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Wyświetlanie 1-20 z 203
Tytuł:
Tetrazo[1,2‐b]indazoles: Straightforward Access to Nitrogen‐Rich Polyaromatics from s‐Tetrazines.
Autorzy:
Daher, Ahmad (AUTHOR)
Bousfiha, Asmae (AUTHOR)
Tolbatov, Iogann (AUTHOR)
Mboyi, Clève D. (AUTHOR)
Cattey, Hélène (AUTHOR)
Roisnel, Thierry (AUTHOR)
Fleurat‐Lessard, Paul (AUTHOR)
Hissler, Muriel (AUTHOR)
Hierso, Jean‐Cyrille (AUTHOR)
Bouit, Pierre‐Antoine (AUTHOR)
Roger, Julien (AUTHOR)
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Źródło:
Angewandte Chemie. 3/20/2023, Vol. 135 Issue 13, p1-6. 6p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Synthesis of Substituted Pyrimido[1,2‐b]indazoles through (3+2+1) Cyclization of 3‐Aminoindazoles, Ketones, and N,N‐Dimethylaminoethanol as One‐Carbon Synthon.
Autorzy:
Qin, Zemin (AUTHOR)
Ma, Renchao (AUTHOR)
Ying, Shenpeng (AUTHOR)
Li, Fanzhu (AUTHOR)
Ma, Yongmin (AUTHOR)
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Źródło:
Advanced Synthesis & Catalysis. 9/20/2022, Vol. 364 Issue 18, p3263-3272. 10p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Synthesis of 2H‐benzo[g]furo/thieno/pyrrolo[2,3‐e]indazoles via Intramolecular Dehydrogenation Photocyclization.
Autorzy:
Zhang, Wei Please confirm that given names (blue) and surnames/family names (vermilion) have been identified correctly. --> (AUTHOR)
Wang, Ping (AUTHOR)
Zhang, Xi (AUTHOR)
Wang, Rui (AUTHOR)
Wang, Tao (AUTHOR)
Liu, Zhicun (AUTHOR)
Zhang, Zunting (AUTHOR)
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Źródło:
Chinese Journal of Chemistry. Aug2021, Vol. 39 Issue 8, p2213-2219. 7p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Design strategies, SAR, and mechanistic insight of Aurora kinase inhibitors in cancer.
Autorzy:
Sankhe K; Department of Pharmaceutical Chemistry, SVKM's Dr. Bhanuben Nanavati College of Pharmacy, Mumbai, India.
Prabhu A; Department of Pharmaceutical Chemistry and Quality Assurance, Bhanuben Nanavati College of Pharmacy, Mumbai, India.
Khan T; Department of Pharmaceutical Chemistry and Quality Assurance, Bhanuben Nanavati College of Pharmacy, Mumbai, India.
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Źródło:
Chemical biology & drug design [Chem Biol Drug Des] 2021 Jul; Vol. 98 (1), pp. 73-93. Date of Electronic Publication: 2021 May 15.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Antineoplastic Agents/*chemistry
Aurora Kinase A/*antagonists & inhibitors
Neoplasms/*drug therapy
Protein Kinase Inhibitors/*chemistry
Animals ; Antineoplastic Agents/pharmacology ; Azepines/chemistry ; Azepines/pharmacology ; Benzamides/chemistry ; Benzamides/pharmacology ; Drug Approval ; Drug Resistance ; Drug Screening Assays, Antitumor ; Flavones/chemistry ; Flavones/pharmacology ; Gene Expression Regulation ; Humans ; Indazoles/chemistry ; Indazoles/pharmacology ; Organophosphates/chemistry ; Organophosphates/pharmacology ; Protein Binding ; Protein Conformation ; Protein Kinase Inhibitors/pharmacology ; Pyrazoles/chemistry ; Pyrazoles/pharmacology ; Pyrimidines/chemistry ; Pyrimidines/pharmacology ; Quinazolines/chemistry ; Quinazolines/pharmacology ; Structure-Activity Relationship
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Identification of 3D motifs based on sequences and structures for binding to CFI-400945, and deep screening-based design of new lead molecules for PLK-4.
Autorzy:
Abdullah M; School of Chemistry, University of Hyderabad, Hyderabad, India.
Guruprasad L; School of Chemistry, University of Hyderabad, Hyderabad, India.
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Źródło:
Chemical biology & drug design [Chem Biol Drug Des] 2021 Oct; Vol. 98 (4), pp. 522-538. Date of Electronic Publication: 2021 Jul 10.
Typ publikacji:
Journal Article
MeSH Terms:
Indazoles/*chemistry
Indoles/*chemistry
Protein Kinase Inhibitors/*chemistry
Protein Serine-Threonine Kinases/*chemistry
Small Molecule Libraries/*chemistry
Amino Acid Sequence ; Catalytic Domain ; Cell Cycle ; Cytokinesis ; Deep Learning ; Humans ; Models, Molecular ; Protein Binding ; Protein Conformation ; Structure-Activity Relationship
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Orthogonal Regulation of Nucleophilic and Electrophilic Sites in Pd‐Catalyzed Regiodivergent Couplings between Indazoles and Isoprene.
Autorzy:
Jiang, Wen‐Shuang (AUTHOR)
Ji, Ding‐Wei (AUTHOR)
Zhang, Wei‐Song (AUTHOR)
Zhang, Gong (AUTHOR)
Min, Xiang‐Ting (AUTHOR)
Hu, Yan‐Cheng (AUTHOR)
Jiang, Xu‐Liang (AUTHOR)
Chen, Qing‐An (AUTHOR)
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Źródło:
Angewandte Chemie. 4/6/2021, Vol. 133 Issue 15, p8402-8409. 8p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Sex-dependent pharmacological profiles of the synthetic cannabinoid MMB-Fubinaca.
Autorzy:
Oliveira da Cruz JF; INSERM, U1215 NeuroCentre Magendie, Bordeaux, France.; University of Bordeaux, Bordeaux, France.; Center for Neural Science, New York University, New York, New York, USA.
Ioannidou C; INSERM, U1215 NeuroCentre Magendie, Bordeaux, France.; University of Bordeaux, Bordeaux, France.
Pagano Zottola AC; INSERM, U1215 NeuroCentre Magendie, Bordeaux, France.; University of Bordeaux, Bordeaux, France.
Muguruza C; Department of Pharmacology, University of the Basque Country, UPV/EHU, Leioa, Spain.; Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Spain.
Gomez-Sotres P; INSERM, U1215 NeuroCentre Magendie, Bordeaux, France.; University of Bordeaux, Bordeaux, France.
Fernandez M; INSERM, U1215 NeuroCentre Magendie, Bordeaux, France.; University of Bordeaux, Bordeaux, France.
Callado LF; Department of Pharmacology, University of the Basque Country, UPV/EHU, Leioa, Spain.; Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Spain.
Marsicano G; INSERM, U1215 NeuroCentre Magendie, Bordeaux, France.; University of Bordeaux, Bordeaux, France.
Busquets-Garcia A; INSERM, U1215 NeuroCentre Magendie, Bordeaux, France.; University of Bordeaux, Bordeaux, France.; Integrative Pharmacology and Systems Neuroscience Research Group, Neurosciences Research Program, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.
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Źródło:
Addiction biology [Addict Biol] 2021 May; Vol. 26 (3), pp. e12940. Date of Electronic Publication: 2020 Aug 03.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Brain/*metabolism
Cannabinoids/*pharmacology
Indazoles/*pharmacology
Valine/*analogs & derivatives
Animals ; Brain/pathology ; Female ; HEK293 Cells ; Humans ; MAP Kinase Signaling System/drug effects ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Middle Aged ; Receptor, Cannabinoid, CB1/metabolism ; Receptor, Cannabinoid, CB2/metabolism ; Sex Factors ; Valine/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Scrotal erythema and geographic tongue subsequent to multikinase inhibiting therapy with Pazopanib.
Autorzy:
Gerber F; Department of Dermatology, University Hospital Basel, Basel, Switzerland.; University of Basel, Basel, Switzerland.
Jungo P; Department of Dermatology, University Hospital Basel, Basel, Switzerland.
Navarini AA; Department of Dermatology, University Hospital Basel, Basel, Switzerland.
Vasconcelos-Berg R; Department of Dermatology, University Hospital Basel, Basel, Switzerland.
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Źródło:
Dermatologic therapy [Dermatol Ther] 2021 Jan; Vol. 34 (1), pp. e14629. Date of Electronic Publication: 2020 Dec 13.
Typ publikacji:
Letter
MeSH Terms:
Glossitis, Benign Migratory*
Erythema/chemically induced ; Humans ; Indazoles ; Pyrimidines ; Sulfonamides/adverse effects
Opinia redakcyjna
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Successful long-term treatment with pazopanib after prior interleukin-2 therapy in patients with metastatic cutaneous angiosarcoma of the scalp.
Autorzy:
Watanabe M; Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Japan.
Nakai K; Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Japan.
Iwaki Y; Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Japan.
Ozawa T; Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Japan.
Kamo R; Division of Dermatology, Kashibaseiki Hospital, Kashiba, Japan.
Tsuruta D; Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Japan.
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Źródło:
Dermatologic therapy [Dermatol Ther] 2020 Nov; Vol. 33 (6), pp. e14007. Date of Electronic Publication: 2020 Jul 26.
Typ publikacji:
Letter
MeSH Terms:
Hemangiosarcoma*/drug therapy
Skin Neoplasms*/drug therapy
Humans ; Indazoles ; Interleukin-2 ; Pyrimidines ; Scalp ; Sulfonamides
Opinia redakcyjna
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Hidradenitis suppurativa associated with pazopanib.
Autorzy:
Cengiz FP; Department of Dermatoveneorology, Bezmialem Vakif University, Istanbul, Turkey.
Kelahmetoglu O; Department of Plastic Surgery, Bezmialem Vakif University, Istanbul, Turkey.
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Źródło:
Dermatologic therapy [Dermatol Ther] 2020 May; Vol. 33 (3), pp. e13315. Date of Electronic Publication: 2020 Apr 06.
Typ publikacji:
Letter
MeSH Terms:
Hidradenitis Suppurativa*/diagnosis
Hidradenitis Suppurativa*/drug therapy
Humans ; Indazoles ; Pyrimidines/adverse effects ; Sulfonamides/adverse effects
Opinia redakcyjna
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Design, synthesis and biological evaluation of pazopanib derivatives as antitumor agents.
Autorzy:
Jia Y; Shandong Institute of Pharmaceutical Industry, Ji'nan, Shandong, 250101, China.
Zhang J
Feng J
Xu F
Pan H
Xu W
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Źródło:
Chemical biology & drug design [Chem Biol Drug Des] 2014 Mar; Vol. 83 (3), pp. 306-16. Date of Electronic Publication: 2014 Feb 01.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Drug Design*
Antineoplastic Agents/*chemical synthesis
Indazoles/*chemical synthesis
Indazoles/*pharmacology
Protein Kinase Inhibitors/*chemical synthesis
Pyrimidines/*chemistry
Sulfonamides/*chemical synthesis
Sulfonamides/*chemistry
Sulfonamides/*pharmacology
Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Aorta/cytology ; Aorta/drug effects ; Aorta/metabolism ; Cell Survival/drug effects ; Cells, Cultured ; Enzyme Activation/drug effects ; Indazoles/chemistry ; Male ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/pharmacology ; Proto-Oncogene Proteins c-abl/antagonists & inhibitors ; Proto-Oncogene Proteins c-abl/metabolism ; Pyrimidines/chemical synthesis ; Pyrimidines/pharmacology ; Rats ; Rats, Sprague-Dawley ; Structure-Activity Relationship ; Vascular Endothelial Growth Factor Receptor-2/antagonists & inhibitors ; Vascular Endothelial Growth Factor Receptor-2/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Eyelashes depigmentation following treatment with pazopanib for metastatic renal cell carcinoma.
Autorzy:
Vaccaro M; Department of Clinical and Experimental Medicine-Dermatology, University of Messina, Italy.
Riso G; Department of Clinical and Experimental Medicine-Dermatology, University of Messina, Italy.
Altavilla D; Department of Biomedical, Dental Sciences and Morphological and Functional Images, University of Messina, Italy.
Cannavò SP; Department of Clinical and Experimental Medicine-Dermatology, University of Messina, Italy.
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Źródło:
Dermatologic therapy [Dermatol Ther] 2019 Nov; Vol. 32 (6), pp. e13140. Date of Electronic Publication: 2019 Nov 14.
Typ publikacji:
Case Reports; Letter
MeSH Terms:
Eyelashes/*drug effects
Pigmentation Disorders/*chemically induced
Protein Kinase Inhibitors/*adverse effects
Pyrimidines/*adverse effects
Sulfonamides/*adverse effects
Carcinoma, Renal Cell/drug therapy ; Carcinoma, Renal Cell/pathology ; Eyelashes/pathology ; Female ; Humans ; Indazoles ; Kidney Neoplasms/drug therapy ; Kidney Neoplasms/pathology ; Middle Aged ; Protein Kinase Inhibitors/administration & dosage ; Pyrimidines/administration & dosage ; Sulfonamides/administration & dosage
Raport
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Functional effects of synthetic cannabinoids versus Δ -THC in mice on body temperature, nociceptive threshold, anxiety, cognition, locomotor/exploratory parameters and depression.
Autorzy:
Schreiber S; Department of Psychiatry, Tel Aviv Sourasky Medical Center, Tel Aviv University Sackler Faculty of Medicine, Israel.; Sagol School of Neuroscience, Tel-Aviv University, Israel.
Bader M; Department of Anatomy and Anthropology, Tel-Aviv University Sackler Faculty of Medicine, Israel.
Lenchinski T; Sagol School of Neuroscience, Tel-Aviv University, Israel.; Department of Anatomy and Anthropology, Tel-Aviv University Sackler Faculty of Medicine, Israel.
Meningher I; Sagol School of Neuroscience, Tel-Aviv University, Israel.
Rubovitch V; Department of Anatomy and Anthropology, Tel-Aviv University Sackler Faculty of Medicine, Israel.
Katz Y; Analytical Laboratory, Division of Identification and Forensic Science, Israel.
Cohen E; Analytical Laboratory, Division of Identification and Forensic Science, Israel.
Gabet Y; Sagol School of Neuroscience, Tel-Aviv University, Israel.; Department of Anatomy and Anthropology, Tel-Aviv University Sackler Faculty of Medicine, Israel.
Rotenberg M; Laboratory of Clinical Toxicology and Pharmacology, Sheba Medical Center, Israel.
Wolf EU; Analytical Laboratory, Division of Identification and Forensic Science, Israel.
Pick CG; Sagol School of Neuroscience, Tel-Aviv University, Israel.; Department of Anatomy and Anthropology, Tel-Aviv University Sackler Faculty of Medicine, Israel.; The Dr. Miriam and Sheldon G. Adelson Chair and Center for the Biology of Addictive Diseases, Tel-Aviv University, Israel.
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Źródło:
Addiction biology [Addict Biol] 2019 May; Vol. 24 (3), pp. 414-425. Date of Electronic Publication: 2018 Feb 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Dronabinol/*pharmacology
Indazoles/*pharmacology
Psychotropic Drugs/*pharmacology
Valine/*analogs & derivatives
Animals ; Anxiety/physiopathology ; Body Temperature/drug effects ; Depression/physiopathology ; Male ; Maze Learning/drug effects ; Memory/drug effects ; Mice, Inbred ICR ; Motor Activity/drug effects ; Nociception/drug effects ; Sensory Thresholds/drug effects ; Valine/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 203

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