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Tytuł :
Design, synthesis and biological evaluation of exiguamine A analogues as IDO1 inhibitors.
Autorzy :
Dong J; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100050, PR China.
Pan X; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100050, PR China.
Yang Y; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100050, PR China.
Zhang G; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100050, PR China.
Xiao Z; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100050, PR China.
Liu Z; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100050, PR China. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Nov 05; Vol. 223, pp. 113631. Date of Electronic Publication: 2021 Jun 12.
Typ publikacji :
Journal Article
MeSH Terms :
Enzyme Inhibitors/*pharmacology
Indoleamine-Pyrrole 2,3,-Dioxygenase/*antagonists & inhibitors
Indoles/*pharmacology
Spiro Compounds/*pharmacology
Cell Line, Tumor ; Cell Survival/drug effects ; Drug Design ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/metabolism ; Enzyme Inhibitors/toxicity ; Humans ; Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism ; Indoles/chemical synthesis ; Indoles/metabolism ; Indoles/toxicity ; Molecular Docking Simulation ; Molecular Structure ; Protein Binding ; Spiro Compounds/chemical synthesis ; Spiro Compounds/metabolism ; Spiro Compounds/toxicity ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Anticancer properties of indole derivatives as IsoCombretastatin A-4 analogues.
Autorzy :
Pecnard S; Université Paris-Saclay, CNRS, BioCIS, 92290, Châtenay-Malabry, France.
Hamze A; Université Paris-Saclay, CNRS, BioCIS, 92290, Châtenay-Malabry, France. Electronic address: .
Bignon J; Institut de Chimie des Substances Naturelles, UPR 2301, CNRS Avenue de La Terrasse, F-91198, Gif sur Yvette, France.
Prost B; Service D'Analyse des Médicaments et Métabolites, IPSIT, Univ. Paris-Sud, UMS 3679 CNRS, US 31 INSERM, Université Paris-Saclay, 92290, Châtenay Malabry, France.
Deroussent A; Metabolic and Systemic Aspects of Oncogenesis (METSY), UMR 9018, CNRS, Institut Gustave Roussy, Université Paris-Saclay, 94805, Villejuif, France.
Gallego-Yerga L; Laboratorio de Química Orgánica y Farmacéutica, Departamento de Ciencias Farmacéuticas, Facultad de Farmacia, Universidad de Salamanca, Salamanca, Spain.
Peláez R; Laboratorio de Química Orgánica y Farmacéutica, Departamento de Ciencias Farmacéuticas, Facultad de Farmacia, Universidad de Salamanca, Salamanca, Spain.
Paik JY; Department of Pharmacy, College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08626, South Korea.
Diederich M; Department of Pharmacy, College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08626, South Korea.
Alami M; Université Paris-Saclay, CNRS, BioCIS, 92290, Châtenay-Malabry, France. Electronic address: .
Provot O; Université Paris-Saclay, CNRS, BioCIS, 92290, Châtenay-Malabry, France. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Nov 05; Vol. 223, pp. 113656. Date of Electronic Publication: 2021 Jun 18.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Indoles/*chemistry
Stilbenes/*chemistry
Tubulin Modulators/*chemistry
Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/metabolism ; Binding Sites ; Cell Cycle Checkpoints/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Drug Resistance, Neoplasm/drug effects ; Drug Screening Assays, Antitumor ; Drug Stability ; Humans ; Indoles/metabolism ; Indoles/pharmacology ; Microsomes, Liver/metabolism ; Molecular Docking Simulation ; Rats ; Stilbenes/metabolism ; Stilbenes/pharmacology ; Structure-Activity Relationship ; Tubulin/chemistry ; Tubulin/metabolism ; Tubulin Modulators/metabolism ; Tubulin Modulators/pharmacology
Czasopismo naukowe
Tytuł :
Design and synthesis of the first indole-based blockers of Panx-1 channel.
Autorzy :
Crocetti L; Neurofarba, Pharmaceutical and Nutraceutical Section, University of Florence, Via Ugo Schiff 6, 50019, Sesto Fiorentino, Italy. Electronic address: .
Guerrini G; Neurofarba, Pharmaceutical and Nutraceutical Section, University of Florence, Via Ugo Schiff 6, 50019, Sesto Fiorentino, Italy. Electronic address: .
Puglioli S; Neurofarba, Pharmaceutical and Nutraceutical Section, University of Florence, Via Ugo Schiff 6, 50019, Sesto Fiorentino, Italy. Electronic address: .
Giovannoni MP; Neurofarba, Pharmaceutical and Nutraceutical Section, University of Florence, Via Ugo Schiff 6, 50019, Sesto Fiorentino, Italy. Electronic address: .
Di Cesare Mannelli L; Neurofarba, Pharmacology and Toxicology Section, University of Florence, Viale Pieraccini 6, 50139, Florence, Italy. Electronic address: .
Lucarini E; Neurofarba, Pharmacology and Toxicology Section, University of Florence, Viale Pieraccini 6, 50139, Florence, Italy. Electronic address: .
Ghelardini C; Neurofarba, Pharmacology and Toxicology Section, University of Florence, Viale Pieraccini 6, 50139, Florence, Italy. Electronic address: .
Wang J; Department of Physiology and Biophysics, University of Miami School of Medicine, 1600 N.W. 10th Avenue Miami, Florida, 33136, USA. Electronic address: .
Dahl G; Department of Physiology and Biophysics, University of Miami School of Medicine, 1600 N.W. 10th Avenue Miami, Florida, 33136, USA. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Nov 05; Vol. 223, pp. 113650. Date of Electronic Publication: 2021 Jun 19.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Indoles/*chemistry
Nerve Tissue Proteins/*metabolism
Animals ; Binding Sites ; Connexins/antagonists & inhibitors ; Connexins/metabolism ; Disease Models, Animal ; Humans ; Indoles/pharmacology ; Indoles/therapeutic use ; Male ; Membrane Potentials/drug effects ; Mice ; Molecular Docking Simulation ; Nerve Tissue Proteins/antagonists & inhibitors ; Neuralgia/chemically induced ; Neuralgia/drug therapy ; Neuralgia/pathology ; Oocytes/drug effects ; Oocytes/physiology ; Oxaliplatin/pharmacology ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Bioisosteric replacements of the indole moiety for the development of a potent and selective PI3Kδ inhibitor: Design, synthesis and biological evaluation.
Autorzy :
Yang C; Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai, 200433, China.
Xu C; Department of Pathology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Li Z; Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai, 200433, China.
Chen Y; Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai, 200433, China.
Wu T; Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai, 200433, China.
Hong H; Lyrae Therapeutics, L.L.C., Shanghai, 200438, China.
Lu M; Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai, 200433, China.
Jia Y; Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai, 200433, China.
Yang Y; Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai, 200433, China.
Liu X; Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai, 200433, China.
Deng M; Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai, 200433, China.
Chen Z; Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai, 200433, China.
Li Q; Department of Pathology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China. Electronic address: .
Ling Y; Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai, 200433, China; Zhuhai-Fudan Innovation Institute, Zhuhai, Guangdong, 519000, China. Electronic address: .
Zhou Y; Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai, 200433, China. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Nov 05; Vol. 223, pp. 113661. Date of Electronic Publication: 2021 Jun 21.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Class I Phosphatidylinositol 3-Kinases/*antagonists & inhibitors
Indoles/*chemistry
Phosphoinositide-3 Kinase Inhibitors/*chemical synthesis
Animals ; Binding Sites ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Class I Phosphatidylinositol 3-Kinases/metabolism ; G1 Phase Cell Cycle Checkpoints/drug effects ; Half-Life ; Humans ; Indoles/metabolism ; Indoles/pharmacology ; Indoles/therapeutic use ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/pathology ; Mice ; Mice, Nude ; Molecular Docking Simulation ; Phosphoinositide-3 Kinase Inhibitors/metabolism ; Phosphoinositide-3 Kinase Inhibitors/pharmacology ; Phosphoinositide-3 Kinase Inhibitors/therapeutic use ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Rats ; Rats, Sprague-Dawley ; Structure-Activity Relationship ; Transplantation, Heterologous
Czasopismo naukowe
Tytuł :
Research progress of indole compounds with potential antidiabetic activity.
Autorzy :
Zhu Y; School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an, 710061, China.
Zhao J; School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an, 710061, China.
Luo L; School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an, 710061, China.
Gao Y; School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an, 710061, China.
Bao H; Department of Pharmacy, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, 710004, China.
Li P; Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, China.
Zhang H; School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an, 710061, China. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Nov 05; Vol. 223, pp. 113665. Date of Electronic Publication: 2021 Jun 23.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Hypoglycemic Agents/*chemistry
Indoles/*chemistry
Carbolines/chemistry ; Carbolines/metabolism ; Carbolines/therapeutic use ; Diabetes Mellitus/drug therapy ; Humans ; Hypoglycemic Agents/chemical synthesis ; Hypoglycemic Agents/metabolism ; Hypoglycemic Agents/therapeutic use ; Indoles/metabolism ; Indoles/therapeutic use ; PPAR alpha/chemistry ; PPAR alpha/metabolism ; PPAR gamma/chemistry ; PPAR gamma/metabolism ; Terpenes/chemistry ; Terpenes/metabolism ; Terpenes/therapeutic use
Czasopismo naukowe
Tytuł :
Design, synthesis and biological evaluation of indole-based [1,2,4]triazolo[4,3-a] pyridine derivatives as novel microtubule polymerization inhibitors.
Autorzy :
Wu CJ; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, 529020, PR China.
Wu JQ; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, 529020, PR China.
Hu Y; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, 529020, PR China.
Pu S; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, 529020, PR China.
Lin Y; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, 529020, PR China.
Zeng Z; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, 529020, PR China.
Hu J; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, 529020, PR China. Electronic address: .
Chen WH; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, 529020, PR China. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Nov 05; Vol. 223, pp. 113629. Date of Electronic Publication: 2021 Jun 17.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Indoles/*pharmacology
Pyridines/*pharmacology
Triazoles/*pharmacology
Tubulin Modulators/*pharmacology
Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/metabolism ; Apoptosis/drug effects ; Cattle ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Drug Design ; G2 Phase Cell Cycle Checkpoints/drug effects ; Humans ; Indoles/chemical synthesis ; Indoles/metabolism ; Molecular Docking Simulation ; Molecular Structure ; Protein Binding ; Pyridines/chemical synthesis ; Pyridines/metabolism ; Rats ; Structure-Activity Relationship ; Triazoles/chemical synthesis ; Triazoles/metabolism ; Tubulin/metabolism ; Tubulin Modulators/chemical synthesis ; Tubulin Modulators/metabolism
Czasopismo naukowe
Tytuł :
Bisindolylmaleimide IX: A novel anti-SARS-CoV2 agent targeting viral main protease 3CLpro demonstrated by virtual screening pipeline and in-vitro validation assays.
Autorzy :
Gupta Y; Infectious Diseases, Mayo Clinic, Jacksonville, FL, USA.
Maciorowski D; Loyola University Chicago, Chicago, IL, USA.
Zak SE; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA; The Geneva Foundation, 917 Pacific Avenue, Tacoma, WA 98402, USA.
Jones KA; Department of Chemistry, The University of Chicago, 5801 South Ellis Avenue, Chicago, IL, USA.
Kathayat RS; Department of Chemistry, The University of Chicago, 5801 South Ellis Avenue, Chicago, IL, USA.
Azizi SA; Department of Chemistry, The University of Chicago, 5801 South Ellis Avenue, Chicago, IL, USA.
Mathur R; Loyola University Chicago, Chicago, IL, USA.
Pearce CM; Loyola University Chicago, Chicago, IL, USA.
Ilc DJ; Loyola University Chicago, Chicago, IL, USA.
Husein H; Loyola University Chicago, Chicago, IL, USA.
Herbert AS; The Geneva Foundation, 917 Pacific Avenue, Tacoma, WA 98402, USA.
Bharti A; Division of Infectious Diseases, Department of Medicine, University of California, San Diego, CA, 92093, USA.
Rathi B; Laboratory for Translational Chemistry and Drug Discovery, Hansraj College, University of Delhi, India.
Durvasula R; Infectious Diseases, Mayo Clinic, Jacksonville, FL, USA.
Becker DP; Loyola University Chicago, Chicago, IL, USA.
Dickinson BC; Department of Chemistry, The University of Chicago, 5801 South Ellis Avenue, Chicago, IL, USA.
Dye JM; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA; The Geneva Foundation, 917 Pacific Avenue, Tacoma, WA 98402, USA. Electronic address: .
Kempaiah P; Infectious Diseases, Mayo Clinic, Jacksonville, FL, USA. Electronic address: .
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Źródło :
Methods (San Diego, Calif.) [Methods] 2021 Nov; Vol. 195, pp. 57-71. Date of Electronic Publication: 2021 Jan 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiviral Agents/*administration & dosage
Coronavirus 3C Proteases/*antagonists & inhibitors
Drug Delivery Systems/*standards
Indoles/*administration & dosage
Maleimides/*administration & dosage
SARS-CoV-2/*drug effects
SARS-CoV-2/*enzymology
Antiviral Agents/metabolism ; Coronavirus 3C Proteases/chemistry ; Coronavirus 3C Proteases/metabolism ; Dose-Response Relationship, Drug ; Drug Delivery Systems/methods ; Drug Evaluation, Preclinical/methods ; Drug Repositioning/methods ; Drug Repositioning/standards ; High-Throughput Screening Assays/methods ; High-Throughput Screening Assays/standards ; Humans ; Indoles/chemistry ; Indoles/metabolism ; Maleimides/chemistry ; Maleimides/metabolism ; Molecular Docking Simulation/methods ; Molecular Docking Simulation/standards ; Protein Structure, Secondary ; Reproducibility of Results ; SARS-CoV-2/chemistry
Czasopismo naukowe
Tytuł :
Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19.
Autorzy :
Boras B; Worldwide Research and Development, Pfizer Inc, La Jolla, CA, 92121, USA.
Jones RM; Worldwide Research and Development, Pfizer Inc, La Jolla, CA, 92121, USA. .
Anson BJ; Department of Biological Sciences, Purdue University, West Lafayette, IN, 47907, USA.
Arenson D; Worldwide Research and Development, Pfizer Inc, Groton, CT, 06340, USA.
Aschenbrenner L; Worldwide Research and Development, Pfizer Inc, Groton, CT, 06340, USA.
Bakowski MA; Calibr, a division of The Scripps Research Institute, La Jolla, CA, 92037, USA.
Beutler N; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, 92037, USA.
Binder J; Worldwide Research and Development, Pfizer Inc, La Jolla, CA, 92121, USA.
Chen E; Calibr, a division of The Scripps Research Institute, La Jolla, CA, 92037, USA.
Eng H; Worldwide Research and Development, Pfizer Inc, Groton, CT, 06340, USA.
Hammond H; Department of Microbiology and Immunology University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Hammond J; Worldwide Research and Development, Pfizer Inc., Collegeville, PA, 19426, USA.
Haupt RE; Department of Microbiology and Immunology University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Hoffman R; Worldwide Research and Development, Pfizer Inc, La Jolla, CA, 92121, USA.
Kadar EP; Worldwide Research and Development, Pfizer Inc, Groton, CT, 06340, USA.
Kania R; Worldwide Research and Development, Pfizer Inc, La Jolla, CA, 92121, USA.
Kimoto E; Worldwide Research and Development, Pfizer Inc, Groton, CT, 06340, USA.
Kirkpatrick MG; Calibr, a division of The Scripps Research Institute, La Jolla, CA, 92037, USA.
Lanyon L; Worldwide Research and Development, Pfizer Inc, Groton, CT, 06340, USA.
Lendy EK; Department of Biochemistry, Purdue University, West Lafayette, IN, 47907, USA.
Lillis JR; Worldwide Research and Development, Pfizer Inc, Sandwich, CT13 9ND, UK.
Logue J; Department of Microbiology and Immunology University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Luthra SA; Worldwide Research and Development, Pfizer Inc, Cambridge, MA, 02139, USA.
Ma C; Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ, 85721, USA.
Mason SW; Worldwide Research and Development, Pfizer Inc, Groton, CT, 06340, USA.; Worldwide Research and Development, Pfizer Inc., Pearl River, NY, 10965, USA.
McGrath ME; Department of Microbiology and Immunology University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Noell S; Worldwide Research and Development, Pfizer Inc, Groton, CT, 06340, USA.
Obach RS; Worldwide Research and Development, Pfizer Inc, Groton, CT, 06340, USA.
O' Brien MN; Worldwide Research and Development, Pfizer Inc, Lake Forest, IL, 60045, USA.
O'Connor R; Worldwide Research and Development, Pfizer Inc, Groton, CT, 06340, USA.
Ogilvie K; Worldwide Research and Development, Pfizer Inc, Groton, CT, 06340, USA.
Owen D; Worldwide Research and Development, Pfizer Inc, Cambridge, MA, 02139, USA.
Pettersson M; Worldwide Research and Development, Pfizer Inc, Cambridge, MA, 02139, USA.
Reese MR; Worldwide Research and Development, Pfizer Inc, Groton, CT, 06340, USA.
Rogers TF; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, 92037, USA.; UC San Diego Division of Infectious Diseases and Global Public Health, UC San Diego School of Medicine, La Jolla, CA, 92093, USA.
Rosales R; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Rossulek MI; Worldwide Research and Development, Pfizer Inc, Cambridge, MA, 02139, USA.
Sathish JG; Worldwide Research and Development, Pfizer Inc., Pearl River, NY, 10965, USA.
Shirai N; Worldwide Research and Development, Pfizer Inc, Groton, CT, 06340, USA.
Steppan C; Worldwide Research and Development, Pfizer Inc, Groton, CT, 06340, USA.
Ticehurst M; Worldwide Research and Development, Pfizer Inc, Sandwich, CT13 9ND, UK.
Updyke LW; Worldwide Research and Development, Pfizer Inc, Cambridge, MA, 02139, USA.
Weston S; Department of Microbiology and Immunology University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Zhu Y; Worldwide Research and Development, Pfizer Inc., Pearl River, NY, 10965, USA.
White KM; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
García-Sastre A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Wang J; Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ, 85721, USA.
Chatterjee AK; Calibr, a division of The Scripps Research Institute, La Jolla, CA, 92037, USA.
Mesecar AD; Department of Biological Sciences, Purdue University, West Lafayette, IN, 47907, USA.; Department of Biochemistry, Purdue University, West Lafayette, IN, 47907, USA.
Frieman MB; Department of Microbiology and Immunology University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Anderson AS; Worldwide Research and Development, Pfizer Inc., Pearl River, NY, 10965, USA.
Allerton C; Worldwide Research and Development, Pfizer Inc, Cambridge, MA, 02139, USA.
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Źródło :
Nature communications [Nat Commun] 2021 Oct 18; Vol. 12 (1), pp. 6055. Date of Electronic Publication: 2021 Oct 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
COVID-19/*drug therapy
Coronavirus 3C Proteases/*antagonists & inhibitors
Coronavirus Protease Inhibitors/*administration & dosage
Indoles/*administration & dosage
Leucine/*administration & dosage
Pyrrolidinones/*administration & dosage
Adenosine Monophosphate/administration & dosage ; Adenosine Monophosphate/adverse effects ; Adenosine Monophosphate/analogs & derivatives ; Adenosine Monophosphate/pharmacokinetics ; Alanine/administration & dosage ; Alanine/adverse effects ; Alanine/analogs & derivatives ; Alanine/pharmacokinetics ; Animals ; COVID-19/virology ; Chlorocebus aethiops ; Coronavirus 229E, Human/drug effects ; Coronavirus 229E, Human/enzymology ; Coronavirus Protease Inhibitors/adverse effects ; Coronavirus Protease Inhibitors/pharmacokinetics ; Disease Models, Animal ; Drug Design ; Drug Synergism ; Drug Therapy, Combination ; HeLa Cells ; Humans ; Indoles/adverse effects ; Indoles/pharmacokinetics ; Infusions, Intravenous ; Leucine/adverse effects ; Leucine/pharmacokinetics ; Mice ; Pyrrolidinones/adverse effects ; Pyrrolidinones/pharmacokinetics ; SARS Virus/drug effects ; SARS Virus/enzymology ; SARS-CoV-2/drug effects ; SARS-CoV-2/enzymology ; Vero Cells
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Indole Chloropyridinyl Ester-Derived SARS-CoV-2 3CLpro Inhibitors: Enzyme Inhibition, Antiviral Efficacy, Structure-Activity Relationship, and X-ray Structural Studies.
Autorzy :
Ghosh AK; Department of Chemistry and Department of Medicinal Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.
Raghavaiah J; Department of Chemistry and Department of Medicinal Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.
Shahabi D; Department of Chemistry and Department of Medicinal Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.
Yadav M; Department of Chemistry and Department of Medicinal Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.
Anson BJ; Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, United States.
Lendy EK; Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907, United States.
Hattori SI; Department of Refractory Viral Infections, National Center for Global Health and Medicine Research Institute, Shinjuku, Tokyo 162-8655, Japan.
Higashi-Kuwata N; Department of Refractory Viral Infections, National Center for Global Health and Medicine Research Institute, Shinjuku, Tokyo 162-8655, Japan.
Mitsuya H; Department of Hematology and Infectious Diseases, Kumamoto University School of Medicine, Kumamoto 860-8556, Japan.; Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, National Cancer Institute, Bethesda, Maryland 20892, United States.; Department of Refractory Viral Infections, National Center for Global Health and Medicine Research Institute, Shinjuku, Tokyo 162-8655, Japan.
Mesecar AD; Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, United States.; Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907, United States.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Oct 14; Vol. 64 (19), pp. 14702-14714. Date of Electronic Publication: 2021 Sep 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Coronavirus 3C Proteases/*antagonists & inhibitors
Indoles/*chemistry
Protease Inhibitors/*chemistry
SARS-CoV-2/*enzymology
Adenosine Monophosphate/analogs & derivatives ; Adenosine Monophosphate/chemistry ; Adenosine Monophosphate/metabolism ; Alanine/analogs & derivatives ; Alanine/chemistry ; Alanine/metabolism ; Animals ; Binding Sites ; COVID-19/pathology ; COVID-19/virology ; Chlorocebus aethiops ; Coronavirus 3C Proteases/metabolism ; Crystallography, X-Ray ; Humans ; Indoles/chemical synthesis ; Indoles/metabolism ; Molecular Dynamics Simulation ; Protease Inhibitors/chemical synthesis ; Protease Inhibitors/metabolism ; Pyridines/chemistry ; SARS-CoV-2/isolation & purification ; Structure-Activity Relationship ; Vero Cells
Czasopismo naukowe
Tytuł :
Novel photochromic inhibitor for mitotic kinesin Eg5 which forms multiple isomerization states.
Autorzy :
Alrazi IM; Department of Biosciences, Graduate School of Science and Engineering, Soka University, 1-236 Tangi-cho, Hachioji, Tokyo 192-8577, Japan.
Sadakane K; Department of Biosciences, Graduate School of Science and Engineering, Soka University, 1-236 Tangi-cho, Hachioji, Tokyo 192-8577, Japan.
Maruta S; Department of Biosciences, Graduate School of Science and Engineering, Soka University, 1-236 Tangi-cho, Hachioji, Tokyo 192-8577, Japan.
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Źródło :
Journal of biochemistry [J Biochem] 2021 Oct 11; Vol. 170 (2), pp. 229-237.
Typ publikacji :
Journal Article
MeSH Terms :
Mitosis*
Azo Compounds/*pharmacology
Benzopyrans/*pharmacology
Indoles/*pharmacology
Kinesin/*antagonists & inhibitors
Kinesin/*metabolism
Nitro Compounds/*pharmacology
Adenosine Triphosphatases/metabolism ; Azo Compounds/chemistry ; Azo Compounds/metabolism ; Benzopyrans/chemistry ; Benzopyrans/metabolism ; Cell Division/drug effects ; Cell Movement/drug effects ; Humans ; Indoles/chemistry ; Indoles/metabolism ; Isomerism ; Kinesin/chemistry ; Light ; Luminescent Agents/pharmacology ; Microtubules/metabolism ; Nitro Compounds/chemistry ; Nitro Compounds/metabolism ; Protein Binding
Czasopismo naukowe
Tytuł :
Preclinical Studies on the Effect of Rucaparib in Ovarian Cancer: Impact of BRCA2 Status.
Autorzy :
Saravi S; Division of Biosciences, College of Health, Medicine and Life Sciences, Brunel University London, Uxbridge UB8 3PH, UK.
Alizzi Z; Division of Biosciences, College of Health, Medicine and Life Sciences, Brunel University London, Uxbridge UB8 3PH, UK.; Mount Vernon Cancer Centre, Rickmansworth Road, Northwood HA6 2RN, UK.
Tosi S; Division of Biosciences, College of Health, Medicine and Life Sciences, Brunel University London, Uxbridge UB8 3PH, UK.
Hall M; Division of Biosciences, College of Health, Medicine and Life Sciences, Brunel University London, Uxbridge UB8 3PH, UK.; Mount Vernon Cancer Centre, Rickmansworth Road, Northwood HA6 2RN, UK.
Karteris E; Division of Biosciences, College of Health, Medicine and Life Sciences, Brunel University London, Uxbridge UB8 3PH, UK.; Division of Thoracic Surgery, The Royal Brompton & Harefield NHS Foundation Trust, Harefield Hospital, Harefield, Uxbridge UB9 6JH, UK.
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Źródło :
Cells [Cells] 2021 Sep 15; Vol. 10 (9). Date of Electronic Publication: 2021 Sep 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Ovarian Neoplasms*/drug therapy
Ovarian Neoplasms*/genetics
Ovarian Neoplasms*/metabolism
Poly (ADP-Ribose) Polymerase-1*/genetics
Poly (ADP-Ribose) Polymerase-1*/metabolism
BRCA2 Protein/*genetics
Indoles/*pharmacology
Cell Line, Tumor ; DNA Damage/drug effects ; Female ; Humans ; Indoles/adverse effects ; Indoles/therapeutic use ; Mutation ; Poly(ADP-ribose) Polymerase Inhibitors/adverse effects ; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology ; Poly(ADP-ribose) Polymerase Inhibitors/therapeutic use ; Recombinational DNA Repair/genetics ; Signal Transduction/drug effects ; TOR Serine-Threonine Kinases/drug effects ; TOR Serine-Threonine Kinases/metabolism
Czasopismo naukowe
Tytuł :
An Electrochemical Route for Special Oxidative Ring-Opening of Indoles.
Autorzy :
Qin H; College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, 30 Puzhu Rd S., Nanjing, 211816, P. R. China.
Yang Z; School of Engineering, China Pharmaceutical University, No. 639 Longmian Avenue, Nanjing, 211198, P. R. China.
Zhang Z; College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, 30 Puzhu Rd S., Nanjing, 211816, P. R. China.
Liu C; College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, 30 Puzhu Rd S., Nanjing, 211816, P. R. China.
He W; College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, 30 Puzhu Rd S., Nanjing, 211816, P. R. China.
Fang Z; College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, 30 Puzhu Rd S., Nanjing, 211816, P. R. China.; State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, 30 Puzhu Rd S., Nanjing, 211816, P. R. China.
Guo K; College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, 30 Puzhu Rd S., Nanjing, 211816, P. R. China.; State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, 30 Puzhu Rd S., Nanjing, 211816, P. R. China.
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Źródło :
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2021 Sep 09; Vol. 27 (51), pp. 13024-13028. Date of Electronic Publication: 2021 Aug 05.
Typ publikacji :
Journal Article
MeSH Terms :
Indoles*
Metals*
Catalysis ; Oxidation-Reduction ; Oxidative Stress
Czasopismo naukowe
Tytuł :
Investigation of distinct contribution of nitric oxide and each reactive oxygen species in indole-3-propionic-acid-induced apoptosis-like death in Escherichia coli.
Autorzy :
Kwun MS; School of Life Sciences, BK 21 FOUR KNU Creative BioResearch Group, Kyungpook National University, Daegu 41566, Republic of Korea.
Lee DG; School of Life Sciences, BK 21 FOUR KNU Creative BioResearch Group, Kyungpook National University, Daegu 41566, Republic of Korea. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Nov 15; Vol. 285, pp. 120003. Date of Electronic Publication: 2021 Sep 29.
Typ publikacji :
Journal Article
MeSH Terms :
Antibiosis*
Apoptosis*
Escherichia coli/*physiology
Indoles/*metabolism
Microbiota/*physiology
Nitric Oxide/*physiology
Propionates/*metabolism
Reactive Oxygen Species/*metabolism
DNA Fragmentation ; Escherichia coli/drug effects ; Glutathione/metabolism ; Indoles/pharmacology ; Lipid Peroxidation ; Microbiota/drug effects ; Propionates/pharmacology
Czasopismo naukowe
Tytuł :
Post-treatments of polydopamine coatings influence cellular response.
Autorzy :
Davidsen MB; Interdisciplinary Nanoscience Center (iNANO), Faculty of Natural Sciences, Aarhus University, Denmark.
Teixeira JFL; Department of Physiology and Pathology, School of Dentistry, São Paulo State University, Brazil.
Dehli J; Interdisciplinary Nanoscience Center (iNANO), Faculty of Natural Sciences, Aarhus University, Denmark.
Karlsson C; Interdisciplinary Nanoscience Center (iNANO), Faculty of Natural Sciences, Aarhus University, Denmark; Sino-Danish Center for Education and Research, Denmark.
Kraft D; Department of Dentistry and Oral Health, Faculty of Health, Aarhus University, Denmark.
Souza PPC; Innovation in Biomaterials Laboratory (iBioM), School of Dentistry, Federal University of Goiás, Brazil; Department of Physiology and Pathology, School of Dentistry, São Paulo State University, Brazil.
Foss M; Interdisciplinary Nanoscience Center (iNANO), Faculty of Natural Sciences, Aarhus University, Denmark; Sino-Danish Center for Education and Research, Denmark. Electronic address: .
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Źródło :
Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2021 Nov; Vol. 207, pp. 111972. Date of Electronic Publication: 2021 Jul 13.
Typ publikacji :
Journal Article
MeSH Terms :
Biocompatible Materials*
Indoles*/pharmacology
Animals ; Cell Adhesion ; Humans ; Keratinocytes ; Mice ; Polymers
Czasopismo naukowe
Tytuł :
Site-selective C-H functionalization to access the arene backbone of indoles and quinolines.
Autorzy :
Prabagar B; State Key Laboratory of Coordination Chemistry, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China. .
Yang Y; State Key Laboratory of Coordination Chemistry, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China. .
Shi Z; State Key Laboratory of Coordination Chemistry, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China. .
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Źródło :
Chemical Society reviews [Chem Soc Rev] 2021 Oct 18; Vol. 50 (20), pp. 11249-11269. Date of Electronic Publication: 2021 Oct 18.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Indoles*
Quinolines*
Catalysis
Czasopismo naukowe
Tytuł :
Nintedanib in idiopathic and secondary pleuroparenchymal fibroelastosis.
Autorzy :
Nasser M; Department of Respiratory Medicine, National Coordinating Reference Center for Rare Pulmonary Diseases, Louis Pradel Hospital, Hospices Civils de Lyon, 28 avenue Doyen Lepine, 69677, Lyon, France.
Si-Mohamed S; Radiology Department, Hospices Civils de Lyon, Lyon, France.; CREATIS, CNRS UMR 5220, INSERM U1206, INSA-Lyon, University Claude Bernard Lyon1, Lyon, France.
Turquier S; Department of Respiratory Physiology, Hospices Civils de Lyon, Louis Pradel Hospital, Lyon, France.
Traclet J; Department of Respiratory Medicine, National Coordinating Reference Center for Rare Pulmonary Diseases, Louis Pradel Hospital, Hospices Civils de Lyon, 28 avenue Doyen Lepine, 69677, Lyon, France.
Ahmad K; Department of Respiratory Medicine, National Coordinating Reference Center for Rare Pulmonary Diseases, Louis Pradel Hospital, Hospices Civils de Lyon, 28 avenue Doyen Lepine, 69677, Lyon, France.
Philit F; Department of Respiratory Medicine, Croix Rousse Hospital, Hospices Civil de Lyon, Lyon, France.
Bonniaud P; Department of Pulmonary Medicine and Intensive Care Unit, Constitutive Reference Center for Rare Pulmonary Diseases, François Mitterrand Teaching Hospital, Inserm U1231, University Bourgogne-Franche Comté, Dijon, France.
Chalabreysse L; Department of Pathology, Louis Pradel Hospital, Hospices Civils de Lyon, Lyon, France.; UMR754, INRAE, Université Claude Bernard Lyon 1, Université de Lyon, Lyon, France.
Thivolet-Béjui F; Department of Pathology, Louis Pradel Hospital, Hospices Civils de Lyon, Lyon, France.; UMR754, INRAE, Université Claude Bernard Lyon 1, Université de Lyon, Lyon, France.
Cottin V; Department of Respiratory Medicine, National Coordinating Reference Center for Rare Pulmonary Diseases, Louis Pradel Hospital, Hospices Civils de Lyon, 28 avenue Doyen Lepine, 69677, Lyon, France. .; UMR754, INRAE, Université Claude Bernard Lyon 1, Université de Lyon, Lyon, France. .
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Źródło :
Orphanet journal of rare diseases [Orphanet J Rare Dis] 2021 Oct 09; Vol. 16 (1), pp. 419. Date of Electronic Publication: 2021 Oct 09.
Typ publikacji :
Journal Article
MeSH Terms :
Indoles*/therapeutic use
Humans ; Prospective Studies ; Respiratory Function Tests ; Retrospective Studies
Czasopismo naukowe
Tytuł :
Patents on Violacein: A Compound with Great Diversity of Biological Activities and Industrial Potential.
Autorzy :
Durán N; Laboratory of Urogenital Carcinogenesis and Immunotherapy, Biology Institute, Department of Structural and Functional Biology, University of Campinas, Campinas, Sao Paulo, Brazil.
Fávaro WJ; Laboratory of Urogenital Carcinogenesis and Immunotherapy, Biology Institute, Department of Structural and Functional Biology, University of Campinas, Campinas, Sao Paulo, Brazil.
Brocchi M; Laboratory of Tropical Diseases, Institute of Biology, Department of Genetic, Evolution, Microbiology and Immunology. University of Campinas, Campinas, Sao Paulo, Brazil.
Justo GZ; Department of Pharmaceutical Sciences and Department of Biochemistry, Federal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil.
Castro GR; Nanobiomaterials Laboratory, Institute of Applied Biotechnology CINDEFI (UNLP-CONICET, CCT La Plata), Department of Chemistry, School of Sciences, Universidad Nacional de La Plata, La Plata, Argentina.
Durán M; Laboratory of Urogenital Carcinogenesis and Immunotherapy, Biology Institute, Department of Structural and Functional Biology, University of Campinas, Campinas, Sao Paulo, Brazil.
Nakazato G; Laboratory of Basic and Applied Bacteriology, Department of Microbiology, Biology Sciences Center, Londrina State University (UEL), Londrina, Brazil.
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Źródło :
Recent patents on biotechnology [Recent Pat Biotechnol] 2021 Oct 04; Vol. 15 (2), pp. 102-111.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Indoles*
Patents as Topic*
Biotechnology
Czasopismo naukowe
Tytuł :
The Natural Pigment Violacein Potentially Suppresses the Proliferation and Stemness of Hepatocellular Carcinoma Cells In Vitro.
Autorzy :
Kim YJ; Department of Life Science and Biochemical Engineering, Sun Moon University, Asan 31460, Korea.
Yuk N; Department of Pharmaceutical Engineering and Biotechnology, Sun Moon University, Asan 31460, Korea.
Shin HJ; Department of Life Science and Biochemical Engineering, Sun Moon University, Asan 31460, Korea.
Jung HJ; Department of Life Science and Biochemical Engineering, Sun Moon University, Asan 31460, Korea.; Department of Pharmaceutical Engineering and Biotechnology, Sun Moon University, Asan 31460, Korea.; Genome-Based BioIT Convergence Institute, Sun Moon University, Asan 31460, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Oct 03; Vol. 22 (19). Date of Electronic Publication: 2021 Oct 03.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Biological Products/*pharmacology
Cell Self Renewal/*drug effects
Indoles/*pharmacology
Neoplastic Stem Cells/*drug effects
Neoplastic Stem Cells/*metabolism
Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; Biological Products/chemistry ; Carcinoma, Hepatocellular ; Cell Cycle Checkpoints/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Humans ; Indoles/chemistry ; Liver Neoplasms ; MAP Kinase Signaling System/drug effects ; Proto-Oncogene Proteins c-akt/metabolism ; STAT3 Transcription Factor/metabolism
Czasopismo naukowe
Tytuł :
Spatially-resolved pharmacokinetic/pharmacodynamic modelling of bystander effects of a nitrochloromethylbenzindoline hypoxia-activated prodrug.
Autorzy :
Hong CR; Auckland Cancer Society Research Centre, University of Auckland, 85 Park Rd, Grafton, Auckland, 1023, New Zealand.
Mehta SY; Department of Pathology, Otago University, Dunedin, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand.
Liyanage HDS; Auckland Cancer Society Research Centre, University of Auckland, 85 Park Rd, Grafton, Auckland, 1023, New Zealand.
McManaway SP; Auckland Cancer Society Research Centre, University of Auckland, 85 Park Rd, Grafton, Auckland, 1023, New Zealand.
Lee HH; Auckland Cancer Society Research Centre, University of Auckland, 85 Park Rd, Grafton, Auckland, 1023, New Zealand.
Jaiswal JK; Auckland Cancer Society Research Centre, University of Auckland, 85 Park Rd, Grafton, Auckland, 1023, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand.
Bogle G; Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand.
Tercel M; Auckland Cancer Society Research Centre, University of Auckland, 85 Park Rd, Grafton, Auckland, 1023, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand.
Pruijn FB; Auckland Cancer Society Research Centre, University of Auckland, 85 Park Rd, Grafton, Auckland, 1023, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand.
Wilson WR; Auckland Cancer Society Research Centre, University of Auckland, 85 Park Rd, Grafton, Auckland, 1023, New Zealand. .; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand. .
Hicks KO; Auckland Cancer Society Research Centre, University of Auckland, 85 Park Rd, Grafton, Auckland, 1023, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand.
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Źródło :
Cancer chemotherapy and pharmacology [Cancer Chemother Pharmacol] 2021 Oct; Vol. 88 (4), pp. 673-687. Date of Electronic Publication: 2021 Jul 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Hypoxia*
Models, Biological*
Bystander Effect/*drug effects
Indoles/*pharmacology
Chromatography, Liquid ; Coculture Techniques ; Escherichia coli Proteins/genetics ; HCT116 Cells ; Humans ; Indoles/pharmacokinetics ; NADPH-Ferrihemoprotein Reductase/genetics ; Nitroreductases/genetics ; Prodrugs ; Spheroids, Cellular/cytology ; Tandem Mass Spectrometry
Czasopismo naukowe
Tytuł :
Bowl-like mesoporous polydopamine with size exclusion for highly selective recognition of endogenous glycopeptides.
Autorzy :
Yan Y; Zhejiang Provincial Key Laboratory of Advanced Mass Spectrometry and Molecular Analysis, PR China; Institute of Mass Spectrometry, School of Materials Science & Chemical Engineering, Ningbo University, Ningbo, 315211, PR China.
Han R; Zhejiang Provincial Key Laboratory of Advanced Mass Spectrometry and Molecular Analysis, PR China; Institute of Mass Spectrometry, School of Materials Science & Chemical Engineering, Ningbo University, Ningbo, 315211, PR China. Electronic address: .
Hou Y; Department of Microelectronic Science and Engineering, Ningbo University, Ningbo, 315211, PR China.
Zhang H; Zhejiang Provincial Key Laboratory of Advanced Mass Spectrometry and Molecular Analysis, PR China; Institute of Mass Spectrometry, School of Materials Science & Chemical Engineering, Ningbo University, Ningbo, 315211, PR China.
Yu J; Faculty of Electrical Engineering and Computer Science, Ningbo University, Ningbo, 315211, PR China.
Gao W; Zhejiang Provincial Key Laboratory of Advanced Mass Spectrometry and Molecular Analysis, PR China; Institute of Mass Spectrometry, School of Materials Science & Chemical Engineering, Ningbo University, Ningbo, 315211, PR China.
Xu L; Zhejiang Provincial Key Laboratory of Advanced Mass Spectrometry and Molecular Analysis, PR China; Institute of Mass Spectrometry, School of Materials Science & Chemical Engineering, Ningbo University, Ningbo, 315211, PR China.
Tang K; Zhejiang Provincial Key Laboratory of Advanced Mass Spectrometry and Molecular Analysis, PR China; Institute of Mass Spectrometry, School of Materials Science & Chemical Engineering, Ningbo University, Ningbo, 315211, PR China. Electronic address: .
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Źródło :
Talanta [Talanta] 2021 Oct 01; Vol. 233, pp. 122468. Date of Electronic Publication: 2021 May 11.
Typ publikacji :
Journal Article
MeSH Terms :
Glycopeptides*
Indoles*
Horseradish Peroxidase ; Humans ; Hydrophobic and Hydrophilic Interactions ; Polymers
Czasopismo naukowe

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