO, Besançon, France.
Buscema J; Arizona Oncology Associates, Tucson, AZ, USA.
Lorusso D; Fondazione Policlinico Universitario a Gemelli IRCCS, Istituto Nazionale dei Tumori, MITO, Milan, Italy.
Vergote I; University of Leuven, Leuven Cancer Institute, BGOG, Leuven, Belgium.
Levy T; Wolfson Medical Center, ISGO, Holon, Israel.
Wang P; GlaxoSmithKline, Waltham, MA, USA.
de Jong FA; GlaxoSmithKline, Zug, Switzerland.
Gupta D; GlaxoSmithKline, Waltham, MA, USA.
Matulonis UA; Dana-Farber Cancer Institute, Boston, MA, USA.
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Źródło :
Gynecologic oncology [Gynecol Oncol] 2020 Nov; Vol. 159 (2), pp. 442-448. Date of Electronic Publication: 2020 Sep 25.
Typ publikacji :
Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinoma, Ovarian Epithelial/*drug therapy
Indazoles/*administration & dosage
Neoplasm Recurrence, Local/*drug therapy
Ovarian Neoplasms/*drug therapy
Piperidines/*administration & dosage
Poly(ADP-ribose) Polymerase Inhibitors/*administration & dosage
Double-Blind Method ; Female ; Humans ; Indazoles/adverse effects ; Maintenance Chemotherapy/methods ; Middle Aged ; Piperidines/adverse effects ; Poly(ADP-ribose) Polymerase Inhibitors/adverse effects ; Progression-Free Survival
Czasopismo naukowe
Tytuł :
[Drug approval : entrectinib and larotrectinib - cancers with NTRK fusion].
Autorzy :
Delaye M; Hôpital Tenon, service d'oncologie médicale et de thérapie cellulaire, 4, rue de la Chine, 75020 Paris, France; Association pour l'enseignement et la recherche des internes en oncologie (AERIO), 149, avenue du Maine, 75014 Paris, France.
Rodrigues M; PSL Research University, institut Curie, département d'oncologie médicale, 26, rue d'Ulm, 75005 Paris, France; PSL Research University, institut Curie, Inserm U830, 26, rue d'Ulm, 75005 Paris, France. Electronic address: .
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Transliterated Title :
AMM : entrectinib et larotrectinib – cancers avec fusion NTRK.
Źródło :
Bulletin du cancer [Bull Cancer] 2020 Nov; Vol. 107 (11), pp. 1085-1086. Date of Electronic Publication: 2020 Oct 21.
Typ publikacji :
Letter; News
MeSH Terms :
Drug Approval*
Oncogene Proteins, Fusion*
Benzamides/*therapeutic use
Indazoles/*therapeutic use
Neoplasms/*drug therapy
Protein Kinase Inhibitors/*therapeutic use
Pyrazoles/*therapeutic use
Pyrimidines/*therapeutic use
Adult ; Benzamides/adverse effects ; Child ; France ; Humans ; Indazoles/adverse effects ; Membrane Glycoproteins/genetics ; Neoplasms/genetics ; Neoplasms/mortality ; Protein Kinase Inhibitors/adverse effects ; Pyrazoles/adverse effects ; Pyrimidines/adverse effects ; Receptor, trkA/genetics ; Receptor, trkB/genetics ; Receptor, trkC/genetics
Periodyk
Tytuł :
Discovery of novel indazole-acylsulfonamide hybrids as selective Mcl-1 inhibitors.
Autorzy :
Wan Y; Key Laboratory of Theoretical Organic Chemistry and Functional Molecule, Ministry of Education, Hunan University of Science and Technology, Xiangtan, Hunan 411201, PR China; Hunan Provincial Key Laboratory of Controllable Preparation and Functional Application of Fine Polymers, Hunan Provincial Key Lab of Advanced Materials for New Energy Storage and Conversion, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, Hunan 411201, PR China. Electronic address: .
Li Y; Key Laboratory of Theoretical Organic Chemistry and Functional Molecule, Ministry of Education, Hunan University of Science and Technology, Xiangtan, Hunan 411201, PR China; Hunan Provincial Key Laboratory of Controllable Preparation and Functional Application of Fine Polymers, Hunan Provincial Key Lab of Advanced Materials for New Energy Storage and Conversion, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, Hunan 411201, PR China.
Yan C; Key Laboratory of Theoretical Organic Chemistry and Functional Molecule, Ministry of Education, Hunan University of Science and Technology, Xiangtan, Hunan 411201, PR China; Hunan Provincial Key Laboratory of Controllable Preparation and Functional Application of Fine Polymers, Hunan Provincial Key Lab of Advanced Materials for New Energy Storage and Conversion, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, Hunan 411201, PR China.
Wen J; Key Laboratory of Theoretical Organic Chemistry and Functional Molecule, Ministry of Education, Hunan University of Science and Technology, Xiangtan, Hunan 411201, PR China; Hunan Provincial Key Laboratory of Controllable Preparation and Functional Application of Fine Polymers, Hunan Provincial Key Lab of Advanced Materials for New Energy Storage and Conversion, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, Hunan 411201, PR China.
Tang Z; Key Laboratory of Theoretical Organic Chemistry and Functional Molecule, Ministry of Education, Hunan University of Science and Technology, Xiangtan, Hunan 411201, PR China; Hunan Provincial Key Laboratory of Controllable Preparation and Functional Application of Fine Polymers, Hunan Provincial Key Lab of Advanced Materials for New Energy Storage and Conversion, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, Hunan 411201, PR China.
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Źródło :
Bioorganic chemistry [Bioorg Chem] 2020 Nov; Vol. 104, pp. 104217. Date of Electronic Publication: 2020 Aug 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Discovery*
Antineoplastic Agents/*pharmacology
Indazoles/*pharmacology
Myeloid Cell Leukemia Sequence 1 Protein/*antagonists & inhibitors
Sulfonamides/*pharmacology
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; Cell Proliferation/drug effects ; Cells, Cultured ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Indazoles/chemistry ; Molecular Docking Simulation ; Molecular Structure ; Myeloid Cell Leukemia Sequence 1 Protein/metabolism ; Structure-Activity Relationship ; Sulfonamides/chemistry
Czasopismo naukowe
Tytuł :
Assessment of synthetic cannabinoid FUB-AMB and its ester hydrolysis metabolite in human liver microsomes and human blood samples using UHPLC-MS/MS.
Autorzy :
Presley BC; Department of Chemistry, Temple University, Philadelphia, Pennsylvania, USA.
Castaneto MS; Department of Pathology, Tripler Army Medical Center, Honolulu, Hawaii, USA.
Logan BK; The Center for Forensic Science Research and Education at the Fredric Rieders Family Foundation, Willow Grove, Pennsylvania, USA.
Jansen-Varnum SA; Department of Chemistry, Temple University, Philadelphia, Pennsylvania, USA.
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Źródło :
Biomedical chromatography : BMC [Biomed Chromatogr] 2020 Sep; Vol. 34 (9), pp. e4884. Date of Electronic Publication: 2020 Jul 07.
Typ publikacji :
Journal Article
MeSH Terms :
Chromatography, High Pressure Liquid/*methods
Indazoles/*blood
Indazoles/*metabolism
Microsomes, Liver/*metabolism
Tandem Mass Spectrometry/*methods
Valine/*analogs & derivatives
Adult ; Esters/metabolism ; Forensic Toxicology ; Humans ; Hydrolysis ; Indazoles/analysis ; Indazoles/chemistry ; Male ; Middle Aged ; Valine/analysis ; Valine/blood ; Valine/chemistry ; Valine/metabolism ; Young Adult
Czasopismo naukowe
Tytuł :
Significance of Competing Metabolic Pathways for 5F-APINACA Based on Quantitative Kinetics.
Autorzy :
Pinson AO; Department of Chemistry and Biochemistry, Harding University, Searcy, AR 72149, USA.
Pouncey DL; College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Schleiff MA; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Fantegrossi WE; Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Prather PL; Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Radominska-Pandya A; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Boysen G; Department of Environmental and Occupational Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Miller GP; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2020 Oct 20; Vol. 25 (20). Date of Electronic Publication: 2020 Oct 20.
Typ publikacji :
Journal Article
MeSH Terms :
Adamantane/*analogs & derivatives
Cannabinoids/*chemistry
Indazoles/*chemistry
Metabolic Networks and Pathways/*drug effects
Adamantane/chemical synthesis ; Adamantane/chemistry ; Adamantane/pharmacology ; Cannabinoids/chemical synthesis ; Humans ; Indazoles/chemical synthesis ; Indazoles/pharmacology ; Kinetics ; Microsomes, Liver/drug effects
Czasopismo naukowe
Tytuł :
Niraparib for the Treatment of Recurrent Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer.
Autorzy :
Kerliu L; Sanofi-Genzyme, Cambridge, MA, USA.
Myruski S; Sanofi-Genzyme, Cambridge, MA, USA.
Bhatti A; Sanofi-Genzyme, Cambridge, MA, USA.
Soni P; Sanofi-Genzyme, Cambridge, MA, USA.
Petrosius P; Sanofi-Genzyme, Cambridge, MA, USA.
Pervanas HC; MCPHS University Worcester/Manchester, Worcester, MA, USA.
Horton ER; MCPHS University Worcester/Manchester, Worcester, MA, USA.
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Źródło :
The Annals of pharmacotherapy [Ann Pharmacother] 2020 Oct; Vol. 54 (10), pp. 1010-1015. Date of Electronic Publication: 2020 Mar 16.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Carcinoma, Ovarian Epithelial/*drug therapy
Fallopian Tube Neoplasms/*drug therapy
Indazoles/*therapeutic use
Neoplasm Recurrence, Local/*drug therapy
Ovarian Neoplasms/*drug therapy
Peritoneal Neoplasms/*drug therapy
Piperidines/*therapeutic use
Poly(ADP-ribose) Polymerase Inhibitors/*therapeutic use
Carcinoma, Ovarian Epithelial/pathology ; Clinical Trials, Phase III as Topic ; Fallopian Tube Neoplasms/pathology ; Female ; Humans ; Indazoles/administration & dosage ; Indazoles/adverse effects ; Indazoles/pharmacokinetics ; Middle Aged ; Ovarian Neoplasms/pathology ; Peritoneal Neoplasms/pathology ; Piperidines/administration & dosage ; Piperidines/adverse effects ; Piperidines/pharmacokinetics ; Poly(ADP-ribose) Polymerase Inhibitors/administration & dosage ; Poly(ADP-ribose) Polymerase Inhibitors/adverse effects ; Poly(ADP-ribose) Polymerase Inhibitors/pharmacokinetics ; Progression-Free Survival
Czasopismo naukowe
Tytuł :
Activity profile of two 5-nitroindazole derivatives over the moderately drug-resistant Trypanosoma cruzi Y strain (DTU TcII): in vitro and in vivo studies.
Autorzy :
Fonseca-Berzal C; Departamento de Microbiología y Parasitología, Facultad de Farmacia, Universidad Complutense de Madrid (UCM), Pza. Ramón y Cajal s/n, 28040Madrid, Spain.
da Silva CF; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz (FIOCRUZ), Av. Brasil 4365, 21040-900Rio de Janeiro, Brazil.
Batista DDGJ; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz (FIOCRUZ), Av. Brasil 4365, 21040-900Rio de Janeiro, Brazil.
de Oliveira GM; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz (FIOCRUZ), Av. Brasil 4365, 21040-900Rio de Janeiro, Brazil.
Cumella J; Instituto de Química Médica (IQM), Consejo Superior de Investigaciones Científicas (CSIC), c/ Juan de la Cierva 3, 28006Madrid, Spain.
Batista MM; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz (FIOCRUZ), Av. Brasil 4365, 21040-900Rio de Janeiro, Brazil.
Peres RB; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz (FIOCRUZ), Av. Brasil 4365, 21040-900Rio de Janeiro, Brazil.
Silva da Gama Nefertiti A; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz (FIOCRUZ), Av. Brasil 4365, 21040-900Rio de Janeiro, Brazil.
Escario JA; Departamento de Microbiología y Parasitología, Facultad de Farmacia, Universidad Complutense de Madrid (UCM), Pza. Ramón y Cajal s/n, 28040Madrid, Spain.
Gómez-Barrio A; Departamento de Microbiología y Parasitología, Facultad de Farmacia, Universidad Complutense de Madrid (UCM), Pza. Ramón y Cajal s/n, 28040Madrid, Spain.
Arán VJ; Instituto de Química Médica (IQM), Consejo Superior de Investigaciones Científicas (CSIC), c/ Juan de la Cierva 3, 28006Madrid, Spain.
Soeiro MNC; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz (FIOCRUZ), Av. Brasil 4365, 21040-900Rio de Janeiro, Brazil.
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Źródło :
Parasitology [Parasitology] 2020 Sep; Vol. 147 (11), pp. 1216-1228. Date of Electronic Publication: 2020 Jun 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Indazoles*/pharmacology
Indazoles*/toxicity
Trypanosoma cruzi/*drug effects
Animals ; Cell Line ; Chagas Disease/drug therapy ; Chagas Disease/parasitology ; Drug Resistance ; Drug Therapy, Combination ; Humans ; Mice ; Nitroimidazoles/pharmacology ; Parasitemia/drug therapy ; Trypanocidal Agents/pharmacology ; Trypanocidal Agents/toxicity
Czasopismo naukowe
Tytuł :
New nitroindazole-porphyrin conjugates: Synthesis, characterization and antibacterial properties.
Autorzy :
Eddahmi M; LAQV-REQUIMTE, Chemistry Department, University of Aveiro, 3810-193 Aveiro, Portugal; Laboratory of Organic and Analytic Chemistry, Faculty of Sciences and Technics, Sultan Moulay Slimane University, BP 523, 2300 Beni-Mellal, Morocco.
Sousa V; CESAM and Biology Department, University of Aveiro, 3810-193 Aveiro, Portugal.
Moura NMM; LAQV-REQUIMTE, Chemistry Department, University of Aveiro, 3810-193 Aveiro, Portugal. Electronic address: .
Dias CJ; LAQV-REQUIMTE, Chemistry Department, University of Aveiro, 3810-193 Aveiro, Portugal.
Bouissane L; Laboratory of Organic and Analytic Chemistry, Faculty of Sciences and Technics, Sultan Moulay Slimane University, BP 523, 2300 Beni-Mellal, Morocco.
Faustino MAF; LAQV-REQUIMTE, Chemistry Department, University of Aveiro, 3810-193 Aveiro, Portugal. Electronic address: .
Cavaleiro JAS; LAQV-REQUIMTE, Chemistry Department, University of Aveiro, 3810-193 Aveiro, Portugal.
Gomes ATPC; Laboratory of Organic and Analytic Chemistry, Faculty of Sciences and Technics, Sultan Moulay Slimane University, BP 523, 2300 Beni-Mellal, Morocco. Electronic address: .
Almeida A; CESAM and Biology Department, University of Aveiro, 3810-193 Aveiro, Portugal.
Neves MGPMS; LAQV-REQUIMTE, Chemistry Department, University of Aveiro, 3810-193 Aveiro, Portugal.
Mostapha Rakib E; Laboratory of Organic and Analytic Chemistry, Faculty of Sciences and Technics, Sultan Moulay Slimane University, BP 523, 2300 Beni-Mellal, Morocco. Electronic address: .
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Źródło :
Bioorganic chemistry [Bioorg Chem] 2020 Aug; Vol. 101, pp. 103994. Date of Electronic Publication: 2020 Jun 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-Bacterial Agents/*chemistry
Anti-Bacterial Agents/*pharmacology
Indazoles/*chemistry
Indazoles/*pharmacology
Porphyrins/*chemistry
Porphyrins/*pharmacology
Anti-Bacterial Agents/chemical synthesis ; Indazoles/chemical synthesis ; Methicillin-Resistant Staphylococcus aureus/drug effects ; Microbial Sensitivity Tests ; Photochemotherapy ; Photosensitizing Agents/chemical synthesis ; Photosensitizing Agents/chemistry ; Photosensitizing Agents/pharmacology ; Porphyrins/chemical synthesis ; Singlet Oxygen/chemistry ; Spectrum Analysis/methods
Czasopismo naukowe
Tytuł :
Lorecivivint, a Novel Intraarticular CDC-like Kinase 2 and Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A Inhibitor and Wnt Pathway Modulator for the Treatment of Knee Osteoarthritis: A Phase II Randomized Trial.
Autorzy :
Yazici Y; Samumed LLC, San Diego, California.
McAlindon TE; Tufts Medical Center, Boston, Massachusetts.
Gibofsky A; Weill Cornell Medical College, New York, New York.
Lane NE; UC Davis Medical School, Burlingame, California.
Clauw D; University of Michigan, Ann Arbor.
Jones M; Cleveland Clinic, Cleveland, Ohio.
Bergfeld J; Cleveland Clinic, Cleveland, Ohio.
Swearingen CJ; Samumed, LLC, San Diego, California.
DiFrancesco A; Samumed, LLC, San Diego, California.
Simsek I; Samumed, LLC, San Diego, California.
Tambiah J; Samumed, LLC, San Diego, California.
Hochberg MC; University of Maryland School of Medicine, Baltimore, Maryland.
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Źródło :
Arthritis & rheumatology (Hoboken, N.J.) [Arthritis Rheumatol] 2020 Oct; Vol. 72 (10), pp. 1694-1706. Date of Electronic Publication: 2020 Sep 06.
Typ publikacji :
Clinical Trial, Phase II; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Imidazoles/*therapeutic use
Indazoles/*therapeutic use
Osteoarthritis, Knee/*drug therapy
Protein Kinase Inhibitors/*therapeutic use
Pyridines/*therapeutic use
Aged ; Dose-Response Relationship, Drug ; Double-Blind Method ; Female ; Humans ; Imidazoles/administration & dosage ; Indazoles/administration & dosage ; Injections, Intra-Articular ; Male ; Middle Aged ; Osteoarthritis, Knee/physiopathology ; Pain Measurement ; Protein Kinase Inhibitors/administration & dosage ; Protein-Serine-Threonine Kinases/antagonists & inhibitors ; Protein-Tyrosine Kinases/antagonists & inhibitors ; Pyridines/administration & dosage ; Treatment Outcome ; Wnt Signaling Pathway/drug effects
Czasopismo naukowe
Tytuł :
Integrating experimental and computational techniques to study chromatographic enantioresolutions of chiral tetrahydroindazole derivatives.
Autorzy :
Ianni F; Department of Pharmaceutical Sciences, University of Perugia, Via Fabretti 48, 06123 - Perugia, Italy.
Cerra B; Department of Pharmaceutical Sciences, University of Perugia, Via Fabretti 48, 06123 - Perugia, Italy.
Shandiz ST; Department of Pharmaceutical Sciences, University of Perugia, Via Fabretti 48, 06123 - Perugia, Italy.
Michele AD; Department of Physics and Geology, University of Perugia, Via Pascoli 1, 06123 - Perugia, Italy.
Saluti G; Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche 'Togo Rosati', Via G. Salvemini, 1, 06126 - Perugia, Italy.
Galarini R; Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche 'Togo Rosati', Via G. Salvemini, 1, 06126 - Perugia, Italy.
Gioiello A; Department of Pharmaceutical Sciences, University of Perugia, Via Fabretti 48, 06123 - Perugia, Italy.
Sardella R; Department of Pharmaceutical Sciences, University of Perugia, Via Fabretti 48, 06123 - Perugia, Italy. Electronic address: .
Carotti A; Department of Pharmaceutical Sciences, University of Perugia, Via Fabretti 48, 06123 - Perugia, Italy. Electronic address: .
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Źródło :
Journal of chromatography. A [J Chromatogr A] 2020 Aug 16; Vol. 1625, pp. 461310. Date of Electronic Publication: 2020 Jun 08.
Typ publikacji :
Journal Article
MeSH Terms :
Molecular Dynamics Simulation*
Chromatography, Liquid/*methods
Indazoles/*chemistry
Indazoles/chemical synthesis ; Solvents ; Stereoisomerism
Czasopismo naukowe
Tytuł :
Structure-Based Drug Discovery of N -(( R )-3-(7-Methyl-1 H -indazol-5-yl)-1-oxo-1-((( S )-1-oxo-3-(piperidin-4-yl)-1-(4-(pyridin-4-yl)piperazin-1-yl)propan-2-yl)amino)propan-2-yl)-2'-oxo-1',2'-dihydrospiro[piperidine-4,4'-pyrido[2,3- d ][1,3]oxazine]-1-carboxamide (HTL22562): A Calcitonin Gene-Related Peptide Receptor Antagonist for Acute Treatment of Migraine.
Autorzy :
Bucknell SJ; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, U.K.
Ator MA; Teva Pharmaceuticals, 145 Brandywine Parkway, West Chester, Pennsylvania 19380, United States.
Brown AJH; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, U.K.
Brown J; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, U.K.
Cansfield AD; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, U.K.
Cansfield JE; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, U.K.
Christopher JA; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, U.K.
Congreve M; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, U.K.
Cseke G; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, U.K.
Deflorian F; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, U.K.
Jones CR; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, U.K.
Mason JS; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, U.K.
O'Brien MA; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, U.K.
Ott GR; Teva Pharmaceuticals, 145 Brandywine Parkway, West Chester, Pennsylvania 19380, United States.
Pickworth M; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, U.K.
Southall SM; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, U.K.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Jul 23; Vol. 63 (14), pp. 7906-7920. Date of Electronic Publication: 2020 Jul 08.
Typ publikacji :
Journal Article
MeSH Terms :
Calcitonin Gene-Related Peptide Receptor Antagonists/*pharmacology
Indazoles/*pharmacology
Receptors, Calcitonin Gene-Related Peptide/*metabolism
Spiro Compounds/*pharmacology
Animals ; Binding Sites ; Calcitonin Gene-Related Peptide Receptor Antagonists/chemical synthesis ; Calcitonin Gene-Related Peptide Receptor Antagonists/metabolism ; Calcitonin Gene-Related Peptide Receptor Antagonists/toxicity ; Dogs ; Drug Design ; Humans ; Indazoles/chemical synthesis ; Indazoles/metabolism ; Indazoles/toxicity ; Macaca fascicularis ; Migraine Disorders/drug therapy ; Molecular Docking Simulation ; Molecular Structure ; Rats ; Spiro Compounds/chemical synthesis ; Spiro Compounds/metabolism ; Spiro Compounds/toxicity ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Biomimetic oral targeted delivery of bindarit for immunotherapy of atherosclerosis.
Autorzy :
Yin L; Department of Pharmaceutics, College of Pharmacy, Third Military Medical University, Chongqing 400038, China. .
Peng C
Tang Y
Yuan Y
Liu J
Xiang T
Liu F
Zhou X
Li X
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Źródło :
Biomaterials science [Biomater Sci] 2020 Jul 07; Vol. 8 (13), pp. 3640-3648. Date of Electronic Publication: 2020 May 27.
Typ publikacji :
Journal Article
MeSH Terms :
Biomimetics*
Drug Delivery Systems*
Immunotherapy*
Biocompatible Materials/*chemistry
Indazoles/*chemistry
Plaque, Atherosclerotic/*therapy
Propionates/*chemistry
Administration, Oral ; Animals ; Biocompatible Materials/administration & dosage ; Biocompatible Materials/pharmacology ; Carbocyanines/administration & dosage ; Carbocyanines/chemistry ; Cells, Cultured ; Chemokine CCL2/antagonists & inhibitors ; Dose-Response Relationship, Drug ; Indazoles/administration & dosage ; Indazoles/pharmacology ; Male ; Mice ; Mice, Knockout ; Plaque, Atherosclerotic/immunology ; Propionates/administration & dosage ; Propionates/pharmacology ; RAW 264.7 Cells
Czasopismo naukowe
Tytuł :
Entrectinib for the treatment of metastatic NSCLC: safety and efficacy.
Autorzy :
Sartore-Bianchi A; Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy.; Department of Oncology and Hemato-Oncology, Università Degli Studi Di Milano, Milan, Italy.
Pizzutilo EG; Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy.; Department of Oncology and Hemato-Oncology, Università Degli Studi Di Milano, Milan, Italy.
Marrapese G; Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Tosi F; Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy.; Department of Oncology and Hemato-Oncology, Università Degli Studi Di Milano, Milan, Italy.
Cerea G; Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Siena S; Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy.; Department of Oncology and Hemato-Oncology, Università Degli Studi Di Milano, Milan, Italy.
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Źródło :
Expert review of anticancer therapy [Expert Rev Anticancer Ther] 2020 May; Vol. 20 (5), pp. 333-341. Date of Electronic Publication: 2020 Apr 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Benzamides/*administration & dosage
Carcinoma, Non-Small-Cell Lung/*drug therapy
Indazoles/*administration & dosage
Lung Neoplasms/*drug therapy
Animals ; Benzamides/adverse effects ; Benzamides/pharmacology ; Carcinoma, Non-Small-Cell Lung/genetics ; Disease Progression ; Gene Fusion ; Gene Rearrangement ; Humans ; Indazoles/adverse effects ; Indazoles/pharmacology ; Lung Neoplasms/genetics ; Protein Kinase Inhibitors/administration & dosage ; Protein Kinase Inhibitors/adverse effects ; Protein Kinase Inhibitors/pharmacology ; Protein-Tyrosine Kinases/genetics ; Proto-Oncogene Proteins/genetics
Czasopismo naukowe

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